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Dietary supplement

Respiratory Support Ingredients & Drug Interactions

by Dr. Mercola

Capsule Category: Botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Respiratory Support is a dietary supplement by Dr. Mercola with 4 active ingredients. Its ingredients are commonly taken for cough and sore throat, dry mouth and throat irritation, digestive upset and heartburn.Based on those ingredients, 2,100 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Marshmallow Root Extract, Ivy Leaf Extract, Horehound Whole Plant Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Respiratory Support by Dr. Mercola

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains four ingredients. Three of them have linked data: Marshmallow Root Extract, Ivy Leaf Extract, and Elecampane Root Extract.

We could not check Horehound Whole Plant Extract — no monograph data is on file for it. The supplement also contains inactive ingredients (capsule material, binders, and flow agents) such as hydroxypropyl methylcellulose, rice maltodextrin, guar gum, and acacia gum.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Respiratory support.
  • We looked for evidence on: Bronchitis, Cough, Respiratory tract infections, Chest congestion, Asthma symptoms, Sore throat.
  • The closest evidence on file: Elecampane is rated "Insufficient Reliable Evidence To Rate" for Cough (Natural Medicines).
  • Also on file: English Ivy is rated "Insufficient Reliable Evidence To Rate" for Bronchitis, Respiratory tract infections, Cough.
  • Also on file: Marshmallow is rated "Insufficient Reliable Evidence To Rate" for ACE inhibitor-induced cough, Respiratory tract infections.

The evidence supporting these ingredients is limited. Marshmallow Root Extract has insufficient reliable evidence for respiratory tract infections, diarrhea, eczema, leg ulcers, and vaginal candidiasis.

Ivy Leaf Extract similarly lacks established evidence for bronchitis, respiratory tract infections, gout, nerve pain, and muscle spasticity. Elecampane Root Extract has insufficient evidence for cough and acne.

Because effectiveness data for these ingredients are not established in our records, we cannot confirm how well this product works for respiratory support.

The evidence, ingredient by ingredient Marshmallow English Ivy Elecampane White Horehound

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Marshmallow Root Extract is generally well tolerated for short-term use, but human safety data are limited, and it should be avoided during pregnancy and breastfeeding. Ivy Leaf Extract (a standardized extract) is generally well tolerated when taken by mouth, though the raw plant is toxic.

Possible side effects include abdominal pain, diarrhea, nausea, vomiting, and skin irritation. Ivy Leaf Extract should be avoided during pregnancy, and safety while breastfeeding is unknown — ask your doctor before using it if you're nursing.

Elecampane Root Extract can cause allergic reactions and stomach upset; at high doses it may cause diarrhea, vomiting, and spasms. It is likely unsafe during pregnancy and breastfeeding.

We hold no safety data on Horehound Whole Plant Extract.

Side effects, ingredient by ingredient Marshmallow English Ivy Elecampane White Horehound

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Elecampane, English Ivy, Marshmallow, White Horehound.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 2,101 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting this product, check whether you take lithium (risk of toxicity from marshmallow), drugs metabolized by liver enzymes CYP2C19, CYP2D6, or CYP2C8 (English ivy may raise their levels), blood thinners or antiplatelet drugs (marshmallow flower has minor antiplatelet effects), or CNS depressants like sleep aids and anti-anxiety medications (elecampane may add sedation). Use the search tool on this page to verify your specific medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you take lithium, any drug metabolized by CYP2C19, CYP2D6, or CYP2C8, blood thinners, or CNS depressants, you should check your medications with the tool on this page before trying this product. Pregnant and nursing women should avoid it.

If you don't have interactions and want to try it, start with short-term use and watch for stomach upset or unusual drowsiness.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Respiratory Support, straight from the product label.

Brand Dr. Mercola
Barcode (UPC) 810487039826
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Mar 22, 2024
DSLD ID 308864
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Respiratory Support by Dr. Mercola, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
810487039826
IngredientAmount% DV
Marshmallow Root Extract200 mg--
Ivy Leaf Extract50 mg--
Elecampane Root Extract200 mg--
Horehound Whole Plant Extract500 mg--

Other ingredients: Hydroxypropyl Methylcellulose, Rice Maltodextrin, Guar Gum, Gum Acacia, Agave Fiber, Rice, Agave Syrup

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Adults, as a dietary supplement, take two (2) capsules daily.

Formulation

For respiratory support

Precautions

Keep out of reach of children.

Do not use if safety seal is broken.

If you are nursing, pregnant, taking medication or have a medical condition, consult your physician before taking this product.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Dr. Mercola Providing quality products since 2001.

See for yourself

Respiratory Support by Dr. Mercola label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Respiratory Support by Dr. Mercola

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Marshmallow Root Extract

Interacts with
2,040 drugs
200 mg per serving

Marshmallow root is a traditional herb rich in soothing, gel-like fibers called mucilage, which is why it has long been used for coughs, sore throats,...

Marshmallow Root Extract monograph & interactions

Ivy Leaf Extract

Interacts with
280 drugs
50 mg per serving

English ivy leaf extract is most commonly used in cough and cold syrups to help loosen mucus and ease coughing, and it is a popular ingredient in many...

Ivy Leaf Extract monograph & interactions

Elecampane Root Extract

Interacts with
248 drugs
200 mg per serving

Elecampane is a traditional herb used mainly for coughs and other respiratory complaints, and as a bitter for digestion. Modern human evidence is very...

Elecampane Root Extract monograph & interactions

Horehound Whole Plant Extract

Interacts with
258 drugs
500 mg per serving

White horehound is a traditional bitter herb used mainly for coughs, sore throats, and mild digestive complaints, and it is a common flavoring in old-...

Horehound Whole Plant Extract monograph & interactions

Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Rice Maltodextrin, Guar Gum, Gum Acacia, Agave Fiber, Rice, Agave Syrup. These complete the product’s ingredient list but are not active constituents.

Interaction report

Respiratory Support by Dr. Mercola Drug Interactions

Want to check YOUR meds against Respiratory Support?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
2,100Drugs
661 Moderate 1,439 Minor

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Respiratory Support with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Marshmallow Root Extract3 drug types · 2,040 drugs

Lithium

Theoretically, due to potential diuretic effects, marshmallow might reduce excretion and increase levels of lithium.
Marshmallow is thought to have diuretic properties. To avoid lithium toxicity, the dose of lithium might need to be decreased when used with marshmallow.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, marshmallow flower might have antiplatelet effects.
Animal research suggests that marshmallow flower extract has antiplatelet effects. However, the root and leaf of marshmallow, not the flower, are the plant parts most commonly found in dietary supplements. Theoretically, use of marshmallow flower with anticoagulant/antiplatelet drugs can have additive effects, and might increase the risk for bleeding in some patients.

Likelihood Unlikely Evidence D
Oral Drugs

Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Marshmallow contains mucilage which can affect oral drug absorption. To avoid changes in absorption, take marshmallow 30-60 minutes after oral medications.

Likelihood Possible Evidence D

Ivy Leaf Extract3 drug types · 280 drugs

Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2C19.
In vitro research shows that English ivy inhibits CYP2C19 enzymes. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C8 (Cyp2C8) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2C8.
In vitro research shows that English ivy inhibits CYP2C8 enzymes. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.
In vitro research shows that English ivy inhibits CYP2D6 enzymes. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D

Horehound Whole Plant Extract2 drug types · 258 drugs

Antidiabetes Drugs

Evidence from animal research suggests that white horehound might lower blood glucose. However, preliminary clinical research suggests that white horehound only slightly lowers blood glucose when taken in combination with antidiabetic agents, suggesting that the effect may not be clinically significant. Until more is known, use with caution. Theoretically, white horehound may have additive effects when used by patients taking antidiabetic drugs. The dose of diabetes medications might need to be adjusted. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, metformin (Glucophage), pioglitazone (Actos), rosiglitazone (Avandia), and others.

Likelihood Possible Evidence B
Antihypertensive Drugs

Evidence from animal research suggests that taking white horehound extract lowers blood pressure. Theoretically, taking white horehound with antihypertensive drugs might enhance therapeutic effects and increase the risk of hypotension. Some antihypertensive drugs include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), Amlodipine (Norvasc), hydrochlorothiazide (HydroDiuril), furosemide (Lasix), and many others.

Likelihood Possible Evidence D

Elecampane Root Extract1 drug type · 248 drugs

Cns Depressants

Theoretically, elecampane may cause additive sedative effects when taken with CNS depressants.
Elecampane might have sedative effects.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Respiratory Support, from the product label.

Dr. Mercola

See all Dr. Mercola products
Name
NHP
Street Address
125 SW 3rd Place
City
Cape Coral
State
FL
ZipCode
33991
Phone Number
(877) 985-2696
Pharmacist Counseling Corner

Respiratory Support by Dr. Mercola: Common Questions

Does Respiratory Support by Dr. Mercola interact with any medications?
Yes. Based on its ingredients, Respiratory Support has a known interaction with 2,100 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Respiratory Support contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take while I'm pregnant?
No. Marshmallow Root Extract and Elecampane Root Extract should be avoided during pregnancy because there isn't enough safety data. Ivy Leaf Extract should also be avoided during pregnancy. Talk with your doctor before using any of these ingredients if you're pregnant or planning to become pregnant.
Can I breastfeed while taking this?
It's best to avoid it. Marshmallow Root Extract and Elecampane Root Extract lack enough safety information for breastfeeding, and safety data for Ivy Leaf Extract while nursing are unknown. Ask your doctor or pharmacist if it's okay for you.
What side effects might I notice?
Ivy Leaf Extract may cause abdominal pain, diarrhea, nausea, vomiting, or skin irritation. Elecampane can cause allergic reactions and stomach upset. Marshmallow is generally well tolerated but has limited safety data. High doses of elecampane may cause vomiting, diarrhea, or spasms.
Does this actually help with respiratory problems?
The evidence isn't established in our data. Marshmallow, Ivy Leaf, and Elecampane all lack sufficient reliable evidence for cough, respiratory tract infections, or bronchitis. We can't confirm how well this product works for respiratory support based on the safety and effectiveness data we hold.
Why does this product have so many drug interactions?
Ivy Leaf Extract can inhibit three liver enzymes that break down many medications, so it affects a broad range of drugs — even though the actual interaction hasn't been seen in humans yet. Marshmallow interacts with a few specific drug types, and elecampane adds to the sedating effects of certain medications. That's why it's important to check your exact prescriptions before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Respiratory Support is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Respiratory Support label
Sources

Sources & How We Checked

Respiratory Support's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 31 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Marshmallow 5 references
  1. Monographs on the medicinal uses of plant drugs. Exeter, UK: European Scientific Co-op Phytother, 1997.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  4. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  5. Hage-Sleiman R, Mroueh M, Daher CF. Pharmacological evaluation of aqueous extract of Althaea officinalis flower grown in Lebanon. Pharm Biol 2011;49(3):327-33.

See these in context on the Marshmallow monograph →

English Ivy 13 references
  1. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
  2. Fazio S, Pouso J, Dolinsky D, et al. Tolerance, safety and efficacy of Hedera helix extract in inflammatory bronchial diseases under clinical practice conditions: a prospective, open, multicentre postmarketing study in 9657 patients. Phytomedicine 2009;16 PubMed
  3. García M, Fernández E, Navarro JA, et al. Allergic contact dermatitis from Hedera helix L. Contact Dermatitis 1995;33(2):133-4.
  4. Hausen BM, Brohan J, Konig WA, et al. Allergic and irritant contact dermatitis from falcarinol and didehydrofalcarinol in common ivy (Hedera helix L.). Contact Dermatitis 1987;17(1):1-9.
  5. Mitchell, J. C. Allergic contact dermatitis from Hedera helix and Brassaia actinophylla (Araliaceae). Contact Dermatitis 1981;7(3):158-159.
  6. Boyle J, Harman RM. Contact dermatitis to Hedera helix (common ivy). Contact Dermatitis 1985;12(2):111-112. PubMed
  7. Yesudian PD, Franks A. Contact dermatitis from Hedera helix in a husband and wife. Contact Dermatitis 2002;46(2):125-126.
  8. Bregnbak D, Menné T, Johansen JD. Airborne contact dermatitis caused by common ivy (Hedera helix L. ssp. helix). Contact Dermatitis. 2015;72(4):243-4.
  9. Jones JM, White IR, White JM, McFadden JP. Allergic contact dermatitis to English ivy (Hedera helix)--a case series. Contact Dermatitis. 2009 Mar;60(3):179-80.
  10. Lurquin E, Swinnen I, Goossens A. Allergic contact dermatitis caused by Hedera helix arborescens and not by Hedera helix L. Contact Dermatitis. 2012;66(6):352-3.
  11. Paulsen E, Christensen LP, Andersen KE. Dermatitis from common ivy (Hedera helix L. subsp. helix) in Europe: past, present, and future. Contact Dermatitis. 2010;62(4):201-9.
  12. Rehman SU, Kim IS, Choi MS, Kim SH, Zhang Y, Yoo HH. Time-dependent Inhibition of CYP2C8 and CYP2C19 by Hedera helix Extracts, A Traditional Respiratory Herbal Medicine. Molecules. 2017;22(7). PubMed
  13. Kruttschnitt E, Wegener T, Zahner C, Henzen-Bücking S. Assessment of the Efficacy and Safety of Ivy Leaf (Hedera helix) Cough Syrup Compared with Acetylcysteine in Adults and Children with Acute Bronchitis. Evid Based Complement Alternat Med. 2020 May 4;2

See these in context on the English Ivy monograph →

Elecampane 5 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Lamminpaa A, Estlander T, Jolanki R, Kanerva L. Occupational allergic contact dermatitis caused by decorative plants. Contact Dermatitis 1996;34:330-5. PubMed
  4. Pazzaglia, M., Venturo, N., Borda, G., and Tosti, A. Contact dermatitis due to a massage liniment containing Inula helenium extract. Contact Dermatitis 1995;33(4):267.
  5. Aalto-Korte, K., Alanko, K., Kuuliala, O., and Jolanki, R. Late reactions in patch tests: a 4-year review from a clinic of occupational dermatology. Contact Dermatitis 2007;56(2):81-86. PubMed

See these in context on the Elecampane monograph →

White Horehound 8 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Roman, Ramos R., Alarcon-Aguilar, F., Lara-Lemus, A., and Flores-Saenz, J. L. Hypoglycemic effect of plants used in Mexico as antidiabetics. Arch.Med.Res 1992;23:59-64.
  5. Novaes AP, Rossi C, Poffo C, et al. Preliminary evaluation of the hypoglycemic effect of some Brazilian medicinal plants. Therapie. 2001;56(4):427-30.
  6. El Bardai, S., Lyoussi, B., Wibo, M., and Morel, N. Pharmacological evidence of hypotensive activity of Marrubium vulgare and Foeniculum vulgare in spontaneously hypertensive rat. Clin Exp Hypertens. 2001;23(4):329-343.
  7. El Bardai, S., Lyoussi, B., Wibo, M., and Morel, N. Comparative study of the antihypertensive activity of Marrubium vulgare and of the dihydropyridine calcium antagonist amlodipine in spontaneously hypertensive rat. Clin Exp Hypertens. 2004;26(6):465-474 PubMed
  8. Herrera-Arellano, A., Aguilar-Santamaria, L., Garcia-Hernandez, B., Nicasio-Torres, P., and Tortoriello, J. Clinical trial of Cecropia obtusifolia and Marrubium vulgare leaf extracts on blood glucose and serum lipids in type 2 diabetics. Phytomedicine 200 PubMed

See these in context on the White Horehound monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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