Simvastatin

168 interactions 138 explained in plain English 765 cited references

Also sold as: Flolipid Flolipid® Zocor Zocor®

About Simvastatin

Simvastatin is a statin that lowers cholesterol and triglycerides to reduce your risk of heart attack and stroke. Read the full Simvastatin drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Voriconazole Ritonavir Saquinavir Telaprevir Telithromycin Tipranavir

37 Contraindicated 99 Major 31 Moderate 1 Minor

All (168) Contraindicated (37) Major (99) Moderate (31) Minor (1)

Contraindicated

Simvastatin Amprenavir Explained An increased risk of myopathy or rhabdomyolysis Details Simvastatin Atazanavir Reyataz Explained An increased risk of simvastatin toxicity, including an increased risk of myopathy or rhabdomyolysis Details Simvastatin Boceprevir Explained Increased simvastatin concentrations and risk of myopathy and rhabdomyolysis Details Simvastatin Ceritinib Zykadia Explained Increased simvastatin exposure and an increased the risk of myopathy and rhabdomyolysis Details Simvastatin Clarithromycin Biaxin Explained An increased risk of myopathy or rhabdomyolysis Details Simvastatin Cobicistat Tybost Explained Increased simvastatin exposure and an increased risk of simvastatin toxicity, including an increased risk of myopathy or rhabdomyo... Details Simvastatin Cyclosporine Atopica Explained An increased risk of myopathy or rhabdomyolysis Details Simvastatin Danazol Danocrine® An increased risk of myopathy or rhabdomyolysis Details Simvastatin Darunavir Explained Increased simvastatin exposure; increased risk of myopathy or rhabdomyolysis Details Simvastatin Ensitrelvir Explained Increased simvastatin exposure and an increased risk of simvastatin-related adverse events Details Simvastatin Erythromycin Erythrocin Stearate Explained Increased simvastatin exposure, an increased risk of simvastatin-related adverse reaction and an increased risk of myopathy or rha... Details Simvastatin Fosamprenavir Lexiva Explained An increased risk of myopathy or rhabdomyolysis Details Simvastatin Gemfibrozil Lopid Increased exposure of simvastatin acid (active metabolite) and an increased risk of myopathy or rhabdomyolysis Details Simvastatin Idelalisib Zydelig Explained Increased simvastatin concentrations and risk of myopathy and rhabdomyolysis Details Simvastatin Indinavir Explained Increased simvastatin exposure and an increased risk of myopathy or rhabdomyolysis Details Simvastatin Itraconazole Sporanox Explained Increased simvastatin exposure and an increased risk of myopathy and rhabdomyolysis Details Simvastatin Ketoconazole Extina Explained Increased simvastatin exposure and an increased risk of myopathy or rhabdomyolysis Details Simvastatin Levoketoconazole Recorlev Explained Increased CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related adverse reaction Details Simvastatin Lonafarnib Zokinvy Explained Increased simvastatin exposure and an increased risk of myopathy or rhabdomyolysis Details Simvastatin Lopinavir Explained An increased risk of myopathy or rhabdomyolysis Details Simvastatin Mibefradil Explained An increased risk of myopathy and/or rhabdomyolysis Details Simvastatin Mifepristone Korlym Explained Increased simvastatin exposure and an increased risk of myopathy and rhabdomyolysis Details Simvastatin Nefazodone Explained An increased risk of myopathy or rhabdomyolysis Details Simvastatin Nelfinavir Viracept Explained An increased risk of myopathy or rhabdomyolysis Details Simvastatin Nirmatrelvir Explained Increased risk of myopathy or rhabdomyolysis Details Simvastatin Paritaprevir Explained Increased risk of myopathy, including rhabdomyolysis Details Simvastatin Posaconazole Noxafil Explained Increased simvastatin exposure and an increased risk of myopathy or rhabdomyolysis Details Simvastatin Ribociclib Kisqali Explained Increased simvastatin exposure and an increased the risk of myopathy and rhabdomyolysis Details Simvastatin Ritonavir Norvir Explained Increased simvastatin exposure and an increased risk of myopathy or rhabdomyolysis Details Simvastatin Saquinavir Explained Increased risk of myopathy or rhabdomyolysis Details Simvastatin Telaprevir Explained Increased simvastatin concentrations Details Simvastatin Telithromycin Explained Increased risk of myopathy or rhabdomyolysis Details Simvastatin Tipranavir Aptivus Explained An increased risk of myopathy or rhabdomyolysis Details Simvastatin Voriconazole Vfend Explained Increased simvastatin exposure, an increased risk of simvastatin adverse effects an increased risk of rhabdomyolysis, increased vo... Details Simvastatin Cyclosporine Injection Atopica An increased risk of myopathy or rhabdomyolysis Details Simvastatin Cyclosporine Ophthalmic Cequa An increased risk of myopathy or rhabdomyolysis Details Simvastatin Ketoconazole Topical Extina® Foam Increased simvastatin exposure and an increased risk of myopathy or rhabdomyolysis Details

Major

Simvastatin Colchicine Colcrys Explained An increased risk of myopathy or rhabdomyolysis Details Simvastatin Acenocoumarol Explained An increased risk of bleeding and increased risk of rhabdomyolysis Details Simvastatin Adagrasib Krazati Explained Increased CYP3A4 substrate exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.