Drug & supplement interaction

Thiamine + Simvastatin

Simvastatin brand name: Zocor.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Thiamine and Simvastatin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Thiamine and Simvastatin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Simvastatin and Thiamine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Thiamine safety at a glance

Thiamine overall Generally safe Thiamine is generally very safe when taken by mouth in normal amounts.
Pregnancy Likely Safe When used orally in dietary amounts of 1.4 mg daily. A tolerable upper intake level (UL) has not been established for healthy individuals. Read the full pregnancy detail
Breastfeeding Likely Safe When used orally in dietary amounts of 1.4 mg daily. A tolerable upper intake level (UL) has not been established for healthy individuals. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Simvastatin and Thiamine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Simvastatin

Interactions in our licensed database are recorded against drug classes, not just single drug names. Simvastatin is filed under 8 classifications — including hmg-coa reductase inhibitors ("statins"), organic anion-transporting polypeptide substrates (oatp), glucuronidated drugs. Thiamine has documented interactions with 1 drug class — the most serious being trimethoprim (proloprim) (minor) — and none of Simvastatin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Thiamine Does Interact With Other Medications

Thiamine has 3 minor known drug interactions in our database — Simvastatin isn’t one of them. If you take anything else, check it against the full list below.

Minor 3 No known interaction 2,827 (incl. Simvastatin)
Taking anything else?

Check Another of Your Medications Against Thiamine

Covers the 2,830 medications we’ve checked against Thiamine. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Thiamine and Simvastatin May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 5 of them are worth acting on rather than waiting out — marked below.

  • Shortness of breath / A severe allergic reaction / Hives / Bleeding or bruising / An allergic reaction Worth acting on reported in 5.0% of FDA reports for Simvastatin Additional detail

    Thiamine

    “Orally, thiamine might rarely cause dermatitis and other allergic reactions. Parenterally, thiamine can cause anaphylactoid and hypersensitivity reactions, but this is also rare (”

    Thiamine · Natural Medicines adverse-effect record, reported in acute respiratory distress syndrome (ards).

    4 sources cited
    1. 15. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
    2. 35585. Rogovik, A. L., Vohra, S., and Goldman, R. D. Safety considerations and potential interactions of vitamins: should vitamins be considered drugs? Ann.Pharmacother. 2010;44(2):311-324. PubMed
    3. 105445. Thiamine hydrochloride injection package insert. Lake Zurich, IL: Fresenius Kabi, LLC; September 2019.
    4. 91170. Arruti N, Bernedo N, Audicana MT, Villarreal O, Uriel O, Muñoz D. Systemic allergic dermatitis caused by thiamine after iontophoresis. Contact Dermatitis. 2013 Dec;69(6):375-6. PubMed

    Simvastatin

    Listed in the ADVERSE REACTIONS section of the FDA label for Simvastatin, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Numbness or tingling / Itching / Swelling Additional detail

    Thiamine

    Recorded for Thiamine in the same Natural Medicines adverse-effect record shown under Shortness of breath / A severe allergic reaction / Hives / Bleeding or bruising / An allergic reaction above.

    Simvastatin

    Listed in the ADVERSE REACTIONS section of the FDA label for Simvastatin. Read the label on DailyMed ›

Reported for Thiamine but not commonly for Simvastatin: bleeding in the gut, low blood pressure and a skin rash.

Effects for Simvastatin come from the ADVERSE REACTIONS section of its FDA label; effects for Thiamine come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 261,345 voluntary FDA FAERS reports for Simvastatin that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Thiamine in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used orally in dietary amounts of 1.4 mg daily. A tolerable upper intake level (UL) has not been established for healthy individuals.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Simvastatin Is Prescribed For, and What Thiamine Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Simvastatin is a prescription medicine with approved uses on its FDA label. Thiamine is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Simvastatin is prescribed for: Simvastatin tablets are used alongside a cholesterol-lowering diet to treat high LDL cholesterol (bad cholesterol), high triglycerides, and certain inherited cholesterol disorders, including heterozygous familial hypercholesterolemia (HeFH) in adults and children aged 10 and older, and homozygous familial hypercholesterolemia (HoFH) in adults. In adults who already have coronary heart disease, cerebrovascular disease, peripheral vascular disease, or diabetes and are at high risk for heart events, simvastatin is also used to reduce the risk of death from heart disease, non-fatal heart attack, stroke, and the need for procedures to open blocked arteries. Zocor is one brand-name product containing simvastatin and carries these same indications.

Thiamine has been studied for:

  • Diabetes studied, not established Thiamine has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Thiamine for diabetes

    It is unclear if oral thiamine is beneficial for type 2 diabetes or gestational diabetes.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Simvastatin on your own; if you are taking Thiamine for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Thiamine or Simvastatin

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Thiamine or Simvastatin, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Simvastatin

This page covers Thiamine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Simvastatin page lists 183 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Apple (major), Beer (major), Grapefruit (major) and Siberian Cocklebur (major).

By severity: 8 major · 139 moderate · 36 minor.

Open the Simvastatin interaction page

One more smart check

Taking Thiamine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 3 real supplement products containing Thiamine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Thiamine. Even though Thiamine itself has no known interaction with Simvastatin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Thiamine and Simvastatin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Thiamine
Top 25%

#174 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Simvastatin
Top half

#1,082 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Thiamine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Thiamine and Simvastatin records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Thiamine

What is Thiamine?

  • Preventing or treating thiamine deficiency
  • Beriberi
  • Wernicke-Korsakoff syndrome (alcohol-related)
  • Supporting energy and nerve function
  • General B-vitamin supplementation

Thiamine (vitamin B1) is an essential nutrient your body needs to turn food into energy and to keep your nerves and heart healthy. Most people get enough from food, but supplements are clearly useful for deficiency, certain medical conditions, and people with heavy alcohol use. Talk with your pharmacist or doctor before starting it, especially if you have a chronic illness.

Tablets, capsules, oral liquids, injectable solutions (prescription), part of B-complex and multivitamins

An interaction check asks whether these two react with each other — it does not ask whether Thiamine is a good idea for someone in your situation. Here is what our Thiamine record says about it on its own.

Thiamine: dosing

The right dose of thiamine depends on your age, health, and the reason you are taking it. There is a recommended daily intake for general nutrition, and higher amounts are sometimes used by doctors to treat a deficiency.For supplements, the best approach is to follow the directions on the product label and not exceed them without guidance.

From our Thiamine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Thiamine monograph & all interactions
Medication

About Simvastatin

What Is Simvastatin Used For?

Brand name: Zocor

Simvastatin tablets are used alongside a cholesterol-lowering diet to treat high LDL cholesterol (bad cholesterol), high triglycerides, and certain inherited cholesterol disorders, including heterozygous familial hypercholesterolemia (HeFH) in adults and children aged 10 and older, and homozygous familial hypercholesterolemia (HoFH) in adults.

In adults who already have coronary heart disease, cerebrovascular disease, peripheral vascular disease, or diabetes and are at high risk for heart events, simvastatin is also used to reduce the risk of death from heart disease, non-fatal heart attack, stroke, and the need for procedures to open blocked arteries. Zocor is one brand-name product containing simvastatin and carries these same indications.

Most-Reported Side Effects for Simvastatin

From FAERS, the FDA’s public side-effect reporting system (263,006 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 14,524 reports
Nausea 14,119 reports
Dyspnea 13,226 reports
Diarrhea 12,591 reports
Dizziness 11,830 reports
See full Simvastatin drug information
Keep checking

Other Drugs & Thiamine

Browse every other medication we’ve checked against Thiamine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
3Minor
2,826No known interaction
3 Minor 2,826 No interaction
Minor

3 interactions

No interaction 2,826 drugs checked — show the list

We also checked Thiamine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,826 medications checked with no known interaction — see the full Thiamine list.

See the full Thiamine interactions page
See every supplement checked against Simvastatin, ranked by severity
Evidence & sources

Thiamine References

The 7 references that drive our Thiamine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  4. Rogovik, A. L., Vohra, S., and Goldman, R. D. Safety considerations and potential interactions of vitamins: should vitamins be considered drugs? Ann.Pharmacother. 2010;44(2):311-324. PubMed
  5. Arruti N, Bernedo N, Audicana MT, Villarreal O, Uriel O, Muñoz D. Systemic allergic dermatitis caused by thiamine after iontophoresis. Contact Dermatitis. 2013 Dec;69(6):375-6. PubMed
  6. Thiamine hydrochloride injection package insert. Lake Zurich, IL: Fresenius Kabi, LLC; September 2019.
  7. Vora B, Wen A, Yee SW, et al. The Effect of Trimethoprim on Thiamine Absorption: A Transporter-Mediated Drug-Nutrient Interaction. Clin Pharmacol Ther 2023;114(2):381-392.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Thiamine and Simvastatin Together: Common Questions

Is it safe to take Thiamine with Simvastatin?
We do not list a known interaction between Thiamine and Simvastatin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Thiamine and Simvastatin have any of the same side effects?
Yes — our sources link each of them separately to 8 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Thiamine and Simvastatin used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Thiamine in each. That is a conversation for your prescriber, especially if Simvastatin is being adjusted to a target.
How was the Thiamine and Simvastatin combination checked?
Interactions in our licensed database are recorded against drug classes. Simvastatin is filed under 8 classifications, and Thiamine has documented interactions with 1 drug class — none of Simvastatin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Thiamine interact with any other medications?
Yes. Thiamine has 3 documented drug interactions in our database — Simvastatin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Simvastatin interact with any supplements?
Yes. Simvastatin has documented interactions with 183 supplements in our database — Thiamine is not one of them. The Simvastatin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Thiamine monograph Uses, safety profile, and every drug interaction in one place Simvastatin drug information The full plain-English guide to this medication Simvastatin supplement interactions Every supplement checked against Simvastatin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Simvastatin and Thiamine?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.