Medication interaction hub

What Supplements Interact with Lovastatin?

Lovastatin brand names: Mevacor, Altocor. Every interaction below applies to the brands too.

184 Interactions 8 Major 140 Moderate 36 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Lovastatin? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Lovastatin against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Lovastatin (Mevacor) lowers cholesterol, and the liver clears it through an enzyme called CYP3A4, which is where most of these 184 supplements collide with it. This list deserves careful attention. Eight entries rate major, grapefruit chief among them, since it blocks CYP3A4 and can push lovastatin levels high enough to raise the risk of side effects, while St. John's wort does the reverse, speeding the drug's breakdown so it protects less.

The 121 CYP3A4 entries give the list its shape, but 38 ingredients add liver strain on top of a drug the liver already handles, and 17 interfere with a transporter (OATP) that helps oral drugs get absorbed. Most of the 184 rate moderate (140) or minor (36), yet the eight majors are where your reading should begin. Red yeast rice earns a special mention because it naturally contains lovastatin, so taking both stacks the same statin twice.

— , Clinical Pharmacist · July 18, 2026

Major 8 Moderate 140 Minor 36 No known interaction 1,268

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Lovastatin: Top Interactions at a Glance

The Lovastatin supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 184 interacting ingredients — plus 1,268 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Lovastatin Combinations Today

The Lovastatin + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Probable Green Tea + Lovastatini

Theoretically, green tea might reduce the absorption of organic anion-transporting polypeptide (OATP) substrates.

Read the full interaction Moderate Likelihood Possible Slippery Elm + Lovastatini

Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Read the full interaction Moderate Likelihood Possible Tragacanth + Lovastatini

Theoretically, tragacanth might alter absorption of oral drugs.

Read the full interaction Moderate Likelihood Possible Hemp Agrimony + Lovastatini

Hemp agrimony contains hepatotoxic pyrrolizidine alkaloids (PA).

Read the full interaction Moderate Likelihood Possible Fennel + Lovastatini

Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible Cannabinol (cbn) + Lovastatini

Theoretically, CYP2C9 inhibitors might increase the levels and clinical effects of cannabinol.

Read the full interaction
The complete list

Every Supplement Checked Against Lovastatin

All 1,452 ingredients in our database, ranked by severity — 184 with a Lovastatin interaction on file and 1,268 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Lovastatin?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Green Tea with Lovastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, green tea might reduce the absorption of organic anion-transporting polypeptide (OATP) substrates.

Full Green Tea + Lovastatin answer

Can you take Slippery Elm with Lovastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Lovastatin answer

Can you take Tragacanth with Lovastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Lovastatin answer

Can you take Hemp Agrimony with Lovastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Hemp agrimony contains hepatotoxic pyrrolizidine alkaloids (PA).

Full Hemp Agrimony + Lovastatin answer

Can you take Fennel with Lovastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.

Full Fennel + Lovastatin answer

Can you take Ashwagandha with Lovastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.

Full Ashwagandha + Lovastatin answer

Can you take Astaxanthin with Lovastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.

Full Astaxanthin + Lovastatin answer

Can you take Ayahuasca with Lovastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ayahuasca might increase plasma concentrations of CYP3A4 substrates.

Full Ayahuasca + Lovastatin answer

Can you take Bacopa with Lovastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.

Full Bacopa + Lovastatin answer

Can you take Banaba with Lovastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of banaba with substrates of OATP might reduce the bioavailability of the OATP substrate.

Full Banaba + Lovastatin answer

Can you take Beet with Lovastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, beet might increase the levels of CYP3A4 substrates.

Full Beet + Lovastatin answer

Can you take Berberine with Lovastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine might increase serum levels of drugs metabolized by CYP3A4.

Full Berberine + Lovastatin answer

Can you take Beta-methylphenethylamine (bmpea) with Lovastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, BMPEA might increase the levels and clinical effects of CYP3A4 substrates.

Full Beta-methylphenethylamine (bmpea) + Lovastatin answer

Can you take Bishop's Weed with Lovastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bergapten, a constituent of bishop's weed, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.

Full Bishop's Weed + Lovastatin answer

Can you take Bitter Orange with Lovastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bitter orange might increase levels of drugs metabolized by CYP3A4.

Full Bitter Orange + Lovastatin answer

Can you take Black Cohosh with Lovastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.

Full Black Cohosh + Lovastatin answer

Can you take Black Pepper with Lovastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.

Full Black Pepper + Lovastatin answer

Can you take Black Tea with Lovastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black tea might reduce the absorption of organic anion-transporting polypeptide (OATP) substrates.

Full Black Tea + Lovastatin answer

Can you take Bog Labrador Tea with Lovastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that aqueous and ethanolic extracts of Bog Labrador tea leaves can increase the concentration of cytochrome P450 3A4...

Full Bog Labrador Tea + Lovastatin answer

Can you take Boldo with Lovastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.

Full Boldo + Lovastatin answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Lovastatin is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Lovastatin, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Lovastatin sits in 8 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Lovastatin through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Lovastatin through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Lovastatin through this category.

Organic Anion-Transporting Polypeptide Substrates (Oatp) 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Lovastatin through this category.

Glucuronidated Drugs 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Lovastatin through this category.

Hmg-Coa Reductase Inhibitors ("Statins") 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Lovastatin through this category.

Cytochrome P450 2C9 (Cyp2C9) Inhibitors 4 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

4 of the supplement ingredients on this page reach Lovastatin through this category.

Lovastatin (Mevacor) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Lovastatin through this category.

About Lovastatin

Lovastatin is a statin that lowers cholesterol and reduces the risk of heart attack and stroke.

Generic name: Lovastatin  ·  Brand names: Mevacor, Altocor.

See the full Lovastatin drug information

Related: does Lovastatin deplete any nutrients?

Lovastatin has 2 reported nutrient associations in the research literature — see the Lovastatin nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Lovastatin

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Lovastatin.

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Pharmacist Counseling Corner

Lovastatin & Supplements: Common Questions

What supplements interact with Lovastatin?
In our interaction database, 184 supplement and herbal ingredients have an interaction with Lovastatin on file — 8 rated major, 140 moderate, and 36 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Apple, Grapefruit, Siberian Cocklebur.
Which Lovastatin supplement interactions are the most serious?
The 8 major-rated combinations — led by Apple, Grapefruit, Siberian Cocklebur, Sweet Orange and Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Lovastatin?
That depends entirely on which supplement. The honest answer for Lovastatin is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Mevacor have the same supplement interactions as Lovastatin?
Yes — Mevacor, Altocor all contain Lovastatin, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Lovastatin deplete any vitamins or nutrients?
It might — Lovastatin has 2 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Lovastatin nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Lovastatin and my other medications?
This page covers Lovastatin against supplements and herbal ingredients. Checking Lovastatin against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Lovastatin drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.