Drug & supplement interaction

Ajuga Nipponensis + Simvastatin

Simvastatin brand name: Zocor.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Ajuga Nipponensis and Simvastatin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Ajuga Nipponensis and Simvastatin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Simvastatin and Ajuga Nipponensis in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Ajuga Nipponensis at all — not against Simvastatin, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Ajuga Nipponensis safety at a glance

Ajuga Nipponensis overall Not established There is not enough reliable human data to judge its safety.
Pregnancy Avoid Safety has not been studied, so it is best avoided during pregnancy.
Breastfeeding Avoid No safety data exists for breastfeeding, so avoid use.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Simvastatin and Ajuga Nipponensis? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Ajuga Nipponensis and Simvastatin May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Nausea / Vomiting reported in 5.3% of FDA reports for Simvastatin Additional detail

    Ajuga Nipponensis

    “Orally, Ajuga nipponensis has been reported to cause diarrhea, nausea, and vomiting.”

    Ajuga Nipponensis · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 14070. Liao SC, Chiu TF, Chen JC, Lin CC. Ajuga nipponensis Makino poisoning. Clin Toxicol (Phila) 2005;43:583-5.

    Simvastatin

    Listed in the ADVERSE REACTIONS section of the FDA label for Simvastatin, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Ajuga Nipponensis but not commonly for Simvastatin: kidney problems and diarrhea.

Effects for Simvastatin come from the ADVERSE REACTIONS section of its FDA label; effects for Ajuga Nipponensis come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 261,345 voluntary FDA FAERS reports for Simvastatin that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

From our Q&A

Questions About Ajuga Nipponensis or Simvastatin

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Ajuga Nipponensis or Simvastatin, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Simvastatin

This page covers Ajuga Nipponensis only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Simvastatin page lists 183 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Apple (major), Beer (major), Grapefruit (major) and Siberian Cocklebur (major).

By severity: 8 major · 139 moderate · 36 minor.

Open the Simvastatin interaction page

How much people look this up

Where Ajuga Nipponensis and Simvastatin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Ajuga Nipponensis
Steady interest

#1,368 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Simvastatin
Top 25%

#619 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Ajuga Nipponensis reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Ajuga Nipponensis and Simvastatin records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Ajuga Nipponensis

What is Ajuga Nipponensis?

Ajuga Nipponensis
  • Cough and respiratory symptoms
  • Sore throat
  • Fever
  • Inflammation
  • Traditional general wellness

Ajuga nipponensis is a perennial plant from East Asia used in traditional medicine for cough and respiratory complaints. There is very little human research to confirm any health benefits, so its effectiveness and safety remain largely unknown. Talk to a pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or taking other medicines.

Ajuga nipponensis · Lamiaceae · Whole plant, leaves, and aerial parts · Dried herb, tea, traditional decoctions, extracts

An interaction check asks whether these two react with each other — it does not ask whether Ajuga Nipponensis is a good idea for someone in your situation. Here is what our Ajuga Nipponensis record says about it on its own.

Ajuga Nipponensis: dosing

There is no established or standardized dose for Ajuga nipponensis. Scientists have not determined a safe and effective amount for any condition.If you choose to use a product that contains it, follow the directions on the label and do not exceed them.

From our Ajuga Nipponensis monograph — the full record covers uses, side effects and every documented interaction.

Read the full Ajuga Nipponensis monograph & all interactions
Medication

About Simvastatin

What Is Simvastatin Used For?

Brand name: Zocor

Simvastatin tablets are used alongside a cholesterol-lowering diet to treat high LDL cholesterol (bad cholesterol), high triglycerides, and certain inherited cholesterol disorders, including heterozygous familial hypercholesterolemia (HeFH) in adults and children aged 10 and older, and homozygous familial hypercholesterolemia (HoFH) in adults.

In adults who already have coronary heart disease, cerebrovascular disease, peripheral vascular disease, or diabetes and are at high risk for heart events, simvastatin is also used to reduce the risk of death from heart disease, non-fatal heart attack, stroke, and the need for procedures to open blocked arteries. Zocor is one brand-name product containing simvastatin and carries these same indications.

Most-Reported Side Effects for Simvastatin

From FAERS, the FDA’s public side-effect reporting system (263,006 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 14,524 reports
Nausea 14,119 reports
Dyspnea 13,226 reports
Diarrhea 12,591 reports
Dizziness 11,830 reports
See full Simvastatin drug information
Keep checking

Other Drugs & Ajuga Nipponensis

Browse every other medication we’ve checked against Ajuga Nipponensis — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Ajuga Nipponensis against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Ajuga Nipponensis list.

See the full Ajuga Nipponensis interactions page
See every supplement checked against Simvastatin, ranked by severity
Evidence & sources

Ajuga Nipponensis References

The 1 references that drive our Ajuga Nipponensis monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Liao SC, Chiu TF, Chen JC, Lin CC. Ajuga nipponensis Makino poisoning. Clin Toxicol (Phila) 2005;43:583-5.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Ajuga Nipponensis and Simvastatin Together: Common Questions

Is it safe to take Ajuga Nipponensis with Simvastatin?
We do not list a known interaction between Ajuga Nipponensis and Simvastatin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Ajuga Nipponensis and Simvastatin have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Simvastatin interact with any supplements?
Yes. Simvastatin has documented interactions with 183 supplements in our database — Ajuga Nipponensis is not one of them. The Simvastatin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Ajuga Nipponensis monograph Uses, safety profile, and every drug interaction in one place Simvastatin drug information The full plain-English guide to this medication Simvastatin supplement interactions Every supplement checked against Simvastatin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Simvastatin and Ajuga Nipponensis?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.