Selpercatinib

Generic name: Pronounced as (sel" per ka' ti nib)
Brand names
  • Retevmo®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 04/15/2021

Selpercatinib is used to treat a certain type of non-small cell lung cancer (NSCLC) in adults that has spread to other parts of the body in adults. It is also used to treat a certain type of thyroid cancer in adults and children 12 years of age and older that has spread to other parts of the body. Selpercatinib is also used to treat another type of thyroid cancer that has spread to other parts of the body in adults and children 12 years of age and older who have been treated unsuccessfully with radioactive iodine. Selpercatinib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps slow or stop the spread of cancer cells.

Selpercatinib comes as a capsule to take by mouth. It is usually taken twice daily (every 12 hours) with or without food. Take selpercatinib at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take selpercatinib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the capsules whole; do not open, chew, or crush them.

If you vomit after taking selpercatinib, do not take another dose. Continue your regular dosing schedule.

Your doctor may decrease your dose, or interrupt or discontinue your treatment. This depends on how well the medication works for you and the side effects you experience. Talk to your doctor about how you are feeling during your treatment. Continue to take selpercatinib even if you feel well. Do not stop taking selpercatinib without talking to your doctor.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking selpercatinib,

  • tell your doctor and pharmacist if you are allergic to selpercatinib, any other medications, or any of the ingredients in selpercatinib capsules. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antifungals such as fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole, and voriconazole (Vfend); aprepitant (Emend); carbamazepine (Carbatrol, Tegretol, Equetro, others); clarithromycin (Biaxin, in Prevpac); diltiazem (Cardizem, Cartia, Tiazac, others); erythromycin (E.E.S., E-Mycin, Erythrocin); certain medications for human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) including efavirenz (Sustiva), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, in Kaletra), and saquinavir (Invirase); nefazodone; phenobarbital; phenytoin (Dilantin, Phenytek); pioglitazone (Actos); quinidine (in Nuedexta); repaglinide (Prandin); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane, in Rifamate, in Rifater); and verapamil (Calan, Verelan, others). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with selpercatinib, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

  • if you are taking an H2 blocker medication for indigestion, heartburn, or ulcers such as cimetidine (Tagamet), famotidine (Pepcid), nizatidine (Axid), or ranitidine (Zantac), take selpercatinib at least 2 hours before or 10 hours after taking one of these medications.

  • if you are taking an antacid that contains aluminum, magnesium, calcium, or simethicone; or buffered medications such as buffered aspirin, take selpercatinib at least 2 hours before or at least 2 hours after you take one of these medications.

  • if you are taking a proton-pump inhibitor such as esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), and rabeprazole (AcipHex), take each dose of selpercatinib along with food.

  • tell your doctor what herbal products you are taking, especially St. John's wort.

  • tell your doctor if you have or have ever had a slow, fast, or irregular heartbeat; a prolonged QT interval (a rare heart problem that may cause irregular heartbeat, fainting, or sudden death); high blood pressure; bleeding problems; or kidney or liver disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or if you plan on fathering a child. You should not become pregnant while you are taking selpercatinib. If you are female, you will need to take a pregnancy test before you start treatment and use birth control to prevent pregnancy during your treatment with selpercatinib and for 1 week after your final dose. If you are male, you and your female partner should use birth control during your treatment with selpercatinib and for 1 week after your final dose. If you or your partner become pregnant while taking selpercatinib, call your doctor immediately. Selpercatinib can cause fetal harm.

  • tell your doctor if you are breastfeeding. You should not breastfeed while you are taking selpercatinib and for 1 week after your final dose.

  • you should know that this medication may decrease fertility in men and women. Talk to your doctor about the risks of taking selpercatinib.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking selpercatinib. Your doctor may tell you not to take selpercatinib 7 days before your surgery or procedure and will tell you when you should start taking the medication again.

Do not eat grapefruit or drink grapefruit juice while taking this medication.

Take the missed dose as soon as you remember it. However, if it is within 6 hours of your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Selpercatinib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • dry mouth

    • diarrhea

    • constipation

    • nausea

    • vomiting

    • stomach pain

    • headache

    • tiredness

    • cough

    • shortness of breath

    • swelling of your arms, legs, hands, and feet

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

    • pain in the right upper part of the stomach; unusual bruising or bleeding; dark urine; or yellowing of the skin and eye

    • heart palpitations

    • dizziness or lightheadedness

    • fainting

    • coughing up or vomiting blood or material that looks like coffee grounds; unusual bleeding or bruising, pink; red, or dark brown urine; or red or tarry black bowel movements

    • nausea; vomiting; shortness of breath; muscle cramps; weakness; seizures; or swelling of arms and legs

    • fever, rash, or joint or muscle pain

  • Selpercatinib may cause the bones to stop growing too soon in teenagers who are still growing. Talk to your child's doctor about the risks of giving this medication to your child.

  • Selpercatinib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor and the laboratory. Your doctor will check your blood pressure regularly and order certain lab tests before and during your treatment to check your body's response to selpercatinib.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Repaglinide Repaglinide The serum concentration of Repaglinide can be increased when it is combined with Selpercatinib.
Montelukast Montelukast The serum concentration of Montelukast can be increased when it is combined with Selpercatinib.
Atorvastatin Atorvastatin The serum concentration of Atorvastatin can be decreased when it is combined with Selpercatinib.
Calcium Carbonate Calcium Carbonate The serum concentration of Selpercatinib can be decreased when it is combined with Calcium carbonate.
Candesartan Candesartan Selpercatinib may decrease the antihypertensive activities of Candesartan.
Guanfacine Guanfacine Selpercatinib may decrease the antihypertensive activities of Guanfacine.
Magnesium Hydroxide Magnesium Hydroxide The serum concentration of Selpercatinib can be decreased when it is combined with Magnesium hydroxide.
Magnesium Oxide Magnesium Oxide The serum concentration of Selpercatinib can be decreased when it is combined with Magnesium oxide.
Methylergonovine Methylergonovine The risk or severity of hypertension can be increased when Methylergometrine is combined with Selpercatinib.
Naratriptan Naratriptan The risk or severity of hypertension can be increased when Naratriptan is combined with Selpercatinib.
Olsalazine Olsalazine The risk or severity of hypertension can be increased when Olsalazine is combined with Selpercatinib.
Paregoric Paregoric The serum concentration of Morphine can be increased when it is combined with Selpercatinib.
Penbutolol Penbutolol Selpercatinib may decrease the antihypertensive activities of Acebutolol.
Ranitidine Ranitidine The serum concentration of Selpercatinib can be decreased when it is combined with Ranitidine.
Reserpine Reserpine The serum concentration of Reserpine can be decreased when it is combined with Selpercatinib.
Rizatriptan Rizatriptan The risk or severity of hypertension can be increased when Rizatriptan is combined with Selpercatinib.
Sumatriptan Sumatriptan The risk or severity of hypertension can be increased when Sumatriptan is combined with Selpercatinib.
Zolmitriptan Zolmitriptan The risk or severity of hypertension can be increased when Zolmitriptan is combined with Selpercatinib.
Famotidine Injection Famotidine Injection The serum concentration of Selpercatinib can be decreased when it is combined with Famotidine.
Levofloxacin Injection Levofloxacin Injection The excretion of Levofloxacin can be decreased when combined with Selpercatinib.
Meperidine Injection Meperidine Injection The serum concentration of Selpercatinib can be decreased when it is combined with Meperidine.
Methylprednisolone Injection Methylprednisolone Injection The serum concentration of Selpercatinib can be decreased when it is combined with Methylprednisolone.
Morphine Injection Morphine Injection The serum concentration of Morphine can be increased when it is combined with Selpercatinib.
Zidovudine Injection Zidovudine Injection The serum concentration of Zidovudine can be increased when it is combined with Selpercatinib.
Altretamine Altretamine The risk or severity of hypertension can be increased when Amphetamine is combined with Selpercatinib.
Cyclosporine Cyclosporine The risk or severity of hypertension can be increased when Cyclosporine is combined with Selpercatinib.
Torsemide Torsemide The serum concentration of Torasemide can be increased when it is combined with Selpercatinib.
Olanzapine Olanzapine The serum concentration of Selpercatinib can be decreased when it is combined with Olanzapine.
Eprosartan Eprosartan Selpercatinib may decrease the antihypertensive activities of Eprosartan.
Hydroxychloroquine Hydroxychloroquine The serum concentration of Hydroxychloroquine can be increased when it is combined with Selpercatinib.
Meloxicam Meloxicam The risk or severity of hypertension can be increased when Meloxicam is combined with Selpercatinib.
Orlistat Orlistat The serum concentration of Selpercatinib can be decreased when it is combined with Orlistat.
Oxcarbazepine Oxcarbazepine The serum concentration of Selpercatinib can be decreased when it is combined with Oxcarbazepine.
Pantoprazole Pantoprazole The serum concentration of Selpercatinib can be decreased when it is combined with Pantoprazole.
Telmisartan Telmisartan Selpercatinib may decrease the antihypertensive activities of Telmisartan.
Temozolomide Temozolomide The serum concentration of Selpercatinib can be decreased when it is combined with Temozolomide.
Linezolid Linezolid The risk or severity of hypertension can be increased when Linezolid is combined with Selpercatinib.
Trimipramine Trimipramine The risk or severity of hypertension can be increased when Trimipramine is combined with Selpercatinib.
Modafinil Modafinil The serum concentration of Selpercatinib can be increased when it is combined with Modafinil.
Perindopril Perindopril Selpercatinib may decrease the antihypertensive activities of Perindopril.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate The risk or severity of hypertension can be increased when Choline magnesium trisalicylate is combined with Selpercatinib.
Dutasteride Dutasteride The risk or severity of hypertension can be increased when Dutasteride is combined with Selpercatinib.
Epinephrine Injection Epinephrine Injection The risk or severity of hypertension can be increased when Epinephrine is combined with Selpercatinib.
Eplerenone Eplerenone Selpercatinib may decrease the antihypertensive activities of Eplerenone.
Olmesartan Olmesartan Selpercatinib may decrease the antihypertensive activities of Olmesartan.
Aripiprazole Aripiprazole The risk or severity of hypertension can be increased when Aripiprazole is combined with Selpercatinib.
Atomoxetine Atomoxetine The risk or severity of hypertension can be increased when Atomoxetine is combined with Selpercatinib.
Dexmethylphenidate Dexmethylphenidate The risk or severity of hypertension can be increased when Dexmethylphenidate is combined with Selpercatinib.
Teriparatide Injection Teriparatide Injection The therapeutic efficacy of Teriparatide can be decreased when used in combination with Selpercatinib.
Atazanavir Atazanavir The serum concentration of Selpercatinib can be increased when it is combined with Atazanavir.
Almotriptan Almotriptan The serum concentration of Selpercatinib can be increased when it is combined with Almotriptan.
Eletriptan Eletriptan The serum concentration of Selpercatinib can be decreased when it is combined with Eletriptan.
Emtricitabine Emtricitabine The excretion of Emtricitabine can be decreased when combined with Selpercatinib.
Tadalafil Tadalafil Selpercatinib may decrease the antihypertensive activities of Tadalafil.
Frovatriptan Frovatriptan The risk or severity of hypertension can be increased when Frovatriptan is combined with Selpercatinib.
Progesterone Progesterone The serum concentration of Selpercatinib can be increased when it is combined with Progesterone.
Apomorphine Injection Apomorphine Injection The serum concentration of Apomorphine can be increased when it is combined with Selpercatinib.
Darbepoetin Alfa Injection Darbepoetin Alfa Injection The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Selpercatinib.
Protriptyline Protriptyline The risk or severity of hypertension can be increased when Protriptyline is combined with Selpercatinib.
Rifaximin Rifaximin The serum concentration of Selpercatinib can be decreased when it is combined with Rifaximin.
Bosentan Bosentan The serum concentration of Bosentan can be decreased when it is combined with Selpercatinib.
Erlotinib Erlotinib The serum concentration of Erlotinib can be increased when it is combined with Selpercatinib.
Eszopiclone Eszopiclone The serum concentration of Eszopiclone can be increased when it is combined with Selpercatinib.
Ganciclovir Ganciclovir The excretion of Ganciclovir can be decreased when combined with Selpercatinib.
Solifenacin Solifenacin The risk or severity of hypertension can be increased when Solifenacin is combined with Selpercatinib.
Dextroamphetamine Dextroamphetamine The risk or severity of hypertension can be increased when Amphetamine is combined with Selpercatinib.
Isocarboxazid Isocarboxazid The risk or severity of hypertension can be increased when Isocarboxazid is combined with Selpercatinib.
Fentanyl Fentanyl The risk or severity of hypertension can be increased when Fentanyl is combined with Selpercatinib.
Deferasirox Deferasirox The serum concentration of Selpercatinib can be decreased when it is combined with Deferasirox.
Phenylephrine Phenylephrine The risk or severity of hypertension can be increased when Phenylephrine is combined with Selpercatinib.
Felbamate Felbamate The serum concentration of Selpercatinib can be decreased when it is combined with Felbamate.
Ranolazine Ranolazine The serum concentration of Selpercatinib can be increased when it is combined with Ranolazine.
Rasagiline Rasagiline The risk or severity of hypertension can be increased when Rasagiline is combined with Selpercatinib.
Imatinib Imatinib The serum concentration of Imatinib can be increased when it is combined with Selpercatinib.
Sitagliptin Sitagliptin The serum concentration of Sitagliptin can be increased when it is combined with Selpercatinib.
Albuterol Albuterol The risk or severity of hypertension can be increased when Salbutamol is combined with Selpercatinib.
Paliperidone Paliperidone The risk or severity of hypertension can be increased when Paliperidone is combined with Selpercatinib.
Aliskiren Aliskiren Selpercatinib may decrease the antihypertensive activities of Aliskiren.
Lisdexamfetamine Lisdexamfetamine The risk or severity of hypertension can be increased when Lisdexamfetamine is combined with Selpercatinib.
Sorafenib Sorafenib The serum concentration of Sorafenib can be increased when it is combined with Selpercatinib.
Lapatinib Lapatinib The serum concentration of Lapatinib can be increased when it is combined with Selpercatinib.
Armodafinil Armodafinil The serum concentration of Selpercatinib can be decreased when it is combined with Armodafinil.
Bexarotene Bexarotene The serum concentration of Selpercatinib can be decreased when it is combined with Bexarotene.
Budesonide Budesonide The serum concentration of Selpercatinib can be decreased when it is combined with Budesonide.
Desmopressin Desmopressin The risk or severity of hypertension can be increased when Desmopressin is combined with Selpercatinib.
Etravirine Etravirine The serum concentration of Selpercatinib can be decreased when it is combined with Etravirine.
Nebivolol Nebivolol Selpercatinib may decrease the antihypertensive activities of Nebivolol.
Tretinoin Tretinoin The serum concentration of Tretinoin can be increased when it is combined with Selpercatinib.
Flecainide Flecainide The excretion of Flecainide can be decreased when combined with Selpercatinib.
Mitotane Mitotane The serum concentration of Selpercatinib can be decreased when it is combined with Mitotane.
Rufinamide Rufinamide The serum concentration of Selpercatinib can be decreased when it is combined with Rufinamide.
Eltrombopag Eltrombopag The serum concentration of Eltrombopag can be increased when it is combined with Selpercatinib.
Dexlansoprazole Dexlansoprazole The serum concentration of Selpercatinib can be decreased when it is combined with Dexlansoprazole.
Betaxolol Betaxolol Selpercatinib may decrease the antihypertensive activities of Betaxolol.
Iloperidone Iloperidone The risk or severity of hypertension can be increased when Iloperidone is combined with Selpercatinib.
Dronedarone Dronedarone The risk or severity of hypertension can be increased when Dronedarone is combined with Selpercatinib.
Topotecan Topotecan The serum concentration of Topotecan can be decreased when it is combined with Selpercatinib.
Pazopanib Pazopanib The serum concentration of Pazopanib can be increased when it is combined with Selpercatinib.
Asenapine Asenapine The serum concentration of Selpercatinib can be decreased when it is combined with Asenapine.
Pitavastatin Pitavastatin The serum concentration of Pitavastatin can be increased when it is combined with Selpercatinib.
Tocilizumab Injection Tocilizumab Injection The serum concentration of Selpercatinib can be decreased when it is combined with Tocilizumab.
Cabazitaxel Injection Cabazitaxel Injection The serum concentration of Cabazitaxel can be increased when it is combined with Selpercatinib.
Lurasidone Lurasidone The risk or severity of hypertension can be increased when Lurasidone is combined with Selpercatinib.
Acetaminophen Injection Acetaminophen Injection The serum concentration of Acetaminophen can be decreased when it is combined with Selpercatinib.
Vilazodone Vilazodone The risk or severity of hypertension can be increased when Vilazodone is combined with Selpercatinib.
Terbutaline Injection Terbutaline Injection The risk or severity of hypertension can be increased when Terbutaline is combined with Selpercatinib.
Telaprevir Telaprevir The serum concentration of Selpercatinib can be increased when it is combined with Glecaprevir.
Potassium Iodide Potassium Iodide The therapeutic efficacy of Potassium Iodide can be decreased when used in combination with Selpercatinib.
Cyclophosphamide Injection Cyclophosphamide Injection The serum concentration of Cyclophosphamide can be decreased when it is combined with Selpercatinib.
Clobazam Clobazam The serum concentration of Selpercatinib can be decreased when it is combined with Clobazam.
Vemurafenib Vemurafenib The serum concentration of Selpercatinib can be decreased when it is combined with Vemurafenib.
Crizotinib Crizotinib The serum concentration of Selpercatinib can be increased when it is combined with Crizotinib.
Cabergoline Cabergoline The risk or severity of hypertension can be increased when Cabergoline is combined with Selpercatinib.
Ambrisentan Ambrisentan Selpercatinib may decrease the antihypertensive activities of Ambrisentan.
Enzalutamide Enzalutamide The serum concentration of Enzalutamide can be decreased when it is combined with Selpercatinib.
Mirabegron Mirabegron The risk or severity of hypertension can be increased when Mirabegron is combined with Selpercatinib.
Corticotropin, Repository Injection Corticotropin, Repository Injection The serum concentration of Selpercatinib can be decreased when it is combined with Corticotropin.
Ponatinib Ponatinib The serum concentration of Ponatinib can be increased when it is combined with Selpercatinib.
Apixaban Apixaban The serum concentration of Apixaban can be increased when it is combined with Selpercatinib.
Dabrafenib Dabrafenib The serum concentration of Dabrafenib can be decreased when it is combined with Selpercatinib.
Trametinib Trametinib The serum concentration of Selpercatinib can be decreased when it is combined with Trametinib.
Levomilnacipran Levomilnacipran The serum concentration of Levomilnacipran can be increased when it is combined with Selpercatinib.
Vortioxetine Vortioxetine The serum concentration of Selpercatinib can be increased when it is combined with Vortioxetine.
Perampanel Perampanel The serum concentration of Selpercatinib can be decreased when it is combined with Perampanel.
Ketorolac Injection Ketorolac Injection The serum concentration of Selpercatinib can be increased when it is combined with Ketorolac.
Droxidopa Droxidopa The risk or severity of hypertension can be increased when Droxidopa is combined with Selpercatinib.
Siltuximab Injection Siltuximab Injection The serum concentration of Selpercatinib can be decreased when it is combined with Siltuximab.
Eslicarbazepine Eslicarbazepine The serum concentration of Selpercatinib can be decreased when it is combined with Eslicarbazepine.
Idelalisib Idelalisib The serum concentration of Selpercatinib can be increased when it is combined with Idelalisib.
Testosterone Injection Testosterone Injection The serum concentration of Selpercatinib can be decreased when it is combined with Testosterone.
Oritavancin Injection Oritavancin Injection The serum concentration of Selpercatinib can be decreased when it is combined with Oritavancin.
Suvorexant Suvorexant The serum concentration of Selpercatinib can be increased when it is combined with Suvorexant.
Methamphetamine Methamphetamine The risk or severity of hypertension can be increased when Metamfetamine is combined with Selpercatinib.
Riociguat Riociguat The serum concentration of Riociguat can be increased when it is combined with Selpercatinib.
Risperidone Injection Risperidone Injection The risk or severity of hypertension can be increased when Risperidone is combined with Selpercatinib.
Lenvatinib Lenvatinib The serum concentration of Selpercatinib can be decreased when it is combined with Lenvatinib.
Haloperidol Injection Haloperidol Injection The risk or severity of QTc prolongation can be increased when Selpercatinib is combined with Haloperidol.
Isavuconazonium Injection Isavuconazonium Injection The serum concentration of Selpercatinib can be decreased when it is combined with Isavuconazonium.
Macitentan Macitentan Selpercatinib may decrease the antihypertensive activities of Macitentan.
Flibanserin Flibanserin The risk or severity of hypertension can be increased when Flibanserin is combined with Selpercatinib.
Prednisolone Prednisolone The serum concentration of Selpercatinib can be decreased when it is combined with Prednisolone.
Brexpiprazole Brexpiprazole The risk or severity of hypertension can be increased when Brexpiprazole is combined with Selpercatinib.
Ziprasidone Injection Ziprasidone Injection The risk or severity of QTc prolongation can be increased when Ziprasidone is combined with Selpercatinib.
Cariprazine Cariprazine The risk or severity of hypertension can be increased when Cariprazine is combined with Selpercatinib.
Osimertinib Osimertinib The serum concentration of Selpercatinib can be decreased when it is combined with Osimertinib.
Rifapentine Rifapentine The serum concentration of Selpercatinib can be decreased when it is combined with Rifapentine.
Lesinurad Lesinurad The serum concentration of Selpercatinib can be decreased when it is combined with Lesinurad.
Dexamethasone Injection Dexamethasone Injection The serum concentration of Selpercatinib can be decreased when it is combined with Dexamethasone.
Cobicistat Cobicistat The serum concentration of Selpercatinib can be increased when it is combined with Cobicistat.
Midodrine Midodrine The risk or severity of hypertension can be increased when Midodrine is combined with Selpercatinib.
Selexipag Selexipag The serum concentration of Selexipag can be increased when it is combined with Selpercatinib.
Furosemide Injection Furosemide Injection Selpercatinib may decrease the antihypertensive activities of Furosemide.
Parathyroid Hormone Injection Parathyroid Hormone Injection The therapeutic efficacy of Parathyroid hormone can be decreased when used in combination with Selpercatinib.
Brigatinib Brigatinib The serum concentration of Brigatinib can be decreased when it is combined with Selpercatinib.
Doxepin (Insomnia) Doxepin (Insomnia) The serum concentration of Selpercatinib can be decreased when it is combined with Doxepin.
Safinamide Safinamide The risk or severity of hypertension can be increased when Safinamide is combined with Selpercatinib.
Sarilumab Injection Sarilumab Injection The serum concentration of Selpercatinib can be decreased when it is combined with Sarilumab.
Midostaurin Midostaurin The serum concentration of Selpercatinib can be decreased when it is combined with Midostaurin.
Abaloparatide Injection Abaloparatide Injection The therapeutic efficacy of Abaloparatide can be decreased when used in combination with Selpercatinib.
Enasidenib Enasidenib The serum concentration of Enasidenib can be decreased when it is combined with Selpercatinib.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The serum concentration of Selpercatinib can be decreased when it is combined with Fosaprepitant.
Delafloxacin Delafloxacin The serum concentration of Selpercatinib can be decreased when it is combined with Delafloxacin.
Abemaciclib Abemaciclib The excretion of Abemaciclib can be decreased when combined with Selpercatinib.
Acalabrutinib Acalabrutinib The serum concentration of Selpercatinib can be increased when it is combined with Acalabrutinib.
Buprenorphine Injection Buprenorphine Injection The serum concentration of Buprenorphine can be increased when it is combined with Selpercatinib.
Apalutamide Apalutamide The serum concentration of Apalutamide can be decreased when it is combined with Selpercatinib.
Lofexidine Lofexidine Selpercatinib may decrease the antihypertensive activities of Lofexidine.
Ivosidenib Ivosidenib The serum concentration of Selpercatinib can be decreased when it is combined with Ivosidenib.
Elagolix Elagolix The serum concentration of Elagolix can be increased when it is combined with Selpercatinib.
Cannabidiol Cannabidiol The risk or severity of hypertension can be increased when Cannabidiol is combined with Selpercatinib.
Glasdegib Glasdegib The serum concentration of Glasdegib can be increased when it is combined with Selpercatinib.
Lorlatinib Lorlatinib The serum concentration of Lorlatinib can be decreased when it is combined with Selpercatinib.
Methoxy Polyethylene Glycol-Epoetin Beta Injection Methoxy Polyethylene Glycol-Epoetin Beta Injection The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Selpercatinib.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The serum concentration of Paclitaxel can be decreased when it is combined with Selpercatinib.
Rifamycin Rifamycin The serum concentration of Selpercatinib can be decreased when it is combined with Rifamycin.
Siponimod Siponimod The risk or severity of hypertension can be increased when Siponimod is combined with Selpercatinib.
Acyclovir Ophthalmic Acyclovir Ophthalmic The excretion of Acyclovir can be decreased when combined with Selpercatinib.
Esomeprazole Injection Esomeprazole Injection The serum concentration of Selpercatinib can be decreased when it is combined with Esomeprazole.
Alpelisib Alpelisib The serum concentration of Selpercatinib can be decreased when it is combined with Alpelisib.
Solriamfetol Solriamfetol The risk or severity of hypertension can be increased when Solriamfetol is combined with Selpercatinib.
Entrectinib Entrectinib The risk or severity of QTc prolongation can be increased when Selpercatinib is combined with Entrectinib.
Pexidartinib Pexidartinib Selpercatinib may increase the hepatotoxic activities of Pexidartinib.
Istradefylline Istradefylline The serum concentration of Istradefylline can be increased when it is combined with Selpercatinib.
Pitolisant Pitolisant The serum concentration of Selpercatinib can be decreased when it is combined with Pitolisant.
Lefamulin Lefamulin Lefamulin may increase the QTc-prolonging activities of Selpercatinib.
Phenytoin Injection Phenytoin Injection The serum concentration of Phenytoin can be decreased when it is combined with Selpercatinib.
Fosphenytoin Injection Fosphenytoin Injection The serum concentration of Fosphenytoin can be decreased when it is combined with Selpercatinib.
Cenobamate Cenobamate The serum concentration of Selpercatinib can be decreased when it is combined with Cenobamate.
Ozanimod Ozanimod The serum concentration of Ozanimod can be increased when it is combined with Selpercatinib.
Selumetinib Selumetinib The serum concentration of Selumetinib can be increased when it is combined with Selpercatinib.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Selpercatinib.
Remdesivir Injection Remdesivir Injection The serum concentration of Selpercatinib can be increased when it is combined with Remdesivir.
Pralsetinib Pralsetinib The serum concentration of Selpercatinib can be increased when it is combined with Pralsetinib.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Selpercatinib can be decreased when it is combined with Satralizumab.
Naxitamab-gqgk Injection Naxitamab-gqgk Injection The risk or severity of hypertension can be increased when Selpercatinib is combined with Naxitamab.
Theophylline Theophylline The serum concentration of Theophylline can be increased when it is combined with Selpercatinib.
Fenoprofen Fenoprofen The risk or severity of hypertension can be increased when Fenoprofen is combined with Selpercatinib.
Indomethacin Indomethacin The risk or severity of hypertension can be increased when Indomethacin is combined with Selpercatinib.
Mefenamic Acid Mefenamic Acid The risk or severity of hypertension can be increased when Mefenamic acid is combined with Selpercatinib.
Naproxen Naproxen The serum concentration of Selpercatinib can be increased when it is combined with Naproxen.
Tolmetin Tolmetin The risk or severity of hypertension can be increased when Tolmetin is combined with Selpercatinib.
Sulindac Sulindac The risk or severity of hypertension can be increased when Sulindac is combined with Selpercatinib.
Trazodone Trazodone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Selpercatinib.
Sodium Bicarbonate Sodium Bicarbonate The serum concentration of Selpercatinib can be decreased when it is combined with Sodium bicarbonate.
Phenobarbital Phenobarbital The serum concentration of Selpercatinib can be decreased when it is combined with Phenobarbital.
Primidone Primidone The serum concentration of Selpercatinib can be decreased when it is combined with Primidone.
Diethylpropion Diethylpropion The risk or severity of hypertension can be increased when Diethylpropion is combined with Selpercatinib.
Chlorpromazine Chlorpromazine The risk or severity of hypertension can be increased when Chlorpromazine is combined with Selpercatinib.
Phenoxybenzamine Phenoxybenzamine Selpercatinib may decrease the antihypertensive activities of Phenoxybenzamine.
Bromocriptine Bromocriptine The risk or severity of hypertension can be increased when Bromocriptine is combined with Selpercatinib.
Metaproterenol Metaproterenol The risk or severity of hypertension can be increased when Orciprenaline is combined with Selpercatinib.
Tranylcypromine Tranylcypromine The risk or severity of hypertension can be increased when Tranylcypromine is combined with Selpercatinib.
Phenelzine Phenelzine The risk or severity of hypertension can be increased when Phenelzine is combined with Selpercatinib.
Ergoloid Mesylates Ergoloid Mesylates The risk or severity of hypertension can be increased when Ergoloid mesylate is combined with Selpercatinib.
Thioridazine Thioridazine The risk or severity of hypertension can be increased when Thioridazine is combined with Selpercatinib.
Trifluoperazine Trifluoperazine The risk or severity of hypertension can be increased when Trifluoperazine is combined with Selpercatinib.
Dapsone Dapsone The serum concentration of Dapsone can be increased when it is combined with Selpercatinib.
Sulfadiazine Sulfadiazine The serum concentration of Sulfadiazine can be increased when it is combined with Selpercatinib.
Methadone Methadone The serum concentration of Methadone can be increased when it is combined with Selpercatinib.
Ibuprofen Ibuprofen The serum concentration of Selpercatinib can be increased when it is combined with Ibuprofen.
Phentermine Phentermine The risk or severity of hypertension can be increased when Phentermine is combined with Selpercatinib.
Methylphenidate Methylphenidate The risk or severity of hypertension can be increased when Methylphenidate is combined with Selpercatinib.
Amoxapine Amoxapine The risk or severity of hypertension can be increased when Amoxapine is combined with Selpercatinib.
Sulfasalazine Sulfasalazine The risk or severity of hypertension can be increased when Sulfasalazine is combined with Selpercatinib.
Hydrocortisone Hydrocortisone The serum concentration of Selpercatinib can be decreased when it is combined with Hydrocortisone.
Pyridostigmine Pyridostigmine The serum concentration of Selpercatinib can be decreased when it is combined with Pyridostigmine.
Carbamazepine Carbamazepine The serum concentration of Selpercatinib can be decreased when it is combined with Carbamazepine.
Methyldopa Methyldopa Selpercatinib may decrease the antihypertensive activities of Methyldopa.
Clonidine Clonidine Selpercatinib may decrease the antihypertensive activities of Clonidine.
Prazosin Prazosin Selpercatinib may decrease the antihypertensive activities of Prazosin.
Hydralazine Hydralazine Selpercatinib may decrease the antihypertensive activities of Hydralazine.
Cimetidine Cimetidine The serum concentration of Cimetidine can be decreased when it is combined with Selpercatinib.
Loperamide Loperamide The serum concentration of Loperamide can be increased when it is combined with Selpercatinib.
Promethazine Promethazine The serum concentration of Selpercatinib can be decreased when it is combined with Promethazine.
Meclofenamate Meclofenamate The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Selpercatinib.
Daunorubicin Daunorubicin The serum concentration of Selpercatinib can be decreased when it is combined with Daunorubicin.
Griseofulvin Griseofulvin The serum concentration of Selpercatinib can be decreased when it is combined with Griseofulvin.
Chloroquine Chloroquine The serum concentration of Chloroquine can be increased when it is combined with Selpercatinib.
Quinine Quinine The serum concentration of Quinine can be decreased when it is combined with Selpercatinib.
Calcitriol Calcitriol The serum concentration of Selpercatinib can be decreased when it is combined with Calcitriol.
Sulfinpyrazone Sulfinpyrazone The serum concentration of Selpercatinib can be decreased when it is combined with Sulfinpyrazone.
Chlorothiazide Chlorothiazide Selpercatinib may decrease the antihypertensive activities of Chlorothiazide.
Chlorthalidone Chlorthalidone Selpercatinib may decrease the antihypertensive activities of Chlorthalidone.
Metolazone Metolazone Selpercatinib may decrease the antihypertensive activities of Metolazone.
Secobarbital Secobarbital The serum concentration of Selpercatinib can be decreased when it is combined with Secobarbital.
Desipramine Desipramine The risk or severity of hypertension can be increased when Desipramine is combined with Selpercatinib.
Amitriptyline Amitriptyline The serum concentration of Selpercatinib can be increased when it is combined with Amitriptyline.
Imipramine Imipramine The risk or severity of hypertension can be increased when Imipramine is combined with Selpercatinib.
Probenecid Probenecid The serum concentration of Selpercatinib can be decreased when it is combined with Probenecid.
Quinidine Quinidine The serum concentration of Selpercatinib can be increased when it is combined with Quinidine.
Procainamide Procainamide The excretion of Procainamide can be decreased when combined with Selpercatinib.
Rifampin Rifampin The serum concentration of Selpercatinib can be decreased when it is combined with Rifampicin.
Tamoxifen Tamoxifen The serum concentration of Selpercatinib can be decreased when it is combined with Tamoxifen.
Levothyroxine Levothyroxine The therapeutic efficacy of Levothyroxine can be decreased when used in combination with Selpercatinib.
Liothyronine Liothyronine The therapeutic efficacy of Liothyronine can be decreased when used in combination with Selpercatinib.
Methimazole Methimazole The therapeutic efficacy of Methimazole can be decreased when used in combination with Selpercatinib.
Propylthiouracil Propylthiouracil The therapeutic efficacy of Propylthiouracil can be decreased when used in combination with Selpercatinib.
Tolbutamide Tolbutamide The serum concentration of Tolbutamide can be increased when it is combined with Selpercatinib.
Hydrochlorothiazide Hydrochlorothiazide Selpercatinib may decrease the antihypertensive activities of Hydrochlorothiazide.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) Selpercatinib may decrease the antihypertensive activities of Propranolol.
Minoxidil Minoxidil Selpercatinib may decrease the antihypertensive activities of Minoxidil.
Pseudoephedrine Pseudoephedrine The risk or severity of hypertension can be increased when Pseudoephedrine is combined with Selpercatinib.
Nortriptyline Nortriptyline The risk or severity of hypertension can be increased when Nortriptyline is combined with Selpercatinib.
Nadolol Nadolol The excretion of Nadolol can be decreased when combined with Selpercatinib.
Fluorouracil Injection Fluorouracil Injection The serum concentration of Fluorouracil can be increased when it is combined with Selpercatinib.
Colchicine Colchicine The serum concentration of Selpercatinib can be decreased when it is combined with Colchicine.
Cephalexin Cephalexin The excretion of Cephalexin can be decreased when combined with Selpercatinib.
Calcitonin Salmon Injection Calcitonin Salmon Injection The therapeutic efficacy of Salmon calcitonin can be decreased when used in combination with Selpercatinib.
Ketoconazole Ketoconazole The serum concentration of Selpercatinib can be increased when it is combined with Ketoconazole.
Captopril Captopril Selpercatinib may decrease the antihypertensive activities of Captopril.
Isoxsuprine Isoxsuprine The risk or severity of hypertension can be increased when Isoxsuprine is combined with Selpercatinib.
Vinblastine Vinblastine The serum concentration of Selpercatinib can be decreased when it is combined with Vinblastine.
Metoprolol Metoprolol Selpercatinib may decrease the antihypertensive activities of Metoprolol.
Hydroxyzine Hydroxyzine The risk or severity of QTc prolongation can be increased when Selpercatinib is combined with Hydroxyzine.
Aspirin Aspirin The risk or severity of hypertension can be increased when Acetylsalicylic acid is combined with Selpercatinib.
Salsalate Salsalate The risk or severity of hypertension can be increased when Salsalate is combined with Selpercatinib.
Diltiazem Diltiazem The serum concentration of Diltiazem can be increased when it is combined with Selpercatinib.
Nifedipine Nifedipine The serum concentration of Selpercatinib can be decreased when it is combined with Nifedipine.
Timolol Timolol Selpercatinib may decrease the antihypertensive activities of Timolol.
Verapamil Verapamil The serum concentration of Verapamil can be increased when it is combined with Selpercatinib.
Atenolol Atenolol Selpercatinib may decrease the antihypertensive activities of Atenolol.
Pindolol Pindolol Selpercatinib may decrease the antihypertensive activities of Pindolol.
Diflunisal Diflunisal The risk or severity of hypertension can be increased when Diflunisal is combined with Selpercatinib.
Piroxicam Piroxicam The serum concentration of Selpercatinib can be increased when it is combined with Piroxicam.
Etoposide Etoposide The serum concentration of Selpercatinib can be decreased when it is combined with Etoposide.
Indapamide Indapamide Selpercatinib may decrease the antihypertensive activities of Indapamide.
Dicloxacillin Dicloxacillin The serum concentration of Selpercatinib can be decreased when it is combined with Dicloxacillin.
Nafcillin Injection Nafcillin Injection The serum concentration of Selpercatinib can be decreased when it is combined with Nafcillin.
Labetalol Labetalol Selpercatinib may decrease the antihypertensive activities of Labetalol.
Guanabenz Guanabenz Selpercatinib may decrease the antihypertensive activities of Guanabenz.
Ketoprofen Ketoprofen The risk or severity of hypertension can be increased when Ketoprofen is combined with Selpercatinib.
Enalapril Enalapril Selpercatinib may decrease the antihypertensive activities of Enalapril.
Flurbiprofen Flurbiprofen The risk or severity of hypertension can be increased when Flurbiprofen is combined with Selpercatinib.
Amiodarone Amiodarone The serum concentration of Amiodarone can be increased when it is combined with Selpercatinib.
Buspirone Buspirone The risk or severity of hypertension can be increased when Buspirone is combined with Selpercatinib.
Lovastatin Lovastatin The serum concentration of Lovastatin can be increased when it is combined with Selpercatinib.
Ciprofloxacin Ciprofloxacin The serum concentration of Ciprofloxacin can be increased when it is combined with Selpercatinib.
Mesalamine Mesalamine The risk or severity of hypertension can be increased when Mesalazine is combined with Selpercatinib.
Diclofenac Diclofenac The serum concentration of Selpercatinib can be increased when it is combined with Diclofenac.
Oxiconazole Oxiconazole The serum concentration of Selpercatinib can be decreased when it is combined with Oxiconazole.
Fluoxetine Fluoxetine The risk or severity of QTc prolongation can be increased when Fluoxetine is combined with Selpercatinib.
Nimodipine Nimodipine Selpercatinib may decrease the antihypertensive activities of Nimodipine.
Clozapine Clozapine The serum concentration of Selpercatinib can be decreased when it is combined with Clozapine.
Clarithromycin Clarithromycin The serum concentration of Selpercatinib can be increased when it is combined with Clarithromycin.
Benazepril Benazepril Selpercatinib may decrease the antihypertensive activities of Benazepril.
Etodolac Etodolac The risk or severity of hypertension can be increased when Etodolac is combined with Selpercatinib.
Felodipine Felodipine Selpercatinib may decrease the antihypertensive activities of Felodipine.
Fosinopril Fosinopril Selpercatinib may decrease the antihypertensive activities of Fosinopril.
Nabumetone Nabumetone The risk or severity of hypertension can be increased when Nabumetone is combined with Selpercatinib.
Quinapril Quinapril Selpercatinib may decrease the antihypertensive activities of Quinapril.
Ramipril Ramipril Selpercatinib may decrease the antihypertensive activities of Ramipril.
Simvastatin Simvastatin The serum concentration of Simvastatin can be increased when it is combined with Selpercatinib.
Epoetin Alfa, Injection Epoetin Alfa, Injection The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Selpercatinib.
Amlodipine Amlodipine Selpercatinib may decrease the antihypertensive activities of Amlodipine.
Itraconazole Itraconazole The serum concentration of Selpercatinib can be increased when it is combined with Itraconazole.
Lisinopril Lisinopril Selpercatinib may decrease the antihypertensive activities of Lisinopril.
Oxaprozin Oxaprozin The risk or severity of hypertension can be increased when Oxaprozin is combined with Selpercatinib.
Rifabutin Rifabutin The serum concentration of Selpercatinib can be decreased when it is combined with Rifabutin.
Bisoprolol Bisoprolol Selpercatinib may decrease the antihypertensive activities of Bisoprolol.
Doxazosin Doxazosin Selpercatinib may decrease the antihypertensive activities of Doxazosin.
Terazosin Terazosin Selpercatinib may decrease the antihypertensive activities of Terazosin.
Isradipine Isradipine Selpercatinib may decrease the antihypertensive activities of Isradipine.
Omeprazole Omeprazole The serum concentration of Omeprazole can be decreased when it is combined with Selpercatinib.
Cisapride Cisapride The serum concentration of Cisapride can be increased when it is combined with Selpercatinib.
Fluvastatin Fluvastatin The serum concentration of Fluvastatin can be increased when it is combined with Selpercatinib.
Nizatidine Nizatidine The serum concentration of Selpercatinib can be decreased when it is combined with Nizatidine.
Fluvoxamine Fluvoxamine The serum concentration of Selpercatinib can be increased when it is combined with Fluvoxamine.
Nefazodone Nefazodone The serum concentration of Selpercatinib can be increased when it is combined with Nefazodone.
Losartan Losartan Selpercatinib may decrease the antihypertensive activities of Losartan.
Moexipril Moexipril Selpercatinib may decrease the antihypertensive activities of Moexipril.
Lansoprazole Lansoprazole The serum concentration of Lansoprazole can be decreased when it is combined with Selpercatinib.
Ifosfamide Injection Ifosfamide Injection The serum concentration of Ifosfamide can be decreased when it is combined with Selpercatinib.
Nicardipine Nicardipine The serum concentration of Nicardipine can be increased when it is combined with Selpercatinib.
Metformin Metformin The excretion of Metformin can be decreased when combined with Selpercatinib.
Nisoldipine Nisoldipine Selpercatinib may decrease the antihypertensive activities of Nisoldipine.
Anastrozole Anastrozole The serum concentration of Anastrozole can be increased when it is combined with Selpercatinib.
Indinavir Indinavir The serum concentration of Selpercatinib can be increased when it is combined with Indinavir.
Ritonavir Ritonavir The serum concentration of Selpercatinib can be increased when it is combined with Ritonavir.
Clomipramine Clomipramine The risk or severity of hypertension can be increased when Clomipramine is combined with Selpercatinib.
Zafirlukast Zafirlukast The serum concentration of Zafirlukast can be increased when it is combined with Selpercatinib.
Mirtazapine Mirtazapine The risk or severity of hypertension can be increased when Mirtazapine is combined with Selpercatinib.
Trandolapril Trandolapril Selpercatinib may decrease the antihypertensive activities of Trandolapril.
Topiramate Topiramate The serum concentration of Selpercatinib can be decreased when it is combined with Topiramate.
Valsartan Valsartan Selpercatinib may decrease the antihypertensive activities of Valsartan.
Nelfinavir Nelfinavir The serum concentration of Selpercatinib can be increased when it is combined with Nelfinavir.
Carvedilol Carvedilol Selpercatinib may decrease the antihypertensive activities of Carvedilol.
Selegiline Selegiline The serum concentration of Selpercatinib can be increased when it is combined with Selegiline.
Propafenone Propafenone The risk or severity of hypertension can be increased when Propafenone is combined with Selpercatinib.
Irbesartan Irbesartan The serum concentration of Irbesartan can be increased when it is combined with Selpercatinib.
Finasteride Finasteride The risk or severity of hypertension can be increased when Finasteride is combined with Selpercatinib.
Quetiapine Quetiapine The risk or severity of hypertension can be increased when Quetiapine is combined with Selpercatinib.
Paroxetine Paroxetine The serum concentration of Selpercatinib can be increased when it is combined with Paroxetine.
Efavirenz Efavirenz The serum concentration of Selpercatinib can be decreased when it is combined with Efavirenz.
Pioglitazone Pioglitazone The serum concentration of Pioglitazone can be increased when it is combined with Selpercatinib.
Celecoxib Celecoxib The serum concentration of Selpercatinib can be increased when it is combined with Celecoxib.
Rosiglitazone Rosiglitazone The serum concentration of Rosiglitazone can be increased when it is combined with Selpercatinib.
Thalidomide Thalidomide The serum concentration of Selpercatinib can be decreased when it is combined with Thalidomide.
Aluminum Hydroxide Aluminum Hydroxide The serum concentration of Selpercatinib can be decreased when it is combined with Aluminum hydroxide.
Balsalazide Balsalazide The risk or severity of hypertension can be increased when Balsalazide is combined with Selpercatinib.
Rabeprazole Rabeprazole The serum concentration of Selpercatinib can be decreased when it is combined with Rabeprazole.
Terbinafine Terbinafine The serum concentration of Terbinafine can be decreased when it is combined with Selpercatinib.

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