Trabectedin Injection

Generic name: Pronounced as (tra bek' te din)
Brand names
  • Yondelis®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 12/15/2015

Trabectedin injection is used to treat liposarcoma (a cancer that begins in fat cells) or leiomyosarcoma (a cancer that begins in smooth muscle tissue) that has spread to other parts of the body and cannot be treated with surgery in people who have already been treated with certain chemotherapy medications. Trabectedin is in a class of medications called alkylating agents. It works by slowing or stopping the growth of cancer cells in your body.

Trabectedin injection comes as a powder to be mixed with liquid to be injected over 24 hours intravenously (into a vein) by a doctor or nurse in a medical facility. It is usually given once every 3 weeks for as long as your doctor recommends that you receive treatment.

Your doctor may delay or stop your treatment with trabectedin injection depending on your response to the medication and any side effects that you experience. Talk to your doctor about how you are feeling during your treatment.

Your doctor will probably prescribe a medication for you to take before you receive each dose of trabectedin to help prevent side effects.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before receiving trabectedin injection,

  • tell your doctor and pharmacist if you are allergic to trabectedin injection, any other medications, or any of the ingredients in trabectedin injection. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: certain antifungals such as itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), and voriconazole (Vfend); boceprevir (Victrelis); clarithromycin (Biaxin, in Prevpac); conivaptan (Vaprisol); certain medications for HIV including indinavir (Crixivan), lopinavir (in Kaletra), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra, in Technivie, others), and saquinavir (Invirase); nefazodone; phenobarbital; rifampin (Rifadin, Rimactane, in Rifamate, in Rifater); telaprevir (Incivek; no longer available in the U.S.); and telithromycin (Ketek). Your doctor may need to change the doses or timing of your medications or monitor you carefully for side effects. Many other medications may also interact with trabectedin, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

  • tell your doctor what herbal products you are taking, especially St. John's wort.

  • tell your doctor if you have or have ever had liver or kidney disease.

  • you should know that trabectedin injection may cause infertility (difficulty becoming pregnant); however, you should not assume that you cannot get pregnant. Tell your doctor if you are pregnant or plan to become pregnant. If you are female, you should use birth control to prevent pregnancy during your treatment with trabectedin and for at least 2 months after you stop using the medication. If you are male, you and your female partner should use birth control during your treatment with trabectedin and continue for 5 months after you stop receiving trabectedin injection. If you become pregnant while using trabectedin injection, call your doctor. Trabectedin injection may harm the fetus and increase the risk of a pregnancy loss.

  • tell your doctor if you are breast-feeding. Do not breastfeed while you are receiving trabectedin injection.

Do not eat grapefruit or drink grapefruit juice while receiving this medication.

  • Trabectedin injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • tiredness

    • headache

    • joint pain

    • constipation

    • diarrhea

    • decreased appetite

    • difficulty sleeping or falling asleep

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

    • redness, swelling, itchiness and discomfort or leakage at the injection site

    • swelling of the face

    • difficulty breathing

    • chest tightness

    • wheezing

    • rash

    • severe dizziness or lightheadedness

    • fever

    • unusual bruising or bleeding

    • paleness

    • yellowing of skin and eyes

    • pain in the upper stomach area

    • nausea

    • vomiting

    • difficulty concentrating

    • confusion

    • chest pain

    • shortness of breath

    • swelling of your legs, ankles, or feet

    • muscle pain or weakness

  • Trabectedin injection may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to trabectedin.

Ask your pharmacist any questions you have about trabectedin injection.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Montelukast Montelukast The metabolism of Trabectedin can be decreased when combined with Montelukast.
Leflunomide Leflunomide The risk or severity of adverse effects can be increased when Trabectedin is combined with Leflunomide.
Delavirdine Delavirdine The metabolism of Trabectedin can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Trabectedin can be decreased when combined with Nevirapine.
Atorvastatin Atorvastatin The risk or severity of myopathy and rhabdomyolysis can be increased when Atorvastatin is combined with Trabectedin.
Dolasetron Dolasetron The metabolism of Trabectedin can be decreased when combined with Dolasetron.
Alendronate Alendronate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Alendronic acid is combined with Trabectedin.
Aminophylline Aminophylline The metabolism of Trabectedin can be decreased when combined with Aminophylline.
Anagrelide Anagrelide The risk or severity of bleeding can be increased when Anagrelide is combined with Trabectedin.
Candesartan Candesartan The metabolism of Trabectedin can be decreased when combined with Candesartan.
Cilostazol Cilostazol The metabolism of Trabectedin can be decreased when combined with Cilostazol.
Clopidogrel Clopidogrel The metabolism of Trabectedin can be decreased when combined with Clopidogrel.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The metabolism of Trabectedin can be decreased when combined with Erythromycin.
Fenofibrate Fenofibrate The metabolism of Trabectedin can be decreased when combined with Fenofibrate.
Methylergonovine Methylergonovine The metabolism of Trabectedin can be decreased when combined with Methylergometrine.
Mycophenolate Mycophenolate The risk or severity of adverse effects can be increased when Mycophenolic acid is combined with Trabectedin.
Nafarelin Nafarelin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Nafarelin is combined with Trabectedin.
Penbutolol Penbutolol The metabolism of Trabectedin can be decreased when combined with Acebutolol.
Prednisone Prednisone The risk or severity of adverse effects can be increased when Prednisone is combined with Trabectedin.
Ranitidine Ranitidine The metabolism of Trabectedin can be decreased when combined with Ranitidine.
Tacrolimus Tacrolimus Tacrolimus may increase the immunosuppressive activities of Trabectedin.
Triamcinolone Triamcinolone The metabolism of Trabectedin can be increased when combined with Triamcinolone.
Doxycycline Injection Doxycycline Injection The metabolism of Trabectedin can be decreased when combined with Doxycycline.
Fluconazole Injection Fluconazole Injection The metabolism of Trabectedin can be decreased when combined with Fluconazole.
Hydromorphone Injection Hydromorphone Injection The metabolism of Trabectedin can be decreased when combined with Hydromorphone.
Interferon Beta-1b Injection Interferon Beta-1b Injection The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Trabectedin.
Interferon Gamma-1b Injection Interferon Gamma-1b Injection The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Trabectedin.
Meperidine Injection Meperidine Injection The metabolism of Trabectedin can be increased when combined with Meperidine.
Methylprednisolone Injection Methylprednisolone Injection The metabolism of Trabectedin can be increased when combined with Methylprednisolone.
Metoclopramide Injection Metoclopramide Injection The metabolism of Trabectedin can be decreased when combined with Metoclopramide.
Metronidazole Injection Metronidazole Injection The metabolism of Trabectedin can be decreased when combined with Metronidazole.
Pamidronate Injection Pamidronate Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pamidronic acid is combined with Trabectedin.
Zidovudine Injection Zidovudine Injection The metabolism of Trabectedin can be decreased when combined with Zidovudine.
Altretamine Altretamine The metabolism of Trabectedin can be decreased when combined with Amphetamine.
Cyclosporine Cyclosporine Trabectedin may increase the immunosuppressive activities of Cyclosporine.
Ondansetron Ondansetron The metabolism of Trabectedin can be decreased when combined with Ondansetron.
Enoxaparin Injection Enoxaparin Injection The risk or severity of bleeding can be increased when Enoxaparin is combined with Trabectedin.
Torsemide Torsemide The metabolism of Trabectedin can be decreased when combined with Torasemide.
Olanzapine Olanzapine The metabolism of Trabectedin can be decreased when combined with Olanzapine.
Alosetron Alosetron The metabolism of Trabectedin can be decreased when combined with Alosetron.
Entacapone Entacapone The metabolism of Trabectedin can be decreased when combined with Entacapone.
Eprosartan Eprosartan The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Eprosartan is combined with Trabectedin.
Hydroxychloroquine Hydroxychloroquine The metabolism of Trabectedin can be decreased when combined with Hydroxychloroquine.
Meloxicam Meloxicam The metabolism of Trabectedin can be decreased when combined with Meloxicam.
Orlistat Orlistat The metabolism of Trabectedin can be increased when combined with Orlistat.
Oxcarbazepine Oxcarbazepine The metabolism of Trabectedin can be increased when combined with Oxcarbazepine.
Pantoprazole Pantoprazole The metabolism of Trabectedin can be decreased when combined with Pantoprazole.
Risedronate Risedronate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Risedronic acid is combined with Trabectedin.
Telmisartan Telmisartan The metabolism of Trabectedin can be decreased when combined with Telmisartan.
Temozolomide Temozolomide The risk or severity of adverse effects can be increased when Temozolomide is combined with Trabectedin.
Anakinra Anakinra The metabolism of Trabectedin can be increased when combined with Anakinra.
Linezolid Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Trabectedin.
Pentosan Polysulfate Pentosan Polysulfate The risk or severity of bleeding can be increased when Pentosan polysulfate is combined with Trabectedin.
Trimipramine Trimipramine The metabolism of Trabectedin can be decreased when combined with Trimipramine.
Etanercept Injection Etanercept Injection The metabolism of Trabectedin can be increased when combined with Etanercept.
Modafinil Modafinil The metabolism of Trabectedin can be increased when combined with Modafinil.
Tenofovir Tenofovir The metabolism of Trabectedin can be decreased when combined with Tenofovir.
Sirolimus Sirolimus The risk or severity of adverse effects can be increased when Sirolimus is combined with Trabectedin.
Epinephrine Injection Epinephrine Injection The metabolism of Trabectedin can be decreased when combined with Epinephrine.
Epirubicin Epirubicin The risk or severity of adverse effects can be increased when Epirubicin is combined with Trabectedin.
Escitalopram Escitalopram The serum concentration of Trabectedin can be increased when it is combined with Escitalopram.
Zonisamide Zonisamide The metabolism of Trabectedin can be decreased when combined with Zonisamide.
Adalimumab Injection Adalimumab Injection The metabolism of Trabectedin can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The metabolism of Trabectedin can be decreased when combined with Aripiprazole.
Atomoxetine Atomoxetine The metabolism of Trabectedin can be decreased when combined with Atomoxetine.
Glatiramer Injection Glatiramer Injection The risk or severity of adverse effects can be increased when Trabectedin is combined with Glatiramer.
Atazanavir Atazanavir The metabolism of Trabectedin can be decreased when combined with Atazanavir.
Almotriptan Almotriptan The metabolism of Trabectedin can be decreased when combined with Almotriptan.
Eletriptan Eletriptan The metabolism of Trabectedin can be decreased when combined with Eletriptan.
Mefloquine Mefloquine The metabolism of Trabectedin can be decreased when combined with Mefloquine.
Rosuvastatin Rosuvastatin The risk or severity of myopathy and rhabdomyolysis can be increased when Rosuvastatin is combined with Trabectedin.
Aprepitant Aprepitant The metabolism of Trabectedin can be decreased when combined with Aprepitant.
Memantine Memantine The metabolism of Trabectedin can be decreased when combined with Memantine.
Tegaserod Tegaserod The metabolism of Trabectedin can be decreased when combined with Tegaserod.
Progesterone Progesterone The metabolism of Trabectedin can be increased when combined with Progesterone.
Darbepoetin Alfa Injection Darbepoetin Alfa Injection The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Trabectedin.
Infliximab Injection Infliximab Injection The metabolism of Trabectedin can be increased when combined with Infliximab.
Oxandrolone Oxandrolone The metabolism of Trabectedin can be decreased when combined with Oxandrolone.
Protriptyline Protriptyline The metabolism of Trabectedin can be decreased when combined with Protriptyline.
Rifaximin Rifaximin The metabolism of Trabectedin can be increased when combined with Rifaximin.
Duloxetine Duloxetine The metabolism of Trabectedin can be decreased when combined with Duloxetine.
Norethindrone Norethindrone The metabolism of Trabectedin can be increased when combined with Norethisterone.
Trospium Trospium The metabolism of Trabectedin can be decreased when combined with Trospium.
Bosentan Bosentan The metabolism of Trabectedin can be increased when combined with Bosentan.
Cinacalcet Cinacalcet The metabolism of Trabectedin can be decreased when combined with Cinacalcet.
Natalizumab Injection Natalizumab Injection The risk or severity of adverse effects can be increased when Trabectedin is combined with Natalizumab.
Erlotinib Erlotinib The metabolism of Trabectedin can be decreased when combined with Erlotinib.
Ganciclovir Ganciclovir The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Ganciclovir is combined with Trabectedin.
Palifermin Palifermin The therapeutic efficacy of Palifermin can be decreased when used in combination with Trabectedin.
Solifenacin Solifenacin The metabolism of Trabectedin can be decreased when combined with Solifenacin.
Voriconazole Voriconazole The metabolism of Trabectedin can be decreased when combined with Voriconazole.
Dextroamphetamine Dextroamphetamine The metabolism of Trabectedin can be decreased when combined with Amphetamine.
Peginterferon Alfa-2a Injection Peginterferon Alfa-2a Injection The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Trabectedin.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The metabolism of Trabectedin can be decreased when combined with Peginterferon alfa-2b.
Ibandronate Ibandronate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Ibandronate is combined with Trabectedin.
Ramelteon Ramelteon The metabolism of Trabectedin can be decreased when combined with Ramelteon.
Darifenacin Darifenacin The metabolism of Darifenacin can be decreased when combined with Trabectedin.
Deferasirox Deferasirox The metabolism of Trabectedin can be increased when combined with Deferasirox.
Tipranavir Tipranavir The metabolism of Tipranavir can be decreased when combined with Trabectedin.
Felbamate Felbamate The metabolism of Trabectedin can be increased when combined with Felbamate.
Ranolazine Ranolazine The serum concentration of Trabectedin can be increased when it is combined with Ranolazine.
Abatacept Injection Abatacept Injection The metabolism of Trabectedin can be increased when combined with Abatacept.
Imatinib Imatinib The metabolism of Trabectedin can be decreased when combined with Imatinib.
Bevacizumab Injection Bevacizumab Injection The risk or severity of adverse effects can be increased when Bevacizumab is combined with Trabectedin.
Gefitinib Gefitinib The metabolism of Trabectedin can be decreased when combined with Gefitinib.
Paliperidone Paliperidone The metabolism of Trabectedin can be decreased when combined with Paliperidone.
Bortezomib Bortezomib The metabolism of Trabectedin can be decreased when combined with Bortezomib.
Clofarabine Injection Clofarabine Injection The risk or severity of adverse effects can be increased when Clofarabine is combined with Trabectedin.
Hepatitis B Vaccine Hepatitis B Vaccine The therapeutic efficacy of Hepatitis B Vaccine (Recombinant) can be decreased when used in combination with Trabectedin.
Influenza Vaccine, Inactivated or Recombinant Influenza Vaccine, Inactivated or Recombinant The therapeutic efficacy of Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Trabectedin.
Influenza Vaccine, Live Intranasal Influenza Vaccine, Live Intranasal The risk or severity of infection can be increased when Typhoid Vaccine Live is combined with Trabectedin.
Live Shingles (Zoster) Vaccine (ZVL) Live Shingles (Zoster) Vaccine (ZVL) The risk or severity of infection can be increased when Varicella Zoster Vaccine (Live/attenuated) is combined with Trabectedin.
Oxaliplatin Injection Oxaliplatin Injection The risk or severity of adverse effects can be increased when Oxaliplatin is combined with Trabectedin.
Posaconazole Posaconazole The metabolism of Trabectedin can be decreased when combined with Posaconazole.
Primaquine Primaquine The metabolism of Trabectedin can be decreased when combined with Primaquine.
Rituximab Injection Rituximab Injection The risk or severity of adverse effects can be increased when Rituximab is combined with Trabectedin.
Darunavir Darunavir The metabolism of Darunavir can be decreased when combined with Trabectedin.
Pemetrexed Injection Pemetrexed Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Trabectedin.
Lisdexamfetamine Lisdexamfetamine The metabolism of Trabectedin can be decreased when combined with Lisdexamfetamine.
Nabilone Nabilone The metabolism of Trabectedin can be decreased when combined with Nabilone.
Vorinostat Vorinostat The risk or severity of adverse effects can be increased when Vorinostat is combined with Trabectedin.
Sorafenib Sorafenib The metabolism of Trabectedin can be decreased when combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Trabectedin can be decreased when combined with Sunitinib.
Dronabinol Dronabinol The metabolism of Trabectedin can be decreased when combined with Dronabinol.
Lapatinib Lapatinib The metabolism of Trabectedin can be decreased when combined with Lapatinib.
Dasatinib Dasatinib The metabolism of Trabectedin can be decreased when combined with Dasatinib.
Mexiletine Mexiletine The metabolism of Trabectedin can be decreased when combined with Mexiletine.
Armodafinil Armodafinil The metabolism of Trabectedin can be increased when combined with Armodafinil.
Azacitidine Injection Azacitidine Injection The risk or severity of adverse effects can be increased when Azacitidine is combined with Trabectedin.
Ivermectin Ivermectin The metabolism of Trabectedin can be increased when combined with Ivermectin.
Temsirolimus Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Trabectedin.
Nelarabine Injection Nelarabine Injection The risk or severity of adverse effects can be increased when Nelarabine is combined with Trabectedin.
Lenalidomide Lenalidomide The risk or severity of adverse effects can be increased when Lenalidomide is combined with Trabectedin.
Nilotinib Nilotinib The metabolism of Trabectedin can be decreased when combined with Nilotinib.
Raltegravir Raltegravir The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Trabectedin is combined with Raltegravir.
Bexarotene Bexarotene The metabolism of Trabectedin can be increased when combined with Bexarotene.
Budesonide Budesonide The metabolism of Trabectedin can be increased when combined with Budesonide.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Trabectedin can be decreased when combined with Chloramphenicol.
Decitabine Injection Decitabine Injection The risk or severity of adverse effects can be increased when Decitabine is combined with Trabectedin.
Etravirine Etravirine The metabolism of Trabectedin can be increased when combined with Etravirine.
Arsenic Trioxide Injection Arsenic Trioxide Injection The risk or severity of adverse effects can be increased when Arsenic trioxide is combined with Trabectedin.
Mitoxantrone Injection Mitoxantrone Injection The metabolism of Trabectedin can be decreased when combined with Mitoxantrone.
Desvenlafaxine Desvenlafaxine The metabolism of Trabectedin can be decreased when combined with Desvenlafaxine.
Cevimeline Cevimeline The metabolism of Trabectedin can be decreased when combined with Cevimeline.
Nebivolol Nebivolol The metabolism of Trabectedin can be decreased when combined with Nebivolol.
Tretinoin Tretinoin The metabolism of Trabectedin can be decreased when combined with Tretinoin.
Bendamustine Injection Bendamustine Injection The risk or severity of adverse effects can be increased when Trabectedin is combined with Bendamustine.
Pilocarpine Pilocarpine The metabolism of Trabectedin can be decreased when combined with Pilocarpine.
Flecainide Flecainide The metabolism of Flecainide can be decreased when combined with Trabectedin.
Certolizumab Injection Certolizumab Injection The metabolism of Trabectedin can be increased when combined with Certolizumab pegol.
Ixabepilone Injection Ixabepilone Injection The risk or severity of adverse effects can be increased when Ixabepilone is combined with Trabectedin.
Irinotecan Injection Irinotecan Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Trabectedin.
Daptomycin Injection Daptomycin Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Trabectedin.
Estramustine Estramustine The risk or severity of adverse effects can be increased when Estramustine is combined with Trabectedin.
Mitotane Mitotane The metabolism of Trabectedin can be increased when combined with Mitotane.
Alemtuzumab Injection (Chronic Lymphocytic Leukemia) Alemtuzumab Injection (Chronic Lymphocytic Leukemia) The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Trabectedin.
Rufinamide Rufinamide The metabolism of Trabectedin can be increased when combined with Rufinamide.
Midazolam Midazolam The metabolism of Trabectedin can be decreased when combined with Midazolam.
Naltrexone Injection Naltrexone Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Trabectedin.
Dexrazoxane Injection Dexrazoxane Injection The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Trabectedin.
Ibritumomab Injection Ibritumomab Injection The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Trabectedin.
Milnacipran Milnacipran The metabolism of Trabectedin can be decreased when combined with Milnacipran.
Dexlansoprazole Dexlansoprazole The metabolism of Trabectedin can be decreased when combined with Dexlansoprazole.
Fesoterodine Fesoterodine The metabolism of Fesoterodine can be decreased when combined with Trabectedin.
Betaxolol Betaxolol The metabolism of Trabectedin can be decreased when combined with Betaxolol.
Iloperidone Iloperidone The metabolism of Trabectedin can be decreased when combined with Iloperidone.
Prasugrel Prasugrel The metabolism of Trabectedin can be decreased when combined with Prasugrel.
Lacosamide Lacosamide The metabolism of Lacosamide can be decreased when combined with Trabectedin.
Everolimus Everolimus The metabolism of Trabectedin can be decreased when combined with Everolimus.
Dronedarone Dronedarone The metabolism of Dronedarone can be decreased when combined with Trabectedin.
Pralatrexate Injection Pralatrexate Injection The risk or severity of adverse effects can be increased when Trabectedin is combined with Pralatrexate.
Palonosetron Injection Palonosetron Injection The metabolism of Trabectedin can be decreased when combined with Palonosetron.
Tapentadol Tapentadol The metabolism of Trabectedin can be decreased when combined with Tapentadol.
Topotecan Topotecan The metabolism of Trabectedin can be increased when combined with Topotecan.
Golimumab Injection Golimumab Injection The metabolism of Trabectedin can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Pazopanib can be decreased when combined with Trabectedin.
Pitavastatin Pitavastatin The risk or severity of myopathy and rhabdomyolysis can be increased when Pitavastatin is combined with Trabectedin.
Albendazole Albendazole The metabolism of Trabectedin can be decreased when combined with Albendazole.
Oxymorphone Oxymorphone The metabolism of Trabectedin can be decreased when combined with Oxymorphone.
Denosumab Injection Denosumab Injection The risk or severity of adverse effects can be increased when Denosumab is combined with Trabectedin.
Dabigatran Dabigatran The risk or severity of bleeding can be increased when Dabigatran is combined with Trabectedin.
Tocilizumab Injection Tocilizumab Injection The metabolism of Trabectedin can be increased when combined with Tocilizumab.
Fingolimod Fingolimod Trabectedin may increase the immunosuppressive activities of Fingolimod.
Eribulin Injection Eribulin Injection The risk or severity of adverse effects can be increased when Trabectedin is combined with Eribulin.
Cabazitaxel Injection Cabazitaxel Injection The risk or severity of adverse effects can be increased when Trabectedin is combined with Cabazitaxel.
Acetaminophen Injection Acetaminophen Injection The metabolism of Trabectedin can be increased when combined with Acetaminophen.
Vilazodone Vilazodone The metabolism of Trabectedin can be decreased when combined with Vilazodone.
Denileukin Diftitox Injection Denileukin Diftitox Injection The metabolism of Trabectedin can be decreased when combined with Aldesleukin.
Sipuleucel-T Injection Sipuleucel-T Injection The therapeutic efficacy of Sipuleucel-T can be decreased when used in combination with Trabectedin.
Belimumab Injection Belimumab Injection The risk or severity of adverse effects can be increased when Trabectedin is combined with Belimumab.
Busulfan Injection Busulfan Injection The risk or severity of adverse effects can be increased when Busulfan is combined with Trabectedin.
Roflumilast Roflumilast Roflumilast may increase the immunosuppressive activities of Trabectedin.
Linagliptin Linagliptin The metabolism of Trabectedin can be decreased when combined with Linagliptin.
Rilpivirine Rilpivirine The metabolism of Trabectedin can be decreased when combined with Rilpivirine.
Telaprevir Telaprevir The metabolism of Trabectedin can be decreased when combined with Glecaprevir.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Trabectedin can be increased when combined with Cyclophosphamide.
Abiraterone Abiraterone The metabolism of Trabectedin can be decreased when combined with Abiraterone.
Rivaroxaban Rivaroxaban The risk or severity of bleeding can be increased when Rivaroxaban is combined with Trabectedin.
Ticagrelor Ticagrelor The metabolism of Trabectedin can be decreased when combined with Ticagrelor.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Brentuximab vedotin can be decreased when combined with Trabectedin.
Ruxolitinib Ruxolitinib The risk or severity of adverse effects can be increased when Trabectedin is combined with Ruxolitinib.
Clobazam Clobazam The metabolism of Trabectedin can be decreased when combined with Clobazam.
Vemurafenib Vemurafenib The metabolism of Trabectedin can be increased when combined with Vemurafenib.
Vismodegib Vismodegib The metabolism of Trabectedin can be decreased when combined with Vismodegib.
Belatacept Injection Belatacept Injection The risk or severity of adverse effects can be increased when Trabectedin is combined with Belatacept.
Ivacaftor Ivacaftor The metabolism of Trabectedin can be decreased when combined with Ivacaftor.
Basiliximab Injection Basiliximab Injection The risk or severity of adverse effects can be increased when Basiliximab is combined with Trabectedin.
Axitinib Axitinib The metabolism of Axitinib can be decreased when combined with Trabectedin.
Crizotinib Crizotinib The metabolism of Trabectedin can be decreased when combined with Crizotinib.
Melphalan Injection Melphalan Injection The risk or severity of adverse effects can be increased when Melphalan is combined with Trabectedin.
Cabergoline Cabergoline The metabolism of Trabectedin can be decreased when combined with Cabergoline.
Naloxone Injection Naloxone Injection The metabolism of Trabectedin can be decreased when combined with Naloxone.
Eculizumab Injection Eculizumab Injection The risk or severity of adverse effects can be increased when Eculizumab is combined with Trabectedin.
Fondaparinux Injection Fondaparinux Injection The risk or severity of bleeding can be increased when Fondaparinux is combined with Trabectedin.
Carfilzomib Injection Carfilzomib Injection The risk or severity of adverse effects can be increased when Trabectedin is combined with Carfilzomib.
Iloprost Iloprost The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Iloprost is combined with Trabectedin.
Enzalutamide Enzalutamide The metabolism of Trabectedin can be increased when combined with Enzalutamide.
Mirabegron Mirabegron The serum concentration of Mirabegron can be increased when it is combined with Trabectedin.
Regorafenib Regorafenib The metabolism of Trabectedin can be decreased when combined with Regorafenib.
Bosutinib Bosutinib The metabolism of Bosutinib can be decreased when combined with Trabectedin.
Corticotropin, Repository Injection Corticotropin, Repository Injection The metabolism of Trabectedin can be increased when combined with Corticotropin.
Teriflunomide Teriflunomide The risk or severity of adverse effects can be increased when Trabectedin is combined with Teriflunomide.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Trabectedin.
Icosapent Ethyl Icosapent Ethyl The risk or severity of bleeding can be increased when Icosapent ethyl is combined with Trabectedin.
Tofacitinib Tofacitinib Trabectedin may increase the immunosuppressive activities of Tofacitinib.
Alogliptin Alogliptin The metabolism of Alogliptin can be decreased when combined with Trabectedin.
Dimethyl Fumarate Dimethyl Fumarate The risk or severity of adverse effects can be increased when Trabectedin is combined with Dimethyl fumarate.
Ponatinib Ponatinib The metabolism of Ponatinib can be decreased when combined with Trabectedin.
Pomalidomide Pomalidomide The risk or severity of adverse effects can be increased when Trabectedin is combined with Pomalidomide.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be decreased when combined with Trabectedin.
Apixaban Apixaban The metabolism of Apixaban can be decreased when combined with Trabectedin.
Dabrafenib Dabrafenib The metabolism of Trabectedin can be increased when combined with Dabrafenib.
Ospemifene Ospemifene The metabolism of Trabectedin can be decreased when combined with Ospemifene.
Trametinib Trametinib The metabolism of Trabectedin can be increased when combined with Trametinib.
Levomilnacipran Levomilnacipran The metabolism of Levomilnacipran can be decreased when combined with Trabectedin.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Trabectedin.
Perampanel Perampanel The metabolism of Trabectedin can be increased when combined with Perampanel.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Trabectedin.
Lomitapide Lomitapide The metabolism of Trabectedin can be decreased when combined with Lomitapide.
Ketorolac Injection Ketorolac Injection The metabolism of Trabectedin can be decreased when combined with Ketorolac.
Obinutuzumab Injection Obinutuzumab Injection The risk or severity of adverse effects can be increased when Trabectedin is combined with Obinutuzumab.
Simeprevir Simeprevir The metabolism of Trabectedin can be decreased when combined with Simeprevir.
Dapagliflozin Dapagliflozin The metabolism of Dapagliflozin can be decreased when combined with Trabectedin.
Apremilast Apremilast The metabolism of Trabectedin can be increased when combined with Apremilast.
Ceritinib Ceritinib The metabolism of Trabectedin can be decreased when combined with Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Trabectedin can be increased when combined with Siltuximab.
Eslicarbazepine Eslicarbazepine The metabolism of Trabectedin can be increased when combined with Eslicarbazepine.
Vedolizumab Injection Vedolizumab Injection The risk or severity of adverse effects can be increased when Trabectedin is combined with Vedolizumab.
Belinostat Injection Belinostat Injection The risk or severity of adverse effects can be increased when Belinostat is combined with Trabectedin.
Idelalisib Idelalisib The risk or severity of adverse effects can be increased when Idelalisib is combined with Trabectedin.
Testosterone Injection Testosterone Injection The metabolism of Trabectedin can be increased when combined with Testosterone.
Oritavancin Injection Oritavancin Injection The metabolism of Trabectedin can be increased when combined with Oritavancin.
Vorapaxar Vorapaxar The metabolism of Trabectedin can be decreased when combined with Vorapaxar.
Hydrocodone Hydrocodone The metabolism of Trabectedin can be decreased when combined with Hydrocodone.
Suvorexant Suvorexant The metabolism of Trabectedin can be decreased when combined with Suvorexant.
Edoxaban Edoxaban The risk or severity of bleeding can be increased when Edoxaban is combined with Trabectedin.
Peginterferon Beta-1a Injection Peginterferon Beta-1a Injection The risk or severity of adverse effects can be increased when Trabectedin is combined with Peginterferon beta-1a.
Olaparib Olaparib The metabolism of Olaparib can be decreased when combined with Trabectedin.
Blinatumomab Injection Blinatumomab Injection The risk or severity of adverse effects can be increased when Trabectedin is combined with Blinatumomab.
Methamphetamine Methamphetamine The metabolism of Trabectedin can be decreased when combined with Metamfetamine.
Tasimelteon Tasimelteon The metabolism of Trabectedin can be decreased when combined with Tasimelteon.
Lanreotide Injection Lanreotide Injection The metabolism of Trabectedin can be decreased when combined with Lanreotide.
Pirfenidone Pirfenidone The risk or severity of adverse effects can be increased when Pirfenidone is combined with Trabectedin.
Nintedanib Nintedanib The metabolism of Trabectedin can be decreased when combined with Nintedanib.
Secukinumab Injection Secukinumab Injection The metabolism of Trabectedin can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The metabolism of Trabectedin can be decreased when combined with Risperidone.
Palbociclib Palbociclib The metabolism of Palbociclib can be decreased when combined with Trabectedin.
Lenvatinib Lenvatinib The metabolism of Trabectedin can be increased when combined with Lenvatinib.
Naloxegol Naloxegol The metabolism of Trabectedin can be decreased when combined with Naloxegol.
Panobinostat Panobinostat The metabolism of Panobinostat can be decreased when combined with Trabectedin.
Dinutuximab Injection Dinutuximab Injection The risk or severity of adverse effects can be increased when Trabectedin is combined with Dinutuximab.
Haloperidol Injection Haloperidol Injection The serum concentration of Trabectedin can be increased when it is combined with Haloperidol.
Isavuconazonium Injection Isavuconazonium Injection The metabolism of Trabectedin can be increased when combined with Isavuconazonium.
Rolapitant Rolapitant The metabolism of Trabectedin can be decreased when combined with Rolapitant.
Prednisolone Prednisolone The metabolism of Trabectedin can be increased when combined with Prednisolone.
Brexpiprazole Brexpiprazole The metabolism of Brexpiprazole can be decreased when combined with Trabectedin.
Ziprasidone Injection Ziprasidone Injection The metabolism of Trabectedin can be decreased when combined with Ziprasidone.
Cariprazine Cariprazine The metabolism of Cariprazine can be decreased when combined with Trabectedin.
Cobimetinib Cobimetinib The metabolism of Trabectedin can be decreased when combined with Cobimetinib.
Mepolizumab Injection Mepolizumab Injection The risk or severity of adverse effects can be increased when Trabectedin is combined with Mepolizumab.
Osimertinib Osimertinib The metabolism of Trabectedin can be increased when combined with Osimertinib.
Rifapentine Rifapentine The metabolism of Trabectedin can be increased when combined with Rifapentine.
Lesinurad Lesinurad The metabolism of Lesinurad can be increased when combined with Trabectedin.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The metabolism of Trabectedin can be decreased when combined with Amphotericin B.
Dexamethasone Injection Dexamethasone Injection The metabolism of Trabectedin can be increased when combined with Dexamethasone.
Defibrotide Injection Defibrotide Injection The risk or severity of bleeding can be increased when Defibrotide is combined with Trabectedin.
Ixekizumab Injection Ixekizumab Injection The risk or severity of adverse effects can be increased when Trabectedin is combined with Ixekizumab.
Brivaracetam Injection Brivaracetam Injection The metabolism of Brivaracetam can be decreased when combined with Trabectedin.
Venetoclax Venetoclax The metabolism of Trabectedin can be decreased when combined with Venetoclax.
Cobicistat Cobicistat The metabolism of Trabectedin can be decreased when combined with Cobicistat.
Diphenhydramine Injection Diphenhydramine Injection The metabolism of Trabectedin can be decreased when combined with Diphenhydramine.
Rucaparib Rucaparib The metabolism of Trabectedin can be decreased when combined with Rucaparib.
Ribociclib Ribociclib The metabolism of Trabectedin can be decreased when combined with Ribociclib.
Brodalumab Injection Brodalumab Injection The risk or severity of adverse effects can be increased when Trabectedin is combined with Brodalumab.
Brigatinib Brigatinib The metabolism of Trabectedin can be increased when combined with Brigatinib.
Doxepin (Insomnia) Doxepin (Insomnia) The metabolism of Trabectedin can be decreased when combined with Doxepin.
Deutetrabenazine Deutetrabenazine The metabolism of Deutetrabenazine can be decreased when combined with Trabectedin.
Valbenazine Valbenazine The metabolism of Valbenazine can be decreased when combined with Trabectedin.
Deflazacort Deflazacort The metabolism of Deflazacort can be increased when combined with Trabectedin.
Safinamide Safinamide The metabolism of Trabectedin can be decreased when combined with Safinamide.
Ocrelizumab Injection Ocrelizumab Injection Ocrelizumab may increase the immunosuppressive activities of Trabectedin.
Sarilumab Injection Sarilumab Injection The metabolism of Sarilumab can be increased when combined with Trabectedin.
Midostaurin Midostaurin The metabolism of Trabectedin can be decreased when combined with Midostaurin.
Guselkumab Injection Guselkumab Injection The risk or severity of adverse effects can be increased when Trabectedin is combined with Guselkumab.
Enasidenib Enasidenib The metabolism of Trabectedin can be increased when combined with Enasidenib.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Trabectedin can be increased when combined with Fosaprepitant.
Delafloxacin Delafloxacin The metabolism of Trabectedin can be increased when combined with Delafloxacin.
Betrixaban Betrixaban The risk or severity of bleeding can be increased when Betrixaban is combined with Trabectedin.
Acalabrutinib Acalabrutinib The metabolism of Trabectedin can be decreased when combined with Acalabrutinib.
Gemtuzumab Ozogamicin Injection Gemtuzumab Ozogamicin Injection The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Trabectedin.
Letermovir Letermovir The metabolism of Letermovir can be decreased when combined with Trabectedin.
Tetrabenazine Tetrabenazine The metabolism of Trabectedin can be decreased when combined with Tetrabenazine.
Buprenorphine Injection Buprenorphine Injection The metabolism of Trabectedin can be decreased when combined with Buprenorphine.
Apalutamide Apalutamide The metabolism of Trabectedin can be increased when combined with Apalutamide.
Penicillamine Penicillamine The risk or severity of adverse effects can be increased when Penicillamine is combined with Trabectedin.
Fostamatinib Fostamatinib The metabolism of Trabectedin can be decreased when combined with Fostamatinib.
Avatrombopag Avatrombopag The metabolism of Trabectedin can be increased when combined with Avatrombopag.
Baricitinib Baricitinib The risk or severity of adverse effects can be increased when Trabectedin is combined with Baricitinib.
Lofexidine Lofexidine The metabolism of Trabectedin can be decreased when combined with Lofexidine.
Eliglustat Eliglustat The metabolism of Trabectedin can be decreased when combined with Eliglustat.
Encorafenib Encorafenib The metabolism of Encorafenib can be decreased when combined with Trabectedin.
Ivosidenib Ivosidenib The metabolism of Trabectedin can be increased when combined with Ivosidenib.
Elagolix Elagolix The metabolism of Elagolix can be decreased when combined with Trabectedin.
Tafenoquine Tafenoquine The metabolism of Tafenoquine can be decreased when combined with Trabectedin.
Cannabidiol Cannabidiol The metabolism of Cannabidiol can be decreased when combined with Trabectedin.
Dacomitinib Dacomitinib The metabolism of Trabectedin can be decreased when combined with Dacomitinib.
Duvelisib Duvelisib The metabolism of Trabectedin can be decreased when combined with Duvelisib.
Stiripentol Stiripentol The metabolism of Trabectedin can be decreased when combined with Stiripentol.
Gilteritinib Gilteritinib The metabolism of Trabectedin can be decreased when combined with Gilteritinib.
Methoxy Polyethylene Glycol-Epoetin Beta Injection Methoxy Polyethylene Glycol-Epoetin Beta Injection The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Trabectedin.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Trabectedin can be increased when combined with Paclitaxel.
Rifamycin Rifamycin The metabolism of Trabectedin can be increased when combined with Rifamycin.
Prucalopride Prucalopride The metabolism of Trabectedin can be decreased when combined with Prucalopride.
Ravulizumab-cwvz Injection Ravulizumab-cwvz Injection The risk or severity of adverse effects can be increased when Trabectedin is combined with Ravulizumab.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Trabectedin can be increased when combined with Emapalumab.
Siponimod Siponimod The metabolism of Siponimod can be decreased when combined with Trabectedin.
Caplacizumab-yhdp Injection Caplacizumab-yhdp Injection The risk or severity of bleeding can be increased when Caplacizumab is combined with Trabectedin.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Trabectedin.
Esomeprazole Injection Esomeprazole Injection The metabolism of Trabectedin can be decreased when combined with Esomeprazole.
Risankizumab-rzaa Injection Risankizumab-rzaa Injection The risk or severity of adverse effects can be increased when Trabectedin is combined with Risankizumab.
Alpelisib Alpelisib The serum concentration of Trabectedin can be decreased when it is combined with Alpelisib.
Cladribine Cladribine The risk or severity of adverse effects can be increased when Cladribine is combined with Trabectedin.
Triclabendazole Triclabendazole The metabolism of Trabectedin can be decreased when combined with Triclabendazole.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Trabectedin.
Pitolisant Pitolisant The serum concentration of Trabectedin can be decreased when it is combined with Pitolisant.
Fedratinib Fedratinib The metabolism of Trabectedin can be decreased when combined with Fedratinib.
Lefamulin Lefamulin The serum concentration of Trabectedin can be increased when it is combined with Lefamulin.
Phenytoin Injection Phenytoin Injection The metabolism of Trabectedin can be decreased when combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Trabectedin can be decreased when combined with Fosphenytoin.
Voxelotor Voxelotor The serum concentration of Voxelotor can be increased when it is combined with Trabectedin.
Avapritinib Avapritinib The metabolism of Avapritinib can be decreased when combined with Trabectedin.
Tazemetostat Tazemetostat The metabolism of Trabectedin can be decreased when combined with Tazemetostat.
Cenobamate Cenobamate The serum concentration of Trabectedin can be decreased when it is combined with Cenobamate.
Ozanimod Ozanimod The risk or severity of adverse effects can be increased when Trabectedin is combined with Ozanimod.
Selumetinib Selumetinib The metabolism of Selumetinib can be decreased when combined with Trabectedin.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Trabectedin.
Fenfluramine Fenfluramine The metabolism of Trabectedin can be decreased when combined with Fenfluramine.
Octreotide Octreotide The serum concentration of Trabectedin can be increased when it is combined with Octreotide.
Pralsetinib Pralsetinib The metabolism of Trabectedin can be increased when combined with Pralsetinib.
Opicapone Opicapone The metabolism of Trabectedin can be increased when combined with Opicapone.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Trabectedin can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Trabectedin can be decreased when combined with Drospirenone.
Vitamin E (Alpha-Tocopherol) Vitamin E (Alpha-Tocopherol) The metabolism of Trabectedin can be increased when combined with Vitamin E.
Theophylline Theophylline The metabolism of Trabectedin can be decreased when combined with Theophylline.
Indomethacin Indomethacin The metabolism of Trabectedin can be decreased when combined with Indomethacin.
Mefenamic Acid Mefenamic Acid The metabolism of Trabectedin can be decreased when combined with Mefenamic acid.
Naproxen Naproxen The metabolism of Trabectedin can be decreased when combined with Naproxen.
Trazodone Trazodone The metabolism of Trabectedin can be decreased when combined with Trazodone.
Isotretinoin Isotretinoin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Isotretinoin is combined with Trabectedin.
Hydroxyurea Hydroxyurea The metabolism of Trabectedin can be decreased when combined with Hydroxyurea.
Floxuridine Floxuridine The metabolism of Trabectedin can be decreased when combined with Floxuridine.
Phenobarbital Phenobarbital The metabolism of Trabectedin can be increased when combined with Phenobarbital.
Methotrexate Injection Methotrexate Injection The risk or severity of adverse effects can be increased when Methotrexate is combined with Trabectedin.
Primidone Primidone The metabolism of Trabectedin can be increased when combined with Primidone.
Methsuximide Methsuximide The metabolism of Trabectedin can be decreased when combined with Methsuximide.
Chlorpromazine Chlorpromazine The metabolism of Trabectedin can be decreased when combined with Chlorpromazine.
Diazepam Diazepam The metabolism of Trabectedin can be decreased when combined with Diazepam.
Flurazepam Flurazepam The metabolism of Trabectedin can be decreased when combined with Flurazepam.
Lorazepam Lorazepam The metabolism of Trabectedin can be decreased when combined with Lorazepam.
Carmustine Carmustine The risk or severity of adverse effects can be increased when Carmustine is combined with Trabectedin.
Codeine Codeine The metabolism of Trabectedin can be decreased when combined with Codeine.
Bromocriptine Bromocriptine The metabolism of Trabectedin can be decreased when combined with Bromocriptine.
Tranylcypromine Tranylcypromine The metabolism of Trabectedin can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine The metabolism of Trabectedin can be decreased when combined with Phenelzine.
Procarbazine Procarbazine The risk or severity of adverse effects can be increased when Procarbazine is combined with Trabectedin.
Tetracycline Tetracycline The metabolism of Trabectedin can be decreased when combined with Tetracycline.
Thioguanine Thioguanine The risk or severity of adverse effects can be increased when Tioguanine is combined with Trabectedin.
Minocycline Minocycline The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Minocycline is combined with Trabectedin.
Prochlorperazine Prochlorperazine The metabolism of Trabectedin can be decreased when combined with Prochlorperazine.
Thioridazine Thioridazine The metabolism of Trabectedin can be decreased when combined with Thioridazine.
Bleomycin Bleomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Trabectedin.
Dapsone Dapsone The metabolism of Trabectedin can be decreased when combined with Dapsone.
Sulfadiazine Sulfadiazine The metabolism of Trabectedin can be decreased when combined with Sulfadiazine.
Oxycodone Oxycodone The metabolism of Trabectedin can be decreased when combined with Oxycodone.
Methadone Methadone The metabolism of Trabectedin can be increased when combined with Methadone.
Oxybutynin Oxybutynin The metabolism of Trabectedin can be decreased when combined with Oxybutynin.
Benztropine Benztropine The metabolism of Trabectedin can be decreased when combined with Benzatropine.
Maprotiline Maprotiline The metabolism of Trabectedin can be decreased when combined with Maprotiline.
Ibuprofen Ibuprofen The metabolism of Trabectedin can be decreased when combined with Ibuprofen.
Orphenadrine Orphenadrine The metabolism of Trabectedin can be decreased when combined with Orphenadrine.
Perphenazine Perphenazine The metabolism of Trabectedin can be decreased when combined with Perphenazine.
Azathioprine Azathioprine The risk or severity of adverse effects can be increased when Azathioprine is combined with Trabectedin.
Fluphenazine Fluphenazine The metabolism of Trabectedin can be decreased when combined with Fluphenazine.
Phentermine Phentermine The metabolism of Trabectedin can be decreased when combined with Phentermine.
Amoxapine Amoxapine The metabolism of Trabectedin can be decreased when combined with Amoxapine.
Sulfasalazine Sulfasalazine The risk or severity of adverse effects can be increased when Sulfasalazine is combined with Trabectedin.
Hydrocortisone Hydrocortisone The metabolism of Trabectedin can be increased when combined with Hydrocortisone.
Lomustine Lomustine The risk or severity of adverse effects can be increased when Lomustine is combined with Trabectedin.
Doxorubicin Doxorubicin The metabolism of Trabectedin can be decreased when combined with Doxorubicin.
Cytarabine Cytarabine The risk or severity of adverse effects can be increased when Cytarabine is combined with Trabectedin.
Mechlorethamine Mechlorethamine The risk or severity of adverse effects can be increased when Mechlorethamine is combined with Trabectedin.
Dactinomycin Dactinomycin The risk or severity of adverse effects can be increased when Dactinomycin is combined with Trabectedin.
Carbamazepine Carbamazepine The metabolism of Trabectedin can be increased when combined with Carbamazepine.
Methyldopa Methyldopa The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Methyldopa is combined with Trabectedin.
Clonidine Clonidine The metabolism of Trabectedin can be decreased when combined with Clonidine.
Hydralazine Hydralazine The metabolism of Trabectedin can be decreased when combined with Hydralazine.
Cimetidine Cimetidine The metabolism of Trabectedin can be decreased when combined with Cimetidine.
Warfarin Warfarin The metabolism of Trabectedin can be increased when combined with Warfarin.
Clonazepam Clonazepam The metabolism of Trabectedin can be decreased when combined with Clonazepam.
Loperamide Loperamide The metabolism of Trabectedin can be decreased when combined with Loperamide.
Promethazine Promethazine The metabolism of Trabectedin can be decreased when combined with Promethazine.
Daunorubicin Daunorubicin The metabolism of Trabectedin can be decreased when combined with Daunorubicin.
Griseofulvin Griseofulvin The metabolism of Trabectedin can be increased when combined with Griseofulvin.
Chloroquine Chloroquine The metabolism of Trabectedin can be decreased when combined with Chloroquine.
Quinine Quinine The metabolism of Trabectedin can be decreased when combined with Quinine.
Ethosuximide Ethosuximide The metabolism of Trabectedin can be decreased when combined with Ethosuximide.
Calcitriol Calcitriol The metabolism of Trabectedin can be increased when combined with Calcitriol.
Sulfinpyrazone Sulfinpyrazone The metabolism of Trabectedin can be increased when combined with Sulfinpyrazone.
Chlorothiazide Chlorothiazide The risk or severity of neutropenia and thrombocytopenia can be increased when Chlorothiazide is combined with Trabectedin.
Secobarbital Secobarbital The metabolism of Trabectedin can be increased when combined with Secobarbital.
Desipramine Desipramine The metabolism of Desipramine can be decreased when combined with Trabectedin.
Amitriptyline Amitriptyline The metabolism of Trabectedin can be decreased when combined with Amitriptyline.
Imipramine Imipramine The metabolism of Imipramine can be decreased when combined with Trabectedin.
Probenecid Probenecid The metabolism of Trabectedin can be increased when combined with Probenecid.
Quinidine Quinidine The metabolism of Trabectedin can be decreased when combined with Quinidine.
Procainamide Procainamide The metabolism of Procainamide can be decreased when combined with Trabectedin.
Isoniazid Isoniazid The metabolism of Trabectedin can be decreased when combined with Isoniazid.
Rifampin Rifampin The metabolism of Trabectedin can be increased when combined with Rifampicin.
Valproic Acid Valproic Acid The metabolism of Valproic acid can be decreased when combined with Trabectedin.
Tamoxifen Tamoxifen The metabolism of Trabectedin can be increased when combined with Tamoxifen.
Mitomycin Mitomycin The risk or severity of adverse effects can be increased when Mitomycin is combined with Trabectedin.
Methimazole Methimazole The metabolism of Trabectedin can be decreased when combined with Methimazole.
Propylthiouracil Propylthiouracil The risk or severity of adverse effects can be increased when Propylthiouracil is combined with Trabectedin.
Chlorpropamide Chlorpropamide The metabolism of Trabectedin can be decreased when combined with Chlorpropamide.
Tolbutamide Tolbutamide The metabolism of Trabectedin can be decreased when combined with Tolbutamide.
Tolazamide Tolazamide The metabolism of Trabectedin can be decreased when combined with Tolazamide.
Dextromethorphan Dextromethorphan The metabolism of Trabectedin can be decreased when combined with Dextromethorphan.
Niacin Niacin The metabolism of Trabectedin can be decreased when combined with Niacin.
Baclofen Baclofen The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Baclofen is combined with Trabectedin.
Clemastine Clemastine The metabolism of Trabectedin can be decreased when combined with Clemastine.
Chlorpheniramine Chlorpheniramine The metabolism of Trabectedin can be decreased when combined with Chlorpheniramine.
Meclizine Meclizine The metabolism of Trabectedin can be decreased when combined with Meclizine.
Methyclothiazide Methyclothiazide The risk or severity of neutropenia and thrombocytopenia can be increased when Methyclothiazide is combined with Trabectedin.
Hydrochlorothiazide Hydrochlorothiazide The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Trabectedin.
Chlorzoxazone Chlorzoxazone The metabolism of Trabectedin can be decreased when combined with Chlorzoxazone.
Danazol Danazol The metabolism of Trabectedin can be decreased when combined with Danazol.
Disulfiram Disulfiram The metabolism of Trabectedin can be decreased when combined with Disulfiram.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The metabolism of Trabectedin can be decreased when combined with Propranolol.
Nortriptyline Nortriptyline The metabolism of Trabectedin can be decreased when combined with Nortriptyline.
Amphotericin B Injection Amphotericin B Injection The metabolism of Trabectedin can be decreased when combined with Amphotericin B.
Mercaptopurine Mercaptopurine The risk or severity of adverse effects can be increased when Mercaptopurine is combined with Trabectedin.
Nadolol Nadolol The metabolism of Trabectedin can be decreased when combined with Nadolol.
Allopurinol Allopurinol The risk or severity of adverse effects can be increased when Allopurinol is combined with Trabectedin.
Fluorouracil Injection Fluorouracil Injection The metabolism of Trabectedin can be decreased when combined with Fluorouracil.
Colchicine Colchicine The metabolism of Trabectedin can be increased when combined with Colchicine.
Cephalexin Cephalexin The metabolism of Trabectedin can be decreased when combined with Cephalexin.
Dacarbazine Dacarbazine The risk or severity of adverse effects can be increased when Dacarbazine is combined with Trabectedin.
Acetazolamide Acetazolamide The metabolism of Trabectedin can be decreased when combined with Acetazolamide.
Bacillus Calmette-Guerin (BCG) Vaccine Bacillus Calmette-Guerin (BCG) Vaccine The risk or severity of infection can be increased when Bacillus calmette-guerin substrain tice live antigen is combined with Trabectedin.
Ketoconazole Ketoconazole The metabolism of Trabectedin can be decreased when combined with Ketoconazole.
Thiotepa Injection Thiotepa Injection The risk or severity of adverse effects can be increased when Thiotepa is combined with Trabectedin.
Vincristine Injection Vincristine Injection The risk or severity of adverse effects can be increased when Vincristine is combined with Trabectedin.
Captopril Captopril The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Captopril is combined with Trabectedin.
Dipyridamole Dipyridamole The risk or severity of bleeding can be increased when Dipyridamole is combined with Trabectedin.
Vinblastine Vinblastine The metabolism of Trabectedin can be increased when combined with Vinblastine.
Metoprolol Metoprolol The metabolism of Trabectedin can be decreased when combined with Metoprolol.
Hydroxyzine Hydroxyzine The metabolism of Trabectedin can be decreased when combined with Hydroxyzine.
Aspirin Aspirin The metabolism of Trabectedin can be decreased when combined with Acetylsalicylic acid.
Chlorambucil Chlorambucil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Trabectedin.
Triazolam Triazolam The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Triazolam is combined with Trabectedin.
Trimethoprim Trimethoprim The metabolism of Trabectedin can be decreased when combined with Trimethoprim.
Diltiazem Diltiazem The metabolism of Trabectedin can be decreased when combined with Diltiazem.
Nifedipine Nifedipine The metabolism of Trabectedin can be increased when combined with Nifedipine.
Timolol Timolol The metabolism of Trabectedin can be decreased when combined with Timolol.
Verapamil Verapamil The metabolism of Trabectedin can be decreased when combined with Verapamil.
Atenolol Atenolol The metabolism of Trabectedin can be decreased when combined with Atenolol.
Pindolol Pindolol The metabolism of Trabectedin can be decreased when combined with Pindolol.
Cisplatin Injection Cisplatin Injection The metabolism of Trabectedin can be decreased when combined with Cisplatin.
Piroxicam Piroxicam The metabolism of Trabectedin can be decreased when combined with Piroxicam.
Bumetanide Bumetanide The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Bumetanide is combined with Trabectedin.
Streptozocin Streptozocin The metabolism of Trabectedin can be increased when combined with Streptozocin.
Etoposide Etoposide The metabolism of Trabectedin can be increased when combined with Etoposide.
Glyburide Glyburide The metabolism of Trabectedin can be decreased when combined with Glyburide.
Glipizide Glipizide The metabolism of Trabectedin can be decreased when combined with Glipizide.
Dicloxacillin Dicloxacillin The metabolism of Trabectedin can be increased when combined with Dicloxacillin.
Nafcillin Injection Nafcillin Injection The metabolism of Trabectedin can be increased when combined with Nafcillin.
Pentoxifylline Pentoxifylline The risk or severity of bleeding can be increased when Pentoxifylline is combined with Trabectedin.
Pentamidine Injection Pentamidine Injection The metabolism of Trabectedin can be decreased when combined with Pentamidine.
Labetalol Labetalol The metabolism of Trabectedin can be decreased when combined with Labetalol.
Leuprolide Injection Leuprolide Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Leuprolide is combined with Trabectedin.
Gemfibrozil Gemfibrozil The metabolism of Trabectedin can be decreased when combined with Gemfibrozil.
Pimozide Pimozide The metabolism of Trabectedin can be decreased when combined with Pimozide.
Enalapril Enalapril The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Enalapril is combined with Trabectedin.
Flurbiprofen Flurbiprofen The metabolism of Trabectedin can be decreased when combined with Flurbiprofen.
Amiodarone Amiodarone The metabolism of Trabectedin can be decreased when combined with Amiodarone.
Buspirone Buspirone The metabolism of Trabectedin can be decreased when combined with Buspirone.
Lovastatin Lovastatin The risk or severity of myopathy and rhabdomyolysis can be increased when Lovastatin is combined with Trabectedin.
Ciprofloxacin Ciprofloxacin The metabolism of Trabectedin can be decreased when combined with Ciprofloxacin.
Diclofenac Diclofenac The metabolism of Trabectedin can be decreased when combined with Diclofenac.
Fluoxetine Fluoxetine The serum concentration of Trabectedin can be increased when it is combined with Fluoxetine.
Interferon Alfa-2b Injection Interferon Alfa-2b Injection The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Trabectedin.
Clozapine Clozapine The risk or severity of neutropenia can be increased when Trabectedin is combined with Clozapine.
Idarubicin Idarubicin The metabolism of Trabectedin can be decreased when combined with Idarubicin.
Ofloxacin Ofloxacin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Ofloxacin is combined with Trabectedin.
Fludarabine Injection Fludarabine Injection The risk or severity of adverse effects can be increased when Fludarabine is combined with Trabectedin.
Pentostatin Injection Pentostatin Injection The risk or severity of adverse effects can be increased when Pentostatin is combined with Trabectedin.
Clarithromycin Clarithromycin The metabolism of Trabectedin can be decreased when combined with Clarithromycin.
Etodolac Etodolac The metabolism of Trabectedin can be decreased when combined with Etodolac.
Felodipine Felodipine The metabolism of Trabectedin can be decreased when combined with Felodipine.
Nabumetone Nabumetone The metabolism of Trabectedin can be decreased when combined with Nabumetone.
Pravastatin Pravastatin The risk or severity of myopathy and rhabdomyolysis can be increased when Pravastatin is combined with Trabectedin.
Simvastatin Simvastatin The risk or severity of myopathy and rhabdomyolysis can be increased when Simvastatin is combined with Trabectedin.
Epoetin Alfa, Injection Epoetin Alfa, Injection The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Trabectedin.
Teniposide Injection Teniposide Injection The metabolism of Trabectedin can be decreased when combined with Teniposide.
Itraconazole Itraconazole The metabolism of Trabectedin can be decreased when combined with Itraconazole.
Atovaquone Atovaquone The metabolism of Trabectedin can be decreased when combined with Atovaquone.
Rifabutin Rifabutin The metabolism of Trabectedin can be increased when combined with Rifabutin.
Sotalol Sotalol The metabolism of Sotalol can be decreased when combined with Trabectedin.
Zolpidem Zolpidem The metabolism of Trabectedin can be decreased when combined with Zolpidem.
Doxazosin Doxazosin The metabolism of Trabectedin can be decreased when combined with Doxazosin.
Isradipine Isradipine The metabolism of Trabectedin can be decreased when combined with Isradipine.
Omeprazole Omeprazole The metabolism of Trabectedin can be increased when combined with Omeprazole.
Cisapride Cisapride The metabolism of Trabectedin can be decreased when combined with Cisapride.
Fluvastatin Fluvastatin The risk or severity of myopathy and rhabdomyolysis can be increased when Fluvastatin is combined with Trabectedin.
Venlafaxine Venlafaxine The metabolism of Trabectedin can be decreased when combined with Venlafaxine.
Nizatidine Nizatidine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Nizatidine is combined with Trabectedin.
Stavudine Stavudine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Stavudine is combined with Trabectedin.
Famciclovir Famciclovir The metabolism of Trabectedin can be decreased when combined with Famciclovir.
Fluvoxamine Fluvoxamine The metabolism of Trabectedin can be decreased when combined with Fluvoxamine.
Nefazodone Nefazodone The metabolism of Trabectedin can be decreased when combined with Nefazodone.
Losartan Losartan The metabolism of Trabectedin can be decreased when combined with Losartan.
Tramadol Tramadol The metabolism of Trabectedin can be decreased when combined with Tramadol.
Vinorelbine Injection Vinorelbine Injection The metabolism of Trabectedin can be decreased when combined with Vinorelbine.
Carboplatin Injection Carboplatin Injection The risk or severity of adverse effects can be increased when Carboplatin is combined with Trabectedin.
Lansoprazole Lansoprazole The metabolism of Trabectedin can be increased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The metabolism of Trabectedin can be increased when combined with Ifosfamide.
Pegaspargase Injection Pegaspargase Injection The risk or severity of adverse effects can be increased when Pegaspargase is combined with Trabectedin.
Nicardipine Nicardipine The metabolism of Trabectedin can be decreased when combined with Nicardipine.
Bupropion Bupropion The metabolism of Trabectedin can be decreased when combined with Bupropion.
Ticlopidine Ticlopidine The metabolism of Trabectedin can be decreased when combined with Ticlopidine.
Saquinavir Saquinavir The metabolism of Saquinavir can be decreased when combined with Trabectedin.
Dalteparin Injection Dalteparin Injection The risk or severity of bleeding can be increased when Dalteparin is combined with Trabectedin.
Lamivudine Lamivudine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Lamivudine is combined with Trabectedin.
Glimepiride Glimepiride The metabolism of Trabectedin can be decreased when combined with Glimepiride.
Gemcitabine Injection Gemcitabine Injection The risk or severity of adverse effects can be increased when Gemcitabine is combined with Trabectedin.
Indinavir Indinavir The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Indinavir is combined with Trabectedin.
Ritonavir Ritonavir The metabolism of Trabectedin can be decreased when combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Trabectedin can be decreased when combined with Docetaxel.
Clomipramine Clomipramine The metabolism of Trabectedin can be decreased when combined with Clomipramine.
Zafirlukast Zafirlukast The metabolism of Trabectedin can be decreased when combined with Zafirlukast.
Mirtazapine Mirtazapine The metabolism of Trabectedin can be decreased when combined with Mirtazapine.
Topiramate Topiramate The metabolism of Trabectedin can be increased when combined with Topiramate.
Zileuton Zileuton The metabolism of Trabectedin can be decreased when combined with Zileuton.
Valsartan Valsartan The metabolism of Trabectedin can be decreased when combined with Valsartan.
Donepezil Donepezil The metabolism of Trabectedin can be decreased when combined with Donepezil.
Nelfinavir Nelfinavir The metabolism of Trabectedin can be decreased when combined with Nelfinavir.
Azithromycin Azithromycin The metabolism of Trabectedin can be decreased when combined with Azithromycin.
Carvedilol Carvedilol The metabolism of Trabectedin can be decreased when combined with Carvedilol.
Nilutamide Nilutamide The metabolism of Trabectedin can be decreased when combined with Nilutamide.
Selegiline Selegiline The metabolism of Trabectedin can be decreased when combined with Selegiline.
Bicalutamide Bicalutamide The metabolism of Trabectedin can be decreased when combined with Bicalutamide.
Sertraline Sertraline The metabolism of Trabectedin can be decreased when combined with Sertraline.
Propafenone Propafenone The metabolism of Trabectedin can be decreased when combined with Propafenone.
Letrozole Letrozole The metabolism of Trabectedin can be decreased when combined with Letrozole.
Raloxifene Raloxifene The metabolism of Trabectedin can be decreased when combined with Raloxifene.
Irbesartan Irbesartan The metabolism of Trabectedin can be decreased when combined with Irbesartan.
Tamsulosin Tamsulosin The metabolism of Trabectedin can be decreased when combined with Tamsulosin.
Quetiapine Quetiapine The metabolism of Trabectedin can be decreased when combined with Quetiapine.
Paroxetine Paroxetine The metabolism of Trabectedin can be decreased when combined with Paroxetine.
Tolcapone Tolcapone The metabolism of Trabectedin can be decreased when combined with Tolcapone.
Citalopram Citalopram The metabolism of Trabectedin can be decreased when combined with Citalopram.
Capecitabine Capecitabine The metabolism of Trabectedin can be decreased when combined with Capecitabine.
Efavirenz Efavirenz The metabolism of Trabectedin can be decreased when combined with Efavirenz.
Sildenafil Sildenafil The metabolism of Trabectedin can be decreased when combined with Sildenafil.
Trastuzumab Injection Trastuzumab Injection Trastuzumab may increase the neutropenic activities of Trabectedin.
Celecoxib Celecoxib The metabolism of Trabectedin can be decreased when combined with Celecoxib.
Rosiglitazone Rosiglitazone The metabolism of Trabectedin can be decreased when combined with Rosiglitazone.
Tolterodine Tolterodine The metabolism of Trabectedin can be decreased when combined with Tolterodine.
Thalidomide Thalidomide The metabolism of Trabectedin can be decreased when combined with Thalidomide.
Nateglinide Nateglinide The metabolism of Trabectedin can be decreased when combined with Nateglinide.
Galantamine Galantamine The metabolism of Trabectedin can be decreased when combined with Galantamine.
Rabeprazole Rabeprazole The metabolism of Trabectedin can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Trabectedin can be decreased when combined with Terbinafine.

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