Medication interaction hub

What Supplements Interact with Simvastatin?

Simvastatin brand name: Zocor. Every interaction below applies to the brands too.

183 Interactions 8 Major 139 Moderate 36 Minor
Curated & coded by · Clinical Pharmacist · Updated September 21, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Simvastatin? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Simvastatin against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

183 supplements and herbal ingredients have interactions with Simvastatin on file in the HelloPharmacist interaction database — 8 rated major, 139 moderate, and 36 minor. The most serious involve Apple, Grapefruit, Siberian Cocklebur, Sweet Orange and Activated Charcoal.

Our assessment: with 8 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Simvastatin.

Major 8 Moderate 139 Minor 36 No known interaction 1,269

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Simvastatin: Top Interactions at a Glance

The Simvastatin supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 183 interacting ingredients — plus 1,269 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Simvastatin Combinations Today

The Simvastatin + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Beet + Simvastatini

Theoretically, beet might increase the levels of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible Grape + Simvastatini

It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.

Read the full interaction Major Likelihood Likely Apple + Simvastatini

Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.

Read the full interaction Moderate Likelihood Probable Green Tea + Simvastatini

Theoretically, green tea might reduce the absorption of organic anion-transporting polypeptide (OATP) substrates.

Read the full interaction Moderate Likelihood Possible Turmeric + Simvastatini

Theoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.

Read the full interaction Major Likelihood Probable St. John's Wort + Simvastatini

St.

Read the full interaction
The complete list

Every Supplement Checked Against Simvastatin

All 1,452 ingredients in our database, ranked by severity — 183 with a Simvastatin interaction on file and 1,269 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Simvastatin?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Beet with Simvastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, beet might increase the levels of CYP3A4 substrates.

Full Beet + Simvastatin answer

Can you take Grape with Simvastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.

Full Grape + Simvastatin answer

Can you take Apple with Simvastatin?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.

Full Apple + Simvastatin answer

Can you take Green Tea with Simvastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, green tea might reduce the absorption of organic anion-transporting polypeptide (OATP) substrates.

Full Green Tea + Simvastatin answer

Can you take Turmeric with Simvastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Turmeric + Simvastatin answer

Can you take Berberine with Simvastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine might increase serum levels of drugs metabolized by CYP3A4.

Full Berberine + Simvastatin answer

Can you take Beta-methylphenethylamine (bmpea) with Simvastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, BMPEA might increase the levels and clinical effects of CYP3A4 substrates.

Full Beta-methylphenethylamine (bmpea) + Simvastatin answer

Can you take Bishop's Weed with Simvastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bergapten, a constituent of bishop's weed, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.

Full Bishop's Weed + Simvastatin answer

Can you take Bitter Orange with Simvastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bitter orange might increase levels of drugs metabolized by CYP3A4.

Full Bitter Orange + Simvastatin answer

Can you take Black Cohosh with Simvastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.

Full Black Cohosh + Simvastatin answer

Can you take Black Pepper with Simvastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.

Full Black Pepper + Simvastatin answer

Can you take Black Tea with Simvastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black tea might reduce the absorption of organic anion-transporting polypeptide (OATP) substrates.

Full Black Tea + Simvastatin answer

Can you take Bog Labrador Tea with Simvastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that aqueous and ethanolic extracts of Bog Labrador tea leaves can increase the concentration of cytochrome P450 3A4...

Full Bog Labrador Tea + Simvastatin answer

Can you take Boldo with Simvastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.

Full Boldo + Simvastatin answer

Can you take Boswellia Serrata with Simvastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.

Full Boswellia Serrata + Simvastatin answer

Can you take Breadfruit with Simvastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Breadfruit might increase the levels of drugs metabolized by uridine diphosphoglucuronosyl transferase (UGT).

Full Breadfruit + Simvastatin answer

Can you take Buchu with Simvastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Buchu contains pulegone, a known hepatotoxin.

Full Buchu + Simvastatin answer

Can you take Bulbine Natalensis with Simvastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Bulbine natalensis stem might reduce the levels and clinical effects of CYP3A4 substrates.

Full Bulbine Natalensis + Simvastatin answer

Can you take Caffeic Acid with Simvastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, caffeic acid might increase the levels and clinical effects of OAT1 substrates.

Full Caffeic Acid + Simvastatin answer

Can you take Calamus with Simvastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking calamus with drugs metabolized by CYP3A4 might increase drug levels and potentially increase the risk of adverse effec...

Full Calamus + Simvastatin answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Simvastatin is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Simvastatin, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Simvastatin sits in 8 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Simvastatin through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Simvastatin through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Simvastatin through this category.

Organic Anion-Transporting Polypeptide Substrates (Oatp) 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Simvastatin through this category.

Glucuronidated Drugs 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Simvastatin through this category.

Hmg-Coa Reductase Inhibitors ("Statins") 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Simvastatin through this category.

Organic Anion Transporter 1 (Oat1) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Simvastatin through this category.

Simvastatin (Zocor) 2 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

2 of the supplement ingredients on this page reach Simvastatin through this category.

About Simvastatin

Simvastatin is a statin that lowers cholesterol and triglycerides to reduce your risk of heart attack and stroke.

Generic name: Simvastatin  ·  Brand name: Zocor.

See the full Simvastatin drug information

Related: does Simvastatin deplete any nutrients?

Simvastatin has 2 reported nutrient associations in the research literature — see the Simvastatin nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Simvastatin

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Simvastatin.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

Open the label scanner

Prefer typing? The interaction checker looks up products by name too.

Pharmacist Counseling Corner

Simvastatin & Supplements: Common Questions

What supplements interact with Simvastatin?
More than you might expect — 183 in total, though they are far from equal: 8 are rated major, 139 moderate, and 36 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Apple, Grapefruit, Siberian Cocklebur.
Which Simvastatin supplement interactions are the most serious?
The 8 major-rated combinations — led by Apple, Grapefruit, Siberian Cocklebur, Sweet Orange and Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Simvastatin?
Usually yes — most people on Simvastatin can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Zocor have the same supplement interactions as Simvastatin?
Yes — Zocor all contain Simvastatin, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Simvastatin deplete any vitamins or nutrients?
It might — Simvastatin has 2 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Simvastatin nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Simvastatin and my other medications?
This page covers Simvastatin against supplements and herbal ingredients. Checking Simvastatin against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Simvastatin drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

More Free Pharmacist Tools

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 21, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.