Selpercatinib

Selpercatinib is used to treat a certain type of non-small cell lung cancer (NSCLC) in adults that has spread to other parts of the body in adults. It is also used to treat a certain type of thyroid cancer in adults and children 12 years of age and older that has spread to other parts of the body. Selpercatinib is also used to treat another type of thyroid cancer that has spread to other parts of the body in adults and children 12 years of age and older who have been treated unsuccessfully with radioactive iodine. Selpercatinib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps slow or stop the spread of cancer cells.

Selpercatinib comes as a capsule to take by mouth. It is usually taken twice daily (every 12 hours) with or without food. Take selpercatinib at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take selpercatinib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the capsules whole; do not open, chew, or crush them.

If you vomit after taking selpercatinib, do not take another dose. Continue your regular dosing schedule.

Your doctor may decrease your dose, or interrupt or discontinue your treatment. This depends on how well the medication works for you and the side effects you experience. Talk to your doctor about how you are feeling during your treatment. Continue to take selpercatinib even if you feel well. Do not stop taking selpercatinib without talking to your doctor.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking selpercatinib,

• tell your doctor and pharmacist if you are allergic to selpercatinib, any other medications, or any of the ingredients in selpercatinib capsules. Ask your pharmacist for a list of the ingredients.

• tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antifungals such as fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole, and voriconazole (Vfend); aprepitant (Emend); carbamazepine (Carbatrol, Tegretol, Equetro, others); clarithromycin (Biaxin, in Prevpac); diltiazem (Cardizem, Cartia, Tiazac, others); erythromycin (E.E.S., E-Mycin, Erythrocin); certain medications for human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) including efavirenz (Sustiva), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, in Kaletra), and saquinavir (Invirase); nefazodone; phenobarbital; phenytoin (Dilantin, Phenytek); pioglitazone (Actos); quinidine (in Nuedexta); repaglinide (Prandin); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane, in Rifamate, in Rifater); and verapamil (Calan, Verelan, others). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with selpercatinib, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

• if you are taking an H₂ blocker medication for indigestion, heartburn, or ulcers such as cimetidine (Tagamet), famotidine (Pepcid), nizatidine (Axid), or ranitidine (Zantac), take selpercatinib at least 2 hours before or 10 hours after taking one of these medications.

• if you are taking an antacid that contains aluminum, magnesium, calcium, or simethicone; or buffered medications such as buffered aspirin, take selpercatinib at least 2 hours before or at least 2 hours after you take one of these medications.

• if you are taking a proton-pump inhibitor such as esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), and rabeprazole (AcipHex), take each dose of selpercatinib along with food.

• tell your doctor what herbal products you are taking, especially St. John's wort.

• tell your doctor if you have or have ever had a slow, fast, or irregular heartbeat; a prolonged QT interval (a rare heart problem that may cause irregular heartbeat, fainting, or sudden death); high blood pressure; bleeding problems; or kidney or liver disease.

• tell your doctor if you are pregnant, plan to become pregnant, or if you plan on fathering a child. You should not become pregnant while you are taking selpercatinib. If you are female, you will need to take a pregnancy test before you start treatment and use birth control to prevent pregnancy during your treatment with selpercatinib and for 1 week after your final dose. If you are male, you and your female partner should use birth control during your treatment with selpercatinib and for 1 week after your final dose. If you or your partner become pregnant while taking selpercatinib, call your doctor immediately. Selpercatinib can cause fetal harm.

• tell your doctor if you are breastfeeding. You should not breastfeed while you are taking selpercatinib and for 1 week after your final dose.

• you should know that this medication may decrease fertility in men and women. Talk to your doctor about the risks of taking selpercatinib.

• if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking selpercatinib. Your doctor may tell you not to take selpercatinib 7 days before your surgery or procedure and will tell you when you should start taking the medication again.

Do not eat grapefruit or drink grapefruit juice while taking this medication.

Take the missed dose as soon as you remember it. However, if it is within 6 hours of your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

• Selpercatinib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • dry mouth

  • diarrhea

  • constipation

  • nausea

  • vomiting

  • stomach pain

  • headache

  • tiredness

  • cough

  • shortness of breath

  • swelling of your arms, legs, hands, and feet

• Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

  • pain in the right upper part of the stomach; unusual bruising or bleeding; dark urine; or yellowing of the skin and eye

  • heart palpitations

  • dizziness or lightheadedness

  • fainting

  • coughing up or vomiting blood or material that looks like coffee grounds; unusual bleeding or bruising, pink; red, or dark brown urine; or red or tarry black bowel movements

  • nausea; vomiting; shortness of breath; muscle cramps; weakness; seizures; or swelling of arms and legs

  • fever, rash, or joint or muscle pain

• Selpercatinib may cause the bones to stop growing too soon in teenagers who are still growing. Talk to your child's doctor about the risks of giving this medication to your child.

• Selpercatinib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

• If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor and the laboratory. Your doctor will check your blood pressure regularly and order certain lab tests before and during your treatment to check your body's response to selpercatinib.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug	Interaction
Repaglinide	Repaglinide The serum concentration of Repaglinide can be increased when it is combined with Selpercatinib.
Montelukast	Montelukast The serum concentration of Montelukast can be increased when it is combined with Selpercatinib.
Atorvastatin	Atorvastatin The serum concentration of Atorvastatin can be decreased when it is combined with Selpercatinib.
Calcium Carbonate	Calcium Carbonate The serum concentration of Selpercatinib can be decreased when it is combined with Calcium carbonate.
Candesartan	Candesartan Selpercatinib may decrease the antihypertensive activities of Candesartan.
Guanfacine	Guanfacine Selpercatinib may decrease the antihypertensive activities of Guanfacine.
Magnesium Hydroxide	Magnesium Hydroxide The serum concentration of Selpercatinib can be decreased when it is combined with Magnesium hydroxide.
Magnesium Oxide	Magnesium Oxide The serum concentration of Selpercatinib can be decreased when it is combined with Magnesium oxide.
Methylergonovine	Methylergonovine The risk or severity of hypertension can be increased when Methylergometrine is combined with Selpercatinib.
Naratriptan	Naratriptan The risk or severity of hypertension can be increased when Naratriptan is combined with Selpercatinib.
Olsalazine	Olsalazine The risk or severity of hypertension can be increased when Olsalazine is combined with Selpercatinib.
Paregoric	Paregoric The serum concentration of Morphine can be increased when it is combined with Selpercatinib.
Penbutolol	Penbutolol Selpercatinib may decrease the antihypertensive activities of Acebutolol.
Ranitidine	Ranitidine The serum concentration of Selpercatinib can be decreased when it is combined with Ranitidine.
Reserpine	Reserpine The serum concentration of Reserpine can be decreased when it is combined with Selpercatinib.
Rizatriptan	Rizatriptan The risk or severity of hypertension can be increased when Rizatriptan is combined with Selpercatinib.
Sumatriptan	Sumatriptan The risk or severity of hypertension can be increased when Sumatriptan is combined with Selpercatinib.
Zolmitriptan	Zolmitriptan The risk or severity of hypertension can be increased when Zolmitriptan is combined with Selpercatinib.
Famotidine Injection	Famotidine Injection The serum concentration of Selpercatinib can be decreased when it is combined with Famotidine.
Levofloxacin Injection	Levofloxacin Injection The excretion of Levofloxacin can be decreased when combined with Selpercatinib.
Meperidine Injection	Meperidine Injection The serum concentration of Selpercatinib can be decreased when it is combined with Meperidine.
Methylprednisolone Injection	Methylprednisolone Injection The serum concentration of Selpercatinib can be decreased when it is combined with Methylprednisolone.
Morphine Injection	Morphine Injection The serum concentration of Morphine can be increased when it is combined with Selpercatinib.
Zidovudine Injection	Zidovudine Injection The serum concentration of Zidovudine can be increased when it is combined with Selpercatinib.
Altretamine	Altretamine The risk or severity of hypertension can be increased when Amphetamine is combined with Selpercatinib.
Cyclosporine	Cyclosporine The risk or severity of hypertension can be increased when Cyclosporine is combined with Selpercatinib.
Torsemide	Torsemide The serum concentration of Torasemide can be increased when it is combined with Selpercatinib.
Olanzapine	Olanzapine The serum concentration of Selpercatinib can be decreased when it is combined with Olanzapine.
Eprosartan	Eprosartan Selpercatinib may decrease the antihypertensive activities of Eprosartan.
Hydroxychloroquine	Hydroxychloroquine The serum concentration of Hydroxychloroquine can be increased when it is combined with Selpercatinib.
Meloxicam	Meloxicam The risk or severity of hypertension can be increased when Meloxicam is combined with Selpercatinib.
Orlistat	Orlistat The serum concentration of Selpercatinib can be decreased when it is combined with Orlistat.
Oxcarbazepine	Oxcarbazepine The serum concentration of Selpercatinib can be decreased when it is combined with Oxcarbazepine.
Pantoprazole	Pantoprazole The serum concentration of Selpercatinib can be decreased when it is combined with Pantoprazole.
Telmisartan	Telmisartan Selpercatinib may decrease the antihypertensive activities of Telmisartan.
Temozolomide	Temozolomide The serum concentration of Selpercatinib can be decreased when it is combined with Temozolomide.
Linezolid	Linezolid The risk or severity of hypertension can be increased when Linezolid is combined with Selpercatinib.
Trimipramine	Trimipramine The risk or severity of hypertension can be increased when Trimipramine is combined with Selpercatinib.
Modafinil	Modafinil The serum concentration of Selpercatinib can be increased when it is combined with Modafinil.
Perindopril	Perindopril Selpercatinib may decrease the antihypertensive activities of Perindopril.
Choline Magnesium Trisalicylate	Choline Magnesium Trisalicylate The risk or severity of hypertension can be increased when Choline magnesium trisalicylate is combined with Selpercatinib.
Dutasteride	Dutasteride The risk or severity of hypertension can be increased when Dutasteride is combined with Selpercatinib.
Epinephrine Injection	Epinephrine Injection The risk or severity of hypertension can be increased when Epinephrine is combined with Selpercatinib.
Eplerenone	Eplerenone Selpercatinib may decrease the antihypertensive activities of Eplerenone.
Olmesartan	Olmesartan Selpercatinib may decrease the antihypertensive activities of Olmesartan.
Aripiprazole	Aripiprazole The risk or severity of hypertension can be increased when Aripiprazole is combined with Selpercatinib.
Atomoxetine	Atomoxetine The risk or severity of hypertension can be increased when Atomoxetine is combined with Selpercatinib.
Dexmethylphenidate	Dexmethylphenidate The risk or severity of hypertension can be increased when Dexmethylphenidate is combined with Selpercatinib.
Teriparatide Injection	Teriparatide Injection The therapeutic efficacy of Teriparatide can be decreased when used in combination with Selpercatinib.
Atazanavir	Atazanavir The serum concentration of Selpercatinib can be increased when it is combined with Atazanavir.
Almotriptan	Almotriptan The serum concentration of Selpercatinib can be increased when it is combined with Almotriptan.
Eletriptan	Eletriptan The serum concentration of Selpercatinib can be decreased when it is combined with Eletriptan.
Emtricitabine	Emtricitabine The excretion of Emtricitabine can be decreased when combined with Selpercatinib.
Tadalafil	Tadalafil Selpercatinib may decrease the antihypertensive activities of Tadalafil.
Frovatriptan	Frovatriptan The risk or severity of hypertension can be increased when Frovatriptan is combined with Selpercatinib.
Progesterone	Progesterone The serum concentration of Selpercatinib can be increased when it is combined with Progesterone.
Apomorphine Injection	Apomorphine Injection The serum concentration of Apomorphine can be increased when it is combined with Selpercatinib.
Darbepoetin Alfa Injection	Darbepoetin Alfa Injection The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Selpercatinib.
Protriptyline	Protriptyline The risk or severity of hypertension can be increased when Protriptyline is combined with Selpercatinib.
Rifaximin	Rifaximin The serum concentration of Selpercatinib can be decreased when it is combined with Rifaximin.
Bosentan	Bosentan The serum concentration of Bosentan can be decreased when it is combined with Selpercatinib.
Erlotinib	Erlotinib The serum concentration of Erlotinib can be increased when it is combined with Selpercatinib.
Eszopiclone	Eszopiclone The serum concentration of Eszopiclone can be increased when it is combined with Selpercatinib.
Ganciclovir	Ganciclovir The excretion of Ganciclovir can be decreased when combined with Selpercatinib.
Solifenacin	Solifenacin The risk or severity of hypertension can be increased when Solifenacin is combined with Selpercatinib.
Dextroamphetamine	Dextroamphetamine The risk or severity of hypertension can be increased when Amphetamine is combined with Selpercatinib.
Isocarboxazid	Isocarboxazid The risk or severity of hypertension can be increased when Isocarboxazid is combined with Selpercatinib.
Fentanyl	Fentanyl The risk or severity of hypertension can be increased when Fentanyl is combined with Selpercatinib.
Deferasirox	Deferasirox The serum concentration of Selpercatinib can be decreased when it is combined with Deferasirox.
Phenylephrine	Phenylephrine The risk or severity of hypertension can be increased when Phenylephrine is combined with Selpercatinib.
Felbamate	Felbamate The serum concentration of Selpercatinib can be decreased when it is combined with Felbamate.
Ranolazine	Ranolazine The serum concentration of Selpercatinib can be increased when it is combined with Ranolazine.
Rasagiline	Rasagiline The risk or severity of hypertension can be increased when Rasagiline is combined with Selpercatinib.
Imatinib	Imatinib The serum concentration of Imatinib can be increased when it is combined with Selpercatinib.
Sitagliptin	Sitagliptin The serum concentration of Sitagliptin can be increased when it is combined with Selpercatinib.
Albuterol	Albuterol The risk or severity of hypertension can be increased when Salbutamol is combined with Selpercatinib.
Paliperidone	Paliperidone The risk or severity of hypertension can be increased when Paliperidone is combined with Selpercatinib.
Aliskiren	Aliskiren Selpercatinib may decrease the antihypertensive activities of Aliskiren.
Lisdexamfetamine	Lisdexamfetamine The risk or severity of hypertension can be increased when Lisdexamfetamine is combined with Selpercatinib.
Sorafenib	Sorafenib The serum concentration of Sorafenib can be increased when it is combined with Selpercatinib.
Lapatinib	Lapatinib The serum concentration of Lapatinib can be increased when it is combined with Selpercatinib.
Armodafinil	Armodafinil The serum concentration of Selpercatinib can be decreased when it is combined with Armodafinil.
Bexarotene	Bexarotene The serum concentration of Selpercatinib can be decreased when it is combined with Bexarotene.
Budesonide	Budesonide The serum concentration of Selpercatinib can be decreased when it is combined with Budesonide.
Desmopressin	Desmopressin The risk or severity of hypertension can be increased when Desmopressin is combined with Selpercatinib.
Etravirine	Etravirine The serum concentration of Selpercatinib can be decreased when it is combined with Etravirine.
Nebivolol	Nebivolol Selpercatinib may decrease the antihypertensive activities of Nebivolol.
Tretinoin	Tretinoin The serum concentration of Tretinoin can be increased when it is combined with Selpercatinib.
Flecainide	Flecainide The excretion of Flecainide can be decreased when combined with Selpercatinib.
Mitotane	Mitotane The serum concentration of Selpercatinib can be decreased when it is combined with Mitotane.
Rufinamide	Rufinamide The serum concentration of Selpercatinib can be decreased when it is combined with Rufinamide.
Eltrombopag	Eltrombopag The serum concentration of Eltrombopag can be increased when it is combined with Selpercatinib.
Dexlansoprazole	Dexlansoprazole The serum concentration of Selpercatinib can be decreased when it is combined with Dexlansoprazole.
Betaxolol	Betaxolol Selpercatinib may decrease the antihypertensive activities of Betaxolol.
Iloperidone	Iloperidone The risk or severity of hypertension can be increased when Iloperidone is combined with Selpercatinib.
Dronedarone	Dronedarone The risk or severity of hypertension can be increased when Dronedarone is combined with Selpercatinib.
Topotecan	Topotecan The serum concentration of Topotecan can be decreased when it is combined with Selpercatinib.
Pazopanib	Pazopanib The serum concentration of Pazopanib can be increased when it is combined with Selpercatinib.
Asenapine	Asenapine The serum concentration of Selpercatinib can be decreased when it is combined with Asenapine.
Pitavastatin	Pitavastatin The serum concentration of Pitavastatin can be increased when it is combined with Selpercatinib.
Tocilizumab Injection	Tocilizumab Injection The serum concentration of Selpercatinib can be decreased when it is combined with Tocilizumab.
Cabazitaxel Injection	Cabazitaxel Injection The serum concentration of Cabazitaxel can be increased when it is combined with Selpercatinib.
Lurasidone	Lurasidone The risk or severity of hypertension can be increased when Lurasidone is combined with Selpercatinib.
Acetaminophen Injection	Acetaminophen Injection The serum concentration of Acetaminophen can be decreased when it is combined with Selpercatinib.
Vilazodone	Vilazodone The risk or severity of hypertension can be increased when Vilazodone is combined with Selpercatinib.
Terbutaline Injection	Terbutaline Injection The risk or severity of hypertension can be increased when Terbutaline is combined with Selpercatinib.
Telaprevir	Telaprevir The serum concentration of Selpercatinib can be increased when it is combined with Glecaprevir.
Potassium Iodide	Potassium Iodide The therapeutic efficacy of Potassium Iodide can be decreased when used in combination with Selpercatinib.
Cyclophosphamide Injection	Cyclophosphamide Injection The serum concentration of Cyclophosphamide can be decreased when it is combined with Selpercatinib.
Clobazam	Clobazam The serum concentration of Selpercatinib can be decreased when it is combined with Clobazam.
Vemurafenib	Vemurafenib The serum concentration of Selpercatinib can be decreased when it is combined with Vemurafenib.
Crizotinib	Crizotinib The serum concentration of Selpercatinib can be increased when it is combined with Crizotinib.
Cabergoline	Cabergoline The risk or severity of hypertension can be increased when Cabergoline is combined with Selpercatinib.
Ambrisentan	Ambrisentan Selpercatinib may decrease the antihypertensive activities of Ambrisentan.
Enzalutamide	Enzalutamide The serum concentration of Enzalutamide can be decreased when it is combined with Selpercatinib.
Mirabegron	Mirabegron The risk or severity of hypertension can be increased when Mirabegron is combined with Selpercatinib.
Corticotropin, Repository Injection	Corticotropin, Repository Injection The serum concentration of Selpercatinib can be decreased when it is combined with Corticotropin.
Ponatinib	Ponatinib The serum concentration of Ponatinib can be increased when it is combined with Selpercatinib.
Apixaban	Apixaban The serum concentration of Apixaban can be increased when it is combined with Selpercatinib.
Dabrafenib	Dabrafenib The serum concentration of Dabrafenib can be decreased when it is combined with Selpercatinib.
Trametinib	Trametinib The serum concentration of Selpercatinib can be decreased when it is combined with Trametinib.
Levomilnacipran	Levomilnacipran The serum concentration of Levomilnacipran can be increased when it is combined with Selpercatinib.
Vortioxetine	Vortioxetine The serum concentration of Selpercatinib can be increased when it is combined with Vortioxetine.
Perampanel	Perampanel The serum concentration of Selpercatinib can be decreased when it is combined with Perampanel.
Ketorolac Injection	Ketorolac Injection The serum concentration of Selpercatinib can be increased when it is combined with Ketorolac.
Droxidopa	Droxidopa The risk or severity of hypertension can be increased when Droxidopa is combined with Selpercatinib.
Siltuximab Injection	Siltuximab Injection The serum concentration of Selpercatinib can be decreased when it is combined with Siltuximab.
Eslicarbazepine	Eslicarbazepine The serum concentration of Selpercatinib can be decreased when it is combined with Eslicarbazepine.
Idelalisib	Idelalisib The serum concentration of Selpercatinib can be increased when it is combined with Idelalisib.
Testosterone Injection	Testosterone Injection The serum concentration of Selpercatinib can be decreased when it is combined with Testosterone.
Oritavancin Injection	Oritavancin Injection The serum concentration of Selpercatinib can be decreased when it is combined with Oritavancin.
Suvorexant	Suvorexant The serum concentration of Selpercatinib can be increased when it is combined with Suvorexant.
Methamphetamine	Methamphetamine The risk or severity of hypertension can be increased when Metamfetamine is combined with Selpercatinib.
Riociguat	Riociguat The serum concentration of Riociguat can be increased when it is combined with Selpercatinib.
Risperidone Injection	Risperidone Injection The risk or severity of hypertension can be increased when Risperidone is combined with Selpercatinib.
Lenvatinib	Lenvatinib The serum concentration of Selpercatinib can be decreased when it is combined with Lenvatinib.
Haloperidol Injection	Haloperidol Injection The risk or severity of QTc prolongation can be increased when Selpercatinib is combined with Haloperidol.
Isavuconazonium Injection	Isavuconazonium Injection The serum concentration of Selpercatinib can be decreased when it is combined with Isavuconazonium.
Macitentan	Macitentan Selpercatinib may decrease the antihypertensive activities of Macitentan.
Flibanserin	Flibanserin The risk or severity of hypertension can be increased when Flibanserin is combined with Selpercatinib.
Prednisolone	Prednisolone The serum concentration of Selpercatinib can be decreased when it is combined with Prednisolone.
Brexpiprazole	Brexpiprazole The risk or severity of hypertension can be increased when Brexpiprazole is combined with Selpercatinib.
Ziprasidone Injection	Ziprasidone Injection The risk or severity of QTc prolongation can be increased when Ziprasidone is combined with Selpercatinib.
Cariprazine	Cariprazine The risk or severity of hypertension can be increased when Cariprazine is combined with Selpercatinib.
Osimertinib	Osimertinib The serum concentration of Selpercatinib can be decreased when it is combined with Osimertinib.
Rifapentine	Rifapentine The serum concentration of Selpercatinib can be decreased when it is combined with Rifapentine.
Lesinurad	Lesinurad The serum concentration of Selpercatinib can be decreased when it is combined with Lesinurad.
Dexamethasone Injection	Dexamethasone Injection The serum concentration of Selpercatinib can be decreased when it is combined with Dexamethasone.
Cobicistat	Cobicistat The serum concentration of Selpercatinib can be increased when it is combined with Cobicistat.
Midodrine	Midodrine The risk or severity of hypertension can be increased when Midodrine is combined with Selpercatinib.
Selexipag	Selexipag The serum concentration of Selexipag can be increased when it is combined with Selpercatinib.
Furosemide Injection	Furosemide Injection Selpercatinib may decrease the antihypertensive activities of Furosemide.
Parathyroid Hormone Injection	Parathyroid Hormone Injection The therapeutic efficacy of Parathyroid hormone can be decreased when used in combination with Selpercatinib.
Brigatinib	Brigatinib The serum concentration of Brigatinib can be decreased when it is combined with Selpercatinib.
Doxepin (Insomnia)	Doxepin (Insomnia) The serum concentration of Selpercatinib can be decreased when it is combined with Doxepin.
Safinamide	Safinamide The risk or severity of hypertension can be increased when Safinamide is combined with Selpercatinib.
Sarilumab Injection	Sarilumab Injection The serum concentration of Selpercatinib can be decreased when it is combined with Sarilumab.
Midostaurin	Midostaurin The serum concentration of Selpercatinib can be decreased when it is combined with Midostaurin.
Abaloparatide Injection	Abaloparatide Injection The therapeutic efficacy of Abaloparatide can be decreased when used in combination with Selpercatinib.
Enasidenib	Enasidenib The serum concentration of Enasidenib can be decreased when it is combined with Selpercatinib.
Aprepitant/Fosaprepitant Injection	Aprepitant/Fosaprepitant Injection The serum concentration of Selpercatinib can be decreased when it is combined with Fosaprepitant.
Delafloxacin	Delafloxacin The serum concentration of Selpercatinib can be decreased when it is combined with Delafloxacin.
Abemaciclib	Abemaciclib The excretion of Abemaciclib can be decreased when combined with Selpercatinib.
Acalabrutinib	Acalabrutinib The serum concentration of Selpercatinib can be increased when it is combined with Acalabrutinib.
Buprenorphine Injection	Buprenorphine Injection The serum concentration of Buprenorphine can be increased when it is combined with Selpercatinib.
Apalutamide	Apalutamide The serum concentration of Apalutamide can be decreased when it is combined with Selpercatinib.
Lofexidine	Lofexidine Selpercatinib may decrease the antihypertensive activities of Lofexidine.
Ivosidenib	Ivosidenib The serum concentration of Selpercatinib can be decreased when it is combined with Ivosidenib.
Elagolix	Elagolix The serum concentration of Elagolix can be increased when it is combined with Selpercatinib.
Cannabidiol	Cannabidiol The risk or severity of hypertension can be increased when Cannabidiol is combined with Selpercatinib.
Glasdegib	Glasdegib The serum concentration of Glasdegib can be increased when it is combined with Selpercatinib.
Lorlatinib	Lorlatinib The serum concentration of Lorlatinib can be decreased when it is combined with Selpercatinib.
Methoxy Polyethylene Glycol-Epoetin Beta Injection	Methoxy Polyethylene Glycol-Epoetin Beta Injection The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Selpercatinib.
Paclitaxel (with albumin) Injection	Paclitaxel (with albumin) Injection The serum concentration of Paclitaxel can be decreased when it is combined with Selpercatinib.
Rifamycin	Rifamycin The serum concentration of Selpercatinib can be decreased when it is combined with Rifamycin.
Siponimod	Siponimod The risk or severity of hypertension can be increased when Siponimod is combined with Selpercatinib.
Acyclovir Ophthalmic	Acyclovir Ophthalmic The excretion of Acyclovir can be decreased when combined with Selpercatinib.
Esomeprazole Injection	Esomeprazole Injection The serum concentration of Selpercatinib can be decreased when it is combined with Esomeprazole.
Alpelisib	Alpelisib The serum concentration of Selpercatinib can be decreased when it is combined with Alpelisib.
Solriamfetol	Solriamfetol The risk or severity of hypertension can be increased when Solriamfetol is combined with Selpercatinib.
Entrectinib	Entrectinib The risk or severity of QTc prolongation can be increased when Selpercatinib is combined with Entrectinib.
Pexidartinib	Pexidartinib Selpercatinib may increase the hepatotoxic activities of Pexidartinib.
Istradefylline	Istradefylline The serum concentration of Istradefylline can be increased when it is combined with Selpercatinib.
Pitolisant	Pitolisant The serum concentration of Selpercatinib can be decreased when it is combined with Pitolisant.
Lefamulin	Lefamulin Lefamulin may increase the QTc-prolonging activities of Selpercatinib.
Phenytoin Injection	Phenytoin Injection The serum concentration of Phenytoin can be decreased when it is combined with Selpercatinib.
Fosphenytoin Injection	Fosphenytoin Injection The serum concentration of Fosphenytoin can be decreased when it is combined with Selpercatinib.
Cenobamate	Cenobamate The serum concentration of Selpercatinib can be decreased when it is combined with Cenobamate.
Ozanimod	Ozanimod The serum concentration of Ozanimod can be increased when it is combined with Selpercatinib.
Selumetinib	Selumetinib The serum concentration of Selumetinib can be increased when it is combined with Selpercatinib.
Tucatinib	Tucatinib The metabolism of Tucatinib can be decreased when combined with Selpercatinib.
Remdesivir Injection	Remdesivir Injection The serum concentration of Selpercatinib can be increased when it is combined with Remdesivir.
Pralsetinib	Pralsetinib The serum concentration of Selpercatinib can be increased when it is combined with Pralsetinib.
Satralizumab-mwge Injection	Satralizumab-mwge Injection The serum concentration of Selpercatinib can be decreased when it is combined with Satralizumab.
Naxitamab-gqgk Injection	Naxitamab-gqgk Injection The risk or severity of hypertension can be increased when Selpercatinib is combined with Naxitamab.
Theophylline	Theophylline The serum concentration of Theophylline can be increased when it is combined with Selpercatinib.
Fenoprofen	Fenoprofen The risk or severity of hypertension can be increased when Fenoprofen is combined with Selpercatinib.
Indomethacin	Indomethacin The risk or severity of hypertension can be increased when Indomethacin is combined with Selpercatinib.
Mefenamic Acid	Mefenamic Acid The risk or severity of hypertension can be increased when Mefenamic acid is combined with Selpercatinib.
Naproxen	Naproxen The serum concentration of Selpercatinib can be increased when it is combined with Naproxen.
Tolmetin	Tolmetin The risk or severity of hypertension can be increased when Tolmetin is combined with Selpercatinib.
Sulindac	Sulindac The risk or severity of hypertension can be increased when Sulindac is combined with Selpercatinib.
Trazodone	Trazodone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Selpercatinib.
Sodium Bicarbonate	Sodium Bicarbonate The serum concentration of Selpercatinib can be decreased when it is combined with Sodium bicarbonate.
Phenobarbital	Phenobarbital The serum concentration of Selpercatinib can be decreased when it is combined with Phenobarbital.
Primidone	Primidone The serum concentration of Selpercatinib can be decreased when it is combined with Primidone.
Diethylpropion	Diethylpropion The risk or severity of hypertension can be increased when Diethylpropion is combined with Selpercatinib.
Chlorpromazine	Chlorpromazine The risk or severity of hypertension can be increased when Chlorpromazine is combined with Selpercatinib.
Phenoxybenzamine	Phenoxybenzamine Selpercatinib may decrease the antihypertensive activities of Phenoxybenzamine.
Bromocriptine	Bromocriptine The risk or severity of hypertension can be increased when Bromocriptine is combined with Selpercatinib.
Metaproterenol	Metaproterenol The risk or severity of hypertension can be increased when Orciprenaline is combined with Selpercatinib.
Tranylcypromine	Tranylcypromine The risk or severity of hypertension can be increased when Tranylcypromine is combined with Selpercatinib.
Phenelzine	Phenelzine The risk or severity of hypertension can be increased when Phenelzine is combined with Selpercatinib.
Ergoloid Mesylates	Ergoloid Mesylates The risk or severity of hypertension can be increased when Ergoloid mesylate is combined with Selpercatinib.
Thioridazine	Thioridazine The risk or severity of hypertension can be increased when Thioridazine is combined with Selpercatinib.
Trifluoperazine	Trifluoperazine The risk or severity of hypertension can be increased when Trifluoperazine is combined with Selpercatinib.
Dapsone	Dapsone The serum concentration of Dapsone can be increased when it is combined with Selpercatinib.
Sulfadiazine	Sulfadiazine The serum concentration of Sulfadiazine can be increased when it is combined with Selpercatinib.
Methadone	Methadone The serum concentration of Methadone can be increased when it is combined with Selpercatinib.
Ibuprofen	Ibuprofen The serum concentration of Selpercatinib can be increased when it is combined with Ibuprofen.
Phentermine	Phentermine The risk or severity of hypertension can be increased when Phentermine is combined with Selpercatinib.
Methylphenidate	Methylphenidate The risk or severity of hypertension can be increased when Methylphenidate is combined with Selpercatinib.
Amoxapine	Amoxapine The risk or severity of hypertension can be increased when Amoxapine is combined with Selpercatinib.
Sulfasalazine	Sulfasalazine The risk or severity of hypertension can be increased when Sulfasalazine is combined with Selpercatinib.
Hydrocortisone	Hydrocortisone The serum concentration of Selpercatinib can be decreased when it is combined with Hydrocortisone.
Pyridostigmine	Pyridostigmine The serum concentration of Selpercatinib can be decreased when it is combined with Pyridostigmine.
Carbamazepine	Carbamazepine The serum concentration of Selpercatinib can be decreased when it is combined with Carbamazepine.
Methyldopa	Methyldopa Selpercatinib may decrease the antihypertensive activities of Methyldopa.
Clonidine	Clonidine Selpercatinib may decrease the antihypertensive activities of Clonidine.
Prazosin	Prazosin Selpercatinib may decrease the antihypertensive activities of Prazosin.
Hydralazine	Hydralazine Selpercatinib may decrease the antihypertensive activities of Hydralazine.
Cimetidine	Cimetidine The serum concentration of Cimetidine can be decreased when it is combined with Selpercatinib.
Loperamide	Loperamide The serum concentration of Loperamide can be increased when it is combined with Selpercatinib.
Promethazine	Promethazine The serum concentration of Selpercatinib can be decreased when it is combined with Promethazine.
Meclofenamate	Meclofenamate The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Selpercatinib.
Daunorubicin	Daunorubicin The serum concentration of Selpercatinib can be decreased when it is combined with Daunorubicin.
Griseofulvin	Griseofulvin The serum concentration of Selpercatinib can be decreased when it is combined with Griseofulvin.
Chloroquine	Chloroquine The serum concentration of Chloroquine can be increased when it is combined with Selpercatinib.
Quinine	Quinine The serum concentration of Quinine can be decreased when it is combined with Selpercatinib.
Calcitriol	Calcitriol The serum concentration of Selpercatinib can be decreased when it is combined with Calcitriol.
Sulfinpyrazone	Sulfinpyrazone The serum concentration of Selpercatinib can be decreased when it is combined with Sulfinpyrazone.
Chlorothiazide	Chlorothiazide Selpercatinib may decrease the antihypertensive activities of Chlorothiazide.
Chlorthalidone	Chlorthalidone Selpercatinib may decrease the antihypertensive activities of Chlorthalidone.
Metolazone	Metolazone Selpercatinib may decrease the antihypertensive activities of Metolazone.
Secobarbital	Secobarbital The serum concentration of Selpercatinib can be decreased when it is combined with Secobarbital.
Desipramine	Desipramine The risk or severity of hypertension can be increased when Desipramine is combined with Selpercatinib.
Amitriptyline	Amitriptyline The serum concentration of Selpercatinib can be increased when it is combined with Amitriptyline.
Imipramine	Imipramine The risk or severity of hypertension can be increased when Imipramine is combined with Selpercatinib.
Probenecid	Probenecid The serum concentration of Selpercatinib can be decreased when it is combined with Probenecid.
Quinidine	Quinidine The serum concentration of Selpercatinib can be increased when it is combined with Quinidine.
Procainamide	Procainamide The excretion of Procainamide can be decreased when combined with Selpercatinib.
Rifampin	Rifampin The serum concentration of Selpercatinib can be decreased when it is combined with Rifampicin.
Tamoxifen	Tamoxifen The serum concentration of Selpercatinib can be decreased when it is combined with Tamoxifen.
Levothyroxine	Levothyroxine The therapeutic efficacy of Levothyroxine can be decreased when used in combination with Selpercatinib.
Liothyronine	Liothyronine The therapeutic efficacy of Liothyronine can be decreased when used in combination with Selpercatinib.
Methimazole	Methimazole The therapeutic efficacy of Methimazole can be decreased when used in combination with Selpercatinib.
Propylthiouracil	Propylthiouracil The therapeutic efficacy of Propylthiouracil can be decreased when used in combination with Selpercatinib.
Tolbutamide	Tolbutamide The serum concentration of Tolbutamide can be increased when it is combined with Selpercatinib.
Hydrochlorothiazide	Hydrochlorothiazide Selpercatinib may decrease the antihypertensive activities of Hydrochlorothiazide.
Propranolol (Cardiovascular)	Propranolol (Cardiovascular) Selpercatinib may decrease the antihypertensive activities of Propranolol.
Minoxidil	Minoxidil Selpercatinib may decrease the antihypertensive activities of Minoxidil.
Pseudoephedrine	Pseudoephedrine The risk or severity of hypertension can be increased when Pseudoephedrine is combined with Selpercatinib.
Nortriptyline	Nortriptyline The risk or severity of hypertension can be increased when Nortriptyline is combined with Selpercatinib.
Nadolol	Nadolol The excretion of Nadolol can be decreased when combined with Selpercatinib.
Fluorouracil Injection	Fluorouracil Injection The serum concentration of Fluorouracil can be increased when it is combined with Selpercatinib.
Colchicine	Colchicine The serum concentration of Selpercatinib can be decreased when it is combined with Colchicine.
Cephalexin	Cephalexin The excretion of Cephalexin can be decreased when combined with Selpercatinib.
Calcitonin Salmon Injection	Calcitonin Salmon Injection The therapeutic efficacy of Salmon calcitonin can be decreased when used in combination with Selpercatinib.
Ketoconazole	Ketoconazole The serum concentration of Selpercatinib can be increased when it is combined with Ketoconazole.
Captopril	Captopril Selpercatinib may decrease the antihypertensive activities of Captopril.
Isoxsuprine	Isoxsuprine The risk or severity of hypertension can be increased when Isoxsuprine is combined with Selpercatinib.
Vinblastine	Vinblastine The serum concentration of Selpercatinib can be decreased when it is combined with Vinblastine.
Metoprolol	Metoprolol Selpercatinib may decrease the antihypertensive activities of Metoprolol.
Hydroxyzine	Hydroxyzine The risk or severity of QTc prolongation can be increased when Selpercatinib is combined with Hydroxyzine.
Aspirin	Aspirin The risk or severity of hypertension can be increased when Acetylsalicylic acid is combined with Selpercatinib.
Salsalate	Salsalate The risk or severity of hypertension can be increased when Salsalate is combined with Selpercatinib.
Diltiazem	Diltiazem The serum concentration of Diltiazem can be increased when it is combined with Selpercatinib.
Nifedipine	Nifedipine The serum concentration of Selpercatinib can be decreased when it is combined with Nifedipine.
Timolol	Timolol Selpercatinib may decrease the antihypertensive activities of Timolol.
Verapamil	Verapamil The serum concentration of Verapamil can be increased when it is combined with Selpercatinib.
Atenolol	Atenolol Selpercatinib may decrease the antihypertensive activities of Atenolol.
Pindolol	Pindolol Selpercatinib may decrease the antihypertensive activities of Pindolol.
Diflunisal	Diflunisal The risk or severity of hypertension can be increased when Diflunisal is combined with Selpercatinib.
Piroxicam	Piroxicam The serum concentration of Selpercatinib can be increased when it is combined with Piroxicam.
Etoposide	Etoposide The serum concentration of Selpercatinib can be decreased when it is combined with Etoposide.
Indapamide	Indapamide Selpercatinib may decrease the antihypertensive activities of Indapamide.
Dicloxacillin	Dicloxacillin The serum concentration of Selpercatinib can be decreased when it is combined with Dicloxacillin.
Nafcillin Injection	Nafcillin Injection The serum concentration of Selpercatinib can be decreased when it is combined with Nafcillin.
Labetalol	Labetalol Selpercatinib may decrease the antihypertensive activities of Labetalol.
Guanabenz	Guanabenz Selpercatinib may decrease the antihypertensive activities of Guanabenz.
Ketoprofen	Ketoprofen The risk or severity of hypertension can be increased when Ketoprofen is combined with Selpercatinib.
Enalapril	Enalapril Selpercatinib may decrease the antihypertensive activities of Enalapril.
Flurbiprofen	Flurbiprofen The risk or severity of hypertension can be increased when Flurbiprofen is combined with Selpercatinib.
Amiodarone	Amiodarone The serum concentration of Amiodarone can be increased when it is combined with Selpercatinib.
Buspirone	Buspirone The risk or severity of hypertension can be increased when Buspirone is combined with Selpercatinib.
Lovastatin	Lovastatin The serum concentration of Lovastatin can be increased when it is combined with Selpercatinib.
Ciprofloxacin	Ciprofloxacin The serum concentration of Ciprofloxacin can be increased when it is combined with Selpercatinib.
Mesalamine	Mesalamine The risk or severity of hypertension can be increased when Mesalazine is combined with Selpercatinib.
Diclofenac	Diclofenac The serum concentration of Selpercatinib can be increased when it is combined with Diclofenac.
Oxiconazole	Oxiconazole The serum concentration of Selpercatinib can be decreased when it is combined with Oxiconazole.
Fluoxetine	Fluoxetine The risk or severity of QTc prolongation can be increased when Fluoxetine is combined with Selpercatinib.
Nimodipine	Nimodipine Selpercatinib may decrease the antihypertensive activities of Nimodipine.
Clozapine	Clozapine The serum concentration of Selpercatinib can be decreased when it is combined with Clozapine.
Clarithromycin	Clarithromycin The serum concentration of Selpercatinib can be increased when it is combined with Clarithromycin.
Benazepril	Benazepril Selpercatinib may decrease the antihypertensive activities of Benazepril.
Etodolac	Etodolac The risk or severity of hypertension can be increased when Etodolac is combined with Selpercatinib.
Felodipine	Felodipine Selpercatinib may decrease the antihypertensive activities of Felodipine.
Fosinopril	Fosinopril Selpercatinib may decrease the antihypertensive activities of Fosinopril.
Nabumetone	Nabumetone The risk or severity of hypertension can be increased when Nabumetone is combined with Selpercatinib.
Quinapril	Quinapril Selpercatinib may decrease the antihypertensive activities of Quinapril.
Ramipril	Ramipril Selpercatinib may decrease the antihypertensive activities of Ramipril.
Simvastatin	Simvastatin The serum concentration of Simvastatin can be increased when it is combined with Selpercatinib.
Epoetin Alfa, Injection	Epoetin Alfa, Injection The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Selpercatinib.
Amlodipine	Amlodipine Selpercatinib may decrease the antihypertensive activities of Amlodipine.
Itraconazole	Itraconazole The serum concentration of Selpercatinib can be increased when it is combined with Itraconazole.
Lisinopril	Lisinopril Selpercatinib may decrease the antihypertensive activities of Lisinopril.
Oxaprozin	Oxaprozin The risk or severity of hypertension can be increased when Oxaprozin is combined with Selpercatinib.
Rifabutin	Rifabutin The serum concentration of Selpercatinib can be decreased when it is combined with Rifabutin.
Bisoprolol	Bisoprolol Selpercatinib may decrease the antihypertensive activities of Bisoprolol.
Doxazosin	Doxazosin Selpercatinib may decrease the antihypertensive activities of Doxazosin.
Terazosin	Terazosin Selpercatinib may decrease the antihypertensive activities of Terazosin.
Isradipine	Isradipine Selpercatinib may decrease the antihypertensive activities of Isradipine.
Omeprazole	Omeprazole The serum concentration of Omeprazole can be decreased when it is combined with Selpercatinib.
Cisapride	Cisapride The serum concentration of Cisapride can be increased when it is combined with Selpercatinib.
Fluvastatin	Fluvastatin The serum concentration of Fluvastatin can be increased when it is combined with Selpercatinib.
Nizatidine	Nizatidine The serum concentration of Selpercatinib can be decreased when it is combined with Nizatidine.
Fluvoxamine	Fluvoxamine The serum concentration of Selpercatinib can be increased when it is combined with Fluvoxamine.
Nefazodone	Nefazodone The serum concentration of Selpercatinib can be increased when it is combined with Nefazodone.
Losartan	Losartan Selpercatinib may decrease the antihypertensive activities of Losartan.
Moexipril	Moexipril Selpercatinib may decrease the antihypertensive activities of Moexipril.
Lansoprazole	Lansoprazole The serum concentration of Lansoprazole can be decreased when it is combined with Selpercatinib.
Ifosfamide Injection	Ifosfamide Injection The serum concentration of Ifosfamide can be decreased when it is combined with Selpercatinib.
Nicardipine	Nicardipine The serum concentration of Nicardipine can be increased when it is combined with Selpercatinib.
Metformin	Metformin The excretion of Metformin can be decreased when combined with Selpercatinib.
Nisoldipine	Nisoldipine Selpercatinib may decrease the antihypertensive activities of Nisoldipine.
Anastrozole	Anastrozole The serum concentration of Anastrozole can be increased when it is combined with Selpercatinib.
Indinavir	Indinavir The serum concentration of Selpercatinib can be increased when it is combined with Indinavir.
Ritonavir	Ritonavir The serum concentration of Selpercatinib can be increased when it is combined with Ritonavir.
Clomipramine	Clomipramine The risk or severity of hypertension can be increased when Clomipramine is combined with Selpercatinib.
Zafirlukast	Zafirlukast The serum concentration of Zafirlukast can be increased when it is combined with Selpercatinib.
Mirtazapine	Mirtazapine The risk or severity of hypertension can be increased when Mirtazapine is combined with Selpercatinib.
Trandolapril	Trandolapril Selpercatinib may decrease the antihypertensive activities of Trandolapril.
Topiramate	Topiramate The serum concentration of Selpercatinib can be decreased when it is combined with Topiramate.
Valsartan	Valsartan Selpercatinib may decrease the antihypertensive activities of Valsartan.
Nelfinavir	Nelfinavir The serum concentration of Selpercatinib can be increased when it is combined with Nelfinavir.
Carvedilol	Carvedilol Selpercatinib may decrease the antihypertensive activities of Carvedilol.
Selegiline	Selegiline The serum concentration of Selpercatinib can be increased when it is combined with Selegiline.
Propafenone	Propafenone The risk or severity of hypertension can be increased when Propafenone is combined with Selpercatinib.
Irbesartan	Irbesartan The serum concentration of Irbesartan can be increased when it is combined with Selpercatinib.
Finasteride	Finasteride The risk or severity of hypertension can be increased when Finasteride is combined with Selpercatinib.
Quetiapine	Quetiapine The risk or severity of hypertension can be increased when Quetiapine is combined with Selpercatinib.
Paroxetine	Paroxetine The serum concentration of Selpercatinib can be increased when it is combined with Paroxetine.
Efavirenz	Efavirenz The serum concentration of Selpercatinib can be decreased when it is combined with Efavirenz.
Pioglitazone	Pioglitazone The serum concentration of Pioglitazone can be increased when it is combined with Selpercatinib.
Celecoxib	Celecoxib The serum concentration of Selpercatinib can be increased when it is combined with Celecoxib.
Rosiglitazone	Rosiglitazone The serum concentration of Rosiglitazone can be increased when it is combined with Selpercatinib.
Thalidomide	Thalidomide The serum concentration of Selpercatinib can be decreased when it is combined with Thalidomide.
Aluminum Hydroxide	Aluminum Hydroxide The serum concentration of Selpercatinib can be decreased when it is combined with Aluminum hydroxide.
Balsalazide	Balsalazide The risk or severity of hypertension can be increased when Balsalazide is combined with Selpercatinib.
Rabeprazole	Rabeprazole The serum concentration of Selpercatinib can be decreased when it is combined with Rabeprazole.
Terbinafine	Terbinafine The serum concentration of Terbinafine can be decreased when it is combined with Selpercatinib.