Vandetanib

Generic name: Pronounced as (van det' a nib)
Brand names
  • Caprelsa®
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Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 11/15/2016

Vandetanib may cause QT prolongation (an irregular heart rhythm that can lead to fainting, loss of consciousness, seizures, or sudden death). Tell your doctor if you or anyone in your family has or has ever had long QT syndrome (an inherited condition in which a person is more likely to have QT prolongation) or you have or have ever had low levels of calcium, potassium or magnesium in your blood, an irregular heartbeat, heart failure, or a heart attack. Tell your doctor and pharmacist if you are taking chloroquine (Aralen); clarithromycin (Biaxin, in Prevpac); haloperidol (Haldol); medications for an irregular heartbeat such as amiodarone (Cordarone, Pacerone), disopyramide (Norpace), dofetilide (Tikosyn), procainamide, and sotalol (Betapace); certain medications for nausea such as dolasetron (Anzemet) and granisetron (Sancuso); methadone (Dolophine, Methadose); moxifloxacin (Avelox); and pimozide (Orap). If you experience any of the following symptoms, stop taking vandetanib and call your doctor immediately or get emergency medical treatment: fast, pounding, or irregular heartbeat; fainting; lightheadedness; or loss of consciousness. Vandetanib may remain in your body for several months after you stop taking the medication, so you may continue to be at risk of side effects during that time.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests, such as blood tests and electrocardiograms (EKGs, tests that record the electrical activity of the heart) before and regularly during your treatment to be sure that it is safe for you to take vandetanib. Your doctor will also order these tests any time that your dose of vandetanib is changed or if you begin taking certain new medications.

A program called Caprelsa Risk Evaluation and Mitigation Strategy (REMS) has been set up to manage the risks of this medication. You will only be able to receive vandetanib if the doctor who prescribes your medication is enrolled in the program. You can only receive the medication from a pharmacy that participates in the program. Ask your doctor if you have any questions about participating in the program or how to get your medication.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with vandetanib and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm)or the manufacturer's website to obtain the Medication Guide.

Talk to your doctor about the risks of taking vandetanib.

Vandetanib is used to treat a certain type of thyroid cancer that cannot be treated by surgery or that has spread to other parts of the body. Vandetanib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps slow or stop the spread of cancer cells.

Vandetanib comes as a tablet to take by mouth. It is usually taken with or without food once a day. Take vandetanib at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take vandetanib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the tablets whole with a glass of water. Do not split, chew, or crush them. If a tablet is accidentally crushed, avoid contact with your skin. If any contact occurs, wash the affected area well with water.

If you are unable to swallow the tablets whole, you may dissolve them in water. Place the tablet in a glass that contains 2 ounces of plain, non-carbonated drinking water. Do not use any other liquid to dissolve the tablet. Stir the mixture for about 10 minutes until the tablet is in very small pieces; the tablet will not dissolve completely. Drink the mixture right away. Rinse the glass with another 4 ounces of non-carbonated water and drink the rinse water to be sure that you swallow all of the medication.

Your doctor may decrease your dose of vandetanib or tell you to stop taking vandetanib for a period of time during your treatment. This depends on how well the medication works for you and the side effects you experience. Talk to your doctor about how you are feeling during your treatment. Continue to take vandetanib even if you feel well. Do not stop taking vandetanib without talking to your doctor.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking vandetanib,

  • tell your doctor and pharmacist if you are allergic to vandetanib, any other medications, or any of the ingredients in vandetanib tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: carbamazepine (Tegretol, Carbatrol, Equetro), dexamethasone, phenobarbital, phenytoin (Dilantin, Phenytek), rifabutin (Mycobutin), rifampin (Rifadin, in Rifamate), rifapentin (Priftin), and thyroid hormones such as levothyroxine (Synthroid). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with vandetanib, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

  • tell your doctor what herbal products you are taking, especially St. Johns Wort.

  • tell your doctor if you have recently coughed up blood or had any other type of bleeding problems and if you have or have ever had high blood pressure, any type of skin disease, seizures, or lung, kidney or liver disease.

  • tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while you are taking vandetanib and for at least 4 months after your treatment. Talk to your doctor about birth control methods that you can use during your treatment. If you become pregnant while taking vandetanib, call your doctor immediately. Vandetanib may harm the fetus.

  • tell your doctor if you are breast-feeding.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking vandetanib.

  • you should know that vandetanib may make you feel drowsy, weak, or cause blurred vision. Do not drive a car or operate machinery until you know how this medication affects you.

  • plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Vandetanib may make your skin sensitive to sunlight during your treatment and for at least 4 months after stopping your treatment.

Unless your doctor tells you otherwise, continue your normal diet.

If your next dose is due in 12 hours or more, take the missed dose as soon as you remember it. However, if the next dose will be taken in less than 12 hours, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Vandetanib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • nausea

    • vomiting

    • heartburn

    • loss of appetite

    • weight loss

    • stomach pain

    • runny nose

    • extreme tiredness

    • weakness

    • difficulty falling asleep or staying asleep

    • depression

  • Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately or get emergency medical treatment:

    • diarrhea

    • rash or acne

    • dry, peeling, or itchy skin

    • blisters or sores on the skin or in the mouth

    • redness of the face, hands, or soles of the feet

    • muscle or joint aches

    • fever

    • chest pain (which may get worse with deep breaths or cough)

    • hiccups or rapid breathing

    • sudden shortness of breath

    • persistent cough

    • swelling of the hands, feet, ankles, or lower legs

    • sudden weight gain

    • numbness or weakness of the face, arm, or leg, especially on one side of the body

    • sudden confusion

    • difficulty speaking or understanding

    • sudden trouble seeing in one or both eyes

    • sudden trouble walking or balancing

    • sudden severe headache

    • seizures

    • unusual bruising or bleeding

  • Vandetanib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to vandetanib. Your doctor will also check your blood pressure regularly during your treatment with vandetanib.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Moxifloxacin Moxifloxacin The risk or severity of QTc prolongation can be increased when Moxifloxacin is combined with Vandetanib.
Leflunomide Leflunomide Vandetanib may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Delavirdine Delavirdine The metabolism of Vandetanib can be decreased when combined with Delavirdine.
Dolasetron Dolasetron The risk or severity of QTc prolongation can be increased when Dolasetron is combined with Vandetanib.
Anagrelide Anagrelide The risk or severity of QTc prolongation can be increased when Anagrelide is combined with Vandetanib.
Cilostazol Cilostazol The risk or severity of QTc prolongation can be increased when Cilostazol is combined with Vandetanib.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The metabolism of Vandetanib can be decreased when combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Vandetanib may decrease the excretion rate of Conjugated estrogens which could result in a higher serum level.
Fenofibrate Fenofibrate The metabolism of Vandetanib can be decreased when combined with Fenofibrate.
Methylergonovine Methylergonovine The metabolism of Vandetanib can be decreased when combined with Methylergometrine.
Paregoric Paregoric The serum concentration of Morphine can be increased when it is combined with Vandetanib.
Penbutolol Penbutolol The risk or severity of QTc prolongation can be increased when Acebutolol is combined with Vandetanib.
Ranitidine Ranitidine The serum concentration of Ranitidine can be increased when it is combined with Vandetanib.
Reserpine Reserpine The serum concentration of Reserpine can be increased when it is combined with Vandetanib.
Sumatriptan Sumatriptan Vandetanib may decrease the excretion rate of Sumatriptan which could result in a higher serum level.
Tacrolimus Tacrolimus The metabolism of Vandetanib can be decreased when combined with Tacrolimus.
Tizanidine Tizanidine The risk or severity of QTc prolongation can be increased when Tizanidine is combined with Vandetanib.
Triamcinolone Triamcinolone The metabolism of Vandetanib can be increased when combined with Triamcinolone.
Doxycycline Injection Doxycycline Injection The metabolism of Vandetanib can be decreased when combined with Doxycycline.
Famotidine Injection Famotidine Injection The risk or severity of QTc prolongation can be increased when Famotidine is combined with Vandetanib.
Fluconazole Injection Fluconazole Injection The metabolism of Vandetanib can be decreased when combined with Fluconazole.
Foscarnet Injection Foscarnet Injection The risk or severity of QTc prolongation can be increased when Foscarnet is combined with Vandetanib.
Levofloxacin Injection Levofloxacin Injection The risk or severity of QTc prolongation can be increased when Levofloxacin is combined with Vandetanib.
Meperidine Injection Meperidine Injection The metabolism of Vandetanib can be increased when combined with Meperidine.
Methylprednisolone Injection Methylprednisolone Injection The metabolism of Vandetanib can be increased when combined with Methylprednisolone.
Metoclopramide Injection Metoclopramide Injection The risk or severity of QTc prolongation can be increased when Metoclopramide is combined with Vandetanib.
Metronidazole Injection Metronidazole Injection The metabolism of Vandetanib can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection The serum concentration of Morphine can be increased when it is combined with Vandetanib.
Zidovudine Injection Zidovudine Injection Vandetanib may decrease the excretion rate of Zidovudine which could result in a higher serum level.
Cyclosporine Cyclosporine The serum concentration of Cyclosporine can be increased when it is combined with Vandetanib.
Ondansetron Ondansetron The risk or severity of QTc prolongation can be increased when Ondansetron is combined with Vandetanib.
Granisetron Granisetron The risk or severity of QTc prolongation can be increased when Granisetron is combined with Vandetanib.
Olanzapine Olanzapine The risk or severity of QTc prolongation can be increased when Olanzapine is combined with Vandetanib.
Dofetilide Dofetilide The risk or severity of QTc prolongation can be increased when Dofetilide is combined with Vandetanib.
Hydroxychloroquine Hydroxychloroquine The risk or severity of QTc prolongation can be increased when Hydroxychloroquine is combined with Vandetanib.
Orlistat Orlistat The metabolism of Vandetanib can be increased when combined with Orlistat.
Oxcarbazepine Oxcarbazepine The metabolism of Vandetanib can be increased when combined with Oxcarbazepine.
Anakinra Anakinra The metabolism of Vandetanib can be increased when combined with Anakinra.
Desloratadine Desloratadine The risk or severity of QTc prolongation can be increased when Desloratadine is combined with Vandetanib.
Trimipramine Trimipramine The serum concentration of Vandetanib can be increased when it is combined with Trimipramine.
Etanercept Injection Etanercept Injection The metabolism of Vandetanib can be increased when combined with Etanercept.
Modafinil Modafinil The metabolism of Vandetanib can be increased when combined with Modafinil.
Tenofovir Tenofovir The metabolism of Tenofovir can be decreased when combined with Vandetanib.
Sirolimus Sirolimus The serum concentration of Sirolimus can be increased when it is combined with Vandetanib.
Epinephrine Injection Epinephrine Injection The metabolism of Epinephrine can be decreased when combined with Vandetanib.
Escitalopram Escitalopram The risk or severity of QTc prolongation can be increased when Escitalopram is combined with Vandetanib.
Zonisamide Zonisamide The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Vandetanib.
Adalimumab Injection Adalimumab Injection The metabolism of Vandetanib can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The risk or severity of QTc prolongation can be increased when Aripiprazole is combined with Vandetanib.
Atomoxetine Atomoxetine The risk or severity of QTc prolongation can be increased when Atomoxetine is combined with Vandetanib.
Ezetimibe Ezetimibe Vandetanib may decrease the excretion rate of Ezetimibe which could result in a higher serum level.
Teriparatide Injection Teriparatide Injection The therapeutic efficacy of Teriparatide can be decreased when used in combination with Vandetanib.
Atazanavir Atazanavir The metabolism of Vandetanib can be decreased when combined with Atazanavir.
Mefloquine Mefloquine The metabolism of Vandetanib can be decreased when combined with Mefloquine.
Rosuvastatin Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Vandetanib.
Vardenafil Vardenafil The serum concentration of Vardenafil can be increased when it is combined with Vandetanib.
Alfuzosin Alfuzosin The risk or severity of QTc prolongation can be increased when Alfuzosin is combined with Vandetanib.
Aprepitant Aprepitant The metabolism of Vandetanib can be decreased when combined with Aprepitant.
Memantine Memantine The serum concentration of Memantine can be increased when it is combined with Vandetanib.
Tegaserod Tegaserod Vandetanib may decrease the excretion rate of Tegaserod which could result in a higher serum level.
Gemifloxacin Gemifloxacin The risk or severity of QTc prolongation can be increased when Gemifloxacin is combined with Vandetanib.
Progesterone Progesterone The metabolism of Vandetanib can be increased when combined with Progesterone.
Apomorphine Injection Apomorphine Injection The risk or severity of QTc prolongation can be increased when Apomorphine is combined with Vandetanib.
Darbepoetin Alfa Injection Darbepoetin Alfa Injection The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Vandetanib.
Infliximab Injection Infliximab Injection The metabolism of Vandetanib can be increased when combined with Infliximab.
Protriptyline Protriptyline The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Vandetanib.
Rifaximin Rifaximin The serum concentration of Rifaximin can be increased when it is combined with Vandetanib.
Duloxetine Duloxetine The metabolism of Vandetanib can be decreased when combined with Duloxetine.
Norethindrone Norethindrone The metabolism of Vandetanib can be decreased when combined with Norethisterone.
Bosentan Bosentan The metabolism of Vandetanib can be increased when combined with Bosentan.
Erlotinib Erlotinib The metabolism of Vandetanib can be decreased when combined with Erlotinib.
Solifenacin Solifenacin The risk or severity of QTc prolongation can be increased when Solifenacin is combined with Vandetanib.
Voriconazole Voriconazole The metabolism of Vandetanib can be decreased when combined with Voriconazole.
Ibandronate Ibandronate The risk or severity of QTc prolongation can be increased when Ibandronate is combined with Vandetanib.
Pregabalin Pregabalin The risk or severity of QTc prolongation can be increased when Pregabalin is combined with Vandetanib.
Deferasirox Deferasirox The metabolism of Vandetanib can be increased when combined with Deferasirox.
Tipranavir Tipranavir The metabolism of Tipranavir can be decreased when combined with Vandetanib.
Felbamate Felbamate The metabolism of Vandetanib can be increased when combined with Felbamate.
Ranolazine Ranolazine The serum concentration of Ranolazine can be increased when it is combined with Vandetanib.
Abatacept Injection Abatacept Injection The metabolism of Vandetanib can be increased when combined with Abatacept.
Imatinib Imatinib The metabolism of Vandetanib can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin The serum concentration of Sitagliptin can be increased when it is combined with Vandetanib.
Varenicline Varenicline The excretion of Varenicline can be decreased when combined with Vandetanib.
Gefitinib Gefitinib The metabolism of Gefitinib can be decreased when combined with Vandetanib.
Albuterol Albuterol The risk or severity of QTc prolongation can be increased when Salbutamol is combined with Vandetanib.
Paliperidone Paliperidone The risk or severity of QTc prolongation can be increased when Paliperidone is combined with Vandetanib.
Bortezomib Bortezomib The serum concentration of Vandetanib can be increased when it is combined with Bortezomib.
Clofarabine Injection Clofarabine Injection The serum concentration of Clofarabine can be increased when it is combined with Vandetanib.
Oxaliplatin Injection Oxaliplatin Injection The risk or severity of QTc prolongation can be increased when Oxaliplatin is combined with Vandetanib.
Posaconazole Posaconazole The metabolism of Vandetanib can be decreased when combined with Posaconazole.
Primaquine Primaquine The metabolism of Vandetanib can be decreased when combined with Primaquine.
Darunavir Darunavir The serum concentration of Vandetanib can be increased when it is combined with Darunavir.
Dimenhydrinate Dimenhydrinate The risk or severity of QTc prolongation can be increased when Dimenhydrinate is combined with Vandetanib.
Vorinostat Vorinostat The risk or severity of QTc prolongation can be increased when Vorinostat is combined with Vandetanib.
Sorafenib Sorafenib The metabolism of Vandetanib can be decreased when combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Vandetanib can be decreased when combined with Sunitinib.
Lapatinib Lapatinib The metabolism of Vandetanib can be decreased when combined with Lapatinib.
Levocetirizine Levocetirizine The risk or severity of QTc prolongation can be increased when Levocetirizine is combined with Vandetanib.
Dasatinib Dasatinib The metabolism of Dasatinib can be decreased when combined with Vandetanib.
Armodafinil Armodafinil The metabolism of Vandetanib can be increased when combined with Armodafinil.
Ivermectin Ivermectin The metabolism of Ivermectin can be increased when combined with Vandetanib.
Temsirolimus Temsirolimus The serum concentration of Temsirolimus can be increased when it is combined with Vandetanib.
Nilotinib Nilotinib The metabolism of Vandetanib can be decreased when combined with Nilotinib.
Toremifene Toremifene The risk or severity of QTc prolongation can be increased when Toremifene is combined with Vandetanib.
Bexarotene Bexarotene The metabolism of Vandetanib can be increased when combined with Bexarotene.
Budesonide Budesonide The metabolism of Vandetanib can be increased when combined with Budesonide.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Vandetanib can be decreased when combined with Chloramphenicol.
Etravirine Etravirine The metabolism of Vandetanib can be increased when combined with Etravirine.
Arsenic Trioxide Injection Arsenic Trioxide Injection The risk or severity of QTc prolongation can be increased when Arsenic trioxide is combined with Vandetanib.
Mitoxantrone Injection Mitoxantrone Injection The metabolism of Mitoxantrone can be decreased when combined with Vandetanib.
Desvenlafaxine Desvenlafaxine The metabolism of Vandetanib can be decreased when combined with Desvenlafaxine.
Bendamustine Injection Bendamustine Injection The serum concentration of Bendamustine can be increased when it is combined with Vandetanib.
Pilocarpine Pilocarpine The metabolism of Vandetanib can be decreased when combined with Pilocarpine.
Flecainide Flecainide The risk or severity of QTc prolongation can be increased when Flecainide is combined with Vandetanib.
Certolizumab Injection Certolizumab Injection The metabolism of Vandetanib can be increased when combined with Certolizumab pegol.
Irinotecan Injection Irinotecan Injection Vandetanib may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Mitotane Mitotane The metabolism of Vandetanib can be increased when combined with Mitotane.
Rufinamide Rufinamide The metabolism of Vandetanib can be increased when combined with Rufinamide.
Silodosin Silodosin The serum concentration of Silodosin can be increased when it is combined with Vandetanib.
Midazolam Midazolam The metabolism of Vandetanib can be decreased when combined with Midazolam.
Milnacipran Milnacipran The metabolism of Vandetanib can be decreased when combined with Milnacipran.
Degarelix Injection Degarelix Injection The risk or severity of QTc prolongation can be increased when Degarelix is combined with Vandetanib.
Betaxolol Betaxolol The risk or severity of QTc prolongation can be increased when Betaxolol is combined with Vandetanib.
Iloperidone Iloperidone The risk or severity of QTc prolongation can be increased when Iloperidone is combined with Vandetanib.
Lacosamide Lacosamide The metabolism of Vandetanib can be decreased when combined with Lacosamide.
Everolimus Everolimus The serum concentration of Everolimus can be increased when it is combined with Vandetanib.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The serum concentration of Tolvaptan can be increased when it is combined with Vandetanib.
Dronedarone Dronedarone Vandetanib may increase the QTc-prolonging activities of Dronedarone.
Pralatrexate Injection Pralatrexate Injection Vandetanib may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Telavancin Injection Telavancin Injection The risk or severity of QTc prolongation can be increased when Telavancin is combined with Vandetanib.
Romidepsin Injection Romidepsin Injection The serum concentration of Romidepsin can be increased when it is combined with Vandetanib.
Topotecan Topotecan The serum concentration of Topotecan can be increased when it is combined with Vandetanib.
Golimumab Injection Golimumab Injection The metabolism of Vandetanib can be increased when combined with Golimumab.
Pazopanib Pazopanib The serum concentration of Pazopanib can be increased when it is combined with Vandetanib.
Asenapine Asenapine The risk or severity of QTc prolongation can be increased when Vandetanib is combined with Asenapine.
Pitavastatin Pitavastatin Vandetanib may decrease the excretion rate of Pitavastatin which could result in a higher serum level.
Albendazole Albendazole The metabolism of Vandetanib can be decreased when combined with Albendazole.
Tocilizumab Injection Tocilizumab Injection The metabolism of Vandetanib can be increased when combined with Tocilizumab.
Dalfampridine Dalfampridine The serum concentration of Dalfampridine can be increased when it is combined with Vandetanib.
Eribulin Injection Eribulin Injection The risk or severity of QTc prolongation can be increased when Eribulin is combined with Vandetanib.
Cabazitaxel Injection Cabazitaxel Injection The serum concentration of Cabazitaxel can be increased when it is combined with Vandetanib.
Lurasidone Lurasidone The risk or severity of QTc prolongation can be increased when Lurasidone is combined with Vandetanib.
Acetaminophen Injection Acetaminophen Injection The metabolism of Acetaminophen can be increased when combined with Vandetanib.
Denileukin Diftitox Injection Denileukin Diftitox Injection The metabolism of Vandetanib can be decreased when combined with Aldesleukin.
Terbutaline Injection Terbutaline Injection The risk or severity of QTc prolongation can be increased when Terbutaline is combined with Vandetanib.
Roflumilast Roflumilast The metabolism of Vandetanib can be decreased when combined with Roflumilast.
Linagliptin Linagliptin The metabolism of Linagliptin can be decreased when combined with Vandetanib.
Rilpivirine Rilpivirine The metabolism of Vandetanib can be decreased when combined with Rilpivirine.
Telaprevir Telaprevir The metabolism of Glecaprevir can be decreased when combined with Vandetanib.
Potassium Iodide Potassium Iodide The therapeutic efficacy of Potassium Iodide can be decreased when used in combination with Vandetanib.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Vandetanib can be increased when combined with Cyclophosphamide.
Triptorelin Injection Triptorelin Injection The risk or severity of QTc prolongation can be increased when Triptorelin is combined with Vandetanib.
Rivaroxaban Rivaroxaban The serum concentration of Rivaroxaban can be increased when it is combined with Vandetanib.
Ticagrelor Ticagrelor The metabolism of Ticagrelor can be decreased when combined with Vandetanib.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The serum concentration of Brentuximab vedotin can be increased when it is combined with Vandetanib.
Clobazam Clobazam The metabolism of Clobazam can be increased when combined with Vandetanib.
Vemurafenib Vemurafenib The metabolism of Vemurafenib can be increased when combined with Vandetanib.
Ivacaftor Ivacaftor The metabolism of Vandetanib can be decreased when combined with Ivacaftor.
Axitinib Axitinib The serum concentration of Axitinib can be increased when it is combined with Vandetanib.
Crizotinib Crizotinib The metabolism of Vandetanib can be decreased when combined with Crizotinib.
Cabergoline Cabergoline The metabolism of Vandetanib can be decreased when combined with Cabergoline.
Naloxone Injection Naloxone Injection The metabolism of Vandetanib can be decreased when combined with Naloxone.
Ambrisentan Ambrisentan The serum concentration of Ambrisentan can be increased when it is combined with Vandetanib.
Carfilzomib Injection Carfilzomib Injection The serum concentration of Carfilzomib can be increased when it is combined with Vandetanib.
Enzalutamide Enzalutamide The metabolism of Vandetanib can be increased when combined with Enzalutamide.
Mirabegron Mirabegron The risk or severity of QTc prolongation can be increased when Mirabegron is combined with Vandetanib.
Regorafenib Regorafenib The metabolism of Vandetanib can be decreased when combined with Regorafenib.
Bosutinib Bosutinib The serum concentration of Bosutinib can be increased when it is combined with Vandetanib.
Corticotropin, Repository Injection Corticotropin, Repository Injection The metabolism of Vandetanib can be increased when combined with Corticotropin.
Teriflunomide Teriflunomide Vandetanib may decrease the excretion rate of Teriflunomide which could result in a higher serum level.
Bedaquiline Bedaquiline The risk or severity of QTc prolongation can be increased when Bedaquiline is combined with Vandetanib.
Ponatinib Ponatinib Vandetanib may decrease the excretion rate of Ponatinib which could result in a higher serum level.
Pomalidomide Pomalidomide The serum concentration of Pomalidomide can be increased when it is combined with Vandetanib.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be decreased when combined with Vandetanib.
Apixaban Apixaban Vandetanib may decrease the excretion rate of Apixaban which could result in a higher serum level.
Canagliflozin Canagliflozin The serum concentration of Canagliflozin can be increased when it is combined with Vandetanib.
Dabrafenib Dabrafenib The metabolism of Vandetanib can be increased when combined with Dabrafenib.
Trametinib Trametinib The metabolism of Vandetanib can be increased when combined with Trametinib.
Dolutegravir Dolutegravir Vandetanib may decrease the excretion rate of Dolutegravir which could result in a higher serum level.
Afatinib Afatinib The serum concentration of Afatinib can be increased when it is combined with Vandetanib.
Perampanel Perampanel The metabolism of Vandetanib can be increased when combined with Perampanel.
Lomitapide Lomitapide The metabolism of Vandetanib can be decreased when combined with Lomitapide.
Simeprevir Simeprevir The metabolism of Simeprevir can be decreased when combined with Vandetanib.
Sofosbuvir Sofosbuvir Vandetanib may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Apremilast Apremilast The metabolism of Vandetanib can be increased when combined with Apremilast.
Ceritinib Ceritinib The metabolism of Vandetanib can be decreased when combined with Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Vandetanib can be increased when combined with Siltuximab.
Eslicarbazepine Eslicarbazepine The metabolism of Vandetanib can be increased when combined with Eslicarbazepine.
Belinostat Injection Belinostat Injection The serum concentration of Belinostat can be increased when it is combined with Vandetanib.
Idelalisib Idelalisib The metabolism of Idelalisib can be decreased when combined with Vandetanib.
Testosterone Injection Testosterone Injection The metabolism of Testosterone can be increased when combined with Vandetanib.
Oritavancin Injection Oritavancin Injection The metabolism of Vandetanib can be increased when combined with Oritavancin.
Vorapaxar Vorapaxar The metabolism of Vandetanib can be decreased when combined with Vorapaxar.
Suvorexant Suvorexant The metabolism of Vandetanib can be decreased when combined with Suvorexant.
Edoxaban Edoxaban The serum concentration of Edoxaban can be increased when it is combined with Vandetanib.
Olaparib Olaparib The metabolism of Vandetanib can be decreased when combined with Olaparib.
Tasimelteon Tasimelteon The metabolism of Vandetanib can be decreased when combined with Tasimelteon.
Riociguat Riociguat Vandetanib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Lanreotide Injection Lanreotide Injection The metabolism of Vandetanib can be decreased when combined with Lanreotide.
Nintedanib Nintedanib The metabolism of Nintedanib can be decreased when combined with Vandetanib.
Secukinumab Injection Secukinumab Injection The metabolism of Vandetanib can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The risk or severity of QTc prolongation can be increased when Risperidone is combined with Vandetanib.
Palbociclib Palbociclib The metabolism of Palbociclib can be decreased when combined with Vandetanib.
Lenvatinib Lenvatinib The metabolism of Vandetanib can be increased when combined with Lenvatinib.
Naloxegol Naloxegol The serum concentration of Naloxegol can be increased when it is combined with Vandetanib.
Panobinostat Panobinostat The serum concentration of Vandetanib can be increased when it is combined with Panobinostat.
Haloperidol Injection Haloperidol Injection The risk or severity of QTc prolongation can be increased when Haloperidol is combined with Vandetanib.
Ivabradine Ivabradine The risk or severity of QTc prolongation can be increased when Vandetanib is combined with Ivabradine.
Isavuconazonium Injection Isavuconazonium Injection The metabolism of Vandetanib can be increased when combined with Isavuconazonium.
Prednisolone Prednisolone The metabolism of Vandetanib can be increased when combined with Prednisolone.
Ziprasidone Injection Ziprasidone Injection The risk or severity of QTc prolongation can be increased when Ziprasidone is combined with Vandetanib.
Cobimetinib Cobimetinib The serum concentration of Cobimetinib can be increased when it is combined with Vandetanib.
Osimertinib Osimertinib The metabolism of Osimertinib can be increased when combined with Vandetanib.
Rifapentine Rifapentine The metabolism of Vandetanib can be increased when combined with Rifapentine.
Lesinurad Lesinurad The metabolism of Vandetanib can be increased when combined with Lesinurad.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The metabolism of Vandetanib can be decreased when combined with Amphotericin B.
Dexamethasone Injection Dexamethasone Injection The metabolism of Vandetanib can be increased when combined with Dexamethasone.
Venetoclax Venetoclax The metabolism of Venetoclax can be decreased when combined with Vandetanib.
Cobicistat Cobicistat The metabolism of Vandetanib can be decreased when combined with Cobicistat.
Selexipag Selexipag The serum concentration of Selexipag can be increased when it is combined with Vandetanib.
Diphenhydramine Injection Diphenhydramine Injection The risk or severity of QTc prolongation can be increased when Diphenhydramine is combined with Vandetanib.
Rucaparib Rucaparib The metabolism of Rucaparib can be decreased when combined with Vandetanib.
Ribociclib Ribociclib The metabolism of Ribociclib can be decreased when combined with Vandetanib.
Parathyroid Hormone Injection Parathyroid Hormone Injection The therapeutic efficacy of Parathyroid hormone can be decreased when used in combination with Vandetanib.
Brigatinib Brigatinib The metabolism of Brigatinib can be increased when combined with Vandetanib.
Doxepin (Insomnia) Doxepin (Insomnia) The risk or severity of QTc prolongation can be increased when Doxepin is combined with Vandetanib.
Deutetrabenazine Deutetrabenazine The risk or severity of QTc prolongation can be increased when Vandetanib is combined with Deutetrabenazine.
Deflazacort Deflazacort The metabolism of Vandetanib can be increased when combined with Deflazacort.
Sarilumab Injection Sarilumab Injection The metabolism of Vandetanib can be increased when combined with Sarilumab.
Midostaurin Midostaurin The metabolism of Vandetanib can be increased when combined with Midostaurin.
Abaloparatide Injection Abaloparatide Injection The therapeutic efficacy of Abaloparatide can be decreased when used in combination with Vandetanib.
Enasidenib Enasidenib The metabolism of Enasidenib can be increased when combined with Vandetanib.
Inotuzumab Ozogamicin Injection Inotuzumab Ozogamicin Injection The serum concentration of Inotuzumab ozogamicin can be increased when it is combined with Vandetanib.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Vandetanib can be increased when combined with Fosaprepitant.
Copanlisib Injection Copanlisib Injection The serum concentration of Copanlisib can be increased when it is combined with Vandetanib.
Delafloxacin Delafloxacin The risk or severity of QTc prolongation can be increased when Delafloxacin is combined with Vandetanib.
Abemaciclib Abemaciclib The serum concentration of Abemaciclib can be increased when it is combined with Vandetanib.
Betrixaban Betrixaban The serum concentration of Betrixaban can be increased when it is combined with Vandetanib.
Acalabrutinib Acalabrutinib The metabolism of Vandetanib can be decreased when combined with Acalabrutinib.
Letermovir Letermovir The metabolism of Vandetanib can be decreased when combined with Letermovir.
Tetrabenazine Tetrabenazine The risk or severity of QTc prolongation can be increased when Tetrabenazine is combined with Vandetanib.
Ertugliflozin Ertugliflozin Vandetanib may decrease the excretion rate of Ertugliflozin which could result in a higher serum level.
Buprenorphine Injection Buprenorphine Injection The metabolism of Vandetanib can be decreased when combined with Buprenorphine.
Apalutamide Apalutamide The metabolism of Vandetanib can be increased when combined with Apalutamide.
Fostamatinib Fostamatinib The metabolism of Vandetanib can be decreased when combined with Fostamatinib.
Avatrombopag Avatrombopag The serum concentration of Avatrombopag can be increased when it is combined with Vandetanib.
Baricitinib Baricitinib The serum concentration of Baricitinib can be increased when it is combined with Vandetanib.
Lofexidine Lofexidine The risk or severity of QTc prolongation can be increased when Lofexidine is combined with Vandetanib.
Eliglustat Eliglustat The risk or severity of QTc prolongation can be increased when Vandetanib is combined with Eliglustat.
Encorafenib Encorafenib The risk or severity of QTc prolongation can be increased when Encorafenib is combined with Vandetanib.
Binimetinib Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Vandetanib.
Ivosidenib Ivosidenib The metabolism of Vandetanib can be increased when combined with Ivosidenib.
Lusutrombopag Lusutrombopag Vandetanib may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Elagolix Elagolix The serum concentration of Elagolix can be increased when it is combined with Vandetanib.
Dacomitinib Dacomitinib The serum concentration of Dacomitinib can be increased when it is combined with Vandetanib.
Duvelisib Duvelisib The metabolism of Duvelisib can be decreased when combined with Vandetanib.
Omadacycline Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Vandetanib.
Stiripentol Stiripentol The metabolism of Vandetanib can be decreased when combined with Stiripentol.
Talazoparib Talazoparib The serum concentration of Talazoparib can be increased when it is combined with Vandetanib.
Gilteritinib Gilteritinib The risk or severity of QTc prolongation can be increased when Gilteritinib is combined with Vandetanib.
Glasdegib Glasdegib The risk or severity of QTc prolongation can be increased when Vandetanib is combined with Glasdegib.
Larotrectinib Larotrectinib The serum concentration of Larotrectinib can be increased when it is combined with Vandetanib.
Methoxy Polyethylene Glycol-Epoetin Beta Injection Methoxy Polyethylene Glycol-Epoetin Beta Injection The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Vandetanib.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Vandetanib can be increased when combined with Paclitaxel.
Rifamycin Rifamycin The metabolism of Rifamycin can be increased when combined with Vandetanib.
Prucalopride Prucalopride The serum concentration of Prucalopride can be increased when it is combined with Vandetanib.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Vandetanib can be increased when combined with Emapalumab.
Siponimod Siponimod The metabolism of Vandetanib can be decreased when combined with Siponimod.
Alpelisib Alpelisib The serum concentration of Alpelisib can be increased when it is combined with Vandetanib.
Cladribine Cladribine Vandetanib may decrease the excretion rate of Cladribine which could result in a higher serum level.
Solriamfetol Solriamfetol The serum concentration of Solriamfetol can be increased when it is combined with Vandetanib.
Darolutamide Darolutamide Vandetanib may decrease the excretion rate of Darolutamide which could result in a higher serum level.
Triclabendazole Triclabendazole The metabolism of Vandetanib can be decreased when combined with Triclabendazole.
Entrectinib Entrectinib The risk or severity of QTc prolongation can be increased when Vandetanib is combined with Entrectinib.
Pitolisant Pitolisant The serum concentration of Vandetanib can be decreased when it is combined with Pitolisant.
Fedratinib Fedratinib The serum concentration of Fedratinib can be increased when it is combined with Vandetanib.
Lefamulin Lefamulin Vandetanib may increase the QTc-prolonging activities of Lefamulin.
Phenytoin Injection Phenytoin Injection The metabolism of Vandetanib can be increased when combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Vandetanib can be increased when combined with Fosphenytoin.
Enfortumab vedotin-ejfv Injection Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be increased when it is combined with Vandetanib.
Voxelotor Voxelotor The serum concentration of Vandetanib can be increased when it is combined with Voxelotor.
Lasmiditan Lasmiditan The serum concentration of Lasmiditan can be increased when it is combined with Vandetanib.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Vandetanib.
Tazemetostat Tazemetostat The metabolism of Tazemetostat can be decreased when combined with Vandetanib.
Cenobamate Cenobamate The serum concentration of Vandetanib can be decreased when it is combined with Cenobamate.
Ozanimod Ozanimod Vandetanib may decrease the excretion rate of Ozanimod which could result in a higher serum level.
Selumetinib Selumetinib Vandetanib may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Rimegepant Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Vandetanib.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Vandetanib.
Remdesivir Injection Remdesivir Injection The serum concentration of Remdesivir can be increased when it is combined with Vandetanib.
Ripretinib Ripretinib Vandetanib may decrease the excretion rate of Ripretinib which could result in a higher serum level.
Lemborexant Lemborexant The serum concentration of Lemborexant can be increased when it is combined with Vandetanib.
Fostemsavir Fostemsavir The risk or severity of QTc prolongation can be increased when Fostemsavir is combined with Vandetanib.
Octreotide Octreotide The serum concentration of Vandetanib can be increased when it is combined with Octreotide.
Belantamab Mafodotin-blmf Injection Belantamab Mafodotin-blmf Injection The serum concentration of Belantamab mafodotin can be increased when it is combined with Vandetanib.
Pralsetinib Pralsetinib The serum concentration of Pralsetinib can be increased when it is combined with Vandetanib.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Vandetanib can be decreased when it is combined with Satralizumab.
Relugolix Relugolix The serum concentration of Relugolix can be increased when it is combined with Vandetanib.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Vandetanib can be decreased when combined with Drospirenone.
Vitamin E (Alpha-Tocopherol) Vitamin E (Alpha-Tocopherol) The metabolism of Vandetanib can be increased when combined with Vitamin E.
Trazodone Trazodone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Vandetanib.
Phenobarbital Phenobarbital The metabolism of Vandetanib can be increased when combined with Phenobarbital.
Methotrexate Injection Methotrexate Injection Vandetanib may decrease the excretion rate of Methotrexate which could result in a higher serum level.
Primidone Primidone The metabolism of Vandetanib can be increased when combined with Primidone.
Methsuximide Methsuximide The risk or severity of QTc prolongation can be increased when Methsuximide is combined with Vandetanib.
Chlorpromazine Chlorpromazine The metabolism of Vandetanib can be increased when combined with Chlorpromazine.
Diazepam Diazepam The metabolism of Vandetanib can be decreased when combined with Diazepam.
Lorazepam Lorazepam The metabolism of Vandetanib can be decreased when combined with Lorazepam.
Amantadine Amantadine The risk or severity of QTc prolongation can be increased when Amantadine is combined with Vandetanib.
Bromocriptine Bromocriptine The metabolism of Vandetanib can be decreased when combined with Bromocriptine.
Tranylcypromine Tranylcypromine The metabolism of Vandetanib can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine The metabolism of Vandetanib can be decreased when combined with Phenelzine.
Tetracycline Tetracycline The metabolism of Vandetanib can be decreased when combined with Tetracycline.
Prochlorperazine Prochlorperazine The risk or severity of QTc prolongation can be increased when Prochlorperazine is combined with Vandetanib.
Thioridazine Thioridazine The risk or severity of QTc prolongation can be increased when Thioridazine is combined with Vandetanib.
Methadone Methadone The metabolism of Vandetanib can be increased when combined with Methadone.
Oxybutynin Oxybutynin The metabolism of Vandetanib can be decreased when combined with Oxybutynin.
Benztropine Benztropine The risk or severity of QTc prolongation can be increased when Benzatropine is combined with Vandetanib.
Maprotiline Maprotiline The risk or severity of QTc prolongation can be increased when Maprotiline is combined with Vandetanib.
Orphenadrine Orphenadrine The metabolism of Vandetanib can be decreased when combined with Orphenadrine.
Phentermine Phentermine The metabolism of Vandetanib can be decreased when combined with Phentermine.
Amoxapine Amoxapine The risk or severity of QTc prolongation can be increased when Amoxapine is combined with Vandetanib.
Sulfasalazine Sulfasalazine Vandetanib may decrease the excretion rate of Sulfasalazine which could result in a higher serum level.
Hydrocortisone Hydrocortisone The metabolism of Vandetanib can be increased when combined with Hydrocortisone.
Doxorubicin Doxorubicin The serum concentration of Doxorubicin can be increased when it is combined with Vandetanib.
Dactinomycin Dactinomycin The serum concentration of Dactinomycin can be increased when it is combined with Vandetanib.
Carbamazepine Carbamazepine The metabolism of Vandetanib can be increased when combined with Carbamazepine.
Prazosin Prazosin Vandetanib may decrease the excretion rate of Prazosin which could result in a higher serum level.
Hydralazine Hydralazine The metabolism of Vandetanib can be decreased when combined with Hydralazine.
Cimetidine Cimetidine The metabolism of Cimetidine can be decreased when combined with Vandetanib.
Warfarin Warfarin The metabolism of Vandetanib can be increased when combined with Warfarin.
Loperamide Loperamide The metabolism of Vandetanib can be decreased when combined with Loperamide.
Promethazine Promethazine The risk or severity of QTc prolongation can be increased when Promethazine is combined with Vandetanib.
Daunorubicin Daunorubicin The metabolism of Daunorubicin can be decreased when combined with Vandetanib.
Nitrofurantoin Nitrofurantoin Vandetanib may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Griseofulvin Griseofulvin The metabolism of Vandetanib can be increased when combined with Griseofulvin.
Digoxin Digoxin Vandetanib may decrease the excretion rate of Digoxin which could result in a higher serum level.
Chloroquine Chloroquine The risk or severity of QTc prolongation can be increased when Chloroquine is combined with Vandetanib.
Quinine Quinine The metabolism of Vandetanib can be increased when combined with Quinine.
Ethosuximide Ethosuximide The risk or severity of QTc prolongation can be increased when Ethosuximide is combined with Vandetanib.
Calcitriol Calcitriol The metabolism of Vandetanib can be increased when combined with Calcitriol.
Sulfinpyrazone Sulfinpyrazone The metabolism of Vandetanib can be increased when combined with Sulfinpyrazone.
Secobarbital Secobarbital The metabolism of Vandetanib can be increased when combined with Secobarbital.
Desipramine Desipramine The metabolism of Vandetanib can be decreased when combined with Desipramine.
Amitriptyline Amitriptyline The risk or severity of QTc prolongation can be increased when Amitriptyline is combined with Vandetanib.
Imipramine Imipramine The serum concentration of Vandetanib can be increased when it is combined with Imipramine.
Probenecid Probenecid The metabolism of Vandetanib can be increased when combined with Probenecid.
Quinidine Quinidine The serum concentration of Quinidine can be increased when it is combined with Vandetanib.
Procainamide Procainamide The risk or severity of QTc prolongation can be increased when Procainamide is combined with Vandetanib.
Isoniazid Isoniazid The metabolism of Vandetanib can be decreased when combined with Isoniazid.
Rifampin Rifampin The metabolism of Vandetanib can be increased when combined with Rifampicin.
Disopyramide Disopyramide The risk or severity of QTc prolongation can be increased when Disopyramide is combined with Vandetanib.
Valproic Acid Valproic Acid The metabolism of Vandetanib can be decreased when combined with Valproic acid.
Tamoxifen Tamoxifen The metabolism of Vandetanib can be increased when combined with Tamoxifen.
Levothyroxine Levothyroxine The therapeutic efficacy of Levothyroxine can be decreased when used in combination with Vandetanib.
Liothyronine Liothyronine The therapeutic efficacy of Liothyronine can be decreased when used in combination with Vandetanib.
Methimazole Methimazole The therapeutic efficacy of Methimazole can be decreased when used in combination with Vandetanib.
Propylthiouracil Propylthiouracil The therapeutic efficacy of Propylthiouracil can be decreased when used in combination with Vandetanib.
Niacin Niacin The metabolism of Vandetanib can be decreased when combined with Niacin.
Doxylamine Doxylamine The risk or severity of QTc prolongation can be increased when Doxylamine is combined with Vandetanib.
Cyproheptadine Cyproheptadine The risk or severity of QTc prolongation can be increased when Cyproheptadine is combined with Vandetanib.
Clemastine Clemastine The risk or severity of QTc prolongation can be increased when Clemastine is combined with Vandetanib.
Chlorpheniramine Chlorpheniramine The risk or severity of QTc prolongation can be increased when Chlorpheniramine is combined with Vandetanib.
Brompheniramine Brompheniramine The risk or severity of QTc prolongation can be increased when Dexbrompheniramine is combined with Vandetanib.
Hydrochlorothiazide Hydrochlorothiazide The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Vandetanib.
Folic Acid Folic Acid Vandetanib may decrease the excretion rate of Folic acid which could result in a higher serum level.
Danazol Danazol The metabolism of Vandetanib can be decreased when combined with Danazol.
Disulfiram Disulfiram The risk or severity of QTc prolongation can be increased when Disulfiram is combined with Vandetanib.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The risk or severity of QTc prolongation can be increased when Propranolol is combined with Vandetanib.
Nortriptyline Nortriptyline The serum concentration of Vandetanib can be increased when it is combined with Nortriptyline.
Amphotericin B Injection Amphotericin B Injection The metabolism of Vandetanib can be decreased when combined with Amphotericin B.
Allopurinol Allopurinol Vandetanib may decrease the excretion rate of Allopurinol which could result in a higher serum level.
Oxytocin Injection Oxytocin Injection The risk or severity of QTc prolongation can be increased when Oxytocin is combined with Vandetanib.
Clomiphene Clomiphene The serum concentration of Clomifene can be increased when it is combined with Vandetanib.
Papaverine Papaverine The risk or severity of QTc prolongation can be increased when Papaverine is combined with Vandetanib.
Fluorouracil Injection Fluorouracil Injection The risk or severity of QTc prolongation can be increased when Fluorouracil is combined with Vandetanib.
Colchicine Colchicine The serum concentration of Colchicine can be increased when it is combined with Vandetanib.
Cephalexin Cephalexin The metabolism of Vandetanib can be decreased when combined with Cephalexin.
Acetazolamide Acetazolamide The metabolism of Vandetanib can be decreased when combined with Acetazolamide.
Calcitonin Salmon Injection Calcitonin Salmon Injection The therapeutic efficacy of Salmon calcitonin can be decreased when used in combination with Vandetanib.
Ketoconazole Ketoconazole The metabolism of Vandetanib can be decreased when combined with Ketoconazole.
Vincristine Injection Vincristine Injection The excretion of Vincristine can be decreased when combined with Vandetanib.
Vinblastine Vinblastine The metabolism of Vinblastine can be increased when combined with Vandetanib.
Metoprolol Metoprolol The metabolism of Vandetanib can be decreased when combined with Metoprolol.
Hydroxyzine Hydroxyzine The risk or severity of QTc prolongation can be increased when Hydroxyzine is combined with Vandetanib.
Thiothixene Thiothixene The risk or severity of QTc prolongation can be increased when Thiothixene is combined with Vandetanib.
Hyoscyamine Hyoscyamine The risk or severity of QTc prolongation can be increased when Hyoscyamine is combined with Vandetanib.
Diltiazem Diltiazem The metabolism of Vandetanib can be decreased when combined with Diltiazem.
Nifedipine Nifedipine The metabolism of Vandetanib can be increased when combined with Nifedipine.
Timolol Timolol The risk or severity of QTc prolongation can be increased when Timolol is combined with Vandetanib.
Verapamil Verapamil The metabolism of Vandetanib can be decreased when combined with Verapamil.
Cisplatin Injection Cisplatin Injection The serum concentration of Cisplatin can be increased when it is combined with Vandetanib.
Etoposide Etoposide The metabolism of Etoposide can be increased when combined with Vandetanib.
Glyburide Glyburide The metabolism of Glyburide can be decreased when combined with Vandetanib.
Indapamide Indapamide The risk or severity of QTc prolongation can be increased when Indapamide is combined with Vandetanib.
Dicloxacillin Dicloxacillin The metabolism of Vandetanib can be increased when combined with Dicloxacillin.
Nafcillin Injection Nafcillin Injection The metabolism of Vandetanib can be increased when combined with Nafcillin.
Pentamidine Injection Pentamidine Injection The risk or severity of QTc prolongation can be increased when Pentamidine is combined with Vandetanib.
Leuprolide Injection Leuprolide Injection The risk or severity of QTc prolongation can be increased when Leuprolide is combined with Vandetanib.
Pimozide Pimozide The metabolism of Vandetanib can be decreased when combined with Pimozide.
Amiodarone Amiodarone The metabolism of Vandetanib can be decreased when combined with Amiodarone.
Lovastatin Lovastatin The metabolism of Vandetanib can be decreased when combined with Lovastatin.
Ciprofloxacin Ciprofloxacin The metabolism of Vandetanib can be decreased when combined with Ciprofloxacin.
Fluoxetine Fluoxetine The risk or severity of QTc prolongation can be increased when Fluoxetine is combined with Vandetanib.
Nimodipine Nimodipine The risk or severity of QTc prolongation can be increased when Nimodipine is combined with Vandetanib.
Clozapine Clozapine The metabolism of Vandetanib can be increased when combined with Clozapine.
Ofloxacin Ofloxacin The risk or severity of QTc prolongation can be increased when Ofloxacin is combined with Vandetanib.
Clarithromycin Clarithromycin The metabolism of Vandetanib can be decreased when combined with Clarithromycin.
Felodipine Felodipine The metabolism of Vandetanib can be decreased when combined with Felodipine.
Pravastatin Pravastatin Vandetanib may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Simvastatin Simvastatin The serum concentration of Simvastatin can be increased when it is combined with Vandetanib.
Epoetin Alfa, Injection Epoetin Alfa, Injection The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Vandetanib.
Teniposide Injection Teniposide Injection The metabolism of Teniposide can be decreased when combined with Vandetanib.
Itraconazole Itraconazole The metabolism of Vandetanib can be decreased when combined with Itraconazole.
Rifabutin Rifabutin The metabolism of Vandetanib can be increased when combined with Rifabutin.
Sotalol Sotalol The risk or severity of QTc prolongation can be increased when Sotalol is combined with Vandetanib.
Bisoprolol Bisoprolol The serum concentration of Bisoprolol can be increased when it is combined with Vandetanib.
Doxazosin Doxazosin The metabolism of Vandetanib can be decreased when combined with Doxazosin.
Isradipine Isradipine The metabolism of Vandetanib can be decreased when combined with Isradipine.
Omeprazole Omeprazole The metabolism of Vandetanib can be increased when combined with Omeprazole.
Cisapride Cisapride The risk or severity of QTc prolongation can be increased when Cisapride is combined with Vandetanib.
Fluvastatin Fluvastatin The metabolism of Vandetanib can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine The risk or severity of QTc prolongation can be increased when Venlafaxine is combined with Vandetanib.
Famciclovir Famciclovir The metabolism of Vandetanib can be decreased when combined with Famciclovir.
Fluvoxamine Fluvoxamine The metabolism of Vandetanib can be decreased when combined with Fluvoxamine.
Nefazodone Nefazodone The metabolism of Vandetanib can be decreased when combined with Nefazodone.
Lamotrigine Lamotrigine The risk or severity of QTc prolongation can be increased when Lamotrigine is combined with Vandetanib.
Losartan Losartan The metabolism of Vandetanib can be decreased when combined with Losartan.
Moexipril Moexipril The risk or severity of QTc prolongation can be increased when Moexipril is combined with Vandetanib.
Lansoprazole Lansoprazole The metabolism of Vandetanib can be increased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The metabolism of Vandetanib can be increased when combined with Ifosfamide.
Nicardipine Nicardipine The metabolism of Vandetanib can be decreased when combined with Nicardipine.
Ticlopidine Ticlopidine The metabolism of Vandetanib can be decreased when combined with Ticlopidine.
Saquinavir Saquinavir The metabolism of Saquinavir can be decreased when combined with Vandetanib.
Metformin Metformin The serum concentration of Metformin can be increased when it is combined with Vandetanib.
Lamivudine Lamivudine Vandetanib may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Riluzole Riluzole Vandetanib may decrease the excretion rate of Riluzole which could result in a higher serum level.
Gemcitabine Injection Gemcitabine Injection The serum concentration of Gemcitabine can be increased when it is combined with Vandetanib.
Ritonavir Ritonavir The serum concentration of Vandetanib can be increased when it is combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Vandetanib can be decreased when combined with Docetaxel.
Clomipramine Clomipramine The risk or severity of QTc prolongation can be increased when Clomipramine is combined with Vandetanib.
Zafirlukast Zafirlukast The metabolism of Vandetanib can be decreased when combined with Zafirlukast.
Mirtazapine Mirtazapine The metabolism of Vandetanib can be decreased when combined with Mirtazapine.
Topiramate Topiramate The metabolism of Vandetanib can be increased when combined with Topiramate.
Pramipexole Pramipexole The serum concentration of Pramipexole can be increased when it is combined with Vandetanib.
Donepezil Donepezil Vandetanib may decrease the excretion rate of Donepezil which could result in a higher serum level.
Nelfinavir Nelfinavir The risk or severity of QTc prolongation can be increased when Nelfinavir is combined with Vandetanib.
Fexofenadine Fexofenadine The serum concentration of Vandetanib can be increased when it is combined with Fexofenadine.
Azithromycin Azithromycin The risk or severity of QTc prolongation can be increased when Azithromycin is combined with Vandetanib.
Bicalutamide Bicalutamide The metabolism of Vandetanib can be decreased when combined with Bicalutamide.
Propafenone Propafenone The risk or severity of QTc prolongation can be increased when Propafenone is combined with Vandetanib.
Raloxifene Raloxifene The metabolism of Raloxifene can be decreased when combined with Vandetanib.
Irbesartan Irbesartan The metabolism of Vandetanib can be decreased when combined with Irbesartan.
Quetiapine Quetiapine The risk or severity of QTc prolongation can be increased when Vandetanib is combined with Quetiapine.
Cetirizine Cetirizine The risk or severity of QTc prolongation can be increased when Cetirizine is combined with Vandetanib.
Paroxetine Paroxetine The metabolism of Vandetanib can be decreased when combined with Paroxetine.
Citalopram Citalopram The metabolism of Vandetanib can be decreased when combined with Citalopram.
Efavirenz Efavirenz The metabolism of Vandetanib can be increased when combined with Efavirenz.
Sildenafil Sildenafil The serum concentration of Sildenafil can be increased when it is combined with Vandetanib.
Celecoxib Celecoxib Vandetanib may decrease the excretion rate of Celecoxib which could result in a higher serum level.
Tolterodine Tolterodine The risk or severity of QTc prolongation can be increased when Tolterodine is combined with Vandetanib.
Galantamine Galantamine The risk or severity of QTc prolongation can be increased when Galantamine is combined with Vandetanib.
Rabeprazole Rabeprazole The metabolism of Vandetanib can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Vandetanib can be increased when combined with Terbinafine.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists

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