Medication interaction hub

What Supplements Interact with Caffeine (prescription drug)?

Caffeine (prescription drug) brand names: Dextrophin, Caffeine. Every interaction below applies to the brands too.

208 Interactions 7 Major 155 Moderate 46 Minor
Curated & coded by · Clinical Pharmacist · Updated October 7, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Caffeine (prescription drug)? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Caffeine (prescription drug) against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Prescription caffeine is itself a stimulant, which is exactly why this list calls for genuine care rather than a quick skim. Seven of the 208 ingredients on file are rated major, and those deserve attention first. Grapefruit can push drug levels up by blocking a clearance enzyme, and stimulant herbs like ephedra add blood pressure and heart strain to a drug that already revs the system.

Most of the 155 moderate entries do one of two things. Everyday caffeine sources, coffee among them, quietly stack more stimulant on the prescribed dose, while many herbs speed or slow the body's clearance of the drug, changing its levels. A few block absorption outright and should be taken well apart; the 46 minor entries carry less weight. If jitters, a racing heart, or lost sleep appear after adding a supplement, stacked stimulant effects are the first thing I would suspect.

— , Clinical Pharmacist · July 18, 2026

Major 7 Moderate 155 Minor 46 No known interaction 1,244

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Caffeine (prescription drug): Top Interactions at a Glance

The Caffeine (prescription drug) supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 208 interacting ingredients — plus 1,244 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Caffeine (prescription drug) Combinations Today

The Caffeine (prescription drug) + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Berberine + Caffeine (prescription drug)i

Theoretically, berberine might increase serum levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible Vitamin E + Caffeine (prescription drug)i

Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.

Read the full interaction Moderate Likelihood Probable Psilocybin + Caffeine (prescription drug)i

Theoretically, concomitant use of psilocybin with stimulant drugs might increase stimulant adverse effects.

Read the full interaction Moderate Likelihood Probable Lithium + Caffeine (prescription drug)i

Theoretically, taking lithium supplements with methylxanthines might decrease lithium levels.

Read the full interaction Moderate Likelihood Possible Bitter Orange + Caffeine (prescription drug)i

Bitter orange might increase levels of drugs metabolized by CYP3A4.

Read the full interaction Minor Likelihood Possible Ashwagandha + Caffeine (prescription drug)i

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full interaction
The complete list

Every Supplement Checked Against Caffeine (prescription drug)

All 1,452 ingredients in our database, ranked by severity — 208 with a Caffeine (prescription drug) interaction on file and 1,244 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Caffeine (prescription drug)?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Berberine with Caffeine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine might increase serum levels of drugs metabolized by CYP3A4.

Full Berberine + Caffeine (prescription drug) answer

Can you take Vitamin E with Caffeine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.

Full Vitamin E + Caffeine (prescription drug) answer

Can you take Psilocybin with Caffeine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of psilocybin with stimulant drugs might increase stimulant adverse effects.

Full Psilocybin + Caffeine (prescription drug) answer

Can you take Lithium with Caffeine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking lithium supplements with methylxanthines might decrease lithium levels.

Full Lithium + Caffeine (prescription drug) answer

Can you take Bitter Orange with Caffeine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bitter orange might increase levels of drugs metabolized by CYP3A4.

Full Bitter Orange + Caffeine (prescription drug) answer

Can you take Peppermint with Caffeine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, peppermint might increase the levels of CYP3A4 substrates.

Full Peppermint + Caffeine (prescription drug) answer

Can you take Phellodendron with Caffeine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP3A4.

Full Phellodendron + Caffeine (prescription drug) answer

Can you take Phenpromethamine with Caffeine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking phenpromethamine with stimulant drugs might have additive effects and increase the risk of adverse cardiovascular effe...

Full Phenpromethamine + Caffeine (prescription drug) answer

Can you take Propolis with Caffeine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.

Full Propolis + Caffeine (prescription drug) answer

Can you take Quercetin with Caffeine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might alter the effects and adverse effects of CYP3A4 substrates.

Full Quercetin + Caffeine (prescription drug) answer

Can you take Rabdosia Rubescens with Caffeine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that oridonin, a constituent of Rabdosia rubescens, induces cytochrome P450 3A4 (CYP3A4) enzyme.

Full Rabdosia Rubescens + Caffeine (prescription drug) answer

Can you take Raspberry Ketone with Caffeine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, raspberry ketone might increase the risk of adverse cardiovascular effects with stimulant drugs.

Full Raspberry Ketone + Caffeine (prescription drug) answer

Can you take Rauwolscine with Caffeine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rauwolscine with stimulant drugs might increase the risk of adverse stimulant effects.

Full Rauwolscine + Caffeine (prescription drug) answer

Can you take Resveratrol with Caffeine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.

Full Resveratrol + Caffeine (prescription drug) answer

Can you take Rooibos with Caffeine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rooibos with CYP1A2 substrates may increase the effects of CYP1A2 substrates.

Full Rooibos + Caffeine (prescription drug) answer

Can you take Saffron with Caffeine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, saffron might inhibit the metabolism of caffeine.

Full Saffron + Caffeine (prescription drug) answer

Can you take Sage with Caffeine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Sage + Caffeine (prescription drug) answer

Can you take Schizonepeta with Caffeine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that schizonepetin, a monoterpene constituent of schizonepeta, inhibits cytochrome P450 (CYP) 1A2.

Full Schizonepeta + Caffeine (prescription drug) answer

Can you take Securinega Suffruticosa with Caffeine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Securinega suffruticosa with stimulant drugs might increase the risk of serious adverse effects.

Full Securinega Suffruticosa + Caffeine (prescription drug) answer

Can you take Slippery Elm with Caffeine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Caffeine (prescription drug) answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Caffeine (prescription drug) is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Caffeine (prescription drug), and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Caffeine (prescription drug) sits in 7 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Caffeine (prescription drug) through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Caffeine (prescription drug) through this category.

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Caffeine (prescription drug) through this category.

Caffeine 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Caffeine (prescription drug) through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Caffeine (prescription drug) through this category.

Methylxanthines 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Caffeine (prescription drug) through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Caffeine (prescription drug) through this category.

About Caffeine (prescription drug)

Caffeine is a stimulant used as caffeine citrate (injection or oral solution) to treat apnea of prematurity in premature infants, and in over-the-counter products taken by mouth to help with tiredness and drowsiness.

Generic name: Caffeine (prescription drug)  ·  Brand names: Dextrophin, Caffeine.

See the full Caffeine drug information

Related: does Caffeine (prescription drug) deplete any nutrients?

Caffeine (prescription drug) has 2 reported nutrient associations in the research literature — see the Caffeine (prescription drug) nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Caffeine (prescription drug)

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Caffeine (prescription drug).

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Pharmacist Counseling Corner

Caffeine (prescription drug) & Supplements: Common Questions

What supplements interact with Caffeine (prescription drug)?
Our database currently documents 208 ingredients with a known Caffeine (prescription drug) interaction (7 major, 155 moderate, 46 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 208. The highest-ranked right now: Grapefruit, Activated Charcoal, Ephedra.
Which Caffeine (prescription drug) supplement interactions are the most serious?
The 7 major-rated combinations — led by Grapefruit, Activated Charcoal, Ephedra, Peyote and Rauvolfia Vomitoria — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Caffeine (prescription drug)?
Plenty of supplements coexist fine with Caffeine (prescription drug); a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Dextrophin have the same supplement interactions as Caffeine (prescription drug)?
Yes — Dextrophin, Caffeine all contain Caffeine (prescription drug), so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Caffeine (prescription drug) deplete any vitamins or nutrients?
It might — Caffeine (prescription drug) has 2 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Caffeine (prescription drug) nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Caffeine (prescription drug) and my other medications?
This page covers Caffeine (prescription drug) against supplements and herbal ingredients. Checking Caffeine (prescription drug) against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Caffeine drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 7, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.