Drug & supplement interaction

Macadamia Nut + Simvastatin

Simvastatin brand name: Zocor.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Macadamia Nut and Simvastatin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Macadamia Nut and Simvastatin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Simvastatin and Macadamia Nut in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Macadamia Nut at all — not against Simvastatin, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Macadamia Nut safety at a glance

Macadamia Nut overall Generally safe Macadamia nuts are widely eaten as a food and are generally safe for people without nut allergies.
Pregnancy Likely Safe When used as food. Read the full pregnancy detail
Breastfeeding Likely Safe When used as food. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Simvastatin and Macadamia Nut? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Macadamia Nut and Simvastatin May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 2 of them are worth acting on rather than waiting out — marked below.

  • A severe allergic reaction / An allergic reaction Worth acting on Additional detail

    Macadamia Nut

    “Orally, macadamia nut is well tolerated.

    Serious Adverse Effects (Rare):

    All routes of administration: Allergic reactions, including anaphylaxis and contact dermatitis.”

    Macadamia Nut · Natural Medicines adverse-effect record, reported in dermatitis.

    “Orally, eating macadamia nuts or macadamia nut oil can cause allergic reactions, including anaphylaxis. Processing methods may affect the allergenicity of macadamia nuts.

    Topically, occupational exposure to macadamia nut shells has resulted in allergic contact dermatitis.”

    Macadamia Nut · Natural Medicines adverse-effect record, reported in dermatitis.

    6 sources cited
    1. 12600. Lerch M, Egger C, Bircher AJ. Allergic reactions to macadamia nut. Allergy 2005;60:130-1. PubMed
    2. 12601. Pallares DE. Allergy to macadamia nut. Ann Allergy Asthma Immunol 2000;85:385-6. PubMed
    3. 100019. De Knop KJ, Hagendorens MM, Bridts CH, Stevens WJ, Ebo DG. Macadamia nut allergy: 2 case reports and a review of the literature. Acta Clin Belg. 2010;65(2):129-32.
    4. 100031. Randhawa I, Morphew T, Marsteller NL. Correlation of negative skin-prick test results for tree nuts and successful tree nut challenges among children with peanut allergy. Allergy Asthma Proc. 2018;39(6):456-460. PubMed
    5. 100032. Polk BI, Dinakarpandian D, Nanda M, Barnes C, Dinakar C. Association of tree nut and coconut sensitizations. Ann Allergy Asthma Immunol. 2016;117(4):412-416. PubMed
    6. 100033. Ekbote A, Hayman G, Bansal A. Macadamia nut allergy: potentially misleading specific IgE results. Allergy. 2010;65(10):1345. PubMed

    Simvastatin

    Listed in the ADVERSE REACTIONS section of the FDA label for Simvastatin. Read the label on DailyMed ›

Reported for Macadamia Nut but not commonly for Simvastatin: a skin rash.

Effects for Simvastatin come from the ADVERSE REACTIONS section of its FDA label; effects for Macadamia Nut come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 261,345 voluntary FDA FAERS reports for Simvastatin that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Macadamia Nut in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used as food.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Simvastatin Is Prescribed For, and What Macadamia Nut Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Simvastatin is a prescription medicine with approved uses on its FDA label. Macadamia Nut is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Simvastatin is prescribed for: Simvastatin tablets are used alongside a cholesterol-lowering diet to treat high LDL cholesterol (bad cholesterol), high triglycerides, and certain inherited cholesterol disorders, including heterozygous familial hypercholesterolemia (HeFH) in adults and children aged 10 and older, and homozygous familial hypercholesterolemia (HoFH) in adults. In adults who already have coronary heart disease, cerebrovascular disease, peripheral vascular disease, or diabetes and are at high risk for heart events, simvastatin is also used to reduce the risk of death from heart disease, non-fatal heart attack, stroke, and the need for procedures to open blocked arteries. Zocor is one brand-name product containing simvastatin and carries these same indications.

Macadamia Nut has been studied for:

  • Hypercholesterolemia Natural Medicines rates the evidence for Macadamia Nut: Possibly Effective Read what the research shows

    Macadamia Nut for hypercholesterolemia

    Most research shows that consuming macadamia nuts as part of the diet can lower cholesterol levels.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Simvastatin on your own; if you are taking Macadamia Nut for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Macadamia Nut or Simvastatin

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Macadamia Nut or Simvastatin, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Simvastatin

This page covers Macadamia Nut only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Simvastatin page lists 183 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Apple (major), Beer (major), Grapefruit (major) and Siberian Cocklebur (major).

By severity: 8 major · 139 moderate · 36 minor.

Open the Simvastatin interaction page

How much people look this up

Where Macadamia Nut and Simvastatin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Macadamia Nut
Steady interest

#860 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Simvastatin
Top half

#1,082 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Macadamia Nut reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Macadamia Nut and Simvastatin records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Macadamia Nut

What is Macadamia Nut?

  • Heart health
  • Healthy snacking
  • Weight management
  • Skin and hair care (oil)
  • Source of healthy fats

Macadamia nuts are a nutritious food rich in healthy monounsaturated fats, fiber, and minerals, and they can be a part of a heart-healthy diet. They are mainly eaten as a food rather than used as a medicine, and the strongest evidence supports them as a wholesome snack rather than a treatment for any disease. People with tree nut allergies should avoid them.

Macadamia integrifolia · Proteaceae · Nut (seed kernel) and nut oil · Whole nuts, nut butter, nut oil, milk, flour

An interaction check asks whether these two react with each other — it does not ask whether Macadamia Nut is a good idea for someone in your situation. Here is what our Macadamia Nut record says about it on its own.

Macadamia Nut: dosing

There is no official medicinal dose for macadamia nuts because they are a food, not a standardized supplement. A common snack portion is a small handful of nuts.If you use a macadamia product such as oil, butter, or a supplement, follow the directions on the product label.

From our Macadamia Nut monograph — the full record covers uses, side effects and every documented interaction.

Read the full Macadamia Nut monograph & all interactions
Medication

About Simvastatin

What Is Simvastatin Used For?

Brand name: Zocor

Simvastatin tablets are used alongside a cholesterol-lowering diet to treat high LDL cholesterol (bad cholesterol), high triglycerides, and certain inherited cholesterol disorders, including heterozygous familial hypercholesterolemia (HeFH) in adults and children aged 10 and older, and homozygous familial hypercholesterolemia (HoFH) in adults.

In adults who already have coronary heart disease, cerebrovascular disease, peripheral vascular disease, or diabetes and are at high risk for heart events, simvastatin is also used to reduce the risk of death from heart disease, non-fatal heart attack, stroke, and the need for procedures to open blocked arteries. Zocor is one brand-name product containing simvastatin and carries these same indications.

Most-Reported Side Effects for Simvastatin

From FAERS, the FDA’s public side-effect reporting system (263,006 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 14,524 reports
Nausea 14,119 reports
Dyspnea 13,226 reports
Diarrhea 12,591 reports
Dizziness 11,830 reports
See full Simvastatin drug information
Keep checking

Other Drugs & Macadamia Nut

Browse every other medication we’ve checked against Macadamia Nut — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Macadamia Nut against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Macadamia Nut list.

See the full Macadamia Nut interactions page
See every supplement checked against Simvastatin, ranked by severity
Evidence & sources

Macadamia Nut References

The 11 references that drive our Macadamia Nut monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Garg ML, Blake RJ, Wills RB. Macadamia nut consumption lowers plasma total and LDL cholesterol levels in hypercholesterolemic men. J Nutr 2003;133:1060-3. PubMed
  2. Curb JD, Wergowske G, Dobbs JC, et al. Serum lipid effects of a high-monounsaturated fat diet based on macadamia nuts. Arch Intern Med 2000;160:1154-8. PubMed
  3. Lerch M, Egger C, Bircher AJ. Allergic reactions to macadamia nut. Allergy 2005;60:130-1. PubMed
  4. Pallares DE. Allergy to macadamia nut. Ann Allergy Asthma Immunol 2000;85:385-6. PubMed
  5. Teuber SS, Brown RL, Haapanen LA. Allergenicity of gourmet nut oils processed by different methods. J Allergy Clin Immunol 1997;99:502-7. PubMed
  6. Knight TE, Hausen BM. Dermatitis in a nutshell: occupational exposure to Macadamia integrifolia. J Am Acad Dermatol 1996;35:482-4. PubMed
  7. De Knop KJ, Hagendorens MM, Bridts CH, Stevens WJ, Ebo DG. Macadamia nut allergy: 2 case reports and a review of the literature. Acta Clin Belg. 2010;65(2):129-32.
  8. Randhawa I, Morphew T, Marsteller NL. Correlation of negative skin-prick test results for tree nuts and successful tree nut challenges among children with peanut allergy. Allergy Asthma Proc. 2018;39(6):456-460. PubMed
  9. Polk BI, Dinakarpandian D, Nanda M, Barnes C, Dinakar C. Association of tree nut and coconut sensitizations. Ann Allergy Asthma Immunol. 2016;117(4):412-416. PubMed
  10. Ekbote A, Hayman G, Bansal A. Macadamia nut allergy: potentially misleading specific IgE results. Allergy. 2010;65(10):1345. PubMed
  11. Herbst RA, Wahl R, Frosch PJ. Specific IgE reactivity and identification of potential allergens in macadamia allergy. J Eur Acad Dermatol Venereol. 2010;24(11):1361-3. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Macadamia Nut and Simvastatin Together: Common Questions

Is it safe to take Macadamia Nut with Simvastatin?
We do not list a known interaction between Macadamia Nut and Simvastatin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Macadamia Nut and Simvastatin have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Macadamia Nut and Simvastatin used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Macadamia Nut in each. That is a conversation for your prescriber, especially if Simvastatin is being adjusted to a target.
Does Simvastatin interact with any supplements?
Yes. Simvastatin has documented interactions with 183 supplements in our database — Macadamia Nut is not one of them. The Simvastatin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Macadamia Nut monograph Uses, safety profile, and every drug interaction in one place Simvastatin drug information The full plain-English guide to this medication Simvastatin supplement interactions Every supplement checked against Simvastatin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 11 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Simvastatin and Macadamia Nut?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.