Humann Superbeets Heart Chews - Sylvant (Siltuximab) Interaction
Herbal: Humann Superbeets Heart Chews
Drug: Siltuximab
Brand names:
Sylvant
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Nov 23, 2023
Interaction Details
Siltuximab is classified as belonging to the following category: Cytochrome P450 3A4 (Cyp3A4) Substrates
Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews). Laboratory studies suggest that grape seed extract might have inhibitory effects on the CYP3A4 metabolizing enzyme. If this enzyme is inhibited, drugs metabolized by it may undergo slower metabolism, potentially leading to (in many cases) higher-than-normal drug levels. Elevated drug levels can increase the risk of experiencing side effects. However, it's important to point out that there is no documented or reported instance of this specific interaction occurring in human studies.
Interaction Rating
Likelihood of Occurrence
UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Pharmacist Analysis
It is unlikely that grape seed extracts have a clinically significant interaction with drugs that are metabolized by CYP3A4. This effect has only been seen in lab studies and has not been seen in human ones.
Nevertheless, it may be worthwhile to know if the drug you are taking (such as the one in this interaction detail page) is metabolized by CYP3A4 and monitor yourself accordingly.
References
- An in vitro evaluation of cytochrome P450 inhibition and P-glycoprotein interaction with goldenseal, Ginkgo biloba, grape seed, milk thistle, and ginseng extracts and their constituents. PubMed
- Effects of continuous ingestion of green tea or grape seed extracts on the pharmacokinetics of midazolam. PubMed
Humann Superbeets Heart Chews Overview
HumanN SuperBeets Heart Chews is a dietary supplement that aims to support heart health in a convenient chewable form. The chews include two herbal ingredients: beetroot powder and a proprietary grape seed extract known as Enovita. Beetroot powder provides, among other things, dietary nitrates, which can convert into nitric oxide in the body, supporting healthy blood flow and cardiovascular function. The grape seed extract, Enovita, is a proprietary formulation rich in proanthocyanidins (OPCs) sourced exclusively from grape seeds used in white wine production. OPCs are antioxidants known for potential benefits in promoting heart health and protecting against oxidative stress.
Siltuximab Overview
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Siltuximab injection is used to treat multicentric Castleman's disease (MCD; abnormal overgrowth of lymph cells in more than one part of the body that may cause symptoms and may increase the risk of developing a serious infection or cancer) in people who do not have human immunodeficiency virus (HIV) and human herpesvirus-8 (HHV-8) infection. Siltuximab is in a class of medications called monoclonal antibodies. It works by blocking the action of a natural substance that causes increased growth of lymph cells in people with MCD.
Humann Superbeets Heart Chews - More Interactions
Humann Superbeets Heart Chews interacts with 870 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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