Medication interaction hub

What Supplements Interact with Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine?

Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine brand name: Hycomine Compound. Every interaction below applies to the brands too.

339 Interactions 17 Major 276 Moderate 46 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

If you've been prescribed Hycomine Compound (acetaminophen, caffeine, chlorpheniramine, hydrocodone, and phenylephrine) for a hard cough or cold, this list deserves real attention, since 17 of the 339 flagged supplements are rated major and most of those magnify what the medicine already does. Anything sedating, alcohol included, stacks onto the hydrocodone and chlorpheniramine and can slow breathing, while stimulant herbs such as ephedra pile onto the caffeine and phenylephrine, pushing heart rate and blood pressure.

Sedation is the risk I'd rank first, because an opioid plus an antihistamine already leaves little margin for extra drowsiness. Herbs that are hard on the liver add to acetaminophen's own liver load, and grapefruit or St. John's wort can shift drug levels by changing how the medicine is broken down. Most of the other 322 entries are moderate rather than major, but with five active ingredients at work, even a middling interaction has more places to land.

— , Clinical Pharmacist · July 18, 2026

Major 17 Moderate 276 Minor 46 No known interaction 1,113

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine: Top Interactions at a Glance

The Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 339 interacting ingredients — plus 1,113 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine Combinations Today

The Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Vitamin D + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrinei

Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.

Read the full interaction Minor Likelihood Probable Vitamin C + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrinei

High-dose vitamin C might slightly prolong the clearance of acetaminophen.

Read the full interaction Moderate Likelihood Possible Ashwagandha + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrinei

Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.

Read the full interaction Moderate Likelihood Possible Beet + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrinei

Theoretically, beet might increase the levels of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible Black Pepper + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrinei

Theoretically, black pepper might increase levels of drugs metabolized by CYP2D6.

Read the full interaction Moderate Likelihood Probable Caffeine + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrinei

Theoretically, concomitant use might increase stimulant adverse effects.

Read the full interaction
The complete list

Every Supplement Checked Against Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine

All 1,452 ingredients in our database, ranked by severity — 339 with a Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interaction on file and 1,113 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Vitamin D with Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.

Full Vitamin D + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine answer

Can you take Vitamin C with Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. High-dose vitamin C might slightly prolong the clearance of acetaminophen.

Full Vitamin C + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine answer

Can you take Ashwagandha with Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.

Full Ashwagandha + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine answer

Can you take Beet with Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, beet might increase the levels of CYP3A4 substrates.

Full Beet + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine answer

Can you take Black Pepper with Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black pepper might increase levels of drugs metabolized by CYP2D6.

Full Black Pepper + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine answer

Can you take Yin Chen with Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, yin chen might enhance the therapeutic and adverse effects of other CNS depressants.

Full Yin Chen + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine answer

Can you take Zedoary with Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, zedoary might increase levels of drugs metabolized by CYP3A4.

Full Zedoary + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine answer

Can you take Zizyphus with Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, zizyphus might cause additive sedative effects when taken with CNS depressants.

Full Zizyphus + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine answer

Can you take Lavender with Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.

Full Lavender + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine answer

Can you take Thyroid Extract with Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine answer

Can you take Hibiscus Sabdariffa with Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking Hibiscus sabdariffa with acetaminophen might decrease the clinical effects of acetaminophen.

Full Hibiscus Sabdariffa + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine answer

Can you take Adenosine with Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Methylxanthines are competitive antagonists of adenosine and can block its pharmacologic effects.

Full Adenosine + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine answer

Can you take Aegeline with Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Aegeline inhibits cytochrome P450 3A4 (CYP3A4) activity in vitro.

Full Aegeline + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine answer

Can you take Agar with Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine answer

Can you take Algin with Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, algin can alter the absorption of oral drugs.

Full Algin + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine answer

Can you take Aloe with Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.

Full Aloe + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine answer

Can you take Atractylodes with Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.

Full Atractylodes + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine answer

Can you take Bael with Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Bael extract and its constituent marmesinin inhibited cytochrome P450 1A2 (CYP1A2) activity in vitro.

Full Bael + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine answer

Can you take Black Psyllium with Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine answer

Can you take Blond Psyllium with Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Blond Psyllium + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine sits in 20 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine through this category.

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine through this category.

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine through this category.

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine through this category.

Anticholinergic Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine through this category.

Cytochrome P450 2E1 (Cyp2E1) Substrates 24 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

24 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine through this category.

Caffeine 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine through this category.

Glucuronidated Drugs 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine through this category.

Acetaminophen (Tylenol, Others) 8 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

8 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine through this category.

Methylxanthines 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine through this category.

Narcotic Drugs 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine through this category.

Cytochrome P450 2D6 (Cyp2D6) Inhibitors 3 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

3 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine through this category.

Alpha-Adrenergic Agonists 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine through this category.

Related: does Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine deplete any nutrients?

Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine has 2 reported nutrient associations in the research literature — see the Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

Open the label scanner

Prefer typing? The interaction checker looks up products by name too.

Products that contain Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine.

Yeast-Cleanse by Solaray contains Grapefruit Ultimate GCB by M3 Supplement Company contains Grapefruit Neuro Health by Nature’s Craft contains Grapefruit NDF Happy Peach by Bioray Kids contains Grapefruit Zi Sheng Teapills by Plum Flower contains Siberian Cocklebur Cold Away by Health Concerns contains Siberian Cocklebur Sugar Coated Bi Yan Pian by Plum Flower contains Siberian Cocklebur Pe Min Kan Wan by Plum Flower contains Siberian Cocklebur
Pharmacist Counseling Corner

Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine & Supplements: Common Questions

What supplements interact with Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine?
Our database currently documents 339 ingredients with a known Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interaction (17 major, 276 moderate, 46 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 339. The highest-ranked right now: Beer, Grapefruit, Siberian Cocklebur.
Which Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine supplement interactions are the most serious?
Focus on the major group: Beer, Grapefruit, Siberian Cocklebur, Wine and 1,4-butanediol, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine?
Plenty of supplements coexist fine with Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Hycomine Compound have the same supplement interactions as Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine?
Yes — Hycomine Compound all contain Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine deplete any vitamins or nutrients?
It might — Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine has 2 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine and my other medications?
This page covers Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine against supplements and herbal ingredients. Checking Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.