Sky Oral Rinse Chlorhexidine Gluconate 1.2 mg/mL Rinse, 600 mL — NDC 63739-052-57 (Billing 63739-0052-57)
This is a package of 600 mL of Sky Oral Rinse Chlorhexidine Gluconate 1.2 mg/mL Rinse from McKesson, marketed since Dec 2020 and currently FDA-listed.
NDC database record
One package, one record: these facts belong to NDC 63739-052-57 alone.
- Record
- FDA NDC Directory package listing · Human prescription drug
- Code segments
- 63739 labeler · 052 product · 57 package
- Package marketed since
- Feb 15, 2021
- Sample package
- No — commercial package
- Listing certified through
- Dec 31, 2026
- Billing quantity
- 600 mL per package
- Barcode (UPC-A, from the NDC)
- 3 6373905257 4
- FDA record last changed
- Jul 24, 2026
Other active recalls for Chlorhexidine Gluconate (different manufacturers) — 1 · tap to view
Identity & classification
Regulatory identifiers FDA, NLM and CMS codes for this package
Drug-database identifiers Medi-Span GPI and First Databank GCN / HICL / AHFS classification
- GSN (GCN sequence number): 057959
- GCN: 23248
- GPI-14 (Medi-Span): 88150020102012
- HICL (First Databank): 004297
- AHFS class code: 52:04.24.00
- RxCUI (RxNorm): 834127
Where does this data come from?
- FDA openFDA NDC Directory · synced Oct 1, 2026
- FDA label on DailyMed · label index refreshed Oct 5, 2026
- RxNorm (NLM RxNav) · catalog refreshed Oct 1, 2026
- Medi-Span GPI (licensed)
- First Databank (licensed) · refreshed Oct 1, 2026
RxNorm drug class
This medicine belongs to the Antiinfectives and antiseptics for local oral treatment class.
Where does this data come from?
- RxClass (NLM) · catalog refreshed Oct 1, 2026
Clinical
- It treats gingivitis, which means red, swollen gums that may bleed. You use it between dental visits as part of a program with your dentist. It has not been tested in people with A...
- It can. Staining of teeth and other mouth surfaces is one of the most common side effects. You may also notice more tartar and changes in taste. Your dentist should remove tartar a...
- Anyone allergic to chlorhexidine gluconate or any ingredient in the product should avoid it. Serious allergic reactions, including anaphylaxis, have been reported with dental produ...
- Keep it out of reach of children. A small child who swallows 1 or 2 ounces may have stomach upset, nausea or signs of alcohol intoxication. Get medical help if more than 4 ounces i...
Patient education
Supplement & herbal interactions
Where does this data come from?
- MedlinePlus (NLM) · refreshed Oct 1, 2026
- FDA label on DailyMed · label index refreshed Oct 5, 2026
Ask a licensed pharmacist directly — free, answered by our team.
Pricing
A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.
| Price system | Per each | Per package |
|---|---|---|
| Retail pharmacies payNADAC · weekly | Not in the retail survey — common for institutional, discontinued, or low-volume packs. | |
| Medicaid paysCMS SDUD · 12 mo | No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data. | |
| Medicare drug plans payPart D · quarterly | No Part D plan price is available for this NDC in our data. | |
Where does this data come from?
- CMS NADAC weekly file
- CMS ASP pricing files · refreshed Sep 20, 2026
- CMS Medicaid State Drug Utilization Data · refreshed Oct 5, 2026
- CMS Part D plan pricing files · refreshed Sep 24, 2026
- VA National Acquisition Center price file
Packaging — all sizes for this product
| Package NDC | Description | Marketing start | Marketing end | Status |
|---|---|---|---|---|
| 63739-0052-57 You're viewing this | 600 mL in 1 PACKAGE | 2021-02-15 | — | Active |
| 63739-0052-69 63739-052-69 | 1500 mL in 1 PACKAGE | 2021-02-15 | — | Active |
| 63739-0052-74 63739-052-74 Main listing | 15 mL in 1 CUP, UNIT-DOSE | 2021-02-15 | — | Active |
You're viewing one of 3 pack sizes for this product.
Pack size FAQ
What quantity is in this package?
How does this package differ from NDC 63739-0052-74?
What NDC number is used to bill for this package of Sky Oral Rinse Chlorhexidine Gluconate 1.2 mg/mL Rinse?
Therapeutic equivalents
| Product | Labeler | Pack | NADAC/unit | TE | Status | Price vs. this |
|---|---|---|---|---|---|---|
| Chlorhexidine Gluconate Oral Rinse 1.2 mg/mL 16571-0128-48 | Rising | 473 ml | $0.007 | AT | Availability likely | — |
| Chlorhexidine Gluconate 1.2 mg/mL 00116-2001-04 | Xttrium | 118 ml | $0.017 | AT | Availability likely | — |
| Chlorhexidine Gluconate 0.12% Oral Rinse 1.2 [iU]/mL 00116-0003-15 | Xttrium | 15 ml | — | AT | FDA listed | — |
| Chlorhexidine Gluconate 1.2 mg/mL 00116-0175-16 | Xttrium | 473 ml | — | AT | FDA listed | — |
| Chlorhexidine Gluconate 1.2 mg/mL 00116-0301-15 | Xttrium | 15 ml | — | AT | FDA listed | — |
| NUPRO Chlorhexidine Gluconate 1.2 mg/mL 00116-0800-16 | Xttrium | 473 ml | — | AT | FDA listed | — |
| Acclean Chlorhexidine Gluconate 0.12% Oral Rinse 1.2 mg/mL 00116-4075-01 | Xttrium | 473 ml | — | AT | FDA listed | — |
| Chlorhexidine Gluconate 1.2 mg/mL 00116-6000-04 | Xttrium | 118 ml | — | AT | FDA listed | — |
| Acclean Chlorhexidine Gluconate 0.12% Oral Rinse 1.2 mg/mL 00116-6720-04 | Xttrium | 118 ml | — | AT | FDA listed | — |
| Chlorhexidine Gluconate 1.2 mg/mL 00121-0893-00 | PAI | 10 cups | — | AT | FDA listed | — |
| Periogard Alcohol Free 1.2 mg/mL 00126-0272-16 | Colgate | 473 ml | — | AT | FDA listed | — |
| Periogard Alcohol Free 1.2 mg/mL 00126-0282-16 | Colgate | 473 ml | — | AT | FDA listed | — |
| Chlorhexidine Gluconate 1.2 mg/mL 00374-5080-01 | Lyne | 15 ml | — | AT | FDA listed | — |
| Acclean Chlorhexidine Gluconate 0.12% Oral Rinse 1.2 mg/mL 00404-4075-01 | Henry | 473 ml | — | AT | Discontinued | — |
| Chlorhexidine Gluconate 1.2 mg/mL 00904-7035-80 | Major | 1500 ml | — | AT | FDA listed | — |
| Periogard Alcohol Free 1.2 mg/mL 17856-0272-01 | ATLANTIC | 72 cups | — | AT | FDA listed | — |
| Chlorhexidine Gluconate 1.2 mg/mL 17856-2001-03 | Atlantic | 10 ml | — | AT | FDA listed | — |
| Chlorhexidine Gluconate 1.2 mg/mL 17856-2002-03 | ATLANTIC | 15 ml | — | AT | Discontinued | — |
| Peridex 1.2 mg/mL 48878-0620-01 | Solventum | 473 ml | — | AT | FDA listed | — |
| Chlorhexidine Gluconate 1.2 mg/mL 50090-0722-00 | A-S | 473 ml | — | AT | FDA listed | — |
| Chlorhexidine Gluconate 1.2 mg/mL 53329-0301-24 | Medline | 15 ml | — | AT | FDA listed | — |
| Chlorhexidine Gluconate 0.12% Oral Rinse 1.2 mg/mL 53462-0003-15 | Sage | 15 ml | — | AT | FDA listed | — |
| DASH Chlorhexidine Gluconate 0.12% Oral Rinse 1.2 mg/mL 55154-1980-05 | Cardinal | 5 cups | — | AT | FDA listed | — |
| DASH Chlorhexidine Gluconate 0.12% Oral Rinse 1.2 mg/mL 55154-1981-05 | Cardinal | 5 cups | — | AT | FDA listed | — |
| Major Oral Rinse 1.2 mg/mL 55154-3573-05 | Cardinal | 5 cups | — | AT | FDA listed | — |
| Major Oral Rinse 1.2 mg/mL 55154-3574-05 | Cardinal | 5 cups | — | AT | FDA listed | — |
| Chlorhexidine Gluconate 1.2 mg/mL 59883-0175-16 | Den-mat | 473 ml | — | AT | FDA listed | — |
| Chlorhexidine Gluconate, 0.12% Oral Rinse 1.2 mg/mL 60687-0714-16 | American | 10 cups | — | AT | FDA listed | — |
| Chlorhexidine Gluconate, 0.12% Oral Rinse Solution 1.2 mg/mL 61037-0469-02 | Bajaj | 118 ml | — | AT | FDA listed | — |
| Chlorhexidine Gluconate 0.12% Oral Rinse 1.2 mg/mL 62135-0649-41 | Chartwell | 120 ml | — | AT | FDA listed | — |
| Chlorhexidine Gluconate 0.12% Oral Rinse 1.2 mg/mL 62135-0650-24 | Chartwell | 10 cups | — | AT | FDA listed | — |
| Chlorhexidine Gluconate 1.2 mg/mL 63187-0685-16 | Proficient | 473 ml | — | AT | FDA listed | — |
| Sky Oral Rinse 1.2 mg/mLthis 63739-0052-57 | McKesson | 600 ml | — | AT | FDA listed | — |
| NUPRO Chlorhexidine Gluconate 1.2 mg/mL 65222-0800-16 | Dentsply | 473 ml | — | AT | FDA listed | — |
| Chlorhexidine Gluconate 1.2 mg/mL 66467-2560-01 | Darby | 473 ml | — | AT | FDA listed | — |
| Chlorhexidine Gluconate 1.2 mg/mL 66689-0106-50 | VistaPharm, | 50 cups | — | AT | FDA listed | — |
| Chlorhexidine Gluconate 1.2 mg/mL 66975-0600-04 | Benco | 118 ml | — | AT | FDA listed | — |
| CleanCare Chlorhexidine Gluconate 0.12% Oral Rinse 1.2 mg/mL 67239-0225-00 | Safco | 118 ml | — | AT | FDA listed | — |
| Chlorhexidine Gluconate 1.2 mg/mL 68071-1837-06 | NuCare | 473 ml | — | AT | FDA listed | — |
| Chlorhexidine Gluconate Oral Rinse 1.2 mg/mL 68071-3630-06 | NuCare | 473 ml | — | AT | FDA listed | — |
| Chlorhexidine Gluconate 1.2 mg/mL 68788-9546-04 | Preferred | 473 ml | — | AT | FDA listed | — |
| Chlorhexidine Gluconate 0.12% Oral Rinse 1.2 mg/mL 68999-0650-24 | Chartwell | 10 cups | — | AT | FDA listed | — |
| DASH Chlorhexidine Gluconate 0.12% Oral Rinse 1.2 mg/mL 69339-0138-15 | Natco | 15 ml | — | AT | FDA listed | — |
| Chlorhexidine Gluconate 1.2 mg/mL 70518-4494-00 | REMEDYREPACK | 473 ml | — | AT | FDA listed | — |
| Chlorhexidine Gluconate, 0.12% Oral Rinse Solution 1.2 mg/mL 73141-0512-50 | A2A | 100 cups | — | AT | FDA listed | — |
| Chlorhexidine Gluconate Oral Rinse 1.2 mg/mL 73614-0203-01 | Brisk | 118 ml | — | AT | FDA listed | — |
| Chlorhexidine Gluconate, 0.12% Oral Rinse Solution 1.2 mg/mL 81033-0512-50 | Kesin | 100 cups | — | AT | FDA listed | — |
| Chlorhexidine Gluconate 1.2 mg/mL 00121-1786-16 | PAI | 473 ml | — | AT | FDA listed | — |
Where does this data come from?
- FDA openFDA NDC Directory · synced Oct 1, 2026
- FDA Orange Book · refreshed Oct 3, 2026
- CMS NADAC weekly file
Availability & generic status
This product is an FDA-approved generic. Other versions of the same drug are listed under Therapeutic equivalents, least expensive first.
Where does this data come from?
- FDA Orange Book · refreshed Oct 3, 2026
Inactive Ingredients / Excipients
Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.
Where does this data come from?
IACT rows and label-wide narrative are kept separate; availability and product-level specificity depend on the submitted label.- FDA label on DailyMed · label index refreshed Oct 5, 2026
- FDA openFDA NDC Directory · synced Oct 1, 2026
Inactive ingredient FAQ
Are inactive ingredients the same for every manufacturer?
Why might an inactive ingredient be missing?
Can inactive ingredients matter?
Manufacturer & labeler
More NDCs from McKesson labeler code 63739
- Mucus Relief Guaifenesin 600 mg Tablet, Extended Release NDC 63739-067-02
- Mirtazapine 15 mg Tablet, Film Coated NDC 63739-098-10
- Mirtazapine 30 mg Tablet, Film Coated NDC 63739-099-10
- Levetiracetam 100 mg/mL Solution NDC 63739-158-32
- Lidocaine Hydrochloride 10 mg/mL Solution NDC 63739-170-24
- Clopidogrel bisulfate 300 mg Tablet, Film Coated NDC 63739-178-30
Where does this data come from?
- FDA openFDA NDC Directory · synced Oct 1, 2026
- Drugs@FDA
Full prescribing information FDA SPL
🎯 Indications and Usage ▾
INDICATION Chlorhexidine gluconate oral rinse is indicated for use between dental visits as part of a professional program for the treatment of gingivitis as characterized by redness and swelling of the gingivae, including gingival bleeding upon probing. Chlorhexidine gluconate oral rinse has not been tested among patients with acute necrotizing ulcerative gingivitis (ANUG). For patients having coexisting gingivitis and periodontitis, see PRECAUTIONS.
⏱️ Dosage and Administration ▾
DOSAGE AND ADMINISTRATION Chlorhexidine gluconate oral rinse therapy should be initiated directly following a dental prophylaxis. Patients using chlorhexidine gluconate oral rinse should be reevaluated and given a thorough prophylaxis at intervals no longer than six months. Recommended use is twice daily rinsing for 30 seconds, morning and evening after tooth brushing.
Usual dosage is 15 ml of undiluted chlorhexidine gluconate oral rinse. Patients should be instructed to not rinse with water, or other mouthwashes, brush teeth, or eat immediately after using chlorhexidine gluconate oral rinse. Chlorhexidine gluconate oral rinse is not intended for ingestion and should be expectorated after rinsing.
⛔ Contraindications ▾
CONTRAINDICATIONS Chlorhexidine gluconate oral rinse should not be used by persons who are known to be hypersensitive to chlorhexidine gluconate or other formula ingredients.
⚠️ Warnings ▾
WARNINGS The effect of chlorhexidine gluconate oral rinse on periodontitis has not been determined. An increase in supragingival calculus was noted in clinical testing in chlorhexidine gluconate oral rinse users compared with control users. It is not known if chlorhexidine gluconate oral rinse use results in an increase in subgingival calulus.
Calculus deposits should be removed by a dental prophylaxis at intervals not greater than six months. Anaphylaxis, as well as serious allergic reactions, have been reported during postmarketing use with dental products containing chlorhexidine. SEE CONTRAINDICATIONS.
🤒 Adverse Reactions ▾
ADVERSE REACTIONS The most common side effects associated with chlohexidine gluconate oral rinses are: 1) an increase in staining of teeth and other oral surfaces; 2) an increase in calculus formation; and 3) an alteration in taste perception; see WARNINGS and PRECAUTIONS. Oral irritation and local allergy-type symptoms have been spontaneously reported as side effects associated with use of chlorhexidine gluconate oral rinse. The following oral mucosal side effects were reported during placebo-controlled adult clinical trials: aphthous ulcer, grossly obvious gingivitis, trauma, ulceration, erythema, desquamation, coated tongue, keratinization, geographic tongue, mucocele, and short frenum.
Each occured at a frequency of less than 1%. Among post marketing reports, the most frequently reported oral mucosal symptoms associated with chlorhexidine gluconate oral rinse are stomatitis, gingivitis, glossitis, ulcer, dry mouth, hypesthesia, glossal edema, and paresthesia. Minor irritation and superficial desquamation of the oral mucosa have been noted in patients using chlorhexidine gluconate oral rinse.
There have been cases of parotid gland swelling and inflammation of the salivary glands (sialadenitis) reported in patients using chlorhexidine gluconate oral rinse.
🤰 Pregnancy ▾
Pregnancy: Teratogenic Effects Reproduction studies have been performed in rats and rabbits at chlorhexidine gluconate doses up to 300mg/kg/day and 40mg/kg/day respectively, and have not revealed evidence of harm to fetus. However, adequate and well-controlled studies in pregnant women have not been done. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.
🧒 Pediatric Use ▾
Pediatric Use Clinical effectiveness and safety of chlorhexidine gluconate oral rinse have not been established in children under the age of 18.
🆘 Overdosage ▾
OVERDOSAGE Ingestion of 1 or 2 ounces of chlorhexidine gluconate oral rinse by a small child (~10kg body weight) might result in gastric distress, including nausea, or signs of alcohol intoxication. Medical attention should be sought if more than 4 ounces of chlorhexidine gluconate oral rinse is ingested by a small child or if signs of alcohol intoxication develop.
🧬 Clinical Pharmacology ▾
CLINICAL PHARMACOLOGY Chlorhexidine golconate oral rinse provides antimicrobial activity during oral rinsing. The clinical significance of chlorhexidine gluconate oral rinse's antimicrobial activities is not clear. Microbiological sampling of plaque has shown a general reduction of counts of certain assayed bacteria, both aerobic and anaerobic, ranging from 54-97% through six months use.
Use of chlorhexidine gluconate oral rinse in a six month clinical study did not result in any significant changes in bacterial resistance, overgrowth of potentially opportunistic organisms or other adverse changes in the oral microbial ecosystem. Three months after chlorhexidine gluconate oral rinse use was discontinued, the number of bacteria in plaque had returned to baseline levels and resistance of plaque bacteria to clorhexidine gluconate was equal to that at baseline.
📦 How Supplied / Storage and Handling ▾
HOW SUPPLIED Chlorhexidine gluconate oral rinse is supplied as a blue liquid in: NDC 63739-052-74 0.5-ounce (15 mL) white plastic unit dose cup NDC63739-052-57 0.5-ounce (15 mL) white plastic unit dose cups (40 pack) NDC 63739-052-69 0.5-ounce (15 mL) white plastic unit dose cups (100 pack) Store at 20°C to 25°C (68°F to 77°F), excursions permitted to 15°C to 30°C (59°F to 86°F) [see USP controlled Room Temperature].
📋 Description ▾
DESCRIPTION 0.12% chlorhexidine gluconate (CHG) is an oral rinse containing (1, 11-hexamethylene bis [5-(p-chlorophenyl) biguanide] di-D-gluconate) in a base containing water, 11.6% alcohol, glycerin, PEG-40 sorbitan diisostearate, flavor, sodium saccharin, and FD&C Blue No. 1. Chlorhexidine gluconate product is a near neutral solution (pH range 5-7).
Chlorhexidine gluconate is a salt of chlorhexidine and gluconic acid. Its chemical structure is: SKY chem structure
Medicaid utilization by pack size
Medicare Part D spend CMS · PART D · 2026 (Q1)
About this NDC listing & data coverage
What data is (and isn’t) available for this NDC — tap to expand
| NDC identity (package / product / labeler codes) | ✓ Available |
| Labeler | ✓ Available |
| Product & package description | ✓ Available |
| Marketing category & status | ✓ Available |
| Active ingredient / dosage form / route | ✓ Available |
| FDA label (SPL via DailyMed) | ✓ Available |
| Package photos | ✓ Available |
| Inactive ingredients (structured) | — Not published for this NDC The labeler did not submit a structured excipient list, or no SPL is available. |
| NADAC pharmacy acquisition price (CMS) | — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey. |
| Orange Book / therapeutic-equivalence data | ✓ Available |
| HCPCS J-code billing crosswalk | — Not published for this NDC Most self-administered / retail products have no J-code — that is normal. |
| Medicaid utilization (CMS SDUD) | — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold. |