Palbociclib
Generic name: Pronounced as (pal'' boe sye' klib)
Medical Content Reviewed By HelloPharmacist Staff
Last Revised - 06/15/2019
On this page
- Why is this medication prescribed?
- How should this medicine be used?
- Other uses for this medicine
- What special precautions should I follow?
- What special dietary instructions should I follow?
- What should I do if I forget a dose?
- What side effects can this medication cause?
- What should I know about STORAGE and DISPOSAL of this medication?
- What should I do in case of OVERDOSE?
- What OTHER INFORMATION should I know?
- Drug interactions
Notice:
[Posted 09/13/2019]
AUDIENCE: Patient, Health Professional, Oncology
ISSUE: FDA is warning that palbociclib (Ibrance®), ribociclib (Kisqali®), and abemaciclib (Verzenio®) used to treat some patients with advanced breast cancers may cause rare but severe inflammation of the lungs. FDA has approved new warnings about this risk to the prescribing information and Patient Package Insert for the entire class of these cyclin-dependent kinase 4/6 (CDK 4/6) inhibitor medicines. The overall benefit of CDK 4/6 inhibitors is still greater than the risks when used as prescribed.
BACKGROUND: CDK 4/6 inhibitors are a class of prescription medicines that are used in combination with hormone therapies to treat adults with hormone receptor (HR)-positive, human epidermal growth factor 2 (HER2)-negative advanced or metastatic breast cancer that has spread to other parts of the body. CDK 4/6 inhibitors block certain molecules involved in promoting the growth of cancer cells. FDA approved palbociclib in 2015, and both ribociclib and abemaciclib in 2017. CDK 4/6 inhibitors have been shown to improve the amount of time after the start of treatment the cancer does not grow substantially and the patient is alive, called progression-free survival (See List of FDA-Approved CDK 4/6 Inhibitors below).
RECOMMENDATION: Patients should notify your health care professional right away if you have any new or worsening symptoms involving your lungs, as they may indicate a rare but life-threatening condition that can lead to death. Symptoms to watch for include:
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Difficulty or discomfort with breathing
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Shortness of breath while at rest or with low activity
Do not stop taking your medicine without first talking to your health care professional. All medicines have side effects even when used correctly as prescribed, but in general the benefits of taking these medicines outweigh these risks. It is important to know that people respond differently to all medicines depending on their health, the diseases they have, genetic factors, other medicines they are taking, and many other factors. Specific risk factors to determine how likely it is that a particular person will experience severe lung inflammation when taking palbociclib, ribociclib, or abemaciclib have not been identified.
Health care professionals should monitor patients regularly for pulmonary symptoms indicative of interstitial lung disease (ILD) and/or pneumonitis. Signs and symptoms may include:
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hypoxia
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cough
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dyspnea
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interstitial infiltrates on radiologic exams in patients in whom infectious, neoplastic, and other causes have been excluded.
Interrupt CDK 4/6 inhibitor treatment in patients who have new or worsening respiratory symptoms, and permanently discontinue treatment in patients with severe ILD and/or pneumonitis.
For more information visit the FDA website at: http://www.fda.gov/Safety/MedWatch/SafetyInformation and http://www.fda.gov/Drugs/DrugSafety.
Why is this medication prescribed?
Palbociclib is used in combination with anastrozole (Arimidex), exemestane (Aromasin), or letrozole (Femara) to treat a certain type of hormone receptor–positive, advanced breast cancer (breast cancer that depends on hormones such as estrogen to grow) or breast cancer that has spread to other parts of the body in women who have experienced menopause (change of life; end of monthly menstrual periods) or in men. Palbociclib is also used along with fulvestrant (Faslodex) to treat a certain type of hormone receptor–positive, advanced breast cancer (breast cancer that depends on hormones such as estrogen to grow) or breast cancer that has spread to other parts of the body in people who have been treated with an antiestrogen medication such as tamoxifen (Nolvadex). Palbociclib is in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps stop or slow the spread of cancer cells.
How should this medicine be used?
Palbociclib comes as a capsule to take by mouth. It is usually taken with food once daily for the first 21 days of a 28-day cycle. Your doctor will decide how many times you should repeat this cycle. Take palbociclib at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take palbociclib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Swallow the capsules whole; do not open, chew, or crush them. Do not take capsules that are broken or cracked.
If you vomit after taking palbociclib, do not take another dose. Continue your regular dosing schedule.
Your doctor may decrease your dose or temporarily or permanently stop your treatment if you experience certain side effects. Be sure to tell your doctor how you are feeling during your treatment with palbociclib.
Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.
Other uses for this medicine
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What special precautions should I follow?
Before taking palbociclib,
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tell your doctor and pharmacist if you are allergic to palbociclib, any other medications, or any of the ingredients in palbociclib capsules. Ask your pharmacist for a list of the ingredients.
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tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antifungals such as itraconazole (Onmel, Sporanox, Tolsura), ketoconazole, posaconazole (Noxafil), and voriconazole (Vfend); certain medications to treat seizures such as carbamazepine (Carbatrol, Equetro, Epitol, Tegretol, others) and phenytoin (Dilantin, Phenytek); clarithromycin; enzalutamide (Xtandi); ergot alkaloids such as dihydroergotamine (D.H.E 45, Migranal) and ergotamine (Ergomar, in Cafergot, in Migergot); certain medications for human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) including indinavir (Crixivan), lopinavir (in Kaletra), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra, in Viekira Pak), saquinavir (Invirase), and telaprevir (no longer available in the U.S.); fentanyl (Abstral, Fentora, Lazanda, Subsys, others); immunosuppressants such as cyclosporine (Gengraf, Neoral, Sandimmune), everolimus (Afinitor, Zortress), sirolimus (Rapamune), and tacrolimus (Astagraf XL, Envarsus XR, Prograf); midazolam; nefazodone; pimozide (Orap); quinidine (in Nuedexta); rifampin (Rimactane, Rifadin, in Rifater, in Rifamate); and telithromycin (Ketek). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with palbociclib, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
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tell your doctor and pharmacist what herbal products you are taking, especially St. John's wort.
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tell your doctor if you have an infection or if you have or have ever had liver or kidney disease.
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tell your doctor if you are pregnant, plan to become pregnant, or if you plan on fathering a child. If you are female, you will need to take a pregnancy test before you start treatment and use birth control to prevent pregnancy during your treatment and for at least 3 weeks after your final dose. If you are a male, you and your partner should use birth control during your treatment with palbociclib and for 3 months after your final dose. Talk to your doctor about birth control methods that you can use during your treatment. If you or your partner become pregnant while taking palbociclib, call your doctor immediately. Palbociclib may harm the fetus.
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tell your doctor if you are breastfeeding. You should not breastfeed while you are taking palbociclib and for 3 weeks after the final dose.
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if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking palbociclib.
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you should know that this medication may decrease fertility in men. Talk to your doctor about the risks of taking palbociclib.
What special dietary instructions should I follow?
Do not eat grapefruit or drink grapefruit juice while taking this medication.
What should I do if I forget a dose?
Skip the missed dose and continue your regular dosing schedule. Do not take a double dose on the same day to make up for a missed one.
What side effects can this medication cause?
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Palbociclib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
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nausea
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diarrhea
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vomiting
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decreased appetite
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changes in taste
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tiredness
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numbness or tingling in your arms, hands, legs, and feet
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sores on the lips, mouth, or throat
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unusual hair thinning or hair loss
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dry skin
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rash
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Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:
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fever, chills, or signs of infection
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shortness of breath
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dizziness
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fast, irregular, or pounding heartbeat
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weakness
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unusual bleeding or bruising
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nosebleeds
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Palbociclib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
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If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
What should I know about STORAGE and DISPOSAL of this medication?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.
It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org
What should I do in case of OVERDOSE?
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
What OTHER INFORMATION should I know?
Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests before and during your treatment to check your body's response to palbociclib.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Drug interactions
Drug | Interaction |
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Leflunomide | Leflunomide The risk or severity of adverse effects can be increased when Palbociclib is combined with Leflunomide. |
Delavirdine | Delavirdine The metabolism of Palbociclib can be decreased when combined with Delavirdine. |
Atorvastatin | Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Palbociclib. |
Aminophylline | Aminophylline The metabolism of Aminophylline can be decreased when combined with Palbociclib. |
Anagrelide | Anagrelide The risk or severity of bleeding can be increased when Anagrelide is combined with Palbociclib. |
Calcium Carbonate | Calcium Carbonate The absorption of Palbociclib can be decreased when combined with Calcium carbonate. |
Cilostazol | Cilostazol The metabolism of Cilostazol can be decreased when combined with Palbociclib. |
Clopidogrel | Clopidogrel The risk or severity of bleeding can be increased when Clopidogrel is combined with Palbociclib. |
Erythromycin and Sulfisoxazole | Erythromycin and Sulfisoxazole The metabolism of Palbociclib can be decreased when combined with Erythromycin. |
Estrogen and Progestin (Oral Contraceptives) | Estrogen and Progestin (Oral Contraceptives) Palbociclib may decrease the excretion rate of Conjugated estrogens which could result in a higher serum level. |
Fenofibrate | Fenofibrate The metabolism of Fenofibrate can be decreased when combined with Palbociclib. |
Guanfacine | Guanfacine The risk or severity of adverse effects can be increased when Palbociclib is combined with Guanfacine. |
Magnesium Hydroxide | Magnesium Hydroxide The absorption of Palbociclib can be decreased when combined with Magnesium hydroxide. |
Magnesium Oxide | Magnesium Oxide The absorption of Palbociclib can be decreased when combined with Magnesium oxide. |
Methylergonovine | Methylergonovine The metabolism of Palbociclib can be decreased when combined with Methylergometrine. |
Mycophenolate | Mycophenolate The risk or severity of adverse effects can be increased when Mycophenolic acid is combined with Palbociclib. |
Paregoric | Paregoric The serum concentration of Morphine can be increased when it is combined with Palbociclib. |
Prednisone | Prednisone The risk or severity of adverse effects can be increased when Prednisone is combined with Palbociclib. |
Ranitidine | Ranitidine The absorption of Palbociclib can be decreased when combined with Ranitidine. |
Sumatriptan | Sumatriptan Palbociclib may decrease the excretion rate of Sumatriptan which could result in a higher serum level. |
Tacrolimus | Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Palbociclib. |
Triamcinolone | Triamcinolone The metabolism of Palbociclib can be increased when combined with Triamcinolone. |
Doxycycline Injection | Doxycycline Injection The metabolism of Palbociclib can be decreased when combined with Doxycycline. |
Famotidine Injection | Famotidine Injection The absorption of Palbociclib can be decreased when combined with Famotidine. |
Fluconazole Injection | Fluconazole Injection The metabolism of Palbociclib can be decreased when combined with Fluconazole. |
Interferon Beta-1b Injection | Interferon Beta-1b Injection The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Palbociclib. |
Interferon Gamma-1b Injection | Interferon Gamma-1b Injection The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Palbociclib. |
Meperidine Injection | Meperidine Injection The metabolism of Meperidine can be increased when combined with Palbociclib. |
Methylprednisolone Injection | Methylprednisolone Injection The metabolism of Palbociclib can be increased when combined with Methylprednisolone. |
Metronidazole Injection | Metronidazole Injection The metabolism of Palbociclib can be decreased when combined with Metronidazole. |
Morphine Injection | Morphine Injection The serum concentration of Morphine can be increased when it is combined with Palbociclib. |
Zidovudine Injection | Zidovudine Injection The risk or severity of adverse effects can be increased when Zidovudine is combined with Palbociclib. |
Cyclosporine | Cyclosporine Palbociclib may increase the immunosuppressive activities of Cyclosporine. |
Enoxaparin Injection | Enoxaparin Injection The risk or severity of bleeding can be increased when Enoxaparin is combined with Palbociclib. |
Dofetilide | Dofetilide The metabolism of Dofetilide can be decreased when combined with Palbociclib. |
Hydroxychloroquine | Hydroxychloroquine The risk or severity of adverse effects can be increased when Hydroxychloroquine is combined with Palbociclib. |
Orlistat | Orlistat The metabolism of Palbociclib can be increased when combined with Orlistat. |
Oxcarbazepine | Oxcarbazepine The metabolism of Palbociclib can be increased when combined with Oxcarbazepine. |
Pantoprazole | Pantoprazole The absorption of Palbociclib can be decreased when combined with Pantoprazole. |
Telmisartan | Telmisartan Telmisartan may decrease the excretion rate of Palbociclib which could result in a higher serum level. |
Temozolomide | Temozolomide The risk or severity of adverse effects can be increased when Temozolomide is combined with Palbociclib. |
Anakinra | Anakinra The metabolism of Palbociclib can be increased when combined with Anakinra. |
Linezolid | Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Palbociclib. |
Pentosan Polysulfate | Pentosan Polysulfate The risk or severity of bleeding can be increased when Pentosan polysulfate is combined with Palbociclib. |
Trimipramine | Trimipramine The serum concentration of Trimipramine can be increased when it is combined with Palbociclib. |
Etanercept Injection | Etanercept Injection The metabolism of Palbociclib can be increased when combined with Etanercept. |
Modafinil | Modafinil The metabolism of Palbociclib can be increased when combined with Modafinil. |
Tenofovir | Tenofovir The metabolism of Tenofovir can be decreased when combined with Palbociclib. |
Sirolimus | Sirolimus The serum concentration of Sirolimus can be increased when it is combined with Palbociclib. |
Epinephrine Injection | Epinephrine Injection The metabolism of Epinephrine can be decreased when combined with Palbociclib. |
Epirubicin | Epirubicin The risk or severity of adverse effects can be increased when Epirubicin is combined with Palbociclib. |
Adalimumab Injection | Adalimumab Injection The metabolism of Palbociclib can be increased when combined with Adalimumab. |
Aripiprazole | Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Palbociclib. |
Ezetimibe | Ezetimibe Palbociclib may decrease the excretion rate of Ezetimibe which could result in a higher serum level. |
Glatiramer Injection | Glatiramer Injection The risk or severity of adverse effects can be increased when Glatiramer is combined with Palbociclib. |
Atazanavir | Atazanavir The metabolism of Palbociclib can be decreased when combined with Atazanavir. |
Mefloquine | Mefloquine The metabolism of Palbociclib can be decreased when combined with Mefloquine. |
Rosuvastatin | Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Palbociclib. |
Vardenafil | Vardenafil The metabolism of Vardenafil can be decreased when combined with Palbociclib. |
Alfuzosin | Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Palbociclib. |
Aprepitant | Aprepitant The metabolism of Palbociclib can be decreased when combined with Aprepitant. |
Tegaserod | Tegaserod Palbociclib may decrease the excretion rate of Tegaserod which could result in a higher serum level. |
Progesterone | Progesterone The metabolism of Palbociclib can be increased when combined with Progesterone. |
Darbepoetin Alfa Injection | Darbepoetin Alfa Injection The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Palbociclib. |
Infliximab Injection | Infliximab Injection The metabolism of Palbociclib can be increased when combined with Infliximab. |
Rifaximin | Rifaximin The serum concentration of Rifaximin can be increased when it is combined with Palbociclib. |
Duloxetine | Duloxetine The metabolism of Duloxetine can be decreased when combined with Palbociclib. |
Norethindrone | Norethindrone The metabolism of Palbociclib can be decreased when combined with Norethisterone. |
Bosentan | Bosentan The metabolism of Palbociclib can be increased when combined with Bosentan. |
Natalizumab Injection | Natalizumab Injection The risk or severity of adverse effects can be increased when Palbociclib is combined with Natalizumab. |
Erlotinib | Erlotinib The metabolism of Palbociclib can be decreased when combined with Erlotinib. |
Eszopiclone | Eszopiclone The metabolism of Eszopiclone can be decreased when combined with Palbociclib. |
Ganciclovir | Ganciclovir The risk or severity of adverse effects can be increased when Palbociclib is combined with Ganciclovir. |
Palifermin | Palifermin The therapeutic efficacy of Palifermin can be decreased when used in combination with Palbociclib. |
Voriconazole | Voriconazole The metabolism of Palbociclib can be decreased when combined with Voriconazole. |
Peginterferon Alfa-2a Injection | Peginterferon Alfa-2a Injection The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Palbociclib. |
Peginterferon Alfa-2b (PEG-Intron) | Peginterferon Alfa-2b (PEG-Intron) The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Palbociclib. |
Fentanyl | Fentanyl The metabolism of Fentanyl can be decreased when combined with Palbociclib. |
Deferasirox | Deferasirox The metabolism of Palbociclib can be increased when combined with Deferasirox. |
Tipranavir | Tipranavir The metabolism of Tipranavir can be decreased when combined with Palbociclib. |
Felbamate | Felbamate The metabolism of Palbociclib can be increased when combined with Felbamate. |
Ranolazine | Ranolazine The serum concentration of Ranolazine can be increased when it is combined with Palbociclib. |
Abatacept Injection | Abatacept Injection The metabolism of Palbociclib can be increased when combined with Abatacept. |
Imatinib | Imatinib The metabolism of Palbociclib can be decreased when combined with Imatinib. |
Sitagliptin | Sitagliptin The serum concentration of Sitagliptin can be increased when it is combined with Palbociclib. |
Bevacizumab Injection | Bevacizumab Injection The risk or severity of adverse effects can be increased when Bevacizumab is combined with Palbociclib. |
Gefitinib | Gefitinib The metabolism of Palbociclib can be decreased when combined with Gefitinib. |
Paliperidone | Paliperidone The serum concentration of Palbociclib can be increased when it is combined with Paliperidone. |
Bortezomib | Bortezomib The metabolism of Palbociclib can be decreased when combined with Bortezomib. |
Clofarabine Injection | Clofarabine Injection The risk or severity of adverse effects can be increased when Clofarabine is combined with Palbociclib. |
Hepatitis B Vaccine | Hepatitis B Vaccine The therapeutic efficacy of Hepatitis B Vaccine (Recombinant) can be decreased when used in combination with Palbociclib. |
Influenza Vaccine, Inactivated or Recombinant | Influenza Vaccine, Inactivated or Recombinant The therapeutic efficacy of Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Palbociclib. |
Influenza Vaccine, Live Intranasal | Influenza Vaccine, Live Intranasal The risk or severity of infection can be increased when Typhoid Vaccine Live is combined with Palbociclib. |
Live Shingles (Zoster) Vaccine (ZVL) | Live Shingles (Zoster) Vaccine (ZVL) The risk or severity of infection can be increased when Varicella Zoster Vaccine (Live/attenuated) is combined with Palbociclib. |
Oxaliplatin Injection | Oxaliplatin Injection The risk or severity of adverse effects can be increased when Oxaliplatin is combined with Palbociclib. |
Posaconazole | Posaconazole The metabolism of Palbociclib can be decreased when combined with Posaconazole. |
Primaquine | Primaquine The metabolism of Palbociclib can be decreased when combined with Primaquine. |
Rituximab Injection | Rituximab Injection The risk or severity of adverse effects can be increased when Rituximab is combined with Palbociclib. |
Darunavir | Darunavir The serum concentration of Darunavir can be increased when it is combined with Palbociclib. |
Pemetrexed Injection | Pemetrexed Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Palbociclib. |
Retapamulin | Retapamulin The metabolism of Retapamulin can be decreased when combined with Palbociclib. |
Vorinostat | Vorinostat The risk or severity of adverse effects can be increased when Vorinostat is combined with Palbociclib. |
Sorafenib | Sorafenib The metabolism of Palbociclib can be decreased when combined with Sorafenib. |
Sunitinib | Sunitinib The metabolism of Palbociclib can be decreased when combined with Sunitinib. |
Dronabinol | Dronabinol Dronabinol may decrease the excretion rate of Palbociclib which could result in a higher serum level. |
Lapatinib | Lapatinib The metabolism of Palbociclib can be decreased when combined with Lapatinib. |
Dasatinib | Dasatinib The metabolism of Dasatinib can be decreased when combined with Palbociclib. |
Armodafinil | Armodafinil The metabolism of Palbociclib can be increased when combined with Armodafinil. |
Azacitidine Injection | Azacitidine Injection The risk or severity of adverse effects can be increased when Azacitidine is combined with Palbociclib. |
Ivermectin | Ivermectin The metabolism of Ivermectin can be increased when combined with Palbociclib. |
Temsirolimus | Temsirolimus The serum concentration of Temsirolimus can be increased when it is combined with Palbociclib. |
Nelarabine Injection | Nelarabine Injection The risk or severity of adverse effects can be increased when Nelarabine is combined with Palbociclib. |
Lenalidomide | Lenalidomide The risk or severity of adverse effects can be increased when Lenalidomide is combined with Palbociclib. |
Nilotinib | Nilotinib The metabolism of Palbociclib can be decreased when combined with Nilotinib. |
Toremifene | Toremifene The serum concentration of Palbociclib can be increased when it is combined with Toremifene. |
Bexarotene | Bexarotene The metabolism of Palbociclib can be increased when combined with Bexarotene. |
Budesonide | Budesonide The metabolism of Palbociclib can be increased when combined with Budesonide. |
Chloramphenicol Injection | Chloramphenicol Injection The metabolism of Palbociclib can be decreased when combined with Chloramphenicol. |
Decitabine Injection | Decitabine Injection The risk or severity of adverse effects can be increased when Decitabine is combined with Palbociclib. |
Etravirine | Etravirine The metabolism of Palbociclib can be increased when combined with Etravirine. |
Arsenic Trioxide Injection | Arsenic Trioxide Injection The risk or severity of adverse effects can be increased when Arsenic trioxide is combined with Palbociclib. |
Mitoxantrone Injection | Mitoxantrone Injection The metabolism of Palbociclib can be decreased when combined with Mitoxantrone. |
Desvenlafaxine | Desvenlafaxine The metabolism of Palbociclib can be decreased when combined with Desvenlafaxine. |
Tretinoin | Tretinoin The risk or severity of adverse effects can be increased when Tretinoin is combined with Palbociclib. |
Bendamustine Injection | Bendamustine Injection The serum concentration of Palbociclib can be increased when it is combined with Bendamustine. |
Pilocarpine | Pilocarpine The metabolism of Palbociclib can be decreased when combined with Pilocarpine. |
Certolizumab Injection | Certolizumab Injection The metabolism of Palbociclib can be increased when combined with Certolizumab pegol. |
Ixabepilone Injection | Ixabepilone Injection The metabolism of Palbociclib can be decreased when combined with Ixabepilone. |
Irinotecan Injection | Irinotecan Injection The metabolism of Palbociclib can be decreased when combined with Irinotecan. |
Estramustine | Estramustine The risk or severity of adverse effects can be increased when Estramustine is combined with Palbociclib. |
Mitotane | Mitotane The metabolism of Palbociclib can be increased when combined with Mitotane. |
Alemtuzumab Injection (Chronic Lymphocytic Leukemia) | Alemtuzumab Injection (Chronic Lymphocytic Leukemia) The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Palbociclib. |
Rufinamide | Rufinamide The metabolism of Rufinamide can be increased when combined with Palbociclib. |
Silodosin | Silodosin The serum concentration of Silodosin can be increased when it is combined with Palbociclib. |
Midazolam | Midazolam The serum concentration of Midazolam can be increased when it is combined with Palbociclib. |
Dexrazoxane Injection | Dexrazoxane Injection The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Palbociclib. |
Eltrombopag | Eltrombopag Eltrombopag may decrease the excretion rate of Palbociclib which could result in a higher serum level. |
Ibritumomab Injection | Ibritumomab Injection The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Palbociclib. |
Milnacipran | Milnacipran The metabolism of Palbociclib can be decreased when combined with Milnacipran. |
Dexlansoprazole | Dexlansoprazole The absorption of Palbociclib can be decreased when combined with Dexlansoprazole. |
Iloperidone | Iloperidone The metabolism of Iloperidone can be decreased when combined with Palbociclib. |
Prasugrel | Prasugrel The risk or severity of bleeding can be increased when Prasugrel is combined with Palbociclib. |
Lacosamide | Lacosamide The metabolism of Palbociclib can be decreased when combined with Lacosamide. |
Everolimus | Everolimus The serum concentration of Everolimus can be increased when it is combined with Palbociclib. |
Tolvaptan (low blood sodium) | Tolvaptan (low blood sodium) The serum concentration of Tolvaptan can be increased when it is combined with Palbociclib. |
Dronedarone | Dronedarone The serum concentration of Dronedarone can be increased when it is combined with Palbociclib. |
Pralatrexate Injection | Pralatrexate Injection The risk or severity of adverse effects can be increased when Pralatrexate is combined with Palbociclib. |
Romidepsin Injection | Romidepsin Injection The serum concentration of Romidepsin can be increased when it is combined with Palbociclib. |
Topotecan | Topotecan The serum concentration of Topotecan can be increased when it is combined with Palbociclib. |
Golimumab Injection | Golimumab Injection The metabolism of Palbociclib can be increased when combined with Golimumab. |
Pazopanib | Pazopanib The serum concentration of Pazopanib can be increased when it is combined with Palbociclib. |
Pitavastatin | Pitavastatin Palbociclib may decrease the excretion rate of Pitavastatin which could result in a higher serum level. |
Albendazole | Albendazole The metabolism of Albendazole can be decreased when combined with Palbociclib. |
Denosumab Injection | Denosumab Injection The risk or severity of adverse effects can be increased when Denosumab is combined with Palbociclib. |
Dabigatran | Dabigatran The risk or severity of bleeding can be increased when Dabigatran is combined with Palbociclib. |
Tocilizumab Injection | Tocilizumab Injection The metabolism of Palbociclib can be increased when combined with Tocilizumab. |
Fingolimod | Fingolimod Palbociclib may increase the immunosuppressive activities of Fingolimod. |
Eribulin Injection | Eribulin Injection The risk or severity of adverse effects can be increased when Eribulin is combined with Palbociclib. |
Cabazitaxel Injection | Cabazitaxel Injection The serum concentration of Palbociclib can be increased when it is combined with Cabazitaxel. |
Acetaminophen Injection | Acetaminophen Injection The metabolism of Palbociclib can be increased when combined with Acetaminophen. |
Denileukin Diftitox Injection | Denileukin Diftitox Injection The metabolism of Palbociclib can be decreased when combined with Aldesleukin. |
Sipuleucel-T Injection | Sipuleucel-T Injection The therapeutic efficacy of Sipuleucel-T can be decreased when used in combination with Palbociclib. |
Belimumab Injection | Belimumab Injection The risk or severity of adverse effects can be increased when Belimumab is combined with Palbociclib. |
Busulfan Injection | Busulfan Injection The metabolism of Palbociclib can be decreased when combined with Busulfan. |
Roflumilast | Roflumilast Roflumilast may increase the immunosuppressive activities of Palbociclib. |
Linagliptin | Linagliptin The metabolism of Palbociclib can be decreased when combined with Linagliptin. |
Rilpivirine | Rilpivirine The metabolism of Palbociclib can be decreased when combined with Rilpivirine. |
Telaprevir | Telaprevir The metabolism of Glecaprevir can be decreased when combined with Palbociclib. |
Cyclophosphamide Injection | Cyclophosphamide Injection The metabolism of Palbociclib can be increased when combined with Cyclophosphamide. |
Rivaroxaban | Rivaroxaban Palbociclib may decrease the excretion rate of Rivaroxaban which could result in a higher serum level. |
Ticagrelor | Ticagrelor The metabolism of Ticagrelor can be decreased when combined with Palbociclib. |
Brentuximab Vedotin Injection | Brentuximab Vedotin Injection The serum concentration of Brentuximab vedotin can be increased when it is combined with Palbociclib. |
Ruxolitinib | Ruxolitinib The metabolism of Palbociclib can be decreased when combined with Ruxolitinib. |
Vandetanib | Vandetanib The metabolism of Palbociclib can be decreased when combined with Vandetanib. |
Clobazam | Clobazam The metabolism of Clobazam can be increased when combined with Palbociclib. |
Vemurafenib | Vemurafenib The metabolism of Palbociclib can be decreased when combined with Vemurafenib. |
Vismodegib | Vismodegib Vismodegib may decrease the excretion rate of Palbociclib which could result in a higher serum level. |
Belatacept Injection | Belatacept Injection The risk or severity of adverse effects can be increased when Belatacept is combined with Palbociclib. |
Ivacaftor | Ivacaftor The metabolism of Palbociclib can be decreased when combined with Ivacaftor. |
Basiliximab Injection | Basiliximab Injection The risk or severity of adverse effects can be increased when Basiliximab is combined with Palbociclib. |
Axitinib | Axitinib The metabolism of Axitinib can be decreased when combined with Palbociclib. |
Crizotinib | Crizotinib The metabolism of Palbociclib can be decreased when combined with Crizotinib. |
Melphalan Injection | Melphalan Injection The risk or severity of adverse effects can be increased when Melphalan is combined with Palbociclib. |
Cabergoline | Cabergoline The metabolism of Cabergoline can be decreased when combined with Palbociclib. |
Naloxone Injection | Naloxone Injection The metabolism of Palbociclib can be decreased when combined with Naloxone. |
Ambrisentan | Ambrisentan The serum concentration of Ambrisentan can be increased when it is combined with Palbociclib. |
Eculizumab Injection | Eculizumab Injection The risk or severity of adverse effects can be increased when Eculizumab is combined with Palbociclib. |
Fondaparinux Injection | Fondaparinux Injection The risk or severity of bleeding can be increased when Fondaparinux is combined with Palbociclib. |
Carfilzomib Injection | Carfilzomib Injection The serum concentration of Palbociclib can be increased when it is combined with Carfilzomib. |
Iloprost | Iloprost The risk or severity of bleeding can be increased when Iloprost is combined with Palbociclib. |
Enzalutamide | Enzalutamide The metabolism of Palbociclib can be increased when combined with Enzalutamide. |
Mirabegron | Mirabegron The serum concentration of Palbociclib can be increased when it is combined with Mirabegron. |
Regorafenib | Regorafenib The metabolism of Palbociclib can be decreased when combined with Regorafenib. |
Bosutinib | Bosutinib The serum concentration of Bosutinib can be increased when it is combined with Palbociclib. |
Corticotropin, Repository Injection | Corticotropin, Repository Injection The metabolism of Palbociclib can be increased when combined with Corticotropin. |
Teriflunomide | Teriflunomide The risk or severity of adverse effects can be increased when Teriflunomide is combined with Palbociclib. |
Icosapent Ethyl | Icosapent Ethyl The risk or severity of bleeding can be increased when Icosapent ethyl is combined with Palbociclib. |
Tofacitinib | Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Palbociclib. |
Dimethyl Fumarate | Dimethyl Fumarate The risk or severity of adverse effects can be increased when Dimethyl fumarate is combined with Palbociclib. |
Ponatinib | Ponatinib The metabolism of Palbociclib can be decreased when combined with Ponatinib. |
Pomalidomide | Pomalidomide The serum concentration of Palbociclib can be increased when it is combined with Pomalidomide. |
Ado-trastuzumab Emtansine Injection | Ado-trastuzumab Emtansine Injection The serum concentration of Palbociclib can be increased when it is combined with Trastuzumab emtansine. |
Apixaban | Apixaban Palbociclib may decrease the excretion rate of Apixaban which could result in a higher serum level. |
Canagliflozin | Canagliflozin The serum concentration of Palbociclib can be increased when it is combined with Canagliflozin. |
Dabrafenib | Dabrafenib The serum concentration of Dabrafenib can be increased when it is combined with Palbociclib. |
Trametinib | Trametinib The metabolism of Palbociclib can be increased when combined with Trametinib. |
Dolutegravir | Dolutegravir Palbociclib may decrease the excretion rate of Dolutegravir which could result in a higher serum level. |
Afatinib | Afatinib The serum concentration of Afatinib can be increased when it is combined with Palbociclib. |
Perampanel | Perampanel The metabolism of Palbociclib can be increased when combined with Perampanel. |
Ibrutinib | Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Palbociclib. |
Lomitapide | Lomitapide The metabolism of Lomitapide can be decreased when combined with Palbociclib. |
Obinutuzumab Injection | Obinutuzumab Injection The risk or severity of adverse effects can be increased when Obinutuzumab is combined with Palbociclib. |
Simeprevir | Simeprevir The metabolism of Palbociclib can be decreased when combined with Simeprevir. |
Sofosbuvir | Sofosbuvir Palbociclib may decrease the excretion rate of Sofosbuvir which could result in a higher serum level. |
Apremilast | Apremilast The metabolism of Palbociclib can be increased when combined with Apremilast. |
Ceritinib | Ceritinib The serum concentration of Ceritinib can be increased when it is combined with Palbociclib. |
Siltuximab Injection | Siltuximab Injection The metabolism of Palbociclib can be increased when combined with Siltuximab. |
Eslicarbazepine | Eslicarbazepine The metabolism of Palbociclib can be increased when combined with Eslicarbazepine. |
Vedolizumab Injection | Vedolizumab Injection The risk or severity of adverse effects can be increased when Vedolizumab is combined with Palbociclib. |
Belinostat Injection | Belinostat Injection The risk or severity of adverse effects can be increased when Belinostat is combined with Palbociclib. |
Idelalisib | Idelalisib The metabolism of Idelalisib can be decreased when combined with Palbociclib. |
Testosterone Injection | Testosterone Injection The metabolism of Testosterone can be increased when combined with Palbociclib. |
Oritavancin Injection | Oritavancin Injection The metabolism of Palbociclib can be increased when combined with Oritavancin. |
Vorapaxar | Vorapaxar The metabolism of Vorapaxar can be decreased when combined with Palbociclib. |
Suvorexant | Suvorexant The metabolism of Suvorexant can be decreased when combined with Palbociclib. |
Edoxaban | Edoxaban The serum concentration of Edoxaban can be increased when it is combined with Palbociclib. |
Peginterferon Beta-1a Injection | Peginterferon Beta-1a Injection The risk or severity of adverse effects can be increased when Palbociclib is combined with Peginterferon beta-1a. |
Olaparib | Olaparib The metabolism of Olaparib can be decreased when combined with Palbociclib. |
Blinatumomab Injection | Blinatumomab Injection The risk or severity of adverse effects can be increased when Blinatumomab is combined with Palbociclib. |
Tasimelteon | Tasimelteon The metabolism of Palbociclib can be decreased when combined with Tasimelteon. |
Riociguat | Riociguat Palbociclib may decrease the excretion rate of Riociguat which could result in a higher serum level. |
Lanreotide Injection | Lanreotide Injection The metabolism of Palbociclib can be decreased when combined with Lanreotide. |
Pirfenidone | Pirfenidone The risk or severity of adverse effects can be increased when Pirfenidone is combined with Palbociclib. |
Nintedanib | Nintedanib The metabolism of Nintedanib can be decreased when combined with Palbociclib. |
Secukinumab Injection | Secukinumab Injection The metabolism of Palbociclib can be increased when combined with Secukinumab. |
Lenvatinib | Lenvatinib The metabolism of Lenvatinib can be increased when combined with Palbociclib. |
Naloxegol | Naloxegol The serum concentration of Naloxegol can be increased when it is combined with Palbociclib. |
Panobinostat | Panobinostat The metabolism of Palbociclib can be decreased when combined with Panobinostat. |
Dinutuximab Injection | Dinutuximab Injection The risk or severity of adverse effects can be increased when Palbociclib is combined with Dinutuximab. |
Haloperidol Injection | Haloperidol Injection The serum concentration of Haloperidol can be increased when it is combined with Palbociclib. |
Isavuconazonium Injection | Isavuconazonium Injection The metabolism of Palbociclib can be increased when combined with Isavuconazonium. |
Sonidegib | Sonidegib The metabolism of Sonidegib can be decreased when combined with Palbociclib. |
Rolapitant | Rolapitant Rolapitant may decrease the excretion rate of Palbociclib which could result in a higher serum level. |
Prednisolone | Prednisolone The metabolism of Palbociclib can be increased when combined with Prednisolone. |
Daclatasvir | Daclatasvir Daclatasvir may decrease the excretion rate of Palbociclib which could result in a higher serum level. |
Ziprasidone Injection | Ziprasidone Injection The metabolism of Ziprasidone can be decreased when combined with Palbociclib. |
Cobimetinib | Cobimetinib The serum concentration of Cobimetinib can be increased when it is combined with Palbociclib. |
Mepolizumab Injection | Mepolizumab Injection The risk or severity of adverse effects can be increased when Mepolizumab is combined with Palbociclib. |
Trabectedin Injection | Trabectedin Injection The metabolism of Palbociclib can be decreased when combined with Trabectedin. |
Osimertinib | Osimertinib The metabolism of Osimertinib can be increased when combined with Palbociclib. |
Alectinib | Alectinib The metabolism of Palbociclib can be decreased when combined with Alectinib. |
Ixazomib | Ixazomib The metabolism of Ixazomib can be decreased when combined with Palbociclib. |
Rifapentine | Rifapentine The metabolism of Palbociclib can be increased when combined with Rifapentine. |
Lesinurad | Lesinurad The metabolism of Palbociclib can be increased when combined with Lesinurad. |
Amphotericin B Liposomal Injection | Amphotericin B Liposomal Injection The metabolism of Palbociclib can be decreased when combined with Amphotericin B. |
Dexamethasone Injection | Dexamethasone Injection The metabolism of Palbociclib can be increased when combined with Dexamethasone. |
Defibrotide Injection | Defibrotide Injection The risk or severity of bleeding can be increased when Defibrotide is combined with Palbociclib. |
Ixekizumab Injection | Ixekizumab Injection The risk or severity of adverse effects can be increased when Palbociclib is combined with Ixekizumab. |
Venetoclax | Venetoclax The metabolism of Venetoclax can be decreased when combined with Palbociclib. |
Cobicistat | Cobicistat The metabolism of Palbociclib can be decreased when combined with Cobicistat. |
Selexipag | Selexipag The serum concentration of Selexipag can be increased when it is combined with Palbociclib. |
Rucaparib | Rucaparib The metabolism of Rucaparib can be decreased when combined with Palbociclib. |
Ribociclib | Ribociclib The metabolism of Palbociclib can be decreased when combined with Ribociclib. |
Brodalumab Injection | Brodalumab Injection The risk or severity of adverse effects can be increased when Palbociclib is combined with Brodalumab. |
Brigatinib | Brigatinib The metabolism of Brigatinib can be increased when combined with Palbociclib. |
Deflazacort | Deflazacort The metabolism of Deflazacort can be increased when combined with Palbociclib. |
Safinamide | Safinamide Safinamide may decrease the excretion rate of Palbociclib which could result in a higher serum level. |
Ocrelizumab Injection | Ocrelizumab Injection The risk or severity of adverse effects can be increased when Palbociclib is combined with Ocrelizumab. |
Sarilumab Injection | Sarilumab Injection The metabolism of Sarilumab can be increased when combined with Palbociclib. |
Midostaurin | Midostaurin The metabolism of Palbociclib can be decreased when combined with Midostaurin. |
Neratinib | Neratinib The metabolism of Neratinib can be decreased when combined with Palbociclib. |
Guselkumab Injection | Guselkumab Injection The risk or severity of adverse effects can be increased when Palbociclib is combined with Guselkumab. |
Enasidenib | Enasidenib The metabolism of Enasidenib can be decreased when combined with Palbociclib. |
Inotuzumab Ozogamicin Injection | Inotuzumab Ozogamicin Injection The serum concentration of Inotuzumab ozogamicin can be increased when it is combined with Palbociclib. |
Aprepitant/Fosaprepitant Injection | Aprepitant/Fosaprepitant Injection The metabolism of Fosaprepitant can be increased when combined with Palbociclib. |
Copanlisib Injection | Copanlisib Injection The serum concentration of Copanlisib can be increased when it is combined with Palbociclib. |
Delafloxacin | Delafloxacin Palbociclib may decrease the excretion rate of Delafloxacin which could result in a higher serum level. |
Abemaciclib | Abemaciclib The metabolism of Abemaciclib can be decreased when combined with Palbociclib. |
Betrixaban | Betrixaban The serum concentration of Betrixaban can be increased when it is combined with Palbociclib. |
Acalabrutinib | Acalabrutinib The metabolism of Acalabrutinib can be decreased when combined with Palbociclib. |
Gemtuzumab Ozogamicin Injection | Gemtuzumab Ozogamicin Injection The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Palbociclib. |
Letermovir | Letermovir The metabolism of Palbociclib can be decreased when combined with Letermovir. |
Ertugliflozin | Ertugliflozin Palbociclib may decrease the excretion rate of Ertugliflozin which could result in a higher serum level. |
Buprenorphine Injection | Buprenorphine Injection The metabolism of Palbociclib can be decreased when combined with Buprenorphine. |
Apalutamide | Apalutamide The metabolism of Palbociclib can be increased when combined with Apalutamide. |
Penicillamine | Penicillamine The risk or severity of adverse effects can be increased when Penicillamine is combined with Palbociclib. |
Fostamatinib | Fostamatinib The metabolism of Palbociclib can be decreased when combined with Fostamatinib. |
Avatrombopag | Avatrombopag Avatrombopag may decrease the excretion rate of Palbociclib which could result in a higher serum level. |
Baricitinib | Baricitinib The metabolism of Baricitinib can be decreased when combined with Palbociclib. |
Sodium Zirconium Cyclosilicate | Sodium Zirconium Cyclosilicate The absorption of Palbociclib can be decreased when combined with Sodium zirconium cyclosilicate. |
Eliglustat | Eliglustat The metabolism of Eliglustat can be decreased when combined with Palbociclib. |
Binimetinib | Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Palbociclib. |
Ivosidenib | Ivosidenib The metabolism of Ivosidenib can be increased when combined with Palbociclib. |
Lusutrombopag | Lusutrombopag Palbociclib may decrease the excretion rate of Lusutrombopag which could result in a higher serum level. |
Elagolix | Elagolix The serum concentration of Elagolix can be increased when it is combined with Palbociclib. |
Cannabidiol | Cannabidiol Cannabidiol may decrease the excretion rate of Palbociclib which could result in a higher serum level. |
Dacomitinib | Dacomitinib The serum concentration of Dacomitinib can be increased when it is combined with Palbociclib. |
Duvelisib | Duvelisib The metabolism of Duvelisib can be decreased when combined with Palbociclib. |
Omadacycline | Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Palbociclib. |
Stiripentol | Stiripentol The metabolism of Palbociclib can be decreased when combined with Stiripentol. |
Talazoparib | Talazoparib The serum concentration of Talazoparib can be increased when it is combined with Palbociclib. |
Gilteritinib | Gilteritinib The metabolism of Palbociclib can be decreased when combined with Gilteritinib. |
Glasdegib | Glasdegib Palbociclib may decrease the excretion rate of Glasdegib which could result in a higher serum level. |
Larotrectinib | Larotrectinib The serum concentration of Larotrectinib can be increased when it is combined with Palbociclib. |
Methoxy Polyethylene Glycol-Epoetin Beta Injection | Methoxy Polyethylene Glycol-Epoetin Beta Injection The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Palbociclib. |
Paclitaxel (with albumin) Injection | Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Palbociclib. |
Rifamycin | Rifamycin The metabolism of Rifamycin can be increased when combined with Palbociclib. |
Prucalopride | Prucalopride The serum concentration of Prucalopride can be increased when it is combined with Palbociclib. |
Ravulizumab-cwvz Injection | Ravulizumab-cwvz Injection The risk or severity of adverse effects can be increased when Palbociclib is combined with Ravulizumab. |
Emapalumab-lzsg Injection | Emapalumab-lzsg Injection The metabolism of Emapalumab can be increased when combined with Palbociclib. |
Siponimod | Siponimod The metabolism of Siponimod can be decreased when combined with Palbociclib. |
Acyclovir Ophthalmic | Acyclovir Ophthalmic The risk or severity of adverse effects can be increased when Palbociclib is combined with Acyclovir. |
Caplacizumab-yhdp Injection | Caplacizumab-yhdp Injection The risk or severity of bleeding can be increased when Caplacizumab is combined with Palbociclib. |
Erdafitinib | Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Palbociclib. |
Esomeprazole Injection | Esomeprazole Injection The absorption of Palbociclib can be decreased when combined with Esomeprazole. |
Risankizumab-rzaa Injection | Risankizumab-rzaa Injection The risk or severity of adverse effects can be increased when Palbociclib is combined with Risankizumab. |
Alpelisib | Alpelisib The serum concentration of Alpelisib can be increased when it is combined with Palbociclib. |
Cladribine | Cladribine The risk or severity of adverse effects can be increased when Cladribine is combined with Palbociclib. |
Darolutamide | Darolutamide The serum concentration of Darolutamide can be increased when it is combined with Palbociclib. |
Triclabendazole | Triclabendazole The metabolism of Palbociclib can be decreased when combined with Triclabendazole. |
Entrectinib | Entrectinib The metabolism of Entrectinib can be decreased when combined with Palbociclib. |
Pexidartinib | Pexidartinib The metabolism of Pexidartinib can be decreased when combined with Palbociclib. |
Istradefylline | Istradefylline Istradefylline may decrease the excretion rate of Palbociclib which could result in a higher serum level. |
Pitolisant | Pitolisant The serum concentration of Palbociclib can be decreased when it is combined with Pitolisant. |
Fedratinib | Fedratinib Fedratinib may decrease the excretion rate of Palbociclib which could result in a higher serum level. |
Lefamulin | Lefamulin Palbociclib may decrease the excretion rate of Lefamulin which could result in a higher serum level. |
Phenytoin Injection | Phenytoin Injection The metabolism of Palbociclib can be increased when combined with Phenytoin. |
Fosphenytoin Injection | Fosphenytoin Injection The metabolism of Fosphenytoin can be decreased when combined with Palbociclib. |
Enfortumab vedotin-ejfv Injection | Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be increased when it is combined with Palbociclib. |
Zanubrutinib | Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Palbociclib. |
Voxelotor | Voxelotor The serum concentration of Voxelotor can be increased when it is combined with Palbociclib. |
Lasmiditan | Lasmiditan The serum concentration of Palbociclib can be increased when it is combined with Lasmiditan. |
Ubrogepant | Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Palbociclib. |
Tazemetostat | Tazemetostat The metabolism of Tazemetostat can be decreased when combined with Palbociclib. |
Cenobamate | Cenobamate The serum concentration of Palbociclib can be decreased when it is combined with Cenobamate. |
Ozanimod | Ozanimod Palbociclib may decrease the excretion rate of Ozanimod which could result in a higher serum level. |
Selumetinib | Selumetinib Palbociclib may decrease the excretion rate of Selumetinib which could result in a higher serum level. |
Rimegepant | Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Palbociclib. |
Tucatinib | Tucatinib The metabolism of Tucatinib can be decreased when combined with Palbociclib. |
Remdesivir Injection | Remdesivir Injection The serum concentration of Remdesivir can be increased when it is combined with Palbociclib. |
Ripretinib | Ripretinib Palbociclib may decrease the excretion rate of Ripretinib which could result in a higher serum level. |
Capmatinib | Capmatinib The serum concentration of Palbociclib can be increased when it is combined with Capmatinib. |
Lemborexant | Lemborexant The serum concentration of Lemborexant can be increased when it is combined with Palbociclib. |
Fostemsavir | Fostemsavir Palbociclib may decrease the excretion rate of Fostemsavir which could result in a higher serum level. |
Octreotide | Octreotide The serum concentration of Palbociclib can be increased when it is combined with Octreotide. |
Belantamab Mafodotin-blmf Injection | Belantamab Mafodotin-blmf Injection The serum concentration of Belantamab mafodotin can be increased when it is combined with Palbociclib. |
Pralsetinib | Pralsetinib The serum concentration of Pralsetinib can be increased when it is combined with Palbociclib. |
Satralizumab-mwge Injection | Satralizumab-mwge Injection The serum concentration of Palbociclib can be decreased when it is combined with Satralizumab. |
Relugolix | Relugolix The serum concentration of Relugolix can be increased when it is combined with Palbociclib. |
Progestin-Only (drospirenone) Oral Contraceptives | Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Drospirenone can be decreased when combined with Palbociclib. |
Vitamin E (Alpha-Tocopherol) | Vitamin E (Alpha-Tocopherol) The metabolism of Palbociclib can be increased when combined with Vitamin E. |
Theophylline | Theophylline The metabolism of Theophylline can be decreased when combined with Palbociclib. |
Indomethacin | Indomethacin The risk or severity of adverse effects can be increased when Indomethacin is combined with Palbociclib. |
Sodium Bicarbonate | Sodium Bicarbonate The absorption of Palbociclib can be decreased when combined with Sodium bicarbonate. |
Hydroxyurea | Hydroxyurea The risk or severity of adverse effects can be increased when Hydroxyurea is combined with Palbociclib. |
Floxuridine | Floxuridine The risk or severity of adverse effects can be increased when Floxuridine is combined with Palbociclib. |
Phenobarbital | Phenobarbital The metabolism of Palbociclib can be increased when combined with Phenobarbital. |
Methotrexate Injection | Methotrexate Injection The metabolism of Palbociclib can be decreased when combined with Methotrexate. |
Primidone | Primidone The metabolism of Palbociclib can be increased when combined with Primidone. |
Chlorpromazine | Chlorpromazine The metabolism of Chlorpromazine can be increased when combined with Palbociclib. |
Diazepam | Diazepam The metabolism of Palbociclib can be decreased when combined with Diazepam. |
Lorazepam | Lorazepam The metabolism of Palbociclib can be decreased when combined with Lorazepam. |
Carmustine | Carmustine The risk or severity of adverse effects can be increased when Carmustine is combined with Palbociclib. |
Amantadine | Amantadine The risk or severity of adverse effects can be increased when Palbociclib is combined with Amantadine. |
Codeine | Codeine The risk or severity of adverse effects can be increased when Palbociclib is combined with Codeine. |
Bromocriptine | Bromocriptine The metabolism of Palbociclib can be decreased when combined with Bromocriptine. |
Tranylcypromine | Tranylcypromine The metabolism of Palbociclib can be decreased when combined with Tranylcypromine. |
Phenelzine | Phenelzine The metabolism of Palbociclib can be decreased when combined with Phenelzine. |
Procarbazine | Procarbazine The risk or severity of adverse effects can be increased when Procarbazine is combined with Palbociclib. |
Tetracycline | Tetracycline The metabolism of Palbociclib can be decreased when combined with Tetracycline. |
Thioguanine | Thioguanine The risk or severity of adverse effects can be increased when Tioguanine is combined with Palbociclib. |
Prochlorperazine | Prochlorperazine The metabolism of Palbociclib can be decreased when combined with Prochlorperazine. |
Bleomycin | Bleomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Palbociclib. |
Methadone | Methadone The metabolism of Palbociclib can be increased when combined with Methadone. |
Oxybutynin | Oxybutynin The metabolism of Palbociclib can be decreased when combined with Oxybutynin. |
Orphenadrine | Orphenadrine The metabolism of Palbociclib can be decreased when combined with Orphenadrine. |
Azathioprine | Azathioprine The risk or severity of adverse effects can be increased when Azathioprine is combined with Palbociclib. |
Phentermine | Phentermine The metabolism of Palbociclib can be decreased when combined with Phentermine. |
Sulfasalazine | Sulfasalazine The risk or severity of adverse effects can be increased when Sulfasalazine is combined with Palbociclib. |
Hydrocortisone | Hydrocortisone The metabolism of Palbociclib can be increased when combined with Hydrocortisone. |
Lomustine | Lomustine The risk or severity of adverse effects can be increased when Lomustine is combined with Palbociclib. |
Doxorubicin | Doxorubicin The serum concentration of Doxorubicin can be increased when it is combined with Palbociclib. |
Cytarabine | Cytarabine The risk or severity of adverse effects can be increased when Cytarabine is combined with Palbociclib. |
Mechlorethamine | Mechlorethamine The risk or severity of adverse effects can be increased when Mechlorethamine is combined with Palbociclib. |
Dactinomycin | Dactinomycin The serum concentration of Palbociclib can be increased when it is combined with Dactinomycin. |
Carbamazepine | Carbamazepine The metabolism of Carbamazepine can be decreased when combined with Palbociclib. |
Clonidine | Clonidine The metabolism of Clonidine can be decreased when combined with Palbociclib. |
Prazosin | Prazosin Palbociclib may decrease the excretion rate of Prazosin which could result in a higher serum level. |
Hydralazine | Hydralazine The metabolism of Palbociclib can be decreased when combined with Hydralazine. |
Cimetidine | Cimetidine The absorption of Palbociclib can be decreased when combined with Cimetidine. |
Warfarin | Warfarin The serum concentration of Warfarin can be increased when it is combined with Palbociclib. |
Loperamide | Loperamide The metabolism of Palbociclib can be decreased when combined with Loperamide. |
Daunorubicin | Daunorubicin The metabolism of Palbociclib can be decreased when combined with Daunorubicin. |
Nitrofurantoin | Nitrofurantoin Palbociclib may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level. |
Griseofulvin | Griseofulvin The metabolism of Palbociclib can be increased when combined with Griseofulvin. |
Digoxin | Digoxin Palbociclib may decrease the excretion rate of Digoxin which could result in a higher serum level. |
Quinine | Quinine The metabolism of Palbociclib can be increased when combined with Quinine. |
Calcitriol | Calcitriol The metabolism of Palbociclib can be increased when combined with Calcitriol. |
Sulfinpyrazone | Sulfinpyrazone The metabolism of Palbociclib can be increased when combined with Sulfinpyrazone. |
Chlorothiazide | Chlorothiazide The risk or severity of neutropenia and thrombocytopenia can be increased when Chlorothiazide is combined with Palbociclib. |
Secobarbital | Secobarbital The metabolism of Palbociclib can be increased when combined with Secobarbital. |
Desipramine | Desipramine The metabolism of Desipramine can be decreased when combined with Palbociclib. |
Imipramine | Imipramine The serum concentration of Imipramine can be increased when it is combined with Palbociclib. |
Probenecid | Probenecid The metabolism of Palbociclib can be increased when combined with Probenecid. |
Quinidine | Quinidine The serum concentration of Quinidine can be increased when it is combined with Palbociclib. |
Isoniazid | Isoniazid The metabolism of Palbociclib can be decreased when combined with Isoniazid. |
Rifampin | Rifampin The metabolism of Palbociclib can be increased when combined with Rifampicin. |
Valproic Acid | Valproic Acid The metabolism of Palbociclib can be decreased when combined with Valproic acid. |
Tamoxifen | Tamoxifen The metabolism of Tamoxifen can be increased when combined with Palbociclib. |
Mitomycin | Mitomycin The risk or severity of adverse effects can be increased when Mitomycin is combined with Palbociclib. |
Methimazole | Methimazole The metabolism of Palbociclib can be decreased when combined with Methimazole. |
Propylthiouracil | Propylthiouracil The risk or severity of adverse effects can be increased when Propylthiouracil is combined with Palbociclib. |
Niacin | Niacin The metabolism of Palbociclib can be decreased when combined with Niacin. |
Methyclothiazide | Methyclothiazide The risk or severity of neutropenia and thrombocytopenia can be increased when Methyclothiazide is combined with Palbociclib. |
Hydrochlorothiazide | Hydrochlorothiazide The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Palbociclib. |
Folic Acid | Folic Acid Palbociclib may decrease the excretion rate of Folic acid which could result in a higher serum level. |
Danazol | Danazol The metabolism of Palbociclib can be decreased when combined with Danazol. |
Nortriptyline | Nortriptyline The serum concentration of Nortriptyline can be increased when it is combined with Palbociclib. |
Amphotericin B Injection | Amphotericin B Injection The metabolism of Palbociclib can be decreased when combined with Amphotericin B. |
Mercaptopurine | Mercaptopurine The risk or severity of adverse effects can be increased when Mercaptopurine is combined with Palbociclib. |
Allopurinol | Allopurinol The risk or severity of adverse effects can be increased when Allopurinol is combined with Palbociclib. |
Clomiphene | Clomiphene The serum concentration of Clomifene can be increased when it is combined with Palbociclib. |
Fluorouracil Injection | Fluorouracil Injection The risk or severity of adverse effects can be increased when Fluorouracil is combined with Palbociclib. |
Colchicine | Colchicine The metabolism of Colchicine can be decreased when combined with Palbociclib. |
Cephalexin | Cephalexin The metabolism of Palbociclib can be decreased when combined with Cephalexin. |
Dacarbazine | Dacarbazine The risk or severity of adverse effects can be increased when Dacarbazine is combined with Palbociclib. |
Acetazolamide | Acetazolamide The metabolism of Palbociclib can be decreased when combined with Acetazolamide. |
Bacillus Calmette-Guerin (BCG) Vaccine | Bacillus Calmette-Guerin (BCG) Vaccine The risk or severity of infection can be increased when Bacillus calmette-guerin substrain tice live antigen is combined with Palbociclib. |
Ketoconazole | Ketoconazole The metabolism of Palbociclib can be decreased when combined with Ketoconazole. |
Thiotepa Injection | Thiotepa Injection The metabolism of Palbociclib can be decreased when combined with Thiotepa. |
Vincristine Injection | Vincristine Injection The excretion of Vincristine can be decreased when combined with Palbociclib. |
Dipyridamole | Dipyridamole The risk or severity of bleeding can be increased when Dipyridamole is combined with Palbociclib. |
Vinblastine | Vinblastine The metabolism of Palbociclib can be decreased when combined with Vinblastine. |
Metoprolol | Metoprolol The metabolism of Metoprolol can be decreased when combined with Palbociclib. |
Aspirin | Aspirin The risk or severity of bleeding can be increased when Acetylsalicylic acid is combined with Palbociclib. |
Chlorambucil | Chlorambucil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Palbociclib. |
Alprazolam | Alprazolam The metabolism of Alprazolam can be decreased when combined with Palbociclib. |
Diltiazem | Diltiazem The metabolism of Palbociclib can be decreased when combined with Diltiazem. |
Nifedipine | Nifedipine The metabolism of Palbociclib can be increased when combined with Nifedipine. |
Verapamil | Verapamil The metabolism of Verapamil can be decreased when combined with Palbociclib. |
Cisplatin Injection | Cisplatin Injection The risk or severity of adverse effects can be increased when Cisplatin is combined with Palbociclib. |
Streptozocin | Streptozocin The risk or severity of adverse effects can be increased when Streptozocin is combined with Palbociclib. |
Etoposide | Etoposide The serum concentration of Palbociclib can be increased when it is combined with Etoposide. |
Glyburide | Glyburide The metabolism of Glyburide can be decreased when combined with Palbociclib. |
Dicloxacillin | Dicloxacillin The metabolism of Palbociclib can be increased when combined with Dicloxacillin. |
Nafcillin Injection | Nafcillin Injection The metabolism of Palbociclib can be increased when combined with Nafcillin. |
Pentoxifylline | Pentoxifylline The risk or severity of bleeding can be increased when Pentoxifylline is combined with Palbociclib. |
Pimozide | Pimozide The metabolism of Pimozide can be decreased when combined with Palbociclib. |
Amiodarone | Amiodarone The metabolism of Amiodarone can be decreased when combined with Palbociclib. |
Lovastatin | Lovastatin The metabolism of Lovastatin can be decreased when combined with Palbociclib. |
Ciprofloxacin | Ciprofloxacin The metabolism of Palbociclib can be decreased when combined with Ciprofloxacin. |
Interferon Alfa-2b Injection | Interferon Alfa-2b Injection The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Palbociclib. |
Clozapine | Clozapine The risk or severity of neutropenia can be increased when Palbociclib is combined with Clozapine. |
Idarubicin | Idarubicin The risk or severity of adverse effects can be increased when Idarubicin is combined with Palbociclib. |
Fludarabine Injection | Fludarabine Injection The risk or severity of adverse effects can be increased when Fludarabine is combined with Palbociclib. |
Pentostatin Injection | Pentostatin Injection The risk or severity of adverse effects can be increased when Pentostatin is combined with Palbociclib. |
Clarithromycin | Clarithromycin The metabolism of Palbociclib can be decreased when combined with Clarithromycin. |
Felodipine | Felodipine The metabolism of Palbociclib can be decreased when combined with Felodipine. |
Pravastatin | Pravastatin Pravastatin may decrease the excretion rate of Palbociclib which could result in a higher serum level. |
Simvastatin | Simvastatin The serum concentration of Palbociclib can be increased when it is combined with Simvastatin. |
Epoetin Alfa, Injection | Epoetin Alfa, Injection The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Palbociclib. |
Teniposide Injection | Teniposide Injection The metabolism of Palbociclib can be decreased when combined with Teniposide. |
Itraconazole | Itraconazole The metabolism of Palbociclib can be decreased when combined with Itraconazole. |
Rifabutin | Rifabutin The metabolism of Palbociclib can be increased when combined with Rifabutin. |
Bisoprolol | Bisoprolol The serum concentration of Bisoprolol can be increased when it is combined with Palbociclib. |
Doxazosin | Doxazosin The metabolism of Doxazosin can be decreased when combined with Palbociclib. |
Isradipine | Isradipine The metabolism of Palbociclib can be decreased when combined with Isradipine. |
Omeprazole | Omeprazole The absorption of Palbociclib can be decreased when combined with Omeprazole. |
Cisapride | Cisapride The metabolism of Palbociclib can be decreased when combined with Cisapride. |
Fluvastatin | Fluvastatin The metabolism of Palbociclib can be decreased when combined with Fluvastatin. |
Venlafaxine | Venlafaxine Venlafaxine may increase the excretion rate of Palbociclib which could result in a lower serum level and potentially a reduction in efficacy. |
Nizatidine | Nizatidine The absorption of Palbociclib can be decreased when combined with Nizatidine. |
Famciclovir | Famciclovir The metabolism of Palbociclib can be decreased when combined with Famciclovir. |
Fluvoxamine | Fluvoxamine The metabolism of Palbociclib can be decreased when combined with Fluvoxamine. |
Nefazodone | Nefazodone The metabolism of Palbociclib can be decreased when combined with Nefazodone. |
Losartan | Losartan The metabolism of Palbociclib can be decreased when combined with Losartan. |
Tramadol | Tramadol The metabolism of Tramadol can be decreased when combined with Palbociclib. |
Vinorelbine Injection | Vinorelbine Injection The metabolism of Palbociclib can be decreased when combined with Vinorelbine. |
Carboplatin Injection | Carboplatin Injection The risk or severity of adverse effects can be increased when Carboplatin is combined with Palbociclib. |
Lansoprazole | Lansoprazole The absorption of Palbociclib can be decreased when combined with Lansoprazole. |
Ifosfamide Injection | Ifosfamide Injection The metabolism of Palbociclib can be increased when combined with Ifosfamide. |
Pegaspargase Injection | Pegaspargase Injection The risk or severity of adverse effects can be increased when Pegaspargase is combined with Palbociclib. |
Nicardipine | Nicardipine The metabolism of Palbociclib can be decreased when combined with Nicardipine. |
Ticlopidine | Ticlopidine The metabolism of Palbociclib can be decreased when combined with Ticlopidine. |
Saquinavir | Saquinavir The metabolism of Saquinavir can be decreased when combined with Palbociclib. |
Metformin | Metformin The risk or severity of adverse effects can be increased when Palbociclib is combined with Metformin. |
Dalteparin Injection | Dalteparin Injection The risk or severity of bleeding can be increased when Dalteparin is combined with Palbociclib. |
Lamivudine | Lamivudine Palbociclib may decrease the excretion rate of Lamivudine which could result in a higher serum level. |
Riluzole | Riluzole Palbociclib may decrease the excretion rate of Riluzole which could result in a higher serum level. |
Gemcitabine Injection | Gemcitabine Injection The serum concentration of Palbociclib can be increased when it is combined with Gemcitabine. |
Ritonavir | Ritonavir The metabolism of Palbociclib can be decreased when combined with Ritonavir. |
Docetaxel Injection | Docetaxel Injection The metabolism of Palbociclib can be decreased when combined with Docetaxel. |
Clomipramine | Clomipramine The metabolism of Clomipramine can be decreased when combined with Palbociclib. |
Zafirlukast | Zafirlukast The metabolism of Palbociclib can be decreased when combined with Zafirlukast. |
Mirtazapine | Mirtazapine The metabolism of Palbociclib can be decreased when combined with Mirtazapine. |
Topiramate | Topiramate The metabolism of Palbociclib can be increased when combined with Topiramate. |
Pramipexole | Pramipexole The risk or severity of adverse effects can be increased when Palbociclib is combined with Pramipexole. |
Donepezil | Donepezil Palbociclib may decrease the excretion rate of Donepezil which could result in a higher serum level. |
Nelfinavir | Nelfinavir Nelfinavir may decrease the excretion rate of Palbociclib which could result in a higher serum level. |
Fexofenadine | Fexofenadine The serum concentration of Palbociclib can be increased when it is combined with Fexofenadine. |
Azithromycin | Azithromycin The metabolism of Azithromycin can be decreased when combined with Palbociclib. |
Bicalutamide | Bicalutamide The metabolism of Palbociclib can be decreased when combined with Bicalutamide. |
Raloxifene | Raloxifene The metabolism of Raloxifene can be decreased when combined with Palbociclib. |
Irbesartan | Irbesartan The metabolism of Palbociclib can be decreased when combined with Irbesartan. |
Paroxetine | Paroxetine The metabolism of Palbociclib can be decreased when combined with Paroxetine. |
Citalopram | Citalopram The metabolism of Palbociclib can be decreased when combined with Citalopram. |
Capecitabine | Capecitabine The risk or severity of adverse effects can be increased when Capecitabine is combined with Palbociclib. |
Efavirenz | Efavirenz The metabolism of Palbociclib can be decreased when combined with Efavirenz. |
Sildenafil | Sildenafil The serum concentration of Palbociclib can be increased when it is combined with Sildenafil. |
Trastuzumab Injection | Trastuzumab Injection Trastuzumab may increase the neutropenic activities of Palbociclib. |
Celecoxib | Celecoxib Palbociclib may decrease the excretion rate of Celecoxib which could result in a higher serum level. |
Thalidomide | Thalidomide The risk or severity of adverse effects can be increased when Thalidomide is combined with Palbociclib. |
Aluminum Hydroxide | Aluminum Hydroxide The absorption of Palbociclib can be decreased when combined with Aluminum hydroxide. |
Rabeprazole | Rabeprazole The absorption of Palbociclib can be decreased when combined with Rabeprazole. |
Terbinafine | Terbinafine The metabolism of Palbociclib can be increased when combined with Terbinafine. |
Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists