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Dietary supplement

Bergisterol Ingredients & Drug Interactions

by Nikken Wellness Kenzen

Bergisterol label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Bergisterol against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Bergisterol is a dietary supplement by Nikken Wellness Kenzen with 2 active ingredients. Its ingredients are commonly taken for high cholesterol, heart and metabolic health, anxiety and stress (aromatherapy).Based on those ingredients, 509 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bergamonte organic Citrus bergamia Risso extract, organic Amla extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Bergisterol by Nikken Wellness Kenzen

Ask about any prescription or over-the-counter medication and we check it for interactions with Bergisterol by Nikken Wellness Kenzen — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Bergisterol by Nikken Wellness Kenzen

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product has two active ingredients: bergamot extract (from the bergamia citrus fruit) and amla extract (also called Indian gooseberry). The capsule also contains inactive ingredients — HPMC and Nu-Flow — which are excipients that help form and fill the capsule.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Cardiovascular support.
  • We looked for evidence on: Cardiovascular disease (CVD), Dyslipidemia, Hypercholesterolemia, Hyperlipidemia, Hypertension, Metabolic syndrome — and 3 related terms.
  • The strongest evidence on file: Bergamot is rated "Possibly Effective" for Hyperlipidemia (Natural Medicines).
  • Also on file: Indian Gooseberry is rated "Possibly Effective" for Dyslipidemia.
  • Also on file: Bergamot is rated "Insufficient Reliable Evidence To Rate" for Metabolic syndrome.

Bergamot extract is possibly effective for high cholesterol (hyperlipidemia) based on the evidence we hold. For mental alertness, it's rated possibly ineffective.

We don't have enough reliable evidence yet to rate it for fatty liver disease or autism spectrum disorder. Amla extract is possibly effective for heartburn and acid reflux (GERD) and possibly effective for high cholesterol and related lipid problems (dyslipidemia).

For hair loss and high cholesterol alone, the evidence is insufficient to rate. Overall, the two ingredients target cholesterol and digestive comfort, though the data is strongest for the lipid effects.

The evidence, ingredient by ingredient Bergamot Indian Gooseberry

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The bergamot extract in this product appears generally well tolerated when taken by mouth short-term, though the essential oil form can be toxic if swallowed and cause sun-related skin reactions. One person in a trial reported heartburn.

The amla extract is also generally well tolerated as a food, though supplement safety is less studied; a small number of trial participants reported stomach discomfort, fatigue, or muscle and joint pain. During pregnancy, there isn't enough safety information for bergamot, so it's best to avoid it.

Safety while breastfeeding is also unknown, so avoiding it is the safer choice. For amla, there isn't enough reliable safety data for supplement doses during pregnancy, and breastfeeding safety is not well established.

Talk with your doctor or pharmacist if you're pregnant or nursing and considering this product.

Side effects, ingredient by ingredient Bergamot Indian Gooseberry

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Bergamot, Indian Gooseberry.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 509 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Bergisterol, double-check with your doctor or pharmacist if you're on blood thinners (anticoagulants), aspirin, clopidogrel (Plavix), diabetes medications, or any drugs that increase skin sensitivity to sunlight (photosensitizing drugs). Moderate interactions are documented for all of these drug types.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Bergisterol might appeal to someone looking to support cholesterol levels or digestive comfort. However, if you take blood thinners, aspirin, clopidogrel, or diabetes medications, you'll want to check with your doctor or pharmacist before starting — the interactions are real and may need dose adjustments.

Pregnant or breastfeeding women should avoid it. Discuss this product with your own healthcare provider to see if it's right for your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bergisterol, straight from the product label.

Brand Nikken Wellness Kenzen
Barcode (UPC) #17004
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Mar 22, 2023
DSLD ID 277759
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bergisterol by Nikken Wellness Kenzen, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
#17004
IngredientAmount% DV
Bergamonte organic Citrus bergamia Risso extract500 mg--
organic Amla extract124 mg--

Other ingredients: HPMC, Nu-Flow

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Recommended Use: Take two (2) capsules daily.

Precautions

If you are allergic to any of these ingredients, or are pregnant or nursing, consult a physician before taking this or any other dietary supplement.

If you are allergic to any of these ingredients, or are pregnant or nursing, consult a physician before taking this or any other dietary supplement.

Keep out of reach of children.

Do not use if safety seal under cap is broken or missing.

Storage

Store in a dry place at room temperature.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Each capsule contains 100% certified organic ingredients

Cardiovascular support

Made in USA

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Bergamonte is a registered trademark of HP ingredients Corp

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Bergisterol by Nikken Wellness Kenzen label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Bergisterol label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Bergisterol by Nikken Wellness Kenzen

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Bergamonte organic Citrus bergamia Risso extract

Interacts with
410 drugs
500 mg per serving Form: Bioflavonoids, Neoeriocitrin, Naringin, Neohesperidin, Melitidine, Bruteridine

Bergamot is a Mediterranean citrus fruit, and its standardized extract is most often used to support cholesterol and heart health, with some early but...

Bergamonte organic Citrus bergamia Risso extract monograph & interactions

Organic Amla extract

Interacts with
208 drugs
124 mg per serving

Indian gooseberry (amla) is a vitamin C-rich fruit used in Ayurvedic medicine for many purposes, from antioxidant support to cholesterol and digestion...

Organic Amla extract monograph & interactions

Other (inactive) ingredients: HPMC, Nu-Flow. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bergisterol by Nikken Wellness Kenzen Drug Interactions

Want to check YOUR meds against Bergisterol?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
509Drugs
509 Moderate

Ingredients driving the most interactions

Bergamonte organic Citrus bergamia Risso extract 410
organic Amla extract 208

Individual Drug Interactions

The ingredients in Bergisterol interact with 509 drugs. Click any drug to see the details.

2 of the 2 ingredients in Bergisterol interact with drugs. Each result below shows which ingredient is responsible. Bergamonte organic Citrus bergamia Risso extract organic Amla extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Bergisterol with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bergamonte organic Citrus bergamia Risso extract2 drug types · 410 drugs

Antidiabetes Drugs

Theoretically, taking bergamot with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that bergamot juice has hypoglycemic effects.

Likelihood Possible Evidence D
Photosensitizing Drugs

Theoretically, topical bergamot essential oil might increase the risk of side effects when used along with photosensitizing drugs.
Bergamot contains bergapten, which has photosensitizing effects.

Likelihood Probable Evidence D
Bergamonte organic Citrus bergamia Risso extract full monograph & interactions

organic Amla extract4 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, Indian gooseberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Clinical research shows that taking Indian gooseberry 500 mg as a single dose or twice daily for 10 days reduces platelet aggregation by about 24% to 36%, increases bleeding time by about 3.8-5.9 seconds, and increases clotting time by about 9.8-12.7 seconds when compared to baseline. However, taking Indian gooseberry 500 mg along with clopidogrel 75 mg or ecosprin 75 mg, as a single dose or for 10 days, does not significantly reduce platelet aggregation or increase bleeding time or clotting time when compared with clopidogrel 75 mg or ecosprin 75 mg alone. Until more is known, use caution when taking Indian gooseberry in combination with anticoagulant/antiplatelet drugs.

Likelihood Possible Evidence B
Antidiabetes Drugs

Taking Indian gooseberry with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking Indian gooseberry fruit or fruit extract alone or in conjunction with antidiabetes medications can lower blood glucose levels. Dose adjustments to diabetes medications might be necessary.

Likelihood Possible Evidence B
Aspirin

Theoretically, Indian gooseberry may increase the risk of bleeding if used with aspirin; however, research is conflicting.
Clinical research shows that taking Indian gooseberry 500 mg as a single dose or twice daily for 10 days reduces platelet aggregation by about 24% to 36%, increases bleeding time by about 3.8-5.9 seconds, and increases clotting time by about 9.8-12.7 seconds when compared to baseline. However, taking a single dose of Indian gooseberry 500 mg along with ecosprin 75 mg, or taking a combination of Indian gooseberry 500 mg twice daily plus ecosprin 75 mg once daily for 10 days, does not significantly reduce platelet aggregation or increase bleeding time or clotting time when compared with ecosprin 75 mg alone.

Likelihood Possible Evidence B
Clopidogrel (Plavix)

Theoretically, Indian gooseberry may increase the risk of bleeding if used with clopidogrel; however, research is conflicting.
Clinical research shows that taking Indian gooseberry 500 mg as a single dose or twice daily for 10 days reduces platelet aggregation by about 24% to 36%, increases bleeding time by about 3.8-5.9 seconds, and increases clotting time by about 9.8-12.7 seconds when compared to baseline. However, taking a single dose of Indian gooseberry 500 mg along with clopidogrel 75 mg, or taking a combination of Indian gooseberry 500 mg twice daily plus clopidogrel 75 mg once daily for 10 days, does not significantly reduce platelet aggregation or increase bleeding time or clotting time when compared with clopidogrel 75 mg alone.

Likelihood Possible Evidence B
organic Amla extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Bergisterol, from the product label.

Nikken Wellness Kenzen

See all Nikken Wellness Kenzen products
Name
Nikken Inc.
Street Address
18301 Von Karman Ave., Ste. 120
City
Irvine
State
CA
ZipCode
92612
Web Address
www.nikken.com
Pharmacist Counseling Corner

Bergisterol by Nikken Wellness Kenzen: Common Questions

Does Bergisterol by Nikken Wellness Kenzen interact with any medications?
Yes. Based on its ingredients, Bergisterol has a known interaction with 509 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Bergisterol contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on a blood thinner like warfarin or a drug like aspirin?
Not without checking first. The amla extract can reduce platelet clumping and raise bleeding time, which raises your bleeding risk when combined with blood thinners or aspirin. Talk to your doctor or pharmacist before starting — your dose may need adjusting.
What if I'm on diabetes medication?
Both ingredients in this product may lower blood sugar, so combining them with diabetes drugs could increase your risk of low blood sugar. Your doctor may need to adjust your medication dose if you add this supplement.
Is the bergamot extract safe to swallow?
The extract form in this capsule appears generally well tolerated short-term. However, the essential oil form can be toxic if swallowed, so stick to the supplement form and never ingest the oil.
What are the most common side effects?
Both ingredients are generally well tolerated. One person reported heartburn, and a small number reported stomach discomfort, fatigue, or muscle and joint pain in clinical trials. Topical use of bergamot can cause skin reactions, but that's not relevant to this oral capsule.
Can I take this while pregnant or breastfeeding?
No. Bergamot is best avoided during pregnancy and breastfeeding because there isn't enough safety data. Amla also lacks enough safety information for supplement doses in pregnancy and while nursing. Talk with your doctor or pharmacist for personalized advice.
Does this product actually lower cholesterol?
The bergamot extract is possibly effective for high cholesterol based on the evidence we have. The amla extract is possibly effective for high cholesterol and related lipid problems. That said, 'possibly effective' means the evidence supports it, but more research would strengthen the case.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bergisterol label
Go deeper

The Full Monographs Behind Bergisterol’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bergamot

Interacts with 410 drugs

Bergamot is a Mediterranean citrus fruit, and its standardized extract is most often used to support cholesterol and heart health, with some early but promising research. The essential oil i...

Read the full Bergamot monograph → Herb & supplement monograph

Indian Gooseberry

Interacts with 208 drugs

Indian gooseberry (amla) is a vitamin C-rich fruit used in Ayurvedic medicine for many purposes, from antioxidant support to cholesterol and digestion. Early research is promising for some u...

Read the full Indian Gooseberry monograph →
Sources

Sources & How We Checked

Bergisterol's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 23 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bergamot 17 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Naganuma M, Hirose S, Nakayama Y, et al. A study of the phototoxicity of lemon oil. Arch Dermatol Res 1985;278:31-6. . PubMed
  4. Kaddu, S., Kerl, H., and Wolf, P. Accidental bullous phototoxic reactions to bergamot aromatherapy oil. J.Am.Acad.Dermatol. 2001;45(3):458-461. PubMed
  5. Finsterer, J. Earl Grey tea intoxication. Lancet 4-27-2002;359(9316):1484. PubMed
  6. Gruson, L. M. and Chang, M. W. Berloque dermatitis mimicking child abuse. Arch.Pediatr.Adolesc.Med. 2002;156(11):1091-1093. PubMed
  7. Weisenseel, P. and Woitalla, S. [Toxic mustard plaster dematitis and phototoxic dematitis after application of bergamot oil]. MMW.Fortschr.Med. 12-15-2005;147(51-52):53, 55.
  8. Placzek, M., Fromel, W., Eberlein, B., Gilbertz, K. P., and Przybilla, B. Evaluation of phototoxic properties of fragrances. Acta Derm.Venereol. 2007;87(4):312-316. PubMed
  9. Mollace, V., Sacco, I., Janda, E., Malara, C., Ventrice, D., Colica, C., Visalli, V., Muscoli, S., Ragusa, S., Muscoli, C., Rotiroti, D., and Romeo, F. Hypolipemic and hypoglycaemic activity of bergamot polyphenols: from animal models to human studies. F PubMed
  10. Morliere, P., Huppe, G., Averbeck, D., Young, A. R., Santus, R., and Dubertret, L. In vitro photostability and photosensitizing properties of bergamot oil. Effects of a cinnamate sunscreen. J.Photochem.Photobiol.B 1990;7(2-4):199-208. PubMed
  11. Young, A. R., Walker, S. L., Kinley, J. S., Plastow, S. R., Averbeck, D., Morliere, P., and Dubertret, L. Phototumorigenesis studies of 5-methoxypsoralen in bergamot oil: evaluation and modification of risk of human use in an albino mouse skin model. J.P PubMed
  12. Girard, J., Unkovic, J., Delahayes, J., and Lafille, C. [Phototoxicity of Bergamot oil. Comparison between humans and guinea pigs]. Dermatologica 1979;158(4):229-243.
  13. Zaynoun, S. T., Johnson, B. E., and Frain-Bell, W. A study of oil of bergamot and its importance as a phototoxic agent. II. Factors which affect the phototoxic reaction induced by bergamot oil and psoralen derivatives. Contact Dermatitis 1977;3(5):225-23 PubMed
  14. Zacher, K. D. and Ippen, H. [Contact dermatitis caused by bergamot oil]. Derm.Beruf.Umwelt. 1984;32(3):95-97.
  15. Yasui, Y. and Hirone, T. Action spectrum for bergamot-oil phototoxicity measured by sunburn cell counting. J.Dermatol. 1994;21(5):319-322. PubMed
  16. Zaynoun, S. T., Johnson, B. E., and Frain-Bell, W. A study of oil of bergamot and its importance as a phototoxic agent. I. Characterization and quantification of the photoactive component. Br.J.Dermatol. 1977;96(5):475-482. PubMed
  17. Bruno A, Pandolfo G, Crucitti M, Cedro C, Zoccali RA, Muscatello MRA. Bergamot Polyphenolic Fraction Supplementation Improves Cognitive Functioning in Schizophrenia: Data From an 8-Week, Open-Label Pilot Study. J Clin Psychopharmacol 2017;37(4):468-71. PubMed

See these in context on the Bergamot monograph →

Indian Gooseberry 6 references
  1. Sabu, M. C. and Kuttan, R. Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property. J Ethnopharmacol. 2002;81(2):155-160. PubMed
  2. Fatima N, Pingali U, Muralidhar N. Study of pharmacodynamic interaction of Phyllanthus emblica extract with clopidogrel and ecosprin in patients with type II diabetes mellitus. Phytomedicine. 2014;21(5):579-85. PubMed
  3. Shanmugarajan D, Girish C, Harivenkatesh N, Chanaveerappa B, Prasanna Lakshmi NC. Antihypertensive and pleiotropic effects of Phyllanthus emblica extract as an add-on therapy in patients with essential hypertension-A randomized double-blind placebo-contro
  4. Akhtar MS, Ramzan A, Ali A, Ahmad M. Effect of amla fruit (Emblica officinalis Gaertn.) on blood glucose and lipid profile of normal subjects and type 2 diabetic patients. Int J Food Sci Nutr. 2011;62(6):609-16.
  5. Usharani P, Fatima N, Muralidhar N. Effects of Phyllanthus emblica extract on endothelial dysfunction and biomarkers of oxidative stress in patients with type 2 diabetes mellitus: a randomized, double-blind, controlled study. Diabetes Metab Syndr Obes. 20 PubMed
  6. Majeed M, Mundkur L, Paulose S, Nagabhushanam K. Novel Emblica officinalis extract containing ß-glucogallin vs. metformin: a randomized, open-label, comparative efficacy study in newly diagnosed type 2 diabetes mellitus patients with dyslipidemia. Food Fu

See these in context on the Indian Gooseberry monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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