FDA-filed SPL labeling · retrieved through openFDA

Tetrahydrozoline Ophthalmic

Tetrahydrozoline ophthalmic is an eye drop used to relieve redness caused by minor eye irritation.

Brand names Collyrium FreshMurine PlusOptigene 3VisineAltazine +11 more
OTC Form 1 Route Ophthalmic
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 31 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

At a glance
Linked label effectiveNov 13, 2024
Clinical labels in scope ⓘ31
AvailabilityOTC
Earliest approval/marketing year ⓘ1979
FDA-listed product records ⓘ67
Boxed warningNone found in compared labels
How we combine label and product data →
✓No current FDA shortage listed · checked Sep 24, 2026
⭐ Tetrahydrozoline Ophthalmic at a glance The quick version — the full detail is in the Patient Information Guide below.
💊
HelloPharmacist Editorial Team Bottom Line
Tetrahydrozoline ophthalmic eye drops are a straightforward, short-term option for relieving minor eye redness. Use only as directed — overuse can backfire and cause more redness. Stop use and check with a doctor if your symptoms don't improve within 72 hours or if you notice eye pain or vision changes.
How we write & review this content — our editorial policy →

📖 Tetrahydrozoline Ophthalmic: Patient Information Guide

A plain-language walkthrough of Tetrahydrozoline Ophthalmic — what it treats, how it works, how it’s taken, side effects, warnings and interactions. Tap any section to expand it.

🎯What it's used for▾

Tetrahydrozoline ophthalmic eye drops are used for one purpose: relieving eye redness from minor irritation.

  • Relief of redness of the eye due to minor eye irritations — available across brands including CAREALL Eyedrops Original, DG Original Eye Drops, Good Neighbor Pharmacy Eye Drops Original Formula, GoodSense Eye Drops Original Formula, Preferred Plus Pharmacy Redness Relief Eye Drops, and Redness reliever
💊How it's taken▾

Adults and children 6 years and older may place 1 or 2 drops into the affected eye(s) up to 4 times a day. Children under 6 should not use this product without first consulting a doctor, and children under 2 should not use it at all.

  • Always remove contact lenses before applying the drops
  • Do not touch the dropper tip to any surface to keep the solution sterile
  • Replace the cap after every use
  • Do not use a solution that has changed color or turned cloudy
🤒Side effects — in detail▾

Most people tolerate these drops well, but a few effects are worth knowing about:

  • Temporary enlargement of the pupils
  • Increased eye redness with overuse
  • Eye irritation

If you experience eye pain, vision changes, or redness that persists or worsens beyond 72 hours, stop using the drops and contact your doctor right away.

⚠️Warnings & precautions▾
  • For external (eye) use only — these drops should never be swallowed. If swallowed, call Poison Control at 1-800-222-1222 immediately.
  • Overuse can make eye redness worse, not better — stick to the recommended frequency.
  • If you have narrow angle glaucoma (a type of increased eye pressure), ask a doctor before using.
  • Pupils may temporarily enlarge while you use this product.
  • Do not use a solution that has changed color or appears cloudy.
  • Stop use and see a doctor if symptoms do not improve within 72 hours.
🔀What it interacts with▾

The label does not list specific drug interactions for these eye drops, but a few practical precautions apply:

  • Remove contact lenses before using — lenses can absorb the solution and may become contaminated

This is not a complete list of interactions. Always talk with your doctor or pharmacist before starting, stopping, or changing any medication.

📋Before taking it▾
  • Tell your doctor if you have narrow angle glaucoma before using
  • Ask a health professional before use if you are pregnant or breastfeeding
  • Children under 6 years: consult a doctor first
  • Children under 2 years: do not use
  • Contact lens wearers: remove lenses before applying drops
🚑If you take too much▾

If these drops are swallowed — especially by a child — it can be dangerous. Get medical help or contact Poison Control at 1-800-222-1222 right away. Keep the product stored out of reach of children at all times.

📦How to store it▾

Store at 20° to 25°C (68° to 77°F)

📄 Written from Tetrahydrozoline Ophthalmic’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Every point is grounded in that labeling — nothing is invented. How we use AI →

🩺 Pharmacist Counseling Corner

Quick, plain-English answers to the questions patients ask most about Tetrahydrozoline Ophthalmic — the kind of thing our pharmacy team would talk through with you at the counter.

What exactly does this eye drop do — does it actually fix what's irritating my eye? ▾
It relieves the redness you see, but it doesn't treat the underlying cause of the irritation. Think of it as a short-term fix to take the red out. If something is genuinely bothering your eye — like allergies, an infection, or a foreign object — you'll need to address that separately. If redness persists beyond 72 hours, check with your doctor.
Can I wear my contact lenses while using these drops? ▾
No — you should remove your contact lenses before putting in the drops. The solution can be absorbed by soft contacts, which can affect the lens and potentially irritate your eye. Once you've used the drops, wait before putting your lenses back in, and follow any guidance your eye care provider has given you.
I've been using these drops every day for a while. Is that okay? ▾
Actually, overusing redness-relief drops is something to be careful about. Using them too often can cause more eye redness — the opposite of what you want. These are meant for short-term use. If you're reaching for them daily or your eyes stay red, it's worth talking to your doctor to find out what's really going on.
My child's eyes are red — can I use these drops on them? ▾
It depends on their age. For children 6 and older, you can use 1 or 2 drops up to 4 times a day — same as adults. For children under 6, talk to a doctor first before using. And for children under 2, do not use this product at all. Also, keep the bottle well out of reach — if swallowed, call Poison Control at 1-800-222-1222 right away.
I noticed my pupils look bigger after using the drops. Should I be worried? ▾
That's a known, temporary effect of these drops — your pupils may enlarge for a short time after use. It's listed on the label and usually harmless. That said, if you also notice eye pain or changes in your vision along with it, stop using the drops and see a doctor.
I'm pregnant — is it safe to use these eye drops? ▾
The label says to ask a health professional before using if you're pregnant or breastfeeding. It's always a good idea to check with your doctor or midwife before using any medication during pregnancy, even an over-the-counter eye drop. They can help you weigh the benefits and any potential concerns.
Is Tetrahydrozoline Ophthalmic available over the counter? ▾
Yes — Tetrahydrozoline Ophthalmic is available over the counter (without a prescription) in at least some forms, according to its FDA labeling. Follow the package directions and ask your pharmacist if you're unsure which product is right for you.
When was Tetrahydrozoline Ophthalmic first available? ▾
Tetrahydrozoline Ophthalmic has been available in the United States since at least 1979, based on FDA approval history (Drugs@FDA) and product marketing records.
Who makes Tetrahydrozoline Ophthalmic? ▾
Tetrahydrozoline Ophthalmic is supplied by 34 manufacturers listed in the FDA NDC Directory, including Strategic Sourcing Services LLC, Kinray, WinCo Foods, LLC.

💬 Answers drafted from Tetrahydrozoline Ophthalmic’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Grounded in that labeling — nothing is made up. How we use AI →

🧰 Keep exploring

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💊 How Tetrahydrozoline Ophthalmic comes

Tetrahydrozoline Ophthalmic is available in 1 form. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Eye drops

In the eye
Brands CAREALL Eyedrops Original DG Original Eye Drops Good Neighbor Pharmacy Eye Drops Original Formula GoodSense Eye Drops Original Formula Preferred Plus Pharmacy Redness Relief Eye Drops Redness reliever Visine Red Eye Comfort Walgreens Eye Drops Original 15mL and twin pack Winco Original Formula Eye Drops
How this form is used
What it may be used for
  • Used to relieve redness of the eye due to minor eye irritations
Important instructions
  • Adults and children 6 and over: place 1 or 2 drops in the affected eye(s) up to 4 times a day
  • Remove contact lenses before applying drops
  • Do not touch the dropper tip to any surface; replace the cap after each use
  • Do not use if the solution has changed color or become cloudy
Available strengths 3 strengths
0.05 mg/mL 0.5 mg/mL 0.05 g/100 mL
67 FDA-listed product records ⓘ

📊 Tetrahydrozoline Ophthalmic across the U.S. market

How Tetrahydrozoline Ophthalmic appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

1
Dose forms ⓘ
34
Manufacturers
37
Brand names
67
FDA-listed product records ⓘ
1979
First marketed ⓘ
Strategic Sourcing Services LLC9%
Kinray4%
WinCo Foods, LLC4%
New World Imports, Inc4%
Lil' Drug Store products, Inc.4%
Geiss, Destin & Dunn, Inc.4%
Other makers69%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

📈 How widely Tetrahydrozoline Ophthalmic is used

A general measure of how commonly Tetrahydrozoline Ophthalmic is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Tetrahydrozoline Ophthalmic is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

13
Medicaid prescriptions filled (Q1–Q4 2025)
$53 gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Tetrahydrozoline Ophthalmic prescribed? Of the 1,596 medications we measure, Tetrahydrozoline Ophthalmic ranks #1,580 by Medicaid prescriptions — more than 1% of them.

Where Tetrahydrozoline Ophthalmic ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #1,580 of 1,596
#1,575 Mosunetuzumab-axgb Inj... 15 Rx #1,576 Acetaminophen / Ibupro... 15 Rx #1,577 Hyaluronidase / Ocreli... 15 Rx #1,578 Artemether and Lumefan... 14 Rx #1,579 Phenoxybenzamine 14 Rx #1,580 Siltuximab Injection 13 Rx #1,581 Phenytoin Injection 13 Rx #1,582 Dactinomycin 13 Rx #1,583 Tetrahydrozoline Ophth... 13 Rx #1,584 Papaverine 13 Rx #1,585 Pacritinib 13 Rx

Utilization by Tetrahydrozoline Ophthalmic product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

tetrahydrozoline hydrochloride 0.5 MG/ML Ophthalmic Solution

13 Medicaid prescriptions (Q1–Q4 2025) 100% of Tetrahydrozoline Ophthalmic prescriptions shown $53 gross reimbursement (before rebates) ≈ $4.05 per prescription (gross)

Summed across the 1 of 52 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1052943

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Tetrahydrozoline Ophthalmic, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 1 of 52 listed Tetrahydrozoline Ophthalmic NDCs with Medicaid activity.

🔍 Compare Tetrahydrozoline Ophthalmic products

A representative set of FDA-listed product records for Tetrahydrozoline Ophthalmic — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 67 of 67 products — FDA National Drug Code Directory. See every product, package size and price: browse all 67 Tetrahydrozoline Ophthalmic NDCs →

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Tetrahydrozoline Ophthalmic RxCUI 37935 2 dose forms · 2 strengths
  1. Dose form (SCDF) Nasal Solution RxCUI 377447 No current FDA listing
    Clinical drug / strength (SCD) hydrochloride 0.5 MG/ML RxCUI 1232712
  2. Dose form (SCDF) Ophthalmic Solution RxCUI 374067 In current FDA listings
    Clinical drug / strength (SCD) hydrochloride 0.5 MG/ML RxCUI 1052943

Look up RxCUI 37935 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

🏷️ Sold under these brand names

Collyrium Fresh Murine Plus Optigene 3 Visine Altazine Optigene Redness reliever CAREALL Eyedrops Original Winco Original Formula Eye Drops Visine Red Eye Comfort Preferred Plus Pharmacy Redness Relief Eye Drops GoodSense Eye Drops Original Formula Good Neighbor Pharmacy Eye Drops Original Formula DG Original Eye Drops Walgreens Eye Drops Original 15mL and twin pack Meijer Redness Relief

🏭 Manufacturers & labelers

Strategic Sourcing Services LLC 6 Kinray 3 WinCo Foods, LLC 3 New World Imports, Inc 3 Lil' Drug Store products, Inc. 3 Geiss, Destin & Dunn, Inc. 3 Dolgencorp LLC 3 AmerisourceBergen Drug Corporation 3 Family Dollar Services, Inc. 2 Walmart, Inc. 2 Walgreens Company 2 United Exchange Corp 2 Topco Associates LLC 2 Cardinal Health 2 Rugby Laboratories 2 Rite Aid Corporation 2 Meijer Distribution, Inc. 2 KC Pharmaceuticals, Inc. 2 Kareway Product, Inc. 2 Johnson & Johnson Consumer Inc. 2 American Sales Company 2 Honeywell Safety Products USA, INC 2 The Kroger Co. 1 Dolgencorp Inc 1

…and 10 more on the FDA NDC directory.

RxNorm drug class

Tetrahydrozoline Ophthalmic belongs to the Sympathomimetics, plain class.

Drug family (ATC) Sympathomimetics, plain, Sympathomimetics used as decongestants

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

🔬 Where this comes from

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Nov 13, 2024
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Tetrahydrozoline Ophthalmic.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Tetrahydrozoline Ophthalmic after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
31
NDC products indexed
67
Distinct labelers/manufacturers represented
34
Linked representative label ⓘ
Kenvue Brands LLC
Linked label effective
Nov 13, 2024
Composite sections available
7
Linked SPL Set ID
d7abd7cb-e094-481f-bea5-a5983e2c9ef4
Linked SPL Document ID
21d6bf1e-40c6-2b49-e063-6294a90a3ede
Open the linked representative label on DailyMed ↗

How we combine label and product data

HelloPharmacist combines public FDA and NLM records; we don’t author the underlying clinical facts. We identified 31 FDA-filed SPL label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. The representative label is the starting point for the displayed reference monograph; the 12 largest stored in-scope SPL records, which may include that representative, are compared section by section, and the longest available version of each section is retained. Forms, routes, brands, labelers, product-listed strengths, and product-record counts are aggregated separately from ingredient-matched FDA NDC Directory records; package records listed above are associated with the linked SPL; and the normalized concept hierarchy comes from NLM RxNorm.

Where a section is identified as AI-written, its plain-language text is generated from bounded label evidence. New draft drug pages remain in the admin review queue before first publication. Kenvue Brands LLC is the representative DailyMed label linked for verification and dates; it is not the sole source used for the page.

This is general education, not medical advice — always consult your doctor or pharmacist about your medications and any medical condition. For the exact wording of the linked representative label, view that label on DailyMed; some displayed composite sections may come from other in-scope SPL labels. Learn how we use AI and our data sources & update cadence.