Drug & supplement interaction

Great Plantain + Simvastatin

Simvastatin brand name: Zocor.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Great Plantain and Simvastatin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Great Plantain and Simvastatin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Simvastatin and Great Plantain in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Great Plantain safety at a glance

Great Plantain overall Use caution Generally considered well tolerated for most adults, but human safety data are limited.
Pregnancy Likely Unsafe When used orally because it can increase uterine tone. Read the full pregnancy detail
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoid medicinal amounts.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Simvastatin and Great Plantain? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Simvastatin

Interactions in our licensed database are recorded against drug classes, not just single drug names. Simvastatin is filed under 8 classifications — including hmg-coa reductase inhibitors ("statins"), organic anion-transporting polypeptide substrates (oatp), glucuronidated drugs. Great Plantain has documented interactions with 1 drug class — the most serious being warfarin (coumadin) (moderate) — and none of Simvastatin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Great Plantain Does Interact With Other Medications

Great Plantain has 2 moderate known drug interactions in our database — Simvastatin isn’t one of them. If you take anything else, check it against the full list below.

Moderate 2 No known interaction 2,828 (incl. Simvastatin)
Taking anything else?

Check Another of Your Medications Against Great Plantain

Covers the 2,830 medications we’ve checked against Great Plantain. Pick one to open its full report.

What to actually watch for

What Great Plantain Itself Has Been Linked To

This is not an interaction — nothing below involves Simvastatin. It is the side-effect record for Great Plantain on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Great Plantain, this list is the first place to look.

  • A skin rash Additional detail

    “Topically, application can cause allergic contact dermatitis in some individuals (4).”

    Great Plantain · Natural Medicines adverse-effect record, reported in dermatitis.

    1 source cited
    1. 4. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.

Everything above comes from the Natural Medicines adverse-effect record for Great Plantain — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Simvastatin’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Simvastatin column appears here.

Special populations

Great Plantain in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally because it can increase uterine tone.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Great Plantain or Simvastatin

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Great Plantain or Simvastatin, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Simvastatin

This page covers Great Plantain only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Simvastatin page lists 183 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Apple (major), Beer (major), Grapefruit (major) and Siberian Cocklebur (major).

By severity: 8 major · 139 moderate · 36 minor.

Open the Simvastatin interaction page

How much people look this up

Where Great Plantain and Simvastatin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Great Plantain
Steady interest

#977 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Simvastatin
Top half

#786 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Great Plantain reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Great Plantain and Simvastatin records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Great Plantain

What is Great Plantain?

  • Minor wounds and skin irritation
  • Insect bites and stings
  • Coughs and sore throat
  • Digestive upset
  • Mild inflammation

Great Plantain is a common weed traditionally used on the skin for minor wounds and bites, and as a tea for coughs or stomach upset. Human evidence for most of these uses is limited, though the plant appears generally well tolerated. Talk with your pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or have a health condition.

Plantago major · Plantaginaceae · Leaves and seeds · Tea, capsules, tinctures, topical salves and ointments, fresh crushed leaves (poultice)

An interaction check asks whether these two react with each other — it does not ask whether Great Plantain is a good idea for someone in your situation. Here is what our Great Plantain record says about it on its own.

Great Plantain: dosing

There is no well-established standardized dose for Great Plantain. Traditional use varies widely, and the amount of active compounds differs between products and plant sources.If you choose to use it, follow the directions on the product label and do not exceed the recommended amount. A pharmacist or doctor can help you decide whether it is appropriate for you and review your other medications and health conditions first.

From our Great Plantain monograph — the full record covers uses, side effects and every documented interaction.

Read the full Great Plantain monograph & all interactions
Medication

About Simvastatin

What Is Simvastatin Used For?

Brand name: Zocor

Simvastatin tablets are used alongside a cholesterol-lowering diet to treat high LDL cholesterol (bad cholesterol), high triglycerides, and certain inherited cholesterol disorders, including heterozygous familial hypercholesterolemia (HeFH) in adults and children aged 10 and older, and homozygous familial hypercholesterolemia (HoFH) in adults.

In adults who already have coronary heart disease, cerebrovascular disease, peripheral vascular disease, or diabetes and are at high risk for heart events, simvastatin is also used to reduce the risk of death from heart disease, non-fatal heart attack, stroke, and the need for procedures to open blocked arteries. Zocor is one brand-name product containing simvastatin and carries these same indications.

Most-Reported Side Effects for Simvastatin

From FAERS, the FDA’s public side-effect reporting system (263,006 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 14,524 reports
Nausea 14,119 reports
Dyspnea 13,226 reports
Diarrhea 12,591 reports
Dizziness 11,830 reports
See full Simvastatin drug information
Keep checking

Other Drugs & Great Plantain

Browse every other medication we’ve checked against Great Plantain — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
2Moderate
0Minor
2,827No known interaction
2 Moderate 2,827 No interaction
Moderate

2 interactions

No interaction 2,827 drugs checked — show the list

We also checked Great Plantain against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,827 medications checked with no known interaction — see the full Great Plantain list.

See the full Great Plantain interactions page
See every supplement checked against Simvastatin, ranked by severity
Evidence & sources

Great Plantain References

The 3 references that drive our Great Plantain monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Adom MB, Taher M, Mutalabisin MF, et al. Chemical constituents and medical benefits of Plantago major. Biomed Pharmacother. 2017;96:348-360. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Great Plantain and Simvastatin Together: Common Questions

Is it safe to take Great Plantain with Simvastatin?
We do not list a known interaction between Great Plantain and Simvastatin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Great Plantain and Simvastatin combination checked?
Interactions in our licensed database are recorded against drug classes. Simvastatin is filed under 8 classifications, and Great Plantain has documented interactions with 1 drug class — none of Simvastatin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Great Plantain interact with any other medications?
Yes. Great Plantain has 2 documented drug interactions in our database — Simvastatin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Simvastatin interact with any supplements?
Yes. Simvastatin has documented interactions with 183 supplements in our database — Great Plantain is not one of them. The Simvastatin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Great Plantain monograph Uses, safety profile, and every drug interaction in one place Simvastatin drug information The full plain-English guide to this medication Simvastatin supplement interactions Every supplement checked against Simvastatin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Simvastatin and Great Plantain?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.