Medication interaction hub

What Supplements Interact with Pitavastatin?

Pitavastatin brand names: Zypitamag, Nikita. Every interaction below applies to the brands too.

126 Interactions 5 Major 98 Moderate 23 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Pitavastatin? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Pitavastatin against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Liver strain runs through the serious end of pitavastatin's (Zypitamag, Nikita) supplement interactions, and this list deserves real care rather than a quick skim. The biggest cluster of worrisome entries is herbs and ingredients with their own record of liver injury, and alcohol belongs to that group too, with beer and wine both carrying major ratings for the added liver risk. Grapefruit is the other headline, rated major because it can raise statin blood levels enough to increase side effects.

A few interactions work differently. Red yeast rice naturally contains a statin, so stacking it on pitavastatin can amount to an accidental double dose. Charcoal-type products can soak up the drug in the gut and weaken it, so space them well apart from your dose. The rest is mostly a shared liver enzyme pathway, milder territory. Of 126 entries in all, 5 rate major, 98 moderate, and 23 minor, and those five majors are the place to start reading.

— , Clinical Pharmacist · July 18, 2026

Major 5 Moderate 98 Minor 23 No known interaction 1,326

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Pitavastatin: Top Interactions at a Glance

The most significant Pitavastatin supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 126 interacting ingredients — plus 1,326 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Pitavastatin + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Grapefruit + Pitavastatini

Grapefruit juice can increase blood levels of statins that are metabolized by cytochrome P450 3A4 (CYP3A4), potentially increasing the effects and adverse effec...

Read the full interaction Major Likelihood Likely Siberian Cocklebur + Pitavastatini

Siberian cocklebur can adversely affect the liver.

Read the full interaction Major Likelihood Probable Activated Charcoal + Pitavastatini

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Beer + Pitavastatini

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction Major Likelihood Probable Wine + Pitavastatini

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction
The complete list

Every Supplement Checked Against Pitavastatin

All 1,452 ingredients in our database, ranked by severity — 126 with a Pitavastatin interaction on file and 1,326 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Pitavastatin?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Green Tea with Pitavastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive adverse hepatotoxic effects.

Full Green Tea + Pitavastatin answer

Can you take Cabbage with Pitavastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cabbage might increase clearance and decrease the effects of drugs metabolized through glucuronide conjugation.

Full Cabbage + Pitavastatin answer

Can you take Ephedra with Pitavastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive adverse hepatotoxic effects.

Full Ephedra + Pitavastatin answer

Can you take Epistane with Pitavastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive adverse hepatotoxic effects.

Full Epistane + Pitavastatin answer

Can you take Eucalyptus with Pitavastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eucalyptus might increase the levels of CYP2C9 substrates.

Full Eucalyptus + Pitavastatin answer

Can you take Feverfew with Pitavastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, feverfew might increase levels of drugs metabolized by CYP2C9.

Full Feverfew + Pitavastatin answer

Can you take Fo-ti with Pitavastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fo-ti might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Fo-ti + Pitavastatin answer

Can you take Garcinia with Pitavastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.

Full Garcinia + Pitavastatin answer

Can you take German Chamomile with Pitavastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, German chamomile might inhibit CYP2C9 and increase levels of drugs metabolized by these enzymes.

Full German Chamomile + Pitavastatin answer

Can you take Ginkgo with Pitavastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ginkgo might increase levels of drugs metabolized by CYP2C9.

Full Ginkgo + Pitavastatin answer

Can you take Goji with Pitavastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, goji berry might inhibit CYP2C9 and reduce metabolism of CYP2C9 substrates.

Full Goji + Pitavastatin answer

Can you take Goldenseal with Pitavastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, goldenseal might increase serum levels of drugs metabolized by CYP2C9.

Full Goldenseal + Pitavastatin answer

Can you take Gotu Kola with Pitavastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking gotu kola with hepatotoxic drugs might have additive adverse effects.

Full Gotu Kola + Pitavastatin answer

Can you take Greater Celandine with Pitavastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There is some concern that greater celandine can adversely affect the liver.

Full Greater Celandine + Pitavastatin answer

Can you take Guar Gum with Pitavastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Full Guar Gum + Pitavastatin answer

Can you take Gum Arabic with Pitavastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Pitavastatin answer

Can you take Gymnema with Pitavastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gymnema might increase or decrease levels of drugs metabolized by CYP2C9.

Full Gymnema + Pitavastatin answer

Can you take Hemp Agrimony with Pitavastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Hemp agrimony contains hepatotoxic pyrrolizidine alkaloids (PA).

Full Hemp Agrimony + Pitavastatin answer

Can you take Inositol Nicotinate with Pitavastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of inositol nicotinate and statins might increase the risk of myopathy and rhabdomyolysis.

Full Inositol Nicotinate + Pitavastatin answer

Can you take Ipriflavone with Pitavastatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Ipriflavone is thought to competitively inhibit cytochrome P450 2C9 (CYP2C9).

Full Ipriflavone + Pitavastatin answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Pitavastatin is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Pitavastatin, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Pitavastatin sits in 6 interaction categories. Open any one to see what the group means:

Cytochrome P450 2C9 (Cyp2C9) Substrates 64 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

64 of the supplement ingredients on this page reach Pitavastatin through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Pitavastatin through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Pitavastatin through this category.

Glucuronidated Drugs 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Pitavastatin through this category.

Hmg-Coa Reductase Inhibitors ("Statins") 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Pitavastatin through this category.

Pitavastatin (Livalo) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Pitavastatin through this category.

About Pitavastatin

Pitavastatin is a statin (cholesterol-lowering) tablet used to reduce LDL-C (bad cholesterol) in adults with high cholesterol and, for certain products, in children aged 8 and older with an inherited cholesterol condition.

Generic name: Pitavastatin  ·  Brand names: Zypitamag, Nikita.

See the full Pitavastatin drug information

Related: does Pitavastatin deplete any nutrients?

Pitavastatin has 2 reported nutrient associations in the research literature — see the Pitavastatin nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Pitavastatin

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Pitavastatin.

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Pharmacist Counseling Corner

Pitavastatin & Supplements: Common Questions

What supplements interact with Pitavastatin?
In our interaction database, 126 supplement and herbal ingredients have an interaction with Pitavastatin on file — 5 rated major, 98 moderate, and 23 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Grapefruit, Siberian Cocklebur, Activated Charcoal.
Which Pitavastatin supplement interactions are the most serious?
Focus on the major group: Grapefruit, Siberian Cocklebur, Activated Charcoal, Beer and Wine. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Pitavastatin?
That depends entirely on which supplement. The honest answer for Pitavastatin is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Zypitamag have the same supplement interactions as Pitavastatin?
Yes — Zypitamag, Nikita all contain Pitavastatin, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Pitavastatin deplete any vitamins or nutrients?
It might — Pitavastatin has 2 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Pitavastatin nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Pitavastatin and my other medications?
This page covers Pitavastatin against supplements and herbal ingredients. Checking Pitavastatin against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Pitavastatin drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.