Lomitapide

Generic name: Pronounced as loe mi' ta pide)
Brand names
  • Juxtapid®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 02/15/2017

Lomitapide may cause serious damage to the liver. Tell your doctor if you have or have ever had liver disease or if you have ever had liver problems while taking other medications. Your doctor may tell you not to take lomitapide. Tell your doctor if you drink alcohol. Drinking alcohol may increase the risk that you will develop liver problems. Do not drink more than one alcoholic beverage per day while you are taking lomitapide. Tell your doctor and pharmacist if you are taking acetaminophen (Tylenol, others), amiodarone (Cordarone), doxycycline (Doryx, Vibramycin, others), isotretinoin (Accutane), methotrexate (Rheumatrex), minocycline (Dynacin, Minocin), tamoxifen (Nolvadex), or tetracycline (Sumycin). If you experience any of the following symptoms at any time during your treatment, stop taking lomitapide and call your doctor immediately: extreme tiredness, lack of energy, weakness, nausea or vomiting that gets worse or does not go away, pain in the upper right part of the stomach, loss of appetite, yellowing of the skin or eyes, fever, or flu-like symptoms. Your doctor may need to change the dose or stop or delay your treatment if you experience liver problems.

A program called Juxtapid REMS® has been approved by the Food and Drug Administration (FDA) because of the possibility of liver damage associated with lomitapide use. All people who are prescribed lomitapide must have a lomitapide prescription from a doctor who is registered with Juxtapid REMS®, and have the prescription filled at a pharmacy that is registered with Juxtapid REMS® in order to receive this medication.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests before and during your treatment to check your body's response to lomitapide.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with lomitapide and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide.

Lomitapide is used along with diet changes (restriction of cholesterol and fat intake) and other treatments to reduce the amount of low-density lipoprotein (LDL) cholesterol ('bad cholesterol'), total cholesterol, and other fatty substances in the blood in people that have homozygous familial hypercholesterolemia (HoFH; an inherited condition in which cholesterol cannot be removed from the body normally). Lomitapide should not be used to decrease cholesterol levels in people who do not have HoFH. Lomitapide is in a class of medications called cholesterol-lowering medications. It works by slowing the production of cholesterol in the body to decrease the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body.

Accumulation of cholesterol and fats along the walls of your arteries (a process known as atherosclerosis) decreases blood flow and, therefore, the oxygen supply to your heart, brain, and other parts of your body. Lowering your blood level of cholesterol and fats may help prevent heart disease, angina (chest pain), strokes, and heart attacks.

Lomitapide comes as a capsule to take by mouth. It is usually taken once a day. Lomitapide should be taken without food on an empty stomach, at least 2 hours after your evening meal. Drink a full glass of water with each dose of lomitapide.

Take lomitapide at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take lomitapide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the capsules whole; do not split, chew, dissolve, or crush them.

You will need to take a vitamin supplement during your treatment with lomitapide Be sure to follow the recommendations made by your doctor carefully.

Continue to take lomitapide even if you feel well. Do not stop taking lomitapide without talking to your doctor.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking lomitapide,

  • tell your doctor and pharmacist if you are allergic to lomitapide, any other medications, or any of the ingredients in lomitapide capsules. Ask your pharmacist or check the Medication Guide for a list of the ingredients.

  • tell your doctor if you are taking antifungal medications such as fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), and voriconazole (Vfend); boceprevir (Victrelis); aprepitant (Emend); ciprofloxacin (Cipro); clarithromycin (Biaxin); crizotinib (Xalkori); diltiazem (Cardizem, Dilacor, Tiazac); erythromycin (E.E.S., E-Mycin, Erythrocin); HIV protease inhibitors such as amprenavir (Agenerase), atazanavir (Reyataz), darunavir (Prezista), fosamprenavir (Lexiva), indinavir (Crixivan), lopinavir (in Kaletra), nelfinavir (Viracept), saquinavir (Invirase), ritonavir (Norvir, in Kaletra), ritonavir and tipranavir (Aptivus), and teleprevir (Incivek); imatinib (Gleevec); nefazodone; telithromycin (Ketek); and verapamil (Calan, Covera, Isoptin, Verelan). Your doctor will probably tell you not to take lomitapide if you are taking one or more of these medications.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: aliskiren (Tekturna); alprazolam (Xanax); ambrisentan (Letairis); amiodarone (Cordarone, Pacerone); amlodipine (Norvasc, in Caduet); bicalutamide (Casodex); cilostazol (Pletal); certain oral medications for diabetes such as saxagliptin (Onglyza in Kombiglyze) and sitagliptin (Januvia, in Janumet); cimetidine (Tagament); colchicine (Colcrys); dabigatran (Pradaxa); digoxin (Lanoxin); everolimus (Afinitor, Zortress); fexofenadine (Allegra); fluoxetine (Prozac); fluvoxamine (Luvox); isoniazid (INH, Nydrazid); lapatinib (Tykerb); maraviroc (Selzentry); medications that suppress the immune system such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune) and tacrolimus (Prograf); nilotinib (Tasigna); oral contraceptives (birth control pills); other cholesterol lowering medications such as atorvastatin (Lipitor, in Caduet, in Liptruzet), lovastatin (Mevacor), and simvastatin (Zocor, in Simcor, in Vytorin); pazopanib (Votrient); ranitidine (Zantac); ranolazine (Ranexa); ticagrelor (Brilinta); tolvaptan (Samsca); topotecan (Hycamtin); warfarin (Coumadin); and zileuton (Zyflo). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with lomitapide, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

  • tell your doctor what herbal products you are taking, especially ginkgo or goldenseal.

  • if you are taking cholestyramine (Questran), colesevelam (WellChol), or colestipol (Colestid), take it 4 hours before or 4 hours after lomitapide.

  • tell your doctor if you have or have ever had galactose intolerance or glucose-galactose malabsorption (inherited conditions where the body is not able to tolerate lactose), ongoing stomach or intestinal problems, or pancreas or kidney disease.

  • Tell your doctor if you are pregnant or plan to become pregnant. If you are female who can become pregnant, you will need to take a pregnancy test before you begin taking lomitapide. If you can become pregnant, you should use effective birth control while taking lomitapide. Talk to your doctor about birth control methods that will work for you. If you become pregnant while taking lomitapide, stop taking the medication and call your doctor immediately. Lomitapide can harm the fetus.

  • tell your doctor if you are breast-feeding. You should not breast-feed while you are taking lomitapide.

Do not eat grapefruit or drink grapefruit juice while taking this medication.

Your doctor will tell you to eat a low-fat diet. Eating a low-fat diet may lower the chance that you will have stomach problems including nausea, vomiting, upset stomach, and diarrhea while you are taking lomitapide. Follow all dietary recommendations made by your doctor or dietitian carefully.

Skip the missed dose and continue your regular dosing schedule the next day. Do not take a double dose to make up for a missed one.

  • Lomitapide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • diarrhea

    • nausea

    • vomiting

    • stomach pain

    • constipation

    • bloating

    • gas

    • upset stomach

    • weight loss

    • headache

    • dizziness

    • sore throat

    • runny nose

    • back pain

  • Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, stop taking lomitapide and call your doctor immediately or get emergency medical treatment:

    • severe diarrhea

    • lightheadedness

    • decreased urine output

  • Lomitapide may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Delavirdine Delavirdine The metabolism of Lomitapide can be decreased when combined with Delavirdine.
Atorvastatin Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Lomitapide.
Aminophylline Aminophylline The metabolism of Lomitapide can be decreased when combined with Aminophylline.
Cilostazol Cilostazol The metabolism of Cilostazol can be decreased when combined with Lomitapide.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The metabolism of Lomitapide can be decreased when combined with Erythromycin.
Fenofibrate Fenofibrate The metabolism of Fenofibrate can be decreased when combined with Lomitapide.
Methylergonovine Methylergonovine The metabolism of Lomitapide can be decreased when combined with Methylergometrine.
Paregoric Paregoric The serum concentration of Lomitapide can be increased when it is combined with Morphine.
Tacrolimus Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Lomitapide.
Triamcinolone Triamcinolone The metabolism of Lomitapide can be increased when combined with Triamcinolone.
Doxycycline Injection Doxycycline Injection The metabolism of Lomitapide can be decreased when combined with Doxycycline.
Fluconazole Injection Fluconazole Injection The metabolism of Lomitapide can be decreased when combined with Fluconazole.
Meperidine Injection Meperidine Injection The metabolism of Lomitapide can be increased when combined with Meperidine.
Methylprednisolone Injection Methylprednisolone Injection The metabolism of Lomitapide can be increased when combined with Methylprednisolone.
Metronidazole Injection Metronidazole Injection The metabolism of Lomitapide can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection The serum concentration of Lomitapide can be increased when it is combined with Morphine.
Cyclosporine Cyclosporine The serum concentration of Lomitapide can be increased when it is combined with Cyclosporine.
Dofetilide Dofetilide The metabolism of Lomitapide can be decreased when combined with Dofetilide.
Orlistat Orlistat The metabolism of Lomitapide can be increased when combined with Orlistat.
Oxcarbazepine Oxcarbazepine The metabolism of Lomitapide can be increased when combined with Oxcarbazepine.
Sevelamer Sevelamer Sevelamer can cause a decrease in the absorption of Lomitapide resulting in a reduced serum concentration and potentially a decrease in efficacy.
Anakinra Anakinra The metabolism of Lomitapide can be increased when combined with Anakinra.
Trimipramine Trimipramine The serum concentration of Trimipramine can be increased when it is combined with Lomitapide.
Etanercept Injection Etanercept Injection The metabolism of Lomitapide can be increased when combined with Etanercept.
Modafinil Modafinil The metabolism of Lomitapide can be increased when combined with Modafinil.
Tenofovir Tenofovir The metabolism of Tenofovir can be decreased when combined with Lomitapide.
Sirolimus Sirolimus The serum concentration of Sirolimus can be increased when it is combined with Lomitapide.
Epinephrine Injection Epinephrine Injection The metabolism of Lomitapide can be decreased when combined with Epinephrine.
Adalimumab Injection Adalimumab Injection The metabolism of Lomitapide can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Lomitapide.
Atazanavir Atazanavir The metabolism of Lomitapide can be decreased when combined with Atazanavir.
Mefloquine Mefloquine The metabolism of Lomitapide can be decreased when combined with Mefloquine.
Rosuvastatin Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Lomitapide.
Vardenafil Vardenafil The metabolism of Vardenafil can be decreased when combined with Lomitapide.
Alfuzosin Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Lomitapide.
Aprepitant Aprepitant The metabolism of Lomitapide can be decreased when combined with Aprepitant.
Tegaserod Tegaserod The serum concentration of Tegaserod can be increased when it is combined with Lomitapide.
Progesterone Progesterone The metabolism of Lomitapide can be increased when combined with Progesterone.
Infliximab Injection Infliximab Injection The metabolism of Lomitapide can be increased when combined with Infliximab.
Rifaximin Rifaximin The serum concentration of Rifaximin can be increased when it is combined with Lomitapide.
Duloxetine Duloxetine The metabolism of Lomitapide can be decreased when combined with Duloxetine.
Norethindrone Norethindrone The metabolism of Norethisterone can be decreased when combined with Lomitapide.
Bosentan Bosentan The metabolism of Lomitapide can be increased when combined with Bosentan.
Erlotinib Erlotinib The metabolism of Lomitapide can be decreased when combined with Erlotinib.
Eszopiclone Eszopiclone The metabolism of Eszopiclone can be decreased when combined with Lomitapide.
Voriconazole Voriconazole The metabolism of Lomitapide can be decreased when combined with Voriconazole.
Fentanyl Fentanyl The metabolism of Fentanyl can be decreased when combined with Lomitapide.
Deferasirox Deferasirox The metabolism of Lomitapide can be increased when combined with Deferasirox.
Tipranavir Tipranavir The metabolism of Tipranavir can be decreased when combined with Lomitapide.
Felbamate Felbamate The metabolism of Lomitapide can be increased when combined with Felbamate.
Ranolazine Ranolazine The metabolism of Ranolazine can be decreased when combined with Lomitapide.
Abatacept Injection Abatacept Injection The metabolism of Lomitapide can be increased when combined with Abatacept.
Imatinib Imatinib The metabolism of Lomitapide can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin The serum concentration of Lomitapide can be increased when it is combined with Sitagliptin.
Gefitinib Gefitinib The metabolism of Lomitapide can be decreased when combined with Gefitinib.
Paliperidone Paliperidone The serum concentration of Lomitapide can be increased when it is combined with Paliperidone.
Bortezomib Bortezomib The metabolism of Bortezomib can be decreased when combined with Lomitapide.
Posaconazole Posaconazole The metabolism of Posaconazole can be decreased when combined with Lomitapide.
Primaquine Primaquine The metabolism of Lomitapide can be decreased when combined with Primaquine.
Darunavir Darunavir The serum concentration of Lomitapide can be increased when it is combined with Darunavir.
Retapamulin Retapamulin The metabolism of Retapamulin can be decreased when combined with Lomitapide.
Sorafenib Sorafenib The metabolism of Lomitapide can be decreased when combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Lomitapide can be decreased when combined with Sunitinib.
Lapatinib Lapatinib The metabolism of Lomitapide can be decreased when combined with Lapatinib.
Dasatinib Dasatinib The metabolism of Lomitapide can be decreased when combined with Dasatinib.
Armodafinil Armodafinil The metabolism of Lomitapide can be increased when combined with Armodafinil.
Ivermectin Ivermectin The metabolism of Lomitapide can be increased when combined with Ivermectin.
Temsirolimus Temsirolimus The serum concentration of Temsirolimus can be increased when it is combined with Lomitapide.
Nilotinib Nilotinib The metabolism of Lomitapide can be decreased when combined with Nilotinib.
Toremifene Toremifene The serum concentration of Lomitapide can be increased when it is combined with Toremifene.
Bexarotene Bexarotene The metabolism of Lomitapide can be increased when combined with Bexarotene.
Budesonide Budesonide The metabolism of Lomitapide can be increased when combined with Budesonide.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Lomitapide can be decreased when combined with Chloramphenicol.
Etravirine Etravirine The metabolism of Lomitapide can be increased when combined with Etravirine.
Mitoxantrone Injection Mitoxantrone Injection The metabolism of Lomitapide can be decreased when combined with Mitoxantrone.
Desvenlafaxine Desvenlafaxine The metabolism of Lomitapide can be decreased when combined with Desvenlafaxine.
Bendamustine Injection Bendamustine Injection The serum concentration of Bendamustine can be increased when it is combined with Lomitapide.
Pilocarpine Pilocarpine The metabolism of Lomitapide can be decreased when combined with Pilocarpine.
Certolizumab Injection Certolizumab Injection The metabolism of Lomitapide can be increased when combined with Certolizumab pegol.
Ixabepilone Injection Ixabepilone Injection The metabolism of Ixabepilone can be decreased when combined with Lomitapide.
Irinotecan Injection Irinotecan Injection The metabolism of Irinotecan can be decreased when combined with Lomitapide.
Mitotane Mitotane The metabolism of Lomitapide can be increased when combined with Mitotane.
Rufinamide Rufinamide The metabolism of Lomitapide can be increased when combined with Rufinamide.
Silodosin Silodosin The serum concentration of Silodosin can be increased when it is combined with Lomitapide.
Midazolam Midazolam The serum concentration of Midazolam can be increased when it is combined with Lomitapide.
Milnacipran Milnacipran The metabolism of Lomitapide can be decreased when combined with Milnacipran.
Iloperidone Iloperidone The metabolism of Iloperidone can be decreased when combined with Lomitapide.
Lacosamide Lacosamide The metabolism of Lacosamide can be decreased when combined with Lomitapide.
Everolimus Everolimus The serum concentration of Everolimus can be increased when it is combined with Lomitapide.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The serum concentration of Tolvaptan can be increased when it is combined with Lomitapide.
Dronedarone Dronedarone The serum concentration of Lomitapide can be increased when it is combined with Dronedarone.
Romidepsin Injection Romidepsin Injection The serum concentration of Lomitapide can be increased when it is combined with Romidepsin.
Topotecan Topotecan The serum concentration of Topotecan can be increased when it is combined with Lomitapide.
Golimumab Injection Golimumab Injection The metabolism of Lomitapide can be increased when combined with Golimumab.
Pazopanib Pazopanib The serum concentration of Pazopanib can be increased when it is combined with Lomitapide.
Albendazole Albendazole The metabolism of Albendazole can be decreased when combined with Lomitapide.
Tocilizumab Injection Tocilizumab Injection The metabolism of Lomitapide can be increased when combined with Tocilizumab.
Cabazitaxel Injection Cabazitaxel Injection The serum concentration of Lomitapide can be increased when it is combined with Cabazitaxel.
Acetaminophen Injection Acetaminophen Injection The metabolism of Lomitapide can be decreased when combined with Acetaminophen.
Denileukin Diftitox Injection Denileukin Diftitox Injection The metabolism of Lomitapide can be decreased when combined with Aldesleukin.
Busulfan Injection Busulfan Injection The metabolism of Lomitapide can be decreased when combined with Busulfan.
Roflumilast Roflumilast The metabolism of Roflumilast can be decreased when combined with Lomitapide.
Linagliptin Linagliptin The metabolism of Linagliptin can be decreased when combined with Lomitapide.
Rilpivirine Rilpivirine The metabolism of Rilpivirine can be decreased when combined with Lomitapide.
Telaprevir Telaprevir The metabolism of Glecaprevir can be decreased when combined with Lomitapide.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Lomitapide can be increased when combined with Cyclophosphamide.
Rivaroxaban Rivaroxaban The serum concentration of Rivaroxaban can be increased when it is combined with Lomitapide.
Ticagrelor Ticagrelor The metabolism of Ticagrelor can be decreased when combined with Lomitapide.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The serum concentration of Brentuximab vedotin can be increased when it is combined with Lomitapide.
Ruxolitinib Ruxolitinib The metabolism of Ruxolitinib can be decreased when combined with Lomitapide.
Vandetanib Vandetanib The metabolism of Vandetanib can be decreased when combined with Lomitapide.
Clobazam Clobazam The metabolism of Clobazam can be increased when combined with Lomitapide.
Vemurafenib Vemurafenib The metabolism of Vemurafenib can be decreased when combined with Lomitapide.
Ivacaftor Ivacaftor The metabolism of Lomitapide can be decreased when combined with Ivacaftor.
Axitinib Axitinib The metabolism of Axitinib can be decreased when combined with Lomitapide.
Crizotinib Crizotinib The metabolism of Lomitapide can be decreased when combined with Crizotinib.
Cabergoline Cabergoline The metabolism of Lomitapide can be decreased when combined with Cabergoline.
Naloxone Injection Naloxone Injection The metabolism of Lomitapide can be decreased when combined with Naloxone.
Ambrisentan Ambrisentan The serum concentration of Lomitapide can be increased when it is combined with Ambrisentan.
Carfilzomib Injection Carfilzomib Injection The serum concentration of Carfilzomib can be increased when it is combined with Lomitapide.
Enzalutamide Enzalutamide The metabolism of Lomitapide can be increased when combined with Enzalutamide.
Mirabegron Mirabegron The serum concentration of Lomitapide can be increased when it is combined with Mirabegron.
Regorafenib Regorafenib The serum concentration of Lomitapide can be increased when it is combined with Regorafenib.
Bosutinib Bosutinib The serum concentration of Bosutinib can be increased when it is combined with Lomitapide.
Corticotropin, Repository Injection Corticotropin, Repository Injection The metabolism of Lomitapide can be increased when combined with Corticotropin.
Mipomersen Injection Mipomersen Injection Lomitapide may increase the hepatotoxic activities of Mipomersen.
Tofacitinib Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Lomitapide.
Ponatinib Ponatinib The metabolism of Lomitapide can be decreased when combined with Ponatinib.
Pomalidomide Pomalidomide The serum concentration of Lomitapide can be increased when it is combined with Pomalidomide.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The serum concentration of Trastuzumab emtansine can be increased when it is combined with Lomitapide.
Apixaban Apixaban The serum concentration of Lomitapide can be increased when it is combined with Apixaban.
Canagliflozin Canagliflozin The serum concentration of Lomitapide can be increased when it is combined with Canagliflozin.
Dabrafenib Dabrafenib The serum concentration of Dabrafenib can be increased when it is combined with Lomitapide.
Trametinib Trametinib The metabolism of Lomitapide can be increased when combined with Trametinib.
Dolutegravir Dolutegravir The serum concentration of Dolutegravir can be increased when it is combined with Lomitapide.
Afatinib Afatinib The serum concentration of Afatinib can be increased when it is combined with Lomitapide.
Perampanel Perampanel The metabolism of Lomitapide can be increased when combined with Perampanel.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Lomitapide.
Simeprevir Simeprevir The metabolism of Simeprevir can be decreased when combined with Lomitapide.
Sofosbuvir Sofosbuvir The serum concentration of Sofosbuvir can be increased when it is combined with Lomitapide.
Apremilast Apremilast The metabolism of Lomitapide can be increased when combined with Apremilast.
Ceritinib Ceritinib The metabolism of Lomitapide can be decreased when combined with Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Lomitapide can be decreased when combined with Siltuximab.
Eslicarbazepine Eslicarbazepine The metabolism of Lomitapide can be increased when combined with Eslicarbazepine.
Belinostat Injection Belinostat Injection The serum concentration of Belinostat can be increased when it is combined with Lomitapide.
Idelalisib Idelalisib The metabolism of Idelalisib can be decreased when combined with Lomitapide.
Testosterone Injection Testosterone Injection The metabolism of Lomitapide can be increased when combined with Testosterone.
Oritavancin Injection Oritavancin Injection The metabolism of Lomitapide can be increased when combined with Oritavancin.
Vorapaxar Vorapaxar The metabolism of Vorapaxar can be decreased when combined with Lomitapide.
Suvorexant Suvorexant The metabolism of Suvorexant can be decreased when combined with Lomitapide.
Edoxaban Edoxaban The serum concentration of Edoxaban can be increased when it is combined with Lomitapide.
Olaparib Olaparib The metabolism of Lomitapide can be decreased when combined with Olaparib.
Tasimelteon Tasimelteon The metabolism of Tasimelteon can be decreased when combined with Lomitapide.
Lanreotide Injection Lanreotide Injection The metabolism of Lomitapide can be decreased when combined with Lanreotide.
Nintedanib Nintedanib The metabolism of Nintedanib can be decreased when combined with Lomitapide.
Secukinumab Injection Secukinumab Injection The metabolism of Lomitapide can be increased when combined with Secukinumab.
Palbociclib Palbociclib The metabolism of Lomitapide can be decreased when combined with Palbociclib.
Lenvatinib Lenvatinib The metabolism of Lomitapide can be decreased when combined with Lenvatinib.
Naloxegol Naloxegol The serum concentration of Naloxegol can be increased when it is combined with Lomitapide.
Panobinostat Panobinostat The metabolism of Lomitapide can be decreased when combined with Panobinostat.
Haloperidol Injection Haloperidol Injection The serum concentration of Lomitapide can be increased when it is combined with Haloperidol.
Isavuconazonium Injection Isavuconazonium Injection The metabolism of Lomitapide can be increased when combined with Isavuconazonium.
Sonidegib Sonidegib The metabolism of Sonidegib can be decreased when combined with Lomitapide.
Prednisolone Prednisolone The metabolism of Lomitapide can be increased when combined with Prednisolone.
Ziprasidone Injection Ziprasidone Injection The metabolism of Lomitapide can be decreased when combined with Ziprasidone.
Cobimetinib Cobimetinib The serum concentration of Cobimetinib can be increased when it is combined with Lomitapide.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Lomitapide.
Osimertinib Osimertinib The metabolism of Lomitapide can be decreased when combined with Osimertinib.
Alectinib Alectinib The metabolism of Alectinib can be decreased when combined with Lomitapide.
Ixazomib Ixazomib The metabolism of Ixazomib can be decreased when combined with Lomitapide.
Rifapentine Rifapentine The metabolism of Lomitapide can be increased when combined with Rifapentine.
Lesinurad Lesinurad The metabolism of Lomitapide can be increased when combined with Lesinurad.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The metabolism of Lomitapide can be decreased when combined with Amphotericin B.
Dexamethasone Injection Dexamethasone Injection The metabolism of Lomitapide can be decreased when combined with Dexamethasone.
Venetoclax Venetoclax The metabolism of Venetoclax can be decreased when combined with Lomitapide.
Cobicistat Cobicistat The metabolism of Lomitapide can be decreased when combined with Cobicistat.
Selexipag Selexipag The serum concentration of Lomitapide can be increased when it is combined with Selexipag.
Rucaparib Rucaparib The metabolism of Lomitapide can be decreased when combined with Rucaparib.
Ribociclib Ribociclib The metabolism of Lomitapide can be decreased when combined with Ribociclib.
Brigatinib Brigatinib The metabolism of Lomitapide can be decreased when combined with Brigatinib.
Deflazacort Deflazacort The metabolism of Lomitapide can be increased when combined with Deflazacort.
Sarilumab Injection Sarilumab Injection The metabolism of Lomitapide can be decreased when combined with Sarilumab.
Midostaurin Midostaurin The metabolism of Lomitapide can be decreased when combined with Midostaurin.
Neratinib Neratinib The metabolism of Neratinib can be decreased when combined with Lomitapide.
Enasidenib Enasidenib The metabolism of Lomitapide can be decreased when combined with Enasidenib.
Inotuzumab Ozogamicin Injection Inotuzumab Ozogamicin Injection The serum concentration of Inotuzumab ozogamicin can be increased when it is combined with Lomitapide.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Lomitapide can be decreased when combined with Fosaprepitant.
Copanlisib Injection Copanlisib Injection The serum concentration of Lomitapide can be increased when it is combined with Copanlisib.
Abemaciclib Abemaciclib The metabolism of Abemaciclib can be decreased when combined with Lomitapide.
Betrixaban Betrixaban The serum concentration of Betrixaban can be increased when it is combined with Lomitapide.
Acalabrutinib Acalabrutinib The metabolism of Lomitapide can be decreased when combined with Acalabrutinib.
Letermovir Letermovir The metabolism of Lomitapide can be decreased when combined with Letermovir.
Ertugliflozin Ertugliflozin The serum concentration of Ertugliflozin can be increased when it is combined with Lomitapide.
Buprenorphine Injection Buprenorphine Injection The metabolism of Lomitapide can be decreased when combined with Buprenorphine.
Apalutamide Apalutamide The metabolism of Lomitapide can be increased when combined with Apalutamide.
Fostamatinib Fostamatinib The metabolism of Lomitapide can be decreased when combined with Fostamatinib.
Avatrombopag Avatrombopag The serum concentration of Avatrombopag can be increased when it is combined with Lomitapide.
Baricitinib Baricitinib The metabolism of Lomitapide can be decreased when combined with Baricitinib.
Eliglustat Eliglustat The metabolism of Eliglustat can be decreased when combined with Lomitapide.
Binimetinib Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Lomitapide.
Ivosidenib Ivosidenib The metabolism of Ivosidenib can be decreased when combined with Lomitapide.
Lusutrombopag Lusutrombopag The serum concentration of Lusutrombopag can be increased when it is combined with Lomitapide.
Elagolix Elagolix The serum concentration of Elagolix can be increased when it is combined with Lomitapide.
Dacomitinib Dacomitinib The serum concentration of Dacomitinib can be increased when it is combined with Lomitapide.
Duvelisib Duvelisib The metabolism of Duvelisib can be decreased when combined with Lomitapide.
Omadacycline Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Lomitapide.
Stiripentol Stiripentol The metabolism of Lomitapide can be decreased when combined with Stiripentol.
Talazoparib Talazoparib The serum concentration of Talazoparib can be increased when it is combined with Lomitapide.
Gilteritinib Gilteritinib The metabolism of Gilteritinib can be decreased when combined with Lomitapide.
Glasdegib Glasdegib The serum concentration of Lomitapide can be increased when it is combined with Glasdegib.
Larotrectinib Larotrectinib The serum concentration of Lomitapide can be increased when it is combined with Larotrectinib.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Lomitapide can be decreased when combined with Paclitaxel.
Rifamycin Rifamycin The metabolism of Rifamycin can be increased when combined with Lomitapide.
Prucalopride Prucalopride The serum concentration of Prucalopride can be increased when it is combined with Lomitapide.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Lomitapide can be increased when combined with Emapalumab.
Siponimod Siponimod The metabolism of Siponimod can be decreased when combined with Lomitapide.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Lomitapide.
Alpelisib Alpelisib The metabolism of Lomitapide can be decreased when combined with Alpelisib.
Darolutamide Darolutamide The serum concentration of Darolutamide can be increased when it is combined with Lomitapide.
Triclabendazole Triclabendazole The metabolism of Lomitapide can be decreased when combined with Triclabendazole.
Entrectinib Entrectinib The metabolism of Entrectinib can be decreased when combined with Lomitapide.
Pexidartinib Pexidartinib Lomitapide may increase the hepatotoxic activities of Pexidartinib.
Pitolisant Pitolisant The serum concentration of Lomitapide can be decreased when it is combined with Pitolisant.
Fedratinib Fedratinib The serum concentration of Fedratinib can be increased when it is combined with Lomitapide.
Lefamulin Lefamulin Lomitapide may decrease the excretion rate of Lefamulin which could result in a higher serum level.
Phenytoin Injection Phenytoin Injection The metabolism of Lomitapide can be increased when combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Lomitapide can be increased when combined with Fosphenytoin.
Enfortumab vedotin-ejfv Injection Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be increased when it is combined with Lomitapide.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Lomitapide.
Voxelotor Voxelotor The serum concentration of Voxelotor can be increased when it is combined with Lomitapide.
Lasmiditan Lasmiditan The serum concentration of Lasmiditan can be increased when it is combined with Lomitapide.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Lomitapide.
Tazemetostat Tazemetostat The metabolism of Tazemetostat can be decreased when combined with Lomitapide.
Cenobamate Cenobamate The serum concentration of Lomitapide can be decreased when it is combined with Cenobamate.
Selumetinib Selumetinib The serum concentration of Selumetinib can be increased when it is combined with Lomitapide.
Rimegepant Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Lomitapide.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Lomitapide.
Remdesivir Injection Remdesivir Injection The serum concentration of Remdesivir can be increased when it is combined with Lomitapide.
Ripretinib Ripretinib The serum concentration of Ripretinib can be increased when it is combined with Lomitapide.
Lemborexant Lemborexant The serum concentration of Lemborexant can be increased when it is combined with Lomitapide.
Fostemsavir Fostemsavir The serum concentration of Fostemsavir can be increased when it is combined with Lomitapide.
Octreotide Octreotide The serum concentration of Lomitapide can be increased when it is combined with Octreotide.
Belantamab Mafodotin-blmf Injection Belantamab Mafodotin-blmf Injection The serum concentration of Belantamab mafodotin can be increased when it is combined with Lomitapide.
Pralsetinib Pralsetinib The serum concentration of Pralsetinib can be increased when it is combined with Lomitapide.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Lomitapide can be decreased when it is combined with Satralizumab.
Relugolix Relugolix The serum concentration of Relugolix can be increased when it is combined with Lomitapide.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Drospirenone can be decreased when combined with Lomitapide.
Vitamin E (Alpha-Tocopherol) Vitamin E (Alpha-Tocopherol) The metabolism of Lomitapide can be increased when combined with Vitamin E.
Theophylline Theophylline The metabolism of Lomitapide can be decreased when combined with Theophylline.
Phenobarbital Phenobarbital The metabolism of Lomitapide can be increased when combined with Phenobarbital.
Methotrexate Injection Methotrexate Injection The metabolism of Methotrexate can be decreased when combined with Lomitapide.
Primidone Primidone The metabolism of Lomitapide can be increased when combined with Primidone.
Chlorpromazine Chlorpromazine The metabolism of Lomitapide can be increased when combined with Chlorpromazine.
Diazepam Diazepam The metabolism of Lomitapide can be decreased when combined with Diazepam.
Lorazepam Lorazepam The metabolism of Lorazepam can be decreased when combined with Lomitapide.
Bromocriptine Bromocriptine The metabolism of Lomitapide can be decreased when combined with Bromocriptine.
Tranylcypromine Tranylcypromine The metabolism of Lomitapide can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine The metabolism of Lomitapide can be decreased when combined with Phenelzine.
Tetracycline Tetracycline The metabolism of Lomitapide can be decreased when combined with Tetracycline.
Prochlorperazine Prochlorperazine The metabolism of Prochlorperazine can be decreased when combined with Lomitapide.
Methadone Methadone The metabolism of Lomitapide can be increased when combined with Methadone.
Oxybutynin Oxybutynin The metabolism of Lomitapide can be decreased when combined with Oxybutynin.
Colestipol Colestipol Colestipol can cause a decrease in the absorption of Lomitapide resulting in a reduced serum concentration and potentially a decrease in efficacy.
Orphenadrine Orphenadrine The metabolism of Lomitapide can be decreased when combined with Orphenadrine.
Phentermine Phentermine The metabolism of Phentermine can be decreased when combined with Lomitapide.
Hydrocortisone Hydrocortisone The metabolism of Lomitapide can be increased when combined with Hydrocortisone.
Doxorubicin Doxorubicin The serum concentration of Doxorubicin can be increased when it is combined with Lomitapide.
Dactinomycin Dactinomycin The serum concentration of Dactinomycin can be increased when it is combined with Lomitapide.
Carbamazepine Carbamazepine The metabolism of Carbamazepine can be decreased when combined with Lomitapide.
Clonidine Clonidine The metabolism of Clonidine can be decreased when combined with Lomitapide.
Hydralazine Hydralazine The metabolism of Lomitapide can be decreased when combined with Hydralazine.
Cimetidine Cimetidine The metabolism of Cimetidine can be decreased when combined with Lomitapide.
Warfarin Warfarin The serum concentration of Warfarin can be increased when it is combined with Lomitapide.
Loperamide Loperamide The metabolism of Loperamide can be decreased when combined with Lomitapide.
Daunorubicin Daunorubicin The metabolism of Lomitapide can be decreased when combined with Daunorubicin.
Griseofulvin Griseofulvin The metabolism of Lomitapide can be increased when combined with Griseofulvin.
Digoxin Digoxin Lomitapide may decrease the excretion rate of Digoxin which could result in a higher serum level.
Quinine Quinine The metabolism of Quinine can be increased when combined with Lomitapide.
Calcitriol Calcitriol The metabolism of Lomitapide can be increased when combined with Calcitriol.
Sulfinpyrazone Sulfinpyrazone The metabolism of Lomitapide can be increased when combined with Sulfinpyrazone.
Secobarbital Secobarbital The metabolism of Lomitapide can be increased when combined with Secobarbital.
Desipramine Desipramine The metabolism of Desipramine can be decreased when combined with Lomitapide.
Imipramine Imipramine The serum concentration of Imipramine can be increased when it is combined with Lomitapide.
Probenecid Probenecid The metabolism of Lomitapide can be increased when combined with Probenecid.
Quinidine Quinidine The metabolism of Lomitapide can be decreased when combined with Quinidine.
Isoniazid Isoniazid The metabolism of Lomitapide can be decreased when combined with Isoniazid.
Rifampin Rifampin The metabolism of Lomitapide can be increased when combined with Rifampicin.
Valproic Acid Valproic Acid The metabolism of Lomitapide can be decreased when combined with Valproic acid.
Tamoxifen Tamoxifen The metabolism of Lomitapide can be decreased when combined with Tamoxifen.
Methimazole Methimazole The metabolism of Lomitapide can be decreased when combined with Methimazole.
Niacin Niacin The metabolism of Lomitapide can be decreased when combined with Niacin.
Danazol Danazol The metabolism of Lomitapide can be decreased when combined with Danazol.
Nortriptyline Nortriptyline The serum concentration of Nortriptyline can be increased when it is combined with Lomitapide.
Amphotericin B Injection Amphotericin B Injection The metabolism of Lomitapide can be decreased when combined with Amphotericin B.
Cholestyramine Resin Cholestyramine Resin Cholestyramine can cause a decrease in the absorption of Lomitapide resulting in a reduced serum concentration and potentially a decrease in efficacy.
Clomiphene Clomiphene The serum concentration of Clomifene can be increased when it is combined with Lomitapide.
Colchicine Colchicine The metabolism of Colchicine can be decreased when combined with Lomitapide.
Cephalexin Cephalexin The metabolism of Cephalexin can be decreased when combined with Lomitapide.
Acetazolamide Acetazolamide The metabolism of Lomitapide can be decreased when combined with Acetazolamide.
Ketoconazole Ketoconazole The metabolism of Lomitapide can be decreased when combined with Ketoconazole.
Thiotepa Injection Thiotepa Injection The metabolism of Thiotepa can be decreased when combined with Lomitapide.
Vincristine Injection Vincristine Injection The excretion of Vincristine can be decreased when combined with Lomitapide.
Vinblastine Vinblastine The metabolism of Vinblastine can be decreased when combined with Lomitapide.
Metoprolol Metoprolol The metabolism of Metoprolol can be decreased when combined with Lomitapide.
Alprazolam Alprazolam The metabolism of Alprazolam can be decreased when combined with Lomitapide.
Diltiazem Diltiazem The metabolism of Lomitapide can be decreased when combined with Diltiazem.
Nifedipine Nifedipine The metabolism of Lomitapide can be increased when combined with Nifedipine.
Verapamil Verapamil The metabolism of Lomitapide can be decreased when combined with Verapamil.
Etoposide Etoposide The serum concentration of Etoposide can be increased when it is combined with Lomitapide.
Glyburide Glyburide The metabolism of Lomitapide can be decreased when combined with Glyburide.
Dicloxacillin Dicloxacillin The metabolism of Lomitapide can be increased when combined with Dicloxacillin.
Nafcillin Injection Nafcillin Injection The metabolism of Lomitapide can be increased when combined with Nafcillin.
Pimozide Pimozide The metabolism of Pimozide can be decreased when combined with Lomitapide.
Amiodarone Amiodarone The metabolism of Amiodarone can be decreased when combined with Lomitapide.
Lovastatin Lovastatin The serum concentration of Lovastatin can be increased when it is combined with Lomitapide.
Ciprofloxacin Ciprofloxacin The metabolism of Lomitapide can be decreased when combined with Ciprofloxacin.
Clozapine Clozapine The metabolism of Lomitapide can be increased when combined with Clozapine.
Clarithromycin Clarithromycin The metabolism of Lomitapide can be decreased when combined with Clarithromycin.
Felodipine Felodipine The metabolism of Lomitapide can be decreased when combined with Felodipine.
Pravastatin Pravastatin The serum concentration of Pravastatin can be increased when it is combined with Lomitapide.
Simvastatin Simvastatin The serum concentration of Simvastatin can be increased when it is combined with Lomitapide.
Teniposide Injection Teniposide Injection The metabolism of Lomitapide can be decreased when combined with Teniposide.
Itraconazole Itraconazole The metabolism of Lomitapide can be decreased when combined with Itraconazole.
Rifabutin Rifabutin The metabolism of Lomitapide can be increased when combined with Rifabutin.
Bisoprolol Bisoprolol The serum concentration of Lomitapide can be increased when it is combined with Bisoprolol.
Doxazosin Doxazosin The metabolism of Doxazosin can be decreased when combined with Lomitapide.
Isradipine Isradipine The metabolism of Lomitapide can be decreased when combined with Isradipine.
Omeprazole Omeprazole The metabolism of Lomitapide can be increased when combined with Omeprazole.
Cisapride Cisapride The metabolism of Lomitapide can be decreased when combined with Cisapride.
Fluvastatin Fluvastatin The metabolism of Lomitapide can be decreased when combined with Fluvastatin.
Famciclovir Famciclovir The metabolism of Famciclovir can be decreased when combined with Lomitapide.
Fluvoxamine Fluvoxamine The metabolism of Lomitapide can be decreased when combined with Fluvoxamine.
Nefazodone Nefazodone The metabolism of Lomitapide can be decreased when combined with Nefazodone.
Losartan Losartan The metabolism of Lomitapide can be decreased when combined with Losartan.
Tramadol Tramadol The metabolism of Lomitapide can be decreased when combined with Tramadol.
Vinorelbine Injection Vinorelbine Injection The metabolism of Vinorelbine can be decreased when combined with Lomitapide.
Lansoprazole Lansoprazole The metabolism of Lomitapide can be increased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The metabolism of Lomitapide can be decreased when combined with Ifosfamide.
Nicardipine Nicardipine The metabolism of Lomitapide can be decreased when combined with Nicardipine.
Ticlopidine Ticlopidine The metabolism of Ticlopidine can be decreased when combined with Lomitapide.
Saquinavir Saquinavir The metabolism of Saquinavir can be decreased when combined with Lomitapide.
Gemcitabine Injection Gemcitabine Injection The serum concentration of Gemcitabine can be increased when it is combined with Lomitapide.
Ritonavir Ritonavir The serum concentration of Lomitapide can be increased when it is combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Lomitapide can be decreased when combined with Docetaxel.
Clomipramine Clomipramine The metabolism of Clomipramine can be decreased when combined with Lomitapide.
Zafirlukast Zafirlukast The metabolism of Zafirlukast can be decreased when combined with Lomitapide.
Mirtazapine Mirtazapine The metabolism of Lomitapide can be decreased when combined with Mirtazapine.
Topiramate Topiramate The metabolism of Lomitapide can be increased when combined with Topiramate.
Fexofenadine Fexofenadine The serum concentration of Fexofenadine can be increased when it is combined with Lomitapide.
Azithromycin Azithromycin The metabolism of Azithromycin can be decreased when combined with Lomitapide.
Bicalutamide Bicalutamide The metabolism of Lomitapide can be decreased when combined with Bicalutamide.
Raloxifene Raloxifene The metabolism of Lomitapide can be decreased when combined with Raloxifene.
Irbesartan Irbesartan The metabolism of Lomitapide can be decreased when combined with Irbesartan.
Paroxetine Paroxetine The metabolism of Lomitapide can be decreased when combined with Paroxetine.
Citalopram Citalopram The metabolism of Lomitapide can be decreased when combined with Citalopram.
Efavirenz Efavirenz The metabolism of Lomitapide can be increased when combined with Efavirenz.
Sildenafil Sildenafil The serum concentration of Sildenafil can be increased when it is combined with Lomitapide.
Colesevelam Colesevelam Colesevelam can cause a decrease in the absorption of Lomitapide resulting in a reduced serum concentration and potentially a decrease in efficacy.
Rabeprazole Rabeprazole The metabolism of Lomitapide can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Lomitapide can be increased when combined with Terbinafine.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists

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