Zanubrutinib

Generic name: Pronounced as (zan" ue broo' ti nib)
Brand names
  • Brukinsa®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 03/15/2023

Zanubrutinib is used to treat mantle cell lymphoma (MCL; a fast-growing cancer that begins in the cells of the immune system) in adults who have already been treated with at least one other chemotherapy medication. Zanubrutinib is also used to treat adults with Waldenstrom's macroglobulinemia (WM; a slow-growing cancer that begins in certain white blood cells in your bone marrow), chronic lymphocytic leukemia (CLL; a type of cancer that begins in the white blood cells), and small lymphocytic lymphoma (SLL; a type of cancer that begins mostly in the lymph nodes). It is also used to treat marginal zone lymphoma (MZL; a slow growing cancer that begins in a type of white blood cells that normally fight infection) in adults whose cancer has returned or did not respond to a certain type of medication. Zanubrutinib is in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps stop the spread of cancer cells.

Zanubrutinib comes as a capsule to take by mouth. It is usually taken once or twice daily with or without food. Take zanubrutinib at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take zanubrutinib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the capsules whole with a glass of water; do not open, chew, or crush them.

Your doctor may decrease your dose, or interrupt or discontinue your treatment. This depends on how well the medication works for you and the side effects you experience. Talk to your doctor about how you are feeling during your treatment. Continue to take zanubrutinib even if you feel well. Do not stop taking zanubrutinib without talking to your doctor.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking zanubrutinib,

  • tell your doctor and pharmacist if you are allergic to zanubrutinib, any other medications, or any of the ingredients in zanubrutinib capsules. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • The following nonprescription or herbal products may interact with zanubrutinib: omeprazole (Prilosec OTC, Zegerid OTC) and St. John's Wort. Be sure to let your healthcare provider know that you are taking these medications before you start taking zanubrutinib. Do not start any of these medications while receiving taking zanubrutinib without discussing with your healthcare provider.

  • tell your doctor if you have an infection or recently had surgery. Also tell your doctor if you have or have ever had hepatitis B (HBV, a virus that infects the liver and may cause severe liver damage), an irregular heartbeat, high blood pressure, bleeding problems, or heart or liver disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or if you plan on fathering a child. You should not become pregnant while you are taking zanubrutinib. If you are female, you will need to take a pregnancy test before you start treatment and should use birth control to prevent pregnancy during your treatment and for 1 week after your final dose. If you are male, you and your female partner should use birth control during your treatment with zanubrutinib and continue for 1 week after your final dose. If you or your partner become pregnant while taking zanubrutinib, call your doctor immediately. Zanubrutinib can cause fetal harm.

  • tell your doctor if you are breast-feeding. Do not breastfeed while you are taking zanubrutinib and for 2 weeks after your final dose.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking zanubrutinib. Your doctor may tell you to stop taking zanubrutinib for a period of time before and after the surgery or procedure.

  • plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Zanubrutinib may make your skin sensitive to the dangerous effects of the sunlight, and may increase your risk of developing skin cancer.

Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medication.

Take the missed dose as soon as you remember it that day and continue your regular dosing schedule the next day. Do not take a double dose to make up for a missed one.

  • Zanubrutinib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • diarrhea

    • constipation

    • nausea

    • vomiting

    • cough

    • muscle, joint, or back pain

    • rash

    • headache

    • tiredness

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

    • fever, sore throat, cough, chills, or other signs of infection

    • painful, frequent, or urgent urination

    • unusual bruising or bleeding

    • blood in your stools or black, tarry stools; pink or brown urine; vomiting blood or coffee ground vomit; coughing up blood

    • feeling dizzy, weak, or confused; changes in speech; headache that lasts a long time

    • fast or irregular heartbeat, palpitations, feeling lightheaded or dizzy, fainting, shortness of breath, chest pain

  • Zanubrutinib may increase your risk of developing other cancers, including skin cancer. Talk to your doctor about the risks of taking zanubrutinib.

  • Zanubrutinib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to zanubrutinib.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Delavirdine Delavirdine The metabolism of Zanubrutinib can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Zanubrutinib can be decreased when combined with Nevirapine.
Clopidogrel Clopidogrel The metabolism of Zanubrutinib can be decreased when combined with Clopidogrel.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The metabolism of Zanubrutinib can be decreased when combined with Erythromycin.
Fenofibrate Fenofibrate The metabolism of Zanubrutinib can be decreased when combined with Fenofibrate.
Methylergonovine Methylergonovine The metabolism of Zanubrutinib can be decreased when combined with Methylergometrine.
Tacrolimus Tacrolimus The metabolism of Zanubrutinib can be decreased when combined with Tacrolimus.
Triamcinolone Triamcinolone The metabolism of Zanubrutinib can be increased when combined with Triamcinolone.
Doxycycline Injection Doxycycline Injection The metabolism of Zanubrutinib can be decreased when combined with Doxycycline.
Fluconazole Injection Fluconazole Injection The metabolism of Zanubrutinib can be decreased when combined with Fluconazole.
Meperidine Injection Meperidine Injection The metabolism of Zanubrutinib can be increased when combined with Meperidine.
Methylprednisolone Injection Methylprednisolone Injection The metabolism of Zanubrutinib can be increased when combined with Methylprednisolone.
Metronidazole Injection Metronidazole Injection The metabolism of Zanubrutinib can be decreased when combined with Metronidazole.
Cyclosporine Cyclosporine The metabolism of Zanubrutinib can be decreased when combined with Cyclosporine.
Orlistat Orlistat The metabolism of Zanubrutinib can be increased when combined with Orlistat.
Oxcarbazepine Oxcarbazepine The metabolism of Zanubrutinib can be increased when combined with Oxcarbazepine.
Anakinra Anakinra The metabolism of Zanubrutinib can be increased when combined with Anakinra.
Trimipramine Trimipramine The metabolism of Zanubrutinib can be decreased when combined with Trimipramine.
Etanercept Injection Etanercept Injection The metabolism of Zanubrutinib can be increased when combined with Etanercept.
Modafinil Modafinil The metabolism of Zanubrutinib can be increased when combined with Modafinil.
Tenofovir Tenofovir The metabolism of Zanubrutinib can be decreased when combined with Tenofovir.
Epinephrine Injection Epinephrine Injection The metabolism of Zanubrutinib can be decreased when combined with Epinephrine.
Adalimumab Injection Adalimumab Injection The metabolism of Zanubrutinib can be increased when combined with Adalimumab.
Atazanavir Atazanavir The metabolism of Zanubrutinib can be decreased when combined with Atazanavir.
Mefloquine Mefloquine The metabolism of Zanubrutinib can be decreased when combined with Mefloquine.
Rosuvastatin Rosuvastatin The metabolism of Zanubrutinib can be decreased when combined with Rosuvastatin.
Aprepitant Aprepitant The metabolism of Zanubrutinib can be decreased when combined with Aprepitant.
Memantine Memantine The metabolism of Zanubrutinib can be decreased when combined with Memantine.
Progesterone Progesterone The metabolism of Zanubrutinib can be increased when combined with Progesterone.
Apomorphine Injection Apomorphine Injection The metabolism of Zanubrutinib can be decreased when combined with Apomorphine.
Darbepoetin Alfa Injection Darbepoetin Alfa Injection The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Zanubrutinib.
Infliximab Injection Infliximab Injection The metabolism of Zanubrutinib can be increased when combined with Infliximab.
Rifaximin Rifaximin The metabolism of Zanubrutinib can be increased when combined with Rifaximin.
Duloxetine Duloxetine The metabolism of Zanubrutinib can be decreased when combined with Duloxetine.
Norethindrone Norethindrone The metabolism of Zanubrutinib can be decreased when combined with Norethisterone.
Bosentan Bosentan The metabolism of Zanubrutinib can be increased when combined with Bosentan.
Erlotinib Erlotinib The metabolism of Zanubrutinib can be decreased when combined with Erlotinib.
Voriconazole Voriconazole The metabolism of Zanubrutinib can be decreased when combined with Voriconazole.
Deferasirox Deferasirox The metabolism of Zanubrutinib can be increased when combined with Deferasirox.
Tipranavir Tipranavir The metabolism of Zanubrutinib can be decreased when combined with Tipranavir.
Felbamate Felbamate The metabolism of Zanubrutinib can be increased when combined with Felbamate.
Ranolazine Ranolazine The metabolism of Zanubrutinib can be decreased when combined with Ranolazine.
Abatacept Injection Abatacept Injection The metabolism of Zanubrutinib can be increased when combined with Abatacept.
Imatinib Imatinib The metabolism of Zanubrutinib can be decreased when combined with Imatinib.
Gefitinib Gefitinib The metabolism of Zanubrutinib can be decreased when combined with Gefitinib.
Posaconazole Posaconazole The metabolism of Zanubrutinib can be decreased when combined with Posaconazole.
Primaquine Primaquine The metabolism of Zanubrutinib can be decreased when combined with Primaquine.
Darunavir Darunavir The serum concentration of Zanubrutinib can be increased when it is combined with Darunavir.
Sorafenib Sorafenib The metabolism of Zanubrutinib can be decreased when combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Zanubrutinib can be decreased when combined with Sunitinib.
Lapatinib Lapatinib The metabolism of Zanubrutinib can be decreased when combined with Lapatinib.
Dasatinib Dasatinib The metabolism of Zanubrutinib can be decreased when combined with Dasatinib.
Mexiletine Mexiletine The metabolism of Zanubrutinib can be decreased when combined with Mexiletine.
Armodafinil Armodafinil The metabolism of Zanubrutinib can be increased when combined with Armodafinil.
Ivermectin Ivermectin The metabolism of Zanubrutinib can be increased when combined with Ivermectin.
Nilotinib Nilotinib The metabolism of Zanubrutinib can be decreased when combined with Nilotinib.
Bexarotene Bexarotene The metabolism of Zanubrutinib can be increased when combined with Bexarotene.
Budesonide Budesonide The metabolism of Zanubrutinib can be increased when combined with Budesonide.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Zanubrutinib can be decreased when combined with Chloramphenicol.
Etravirine Etravirine The metabolism of Zanubrutinib can be increased when combined with Etravirine.
Mitoxantrone Injection Mitoxantrone Injection The metabolism of Zanubrutinib can be decreased when combined with Mitoxantrone.
Desvenlafaxine Desvenlafaxine The metabolism of Zanubrutinib can be decreased when combined with Desvenlafaxine.
Tretinoin Tretinoin The metabolism of Zanubrutinib can be decreased when combined with Tretinoin.
Pilocarpine Pilocarpine The metabolism of Zanubrutinib can be decreased when combined with Pilocarpine.
Certolizumab Injection Certolizumab Injection The metabolism of Zanubrutinib can be increased when combined with Certolizumab pegol.
Irinotecan Injection Irinotecan Injection The metabolism of Zanubrutinib can be decreased when combined with Irinotecan.
Mitotane Mitotane The metabolism of Zanubrutinib can be increased when combined with Mitotane.
Rufinamide Rufinamide The metabolism of Zanubrutinib can be increased when combined with Rufinamide.
Midazolam Midazolam The metabolism of Zanubrutinib can be decreased when combined with Midazolam.
Milnacipran Milnacipran The metabolism of Zanubrutinib can be decreased when combined with Milnacipran.
Prasugrel Prasugrel The metabolism of Zanubrutinib can be decreased when combined with Prasugrel.
Lacosamide Lacosamide The metabolism of Zanubrutinib can be decreased when combined with Lacosamide.
Dronedarone Dronedarone The metabolism of Zanubrutinib can be decreased when combined with Dronedarone.
Romidepsin Injection Romidepsin Injection The metabolism of Zanubrutinib can be decreased when combined with Romidepsin.
Topotecan Topotecan The metabolism of Zanubrutinib can be increased when combined with Topotecan.
Golimumab Injection Golimumab Injection The metabolism of Zanubrutinib can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Zanubrutinib can be decreased when combined with Pazopanib.
Albendazole Albendazole The metabolism of Zanubrutinib can be decreased when combined with Albendazole.
Tocilizumab Injection Tocilizumab Injection The metabolism of Zanubrutinib can be increased when combined with Tocilizumab.
Acetaminophen Injection Acetaminophen Injection The metabolism of Zanubrutinib can be increased when combined with Acetaminophen.
Denileukin Diftitox Injection Denileukin Diftitox Injection The metabolism of Zanubrutinib can be decreased when combined with Aldesleukin.
Roflumilast Roflumilast The metabolism of Zanubrutinib can be decreased when combined with Roflumilast.
Linagliptin Linagliptin The metabolism of Zanubrutinib can be decreased when combined with Linagliptin.
Rilpivirine Rilpivirine The metabolism of Zanubrutinib can be decreased when combined with Rilpivirine.
Telaprevir Telaprevir The metabolism of Zanubrutinib can be decreased when combined with Glecaprevir.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Zanubrutinib can be increased when combined with Cyclophosphamide.
Ticagrelor Ticagrelor The metabolism of Zanubrutinib can be decreased when combined with Ticagrelor.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Zanubrutinib can be decreased when combined with Brentuximab vedotin.
Clobazam Clobazam The metabolism of Zanubrutinib can be increased when combined with Clobazam.
Vemurafenib Vemurafenib The metabolism of Zanubrutinib can be increased when combined with Vemurafenib.
Ivacaftor Ivacaftor The metabolism of Zanubrutinib can be decreased when combined with Ivacaftor.
Crizotinib Crizotinib The metabolism of Zanubrutinib can be decreased when combined with Crizotinib.
Cabergoline Cabergoline The metabolism of Zanubrutinib can be decreased when combined with Cabergoline.
Naloxone Injection Naloxone Injection The metabolism of Zanubrutinib can be decreased when combined with Naloxone.
Enzalutamide Enzalutamide The metabolism of Zanubrutinib can be increased when combined with Enzalutamide.
Regorafenib Regorafenib The metabolism of Zanubrutinib can be decreased when combined with Regorafenib.
Bosutinib Bosutinib The metabolism of Zanubrutinib can be decreased when combined with Bosutinib.
Corticotropin, Repository Injection Corticotropin, Repository Injection The metabolism of Zanubrutinib can be increased when combined with Corticotropin.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Zanubrutinib can be decreased when combined with Trastuzumab emtansine.
Dabrafenib Dabrafenib The metabolism of Zanubrutinib can be increased when combined with Dabrafenib.
Ospemifene Ospemifene The metabolism of Zanubrutinib can be decreased when combined with Ospemifene.
Trametinib Trametinib The metabolism of Zanubrutinib can be increased when combined with Trametinib.
Vortioxetine Vortioxetine The metabolism of Zanubrutinib can be decreased when combined with Vortioxetine.
Perampanel Perampanel The metabolism of Zanubrutinib can be increased when combined with Perampanel.
Lomitapide Lomitapide The metabolism of Zanubrutinib can be decreased when combined with Lomitapide.
Simeprevir Simeprevir The metabolism of Zanubrutinib can be decreased when combined with Simeprevir.
Apremilast Apremilast The metabolism of Zanubrutinib can be increased when combined with Apremilast.
Ceritinib Ceritinib The metabolism of Zanubrutinib can be decreased when combined with Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Zanubrutinib can be increased when combined with Siltuximab.
Eslicarbazepine Eslicarbazepine The metabolism of Zanubrutinib can be increased when combined with Eslicarbazepine.
Idelalisib Idelalisib The metabolism of Zanubrutinib can be decreased when combined with Idelalisib.
Testosterone Injection Testosterone Injection The metabolism of Zanubrutinib can be increased when combined with Testosterone.
Oritavancin Injection Oritavancin Injection The metabolism of Zanubrutinib can be increased when combined with Oritavancin.
Vorapaxar Vorapaxar The metabolism of Zanubrutinib can be decreased when combined with Vorapaxar.
Hydrocodone Hydrocodone The metabolism of Zanubrutinib can be decreased when combined with Hydrocodone.
Suvorexant Suvorexant The metabolism of Zanubrutinib can be decreased when combined with Suvorexant.
Olaparib Olaparib The metabolism of Zanubrutinib can be decreased when combined with Olaparib.
Tasimelteon Tasimelteon The metabolism of Zanubrutinib can be decreased when combined with Tasimelteon.
Lanreotide Injection Lanreotide Injection The metabolism of Zanubrutinib can be decreased when combined with Lanreotide.
Nintedanib Nintedanib The metabolism of Zanubrutinib can be decreased when combined with Nintedanib.
Secukinumab Injection Secukinumab Injection The metabolism of Zanubrutinib can be increased when combined with Secukinumab.
Palbociclib Palbociclib The metabolism of Zanubrutinib can be decreased when combined with Palbociclib.
Lenvatinib Lenvatinib The metabolism of Zanubrutinib can be increased when combined with Lenvatinib.
Haloperidol Injection Haloperidol Injection The metabolism of Zanubrutinib can be decreased when combined with Haloperidol.
Isavuconazonium Injection Isavuconazonium Injection The metabolism of Zanubrutinib can be decreased when combined with Isavuconazonium.
Prednisolone Prednisolone The metabolism of Zanubrutinib can be increased when combined with Prednisolone.
Ziprasidone Injection Ziprasidone Injection The metabolism of Zanubrutinib can be decreased when combined with Ziprasidone.
Cobimetinib Cobimetinib The metabolism of Zanubrutinib can be decreased when combined with Cobimetinib.
Osimertinib Osimertinib The metabolism of Zanubrutinib can be increased when combined with Osimertinib.
Rifapentine Rifapentine The metabolism of Zanubrutinib can be increased when combined with Rifapentine.
Lesinurad Lesinurad The metabolism of Zanubrutinib can be increased when combined with Lesinurad.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The metabolism of Zanubrutinib can be decreased when combined with Amphotericin B.
Dexamethasone Injection Dexamethasone Injection The metabolism of Zanubrutinib can be increased when combined with Dexamethasone.
Brivaracetam Injection Brivaracetam Injection The metabolism of Zanubrutinib can be decreased when combined with Brivaracetam.
Venetoclax Venetoclax The metabolism of Zanubrutinib can be decreased when combined with Venetoclax.
Cobicistat Cobicistat The metabolism of Zanubrutinib can be decreased when combined with Cobicistat.
Rucaparib Rucaparib The metabolism of Zanubrutinib can be decreased when combined with Rucaparib.
Ribociclib Ribociclib The metabolism of Zanubrutinib can be decreased when combined with Ribociclib.
Brigatinib Brigatinib The metabolism of Zanubrutinib can be increased when combined with Brigatinib.
Deflazacort Deflazacort The metabolism of Zanubrutinib can be increased when combined with Deflazacort.
Safinamide Safinamide The metabolism of Zanubrutinib can be decreased when combined with Safinamide.
Sarilumab Injection Sarilumab Injection The metabolism of Zanubrutinib can be increased when combined with Sarilumab.
Midostaurin Midostaurin The metabolism of Zanubrutinib can be increased when combined with Midostaurin.
Enasidenib Enasidenib The metabolism of Zanubrutinib can be increased when combined with Enasidenib.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Zanubrutinib can be increased when combined with Fosaprepitant.
Acalabrutinib Acalabrutinib The metabolism of Zanubrutinib can be decreased when combined with Acalabrutinib.
Letermovir Letermovir The metabolism of Zanubrutinib can be decreased when combined with Letermovir.
Buprenorphine Injection Buprenorphine Injection The metabolism of Zanubrutinib can be decreased when combined with Buprenorphine.
Apalutamide Apalutamide The metabolism of Zanubrutinib can be increased when combined with Apalutamide.
Fostamatinib Fostamatinib The metabolism of Zanubrutinib can be decreased when combined with Fostamatinib.
Ivosidenib Ivosidenib The metabolism of Zanubrutinib can be increased when combined with Ivosidenib.
Dacomitinib Dacomitinib The metabolism of Zanubrutinib can be decreased when combined with Dacomitinib.
Duvelisib Duvelisib The metabolism of Zanubrutinib can be decreased when combined with Duvelisib.
Stiripentol Stiripentol The metabolism of Zanubrutinib can be decreased when combined with Stiripentol.
Gilteritinib Gilteritinib The metabolism of Zanubrutinib can be decreased when combined with Gilteritinib.
Lorlatinib Lorlatinib The metabolism of Zanubrutinib can be increased when combined with Lorlatinib.
Methoxy Polyethylene Glycol-Epoetin Beta Injection Methoxy Polyethylene Glycol-Epoetin Beta Injection The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Zanubrutinib.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Zanubrutinib can be increased when combined with Paclitaxel.
Rifamycin Rifamycin The metabolism of Zanubrutinib can be increased when combined with Rifamycin.
Prucalopride Prucalopride The metabolism of Zanubrutinib can be decreased when combined with Prucalopride.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Zanubrutinib can be increased when combined with Emapalumab.
Siponimod Siponimod The metabolism of Zanubrutinib can be decreased when combined with Siponimod.
Alpelisib Alpelisib The metabolism of Zanubrutinib can be increased when combined with Alpelisib.
Triclabendazole Triclabendazole The metabolism of Zanubrutinib can be decreased when combined with Triclabendazole.
Istradefylline Istradefylline The metabolism of Zanubrutinib can be decreased when combined with Istradefylline.
Pitolisant Pitolisant The serum concentration of Zanubrutinib can be decreased when it is combined with Pitolisant.
Lefamulin Lefamulin The serum concentration of Zanubrutinib can be increased when it is combined with Lefamulin.
Phenytoin Injection Phenytoin Injection The metabolism of Zanubrutinib can be increased when combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Zanubrutinib can be increased when combined with Fosphenytoin.
Voxelotor Voxelotor The serum concentration of Zanubrutinib can be increased when it is combined with Voxelotor.
Tazemetostat Tazemetostat The metabolism of Zanubrutinib can be decreased when combined with Tazemetostat.
Cenobamate Cenobamate The serum concentration of Zanubrutinib can be decreased when it is combined with Cenobamate.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Zanubrutinib.
Lemborexant Lemborexant The metabolism of Zanubrutinib can be increased when combined with Lemborexant.
Octreotide Octreotide The serum concentration of Zanubrutinib can be increased when it is combined with Octreotide.
Pralsetinib Pralsetinib The metabolism of Zanubrutinib can be increased when combined with Pralsetinib.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Zanubrutinib can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Zanubrutinib can be decreased when combined with Drospirenone.
Vitamin E (Alpha-Tocopherol) Vitamin E (Alpha-Tocopherol) The metabolism of Zanubrutinib can be increased when combined with Vitamin E.
Phenobarbital Phenobarbital The metabolism of Zanubrutinib can be increased when combined with Phenobarbital.
Primidone Primidone The metabolism of Zanubrutinib can be increased when combined with Primidone.
Chlorpromazine Chlorpromazine The metabolism of Zanubrutinib can be increased when combined with Chlorpromazine.
Diazepam Diazepam The metabolism of Zanubrutinib can be decreased when combined with Diazepam.
Lorazepam Lorazepam The metabolism of Zanubrutinib can be decreased when combined with Lorazepam.
Bromocriptine Bromocriptine The metabolism of Zanubrutinib can be decreased when combined with Bromocriptine.
Tranylcypromine Tranylcypromine The metabolism of Zanubrutinib can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine The metabolism of Zanubrutinib can be decreased when combined with Phenelzine.
Tetracycline Tetracycline The metabolism of Zanubrutinib can be decreased when combined with Tetracycline.
Prochlorperazine Prochlorperazine The metabolism of Zanubrutinib can be decreased when combined with Prochlorperazine.
Methadone Methadone The metabolism of Zanubrutinib can be increased when combined with Methadone.
Oxybutynin Oxybutynin The metabolism of Zanubrutinib can be decreased when combined with Oxybutynin.
Orphenadrine Orphenadrine The metabolism of Zanubrutinib can be decreased when combined with Orphenadrine.
Phentermine Phentermine The metabolism of Zanubrutinib can be decreased when combined with Phentermine.
Hydrocortisone Hydrocortisone The metabolism of Zanubrutinib can be increased when combined with Hydrocortisone.
Doxorubicin Doxorubicin The metabolism of Zanubrutinib can be decreased when combined with Doxorubicin.
Carbamazepine Carbamazepine The metabolism of Zanubrutinib can be increased when combined with Carbamazepine.
Hydralazine Hydralazine The metabolism of Zanubrutinib can be decreased when combined with Hydralazine.
Cimetidine Cimetidine The metabolism of Zanubrutinib can be decreased when combined with Cimetidine.
Warfarin Warfarin The metabolism of Zanubrutinib can be increased when combined with Warfarin.
Loperamide Loperamide The metabolism of Zanubrutinib can be decreased when combined with Loperamide.
Promethazine Promethazine The metabolism of Zanubrutinib can be decreased when combined with Promethazine.
Daunorubicin Daunorubicin The metabolism of Zanubrutinib can be decreased when combined with Daunorubicin.
Griseofulvin Griseofulvin The metabolism of Zanubrutinib can be increased when combined with Griseofulvin.
Quinine Quinine The metabolism of Zanubrutinib can be increased when combined with Quinine.
Calcitriol Calcitriol The metabolism of Zanubrutinib can be increased when combined with Calcitriol.
Sulfinpyrazone Sulfinpyrazone The metabolism of Zanubrutinib can be increased when combined with Sulfinpyrazone.
Secobarbital Secobarbital The metabolism of Zanubrutinib can be increased when combined with Secobarbital.
Desipramine Desipramine The metabolism of Zanubrutinib can be decreased when combined with Desipramine.
Amitriptyline Amitriptyline The metabolism of Zanubrutinib can be decreased when combined with Amitriptyline.
Imipramine Imipramine The metabolism of Zanubrutinib can be decreased when combined with Imipramine.
Probenecid Probenecid The metabolism of Zanubrutinib can be increased when combined with Probenecid.
Quinidine Quinidine The metabolism of Zanubrutinib can be decreased when combined with Quinidine.
Isoniazid Isoniazid The metabolism of Zanubrutinib can be decreased when combined with Isoniazid.
Rifampin Rifampin The metabolism of Zanubrutinib can be increased when combined with Rifampicin.
Valproic Acid Valproic Acid The metabolism of Zanubrutinib can be decreased when combined with Valproic acid.
Tamoxifen Tamoxifen The metabolism of Zanubrutinib can be increased when combined with Tamoxifen.
Methimazole Methimazole The metabolism of Zanubrutinib can be decreased when combined with Methimazole.
Niacin Niacin The metabolism of Zanubrutinib can be decreased when combined with Niacin.
Brompheniramine Brompheniramine The metabolism of Zanubrutinib can be decreased when combined with Brompheniramine.
Danazol Danazol The metabolism of Zanubrutinib can be decreased when combined with Danazol.
Amphotericin B Injection Amphotericin B Injection The metabolism of Zanubrutinib can be decreased when combined with Amphotericin B.
Colchicine Colchicine The metabolism of Zanubrutinib can be increased when combined with Colchicine.
Cephalexin Cephalexin The metabolism of Zanubrutinib can be decreased when combined with Cephalexin.
Acetazolamide Acetazolamide The metabolism of Zanubrutinib can be decreased when combined with Acetazolamide.
Ketoconazole Ketoconazole The metabolism of Zanubrutinib can be decreased when combined with Ketoconazole.
Thiotepa Injection Thiotepa Injection The metabolism of Zanubrutinib can be decreased when combined with Thiotepa.
Vinblastine Vinblastine The metabolism of Zanubrutinib can be increased when combined with Vinblastine.
Metoprolol Metoprolol The metabolism of Zanubrutinib can be decreased when combined with Metoprolol.
Diltiazem Diltiazem The metabolism of Zanubrutinib can be decreased when combined with Diltiazem.
Nifedipine Nifedipine The metabolism of Zanubrutinib can be increased when combined with Nifedipine.
Verapamil Verapamil The metabolism of Zanubrutinib can be decreased when combined with Verapamil.
Cisplatin Injection Cisplatin Injection The metabolism of Zanubrutinib can be decreased when combined with Cisplatin.
Etoposide Etoposide The metabolism of Zanubrutinib can be increased when combined with Etoposide.
Glyburide Glyburide The metabolism of Zanubrutinib can be decreased when combined with Glyburide.
Dicloxacillin Dicloxacillin The metabolism of Zanubrutinib can be increased when combined with Dicloxacillin.
Nafcillin Injection Nafcillin Injection The metabolism of Zanubrutinib can be increased when combined with Nafcillin.
Pimozide Pimozide The metabolism of Zanubrutinib can be decreased when combined with Pimozide.
Amiodarone Amiodarone The metabolism of Zanubrutinib can be decreased when combined with Amiodarone.
Lovastatin Lovastatin The metabolism of Zanubrutinib can be decreased when combined with Lovastatin.
Ciprofloxacin Ciprofloxacin The metabolism of Zanubrutinib can be decreased when combined with Ciprofloxacin.
Diclofenac Diclofenac The metabolism of Zanubrutinib can be decreased when combined with Diclofenac.
Fluoxetine Fluoxetine The metabolism of Zanubrutinib can be decreased when combined with Fluoxetine.
Clozapine Clozapine The metabolism of Zanubrutinib can be decreased when combined with Clozapine.
Clarithromycin Clarithromycin The metabolism of Zanubrutinib can be decreased when combined with Clarithromycin.
Felodipine Felodipine The metabolism of Zanubrutinib can be decreased when combined with Felodipine.
Simvastatin Simvastatin The metabolism of Zanubrutinib can be decreased when combined with Simvastatin.
Epoetin Alfa, Injection Epoetin Alfa, Injection The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Zanubrutinib.
Teniposide Injection Teniposide Injection The metabolism of Zanubrutinib can be decreased when combined with Teniposide.
Itraconazole Itraconazole The metabolism of Zanubrutinib can be decreased when combined with Itraconazole.
Rifabutin Rifabutin The metabolism of Zanubrutinib can be increased when combined with Rifabutin.
Doxazosin Doxazosin The metabolism of Zanubrutinib can be decreased when combined with Doxazosin.
Isradipine Isradipine The metabolism of Zanubrutinib can be decreased when combined with Isradipine.
Omeprazole Omeprazole The metabolism of Zanubrutinib can be increased when combined with Omeprazole.
Cisapride Cisapride The metabolism of Zanubrutinib can be decreased when combined with Cisapride.
Fluvastatin Fluvastatin The metabolism of Zanubrutinib can be decreased when combined with Fluvastatin.
Famciclovir Famciclovir The metabolism of Zanubrutinib can be decreased when combined with Famciclovir.
Fluvoxamine Fluvoxamine The metabolism of Zanubrutinib can be decreased when combined with Fluvoxamine.
Nefazodone Nefazodone The metabolism of Zanubrutinib can be decreased when combined with Nefazodone.
Losartan Losartan The metabolism of Zanubrutinib can be decreased when combined with Losartan.
Tramadol Tramadol The metabolism of Zanubrutinib can be decreased when combined with Tramadol.
Lansoprazole Lansoprazole The metabolism of Zanubrutinib can be increased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The metabolism of Zanubrutinib can be increased when combined with Ifosfamide.
Nicardipine Nicardipine The metabolism of Zanubrutinib can be decreased when combined with Nicardipine.
Bupropion Bupropion The metabolism of Zanubrutinib can be decreased when combined with Bupropion.
Ticlopidine Ticlopidine The metabolism of Zanubrutinib can be decreased when combined with Ticlopidine.
Saquinavir Saquinavir The metabolism of Zanubrutinib can be decreased when combined with Saquinavir.
Ritonavir Ritonavir The metabolism of Zanubrutinib can be decreased when combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Zanubrutinib can be decreased when combined with Docetaxel.
Clomipramine Clomipramine The metabolism of Zanubrutinib can be decreased when combined with Clomipramine.
Zafirlukast Zafirlukast The metabolism of Zanubrutinib can be decreased when combined with Zafirlukast.
Mirtazapine Mirtazapine The metabolism of Zanubrutinib can be decreased when combined with Mirtazapine.
Topiramate Topiramate The metabolism of Zanubrutinib can be increased when combined with Topiramate.
Nelfinavir Nelfinavir The metabolism of Zanubrutinib can be decreased when combined with Nelfinavir.
Azithromycin Azithromycin The metabolism of Zanubrutinib can be decreased when combined with Azithromycin.
Selegiline Selegiline The metabolism of Zanubrutinib can be decreased when combined with Selegiline.
Bicalutamide Bicalutamide The metabolism of Zanubrutinib can be decreased when combined with Bicalutamide.
Sertraline Sertraline The metabolism of Zanubrutinib can be decreased when combined with Sertraline.
Raloxifene Raloxifene The metabolism of Zanubrutinib can be decreased when combined with Raloxifene.
Irbesartan Irbesartan The metabolism of Zanubrutinib can be decreased when combined with Irbesartan.
Paroxetine Paroxetine The metabolism of Zanubrutinib can be decreased when combined with Paroxetine.
Citalopram Citalopram The metabolism of Zanubrutinib can be decreased when combined with Citalopram.
Efavirenz Efavirenz The metabolism of Zanubrutinib can be increased when combined with Efavirenz.
Rabeprazole Rabeprazole The metabolism of Zanubrutinib can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Zanubrutinib can be increased when combined with Terbinafine.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists