Chlorhexidine
Chlorhexidine is an antiseptic (germ-reducing) medicine used as a mouth rinse to treat gingivitis (gum inflammation) and as a skin product for hand scrubs, handwashing, surgical skin prep and cleansing wounds.
🧬 Where this information comes from Click to expand
The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 70 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →
Chlorhexidine is a widely used antiseptic, on the U.S. market since the mid-1970s and available generically, used as a mouth rinse for gingivitis (red, swollen gums that bleed easily), where it fights germs and part of it clings to mouth surfaces for slow release, and in skin products for surgical scrubs, handwashing, pre-surgery skin prep and wound cleansing. Most people tolerate the rinse well, though staining of teeth and other mouth surfaces, taste changes and extra tartar are common. The one thing to watch for is a serious allergic reaction (anaphylaxis), so get emergency help right away for face or throat swelling or trouble breathing.
Clinical pearls
- Book dental cleanings at least every six months so your dentist can remove tartar the rinse builds above the gumline.
- Store the rinse out of small children’s reach, because swallowing a large amount can cause stomach upset or signs of alcohol intoxication.
- Swelling in the cheek area, from inflamed salivary glands, is a reason to call your dentist or doctor.
- Use skin products with care on premature infants and babies under 2 months, since they can cause irritation or chemical burns.
Patient information guide A plain-language walkthrough of Chlorhexidine, written from its FDA label.
What Chlorhexidine is used for
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Chlorhexidine is used in different ways depending on the product.
- Oral rinse products (such as Peridex and other chlorhexidine gluconate rinses): treat gingivitis between dental visits as part of a professional program.
- Skin products (such as Bactoshield CHG, Antiseptic Skin Cleanser, Antiseptic Solution and Cardinal Health): surgical hand scrub, healthcare personnel handwash, patient skin prep before surgery, and skin wound and general cleansing.
- Maxiclens 4%: surgical hand scrub, handwash, and skin wound and general skin cleansing.
How Chlorhexidine works
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The mouth rinse has antimicrobial activity while you rinse. Plaque tests showed lower counts of certain bacteria, both aerobic and anaerobic, through six months of use. About 30% stays in the mouth after rinsing and is released slowly.
In a six-month study, no significant bacterial resistance or overgrowth of other organisms was seen. Three months after stopping, plaque bacteria had returned to baseline levels.
Chlorhexidine dosage
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The oral rinse is swished in the mouth, as part of a program from your dentist. Skin products are used on the skin only, and directions vary by product.
- Skin product directions can include timed scrubbing, rinsing and drying. Follow the label on your product.
- Do not microwave ReadyPrep CHG cloths.
Follow your dentist or prescriber and the product label.
Dosing details from the FDA-approved label
From the Chlorhexidine prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.
- Dry surgical sites (such as abdomen or arm) - cloth
- Use one cloth to cleanse each 161 cm 2 area (approximately 5 x 5 inches) of skin to be prepared
- Vigorously scrub skin back and forth for 3 minutes, completely wetting treatment area, then discard
- Allow area to air dry for one (1) minute
- Do not rinse
- Use with care in premature infants or infants under 2 months of age; discard each cloth after a single use
- Moist surgical sites (such as inguinal fold) - cloth
- Use one cloth to cleanse each 65 cm 2 area (approximately 2 x 5 inches) of skin to be prepared
- Vigorously scrub skin back and forth for 3 minutes, completely wetting treatment area, then discard
- Allow area to air dry for one (1) minute
- Do not rinse
- Use with care in premature infants or infants under 2 months of age; discard each cloth after a single use
- Surgical hand scrub (Bactoshield CHG, Dyna-Hex 2 solution)
- Wet hands and forearms under running water for 30 seconds
- Clean fingernails using a nailstick or similar cleaner
- Scrub for 1.5 minutes with about 8 mL of product with or without a wet brush, rinse thoroughly under running water for 30 seconds, wash for an additional 1.5 minutes with 8 mL of product, rinse under running water for 30 seconds, dry thoroughly
- Use with care in premature infants or infants under 2 months of age
- Surgical hand scrub (Cardinal Health, Antiseptic Solution, Antiseptic Skin Cleanser solution)
- Wet hands and forearms with water
- Scrub for 3 minutes with about 5 mL of product and a wet brush, rinse thoroughly, wash for an additional 3 minutes with 5 mL of product and rinse under running water, dry thoroughly
- A separate nail cleaner may be used
- Healthcare personnel handwash
- Wet hands with water, dispense about 5 mL of product into cupped hands and wash in a vigorous manner for 15 seconds, rinse and dry thoroughly
- Dyna-Hex 2 label: 5 mL is 4 full pumps
- Patient preoperative skin preparation
- Apply product liberally to surgical site and swab for at least 2 minutes and dry with a sterile towel
- Repeat procedure for an additional 2 minutes and dry with a sterile towel
- Use with care in premature infants or infants under 2 months of age
- Skin wound and general skin cleaning
- Thoroughly rinse the area to be cleaned with water, apply the minimum amount of product necessary to cover the skin or wound area and wash gently, rinse again thoroughly
- Use with care in premature infants or infants under 2 months of age
Read the label’s full dosing text
Directions use with care in premature infants or infants under 2 months of age. These products may cause irritation or chemical burns. Healthcare personnel handwash: wet hands with water dispense about 5 mL of product into cupped hands and wash in a vigorous manner for about 15 seconds rinse and dry thoroughly repeat procedure for an additional 2 minutes and dry with a sterile towel Skin wound and normal skin cleansing: thoroughly rinse the area to be cleaned with water apply the minimum amount of product necessary to cover the skin or wound area and wash gently rinse again thoroughly
Directions use with care in premature infants or infants under 2 months of age. These products may cause irritation or chemical burns. Healthcare personnel handwash: wet hands with water dispense about 5 mL of product into cupped hands and wash in a vigorous manner for about 15 seconds rinse and dry thoroughly Skin wound and general skin cleansing: thoroughly rinses the area to be cleaned with water apply the minimum amount of product necessary to cover the skin or wound area and wash gently rinse again thoroughly
Read the full Dosage and Administration section on DailyMed →
Chlorhexidine side effects
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Most side effects of the mouth rinse are local to the mouth.
Common side effects
- Staining of teeth and other mouth surfaces
- More tartar (calculus) buildup
- Changes in taste
- Mouth irritation
- Dry mouth
- Mouth sores or sore tongue
- Tingling or numbness in the mouth
- Mouth irritation or minor peeling of the mouth lining
When to get medical help
- Get emergency help right away for signs of a serious allergic reaction (anaphylaxis). Reactions have been reported with dental products containing chlorhexidine.
- Call your dentist or doctor if you have swelling of the salivary glands or cheek area (parotid gland swelling or sialadenitis).
- Call your dentist or doctor if mouth irritation, sores or allergy-type symptoms develop or don't go away.
- Get medical attention if a small child swallows a large amount of the rinse or shows signs of alcohol intoxication.
Seek help for signs of a serious allergic reaction, or for swelling or inflammation of the salivary glands.
Chlorhexidine warnings and precautions
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- Serious allergic reactions, including anaphylaxis, have been reported with dental products containing chlorhexidine.
- The rinse can increase tartar above the gumline. Your dentist should remove tartar at least every six months.
- The effect of the rinse on periodontitis has not been determined.
- Skin products may cause irritation or chemical burns, especially in premature infants or infants under 2 months old.
Before taking Chlorhexidine
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- Do not use it if you are allergic to chlorhexidine gluconate or any ingredient in the product.
- Tell your dentist if you have gingivitis together with periodontitis.
- The rinse has not been tested in people with ANUG.
- Use skin products with care in premature infants and infants under 2 months old.
Chlorhexidine overdose
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If a small child (about 10 kg) swallows 1 or 2 ounces of the 0.12% rinse, it might cause stomach upset, including nausea, or signs of alcohol intoxication. Get medical attention if a small child swallows more than 4 ounces or if signs of alcohol intoxication appear.
What Chlorhexidine does in the body
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In plaque samples, the rinse reduced counts of certain bacteria by about 54-97% through six months of use. The label states the clinical importance of this effect is not clear. Bacteria levels returned to baseline three months after stopping.
How your body processes Chlorhexidine
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About 30% of the rinse stays in the mouth after rinsing and is released slowly. Chlorhexidine is poorly absorbed from the gut. In a study, blood levels peaked 30 minutes after swallowing a dose and were undetectable by 12 hours. About 90% left the body in the stool and less than 1% in the urine.
How to store Chlorhexidine
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store at 20-25°C (68-77°F) avoid excessive heat above 40°C (104°F) Other information store at 20-25°C (68-77°F) avoid excessive heat above 40°C (104°F)
Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →
Chlorhexidine: pharmacist answers to common questions
Quick, plain-English answers to the questions patients ask most about Chlorhexidine — the kind of thing our pharmacy team would talk through with you at the counter.
What is the mouth rinse for?
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Will it stain my teeth?
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Who shouldn't use it?
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What if my child swallows some?
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Are the skin products the same as the mouth rinse?
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When should I call my dentist?
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Is Chlorhexidine available over the counter?
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When was Chlorhexidine first available?
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Who makes Chlorhexidine?
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Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →
More about Chlorhexidine on HelloPharmacist
Chlorhexidine forms and strengths (how it comes)
Chlorhexidine is available in 5 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.
Need a version that does not list lactose, a gluten source, a dye or gelatin? Inactive ingredients differ by manufacturer: see Chlorhexidine inactive ingredients by manufacturer.
Topical solution
How this form is used
- Bactoshield CHG is used as a surgical hand scrub, healthcare personnel handwash, patient preoperative skin prep, and skin wound and general skin cleansing.
- Antiseptic Skin Cleanser and Antiseptic Solution are used for surgical hand scrub, handwash, patient preoperative skin prep, and wound and skin cleansing.
- Bactoshield CHG, Antiseptic Skin Cleanser, Antiseptic Solution and Cardinal Health labels say to use with care in premature infants or infants under 2 months old, as they may cause irritation or chemical burns.
- Cardinal Health and Antiseptic Solution labels include a timed scrub with water and rinsing for surgical hand scrub.
Show 5 more strengths Show fewer strengths
Mouth rinse
How this form is used
- Peridex is used between dental visits, as part of a professional program, to treat gingivitis.
- Major Oral Rinse, NUPRO Chlorhexidine Gluconate and Sky Oral Rinse labels list use between dental visits to treat gingivitis.
Oral solution
How this form is used
- DASH Chlorhexidine Gluconate 0.12% Oral Rinse is used between dental visits, as part of a professional program, to treat gingivitis.
- Acclean Chlorhexidine Gluconate 0.12% Oral Rinse labels list use between dental visits to treat gingivitis.
Show 5 more strengths Show fewer strengths
Topical cream, ointment or gel
How this form is used
- ReadyPrep CHG cloths are used to prepare the skin, and the label says not to microwave them.
- ReadyPrep CHG is not sterile, and the label says to follow hospital policy for skin preparation with non-sterile products.
- ReadyPrep CHG should be used with care in premature infants or infants under 2 months old, as it may cause irritation or chemical burns.
Buccal tablet
How this form is used
- Periogard Alcohol Free is used between dental visits, as part of a professional program, to treat gingivitis.
Chlorhexidine on the U.S. market: products, makers and brands
How Chlorhexidine appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.
54 companies list 112 Chlorhexidine product records with the FDA, mostly as topical solution, mouth rinse, oral solution; the earliest marketing or approval year on record is 1976. Brand names on the directory include E-Z Scrub, Supreme, Tru-Blu C-Hex 110 and 13 more; the rest are generics.
FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.
Also listed with the FDA, not a patient dose form: Powder (8) · Kit (3) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.
Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.
How widely Chlorhexidine is used (Medicaid data)
A general measure of how commonly Chlorhexidine is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.
Think of this as a proxy for how widely Chlorhexidine is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.
How commonly is Chlorhexidine prescribed? Of the 1,601 medications we measure, Chlorhexidine ranks #136 by Medicaid prescriptions — more than 92% of them.
Utilization by Chlorhexidine product
Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.
chlorhexidine gluconate 1.2 MG/ML Mouthwash Most dispensed
Summed across the 17 of 122 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 834127
chlorhexidine gluconate 40 MG/ML Medicated Liquid Soap
Summed across the 13 of 205 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 211365
Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.
Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Chlorhexidine, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 30 of 327 listed Chlorhexidine NDCs with Medicaid activity.
Compare Chlorhexidine products
A representative set of FDA-listed product records for Chlorhexidine — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)
| Strength | Route | Manufacturer / Labeler | Category ⓘ | Details |
|---|---|---|---|---|
| 💊Buccal tablet | ||||
| 1.2 mg/mL | Buccal | Atlantic Biologicals Corp. | ANDA | View NDC → |
| 1.2 mg/mL | Buccal | Colgate Oral Pharmaceuticals, Inc. × 2 listings | ANDA | View NDC → |
| 1.2 mg/mL | Buccal | Sage Products LLC | ANDA | View NDC → |
| 1.2 mg/mL | Buccal | VistaPharm, LLC | ANDA | View NDC → |
| 1.2 [IU]/mL | Buccal | Xttrium Laboratories, Inc. | ANDA | View NDC → |
| 💊Mouth rinse | ||||
| 1.2 mg/mL | Oral | A-S Medication Solutions | ANDA | View NDC → |
| 1.2 mg/mL | Oral | Atlantic Biologicals Corp. | ANDA | View NDC → |
| 1.2 mg/mL | Oral | Atlantic Biologicals Corps. | ANDA | View NDC → |
| 1.2 mg/mL | Oral | Benco Dental | ANDA | View NDC → |
| 1.2 mg/mL | Oral | Darby Dental Supply, LLC | ANDA | View NDC → |
| 1.2 mg/mL | Oral | Den-mat Holdings, Llc | ANDA | View NDC → |
| 1.2 mg/mL | Oral | Dentsply LLC. Professional Division Trading as "DENTSPLY Professional" | ANDA | View NDC → |
| 1.2 mg/mL | Oral | Lyne Laboratories, Inc. | ANDA | View NDC → |
| 1.2 mg/mL | Oral | McKesson | ANDA | View NDC → |
| 1.2 mg/mL | Oral | Medline Industries, LP | ANDA | View NDC → |
| 1.2 mg/mL | Oral | NuCare Pharmaceuticals,Inc. | ANDA | View NDC → |
| 1.2 mg/mL | Oral | PAI Holdings, LLC dba PAI Pharma × 2 listings | ANDA | View NDC → |
| 1.2 mg/mL | Oral | Preferred Pharmaceuticals, Inc. | ANDA | View NDC → |
| 1.2 mg/mL | Oral | Proficient Rx LP | ANDA | View NDC → |
| 1.2 mg/mL | Oral | Remedyrepack Inc. | ANDA | View NDC → |
| 1.2 mg/mL | Oral | Solventum US LLC | NDA | View NDC → |
| 1.2 mg/mL | Oral | Xttrium Laboratories, Inc. × 6 listings | ANDA | View NDC → |
| 💊Oral solution | ||||
| 1.2 mg/mL | Oral | Cardinal Health 107, LLC × 2 listings | ANDA | View NDC → |
| 1.2 mg/mL | Oral | Chartwell Governmental & Specialty RX, LLC. | ANDA | View NDC → |
| 1.2 mg/mL | Oral | Chartwell RX, LLC × 2 listings | ANDA | View NDC → |
| 1.2 mg/mL | Oral | Henry Schein, Inc. | ANDA | View NDC → |
| 1.2 mg/mL | Oral | Natco Pharma USA LLC | ANDA | View NDC → |
| 0.12 mg/mL | Oral | Xttrium Laboratories, Inc. | ANDA | View NDC → |
| 1.2 mg/mL | Oral | Xttrium Laboratories, Inc. × 2 listings | ANDA | View NDC → |
| 💊Topical cream, ointment or gel | ||||
| 1.2 mg/mL | Dental | Major Pharmaceuticals | ANDA | View NDC → |
| 500 mg | Topical | Medline Industries, LP | NDA | View NDC → |
| 500 mg | Topical | Sage Products LLC | NDA | View NDC → |
| 20 mg/mL | Topical | Xinxiang Xinda Technology Co.,ltd | OTC MONOGRAPH DRUG | View NDC → |
| 40 mg/mL | Topical | Xinxiang Xinda Technology Co.,Ltd × 2 listings | OTC MONOGRAPH DRUG | View NDC → |
| 4 g/100 mL | Cutaneous | Xinxiang Xinda Technology Co.,Ltd | OTC MONOGRAPH DRUG | View NDC → |
| 💊Topical solution | ||||
| 4 mg/100 mL | Topical | AmerisourceBergen Drug Corporation | NDA | View NDC → |
| 4 g/100 mL | Topical | Asclemed USA, Inc. | NDA | View NDC → |
| 1.2 mg/mL | Dental | Atlantic Biologicals Corp. | ANDA | View NDC → |
| 20 mg/mL | Topical | AVA, Inc. × 2 listings | NDA | View NDC → |
| 40 mg/mL | Topical | AVA, Inc. × 2 listings | NDA | View NDC → |
| 0.75 mg/100 mL | Topical | Bajaj Medical, LLC | NDA | View NDC → |
| 40 g/1000 mL | Topical | Becton Dickinson and Company | ANDA | View NDC → |
| 1.2 mg/mL | Dental | Brisk Pharmaceuticals | ANDA | View NDC → |
| 4 g/100 mL | Topical | Cardinal Health | NDA | View NDC → |
| 4 mg/100 mL | Topical | Chain Drug Marketing Association Inc. | NDA | View NDC → |
| 4 g/100 mL | Topical | Coloplast Corp | NDA | View NDC → |
| 4 g/100 mL | Topical | CVS Pharmacy, Inc. | NDA | View NDC → |
| 20 mg/mL | Topical | Ecolab Inc. × 2 listings | NDA | View NDC → |
| 40 mg/mL | Topical | Ecolab Inc. × 2 listings | NDA | View NDC → |
| 20 mg/mL | Topical | Gojo Industries, Inc. × 5 listings | NDA | View NDC → |
| 0.012 g/mL | Topical | Guangzhou Saweilan Import & Export Trading Co., Ltd | OTC MONOGRAPH DRUG | View NDC → |
| 40 mg/mL | Topical | Henry Schein, Inc. × 3 listings | NDA | View NDC → |
| 4 g/100 mL | Topical | HR Pharmaceuticals, Inc. | NDA | View NDC → |
| 4 g/100 mL | Topical | McKesson Corporation | NDA | View NDC → |
| 4 g/100 mL | Topical | McKesson Medical-Surgical | NDA | View NDC → |
| 20 mg/mL | Topical | Medline Industries, LP | NDA | View NDC → |
| 4 mg/100 mL | Topical | Meijer Distribution, Inc. | NDA | View NDC → |
| 4 g/100 mL | Topical | Molnlycke Health Care | NDA | View NDC → |
| 1.2 mg/mL | Dental | NuCare Pharmaceuticals,Inc. | ANDA | View NDC → |
| 40 mg/mL | Topical | Owens & Minor, Inc. × 2 listings | NDA | View NDC → |
| 1.2 mg/mL | Dental | Rising Pharma Holdings, Inc. | ANDA | View NDC → |
| 40 mg/mL | Topical | Rising Pharma Holdings, Inc. | NDA | View NDC → |
| 4 g/100 mL | Topical | Rite Aid × 2 listings | NDA | View NDC → |
| 4 mg/100 mL | Topical | Rite Aid Corporation | NDA | View NDC → |
| 1.2 mg/mL | Dental | Safco Dental Supply LLC | ANDA | View NDC → |
| 20 mg/mL | Topical | SC Johnson Professional USA, Inc. × 2 listings | NDA | View NDC → |
| 40 mg/mL | Topical | SC Johnson Professional USA, Inc. × 2 listings | NDA | View NDC → |
| 4 mg/100 mL | Topical | Topco Associates LLC | NDA | View NDC → |
| 4 mg/100 mL | Topical | Walgreen Co. | NDA | View NDC → |
| 2 mg/100 mL | Topical | Xttrium Laboratories, Inc. × 2 listings | NDA | View NDC → |
| 4 mg/100 mL | Topical | Xttrium Laboratories, Inc. × 4 listings | NDA | View NDC → |
| 20 mg/mL | Topical | Xttrium Laboratories, Inc. × 2 listings | NDA | View NDC → |
| 40 mg/mL | Topical | Xttrium Laboratories, Inc. | NDA | View NDC → |
| 2 g/100 mL | Topical | Xttrium Laboratories, Inc. | NDA | View NDC → |
| 4 g/100 mL | Topical | Xttrium Laboratories, Inc. × 7 listings | NDA | View NDC → |
| 💊Kits | ||||
| — | — | PureTek Corporation | UNAPPROVED DRUG OTHER | View NDC → |
Showing 112 of 112 products — FDA National Drug Code Directory. See every product, package size and price: browse all 112 Chlorhexidine NDCs →
Chlorhexidine side effects reported to the FDA (FAERS)
After a medicine reaches the market, patients, doctors and drugmakers can send the FDA reports of problems they think may be linked to it. Here’s what’s been reported for Chlorhexidine — a signal of what to watch for, not proof the drug caused it.
Source: openFDA, from the FDA Adverse Event Reporting System (FAERS). These are voluntary reports — they don’t prove the drug caused the effect, and counts reflect how often something was reported, not how often it actually happens. Reports also often name the very problem the medicine is taken for — a common reason to file one is that the drug didn’t help — so for a pain reliever you may see “pain” high on the list; that points to why the report was filed, not to the drug causing the symptom. This counts every report that lists Chlorhexidine in any role, so the total runs higher than the FDA’s official dashboard, which counts only cases where the drug is the suspect. For the authoritative figures, see the FDA FAERS Public Dashboard. Always talk to your pharmacist or doctor.
Chlorhexidine FDA approval history
How Chlorhexidine went from FDA review to the pharmacy shelf — the key milestones in its regulatory journey.
Source: Drugs@FDA.
Chlorhexidine recall history
A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.
The FDA’s enforcement reports list one Chlorhexidine recall since July 2021. It is still ongoing. A recall names specific lots from one company, so check the lot number on your own bottle rather than assuming every product is affected; your pharmacist can check whether your supply came from an affected lot.
- 2% Chlorhexidine Gluconate* Cloth, Non-sterile, 6 Disposable cloths, Sage Products LLC, 3909 Three Oaks Road, Cary, Illinois 60013. NDC: 53462-705-26 Lots: Lot 108491 with case sequence numbers 14841 through 20013. FDA record D-0837-2026 →
Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.
RxNorm Concept Web — From Ingredient to Every Form and Strength
This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.
RxCUI 2358 14 dose forms · 38 strengths
-
Dose form (SCDF) Drug Implant RxCUI 668206No current FDA listingClinical drug / strength (SCD) gluconate 2.5 MGRxCUI 834146 -
Dose form (SCDF) Medicated Liquid Soap RxCUI 385632In current FDA listings -
Dose form (SCDF) Medicated Pad RxCUI 797743No current FDA listingClinical drug / strength (SCD) gluconate 1 MG/MLRxCUI 899217gluconate 2 MG/MLRxCUI 2743367gluconate 20 MG/MLRxCUI 846127gluconate 30 MG/MLRxCUI 1534788gluconate 40 MG/MLRxCUI 2677515 -
Dose form (SCDF) Medicated Shampoo RxCUI 1092601In current FDA listingsClinical drug / strength (SCD) gluconate 10 MG/MLRxCUI 1245392gluconate 20 MG/MLRxCUI 2003745gluconate 40 MG/MLRxCUI 1092602 -
Dose form (SCDF) Mouthwash RxCUI 103328In current FDA listingsClinical drug / strength (SCD) acetate 1 MG/MLRxCUI 2611503gluconate 1.2 MG/MLRxCUI 834127gluconate 2 MG/MLRxCUI 834211 -
Dose form (SCDF) Oral Gel RxCUI 378085In current FDA listingsClinical drug / strength (SCD) gluconate 0.002 MG/MGRxCUI 2590770gluconate 0.01 MG/MGRxCUI 834295 -
Dose form (SCDF) Oral Spray RxCUI 379320No current FDA listingClinical drug / strength (SCD) gluconate 1 MG/MLRxCUI 1299219gluconate 2 MG/MLRxCUI 834210 -
Dose form (SCDF) Otic Solution RxCUI 376348No current FDA listingClinical drug / strength (SCD) gluconate 1.5 MG/MLRxCUI 2568123 -
Dose form (SCDF) Topical Cream RxCUI 377644In current FDA listingsClinical drug / strength (SCD) gluconate 20 MG/MLRxCUI 2109438 -
Dose form (SCDF) Topical Foam RxCUI 2611512In current FDA listingsClinical drug / strength (SCD) acetate 20 MG/MLRxCUI 2611513gluconate 40 MG/MLRxCUI 2675096 -
Dose form (SCDF) Topical Gel RxCUI 378065In current FDA listingsClinical drug / strength (SCD) gluconate 0.0045 MG/MGRxCUI 25686690.04 MG/MGRxCUI 251992 -
Dose form (SCDF) Topical Ointment RxCUI 376471In current FDA listingsClinical drug / strength (SCD) gluconate 0.02 MG/MGRxCUI 2477300 -
Dose form (SCDF) Topical Solution RxCUI 371392In current FDA listingsClinical drug / strength (SCD) gluconate 0.5 MG/MLRxCUI 834304gluconate 1 MG/MLRxCUI 834309gluconate 10 MG/MLRxCUI 1044470gluconate 12 MG/MLRxCUI 1294257gluconate 2 MG/MLRxCUI 1495080gluconate 20 MG/MLRxCUI 834152gluconate 200 MG/MLRxCUI 834206gluconate 40 MG/MLRxCUI 2587890gluconate 5 MG/MLRxCUI 834176 -
Dose form (SCDF) Topical Spray RxCUI 379372No current FDA listingClinical drug / strength (SCD) gluconate 0.2 MG/MLRxCUI 834300gluconate 12 MG/MLRxCUI 2723395gluconate 40 MG/MLRxCUI 1300074gluconate 5 MG/MLRxCUI 1435897
Look up RxCUI 2358 in the RxCUI Atlas →
RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.
Chlorhexidine supply and shortage status
Whether Chlorhexidine is in short supply in the U.S. right now, plus any shortage history the FDA has on record. A shortage usually reflects a manufacturing or demand issue — not a safety problem with the drug.
Source: openFDA, from the FDA Drug Shortages database.
💵 What Chlorhexidine costs pharmacies (NADAC benchmark)
The national average invoice price pharmacies pay for the drug itself, from CMS's NADAC survey (data as of Sep 30, 2026). This is a supply-cost benchmark — not a retail price and not what you'd pay at the counter.
| Form | Strength | Pharmacy acquisition benchmark | |
|---|---|---|---|
| Liquid · Topical | 2 g/100 mL | $0.024 per mL | NDC details & price history |
| Solution · Dental | 1.2 mg/mL | $0.007 per mL | NDC details & price history |
Source: CMS National Average Drug Acquisition Cost (NADAC), a survey of retail pharmacy invoice prices. Benchmarks shown are the range across package sizes of a representative product for each form and strength — other manufacturers' products may differ.
Chlorhexidine brand names
Chlorhexidine is sold under 16 brand names in the FDA directory — E-Z Scrub, Supreme, Tru-Blu C-Hex 110, Tru-Blu Chlor Hex-Wash and others. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.
Who makes Chlorhexidine: manufacturers and labelers
54 companies list Chlorhexidine products with the FDA. By number of product records, the largest are Xttrium Laboratories, Inc., GOJO Industries, Inc., AVA, Inc.. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.
…and 30 more on the FDA NDC directory.
Chlorhexidine drug class (RxNorm)
Chlorhexidine belongs to the Antiinfectives and antiseptics for local oral treatment class.
Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.
Sources for this Chlorhexidine page
Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.
How this page is built
HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Rite Aid Corporation is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →