Cobimetinib

Generic name: Pronounced as (koe" bi me' ti nib)
Brand names
  • Cotellic®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 12/15/2015

Cobimetinib is used along with vemurafenib (Zelboraf) to treat certain types of melanoma (a type of skin cancer) that cannot be treated with surgery or that has spread to other parts of the body. Cobimetinib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps slow or stop the spread of cancer cells.

Cobimetinib comes as a tablet to take by mouth with or without food. It is usually taken once daily for the first 21 days of a 28-day cycle. Take cobimetinib at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take cobimetinib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

If you vomit after taking cobimetinib do not take another dose. Continue your regular dosing schedule.

Your doctor may decrease your dose of cobimetinib or permanently or temporarily stop your treatment. This depends on how well the medication works for you and the side effects you experience. Be sure to tell your doctor how you are feeling during your treatment with cobimetinib.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking cobimetinib,

  • tell your doctor and pharmacist if you are allergic to cobimetinib, any other medications, or any of the ingredients in cobimetinib tablets. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: anticoagulants (blood thinners) such as warfarin (Coumadin, Jantoven), carbamazepine (Carbatrol, Epitol, Tegretol), ciprofloxacin (Cipro), clarithromycin (Biaxin, in Prevpac), efavirenz (Sustiva, in Atripla), erythromycin (E.E.S., E-Mycin, Erythrocin), indinavir (Crixivan), itraconazole (Onmel, Sporanox), ketoconazole (Extina, Ketozole, Nizoral), nefazodone, nelfinavir (Viracept), phenytoin (Dilantin, Phenytek), rifampin (Rifadin, Rimactane, in Rifamate, in Rifater), and ritonavir (Norvir, in Kaletra, in Viekira Pak). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with cobimetinib, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

  • tell your doctor what herbal products you are taking, especially St. John's Wort. Do not take St. John's Wort while you are taking cobimetinib.

  • tell your doctor if you have or have ever had have skin conditions other than melanoma; bleeding problems; vision problems; any condition that affects your muscles; or heart or liver disease.

  • you should know that cobimetinib may decrease fertility in men and women. However, you should not assume that you or your partner cannot become pregnant. Tell your doctor if you are pregnant or plan to become pregnant. Use a reliable method of birth control to prevent pregnancy during your treatment and for 2 weeks after you stop taking cobimetinib. Talk to your doctor about birth control methods that will work for you. If you become pregnant while taking cobimetinib, call your doctor immediately. Cobimetinib may harm the fetus.

  • tell your doctor if you are breastfeeding. You should not breastfeed while taking cobimetinib and for 2 weeks after your last dose.

  • plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, lip balm and sunscreen (SPF 30 or higher). Cobimetinib may make your skin sensitive to sunlight.

Do not eat grapefruit or drink grapefruit juice while taking this medication.

Skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Cobimetinib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • mouth ulcers

    • hair loss

    • diarrhea

  • Some side effects can be serious. If you experience any of these symptoms or those in the SPECIAL PRECAUTIONS section, call your doctor immediately or get emergency medical treatment:

    • rash that covers a large area of your body, blisters, or peeling skin

    • changes in skin appearance

    • new wart

    • skin sore or red bump that bleeds or does not heal

    • change in size or color of a mole

    • unusual bleeding or bruising

    • tarry or black stools

    • blood in the urine

    • unusual vaginal bleeding

    • headache

    • dizziness

    • rapid, irregular, or pounding heartbeat

    • coughing or wheezing

    • shortness of breath

    • swelling of the face, arms, legs, ankles, or feet

    • tiredness

    • muscle pain or weakness

    • change in vision, including seeing halos (blurred outline around objects)

    • yellowing of the skin or eyes

    • dark-colored (tea-colored) urine

    • pain in upper right part of the stomach

    • nausea

    • vomiting

    • loss of appetite

  • Cobimetinib may increase the risk that you will develop new skin cancers. Talk to your doctor about the risks of taking this medication.

  • Cobimetinib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response during and after therapy. Your doctor will check your skin for any changes before, every 2 months during your treatment, and for up to 6 months after treatment.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Delavirdine Delavirdine The metabolism of Cobimetinib can be decreased when combined with Delavirdine.
Atorvastatin Atorvastatin The excretion of Cobimetinib can be decreased when combined with Atorvastatin.
Aminophylline Aminophylline The metabolism of Aminophylline can be decreased when combined with Cobimetinib.
Candesartan Candesartan The excretion of Cobimetinib can be decreased when combined with Candesartan.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The metabolism of Cobimetinib can be decreased when combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) The excretion of Cobimetinib can be decreased when combined with Conjugated estrogens.
Fenofibrate Fenofibrate The metabolism of Cobimetinib can be decreased when combined with Fenofibrate.
Methylergonovine Methylergonovine The metabolism of Cobimetinib can be decreased when combined with Methylergometrine.
Paregoric Paregoric The serum concentration of Cobimetinib can be increased when it is combined with Morphine.
Reserpine Reserpine The serum concentration of Cobimetinib can be increased when it is combined with Reserpine.
Tacrolimus Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Cobimetinib.
Triamcinolone Triamcinolone The metabolism of Cobimetinib can be increased when combined with Triamcinolone.
Doxycycline Injection Doxycycline Injection The metabolism of Cobimetinib can be decreased when combined with Doxycycline.
Fluconazole Injection Fluconazole Injection The metabolism of Cobimetinib can be decreased when combined with Fluconazole.
Meperidine Injection Meperidine Injection The metabolism of Cobimetinib can be increased when combined with Meperidine.
Methylprednisolone Injection Methylprednisolone Injection The metabolism of Cobimetinib can be increased when combined with Methylprednisolone.
Metronidazole Injection Metronidazole Injection The metabolism of Cobimetinib can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection The serum concentration of Cobimetinib can be increased when it is combined with Morphine.
Cyclosporine Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Cobimetinib.
Dofetilide Dofetilide The metabolism of Dofetilide can be decreased when combined with Cobimetinib.
Orlistat Orlistat The metabolism of Cobimetinib can be increased when combined with Orlistat.
Oxcarbazepine Oxcarbazepine The metabolism of Cobimetinib can be increased when combined with Oxcarbazepine.
Pantoprazole Pantoprazole The excretion of Cobimetinib can be decreased when combined with Pantoprazole.
Anakinra Anakinra The metabolism of Cobimetinib can be increased when combined with Anakinra.
Trimipramine Trimipramine The serum concentration of Trimipramine can be increased when it is combined with Cobimetinib.
Etanercept Injection Etanercept Injection The metabolism of Cobimetinib can be increased when combined with Etanercept.
Modafinil Modafinil The metabolism of Cobimetinib can be increased when combined with Modafinil.
Tenofovir Tenofovir The metabolism of Tenofovir can be decreased when combined with Cobimetinib.
Sirolimus Sirolimus The metabolism of Sirolimus can be decreased when combined with Cobimetinib.
Epinephrine Injection Epinephrine Injection The metabolism of Cobimetinib can be decreased when combined with Epinephrine.
Zonisamide Zonisamide The serum concentration of Cobimetinib can be increased when it is combined with Zonisamide.
Adalimumab Injection Adalimumab Injection The metabolism of Cobimetinib can be increased when combined with Adalimumab.
Atazanavir Atazanavir The metabolism of Cobimetinib can be decreased when combined with Atazanavir.
Mefloquine Mefloquine The metabolism of Cobimetinib can be decreased when combined with Mefloquine.
Rosuvastatin Rosuvastatin The metabolism of Cobimetinib can be decreased when combined with Rosuvastatin.
Vardenafil Vardenafil The serum concentration of Cobimetinib can be increased when it is combined with Vardenafil.
Aprepitant Aprepitant The metabolism of Aprepitant can be decreased when combined with Cobimetinib.
Tegaserod Tegaserod The serum concentration of Cobimetinib can be increased when it is combined with Tegaserod.
Progesterone Progesterone The metabolism of Cobimetinib can be increased when combined with Progesterone.
Darbepoetin Alfa Injection Darbepoetin Alfa Injection The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Cobimetinib.
Infliximab Injection Infliximab Injection The metabolism of Cobimetinib can be increased when combined with Infliximab.
Rifaximin Rifaximin The metabolism of Cobimetinib can be increased when combined with Rifaximin.
Duloxetine Duloxetine The metabolism of Cobimetinib can be decreased when combined with Duloxetine.
Norethindrone Norethindrone The metabolism of Cobimetinib can be decreased when combined with Norethisterone.
Bosentan Bosentan The metabolism of Cobimetinib can be increased when combined with Bosentan.
Erlotinib Erlotinib The metabolism of Cobimetinib can be decreased when combined with Erlotinib.
Voriconazole Voriconazole The metabolism of Cobimetinib can be decreased when combined with Voriconazole.
Deferasirox Deferasirox The metabolism of Cobimetinib can be increased when combined with Deferasirox.
Tipranavir Tipranavir The serum concentration of Tipranavir can be increased when it is combined with Cobimetinib.
Felbamate Felbamate The metabolism of Cobimetinib can be increased when combined with Felbamate.
Ranolazine Ranolazine The serum concentration of Cobimetinib can be increased when it is combined with Ranolazine.
Abatacept Injection Abatacept Injection The metabolism of Cobimetinib can be increased when combined with Abatacept.
Imatinib Imatinib The metabolism of Cobimetinib can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin The serum concentration of Cobimetinib can be increased when it is combined with Sitagliptin.
Gefitinib Gefitinib The metabolism of Cobimetinib can be decreased when combined with Gefitinib.
Paliperidone Paliperidone The serum concentration of Cobimetinib can be increased when it is combined with Paliperidone.
Bortezomib Bortezomib The metabolism of Bortezomib can be decreased when combined with Cobimetinib.
Posaconazole Posaconazole The metabolism of Cobimetinib can be decreased when combined with Posaconazole.
Primaquine Primaquine The metabolism of Cobimetinib can be decreased when combined with Primaquine.
Darunavir Darunavir The serum concentration of Darunavir can be increased when it is combined with Cobimetinib.
Sorafenib Sorafenib The serum concentration of Cobimetinib can be increased when it is combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Cobimetinib can be decreased when combined with Sunitinib.
Lapatinib Lapatinib The serum concentration of Cobimetinib can be increased when it is combined with Lapatinib.
Dasatinib Dasatinib The metabolism of Dasatinib can be decreased when combined with Cobimetinib.
Armodafinil Armodafinil The metabolism of Cobimetinib can be increased when combined with Armodafinil.
Ivermectin Ivermectin The metabolism of Cobimetinib can be increased when combined with Ivermectin.
Temsirolimus Temsirolimus The serum concentration of Temsirolimus can be increased when it is combined with Cobimetinib.
Nilotinib Nilotinib The serum concentration of Cobimetinib can be increased when it is combined with Nilotinib.
Toremifene Toremifene The serum concentration of Cobimetinib can be increased when it is combined with Toremifene.
Bexarotene Bexarotene The metabolism of Cobimetinib can be increased when combined with Bexarotene.
Budesonide Budesonide The metabolism of Cobimetinib can be increased when combined with Budesonide.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Cobimetinib can be decreased when combined with Chloramphenicol.
Etravirine Etravirine The metabolism of Cobimetinib can be increased when combined with Etravirine.
Mitoxantrone Injection Mitoxantrone Injection The metabolism of Cobimetinib can be decreased when combined with Mitoxantrone.
Desvenlafaxine Desvenlafaxine The metabolism of Cobimetinib can be decreased when combined with Desvenlafaxine.
Bendamustine Injection Bendamustine Injection The serum concentration of Bendamustine can be increased when it is combined with Cobimetinib.
Pilocarpine Pilocarpine The metabolism of Cobimetinib can be decreased when combined with Pilocarpine.
Certolizumab Injection Certolizumab Injection The metabolism of Cobimetinib can be increased when combined with Certolizumab pegol.
Ixabepilone Injection Ixabepilone Injection The metabolism of Ixabepilone can be decreased when combined with Cobimetinib.
Irinotecan Injection Irinotecan Injection The metabolism of Cobimetinib can be decreased when combined with Irinotecan.
Mitotane Mitotane The metabolism of Cobimetinib can be increased when combined with Mitotane.
Rufinamide Rufinamide The metabolism of Cobimetinib can be increased when combined with Rufinamide.
Silodosin Silodosin The serum concentration of Silodosin can be increased when it is combined with Cobimetinib.
Midazolam Midazolam The metabolism of Cobimetinib can be decreased when combined with Midazolam.
Eltrombopag Eltrombopag The excretion of Cobimetinib can be decreased when combined with Eltrombopag.
Milnacipran Milnacipran The metabolism of Cobimetinib can be decreased when combined with Milnacipran.
Lacosamide Lacosamide The metabolism of Lacosamide can be decreased when combined with Cobimetinib.
Everolimus Everolimus The metabolism of Everolimus can be decreased when combined with Cobimetinib.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The metabolism of Tolvaptan can be decreased when combined with Cobimetinib.
Dronedarone Dronedarone The metabolism of Dronedarone can be decreased when combined with Cobimetinib.
Romidepsin Injection Romidepsin Injection The metabolism of Romidepsin can be decreased when combined with Cobimetinib.
Topotecan Topotecan The metabolism of Cobimetinib can be increased when combined with Topotecan.
Golimumab Injection Golimumab Injection The metabolism of Cobimetinib can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Pazopanib can be decreased when combined with Cobimetinib.
Pitavastatin Pitavastatin The excretion of Cobimetinib can be decreased when combined with Pitavastatin.
Albendazole Albendazole The metabolism of Cobimetinib can be decreased when combined with Albendazole.
Tocilizumab Injection Tocilizumab Injection The metabolism of Cobimetinib can be increased when combined with Tocilizumab.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Cobimetinib can be decreased when combined with Cabazitaxel.
Acetaminophen Injection Acetaminophen Injection The metabolism of Cobimetinib can be increased when combined with Acetaminophen.
Denileukin Diftitox Injection Denileukin Diftitox Injection The metabolism of Cobimetinib can be decreased when combined with Aldesleukin.
Busulfan Injection Busulfan Injection The metabolism of Busulfan can be decreased when combined with Cobimetinib.
Roflumilast Roflumilast The metabolism of Cobimetinib can be decreased when combined with Roflumilast.
Linagliptin Linagliptin The metabolism of Cobimetinib can be decreased when combined with Linagliptin.
Rilpivirine Rilpivirine The metabolism of Cobimetinib can be decreased when combined with Rilpivirine.
Telaprevir Telaprevir The serum concentration of Cobimetinib can be increased when it is combined with Glecaprevir.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Cobimetinib can be increased when combined with Cyclophosphamide.
Rivaroxaban Rivaroxaban The serum concentration of Rivaroxaban can be increased when it is combined with Cobimetinib.
Ticagrelor Ticagrelor The serum concentration of Cobimetinib can be increased when it is combined with Ticagrelor.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Cobimetinib can be decreased when combined with Brentuximab vedotin.
Ruxolitinib Ruxolitinib The metabolism of Ruxolitinib can be decreased when combined with Cobimetinib.
Vandetanib Vandetanib The serum concentration of Cobimetinib can be increased when it is combined with Vandetanib.
Clobazam Clobazam The metabolism of Cobimetinib can be increased when combined with Clobazam.
Vemurafenib Vemurafenib The serum concentration of Cobimetinib can be increased when it is combined with Vemurafenib.
Ivacaftor Ivacaftor The serum concentration of Cobimetinib can be increased when it is combined with Ivacaftor.
Axitinib Axitinib The metabolism of Cobimetinib can be decreased when combined with Axitinib.
Crizotinib Crizotinib The metabolism of Cobimetinib can be decreased when combined with Crizotinib.
Cabergoline Cabergoline The metabolism of Cobimetinib can be decreased when combined with Cabergoline.
Naloxone Injection Naloxone Injection The metabolism of Cobimetinib can be decreased when combined with Naloxone.
Ambrisentan Ambrisentan The serum concentration of Ambrisentan can be increased when it is combined with Cobimetinib.
Carfilzomib Injection Carfilzomib Injection The serum concentration of Cobimetinib can be increased when it is combined with Carfilzomib.
Enzalutamide Enzalutamide The serum concentration of Cobimetinib can be increased when it is combined with Enzalutamide.
Mirabegron Mirabegron The serum concentration of Mirabegron can be increased when it is combined with Cobimetinib.
Regorafenib Regorafenib The serum concentration of Cobimetinib can be increased when it is combined with Regorafenib.
Bosutinib Bosutinib The metabolism of Cobimetinib can be decreased when combined with Bosutinib.
Corticotropin, Repository Injection Corticotropin, Repository Injection The metabolism of Cobimetinib can be increased when combined with Corticotropin.
Teriflunomide Teriflunomide The excretion of Cobimetinib can be decreased when combined with Teriflunomide.
Ponatinib Ponatinib The serum concentration of Cobimetinib can be increased when it is combined with Ponatinib.
Pomalidomide Pomalidomide The metabolism of Pomalidomide can be decreased when combined with Cobimetinib.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be decreased when combined with Cobimetinib.
Apixaban Apixaban The serum concentration of Apixaban can be increased when it is combined with Cobimetinib.
Canagliflozin Canagliflozin The serum concentration of Cobimetinib can be increased when it is combined with Canagliflozin.
Dabrafenib Dabrafenib The metabolism of Dabrafenib can be increased when combined with Cobimetinib.
Trametinib Trametinib The metabolism of Cobimetinib can be increased when combined with Trametinib.
Dolutegravir Dolutegravir The serum concentration of Dolutegravir can be increased when it is combined with Cobimetinib.
Afatinib Afatinib The serum concentration of Cobimetinib can be increased when it is combined with Afatinib.
Perampanel Perampanel The metabolism of Cobimetinib can be increased when combined with Perampanel.
Lomitapide Lomitapide The serum concentration of Cobimetinib can be increased when it is combined with Lomitapide.
Simeprevir Simeprevir The metabolism of Cobimetinib can be decreased when combined with Simeprevir.
Sofosbuvir Sofosbuvir The serum concentration of Sofosbuvir can be increased when it is combined with Cobimetinib.
Apremilast Apremilast The metabolism of Cobimetinib can be increased when combined with Apremilast.
Ceritinib Ceritinib The metabolism of Ceritinib can be decreased when combined with Cobimetinib.
Siltuximab Injection Siltuximab Injection The metabolism of Cobimetinib can be increased when combined with Siltuximab.
Eslicarbazepine Eslicarbazepine The metabolism of Cobimetinib can be increased when combined with Eslicarbazepine.
Belinostat Injection Belinostat Injection The serum concentration of Cobimetinib can be increased when it is combined with Belinostat.
Idelalisib Idelalisib The metabolism of Idelalisib can be decreased when combined with Cobimetinib.
Testosterone Injection Testosterone Injection The metabolism of Cobimetinib can be increased when combined with Testosterone.
Oritavancin Injection Oritavancin Injection The metabolism of Cobimetinib can be increased when combined with Oritavancin.
Vorapaxar Vorapaxar The serum concentration of Cobimetinib can be increased when it is combined with Vorapaxar.
Suvorexant Suvorexant The serum concentration of Cobimetinib can be increased when it is combined with Suvorexant.
Edoxaban Edoxaban The serum concentration of Edoxaban can be increased when it is combined with Cobimetinib.
Olaparib Olaparib The metabolism of Cobimetinib can be decreased when combined with Olaparib.
Caspofungin Injection Caspofungin Injection The excretion of Cobimetinib can be decreased when combined with Caspofungin.
Tasimelteon Tasimelteon The metabolism of Tasimelteon can be decreased when combined with Cobimetinib.
Lanreotide Injection Lanreotide Injection The metabolism of Cobimetinib can be decreased when combined with Lanreotide.
Nintedanib Nintedanib The metabolism of Nintedanib can be decreased when combined with Cobimetinib.
Secukinumab Injection Secukinumab Injection The metabolism of Cobimetinib can be increased when combined with Secukinumab.
Palbociclib Palbociclib The serum concentration of Cobimetinib can be increased when it is combined with Palbociclib.
Lenvatinib Lenvatinib The metabolism of Lenvatinib can be increased when combined with Cobimetinib.
Panobinostat Panobinostat The metabolism of Panobinostat can be decreased when combined with Cobimetinib.
Haloperidol Injection Haloperidol Injection The metabolism of Cobimetinib can be decreased when combined with Haloperidol.
Isavuconazonium Injection Isavuconazonium Injection The metabolism of Cobimetinib can be decreased when combined with Isavuconazonium.
Sonidegib Sonidegib The metabolism of Sonidegib can be decreased when combined with Cobimetinib.
Flibanserin Flibanserin The serum concentration of Cobimetinib can be increased when it is combined with Flibanserin.
Rolapitant Rolapitant The serum concentration of Cobimetinib can be increased when it is combined with Rolapitant.
Prednisolone Prednisolone The metabolism of Cobimetinib can be increased when combined with Prednisolone.
Daclatasvir Daclatasvir The serum concentration of Cobimetinib can be increased when it is combined with Daclatasvir.
Ziprasidone Injection Ziprasidone Injection The metabolism of Cobimetinib can be decreased when combined with Ziprasidone.
Eluxadoline Eluxadoline The excretion of Cobimetinib can be decreased when combined with Eluxadoline.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Cobimetinib.
Osimertinib Osimertinib The metabolism of Osimertinib can be increased when combined with Cobimetinib.
Alectinib Alectinib The metabolism of Alectinib can be decreased when combined with Cobimetinib.
Ixazomib Ixazomib The metabolism of Ixazomib can be decreased when combined with Cobimetinib.
Rifapentine Rifapentine The metabolism of Cobimetinib can be increased when combined with Rifapentine.
Lesinurad Lesinurad The metabolism of Cobimetinib can be increased when combined with Lesinurad.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The metabolism of Cobimetinib can be decreased when combined with Amphotericin B.
Dexamethasone Injection Dexamethasone Injection The metabolism of Cobimetinib can be increased when combined with Dexamethasone.
Venetoclax Venetoclax The metabolism of Cobimetinib can be decreased when combined with Venetoclax.
Cobicistat Cobicistat The serum concentration of Cobimetinib can be increased when it is combined with Cobicistat.
Selexipag Selexipag The serum concentration of Selexipag can be increased when it is combined with Cobimetinib.
Rucaparib Rucaparib The serum concentration of Cobimetinib can be increased when it is combined with Rucaparib.
Ribociclib Ribociclib The metabolism of Cobimetinib can be decreased when combined with Ribociclib.
Brigatinib Brigatinib The metabolism of Cobimetinib can be increased when combined with Brigatinib.
Deflazacort Deflazacort The metabolism of Cobimetinib can be increased when combined with Deflazacort.
Sarilumab Injection Sarilumab Injection The metabolism of Cobimetinib can be increased when combined with Sarilumab.
Midostaurin Midostaurin The metabolism of Cobimetinib can be increased when combined with Midostaurin.
Neratinib Neratinib The serum concentration of Cobimetinib can be increased when it is combined with Neratinib.
Enasidenib Enasidenib The serum concentration of Cobimetinib can be increased when it is combined with Enasidenib.
Inotuzumab Ozogamicin Injection Inotuzumab Ozogamicin Injection The serum concentration of Inotuzumab ozogamicin can be increased when it is combined with Cobimetinib.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Cobimetinib can be increased when combined with Fosaprepitant.
Copanlisib Injection Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Cobimetinib.
Abemaciclib Abemaciclib The metabolism of Abemaciclib can be decreased when combined with Cobimetinib.
Betrixaban Betrixaban The serum concentration of Betrixaban can be increased when it is combined with Cobimetinib.
Acalabrutinib Acalabrutinib The metabolism of Cobimetinib can be decreased when combined with Acalabrutinib.
Letermovir Letermovir The metabolism of Cobimetinib can be decreased when combined with Letermovir.
Ertugliflozin Ertugliflozin The serum concentration of Ertugliflozin can be increased when it is combined with Cobimetinib.
Buprenorphine Injection Buprenorphine Injection The metabolism of Cobimetinib can be decreased when combined with Buprenorphine.
Apalutamide Apalutamide The serum concentration of Cobimetinib can be decreased when it is combined with Apalutamide.
Fostamatinib Fostamatinib The metabolism of Cobimetinib can be decreased when combined with Fostamatinib.
Avatrombopag Avatrombopag The serum concentration of Avatrombopag can be increased when it is combined with Cobimetinib.
Baricitinib Baricitinib The metabolism of Baricitinib can be decreased when combined with Cobimetinib.
Eliglustat Eliglustat The serum concentration of Eliglustat can be increased when it is combined with Cobimetinib.
Binimetinib Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Cobimetinib.
Ivosidenib Ivosidenib The serum concentration of Cobimetinib can be increased when it is combined with Ivosidenib.
Lusutrombopag Lusutrombopag The serum concentration of Lusutrombopag can be increased when it is combined with Cobimetinib.
Elagolix Elagolix The serum concentration of Elagolix can be increased when it is combined with Cobimetinib.
Dacomitinib Dacomitinib The serum concentration of Cobimetinib can be increased when it is combined with Dacomitinib.
Duvelisib Duvelisib The metabolism of Duvelisib can be decreased when combined with Cobimetinib.
Omadacycline Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Cobimetinib.
Sarecycline Sarecycline The serum concentration of Cobimetinib can be increased when it is combined with Sarecycline.
Stiripentol Stiripentol The metabolism of Cobimetinib can be decreased when combined with Stiripentol.
Talazoparib Talazoparib The serum concentration of Talazoparib can be increased when it is combined with Cobimetinib.
Gilteritinib Gilteritinib The metabolism of Gilteritinib can be decreased when combined with Cobimetinib.
Glasdegib Glasdegib The serum concentration of Cobimetinib can be increased when it is combined with Glasdegib.
Larotrectinib Larotrectinib The serum concentration of Larotrectinib can be increased when it is combined with Cobimetinib.
Methoxy Polyethylene Glycol-Epoetin Beta Injection Methoxy Polyethylene Glycol-Epoetin Beta Injection The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Cobimetinib.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be increased when combined with Cobimetinib.
Rifamycin Rifamycin The serum concentration of Cobimetinib can be increased when it is combined with Rifamycin.
Prucalopride Prucalopride The metabolism of Prucalopride can be decreased when combined with Cobimetinib.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Cobimetinib can be increased when combined with Emapalumab.
Siponimod Siponimod The metabolism of Siponimod can be decreased when combined with Cobimetinib.
Erdafitinib Erdafitinib The serum concentration of Cobimetinib can be increased when it is combined with Erdafitinib.
Alpelisib Alpelisib The metabolism of Cobimetinib can be increased when combined with Alpelisib.
Selinexor Selinexor The excretion of Cobimetinib can be decreased when combined with Selinexor.
Darolutamide Darolutamide The serum concentration of Darolutamide can be increased when it is combined with Cobimetinib.
Triclabendazole Triclabendazole The metabolism of Cobimetinib can be decreased when combined with Triclabendazole.
Entrectinib Entrectinib The serum concentration of Cobimetinib can be increased when it is combined with Entrectinib.
Pexidartinib Pexidartinib The metabolism of Cobimetinib can be decreased when combined with Pexidartinib.
Istradefylline Istradefylline The serum concentration of Cobimetinib can be increased when it is combined with Istradefylline.
Pitolisant Pitolisant The serum concentration of Cobimetinib can be decreased when it is combined with Pitolisant.
Fedratinib Fedratinib The serum concentration of Cobimetinib can be increased when it is combined with Fedratinib.
Lefamulin Lefamulin The serum concentration of Lefamulin can be increased when it is combined with Cobimetinib.
Phenytoin Injection Phenytoin Injection The metabolism of Cobimetinib can be increased when combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Cobimetinib can be increased when combined with Fosphenytoin.
Enfortumab vedotin-ejfv Injection Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be increased when it is combined with Cobimetinib.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Cobimetinib.
Voxelotor Voxelotor The serum concentration of Cobimetinib can be increased when it is combined with Voxelotor.
Lasmiditan Lasmiditan The serum concentration of Cobimetinib can be increased when it is combined with Lasmiditan.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Cobimetinib.
Tazemetostat Tazemetostat The metabolism of Tazemetostat can be decreased when combined with Cobimetinib.
Bempedoic Acid Bempedoic Acid The excretion of Cobimetinib can be decreased when combined with Bempedoic acid.
Cenobamate Cenobamate The serum concentration of Cobimetinib can be decreased when it is combined with Cenobamate.
Selumetinib Selumetinib The serum concentration of Selumetinib can be increased when it is combined with Cobimetinib.
Rimegepant Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Cobimetinib.
Tucatinib Tucatinib Cobimetinib may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Remdesivir Injection Remdesivir Injection The serum concentration of Cobimetinib can be increased when it is combined with Remdesivir.
Ripretinib Ripretinib The serum concentration of Cobimetinib can be increased when it is combined with Ripretinib.
Capmatinib Capmatinib The serum concentration of Cobimetinib can be increased when it is combined with Capmatinib.
Lemborexant Lemborexant The serum concentration of Lemborexant can be increased when it is combined with Cobimetinib.
Fostemsavir Fostemsavir The serum concentration of Cobimetinib can be increased when it is combined with Fostemsavir.
Octreotide Octreotide The serum concentration of Cobimetinib can be increased when it is combined with Octreotide.
Belantamab Mafodotin-blmf Injection Belantamab Mafodotin-blmf Injection The serum concentration of Belantamab mafodotin can be increased when it is combined with Cobimetinib.
Pralsetinib Pralsetinib The serum concentration of Cobimetinib can be increased when it is combined with Pralsetinib.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Cobimetinib can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Cobimetinib can be decreased when combined with Drospirenone.
Vitamin E (Alpha-Tocopherol) Vitamin E (Alpha-Tocopherol) The metabolism of Cobimetinib can be increased when combined with Vitamin E.
Theophylline Theophylline The metabolism of Theophylline can be decreased when combined with Cobimetinib.
Indomethacin Indomethacin The excretion of Cobimetinib can be decreased when combined with Indomethacin.
Trazodone Trazodone The serum concentration of Cobimetinib can be decreased when it is combined with Trazodone.
Phenobarbital Phenobarbital The metabolism of Cobimetinib can be increased when combined with Phenobarbital.
Methotrexate Injection Methotrexate Injection The metabolism of Methotrexate can be decreased when combined with Cobimetinib.
Primidone Primidone The metabolism of Cobimetinib can be increased when combined with Primidone.
Chlorpromazine Chlorpromazine The metabolism of Cobimetinib can be increased when combined with Chlorpromazine.
Diazepam Diazepam The metabolism of Cobimetinib can be decreased when combined with Diazepam.
Lorazepam Lorazepam The metabolism of Cobimetinib can be decreased when combined with Lorazepam.
Bromocriptine Bromocriptine The metabolism of Cobimetinib can be decreased when combined with Bromocriptine.
Tranylcypromine Tranylcypromine The metabolism of Cobimetinib can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine The metabolism of Cobimetinib can be decreased when combined with Phenelzine.
Tetracycline Tetracycline The metabolism of Cobimetinib can be decreased when combined with Tetracycline.
Prochlorperazine Prochlorperazine The metabolism of Cobimetinib can be decreased when combined with Prochlorperazine.
Methadone Methadone The metabolism of Cobimetinib can be increased when combined with Methadone.
Oxybutynin Oxybutynin The metabolism of Cobimetinib can be decreased when combined with Oxybutynin.
Orphenadrine Orphenadrine The metabolism of Cobimetinib can be decreased when combined with Orphenadrine.
Phentermine Phentermine The metabolism of Cobimetinib can be decreased when combined with Phentermine.
Sulfasalazine Sulfasalazine The excretion of Cobimetinib can be decreased when combined with Sulfasalazine.
Hydrocortisone Hydrocortisone The metabolism of Cobimetinib can be increased when combined with Hydrocortisone.
Doxorubicin Doxorubicin The metabolism of Cobimetinib can be decreased when combined with Doxorubicin.
Dactinomycin Dactinomycin The serum concentration of Cobimetinib can be increased when it is combined with Dactinomycin.
Carbamazepine Carbamazepine The metabolism of Carbamazepine can be increased when combined with Cobimetinib.
Clonidine Clonidine The metabolism of Clonidine can be decreased when combined with Cobimetinib.
Hydralazine Hydralazine The metabolism of Cobimetinib can be decreased when combined with Hydralazine.
Cimetidine Cimetidine The metabolism of Cobimetinib can be decreased when combined with Cimetidine.
Warfarin Warfarin The metabolism of Warfarin can be increased when combined with Cobimetinib.
Loperamide Loperamide The metabolism of Cobimetinib can be decreased when combined with Loperamide.
Daunorubicin Daunorubicin The metabolism of Cobimetinib can be decreased when combined with Daunorubicin.
Griseofulvin Griseofulvin The metabolism of Cobimetinib can be increased when combined with Griseofulvin.
Digoxin Digoxin The serum concentration of Cobimetinib can be increased when it is combined with Digoxin.
Loxapine Loxapine The serum concentration of Cobimetinib can be increased when it is combined with Loxapine.
Quinine Quinine The serum concentration of Cobimetinib can be increased when it is combined with Quinine.
Calcitriol Calcitriol The metabolism of Cobimetinib can be increased when combined with Calcitriol.
Sulfinpyrazone Sulfinpyrazone The metabolism of Cobimetinib can be increased when combined with Sulfinpyrazone.
Secobarbital Secobarbital The metabolism of Cobimetinib can be increased when combined with Secobarbital.
Desipramine Desipramine The metabolism of Cobimetinib can be decreased when combined with Desipramine.
Imipramine Imipramine The serum concentration of Imipramine can be increased when it is combined with Cobimetinib.
Probenecid Probenecid The metabolism of Cobimetinib can be increased when combined with Probenecid.
Quinidine Quinidine The serum concentration of Quinidine can be increased when it is combined with Cobimetinib.
Isoniazid Isoniazid The metabolism of Cobimetinib can be decreased when combined with Isoniazid.
Rifampin Rifampin The metabolism of Rifampicin can be increased when combined with Cobimetinib.
Valproic Acid Valproic Acid The metabolism of Cobimetinib can be decreased when combined with Valproic acid.
Tamoxifen Tamoxifen The serum concentration of Cobimetinib can be increased when it is combined with Tamoxifen.
Levothyroxine Levothyroxine The serum concentration of Levothyroxine can be decreased when it is combined with Cobimetinib.
Liothyronine Liothyronine The excretion of Liothyronine can be decreased when combined with Cobimetinib.
Methimazole Methimazole The metabolism of Cobimetinib can be decreased when combined with Methimazole.
Niacin Niacin The metabolism of Cobimetinib can be decreased when combined with Niacin.
Danazol Danazol The metabolism of Cobimetinib can be decreased when combined with Danazol.
Nortriptyline Nortriptyline The metabolism of Nortriptyline can be decreased when combined with Cobimetinib.
Amphotericin B Injection Amphotericin B Injection The metabolism of Cobimetinib can be decreased when combined with Amphotericin B.
Clomiphene Clomiphene The serum concentration of Cobimetinib can be increased when it is combined with Clomifene.
Colchicine Colchicine The metabolism of Cobimetinib can be increased when combined with Colchicine.
Cephalexin Cephalexin The metabolism of Cobimetinib can be decreased when combined with Cephalexin.
Acetazolamide Acetazolamide The metabolism of Cobimetinib can be decreased when combined with Acetazolamide.
Nystatin Nystatin The excretion of Cobimetinib can be decreased when combined with Nystatin.
Ketoconazole Ketoconazole The serum concentration of Cobimetinib can be increased when it is combined with Ketoconazole.
Thiotepa Injection Thiotepa Injection The metabolism of Thiotepa can be decreased when combined with Cobimetinib.
Vincristine Injection Vincristine Injection The metabolism of Cobimetinib can be decreased when combined with Vincristine.
Dipyridamole Dipyridamole The excretion of Cobimetinib can be decreased when combined with Dipyridamole.
Vinblastine Vinblastine The metabolism of Cobimetinib can be increased when combined with Vinblastine.
Metoprolol Metoprolol The metabolism of Cobimetinib can be decreased when combined with Metoprolol.
Diltiazem Diltiazem The metabolism of Cobimetinib can be decreased when combined with Diltiazem.
Nifedipine Nifedipine The metabolism of Cobimetinib can be increased when combined with Nifedipine.
Verapamil Verapamil The metabolism of Cobimetinib can be decreased when combined with Verapamil.
Etoposide Etoposide The metabolism of Cobimetinib can be increased when combined with Etoposide.
Glyburide Glyburide The metabolism of Cobimetinib can be decreased when combined with Glyburide.
Dicloxacillin Dicloxacillin The metabolism of Cobimetinib can be increased when combined with Dicloxacillin.
Nafcillin Injection Nafcillin Injection The metabolism of Cobimetinib can be increased when combined with Nafcillin.
Gemfibrozil Gemfibrozil The excretion of Cobimetinib can be decreased when combined with Gemfibrozil.
Pimozide Pimozide The metabolism of Pimozide can be decreased when combined with Cobimetinib.
Amiodarone Amiodarone The serum concentration of Amiodarone can be increased when it is combined with Cobimetinib.
Lovastatin Lovastatin The metabolism of Lovastatin can be decreased when combined with Cobimetinib.
Ciprofloxacin Ciprofloxacin The metabolism of Cobimetinib can be decreased when combined with Ciprofloxacin.
Diclofenac Diclofenac The excretion of Cobimetinib can be decreased when combined with Diclofenac.
Clozapine Clozapine The metabolism of Cobimetinib can be decreased when combined with Clozapine.
Clarithromycin Clarithromycin The serum concentration of Cobimetinib can be increased when it is combined with Clarithromycin.
Felodipine Felodipine The metabolism of Cobimetinib can be decreased when combined with Felodipine.
Pravastatin Pravastatin The serum concentration of Cobimetinib can be increased when it is combined with Pravastatin.
Simvastatin Simvastatin The serum concentration of Cobimetinib can be increased when it is combined with Simvastatin.
Epoetin Alfa, Injection Epoetin Alfa, Injection The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Cobimetinib.
Teniposide Injection Teniposide Injection The metabolism of Cobimetinib can be decreased when combined with Teniposide.
Itraconazole Itraconazole The serum concentration of Cobimetinib can be increased when it is combined with Itraconazole.
Rifabutin Rifabutin The metabolism of Cobimetinib can be increased when combined with Rifabutin.
Bisoprolol Bisoprolol The serum concentration of Cobimetinib can be increased when it is combined with Bisoprolol.
Doxazosin Doxazosin The metabolism of Cobimetinib can be decreased when combined with Doxazosin.
Isradipine Isradipine The metabolism of Cobimetinib can be decreased when combined with Isradipine.
Omeprazole Omeprazole The metabolism of Cobimetinib can be increased when combined with Omeprazole.
Cisapride Cisapride The metabolism of Cisapride can be decreased when combined with Cobimetinib.
Fluvastatin Fluvastatin The metabolism of Cobimetinib can be decreased when combined with Fluvastatin.
Famciclovir Famciclovir The metabolism of Cobimetinib can be decreased when combined with Famciclovir.
Fluvoxamine Fluvoxamine The metabolism of Cobimetinib can be decreased when combined with Fluvoxamine.
Nefazodone Nefazodone The metabolism of Cobimetinib can be decreased when combined with Nefazodone.
Losartan Losartan The metabolism of Cobimetinib can be decreased when combined with Losartan.
Vinorelbine Injection Vinorelbine Injection The metabolism of Vinorelbine can be decreased when combined with Cobimetinib.
Lansoprazole Lansoprazole The metabolism of Cobimetinib can be increased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The metabolism of Cobimetinib can be increased when combined with Ifosfamide.
Nicardipine Nicardipine The metabolism of Cobimetinib can be decreased when combined with Nicardipine.
Ticlopidine Ticlopidine The metabolism of Cobimetinib can be decreased when combined with Ticlopidine.
Saquinavir Saquinavir The serum concentration of Saquinavir can be increased when it is combined with Cobimetinib.
Gemcitabine Injection Gemcitabine Injection The serum concentration of Cobimetinib can be increased when it is combined with Gemcitabine.
Indinavir Indinavir The excretion of Cobimetinib can be decreased when combined with Indinavir.
Ritonavir Ritonavir The serum concentration of Cobimetinib can be increased when it is combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Cobimetinib can be decreased when combined with Docetaxel.
Clomipramine Clomipramine The metabolism of Clomipramine can be decreased when combined with Cobimetinib.
Zafirlukast Zafirlukast The metabolism of Cobimetinib can be decreased when combined with Zafirlukast.
Mirtazapine Mirtazapine The metabolism of Cobimetinib can be decreased when combined with Mirtazapine.
Topiramate Topiramate The metabolism of Cobimetinib can be increased when combined with Topiramate.
Valsartan Valsartan The excretion of Cobimetinib can be decreased when combined with Valsartan.
Nelfinavir Nelfinavir The excretion of Cobimetinib can be decreased when combined with Nelfinavir.
Fexofenadine Fexofenadine The serum concentration of Cobimetinib can be increased when it is combined with Fexofenadine.
Azithromycin Azithromycin The metabolism of Cobimetinib can be decreased when combined with Azithromycin.
Carvedilol Carvedilol The serum concentration of Cobimetinib can be increased when it is combined with Carvedilol.
Bicalutamide Bicalutamide The metabolism of Cobimetinib can be decreased when combined with Bicalutamide.
Propafenone Propafenone The serum concentration of Cobimetinib can be increased when it is combined with Propafenone.
Raloxifene Raloxifene The metabolism of Cobimetinib can be decreased when combined with Raloxifene.
Irbesartan Irbesartan The metabolism of Cobimetinib can be decreased when combined with Irbesartan.
Paroxetine Paroxetine The metabolism of Cobimetinib can be decreased when combined with Paroxetine.
Citalopram Citalopram The metabolism of Cobimetinib can be decreased when combined with Citalopram.
Efavirenz Efavirenz The metabolism of Cobimetinib can be increased when combined with Efavirenz.
Sildenafil Sildenafil The serum concentration of Cobimetinib can be increased when it is combined with Sildenafil.
Rosiglitazone Rosiglitazone The excretion of Cobimetinib can be decreased when combined with Rosiglitazone.
Rabeprazole Rabeprazole The metabolism of Cobimetinib can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Cobimetinib can be increased when combined with Terbinafine.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists