Stone Root + Caffeine (prescription drug)
Caffeine (prescription drug) brand names: Dextrophin, Caffeine.
We found no known interaction between Stone Root and Caffeine (prescription drug) in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Stone Root and Caffeine (prescription drug)
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Caffeine (prescription drug) and Stone Root in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Stone Root at all — not against Caffeine (prescription drug), and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Stone Root safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
See Every Supplement That Interacts With Caffeine (prescription drug)
This page covers Stone Root only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Caffeine (prescription drug) page lists 208 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Ephedra (major), Grapefruit (major), Peyote (major) and Rauvolfia Vomitoria (major).
By severity: 7 major · 155 moderate · 46 minor.
From our pharmacist’s overview on the Caffeine (prescription drug) page
“Prescription caffeine is itself a stimulant, which is exactly why this list calls for genuine care rather than a quick skim. Seven of the 208 ingredients on file are rated major, and those deserve attention first.”
Reviewed by 2 · Jul 18, 2026
Taking Stone Root as Part of a Dietary Supplement Product? Check It for Interactions
We hold 18 real supplement products containing Stone Root, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Stone Root. Even though Stone Root itself has no known interaction with Caffeine (prescription drug), another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Stone Root and Caffeine (prescription drug) Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#515 of 1,452 supplements looked up here in the last 7 days
#1,287 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Stone Root reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Stone Root and Caffeine (prescription drug) records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Stone Root
What is Stone Root?
- Hemorrhoids
- Urinary and bladder discomfort
- Digestive upset
- Sore throat and hoarseness
- Kidney stones (traditional)
Stone root is a North American herb traditionally used for hemorrhoids, urinary complaints, and digestive issues. There is very little modern scientific evidence to confirm it works for any of these uses, so it should be viewed as a traditional remedy rather than a proven treatment. Talk with your pharmacist or doctor before trying it, especially if you are pregnant, breastfeeding, or take other medicines.
Collinsonia canadensis · Lamiaceae · Root and rhizome · Tincture, capsules, dried root for tea, liquid extract
An interaction check asks whether these two react with each other — it does not ask whether Stone Root is a good idea for someone in your situation. Here is what our Stone Root record says about it on its own.
Stone Root: dosing
There is no established standard dose for stone root. Traditional preparations include teas made from the dried root and alcohol-based tinctures, but reliable dosing guidelines from clinical studies do not exist.The safest approach is to follow the directions on the product label and not exceed them.
From our Stone Root monograph — the full record covers uses, side effects and every documented interaction.
About Caffeine
What Is Caffeine Used For?
Brand names: Dextrophin, Caffeine
Caffeine citrate injection and caffeine citrate oral solution are indicated for the short-term treatment of apnea of prematurity (breathing pauses in premature babies) in infants between 28 and 33 weeks gestational age. These are prescription, hospital-administered products.
Over-the-counter caffeine tablets (such as Diurex) are used by adults to temporarily reduce fatigue and drowsiness. The Earthmed Uplift Chewable products are chewable caffeine gels for adults 18 and older. Children under 12 should not use caffeine products as a substitute for sleep.
Other Drugs & Stone Root
Browse every other medication we’ve checked against Stone Root — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Stone Root against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Warfarin ›
- Methylphenidate ›
- Sertraline ›
- Losartan Potassium ›
- Testosterone ›
- Ivermectin ›
- Metoprolol ›
- Aspirin ›
- Acetaminophen ›
- Abemaciclib ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Tadalafil ›
- Docusate ›
- Tirzepatide ›
- Ibuprofen ›
- Hydroxyurea ›
- Methamphetamine ›
- Valacyclovir ›
- Warfarin Sodium ›
- Semaglutide ›
- Sumatriptan ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Amitriptyline ›
- Methotrexate ›
- Bupropion ›
- Isotretinoin ›
- Bendamustine ›
- Amlodipine Besylate ›
- Amphetamine ›
- Fluoxetine ›
- Doxycycline ›
- Acyclovir ›
- Pregabalin ›
- Lamotrigine ›
- Azithromycin ›
- Gabapentin ›
- Dextroamphetamine ›
- Acetaminophen, Codeine ›
- Quetiapine ›
- Clonazepam ›
- Methylene Blue ›
- Omeprazole ›
- Naproxen ›
- Letrozole ›
- Duloxetine ›
- Citalopram ›
- Buspirone ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Stone Root list.
Stone Root References
The 1 references that drive our Stone Root monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Caffeine (prescription drug) Is Linked to Lower Levels of One Nutrient
Natural Medicines records Caffeine (prescription drug) as a medicine that can lower these. This is not an interaction with Stone Root — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Caffeine (prescription drug) nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Stone Root and Caffeine (prescription drug) Together: Common Questions
Is it safe to take Stone Root with Caffeine (prescription drug)?
Does Caffeine (prescription drug) interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Caffeine (prescription drug) and Stone Root?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.