Macadamia Nut Drug Interactions, Uses, Effectiveness, Safety & More
What is this page for?
First and foremost: how Macadamia Nut interacts with medications. The heart of this page is the interaction list — every drug Macadamia Nut is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Macadamia Nut is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Macadamia Nut against your medication
Add one medicationDrugs that interact with Macadamia Nut
0 medications have a known interaction with Macadamia Nut, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Macadamia Nut. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Macadamia Nut combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Macadamia Nut: Uses, Safety & Side Effects
Macadamia nuts are a nutritious food rich in healthy monounsaturated fats, fiber, and minerals, and they can be a part of a heart-healthy diet. They are mainly eaten as a food rather than used as a medicine, and the strongest evidence supports them as a wholesome snack rather than a treatment for any disease. People with tree nut allergies should avoid them.
- Scientific name
- Macadamia integrifolia
- Family
- Proteaceae
- Part used
- Nut (seed kernel) and nut oil
- Common forms
- Whole nuts, nut butter, nut oil, milk, flour
- Heart health
- Healthy snacking
- Weight management
- Skin and hair care (oil)
- Source of healthy fats
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Macadamia nuts are widely eaten as a food and are generally safe for people without nut allergies.
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
The macadamia nut is the edible seed of a tree native to Australia. It is now also grown in Hawaii, South Africa, and other warm regions. The nuts are known for their rich, buttery taste and high content of healthy fats.
Most people use macadamia nuts simply as a food. You can eat them whole, blended into nut butters and milks, ground into flour, or pressed into oil. The oil is also used in cooking and in skin and hair care products.
Although macadamia nuts are sometimes discussed for their possible health benefits, they are best thought of as a nutritious food rather than a medicine or supplement.
How it works
Macadamia nuts are rich in monounsaturated fatty acids, similar to the fats found in olive oil. These fats may help support a healthier blood lipid profile when they take the place of saturated or trans fats in the diet.
The nuts also provide fiber, plant compounds (such as antioxidants), and minerals like magnesium and manganese. These nutrients may contribute to overall health.
Much of the support for these effects comes from general nut research and laboratory studies. Direct, high-quality human studies on macadamia nuts alone are limited, so the exact health impact is not fully proven.
Does Macadamia Nut work?
How to read these evidence grades
Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.
Possibly Effective Hypercholesterolemia
Most research shows that consuming macadamia nuts as part of the diet can lower cholesterol levels.
Also studied for 1 condition — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Coronary heart disease (CHD)
It is unclear if consuming macadamia nuts as part of the diet can reduce the risk for CHD.
Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.
Safety & precautions
For most people, macadamia nuts are a safe food when eaten in normal amounts. The biggest concern is tree nut allergy. People allergic to tree nuts can have serious reactions, including life-threatening anaphylaxis, and should avoid macadamia nuts completely.
Because they are high in calories and fat, eating very large amounts can add up quickly, which may matter for people watching their weight or blood sugar. Whole nuts can also be a choking hazard for young children.
Eating macadamia nuts as a normal food is generally considered safe during pregnancy and breastfeeding for people who are not allergic. There is not enough research on concentrated macadamia supplements or extracts, so if you are pregnant or nursing, it is best to stick to food amounts and check with your doctor or pharmacist before using any supplement form.
Note for pet owners: Macadamia nuts are toxic to dogs and should be kept away from them.
Side effects
When eaten as a food, macadamia nuts usually cause few side effects in people who are not allergic. Eating a lot at once may cause stomach upset, bloating, or loose stools due to the fat and fiber.
The most serious risk is an allergic reaction in people sensitive to tree nuts. Signs can include hives, swelling, trouble breathing, or a drop in blood pressure. This is a medical emergency and requires immediate care.
Macadamia Nut: Reported Adverse Effects
Documented safety reports on Macadamia Nut from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
Orally, macadamia nut is well tolerated.
Serious Adverse Effects (Rare):
All routes of administration: Allergic reactions, including anaphylaxis and contact dermatitis.
Dermatitis Immunologic
Orally, eating macadamia nuts or macadamia nut oil can cause allergic reactions, including anaphylaxis. Processing methods may affect the allergenicity of macadamia nuts.
Topically, occupational exposure to macadamia nut shells has resulted in allergic contact dermatitis.
- Lerch M, Egger C, Bircher AJ. Allergic reactions to macadamia nut. Allergy 2005;60:130-1.
- Pallares DE. Allergy to macadamia nut. Ann Allergy Asthma Immunol 2000;85:385-6.
- De Knop KJ, Hagendorens MM, Bridts CH, Stevens WJ, Ebo DG. Macadamia nut allergy: 2 case reports and a review of the literature. Acta Clin Belg. 2010;65(2):129-32.
- Randhawa I, Morphew T, Marsteller NL. Correlation of negative skin-prick test results for tree nuts and successful tree nut challenges among children with peanut allergy. Allergy Asthma Proc. 2018;39(6):456-460.
- Polk BI, Dinakarpandian D, Nanda M, Barnes C, Dinakar C. Association of tree nut and coconut sensitizations. Ann Allergy Asthma Immunol. 2016;117(4):412-416.
- Ekbote A, Hayman G, Bansal A. Macadamia nut allergy: potentially misleading specific IgE results. Allergy. 2010;65(10):1345.
- Herbst RA, Wahl R, Frosch PJ. Specific IgE reactivity and identification of potential allergens in macadamia allergy. J Eur Acad Dermatol Venereol. 2010;24(11):1361-3.
- Teuber SS, Brown RL, Haapanen LA. Allergenicity of gourmet nut oils processed by different methods. J Allergy Clin Immunol 1997;99:502-7.
- Knight TE, Hausen BM. Dermatitis in a nutshell: occupational exposure to Macadamia integrifolia. J Am Acad Dermatol 1996;35:482-4.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no official medicinal dose for macadamia nuts because they are a food, not a standardized supplement. A common snack portion is a small handful of nuts.
If you use a macadamia product such as oil, butter, or a supplement, follow the directions on the product label. Because the nuts are calorie-dense, keep portions reasonable, especially if you are managing weight or blood sugar.
If you are unsure how macadamia nuts fit into your diet or health needs, check with your pharmacist or doctor.
Macadamia Nut & Pregnancy
Macadamia Nut & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 11 references that drive our Macadamia Nut monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Garg ML, Blake RJ, Wills RB. Macadamia nut consumption lowers plasma total and LDL cholesterol levels in hypercholesterolemic men. J Nutr 2003;133:1060-3. PubMed
- Curb JD, Wergowske G, Dobbs JC, et al. Serum lipid effects of a high-monounsaturated fat diet based on macadamia nuts. Arch Intern Med 2000;160:1154-8. PubMed
- Lerch M, Egger C, Bircher AJ. Allergic reactions to macadamia nut. Allergy 2005;60:130-1. PubMed
- Pallares DE. Allergy to macadamia nut. Ann Allergy Asthma Immunol 2000;85:385-6. PubMed
- Teuber SS, Brown RL, Haapanen LA. Allergenicity of gourmet nut oils processed by different methods. J Allergy Clin Immunol 1997;99:502-7. PubMed
- Knight TE, Hausen BM. Dermatitis in a nutshell: occupational exposure to Macadamia integrifolia. J Am Acad Dermatol 1996;35:482-4. PubMed
- De Knop KJ, Hagendorens MM, Bridts CH, Stevens WJ, Ebo DG. Macadamia nut allergy: 2 case reports and a review of the literature. Acta Clin Belg. 2010;65(2):129-32.
- Randhawa I, Morphew T, Marsteller NL. Correlation of negative skin-prick test results for tree nuts and successful tree nut challenges among children with peanut allergy. Allergy Asthma Proc. 2018;39(6):456-460. PubMed
- Polk BI, Dinakarpandian D, Nanda M, Barnes C, Dinakar C. Association of tree nut and coconut sensitizations. Ann Allergy Asthma Immunol. 2016;117(4):412-416. PubMed
- Ekbote A, Hayman G, Bansal A. Macadamia nut allergy: potentially misleading specific IgE results. Allergy. 2010;65(10):1345. PubMed
- Herbst RA, Wahl R, Frosch PJ. Specific IgE reactivity and identification of potential allergens in macadamia allergy. J Eur Acad Dermatol Venereol. 2010;24(11):1361-3. PubMed
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Macadamia Nut: Common Questions
What is Macadamia Nut used for, and does it work?
Does Macadamia Nut interact with prescription medications?
How are Macadamia Nut interactions rated?
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Where does this Macadamia Nut interaction information come from?
What are Macadamia Nuts good for?
Are Macadamia Nuts safe to eat every day?
Can I eat Macadamia Nuts while pregnant or breastfeeding?
Are Macadamia Nuts safe for dogs?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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