Siltuximab Injection drug information

Why is this medication prescribed?
How should this medicine be used?
Other uses for this medicine
What special precautions should I follow?
What special dietary instructions should I follow?
What should I do if I forget a dose?
What side effects can this medication cause?
What should I do in case of OVERDOSE?
What OTHER INFORMATION should I know?
Drug interactions

Why is this medication prescribed?

Siltuximab injection is used to treat multicentric Castleman's disease (MCD; abnormal overgrowth of lymph cells in more than one part of the body that may cause symptoms and may increase the risk of developing a serious infection or cancer) in people who do not have human immunodeficiency virus (HIV) and human herpesvirus-8 (HHV-8) infection. Siltuximab is in a class of medications called monoclonal antibodies. It works by blocking the action of a natural substance that causes increased growth of lymph cells in people with MCD.

How should this medicine be used?

Siltuximab injection comes as a liquid to be injected intravenously (into a vein) over 1 hour by a healthcare provider in a hospital or medical office. It is usually given once every 3 weeks.

You may experience a reaction when you receive siltuximab injection. If you experience a reaction, your healthcare provider will stop your infusion and will give you medication to treat your reaction. If your reaction is severe, your healthcare provider may not give you any more infusions of siltuximab. Tell your healthcare provider or get emergency medical treatment if you experience any of the following symptoms during or after your infusion: trouble breathing; chest tightness; wheezing; dizziness or light-headedness; swelling of the face, lips, tongue or throat; rash; itching; headache; back pain; chest pain; nausea; vomiting; flushing; reddening of the skin; or pounding heartbeat.

Siltuximab injection may help to control MCD but does not cure it. Continue to keep appointments to receive siltuximab injection even if you feel well.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before receiving siltuximab injection,

tell your doctor and pharmacist if you are allergic to siltuximab injection, any other medications, or any of the ingredients in siltuximab injection. Ask your pharmacist or check the manufacturer's patient information for a list of the ingredients.

tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven), atorvastatin (Lipitor), cyclosporine (Gengraf, Neoral, Sandimmune), lovastatin (in Altoprev), oral contraceptives (birth control pills), and theophylline ( Theo-24, Uniphyl). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

tell your doctor if you have any type of infection before you begin your treatment with siltuximab injection, or if you notice any signs of infection during your treatment. Also tell your doctor if you have or have ever had any condition that affects your stomach or intestines such as ulcers (sores in the lining of the stomach or intestines) or diverticulitis (small pouches in the lining of the intestine that may become inflamed).

tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. You should use birth control to prevent pregnancy during your treatment with siltuximab injection and for three months after your treatment. Talk to your doctor about methods of birth control that will work for you. If you become pregnant while receiving siltuximab injection, call your doctor immediately. Siltuximab may harm the fetus.

do not have any vaccinations without talking to your doctor. Also tell your doctor if you have recently received any vaccinations. Talk to your doctor about whether you should receive any vaccinations before you begin your treatment.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do if I forget a dose?

If you miss an appointment to receive a dose of siltuximab injection, call your doctor as soon as possible.

What side effects can this medication cause?

Siltuximab injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- darkening of the skin
- dry skin
- constipation
- mouth or throat pain
- weight gain

Some side effects can be serious. If you experience any of these symptoms or those in the HOW section, call your doctor immediately or get emergency medical treatment:
- fever, sore throat, chills, or other signs of infection
- unusual bruising or bleeding
- swelling of the hands, arms, feet, ankles, or lower legs
Siltuximab injection may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What should I do in case of OVERDOSE?

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

What OTHER INFORMATION should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to siltuximab injection.

Ask your pharmacist any questions you have about siltuximab injection.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug interactions

Drug	Interaction
Repaglinide	Repaglinide The metabolism of Repaglinide can be increased when combined with Siltuximab.
Montelukast	Montelukast The metabolism of Montelukast can be increased when combined with Siltuximab.
Leflunomide	Leflunomide The risk or severity of adverse effects can be increased when Siltuximab is combined with Leflunomide.
Delavirdine	Delavirdine The metabolism of Delavirdine can be increased when combined with Siltuximab.
Nevirapine	Nevirapine The metabolism of Nevirapine can be increased when combined with Siltuximab.
Atorvastatin	Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Siltuximab.
Dolasetron	Dolasetron The metabolism of Dolasetron can be increased when combined with Siltuximab.
Aminophylline	Aminophylline The metabolism of Aminophylline can be increased when combined with Siltuximab.
Anagrelide	Anagrelide The metabolism of Anagrelide can be increased when combined with Siltuximab.
Candesartan	Candesartan The metabolism of Candesartan can be increased when combined with Siltuximab.
Cilostazol	Cilostazol The metabolism of Cilostazol can be decreased when combined with Siltuximab.
Clopidogrel	Clopidogrel The metabolism of Clopidogrel can be increased when combined with Siltuximab.
Erythromycin and Sulfisoxazole	Erythromycin and Sulfisoxazole The metabolism of Erythromycin can be increased when combined with Siltuximab.
Estrogen and Progestin (Oral Contraceptives)	Estrogen and Progestin (Oral Contraceptives) The metabolism of Conjugated estrogens can be increased when combined with Siltuximab.
Fenofibrate	Fenofibrate The metabolism of Fenofibrate can be increased when combined with Siltuximab.
Mycophenolate	Mycophenolate The risk or severity of adverse effects can be increased when Mycophenolic acid is combined with Siltuximab.
Paregoric	Paregoric The metabolism of Morphine can be increased when combined with Siltuximab.
Penbutolol	Penbutolol The metabolism of Acebutolol can be increased when combined with Siltuximab.
Prednisone	Prednisone The risk or severity of adverse effects can be increased when Prednisone is combined with Siltuximab.
Ranitidine	Ranitidine The metabolism of Ranitidine can be increased when combined with Siltuximab.
Tacrolimus	Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Siltuximab.
Tizanidine	Tizanidine The metabolism of Tizanidine can be increased when combined with Siltuximab.
Triamcinolone	Triamcinolone The metabolism of Triamcinolone can be increased when combined with Siltuximab.
Zolmitriptan	Zolmitriptan The metabolism of Zolmitriptan can be increased when combined with Siltuximab.
Hydromorphone Injection	Hydromorphone Injection The metabolism of Hydromorphone can be increased when combined with Siltuximab.
Interferon Beta-1b Injection	Interferon Beta-1b Injection The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Siltuximab.
Interferon Gamma-1b Injection	Interferon Gamma-1b Injection The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Siltuximab.
Meperidine Injection	Meperidine Injection The metabolism of Meperidine can be increased when combined with Siltuximab.
Methylprednisolone Injection	Methylprednisolone Injection The risk or severity of adverse effects can be increased when Methylprednisolone is combined with Siltuximab.
Metoclopramide Injection	Metoclopramide Injection The metabolism of Metoclopramide can be increased when combined with Siltuximab.
Metronidazole Injection	Metronidazole Injection The metabolism of Metronidazole can be increased when combined with Siltuximab.
Morphine Injection	Morphine Injection The metabolism of Morphine can be increased when combined with Siltuximab.
Zidovudine Injection	Zidovudine Injection The metabolism of Zidovudine can be increased when combined with Siltuximab.
Altretamine	Altretamine The metabolism of Amphetamine can be increased when combined with Siltuximab.
Cyclosporine	Cyclosporine Siltuximab may increase the immunosuppressive activities of Cyclosporine.
Ondansetron	Ondansetron The metabolism of Ondansetron can be increased when combined with Siltuximab.
Torsemide	Torsemide The metabolism of Torasemide can be increased when combined with Siltuximab.
Olanzapine	Olanzapine The metabolism of Olanzapine can be increased when combined with Siltuximab.
Alosetron	Alosetron The metabolism of Alosetron can be increased when combined with Siltuximab.
Dofetilide	Dofetilide The metabolism of Dofetilide can be increased when combined with Siltuximab.
Hydroxychloroquine	Hydroxychloroquine The metabolism of Siltuximab can be increased when combined with Hydroxychloroquine.
Meloxicam	Meloxicam The metabolism of Meloxicam can be increased when combined with Siltuximab.
Pantoprazole	Pantoprazole The metabolism of Pantoprazole can be increased when combined with Siltuximab.
Temozolomide	Temozolomide The risk or severity of adverse effects can be increased when Temozolomide is combined with Siltuximab.
Zaleplon	Zaleplon The metabolism of Zaleplon can be increased when combined with Siltuximab.
Anakinra	Anakinra The risk or severity of adverse effects can be increased when Anakinra is combined with Siltuximab.
Linezolid	Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Siltuximab.
Trimipramine	Trimipramine The metabolism of Trimipramine can be increased when combined with Siltuximab.
Etanercept Injection	Etanercept Injection The risk or severity of adverse effects can be increased when Etanercept is combined with Siltuximab.
Tenofovir	Tenofovir The metabolism of Tenofovir can be increased when combined with Siltuximab.
Sirolimus	Sirolimus The metabolism of Sirolimus can be increased when combined with Siltuximab.
Dutasteride	Dutasteride The metabolism of Dutasteride can be increased when combined with Siltuximab.
Epirubicin	Epirubicin The risk or severity of adverse effects can be increased when Epirubicin is combined with Siltuximab.
Eplerenone	Eplerenone The metabolism of Eplerenone can be increased when combined with Siltuximab.
Escitalopram	Escitalopram The metabolism of Escitalopram can be increased when combined with Siltuximab.
Zonisamide	Zonisamide The metabolism of Zonisamide can be increased when combined with Siltuximab.
Adalimumab Injection	Adalimumab Injection The risk or severity of adverse effects can be increased when Adalimumab is combined with Siltuximab.
Aripiprazole	Aripiprazole The metabolism of Aripiprazole can be increased when combined with Siltuximab.
Atomoxetine	Atomoxetine The metabolism of Atomoxetine can be increased when combined with Siltuximab.
Glatiramer Injection	Glatiramer Injection The risk or severity of adverse effects can be increased when Glatiramer is combined with Siltuximab.
Atazanavir	Atazanavir The metabolism of Atazanavir can be increased when combined with Siltuximab.
Almotriptan	Almotriptan The metabolism of Almotriptan can be increased when combined with Siltuximab.
Eletriptan	Eletriptan The metabolism of Eletriptan can be increased when combined with Siltuximab.
Omalizumab Injection	Omalizumab Injection The risk or severity of adverse effects can be increased when Omalizumab is combined with Siltuximab.
Rosuvastatin	Rosuvastatin The metabolism of Rosuvastatin can be increased when combined with Siltuximab.
Vardenafil	Vardenafil The metabolism of Vardenafil can be decreased when combined with Siltuximab.
Alfuzosin	Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Siltuximab.
Aprepitant	Aprepitant The metabolism of Aprepitant can be increased when combined with Siltuximab.
Tegaserod	Tegaserod The metabolism of Tegaserod can be increased when combined with Siltuximab.
Tadalafil	Tadalafil The metabolism of Tadalafil can be increased when combined with Siltuximab.
Frovatriptan	Frovatriptan The metabolism of Frovatriptan can be increased when combined with Siltuximab.
Progesterone	Progesterone The metabolism of Progesterone can be increased when combined with Siltuximab.
Apomorphine Injection	Apomorphine Injection The metabolism of Apomorphine can be increased when combined with Siltuximab.
Darbepoetin Alfa Injection	Darbepoetin Alfa Injection The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Siltuximab.
Infliximab Injection	Infliximab Injection The risk or severity of adverse effects can be increased when Infliximab is combined with Siltuximab.
Protriptyline	Protriptyline The metabolism of Protriptyline can be increased when combined with Siltuximab.
Duloxetine	Duloxetine The metabolism of Duloxetine can be increased when combined with Siltuximab.
Norethindrone	Norethindrone The metabolism of Norethisterone can be increased when combined with Siltuximab.
Bosentan	Bosentan The metabolism of Bosentan can be increased when combined with Siltuximab.
Cinacalcet	Cinacalcet The metabolism of Cinacalcet can be increased when combined with Siltuximab.
Natalizumab Injection	Natalizumab Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Natalizumab.
Erlotinib	Erlotinib The serum concentration of Erlotinib can be decreased when it is combined with Siltuximab.
Eszopiclone	Eszopiclone The serum concentration of Eszopiclone can be decreased when it is combined with Siltuximab.
Solifenacin	Solifenacin The metabolism of Solifenacin can be increased when combined with Siltuximab.
Voriconazole	Voriconazole The metabolism of Voriconazole can be increased when combined with Siltuximab.
Dextroamphetamine	Dextroamphetamine The metabolism of Amphetamine can be increased when combined with Siltuximab.
Entecavir	Entecavir The metabolism of Entecavir can be increased when combined with Siltuximab.
Peginterferon Alfa-2a Injection	Peginterferon Alfa-2a Injection The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Siltuximab.
Peginterferon Alfa-2b (PEG-Intron)	Peginterferon Alfa-2b (PEG-Intron) The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Siltuximab.
Ramelteon	Ramelteon The metabolism of Ramelteon can be increased when combined with Siltuximab.
Darifenacin	Darifenacin The metabolism of Darifenacin can be increased when combined with Siltuximab.
Fentanyl	Fentanyl The metabolism of Fentanyl can be decreased when combined with Siltuximab.
Tipranavir	Tipranavir The metabolism of Tipranavir can be increased when combined with Siltuximab.
Felbamate	Felbamate The metabolism of Felbamate can be increased when combined with Siltuximab.
Ranolazine	Ranolazine The metabolism of Ranolazine can be increased when combined with Siltuximab.
Abatacept Injection	Abatacept Injection The risk or severity of adverse effects can be increased when Abatacept is combined with Siltuximab.
Rasagiline	Rasagiline The metabolism of Rasagiline can be increased when combined with Siltuximab.
Imatinib	Imatinib The metabolism of Imatinib can be increased when combined with Siltuximab.
Sitagliptin	Sitagliptin The metabolism of Sitagliptin can be increased when combined with Siltuximab.
Bevacizumab Injection	Bevacizumab Injection The risk or severity of adverse effects can be increased when Bevacizumab is combined with Siltuximab.
Gefitinib	Gefitinib The metabolism of Gefitinib can be increased when combined with Siltuximab.
Paliperidone	Paliperidone The metabolism of Paliperidone can be increased when combined with Siltuximab.
Bortezomib	Bortezomib The metabolism of Bortezomib can be increased when combined with Siltuximab.
Clofarabine Injection	Clofarabine Injection The risk or severity of adverse effects can be increased when Clofarabine is combined with Siltuximab.
Hepatitis B Vaccine	Hepatitis B Vaccine The therapeutic efficacy of Hepatitis B Vaccine (Recombinant) can be decreased when used in combination with Siltuximab.
Influenza Vaccine, Inactivated or Recombinant	Influenza Vaccine, Inactivated or Recombinant The therapeutic efficacy of Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Siltuximab.
Influenza Vaccine, Live Intranasal	Influenza Vaccine, Live Intranasal The risk or severity of infection can be increased when Typhoid Vaccine Live is combined with Siltuximab.
Live Shingles (Zoster) Vaccine (ZVL)	Live Shingles (Zoster) Vaccine (ZVL) The risk or severity of infection can be increased when Varicella Zoster Vaccine (Live/attenuated) is combined with Siltuximab.
Oxaliplatin Injection	Oxaliplatin Injection The risk or severity of adverse effects can be increased when Oxaliplatin is combined with Siltuximab.
Primaquine	Primaquine The metabolism of Primaquine can be increased when combined with Siltuximab.
Rituximab Injection	Rituximab Injection The risk or severity of adverse effects can be increased when Rituximab is combined with Siltuximab.
Cetuximab Injection	Cetuximab Injection The risk or severity of adverse effects can be increased when Cetuximab is combined with Siltuximab.
Pemetrexed Injection	Pemetrexed Injection The metabolism of Pemetrexed can be increased when combined with Siltuximab.
Ranibizumab Injection	Ranibizumab Injection The risk or severity of adverse effects can be increased when Ranibizumab is combined with Siltuximab.
Lisdexamfetamine	Lisdexamfetamine The metabolism of Lisdexamfetamine can be increased when combined with Siltuximab.
Retapamulin	Retapamulin The metabolism of Retapamulin can be decreased when combined with Siltuximab.
Vorinostat	Vorinostat The risk or severity of adverse effects can be increased when Vorinostat is combined with Siltuximab.
Sorafenib	Sorafenib The metabolism of Sorafenib can be increased when combined with Siltuximab.
Sunitinib	Sunitinib The metabolism of Sunitinib can be increased when combined with Siltuximab.
Dronabinol	Dronabinol The metabolism of Dronabinol can be increased when combined with Siltuximab.
Lapatinib	Lapatinib The metabolism of Lapatinib can be increased when combined with Siltuximab.
Dasatinib	Dasatinib The metabolism of Dasatinib can be increased when combined with Siltuximab.
Mexiletine	Mexiletine The metabolism of Mexiletine can be increased when combined with Siltuximab.
Panitumumab Injection	Panitumumab Injection The risk or severity of adverse effects can be increased when Panitumumab is combined with Siltuximab.
Azacitidine Injection	Azacitidine Injection The risk or severity of adverse effects can be increased when Azacitidine is combined with Siltuximab.
Temsirolimus	Temsirolimus The metabolism of Temsirolimus can be increased when combined with Siltuximab.
Nelarabine Injection	Nelarabine Injection The risk or severity of adverse effects can be increased when Nelarabine is combined with Siltuximab.
Lenalidomide	Lenalidomide The risk or severity of adverse effects can be increased when Lenalidomide is combined with Siltuximab.
Nilotinib	Nilotinib The metabolism of Siltuximab can be increased when combined with Nilotinib.
Bexarotene	Bexarotene The metabolism of Bexarotene can be increased when combined with Siltuximab.
Budesonide	Budesonide The risk or severity of adverse effects can be increased when Budesonide is combined with Siltuximab.
Chloramphenicol Injection	Chloramphenicol Injection The risk or severity of adverse effects can be increased when Chloramphenicol is combined with Siltuximab.
Decitabine Injection	Decitabine Injection The risk or severity of adverse effects can be increased when Decitabine is combined with Siltuximab.
Etravirine	Etravirine The metabolism of Etravirine can be increased when combined with Siltuximab.
Arsenic Trioxide Injection	Arsenic Trioxide Injection The risk or severity of adverse effects can be increased when Arsenic trioxide is combined with Siltuximab.
Mitoxantrone Injection	Mitoxantrone Injection The risk or severity of adverse effects can be increased when Mitoxantrone is combined with Siltuximab.
Cevimeline	Cevimeline The metabolism of Cevimeline can be increased when combined with Siltuximab.
Nebivolol	Nebivolol The metabolism of Nebivolol can be increased when combined with Siltuximab.
Tretinoin	Tretinoin The metabolism of Tretinoin can be increased when combined with Siltuximab.
Bendamustine Injection	Bendamustine Injection The metabolism of Bendamustine can be increased when combined with Siltuximab.
Flecainide	Flecainide The metabolism of Flecainide can be increased when combined with Siltuximab.
Certolizumab Injection	Certolizumab Injection The risk or severity of adverse effects can be increased when Certolizumab pegol is combined with Siltuximab.
Ixabepilone Injection	Ixabepilone Injection The metabolism of Siltuximab can be increased when combined with Ixabepilone.
Irinotecan Injection	Irinotecan Injection The metabolism of Irinotecan can be increased when combined with Siltuximab.
Estramustine	Estramustine The risk or severity of adverse effects can be increased when Estramustine is combined with Siltuximab.
Praziquantel	Praziquantel The metabolism of Praziquantel can be increased when combined with Siltuximab.
Alemtuzumab Injection (Chronic Lymphocytic Leukemia)	Alemtuzumab Injection (Chronic Lymphocytic Leukemia) The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Siltuximab.
Rufinamide	Rufinamide The metabolism of Rufinamide can be increased when combined with Siltuximab.
Midazolam	Midazolam The serum concentration of Midazolam can be increased when it is combined with Siltuximab.
Dexrazoxane Injection	Dexrazoxane Injection The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Siltuximab.
Eltrombopag	Eltrombopag The metabolism of Eltrombopag can be increased when combined with Siltuximab.
Ibritumomab Injection	Ibritumomab Injection The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Siltuximab.
Milnacipran	Milnacipran The metabolism of Milnacipran can be increased when combined with Siltuximab.
Dexlansoprazole	Dexlansoprazole The metabolism of Dexlansoprazole can be increased when combined with Siltuximab.
Fesoterodine	Fesoterodine The metabolism of Fesoterodine can be increased when combined with Siltuximab.
Betaxolol	Betaxolol The metabolism of Betaxolol can be increased when combined with Siltuximab.
Iloperidone	Iloperidone The metabolism of Iloperidone can be decreased when combined with Siltuximab.
Prasugrel	Prasugrel The metabolism of Prasugrel can be increased when combined with Siltuximab.
Lacosamide	Lacosamide The metabolism of Lacosamide can be increased when combined with Siltuximab.
Everolimus	Everolimus The metabolism of Everolimus can be increased when combined with Siltuximab.
Tolvaptan (low blood sodium)	Tolvaptan (low blood sodium) The metabolism of Tolvaptan can be increased when combined with Siltuximab.
Dronedarone	Dronedarone The metabolism of Dronedarone can be increased when combined with Siltuximab.
Pralatrexate Injection	Pralatrexate Injection The risk or severity of adverse effects can be increased when Pralatrexate is combined with Siltuximab.
Palonosetron Injection	Palonosetron Injection The metabolism of Palonosetron can be increased when combined with Siltuximab.
Saxagliptin	Saxagliptin The metabolism of Saxagliptin can be increased when combined with Siltuximab.
Romidepsin Injection	Romidepsin Injection The metabolism of Romidepsin can be increased when combined with Siltuximab.
Tapentadol	Tapentadol The metabolism of Tapentadol can be increased when combined with Siltuximab.
Topotecan	Topotecan The risk or severity of adverse effects can be increased when Topotecan is combined with Siltuximab.
Ofatumumab Injection (Chronic Lymphocytic Leukemia)	Ofatumumab Injection (Chronic Lymphocytic Leukemia) The risk or severity of adverse effects can be increased when Ofatumumab is combined with Siltuximab.
Golimumab Injection	Golimumab Injection The risk or severity of adverse effects can be increased when Golimumab is combined with Siltuximab.
Pazopanib	Pazopanib The metabolism of Pazopanib can be increased when combined with Siltuximab.
Asenapine	Asenapine The metabolism of Asenapine can be increased when combined with Siltuximab.
Pitavastatin	Pitavastatin The metabolism of Pitavastatin can be increased when combined with Siltuximab.
Albendazole	Albendazole The metabolism of Albendazole can be increased when combined with Siltuximab.
Ulipristal	Ulipristal The metabolism of Ulipristal can be increased when combined with Siltuximab.
Levonorgestrel	Levonorgestrel The metabolism of Levonorgestrel can be increased when combined with Siltuximab.
Oxymorphone	Oxymorphone The metabolism of Oxymorphone can be increased when combined with Siltuximab.
Denosumab Injection	Denosumab Injection The risk or severity of adverse effects can be increased when Denosumab is combined with Siltuximab.
Tocilizumab Injection	Tocilizumab Injection The risk or severity of adverse effects can be increased when Tocilizumab is combined with Siltuximab.
Fingolimod	Fingolimod Siltuximab may increase the immunosuppressive activities of Fingolimod.
Eribulin Injection	Eribulin Injection The risk or severity of adverse effects can be increased when Eribulin is combined with Siltuximab.
Cabazitaxel Injection	Cabazitaxel Injection The metabolism of Cabazitaxel can be increased when combined with Siltuximab.
Ustekinumab Injection	Ustekinumab Injection The risk or severity of adverse effects can be increased when Ustekinumab is combined with Siltuximab.
Acetaminophen Injection	Acetaminophen Injection The metabolism of Acetaminophen can be increased when combined with Siltuximab.
Vilazodone	Vilazodone The metabolism of Vilazodone can be increased when combined with Siltuximab.
Ipilimumab Injection	Ipilimumab Injection The risk or severity of adverse effects can be increased when Ipilimumab is combined with Siltuximab.
Denileukin Diftitox Injection	Denileukin Diftitox Injection The risk or severity of adverse effects can be increased when Aldesleukin is combined with Siltuximab.
Sipuleucel-T Injection	Sipuleucel-T Injection The therapeutic efficacy of Sipuleucel-T can be decreased when used in combination with Siltuximab.
Belimumab Injection	Belimumab Injection The risk or severity of adverse effects can be increased when Belimumab is combined with Siltuximab.
Busulfan Injection	Busulfan Injection The metabolism of Busulfan can be increased when combined with Siltuximab.
Roflumilast	Roflumilast Siltuximab may increase the immunosuppressive activities of Roflumilast.
Linagliptin	Linagliptin The metabolism of Linagliptin can be increased when combined with Siltuximab.
Cyclophosphamide Injection	Cyclophosphamide Injection The metabolism of Cyclophosphamide can be increased when combined with Siltuximab.
Rivaroxaban	Rivaroxaban The metabolism of Rivaroxaban can be increased when combined with Siltuximab.
Brentuximab Vedotin Injection	Brentuximab Vedotin Injection The metabolism of Siltuximab can be increased when combined with Brentuximab vedotin.
Ruxolitinib	Ruxolitinib The metabolism of Siltuximab can be increased when combined with Ruxolitinib.
Vandetanib	Vandetanib The metabolism of Vandetanib can be increased when combined with Siltuximab.
Clobazam	Clobazam The metabolism of Clobazam can be increased when combined with Siltuximab.
Vemurafenib	Vemurafenib The metabolism of Vemurafenib can be increased when combined with Siltuximab.
Vismodegib	Vismodegib The metabolism of Vismodegib can be increased when combined with Siltuximab.
Belatacept Injection	Belatacept Injection The risk or severity of adverse effects can be increased when Belatacept is combined with Siltuximab.
Ivacaftor	Ivacaftor The metabolism of Ivacaftor can be increased when combined with Siltuximab.
Basiliximab Injection	Basiliximab Injection The risk or severity of adverse effects can be increased when Basiliximab is combined with Siltuximab.
Axitinib	Axitinib The metabolism of Axitinib can be increased when combined with Siltuximab.
Crizotinib	Crizotinib The metabolism of Crizotinib can be increased when combined with Siltuximab.
Melphalan Injection	Melphalan Injection The risk or severity of adverse effects can be increased when Melphalan is combined with Siltuximab.
Cabergoline	Cabergoline The metabolism of Cabergoline can be increased when combined with Siltuximab.
Ambrisentan	Ambrisentan The metabolism of Ambrisentan can be increased when combined with Siltuximab.
Eculizumab Injection	Eculizumab Injection The risk or severity of adverse effects can be increased when Eculizumab is combined with Siltuximab.
Pertuzumab Injection	Pertuzumab Injection The risk or severity of adverse effects can be increased when Pertuzumab is combined with Siltuximab.
Carfilzomib Injection	Carfilzomib Injection The risk or severity of adverse effects can be increased when Carfilzomib is combined with Siltuximab.
Enzalutamide	Enzalutamide The metabolism of Enzalutamide can be increased when combined with Siltuximab.
Mirabegron	Mirabegron The metabolism of Mirabegron can be increased when combined with Siltuximab.
Regorafenib	Regorafenib The metabolism of Regorafenib can be increased when combined with Siltuximab.
Bosutinib	Bosutinib The metabolism of Siltuximab can be increased when combined with Bosutinib.
Corticotropin, Repository Injection	Corticotropin, Repository Injection The risk or severity of adverse effects can be increased when Corticotropin is combined with Siltuximab.
Teriflunomide	Teriflunomide The risk or severity of adverse effects can be increased when Teriflunomide is combined with Siltuximab.
Cabozantinib (thyroid cancer)	Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be increased when combined with Siltuximab.
Tofacitinib	Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Siltuximab.
Alogliptin	Alogliptin The metabolism of Alogliptin can be increased when combined with Siltuximab.
Dimethyl Fumarate	Dimethyl Fumarate The risk or severity of adverse effects can be increased when Dimethyl fumarate is combined with Siltuximab.
Ponatinib	Ponatinib The metabolism of Ponatinib can be increased when combined with Siltuximab.
Pomalidomide	Pomalidomide The metabolism of Pomalidomide can be increased when combined with Siltuximab.
Ado-trastuzumab Emtansine Injection	Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be increased when combined with Siltuximab.
Apixaban	Apixaban The metabolism of Apixaban can be increased when combined with Siltuximab.
Dabrafenib	Dabrafenib The metabolism of Dabrafenib can be increased when combined with Siltuximab.
Ospemifene	Ospemifene The metabolism of Ospemifene can be increased when combined with Siltuximab.
Levomilnacipran	Levomilnacipran The metabolism of Levomilnacipran can be increased when combined with Siltuximab.
Vortioxetine	Vortioxetine The metabolism of Vortioxetine can be increased when combined with Siltuximab.
Perampanel	Perampanel The metabolism of Perampanel can be increased when combined with Siltuximab.
Ibrutinib	Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Siltuximab.
Lomitapide	Lomitapide The metabolism of Lomitapide can be decreased when combined with Siltuximab.
Ketorolac Injection	Ketorolac Injection The metabolism of Ketorolac can be increased when combined with Siltuximab.
Obinutuzumab Injection	Obinutuzumab Injection The risk or severity of adverse effects can be increased when Obinutuzumab is combined with Siltuximab.
Dapagliflozin	Dapagliflozin The metabolism of Dapagliflozin can be increased when combined with Siltuximab.
Apremilast	Apremilast The metabolism of Siltuximab can be increased when combined with Apremilast.
Ramucirumab Injection	Ramucirumab Injection The risk or severity of adverse effects can be increased when Ramucirumab is combined with Siltuximab.
Ceritinib	Ceritinib The metabolism of Ceritinib can be increased when combined with Siltuximab.
Vedolizumab Injection	Vedolizumab Injection The risk or severity of adverse effects can be increased when Vedolizumab is combined with Siltuximab.
Belinostat Injection	Belinostat Injection The risk or severity of adverse effects can be increased when Belinostat is combined with Siltuximab.
Idelalisib	Idelalisib The metabolism of Idelalisib can be increased when combined with Siltuximab.
Testosterone Injection	Testosterone Injection The metabolism of Testosterone can be increased when combined with Siltuximab.
Vorapaxar	Vorapaxar The metabolism of Vorapaxar can be increased when combined with Siltuximab.
Hydrocodone	Hydrocodone The metabolism of Hydrocodone can be increased when combined with Siltuximab.
Suvorexant	Suvorexant The metabolism of Suvorexant can be increased when combined with Siltuximab.
Dulaglutide Injection	Dulaglutide Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Dulaglutide.
Pembrolizumab Injection	Pembrolizumab Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Pembrolizumab.
Nivolumab Injection	Nivolumab Injection The risk or severity of adverse effects can be increased when Nivolumab is combined with Siltuximab.
Peginterferon Beta-1a Injection	Peginterferon Beta-1a Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Peginterferon beta-1a.
Olaparib	Olaparib The metabolism of Olaparib can be increased when combined with Siltuximab.
Blinatumomab Injection	Blinatumomab Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Blinatumomab.
Methamphetamine	Methamphetamine The metabolism of Metamfetamine can be increased when combined with Siltuximab.
Tasimelteon	Tasimelteon The metabolism of Tasimelteon can be increased when combined with Siltuximab.
Riociguat	Riociguat The metabolism of Riociguat can be increased when combined with Siltuximab.
Pirfenidone	Pirfenidone The metabolism of Pirfenidone can be increased when combined with Siltuximab.
Nintedanib	Nintedanib The metabolism of Nintedanib can be increased when combined with Siltuximab.
Secukinumab Injection	Secukinumab Injection The risk or severity of adverse effects can be increased when Secukinumab is combined with Siltuximab.
Risperidone Injection	Risperidone Injection The metabolism of Risperidone can be increased when combined with Siltuximab.
Palbociclib	Palbociclib The metabolism of Palbociclib can be increased when combined with Siltuximab.
Panobinostat	Panobinostat The metabolism of Siltuximab can be increased when combined with Panobinostat.
Dinutuximab Injection	Dinutuximab Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Dinutuximab.
Haloperidol Injection	Haloperidol Injection The serum concentration of Haloperidol can be increased when it is combined with Siltuximab.
Sonidegib	Sonidegib The metabolism of Sonidegib can be increased when combined with Siltuximab.
Alirocumab Injection	Alirocumab Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Alirocumab.
Prednisolone	Prednisolone The risk or severity of adverse effects can be increased when Prednisolone is combined with Siltuximab.
Evolocumab Injection	Evolocumab Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Evolocumab.
Daclatasvir	Daclatasvir The metabolism of Daclatasvir can be increased when combined with Siltuximab.
Brexpiprazole	Brexpiprazole The metabolism of Brexpiprazole can be increased when combined with Siltuximab.
Ziprasidone Injection	Ziprasidone Injection The metabolism of Ziprasidone can be increased when combined with Siltuximab.
Cariprazine	Cariprazine The metabolism of Cariprazine can be increased when combined with Siltuximab.
Cobimetinib	Cobimetinib The metabolism of Cobimetinib can be increased when combined with Siltuximab.
Mepolizumab Injection	Mepolizumab Injection The risk or severity of adverse effects can be increased when Mepolizumab is combined with Siltuximab.
Trabectedin Injection	Trabectedin Injection The metabolism of Trabectedin can be increased when combined with Siltuximab.
Elotuzumab Injection	Elotuzumab Injection The risk or severity of adverse effects can be increased when Elotuzumab is combined with Siltuximab.
Daratumumab Injection	Daratumumab Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Daratumumab.
Osimertinib	Osimertinib The metabolism of Osimertinib can be increased when combined with Siltuximab.
Alectinib	Alectinib The metabolism of Alectinib can be increased when combined with Siltuximab.
Ixazomib	Ixazomib The metabolism of Ixazomib can be increased when combined with Siltuximab.
Necitumumab Injection	Necitumumab Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Necitumumab.
Lesinurad	Lesinurad The metabolism of Lesinurad can be increased when combined with Siltuximab.
Dexamethasone Injection	Dexamethasone Injection The metabolism of Siltuximab can be increased when combined with Dexamethasone.
Reslizumab Injection	Reslizumab Injection The risk or severity of adverse effects can be increased when Reslizumab is combined with Siltuximab.
Ixekizumab Injection	Ixekizumab Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Ixekizumab.
Brivaracetam Injection	Brivaracetam Injection The metabolism of Brivaracetam can be increased when combined with Siltuximab.
Venetoclax	Venetoclax The metabolism of Venetoclax can be increased when combined with Siltuximab.
Cobicistat	Cobicistat The metabolism of Cobicistat can be increased when combined with Siltuximab.
Selexipag	Selexipag The metabolism of Selexipag can be increased when combined with Siltuximab.
Atezolizumab Injection	Atezolizumab Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Atezolizumab.
Diphenhydramine Injection	Diphenhydramine Injection The metabolism of Diphenhydramine can be increased when combined with Siltuximab.
Olaratumab Injection	Olaratumab Injection The risk or severity of adverse effects can be increased when Olaratumab is combined with Siltuximab.
Rucaparib	Rucaparib The metabolism of Rucaparib can be increased when combined with Siltuximab.
Bezlotoxumab Injection	Bezlotoxumab Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Bezlotoxumab.
Avelumab Injection	Avelumab Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Avelumab.
Ribociclib	Ribociclib The metabolism of Ribociclib can be increased when combined with Siltuximab.
Brodalumab Injection	Brodalumab Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Brodalumab.
Brigatinib	Brigatinib The metabolism of Brigatinib can be increased when combined with Siltuximab.
Doxepin (Insomnia)	Doxepin (Insomnia) The metabolism of Doxepin can be increased when combined with Siltuximab.
Dupilumab Injection	Dupilumab Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Dupilumab.
Deutetrabenazine	Deutetrabenazine The metabolism of Deutetrabenazine can be increased when combined with Siltuximab.
Valbenazine	Valbenazine The metabolism of Valbenazine can be increased when combined with Siltuximab.
Deflazacort	Deflazacort The risk or severity of adverse effects can be increased when Siltuximab is combined with Deflazacort.
Ocrelizumab Injection	Ocrelizumab Injection Ocrelizumab may increase the immunosuppressive activities of Siltuximab.
Durvalumab Injection	Durvalumab Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Durvalumab.
Sarilumab Injection	Sarilumab Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Sarilumab.
Midostaurin	Midostaurin The metabolism of Midostaurin can be increased when combined with Siltuximab.
Neratinib	Neratinib The metabolism of Neratinib can be increased when combined with Siltuximab.
Guselkumab Injection	Guselkumab Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Guselkumab.
Enasidenib	Enasidenib The metabolism of Enasidenib can be increased when combined with Siltuximab.
Inotuzumab Ozogamicin Injection	Inotuzumab Ozogamicin Injection The risk or severity of adverse effects can be increased when Inotuzumab ozogamicin is combined with Siltuximab.
Aprepitant/Fosaprepitant Injection	Aprepitant/Fosaprepitant Injection The metabolism of Fosaprepitant can be increased when combined with Siltuximab.
Copanlisib Injection	Copanlisib Injection The metabolism of Copanlisib can be increased when combined with Siltuximab.
Abemaciclib	Abemaciclib The metabolism of Abemaciclib can be increased when combined with Siltuximab.
Benralizumab Injection	Benralizumab Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Benralizumab.
Acalabrutinib	Acalabrutinib The metabolism of Acalabrutinib can be increased when combined with Siltuximab.
Gemtuzumab Ozogamicin Injection	Gemtuzumab Ozogamicin Injection The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Siltuximab.
Letermovir	Letermovir The metabolism of Letermovir can be increased when combined with Siltuximab.
Tetrabenazine	Tetrabenazine The metabolism of Tetrabenazine can be increased when combined with Siltuximab.
Buprenorphine Injection	Buprenorphine Injection The metabolism of Buprenorphine can be increased when combined with Siltuximab.
Apalutamide	Apalutamide The metabolism of Apalutamide can be increased when combined with Siltuximab.
Ibalizumab-uiyk Injection	Ibalizumab-uiyk Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Ibalizumab.
Penicillamine	Penicillamine The risk or severity of adverse effects can be increased when Penicillamine is combined with Siltuximab.
Tildrakizumab-asmn injection	Tildrakizumab-asmn injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Tildrakizumab.
Erenumab-aooe Injection	Erenumab-aooe Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Erenumab.
Baricitinib	Baricitinib The metabolism of Baricitinib can be increased when combined with Siltuximab.
Burosumab-twza Injection	Burosumab-twza Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Burosumab.
Lofexidine	Lofexidine The metabolism of Lofexidine can be increased when combined with Siltuximab.
Eliglustat	Eliglustat The metabolism of Eliglustat can be decreased when combined with Siltuximab.
Encorafenib	Encorafenib The metabolism of Encorafenib can be increased when combined with Siltuximab.
Binimetinib	Binimetinib The metabolism of Binimetinib can be increased when combined with Siltuximab.
Ivosidenib	Ivosidenib The metabolism of Ivosidenib can be increased when combined with Siltuximab.
Elagolix	Elagolix The metabolism of Elagolix can be increased when combined with Siltuximab.
Doravirine	Doravirine The metabolism of Doravirine can be increased when combined with Siltuximab.
Tafenoquine	Tafenoquine The metabolism of Tafenoquine can be increased when combined with Siltuximab.
Cannabidiol	Cannabidiol The metabolism of Cannabidiol can be increased when combined with Siltuximab.
Cemiplimab-rwlc Injection	Cemiplimab-rwlc Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Cemiplimab.
Dacomitinib	Dacomitinib The metabolism of Dacomitinib can be increased when combined with Siltuximab.
Duvelisib	Duvelisib The metabolism of Duvelisib can be increased when combined with Siltuximab.
Galcanezumab-gnlm Injection	Galcanezumab-gnlm Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Galcanezumab.
Mogamulizumab-kpkc Injection	Mogamulizumab-kpkc Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Mogamulizumab.
Stiripentol	Stiripentol The metabolism of Stiripentol can be increased when combined with Siltuximab.
Gilteritinib	Gilteritinib The metabolism of Gilteritinib can be increased when combined with Siltuximab.
Glasdegib	Glasdegib The metabolism of Glasdegib can be increased when combined with Siltuximab.
Lorlatinib	Lorlatinib The metabolism of Lorlatinib can be increased when combined with Siltuximab.
Methoxy Polyethylene Glycol-Epoetin Beta Injection	Methoxy Polyethylene Glycol-Epoetin Beta Injection The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Siltuximab.
Paclitaxel (with albumin) Injection	Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be increased when combined with Siltuximab.
Prucalopride	Prucalopride The metabolism of Prucalopride can be decreased when combined with Siltuximab.
Ravulizumab-cwvz Injection	Ravulizumab-cwvz Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Ravulizumab.
Emapalumab-lzsg Injection	Emapalumab-lzsg Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Emapalumab.
Romosozumab-aqqg Injection	Romosozumab-aqqg Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Romosozumab.
Siponimod	Siponimod The metabolism of Siponimod can be increased when combined with Siltuximab.
Acyclovir Ophthalmic	Acyclovir Ophthalmic The metabolism of Acyclovir can be increased when combined with Siltuximab.
Caplacizumab-yhdp Injection	Caplacizumab-yhdp Injection The risk or severity of adverse effects can be increased when Caplacizumab is combined with Siltuximab.
Erdafitinib	Erdafitinib The metabolism of Erdafitinib can be increased when combined with Siltuximab.
Esomeprazole Injection	Esomeprazole Injection The metabolism of Esomeprazole can be increased when combined with Siltuximab.
Risankizumab-rzaa Injection	Risankizumab-rzaa Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Risankizumab.
Alpelisib	Alpelisib The metabolism of Alpelisib can be increased when combined with Siltuximab.
Cladribine	Cladribine The risk or severity of adverse effects can be increased when Cladribine is combined with Siltuximab.
Polatuzumab vedotin-piiq Injection	Polatuzumab vedotin-piiq Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Polatuzumab vedotin.
Triclabendazole	Triclabendazole The metabolism of Triclabendazole can be increased when combined with Siltuximab.
Entrectinib	Entrectinib The metabolism of Entrectinib can be increased when combined with Siltuximab.
Pexidartinib	Pexidartinib The metabolism of Pexidartinib can be increased when combined with Siltuximab.
Istradefylline	Istradefylline The metabolism of Istradefylline can be increased when combined with Siltuximab.
Pitolisant	Pitolisant The metabolism of Pitolisant can be increased when combined with Siltuximab.
Fedratinib	Fedratinib The metabolism of Fedratinib can be increased when combined with Siltuximab.
Lefamulin	Lefamulin The metabolism of Lefamulin can be increased when combined with Siltuximab.
Phenytoin Injection	Phenytoin Injection The metabolism of Phenytoin can be increased when combined with Siltuximab.
Fosphenytoin Injection	Fosphenytoin Injection The metabolism of Fosphenytoin can be increased when combined with Siltuximab.
Brolucizumab-dbll Injection	Brolucizumab-dbll Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Brolucizumab.
Fam-trastuzumab deruxtecan-nxki Injection	Fam-trastuzumab deruxtecan-nxki Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Trastuzumab deruxtecan.
Zanubrutinib	Zanubrutinib The metabolism of Zanubrutinib can be increased when combined with Siltuximab.
Voxelotor	Voxelotor The serum concentration of Voxelotor can be increased when it is combined with Siltuximab.
Avapritinib	Avapritinib The metabolism of Avapritinib can be increased when combined with Siltuximab.
Lumateperone	Lumateperone The serum concentration of Lumateperone can be decreased when it is combined with Siltuximab.
Ubrogepant	Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Siltuximab.
Tazemetostat	Tazemetostat The metabolism of Tazemetostat can be increased when combined with Siltuximab.
Cenobamate	Cenobamate The metabolism of Cenobamate can be increased when combined with Siltuximab.
Isatuximab-irfc Injection	Isatuximab-irfc Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Isatuximab.
Teprotumumab-trbw Injection	Teprotumumab-trbw Injection The risk or severity of adverse effects can be increased when Teprotumumab is combined with Siltuximab.
Ozanimod	Ozanimod The risk or severity of adverse effects can be increased when Siltuximab is combined with Ozanimod.
Selumetinib	Selumetinib The metabolism of Selumetinib can be increased when combined with Siltuximab.
Rimegepant	Rimegepant The metabolism of Rimegepant can be increased when combined with Siltuximab.
Tucatinib	Tucatinib The metabolism of Tucatinib can be increased when combined with Siltuximab.
Sacituzumab govitecan-hziy Injection	Sacituzumab govitecan-hziy Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Sacituzumab govitecan.
Selpercatinib	Selpercatinib The serum concentration of Selpercatinib can be decreased when it is combined with Siltuximab.
Capmatinib	Capmatinib The serum concentration of Capmatinib can be decreased when it is combined with Siltuximab.
Lemborexant	Lemborexant The serum concentration of Lemborexant can be decreased when it is combined with Siltuximab.
Luspatercept-aamt Injection	Luspatercept-aamt Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Luspatercept.
Belantamab Mafodotin-blmf Injection	Belantamab Mafodotin-blmf Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Belantamab mafodotin.
Tafasitamab-cxix Injection	Tafasitamab-cxix Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Tafasitamab.
Margetuximab-cmkb Injection	Margetuximab-cmkb Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Margetuximab.
Progestin-Only (drospirenone) Oral Contraceptives	Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Drospirenone can be increased when combined with Siltuximab.
Evinacumab-dgnb Injection	Evinacumab-dgnb Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Evinacumab.
Aducanumab-avwa Injection	Aducanumab-avwa Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Aducanumab.
Anifrolumab-fnia Injection	Anifrolumab-fnia Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Anifrolumab.
Theophylline	Theophylline The metabolism of Theophylline can be increased when combined with Siltuximab.
Indomethacin	Indomethacin The metabolism of Indomethacin can be increased when combined with Siltuximab.
Mefenamic Acid	Mefenamic Acid The metabolism of Mefenamic acid can be increased when combined with Siltuximab.
Naproxen	Naproxen The metabolism of Naproxen can be increased when combined with Siltuximab.
Trazodone	Trazodone The metabolism of Trazodone can be increased when combined with Siltuximab.
Hydroxyurea	Hydroxyurea The risk or severity of adverse effects can be increased when Hydroxyurea is combined with Siltuximab.
Floxuridine	Floxuridine The risk or severity of adverse effects can be increased when Floxuridine is combined with Siltuximab.
Phenobarbital	Phenobarbital The metabolism of Phenobarbital can be increased when combined with Siltuximab.
Methotrexate Injection	Methotrexate Injection The metabolism of Siltuximab can be increased when combined with Methotrexate.
Primidone	Primidone The metabolism of Primidone can be increased when combined with Siltuximab.
Methsuximide	Methsuximide The metabolism of Methsuximide can be increased when combined with Siltuximab.
Chlorpromazine	Chlorpromazine The metabolism of Chlorpromazine can be increased when combined with Siltuximab.
Diazepam	Diazepam The metabolism of Diazepam can be increased when combined with Siltuximab.
Flurazepam	Flurazepam The metabolism of Flurazepam can be increased when combined with Siltuximab.
Lorazepam	Lorazepam The metabolism of Lorazepam can be increased when combined with Siltuximab.
Carmustine	Carmustine The metabolism of Carmustine can be increased when combined with Siltuximab.
Codeine	Codeine The metabolism of Codeine can be increased when combined with Siltuximab.
Procarbazine	Procarbazine The risk or severity of adverse effects can be increased when Procarbazine is combined with Siltuximab.
Thioguanine	Thioguanine The risk or severity of adverse effects can be increased when Tioguanine is combined with Siltuximab.
Prochlorperazine	Prochlorperazine The metabolism of Prochlorperazine can be increased when combined with Siltuximab.
Thioridazine	Thioridazine The metabolism of Thioridazine can be increased when combined with Siltuximab.
Trifluoperazine	Trifluoperazine The metabolism of Trifluoperazine can be increased when combined with Siltuximab.
Bleomycin	Bleomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Siltuximab.
Dapsone	Dapsone The metabolism of Dapsone can be increased when combined with Siltuximab.
Sulfadiazine	Sulfadiazine The metabolism of Sulfadiazine can be increased when combined with Siltuximab.
Oxycodone	Oxycodone The metabolism of Oxycodone can be increased when combined with Siltuximab.
Methadone	Methadone The metabolism of Methadone can be increased when combined with Siltuximab.
Oxybutynin	Oxybutynin The metabolism of Oxybutynin can be increased when combined with Siltuximab.
Benztropine	Benztropine The metabolism of Benzatropine can be increased when combined with Siltuximab.
Maprotiline	Maprotiline The metabolism of Maprotiline can be increased when combined with Siltuximab.
Ibuprofen	Ibuprofen The metabolism of Ibuprofen can be increased when combined with Siltuximab.
Perphenazine	Perphenazine The metabolism of Perphenazine can be increased when combined with Siltuximab.
Azathioprine	Azathioprine The metabolism of Azathioprine can be increased when combined with Siltuximab.
Phentermine	Phentermine The metabolism of Phentermine can be increased when combined with Siltuximab.
Amoxapine	Amoxapine The metabolism of Amoxapine can be increased when combined with Siltuximab.
Sulfasalazine	Sulfasalazine The risk or severity of adverse effects can be increased when Sulfasalazine is combined with Siltuximab.
Hydrocortisone	Hydrocortisone The metabolism of Hydrocortisone can be increased when combined with Siltuximab.
Lomustine	Lomustine The risk or severity of adverse effects can be increased when Lomustine is combined with Siltuximab.
Doxorubicin	Doxorubicin The metabolism of Siltuximab can be increased when combined with Doxorubicin.
Cytarabine	Cytarabine The risk or severity of adverse effects can be increased when Cytarabine is combined with Siltuximab.
Mechlorethamine	Mechlorethamine The risk or severity of adverse effects can be increased when Mechlorethamine is combined with Siltuximab.
Dactinomycin	Dactinomycin The risk or severity of adverse effects can be increased when Dactinomycin is combined with Siltuximab.
Carbamazepine	Carbamazepine The metabolism of Siltuximab can be increased when combined with Carbamazepine.
Clonidine	Clonidine The metabolism of Clonidine can be increased when combined with Siltuximab.
Warfarin	Warfarin The metabolism of Warfarin can be increased when combined with Siltuximab.
Clonazepam	Clonazepam The metabolism of Clonazepam can be increased when combined with Siltuximab.
Loperamide	Loperamide The metabolism of Loperamide can be increased when combined with Siltuximab.
Promethazine	Promethazine The metabolism of Promethazine can be increased when combined with Siltuximab.
Daunorubicin	Daunorubicin The risk or severity of adverse effects can be increased when Daunorubicin is combined with Siltuximab.
Chloroquine	Chloroquine The metabolism of Chloroquine can be increased when combined with Siltuximab.
Quinine	Quinine The metabolism of Quinine can be increased when combined with Siltuximab.
Ethosuximide	Ethosuximide The metabolism of Ethosuximide can be increased when combined with Siltuximab.
Triamterene	Triamterene The metabolism of Triamterene can be increased when combined with Siltuximab.
Isosorbide	Isosorbide The metabolism of Isosorbide can be increased when combined with Siltuximab.
Clindamycin Injection	Clindamycin Injection The metabolism of Clindamycin can be increased when combined with Siltuximab.
Desipramine	Desipramine The metabolism of Desipramine can be increased when combined with Siltuximab.
Amitriptyline	Amitriptyline The metabolism of Amitriptyline can be increased when combined with Siltuximab.
Imipramine	Imipramine The metabolism of Imipramine can be increased when combined with Siltuximab.
Quinidine	Quinidine The metabolism of Quinidine can be increased when combined with Siltuximab.
Procainamide	Procainamide The metabolism of Procainamide can be increased when combined with Siltuximab.
Disopyramide	Disopyramide The metabolism of Disopyramide can be increased when combined with Siltuximab.
Valproic Acid	Valproic Acid The metabolism of Valproic acid can be increased when combined with Siltuximab.
Tamoxifen	Tamoxifen The metabolism of Tamoxifen can be increased when combined with Siltuximab.
Mitomycin	Mitomycin The risk or severity of adverse effects can be increased when Mitomycin is combined with Siltuximab.
Methimazole	Methimazole The risk or severity of adverse effects can be increased when Methimazole is combined with Siltuximab.
Propylthiouracil	Propylthiouracil The risk or severity of adverse effects can be increased when Propylthiouracil is combined with Siltuximab.
Chlorpropamide	Chlorpropamide The metabolism of Chlorpropamide can be increased when combined with Siltuximab.
Tolbutamide	Tolbutamide The metabolism of Tolbutamide can be increased when combined with Siltuximab.
Tolazamide	Tolazamide The metabolism of Tolazamide can be increased when combined with Siltuximab.
Dextromethorphan	Dextromethorphan The metabolism of Dextromethorphan can be increased when combined with Siltuximab.
Cyclobenzaprine	Cyclobenzaprine The metabolism of Cyclobenzaprine can be increased when combined with Siltuximab.
Chlorpheniramine	Chlorpheniramine The metabolism of Chlorpheniramine can be increased when combined with Siltuximab.
Brompheniramine	Brompheniramine The metabolism of Brompheniramine can be increased when combined with Siltuximab.
Meclizine	Meclizine The metabolism of Meclizine can be increased when combined with Siltuximab.
Chlorzoxazone	Chlorzoxazone The metabolism of Chlorzoxazone can be increased when combined with Siltuximab.
Carisoprodol	Carisoprodol The metabolism of Carisoprodol can be increased when combined with Siltuximab.
Disulfiram	Disulfiram The metabolism of Disulfiram can be increased when combined with Siltuximab.
Propranolol (Cardiovascular)	Propranolol (Cardiovascular) The metabolism of Propranolol can be increased when combined with Siltuximab.
Nortriptyline	Nortriptyline The metabolism of Nortriptyline can be increased when combined with Siltuximab.
Mercaptopurine	Mercaptopurine The risk or severity of adverse effects can be increased when Mercaptopurine is combined with Siltuximab.
Nadolol	Nadolol The metabolism of Nadolol can be increased when combined with Siltuximab.
Fluorouracil Injection	Fluorouracil Injection The metabolism of Fluorouracil can be increased when combined with Siltuximab.
Colchicine	Colchicine The metabolism of Colchicine can be decreased when combined with Siltuximab.
Cephalexin	Cephalexin The metabolism of Cephalexin can be increased when combined with Siltuximab.
Dacarbazine	Dacarbazine The metabolism of Dacarbazine can be increased when combined with Siltuximab.
Bacillus Calmette-Guerin (BCG) Vaccine	Bacillus Calmette-Guerin (BCG) Vaccine The risk or severity of infection can be increased when Bacillus calmette-guerin substrain tice live antigen is combined with Siltuximab.
Thiotepa Injection	Thiotepa Injection The metabolism of Siltuximab can be increased when combined with Thiotepa.
Vincristine Injection	Vincristine Injection The metabolism of Vincristine can be increased when combined with Siltuximab.
Vinblastine	Vinblastine The metabolism of Siltuximab can be increased when combined with Vinblastine.
Metoprolol	Metoprolol The metabolism of Metoprolol can be increased when combined with Siltuximab.
Hydroxyzine	Hydroxyzine The metabolism of Hydroxyzine can be increased when combined with Siltuximab.
Thiothixene	Thiothixene The metabolism of Thiothixene can be increased when combined with Siltuximab.
Aspirin	Aspirin The metabolism of Acetylsalicylic acid can be increased when combined with Siltuximab.
Chlorambucil	Chlorambucil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Siltuximab.
Alprazolam	Alprazolam The metabolism of Alprazolam can be decreased when combined with Siltuximab.
Triazolam	Triazolam The metabolism of Triazolam can be increased when combined with Siltuximab.
Trimethoprim	Trimethoprim The metabolism of Trimethoprim can be increased when combined with Siltuximab.
Diltiazem	Diltiazem The metabolism of Diltiazem can be increased when combined with Siltuximab.
Nifedipine	Nifedipine The metabolism of Nifedipine can be increased when combined with Siltuximab.
Timolol	Timolol The metabolism of Timolol can be increased when combined with Siltuximab.
Verapamil	Verapamil The metabolism of Verapamil can be increased when combined with Siltuximab.
Atenolol	Atenolol The metabolism of Atenolol can be increased when combined with Siltuximab.
Pindolol	Pindolol The metabolism of Pindolol can be increased when combined with Siltuximab.
Cisplatin Injection	Cisplatin Injection The risk or severity of adverse effects can be increased when Cisplatin is combined with Siltuximab.
Piroxicam	Piroxicam The metabolism of Piroxicam can be increased when combined with Siltuximab.
Streptozocin	Streptozocin The risk or severity of adverse effects can be increased when Streptozocin is combined with Siltuximab.
Etoposide	Etoposide The metabolism of Etoposide can be increased when combined with Siltuximab.
Glyburide	Glyburide The metabolism of Glyburide can be increased when combined with Siltuximab.
Glipizide	Glipizide The metabolism of Glipizide can be increased when combined with Siltuximab.
Pentoxifylline	Pentoxifylline The metabolism of Pentoxifylline can be increased when combined with Siltuximab.
Pentamidine Injection	Pentamidine Injection The metabolism of Pentamidine can be increased when combined with Siltuximab.
Labetalol	Labetalol The metabolism of Labetalol can be increased when combined with Siltuximab.
Guanabenz	Guanabenz The metabolism of Guanabenz can be increased when combined with Siltuximab.
Pimozide	Pimozide The metabolism of Pimozide can be increased when combined with Siltuximab.
Flurbiprofen	Flurbiprofen The metabolism of Flurbiprofen can be increased when combined with Siltuximab.
Amiodarone	Amiodarone The metabolism of Amiodarone can be increased when combined with Siltuximab.
Buspirone	Buspirone The metabolism of Buspirone can be increased when combined with Siltuximab.
Lovastatin	Lovastatin The metabolism of Lovastatin can be decreased when combined with Siltuximab.
Diclofenac	Diclofenac The metabolism of Diclofenac can be increased when combined with Siltuximab.
Fluoxetine	Fluoxetine The metabolism of Fluoxetine can be increased when combined with Siltuximab.
Interferon Alfa-2b Injection	Interferon Alfa-2b Injection The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Siltuximab.
Clozapine	Clozapine The metabolism of Clozapine can be increased when combined with Siltuximab.
Idarubicin	Idarubicin The metabolism of Idarubicin can be increased when combined with Siltuximab.
Fludarabine Injection	Fludarabine Injection The risk or severity of adverse effects can be increased when Fludarabine is combined with Siltuximab.
Pentostatin Injection	Pentostatin Injection The risk or severity of adverse effects can be increased when Pentostatin is combined with Siltuximab.
Clarithromycin	Clarithromycin The metabolism of Clarithromycin can be increased when combined with Siltuximab.
Etodolac	Etodolac The metabolism of Etodolac can be increased when combined with Siltuximab.
Felodipine	Felodipine The metabolism of Felodipine can be increased when combined with Siltuximab.
Nabumetone	Nabumetone The metabolism of Nabumetone can be increased when combined with Siltuximab.
Simvastatin	Simvastatin The metabolism of Simvastatin can be increased when combined with Siltuximab.
Epoetin Alfa, Injection	Epoetin Alfa, Injection The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Siltuximab.
Teniposide Injection	Teniposide Injection The metabolism of Teniposide can be increased when combined with Siltuximab.
Sotalol	Sotalol The metabolism of Sotalol can be increased when combined with Siltuximab.
Zolpidem	Zolpidem The metabolism of Zolpidem can be increased when combined with Siltuximab.
Doxazosin	Doxazosin The metabolism of Doxazosin can be increased when combined with Siltuximab.
Omeprazole	Omeprazole The metabolism of Omeprazole can be increased when combined with Siltuximab.
Cisapride	Cisapride The metabolism of Cisapride can be increased when combined with Siltuximab.
Fluvastatin	Fluvastatin The metabolism of Fluvastatin can be increased when combined with Siltuximab.
Venlafaxine	Venlafaxine The metabolism of Venlafaxine can be increased when combined with Siltuximab.
Famciclovir	Famciclovir The metabolism of Famciclovir can be increased when combined with Siltuximab.
Fluvoxamine	Fluvoxamine The metabolism of Fluvoxamine can be increased when combined with Siltuximab.
Nefazodone	Nefazodone The metabolism of Nefazodone can be increased when combined with Siltuximab.
Losartan	Losartan The metabolism of Losartan can be increased when combined with Siltuximab.
Tramadol	Tramadol The metabolism of Tramadol can be decreased when combined with Siltuximab.
Vinorelbine Injection	Vinorelbine Injection The metabolism of Siltuximab can be increased when combined with Vinorelbine.
Carboplatin Injection	Carboplatin Injection The risk or severity of adverse effects can be increased when Carboplatin is combined with Siltuximab.
Lansoprazole	Lansoprazole The metabolism of Lansoprazole can be increased when combined with Siltuximab.
Ifosfamide Injection	Ifosfamide Injection The metabolism of Ifosfamide can be increased when combined with Siltuximab.
Pegaspargase Injection	Pegaspargase Injection The risk or severity of adverse effects can be increased when Pegaspargase is combined with Siltuximab.
Nicardipine	Nicardipine The metabolism of Nicardipine can be increased when combined with Siltuximab.
Bupropion	Bupropion The metabolism of Bupropion can be increased when combined with Siltuximab.
Ticlopidine	Ticlopidine The metabolism of Ticlopidine can be increased when combined with Siltuximab.
Saquinavir	Saquinavir The metabolism of Saquinavir can be increased when combined with Siltuximab.
Nisoldipine	Nisoldipine The metabolism of Nisoldipine can be increased when combined with Siltuximab.
Riluzole	Riluzole The metabolism of Riluzole can be increased when combined with Siltuximab.
Glimepiride	Glimepiride The metabolism of Glimepiride can be increased when combined with Siltuximab.
Anastrozole	Anastrozole The metabolism of Anastrozole can be increased when combined with Siltuximab.
Gemcitabine Injection	Gemcitabine Injection The risk or severity of adverse effects can be increased when Gemcitabine is combined with Siltuximab.
Indinavir	Indinavir The metabolism of Indinavir can be increased when combined with Siltuximab.
Ritonavir	Ritonavir The metabolism of Ritonavir can be increased when combined with Siltuximab.
Docetaxel Injection	Docetaxel Injection The metabolism of Docetaxel can be increased when combined with Siltuximab.
Clomipramine	Clomipramine The metabolism of Clomipramine can be increased when combined with Siltuximab.
Zafirlukast	Zafirlukast The metabolism of Zafirlukast can be increased when combined with Siltuximab.
Mirtazapine	Mirtazapine The metabolism of Mirtazapine can be increased when combined with Siltuximab.
Zileuton	Zileuton The metabolism of Zileuton can be increased when combined with Siltuximab.
Valsartan	Valsartan The metabolism of Valsartan can be increased when combined with Siltuximab.
Donepezil	Donepezil The metabolism of Donepezil can be increased when combined with Siltuximab.
Azithromycin	Azithromycin The metabolism of Azithromycin can be increased when combined with Siltuximab.
Carvedilol	Carvedilol The metabolism of Carvedilol can be increased when combined with Siltuximab.
Flutamide	Flutamide The metabolism of Flutamide can be increased when combined with Siltuximab.
Selegiline	Selegiline The metabolism of Selegiline can be increased when combined with Siltuximab.
Bicalutamide	Bicalutamide The metabolism of Bicalutamide can be increased when combined with Siltuximab.
Sertraline	Sertraline The metabolism of Sertraline can be increased when combined with Siltuximab.
Propafenone	Propafenone The metabolism of Propafenone can be increased when combined with Siltuximab.
Letrozole	Letrozole The metabolism of Letrozole can be increased when combined with Siltuximab.
Irbesartan	Irbesartan The metabolism of Irbesartan can be increased when combined with Siltuximab.
Tamsulosin	Tamsulosin The metabolism of Tamsulosin can be increased when combined with Siltuximab.
Ropinirole	Ropinirole The metabolism of Ropinirole can be increased when combined with Siltuximab.
Finasteride	Finasteride The metabolism of Finasteride can be increased when combined with Siltuximab.
Quetiapine	Quetiapine The metabolism of Quetiapine can be increased when combined with Siltuximab.
Paroxetine	Paroxetine The metabolism of Paroxetine can be increased when combined with Siltuximab.
Palivizumab Injection	Palivizumab Injection The risk or severity of adverse effects can be increased when Palivizumab is combined with Siltuximab.
Citalopram	Citalopram The metabolism of Citalopram can be increased when combined with Siltuximab.
Capecitabine	Capecitabine The metabolism of Siltuximab can be increased when combined with Capecitabine.
Efavirenz	Efavirenz The metabolism of Efavirenz can be increased when combined with Siltuximab.
Sildenafil	Sildenafil The metabolism of Sildenafil can be increased when combined with Siltuximab.
Pioglitazone	Pioglitazone The metabolism of Pioglitazone can be increased when combined with Siltuximab.
Trastuzumab Injection	Trastuzumab Injection Trastuzumab may increase the neutropenic activities of Siltuximab.
Celecoxib	Celecoxib The metabolism of Celecoxib can be increased when combined with Siltuximab.
Rosiglitazone	Rosiglitazone The metabolism of Rosiglitazone can be increased when combined with Siltuximab.
Tolterodine	Tolterodine The metabolism of Tolterodine can be increased when combined with Siltuximab.
Thalidomide	Thalidomide The metabolism of Thalidomide can be increased when combined with Siltuximab.
Nateglinide	Nateglinide The metabolism of Nateglinide can be increased when combined with Siltuximab.
Galantamine	Galantamine The metabolism of Galantamine can be increased when combined with Siltuximab.
Rabeprazole	Rabeprazole The metabolism of Rabeprazole can be increased when combined with Siltuximab.
Terbinafine	Terbinafine The metabolism of Terbinafine can be increased when combined with Siltuximab.

Siltuximab Injection

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