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Chlorhexidine

Chlorhexidine is an antiseptic (germ-reducing) medicine used as a mouth rinse to treat gingivitis (gum inflammation) and as a skin product for hand scrubs, handwashing, surgical skin prep and cleansing wounds.

Brand names E-Z ScrubSupremeTru-Blu C-Hex 110Tru-Blu Chlor Hex-WashParoex +11 more
Drug class Decreased Cell Wall Integrity
Rx/OTC Forms 5
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026 Content updated Oct 2, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 70 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

✓No current FDA shortage listed · checked Oct 8, 2026 🚨Recall on record
Chlorhexidine at a glance The quick version — the full detail is in the Patient Information Guide below.
Dr. Brian Staiger, PharmD, BCPS
The Pharmacist’s Take By · Clinical pharmacist · Written

Chlorhexidine is a widely used antiseptic, on the U.S. market since the mid-1970s and available generically, used as a mouth rinse for gingivitis (red, swollen gums that bleed easily), where it fights germs and part of it clings to mouth surfaces for slow release, and in skin products for surgical scrubs, handwashing, pre-surgery skin prep and wound cleansing. Most people tolerate the rinse well, though staining of teeth and other mouth surfaces, taste changes and extra tartar are common. The one thing to watch for is a serious allergic reaction (anaphylaxis), so get emergency help right away for face or throat swelling or trouble breathing.

Clinical pearls

  • Book dental cleanings at least every six months so your dentist can remove tartar the rinse builds above the gumline.
  • Store the rinse out of small children’s reach, because swallowing a large amount can cause stomach upset or signs of alcohol intoxication.
  • Swelling in the cheek area, from inflamed salivary glands, is a reason to call your dentist or doctor.
  • Use skin products with care on premature infants and babies under 2 months, since they can cause irritation or chemical burns.
How you get itPrescription and over the counter
Comes asTopical solution, Mouth rinse, Oral solution +2
Earliest FDA record1976
Companies listing it with the FDA54
FDA label last updatedNov 6, 2023
FDA’s strongest warning (boxed)None on the label

Patient information guide A plain-language walkthrough of Chlorhexidine, written from its FDA label.

What Chlorhexidine is used for

▾

Chlorhexidine is used in different ways depending on the product.

  • Oral rinse products (such as Peridex and other chlorhexidine gluconate rinses): treat gingivitis between dental visits as part of a professional program.
  • Skin products (such as Bactoshield CHG, Antiseptic Skin Cleanser, Antiseptic Solution and Cardinal Health): surgical hand scrub, healthcare personnel handwash, patient skin prep before surgery, and skin wound and general cleansing.
  • Maxiclens 4%: surgical hand scrub, handwash, and skin wound and general skin cleansing.

How Chlorhexidine works

▾

The mouth rinse has antimicrobial activity while you rinse. Plaque tests showed lower counts of certain bacteria, both aerobic and anaerobic, through six months of use. About 30% stays in the mouth after rinsing and is released slowly.

In a six-month study, no significant bacterial resistance or overgrowth of other organisms was seen. Three months after stopping, plaque bacteria had returned to baseline levels.

Chlorhexidine dosage

▾

The oral rinse is swished in the mouth, as part of a program from your dentist. Skin products are used on the skin only, and directions vary by product.

  • Skin product directions can include timed scrubbing, rinsing and drying. Follow the label on your product.
  • Do not microwave ReadyPrep CHG cloths.

Follow your dentist or prescriber and the product label.

Dosing details from the FDA-approved label

From the Chlorhexidine prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.

  • Dry surgical sites (such as abdomen or arm) - cloth
    • Use one cloth to cleanse each 161 cm 2 area (approximately 5 x 5 inches) of skin to be prepared
    • Vigorously scrub skin back and forth for 3 minutes, completely wetting treatment area, then discard
    • Allow area to air dry for one (1) minute
    • Do not rinse
    • Use with care in premature infants or infants under 2 months of age; discard each cloth after a single use
  • Moist surgical sites (such as inguinal fold) - cloth
    • Use one cloth to cleanse each 65 cm 2 area (approximately 2 x 5 inches) of skin to be prepared
    • Vigorously scrub skin back and forth for 3 minutes, completely wetting treatment area, then discard
    • Allow area to air dry for one (1) minute
    • Do not rinse
    • Use with care in premature infants or infants under 2 months of age; discard each cloth after a single use
  • Surgical hand scrub (Bactoshield CHG, Dyna-Hex 2 solution)
    • Wet hands and forearms under running water for 30 seconds
    • Clean fingernails using a nailstick or similar cleaner
    • Scrub for 1.5 minutes with about 8 mL of product with or without a wet brush, rinse thoroughly under running water for 30 seconds, wash for an additional 1.5 minutes with 8 mL of product, rinse under running water for 30 seconds, dry thoroughly
    • Use with care in premature infants or infants under 2 months of age
  • Surgical hand scrub (Cardinal Health, Antiseptic Solution, Antiseptic Skin Cleanser solution)
    • Wet hands and forearms with water
    • Scrub for 3 minutes with about 5 mL of product and a wet brush, rinse thoroughly, wash for an additional 3 minutes with 5 mL of product and rinse under running water, dry thoroughly
    • A separate nail cleaner may be used
  • Healthcare personnel handwash
    • Wet hands with water, dispense about 5 mL of product into cupped hands and wash in a vigorous manner for 15 seconds, rinse and dry thoroughly
    • Dyna-Hex 2 label: 5 mL is 4 full pumps
  • Patient preoperative skin preparation
    • Apply product liberally to surgical site and swab for at least 2 minutes and dry with a sterile towel
    • Repeat procedure for an additional 2 minutes and dry with a sterile towel
    • Use with care in premature infants or infants under 2 months of age
  • Skin wound and general skin cleaning
    • Thoroughly rinse the area to be cleaned with water, apply the minimum amount of product necessary to cover the skin or wound area and wash gently, rinse again thoroughly
    • Use with care in premature infants or infants under 2 months of age
Read the label’s full dosing text

Directions use with care in premature infants or infants under 2 months of age. These products may cause irritation or chemical burns. Healthcare personnel handwash: wet hands with water dispense about 5 mL of product into cupped hands and wash in a vigorous manner for about 15 seconds rinse and dry thoroughly repeat procedure for an additional 2 minutes and dry with a sterile towel Skin wound and normal skin cleansing: thoroughly rinse the area to be cleaned with water apply the minimum amount of product necessary to cover the skin or wound area and wash gently rinse again thoroughly

Directions use with care in premature infants or infants under 2 months of age. These products may cause irritation or chemical burns. Healthcare personnel handwash: wet hands with water dispense about 5 mL of product into cupped hands and wash in a vigorous manner for about 15 seconds rinse and dry thoroughly Skin wound and general skin cleansing: thoroughly rinses the area to be cleaned with water apply the minimum amount of product necessary to cover the skin or wound area and wash gently rinse again thoroughly

Read the full Dosage and Administration section on DailyMed →

Chlorhexidine side effects

▾

Most side effects of the mouth rinse are local to the mouth.

Common side effects

  • Staining of teeth and other mouth surfaces
  • More tartar (calculus) buildup
  • Changes in taste
  • Mouth irritation
  • Dry mouth
  • Mouth sores or sore tongue
  • Tingling or numbness in the mouth
  • Mouth irritation or minor peeling of the mouth lining

When to get medical help

  • Get emergency help right away for signs of a serious allergic reaction (anaphylaxis). Reactions have been reported with dental products containing chlorhexidine.
  • Call your dentist or doctor if you have swelling of the salivary glands or cheek area (parotid gland swelling or sialadenitis).
  • Call your dentist or doctor if mouth irritation, sores or allergy-type symptoms develop or don't go away.
  • Get medical attention if a small child swallows a large amount of the rinse or shows signs of alcohol intoxication.

Seek help for signs of a serious allergic reaction, or for swelling or inflammation of the salivary glands.

Chlorhexidine warnings and precautions

▾
  • Serious allergic reactions, including anaphylaxis, have been reported with dental products containing chlorhexidine.
  • The rinse can increase tartar above the gumline. Your dentist should remove tartar at least every six months.
  • The effect of the rinse on periodontitis has not been determined.
  • Skin products may cause irritation or chemical burns, especially in premature infants or infants under 2 months old.

Before taking Chlorhexidine

▾
  • Do not use it if you are allergic to chlorhexidine gluconate or any ingredient in the product.
  • Tell your dentist if you have gingivitis together with periodontitis.
  • The rinse has not been tested in people with ANUG.
  • Use skin products with care in premature infants and infants under 2 months old.

Chlorhexidine overdose

▾

If a small child (about 10 kg) swallows 1 or 2 ounces of the 0.12% rinse, it might cause stomach upset, including nausea, or signs of alcohol intoxication. Get medical attention if a small child swallows more than 4 ounces or if signs of alcohol intoxication appear.

What Chlorhexidine does in the body

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In plaque samples, the rinse reduced counts of certain bacteria by about 54-97% through six months of use. The label states the clinical importance of this effect is not clear. Bacteria levels returned to baseline three months after stopping.

How your body processes Chlorhexidine

▾

About 30% of the rinse stays in the mouth after rinsing and is released slowly. Chlorhexidine is poorly absorbed from the gut. In a study, blood levels peaked 30 minutes after swallowing a dose and were undetectable by 12 hours. About 90% left the body in the stool and less than 1% in the urine.

How to store Chlorhexidine

▾

store at 20-25°C (68-77°F) avoid excessive heat above 40°C (104°F) Other information store at 20-25°C (68-77°F) avoid excessive heat above 40°C (104°F)

Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

Chlorhexidine: pharmacist answers to common questions

Quick, plain-English answers to the questions patients ask most about Chlorhexidine — the kind of thing our pharmacy team would talk through with you at the counter.

What is the mouth rinse for?

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It treats gingivitis, which means red, swollen gums that may bleed. You use it between dental visits as part of a program with your dentist. It has not been tested in people with ANUG, a severe form of gum disease.

Will it stain my teeth?

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It can. Staining of teeth and other mouth surfaces is one of the most common side effects. You may also notice more tartar and changes in taste. Your dentist should remove tartar at least every six months.

Who shouldn't use it?

▾
Anyone allergic to chlorhexidine gluconate or any ingredient in the product should avoid it. Serious allergic reactions, including anaphylaxis, have been reported with dental products containing chlorhexidine. Get emergency help if you have signs of a severe reaction.

What if my child swallows some?

▾
Keep it out of reach of children. A small child who swallows 1 or 2 ounces may have stomach upset, nausea or signs of alcohol intoxication. Get medical help if more than 4 ounces is swallowed or if signs of alcohol intoxication appear.

Are the skin products the same as the mouth rinse?

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No. Skin products are used for hand scrubs, handwashing, surgical skin prep and cleansing wounds, and directions differ by product. They may cause irritation or chemical burns, so use them with care in infants under 2 months old.

When should I call my dentist?

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Call if you have mouth irritation, sores or allergy-type symptoms that don't go away. Also call about swelling of the salivary glands or cheeks. Check in if you also have periodontitis.

Is Chlorhexidine available over the counter?

▾
Both. Some Chlorhexidine products are sold over the counter and others need a prescription. According to their FDA listings, the topical solution and topical cream, ointment or gel forms are sold both ways, at different strengths or package sizes and the mouth rinse, oral solution and buccal tablet forms need a prescription. The package says which kind you have. Your pharmacist can tell you which product is right for you.

When was Chlorhexidine first available?

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The earliest FDA record we hold for Chlorhexidine is from 1976: its first approval in Drugs@FDA or its earliest product listing in the NDC Directory, whichever is older. Many older medicines were in use before their first formal FDA approval, so this is the earliest date on record, not necessarily when Chlorhexidine was first used.

Who makes Chlorhexidine?

▾
54 companies currently list Chlorhexidine products in the FDA's NDC Directory, including Xttrium Laboratories, Inc., GOJO Industries, Inc., AVA, Inc.. That count includes repackagers and distributors as well as manufacturers (companies that sell only the raw ingredient are not counted), so fewer companies actually make it; the label on your bottle names the one that supplied yours.

Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

More about Chlorhexidine on HelloPharmacist

Detailed data & references for Chlorhexidine Forms & strengths, pricing, billing codes, manufacturers, safety reports and sourcing — the data behind the page. Most people can stop here. Each section below opens on a tap.

Chlorhexidine forms and strengths (how it comes)

Chlorhexidine is available in 5 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Need a version that does not list lactose, a gluten source, a dye or gelatin? Inactive ingredients differ by manufacturer: see Chlorhexidine inactive ingredients by manufacturer.

Topical solution

Dental · On the skin
Brands Scrub-Stat
How this form is used
What it may be used for
  • Bactoshield CHG is used as a surgical hand scrub, healthcare personnel handwash, patient preoperative skin prep, and skin wound and general skin cleansing.
  • Antiseptic Skin Cleanser and Antiseptic Solution are used for surgical hand scrub, handwash, patient preoperative skin prep, and wound and skin cleansing.
Important instructions
  • Bactoshield CHG, Antiseptic Skin Cleanser, Antiseptic Solution and Cardinal Health labels say to use with care in premature infants or infants under 2 months old, as they may cause irritation or chemical burns.
  • Cardinal Health and Antiseptic Solution labels include a timed scrub with water and rinsing for surgical hand scrub.
Available strengths 11 strengths
Show 5 more strengths Show fewer strengths
172 FDA-listed product records ⓘ

Mouth rinse

By mouth
Brands Peridex
How this form is used
What it may be used for
  • Peridex is used between dental visits, as part of a professional program, to treat gingivitis.
  • Major Oral Rinse, NUPRO Chlorhexidine Gluconate and Sky Oral Rinse labels list use between dental visits to treat gingivitis.
Available strengths 1 strength
51 FDA-listed product records ⓘ

Oral solution

By mouth
Brands Acclean Chlorhexidine Gluconate 0.12% Oral Rinse Chlorhexidine Gluconate Chlorhexidine Gluconate 0.12% Oral Rinse DASH Chlorhexidine Gluconate 0.12% Oral Rinse
How this form is used
What it may be used for
  • DASH Chlorhexidine Gluconate 0.12% Oral Rinse is used between dental visits, as part of a professional program, to treat gingivitis.
  • Acclean Chlorhexidine Gluconate 0.12% Oral Rinse labels list use between dental visits to treat gingivitis.
Available strengths 11 strengths
Show 5 more strengths Show fewer strengths
32 FDA-listed product records ⓘ

Topical cream, ointment or gel

Dental · On the skin
Brands Chlorhexidine Gluconate Major Oral Rinse ReadyPrep CHG
How this form is used
Important instructions
  • ReadyPrep CHG cloths are used to prepare the skin, and the label says not to microwave them.
  • ReadyPrep CHG is not sterile, and the label says to follow hospital policy for skin preparation with non-sterile products.
  • ReadyPrep CHG should be used with care in premature infants or infants under 2 months old, as it may cause irritation or chemical burns.
Available strengths 5 strengths
11 FDA-listed product records ⓘ

Buccal tablet

Inside the cheek
Brands Chlorhexidine Gluconate Chlorhexidine Gluconate 0.12% Oral Rinse Periogard Alcohol Free
How this form is used
What it may be used for
  • Periogard Alcohol Free is used between dental visits, as part of a professional program, to treat gingivitis.
Available strengths 2 strengths
9 FDA-listed product records ⓘ

Chlorhexidine on the U.S. market: products, makers and brands

How Chlorhexidine appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

54 companies list 112 Chlorhexidine product records with the FDA, mostly as topical solution, mouth rinse, oral solution; the earliest marketing or approval year on record is 1976. Brand names on the directory include E-Z Scrub, Supreme, Tru-Blu C-Hex 110 and 13 more; the rest are generics.

5
Dose forms ⓘ
54
Labelers (makers, repackagers, distributors)
40
Brand names
112
FDA-listed product records ⓘ
1976
Earliest FDA record ⓘ

FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

Also listed with the FDA, not a patient dose form: Powder (8) · Kit (3) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Xttrium Laboratories, Inc.24%
GOJO Industries, Inc.4%
AVA, Inc.4%
Ecolab Inc.4%
Henry Schein, Inc.4%
SC Johnson Professional USA, Inc.4%
Other makers57%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

How widely Chlorhexidine is used (Medicaid data)

A general measure of how commonly Chlorhexidine is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Chlorhexidine is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

1,373,852
Medicaid prescriptions filled (Q1–Q4 2025)
$14.4M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Chlorhexidine prescribed? Of the 1,601 medications we measure, Chlorhexidine ranks #136 by Medicaid prescriptions — more than 92% of them.

Where Chlorhexidine ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5

Utilization by Chlorhexidine product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 1.2 mg/mL mouthwash is the most-dispensed Chlorhexidine product — about 98% of these Medicaid prescriptions.

chlorhexidine gluconate 1.2 MG/ML Mouthwash Most dispensed

1,352,728 Medicaid prescriptions (Q1–Q4 2025) 98% of Chlorhexidine prescriptions shown $14M gross reimbursement (before rebates) ≈ $10 per prescription (gross)

Summed across the 17 of 122 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 834127

chlorhexidine gluconate 40 MG/ML Medicated Liquid Soap

21,124 Medicaid prescriptions (Q1–Q4 2025) 2% of Chlorhexidine prescriptions shown $320,913 gross reimbursement (before rebates) ≈ $15 per prescription (gross)

Summed across the 13 of 205 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 211365

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Chlorhexidine, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 30 of 327 listed Chlorhexidine NDCs with Medicaid activity.

Compare Chlorhexidine products

A representative set of FDA-listed product records for Chlorhexidine — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 112 of 112 products — FDA National Drug Code Directory. See every product, package size and price: browse all 112 Chlorhexidine NDCs →

Chlorhexidine recall history

A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.

The FDA’s enforcement reports list one Chlorhexidine recall since July 2021. It is still ongoing. A recall names specific lots from one company, so check the lot number on your own bottle rather than assuming every product is affected; your pharmacist can check whether your supply came from an affected lot.

Ongoing Class II Aug 18, 2026 · Sage Products, LLC
Cross Contamination with Other Products
  • 2% Chlorhexidine Gluconate* Cloth, Non-sterile, 6 Disposable cloths, Sage Products LLC, 3909 Three Oaks Road, Cary, Illinois 60013. NDC: 53462-705-26 Lots: Lot 108491 with case sequence numbers 14841 through 20013. FDA record D-0837-2026 →

Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Chlorhexidine RxCUI 2358 14 dose forms · 38 strengths
  1. Dose form (SCDF) Drug Implant RxCUI 668206 No current FDA listing
    Clinical drug / strength (SCD) gluconate 2.5 MG RxCUI 834146
  2. Dose form (SCDF) Medicated Liquid Soap RxCUI 385632 In current FDA listings
    Clinical drug / strength (SCD) gluconate 20 MG/ML RxCUI 1245230 gluconate 40 MG/ML RxCUI 211365
  3. Dose form (SCDF) Medicated Pad RxCUI 797743 No current FDA listing
    Clinical drug / strength (SCD) gluconate 1 MG/ML RxCUI 899217 gluconate 2 MG/ML RxCUI 2743367 gluconate 20 MG/ML RxCUI 846127 gluconate 30 MG/ML RxCUI 1534788 gluconate 40 MG/ML RxCUI 2677515
  4. Dose form (SCDF) Medicated Shampoo RxCUI 1092601 In current FDA listings
    Clinical drug / strength (SCD) gluconate 10 MG/ML RxCUI 1245392 gluconate 20 MG/ML RxCUI 2003745 gluconate 40 MG/ML RxCUI 1092602
  5. Dose form (SCDF) Mouthwash RxCUI 103328 In current FDA listings
    Clinical drug / strength (SCD) acetate 1 MG/ML RxCUI 2611503 gluconate 1.2 MG/ML RxCUI 834127 gluconate 2 MG/ML RxCUI 834211
  6. Dose form (SCDF) Oral Gel RxCUI 378085 In current FDA listings
    Clinical drug / strength (SCD) gluconate 0.002 MG/MG RxCUI 2590770 gluconate 0.01 MG/MG RxCUI 834295
  7. Dose form (SCDF) Oral Spray RxCUI 379320 No current FDA listing
    Clinical drug / strength (SCD) gluconate 1 MG/ML RxCUI 1299219 gluconate 2 MG/ML RxCUI 834210
  8. Dose form (SCDF) Otic Solution RxCUI 376348 No current FDA listing
    Clinical drug / strength (SCD) gluconate 1.5 MG/ML RxCUI 2568123
  9. Dose form (SCDF) Topical Cream RxCUI 377644 In current FDA listings
    Clinical drug / strength (SCD) gluconate 20 MG/ML RxCUI 2109438
  10. Dose form (SCDF) Topical Foam RxCUI 2611512 In current FDA listings
    Clinical drug / strength (SCD) acetate 20 MG/ML RxCUI 2611513 gluconate 40 MG/ML RxCUI 2675096
  11. Dose form (SCDF) Topical Gel RxCUI 378065 In current FDA listings
    Clinical drug / strength (SCD) gluconate 0.0045 MG/MG RxCUI 2568669 0.04 MG/MG RxCUI 251992
  12. Dose form (SCDF) Topical Ointment RxCUI 376471 In current FDA listings
    Clinical drug / strength (SCD) gluconate 0.02 MG/MG RxCUI 2477300
  13. Dose form (SCDF) Topical Solution RxCUI 371392 In current FDA listings
    Clinical drug / strength (SCD) gluconate 0.5 MG/ML RxCUI 834304 gluconate 1 MG/ML RxCUI 834309 gluconate 10 MG/ML RxCUI 1044470 gluconate 12 MG/ML RxCUI 1294257 gluconate 2 MG/ML RxCUI 1495080 gluconate 20 MG/ML RxCUI 834152 gluconate 200 MG/ML RxCUI 834206 gluconate 40 MG/ML RxCUI 2587890 gluconate 5 MG/ML RxCUI 834176
  14. Dose form (SCDF) Topical Spray RxCUI 379372 No current FDA listing
    Clinical drug / strength (SCD) gluconate 0.2 MG/ML RxCUI 834300 gluconate 12 MG/ML RxCUI 2723395 gluconate 40 MG/ML RxCUI 1300074 gluconate 5 MG/ML RxCUI 1435897

Look up RxCUI 2358 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

💵 What Chlorhexidine costs pharmacies (NADAC benchmark)

The national average invoice price pharmacies pay for the drug itself, from CMS's NADAC survey (data as of Sep 30, 2026). This is a supply-cost benchmark — not a retail price and not what you'd pay at the counter.

FormStrengthPharmacy acquisition benchmark
Liquid · Topical 2 g/100 mL $0.024 per mL NDC details & price history
Solution · Dental 1.2 mg/mL $0.007 per mL NDC details & price history
Why show this? Your out-of-pocket cost depends on insurance, pharmacy markup, and discounts — but the acquisition benchmark tells you whether the medication itself is inexpensive or costly, which strengths cost more per dose, and whether a cash-price quote is in a reasonable range. Each row links to the NDC-level record with its full price history.

Source: CMS National Average Drug Acquisition Cost (NADAC), a survey of retail pharmacy invoice prices. Benchmarks shown are the range across package sizes of a representative product for each form and strength — other manufacturers' products may differ.

Chlorhexidine brand names

Chlorhexidine is sold under 16 brand names in the FDA directory — E-Z Scrub, Supreme, Tru-Blu C-Hex 110, Tru-Blu Chlor Hex-Wash and others. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.

E-Z Scrub Supreme Tru-Blu C-Hex 110 Tru-Blu Chlor Hex-Wash Paroex Scrub-Stat Exidine Nupro Chlorhexidine Bactoshield Otodine Stomodine F Nolvadent Nolvasan Maxiclens Peridex Periogard

Who makes Chlorhexidine: manufacturers and labelers

54 companies list Chlorhexidine products with the FDA. By number of product records, the largest are Xttrium Laboratories, Inc., GOJO Industries, Inc., AVA, Inc.. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.

Xttrium Laboratories, Inc. 27 GOJO Industries, Inc. 5 AVA, Inc. 4 Ecolab Inc. 4 Henry Schein, Inc. 4 SC Johnson Professional USA, Inc. 4 Xinxiang Xinda Technology Co.,ltd 4 Atlantic Biologicals Corp. 3 Medline Industries, LP 3 Cardinal Health 107, LLC 2 Chartwell RX, LLC 2 Colgate Oral Pharmaceuticals, Inc. 2 NuCare Pharmaceuticals,Inc. 2 Owens & Minor, Inc. 2 PAI Holdings, LLC dba PAI Pharma 2 Rising Pharma Holdings, Inc. 2 Rite Aid 2 Sage Products LLC 2 A-S Medication Solutions 1 AmerisourceBergen Drug Corporation 1 Asclemed USA, Inc. 1 Atlantic Biologicals Corps. 1 Bajaj Medical, LLC 1 Becton Dickinson and Company 1

…and 30 more on the FDA NDC directory.

Chlorhexidine drug class (RxNorm)

Chlorhexidine belongs to the Antiinfectives and antiseptics for local oral treatment class.

Drug family (ATC) Antiinfectives and antiseptics for local oral treatment, Antiinfectives, Biguanides and amidines

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

Sources for this Chlorhexidine page

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Nov 6, 2023
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Chlorhexidine.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Chlorhexidine after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
70
Finished products in the current FDA directory
112
Companies listing them (makers, repackagers, distributors)
54
FDA labeler codes behind them ⓘ
52
Linked representative label ⓘ
Rite Aid Corporation
Linked label effective
Nov 6, 2023
Composite sections available
9
Linked SPL Set ID
12c4ced7-2ec7-3b07-e054-00144ff88e88
Linked SPL Document ID
098117db-ecc3-d9f3-e063-6394a90a05fc
Open the linked representative label on DailyMed ↗

How this page is built

HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Rite Aid Corporation is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →