Drug & supplement interaction

Adenosine + Aspirin, Dipyridamole

Aspirin, Dipyridamole brand names: Aggrenox, Asasantin Retard.

Major Interaction
Medically reviewed by · Updated September 2026
The bottom line Major

Adenosine has a major interaction with Aspirin, Dipyridamole. Dipyridamole can increase the therapeutic and toxic effects of adenosine.

Read the full interaction report
SeverityMajor
LikelihoodLikely
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Adenosine and Aspirin, Dipyridamole

Here is the interaction we found between these two, with the evidence behind it.

Major

DIPYRIDAMOLE (Persantine)

Dipyridamole can increase the therapeutic and toxic effects of adenosine.
Dipyridamole decreases the metabolism of adenosine. Intravenous infusion of adenosine in patients who are taking dipyridamole can cause dizziness, bradycardia, and syncope. Dipyridamole should be discontinued for several days prior to a cardiac stress test using adenosine.
Severity Major Likelihood Likely Evidence D

Well-controlled human studies have demonstrated the likely existence of this interaction.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the key thing with Aggrenox: one of its ingredients, dipyridamole, slows down how fast your body clears adenosine. So if you add an adenosine supplement on top, the adenosine can hang around longer and hit harder than expected. That can mean dizziness, a slow heartbeat, lightheadedness, or even fainting. This is a well-recognized issue, which is exactly why doctors have you stop dipyridamole for a few days before an adenosine stress test.

Honestly, the bigger concern here is the prescription IV form of adenosine. Over-the-counter adenosine (AMP/ATP) pills are poorly absorbed and weakly studied, so they may not do much either way. Still, given the heart-rhythm risk, I'd run any adenosine product past your pharmacist or doctor before combining it with Aggrenox.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Litmann L, Anderson JD, Monroe MH. Adenosine and Aggrenox: A hazardous combination. Ann Intern Med 2002;137:E-76. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Adenosine Also Interacts With Other Medications

Adenosine has 1 major, 1 moderate, 44 minor known drug interactions in our database — the Aspirin, Dipyridamole one above is one of them. If you take anything else, check it against the full list below.

Major 1 Moderate 1 Minor 44 No known interaction 2,784 (incl. Aspirin, Dipyridamole)
Taking anything else?

Check Another of Your Medications Against Adenosine

Covers the 2,830 medications we’ve checked against Adenosine. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Aspirin, Dipyridamole

This page covers Adenosine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Aspirin, Dipyridamole page lists 243 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Danshen (major) and Piracetam (major).

By severity: 8 major · 206 moderate · 29 minor.

From our pharmacist’s overview on the Aspirin, Dipyridamole page

“Aspirin with dipyridamole (Aggrenox) keeps platelets from clumping to prevent a second stroke, so it should be no surprise that the great bulk of this page is about bleeding. Most listed supplements can thin the blood further, and the risk reaches into ordinary life: beer and wine both carry major ratings because alcohol alongside aspi…”

Reviewed by 2 · Jul 18, 2026

Open the Aspirin, Dipyridamole interaction page

One more smart check

Taking Adenosine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 66 real supplement products containing Adenosine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Adenosine. Your product may carry other ingredients that interact with Aspirin, Dipyridamole too, on top of Adenosine — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Adenosine and Aspirin, Dipyridamole Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Adenosine
Top 25%

#301 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Aspirin, Dipyridamole
Steady interest

#1,738 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Adenosine

What is Adenosine?

Adenosine
  • Energy and cellular function support
  • Athletic performance and muscle energy
  • Circulation support
  • General wellness

Adenosine is a natural building block your body uses for energy and cell signaling, and a prescription injectable version is used by doctors to treat certain fast heart rhythms. As an over-the-counter supplement (often sold as AMP or ATP), there is little strong evidence that swallowing it boosts energy or performance, and quality can vary. Talk to your pharmacist before using adenosine supplements, especially if you have a heart condition.

Read the full Adenosine monograph & all interactions
Keep checking

Other Drugs & Adenosine

Browse every other medication we’ve checked against Adenosine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

1Major
1Moderate
44Minor
2,783No known interaction
1 Major 1 Moderate 44 Minor 2,783 No interaction
Major

1 interaction

Moderate

1 interaction

Minor

44 interactions

No interaction 2,783 drugs checked — show the list

We also checked Adenosine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,783 medications checked with no known interaction — see the full Adenosine list.

See the full Adenosine interactions page
See every supplement checked against Aspirin, Dipyridamole, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Adenosine monograph › Uses, safety, and every drug interaction in one place Aspirin, Dipyridamole supplement interactions › Every supplement checked against Aspirin, Dipyridamole, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Adenosine and Aspirin, Dipyridamole Together: Common Questions

Can you take Adenosine with Aspirin, Dipyridamole?
This is rated a major interaction, so the combination is best avoided unless your doctor or pharmacist has specifically told you otherwise. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Adenosine and Aspirin, Dipyridamole interaction?
We rate it Major. This is a clinically significant combination that is generally best avoided, or used only under the direct supervision of your physician or pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Aspirin, Dipyridamole and Adenosine?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.