Palbociclib

Generic name: Pronounced as (pal'' boe sye' klib)
Brand names
  • Ibrance®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 06/15/2019

[Posted 09/13/2019]

AUDIENCE: Patient, Health Professional, Oncology

ISSUE: FDA is warning that palbociclib (Ibrance®), ribociclib (Kisqali®), and abemaciclib (Verzenio®) used to treat some patients with advanced breast cancers may cause rare but severe inflammation of the lungs. FDA has approved new warnings about this risk to the prescribing information and Patient Package Insert for the entire class of these cyclin-dependent kinase 4/6 (CDK 4/6) inhibitor medicines. The overall benefit of CDK 4/6 inhibitors is still greater than the risks when used as prescribed.

BACKGROUND: CDK 4/6 inhibitors are a class of prescription medicines that are used in combination with hormone therapies to treat adults with hormone receptor (HR)-positive, human epidermal growth factor 2 (HER2)-negative advanced or metastatic breast cancer that has spread to other parts of the body. CDK 4/6 inhibitors block certain molecules involved in promoting the growth of cancer cells. FDA approved palbociclib in 2015, and both ribociclib and abemaciclib in 2017. CDK 4/6 inhibitors have been shown to improve the amount of time after the start of treatment the cancer does not grow substantially and the patient is alive, called progression-free survival (See List of FDA-Approved CDK 4/6 Inhibitors below).

RECOMMENDATION: Patients should notify your health care professional right away if you have any new or worsening symptoms involving your lungs, as they may indicate a rare but life-threatening condition that can lead to death. Symptoms to watch for include:

  • Difficulty or discomfort with breathing

  • Shortness of breath while at rest or with low activity

Do not stop taking your medicine without first talking to your health care professional. All medicines have side effects even when used correctly as prescribed, but in general the benefits of taking these medicines outweigh these risks. It is important to know that people respond differently to all medicines depending on their health, the diseases they have, genetic factors, other medicines they are taking, and many other factors. Specific risk factors to determine how likely it is that a particular person will experience severe lung inflammation when taking palbociclib, ribociclib, or abemaciclib have not been identified.

Health care professionals should monitor patients regularly for pulmonary symptoms indicative of interstitial lung disease (ILD) and/or pneumonitis. Signs and symptoms may include:

  • hypoxia

  • cough

  • dyspnea

  • interstitial infiltrates on radiologic exams in patients in whom infectious, neoplastic, and other causes have been excluded.

Interrupt CDK 4/6 inhibitor treatment in patients who have new or worsening respiratory symptoms, and permanently discontinue treatment in patients with severe ILD and/or pneumonitis.

For more information visit the FDA website at: http://www.fda.gov/Safety/MedWatch/SafetyInformation and http://www.fda.gov/Drugs/DrugSafety.

Palbociclib is used in combination with anastrozole (Arimidex), exemestane (Aromasin), or letrozole (Femara) to treat a certain type of hormone receptor–positive, advanced breast cancer (breast cancer that depends on hormones such as estrogen to grow) or breast cancer that has spread to other parts of the body in women who have experienced menopause (change of life; end of monthly menstrual periods) or in men. Palbociclib is also used along with fulvestrant (Faslodex) to treat a certain type of hormone receptor–positive, advanced breast cancer (breast cancer that depends on hormones such as estrogen to grow) or breast cancer that has spread to other parts of the body in people who have been treated with an antiestrogen medication such as tamoxifen (Nolvadex). Palbociclib is in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps stop or slow the spread of cancer cells.

Palbociclib comes as a capsule to take by mouth. It is usually taken with food once daily for the first 21 days of a 28-day cycle. Your doctor will decide how many times you should repeat this cycle. Take palbociclib at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take palbociclib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the capsules whole; do not open, chew, or crush them. Do not take capsules that are broken or cracked.

If you vomit after taking palbociclib, do not take another dose. Continue your regular dosing schedule.

Your doctor may decrease your dose or temporarily or permanently stop your treatment if you experience certain side effects. Be sure to tell your doctor how you are feeling during your treatment with palbociclib.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking palbociclib,

  • tell your doctor and pharmacist if you are allergic to palbociclib, any other medications, or any of the ingredients in palbociclib capsules. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antifungals such as itraconazole (Onmel, Sporanox, Tolsura), ketoconazole, posaconazole (Noxafil), and voriconazole (Vfend); certain medications to treat seizures such as carbamazepine (Carbatrol, Equetro, Epitol, Tegretol, others) and phenytoin (Dilantin, Phenytek); clarithromycin; enzalutamide (Xtandi); ergot alkaloids such as dihydroergotamine (D.H.E 45, Migranal) and ergotamine (Ergomar, in Cafergot, in Migergot); certain medications for human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) including indinavir (Crixivan), lopinavir (in Kaletra), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra, in Viekira Pak), saquinavir (Invirase), and telaprevir (no longer available in the U.S.); fentanyl (Abstral, Fentora, Lazanda, Subsys, others); immunosuppressants such as cyclosporine (Gengraf, Neoral, Sandimmune), everolimus (Afinitor, Zortress), sirolimus (Rapamune), and tacrolimus (Astagraf XL, Envarsus XR, Prograf); midazolam; nefazodone; pimozide (Orap); quinidine (in Nuedexta); rifampin (Rimactane, Rifadin, in Rifater, in Rifamate); and telithromycin (Ketek). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with palbociclib, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

  • tell your doctor and pharmacist what herbal products you are taking, especially St. John's wort.

  • tell your doctor if you have an infection or if you have or have ever had liver or kidney disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or if you plan on fathering a child. If you are female, you will need to take a pregnancy test before you start treatment and use birth control to prevent pregnancy during your treatment and for at least 3 weeks after your final dose. If you are a male, you and your partner should use birth control during your treatment with palbociclib and for 3 months after your final dose. Talk to your doctor about birth control methods that you can use during your treatment. If you or your partner become pregnant while taking palbociclib, call your doctor immediately. Palbociclib may harm the fetus.

  • tell your doctor if you are breastfeeding. You should not breastfeed while you are taking palbociclib and for 3 weeks after the final dose.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking palbociclib.

  • you should know that this medication may decrease fertility in men. Talk to your doctor about the risks of taking palbociclib.

Do not eat grapefruit or drink grapefruit juice while taking this medication.

Skip the missed dose and continue your regular dosing schedule. Do not take a double dose on the same day to make up for a missed one.

  • Palbociclib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • nausea

    • diarrhea

    • vomiting

    • decreased appetite

    • changes in taste

    • tiredness

    • numbness or tingling in your arms, hands, legs, and feet

    • sores on the lips, mouth, or throat

    • unusual hair thinning or hair loss

    • dry skin

    • rash

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

    • fever, chills, or signs of infection

    • shortness of breath

    • dizziness

    • fast, irregular, or pounding heartbeat

    • weakness

    • unusual bleeding or bruising

    • nosebleeds

  • Palbociclib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests before and during your treatment to check your body's response to palbociclib.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Leflunomide Leflunomide The risk or severity of adverse effects can be increased when Palbociclib is combined with Leflunomide.
Delavirdine Delavirdine The metabolism of Palbociclib can be decreased when combined with Delavirdine.
Atorvastatin Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Palbociclib.
Aminophylline Aminophylline The metabolism of Aminophylline can be decreased when combined with Palbociclib.
Anagrelide Anagrelide The risk or severity of bleeding can be increased when Anagrelide is combined with Palbociclib.
Calcium Carbonate Calcium Carbonate The absorption of Palbociclib can be decreased when combined with Calcium carbonate.
Cilostazol Cilostazol The metabolism of Cilostazol can be decreased when combined with Palbociclib.
Clopidogrel Clopidogrel The risk or severity of bleeding can be increased when Clopidogrel is combined with Palbociclib.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The metabolism of Palbociclib can be decreased when combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Palbociclib may decrease the excretion rate of Conjugated estrogens which could result in a higher serum level.
Fenofibrate Fenofibrate The metabolism of Fenofibrate can be decreased when combined with Palbociclib.
Guanfacine Guanfacine The risk or severity of adverse effects can be increased when Palbociclib is combined with Guanfacine.
Magnesium Hydroxide Magnesium Hydroxide The absorption of Palbociclib can be decreased when combined with Magnesium hydroxide.
Magnesium Oxide Magnesium Oxide The absorption of Palbociclib can be decreased when combined with Magnesium oxide.
Methylergonovine Methylergonovine The metabolism of Palbociclib can be decreased when combined with Methylergometrine.
Mycophenolate Mycophenolate The risk or severity of adverse effects can be increased when Mycophenolic acid is combined with Palbociclib.
Paregoric Paregoric The serum concentration of Morphine can be increased when it is combined with Palbociclib.
Prednisone Prednisone The risk or severity of adverse effects can be increased when Prednisone is combined with Palbociclib.
Ranitidine Ranitidine The absorption of Palbociclib can be decreased when combined with Ranitidine.
Sumatriptan Sumatriptan Palbociclib may decrease the excretion rate of Sumatriptan which could result in a higher serum level.
Tacrolimus Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Palbociclib.
Triamcinolone Triamcinolone The metabolism of Palbociclib can be increased when combined with Triamcinolone.
Doxycycline Injection Doxycycline Injection The metabolism of Palbociclib can be decreased when combined with Doxycycline.
Famotidine Injection Famotidine Injection The absorption of Palbociclib can be decreased when combined with Famotidine.
Fluconazole Injection Fluconazole Injection The metabolism of Palbociclib can be decreased when combined with Fluconazole.
Interferon Beta-1b Injection Interferon Beta-1b Injection The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Palbociclib.
Interferon Gamma-1b Injection Interferon Gamma-1b Injection The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Palbociclib.
Meperidine Injection Meperidine Injection The metabolism of Meperidine can be increased when combined with Palbociclib.
Methylprednisolone Injection Methylprednisolone Injection The metabolism of Palbociclib can be increased when combined with Methylprednisolone.
Metronidazole Injection Metronidazole Injection The metabolism of Palbociclib can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection The serum concentration of Morphine can be increased when it is combined with Palbociclib.
Zidovudine Injection Zidovudine Injection The risk or severity of adverse effects can be increased when Zidovudine is combined with Palbociclib.
Cyclosporine Cyclosporine Palbociclib may increase the immunosuppressive activities of Cyclosporine.
Enoxaparin Injection Enoxaparin Injection The risk or severity of bleeding can be increased when Enoxaparin is combined with Palbociclib.
Dofetilide Dofetilide The metabolism of Dofetilide can be decreased when combined with Palbociclib.
Hydroxychloroquine Hydroxychloroquine The risk or severity of adverse effects can be increased when Hydroxychloroquine is combined with Palbociclib.
Orlistat Orlistat The metabolism of Palbociclib can be increased when combined with Orlistat.
Oxcarbazepine Oxcarbazepine The metabolism of Palbociclib can be increased when combined with Oxcarbazepine.
Pantoprazole Pantoprazole The absorption of Palbociclib can be decreased when combined with Pantoprazole.
Telmisartan Telmisartan Telmisartan may decrease the excretion rate of Palbociclib which could result in a higher serum level.
Temozolomide Temozolomide The risk or severity of adverse effects can be increased when Temozolomide is combined with Palbociclib.
Anakinra Anakinra The metabolism of Palbociclib can be increased when combined with Anakinra.
Linezolid Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Palbociclib.
Pentosan Polysulfate Pentosan Polysulfate The risk or severity of bleeding can be increased when Pentosan polysulfate is combined with Palbociclib.
Trimipramine Trimipramine The serum concentration of Trimipramine can be increased when it is combined with Palbociclib.
Etanercept Injection Etanercept Injection The metabolism of Palbociclib can be increased when combined with Etanercept.
Modafinil Modafinil The metabolism of Palbociclib can be increased when combined with Modafinil.
Tenofovir Tenofovir The metabolism of Tenofovir can be decreased when combined with Palbociclib.
Sirolimus Sirolimus The serum concentration of Sirolimus can be increased when it is combined with Palbociclib.
Epinephrine Injection Epinephrine Injection The metabolism of Epinephrine can be decreased when combined with Palbociclib.
Epirubicin Epirubicin The risk or severity of adverse effects can be increased when Epirubicin is combined with Palbociclib.
Adalimumab Injection Adalimumab Injection The metabolism of Palbociclib can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Palbociclib.
Ezetimibe Ezetimibe Palbociclib may decrease the excretion rate of Ezetimibe which could result in a higher serum level.
Glatiramer Injection Glatiramer Injection The risk or severity of adverse effects can be increased when Glatiramer is combined with Palbociclib.
Atazanavir Atazanavir The metabolism of Palbociclib can be decreased when combined with Atazanavir.
Mefloquine Mefloquine The metabolism of Palbociclib can be decreased when combined with Mefloquine.
Rosuvastatin Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Palbociclib.
Vardenafil Vardenafil The metabolism of Vardenafil can be decreased when combined with Palbociclib.
Alfuzosin Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Palbociclib.
Aprepitant Aprepitant The metabolism of Palbociclib can be decreased when combined with Aprepitant.
Tegaserod Tegaserod Palbociclib may decrease the excretion rate of Tegaserod which could result in a higher serum level.
Progesterone Progesterone The metabolism of Palbociclib can be increased when combined with Progesterone.
Darbepoetin Alfa Injection Darbepoetin Alfa Injection The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Palbociclib.
Infliximab Injection Infliximab Injection The metabolism of Palbociclib can be increased when combined with Infliximab.
Rifaximin Rifaximin The serum concentration of Rifaximin can be increased when it is combined with Palbociclib.
Duloxetine Duloxetine The metabolism of Duloxetine can be decreased when combined with Palbociclib.
Norethindrone Norethindrone The metabolism of Palbociclib can be decreased when combined with Norethisterone.
Bosentan Bosentan The metabolism of Palbociclib can be increased when combined with Bosentan.
Natalizumab Injection Natalizumab Injection The risk or severity of adverse effects can be increased when Palbociclib is combined with Natalizumab.
Erlotinib Erlotinib The metabolism of Palbociclib can be decreased when combined with Erlotinib.
Eszopiclone Eszopiclone The metabolism of Eszopiclone can be decreased when combined with Palbociclib.
Ganciclovir Ganciclovir The risk or severity of adverse effects can be increased when Palbociclib is combined with Ganciclovir.
Palifermin Palifermin The therapeutic efficacy of Palifermin can be decreased when used in combination with Palbociclib.
Voriconazole Voriconazole The metabolism of Palbociclib can be decreased when combined with Voriconazole.
Peginterferon Alfa-2a Injection Peginterferon Alfa-2a Injection The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Palbociclib.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Palbociclib.
Fentanyl Fentanyl The metabolism of Fentanyl can be decreased when combined with Palbociclib.
Deferasirox Deferasirox The metabolism of Palbociclib can be increased when combined with Deferasirox.
Tipranavir Tipranavir The metabolism of Tipranavir can be decreased when combined with Palbociclib.
Felbamate Felbamate The metabolism of Palbociclib can be increased when combined with Felbamate.
Ranolazine Ranolazine The serum concentration of Ranolazine can be increased when it is combined with Palbociclib.
Abatacept Injection Abatacept Injection The metabolism of Palbociclib can be increased when combined with Abatacept.
Imatinib Imatinib The metabolism of Palbociclib can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin The serum concentration of Sitagliptin can be increased when it is combined with Palbociclib.
Bevacizumab Injection Bevacizumab Injection The risk or severity of adverse effects can be increased when Bevacizumab is combined with Palbociclib.
Gefitinib Gefitinib The metabolism of Palbociclib can be decreased when combined with Gefitinib.
Paliperidone Paliperidone The serum concentration of Palbociclib can be increased when it is combined with Paliperidone.
Bortezomib Bortezomib The metabolism of Palbociclib can be decreased when combined with Bortezomib.
Clofarabine Injection Clofarabine Injection The risk or severity of adverse effects can be increased when Clofarabine is combined with Palbociclib.
Hepatitis B Vaccine Hepatitis B Vaccine The therapeutic efficacy of Hepatitis B Vaccine (Recombinant) can be decreased when used in combination with Palbociclib.
Influenza Vaccine, Inactivated or Recombinant Influenza Vaccine, Inactivated or Recombinant The therapeutic efficacy of Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Palbociclib.
Influenza Vaccine, Live Intranasal Influenza Vaccine, Live Intranasal The risk or severity of infection can be increased when Typhoid Vaccine Live is combined with Palbociclib.
Live Shingles (Zoster) Vaccine (ZVL) Live Shingles (Zoster) Vaccine (ZVL) The risk or severity of infection can be increased when Varicella Zoster Vaccine (Live/attenuated) is combined with Palbociclib.
Oxaliplatin Injection Oxaliplatin Injection The risk or severity of adverse effects can be increased when Oxaliplatin is combined with Palbociclib.
Posaconazole Posaconazole The metabolism of Palbociclib can be decreased when combined with Posaconazole.
Primaquine Primaquine The metabolism of Palbociclib can be decreased when combined with Primaquine.
Rituximab Injection Rituximab Injection The risk or severity of adverse effects can be increased when Rituximab is combined with Palbociclib.
Darunavir Darunavir The serum concentration of Darunavir can be increased when it is combined with Palbociclib.
Pemetrexed Injection Pemetrexed Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Palbociclib.
Retapamulin Retapamulin The metabolism of Retapamulin can be decreased when combined with Palbociclib.
Vorinostat Vorinostat The risk or severity of adverse effects can be increased when Vorinostat is combined with Palbociclib.
Sorafenib Sorafenib The metabolism of Palbociclib can be decreased when combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Palbociclib can be decreased when combined with Sunitinib.
Dronabinol Dronabinol Dronabinol may decrease the excretion rate of Palbociclib which could result in a higher serum level.
Lapatinib Lapatinib The metabolism of Palbociclib can be decreased when combined with Lapatinib.
Dasatinib Dasatinib The metabolism of Dasatinib can be decreased when combined with Palbociclib.
Armodafinil Armodafinil The metabolism of Palbociclib can be increased when combined with Armodafinil.
Azacitidine Injection Azacitidine Injection The risk or severity of adverse effects can be increased when Azacitidine is combined with Palbociclib.
Ivermectin Ivermectin The metabolism of Ivermectin can be increased when combined with Palbociclib.
Temsirolimus Temsirolimus The serum concentration of Temsirolimus can be increased when it is combined with Palbociclib.
Nelarabine Injection Nelarabine Injection The risk or severity of adverse effects can be increased when Nelarabine is combined with Palbociclib.
Lenalidomide Lenalidomide The risk or severity of adverse effects can be increased when Lenalidomide is combined with Palbociclib.
Nilotinib Nilotinib The metabolism of Palbociclib can be decreased when combined with Nilotinib.
Toremifene Toremifene The serum concentration of Palbociclib can be increased when it is combined with Toremifene.
Bexarotene Bexarotene The metabolism of Palbociclib can be increased when combined with Bexarotene.
Budesonide Budesonide The metabolism of Palbociclib can be increased when combined with Budesonide.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Palbociclib can be decreased when combined with Chloramphenicol.
Decitabine Injection Decitabine Injection The risk or severity of adverse effects can be increased when Decitabine is combined with Palbociclib.
Etravirine Etravirine The metabolism of Palbociclib can be increased when combined with Etravirine.
Arsenic Trioxide Injection Arsenic Trioxide Injection The risk or severity of adverse effects can be increased when Arsenic trioxide is combined with Palbociclib.
Mitoxantrone Injection Mitoxantrone Injection The metabolism of Palbociclib can be decreased when combined with Mitoxantrone.
Desvenlafaxine Desvenlafaxine The metabolism of Palbociclib can be decreased when combined with Desvenlafaxine.
Tretinoin Tretinoin The risk or severity of adverse effects can be increased when Tretinoin is combined with Palbociclib.
Bendamustine Injection Bendamustine Injection The serum concentration of Palbociclib can be increased when it is combined with Bendamustine.
Pilocarpine Pilocarpine The metabolism of Palbociclib can be decreased when combined with Pilocarpine.
Certolizumab Injection Certolizumab Injection The metabolism of Palbociclib can be increased when combined with Certolizumab pegol.
Ixabepilone Injection Ixabepilone Injection The metabolism of Palbociclib can be decreased when combined with Ixabepilone.
Irinotecan Injection Irinotecan Injection The metabolism of Palbociclib can be decreased when combined with Irinotecan.
Estramustine Estramustine The risk or severity of adverse effects can be increased when Estramustine is combined with Palbociclib.
Mitotane Mitotane The metabolism of Palbociclib can be increased when combined with Mitotane.
Alemtuzumab Injection (Chronic Lymphocytic Leukemia) Alemtuzumab Injection (Chronic Lymphocytic Leukemia) The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Palbociclib.
Rufinamide Rufinamide The metabolism of Rufinamide can be increased when combined with Palbociclib.
Silodosin Silodosin The serum concentration of Silodosin can be increased when it is combined with Palbociclib.
Midazolam Midazolam The serum concentration of Midazolam can be increased when it is combined with Palbociclib.
Dexrazoxane Injection Dexrazoxane Injection The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Palbociclib.
Eltrombopag Eltrombopag Eltrombopag may decrease the excretion rate of Palbociclib which could result in a higher serum level.
Ibritumomab Injection Ibritumomab Injection The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Palbociclib.
Milnacipran Milnacipran The metabolism of Palbociclib can be decreased when combined with Milnacipran.
Dexlansoprazole Dexlansoprazole The absorption of Palbociclib can be decreased when combined with Dexlansoprazole.
Iloperidone Iloperidone The metabolism of Iloperidone can be decreased when combined with Palbociclib.
Prasugrel Prasugrel The risk or severity of bleeding can be increased when Prasugrel is combined with Palbociclib.
Lacosamide Lacosamide The metabolism of Palbociclib can be decreased when combined with Lacosamide.
Everolimus Everolimus The serum concentration of Everolimus can be increased when it is combined with Palbociclib.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The serum concentration of Tolvaptan can be increased when it is combined with Palbociclib.
Dronedarone Dronedarone The serum concentration of Dronedarone can be increased when it is combined with Palbociclib.
Pralatrexate Injection Pralatrexate Injection The risk or severity of adverse effects can be increased when Pralatrexate is combined with Palbociclib.
Romidepsin Injection Romidepsin Injection The serum concentration of Romidepsin can be increased when it is combined with Palbociclib.
Topotecan Topotecan The serum concentration of Topotecan can be increased when it is combined with Palbociclib.
Golimumab Injection Golimumab Injection The metabolism of Palbociclib can be increased when combined with Golimumab.
Pazopanib Pazopanib The serum concentration of Pazopanib can be increased when it is combined with Palbociclib.
Pitavastatin Pitavastatin Palbociclib may decrease the excretion rate of Pitavastatin which could result in a higher serum level.
Albendazole Albendazole The metabolism of Albendazole can be decreased when combined with Palbociclib.
Denosumab Injection Denosumab Injection The risk or severity of adverse effects can be increased when Denosumab is combined with Palbociclib.
Dabigatran Dabigatran The risk or severity of bleeding can be increased when Dabigatran is combined with Palbociclib.
Tocilizumab Injection Tocilizumab Injection The metabolism of Palbociclib can be increased when combined with Tocilizumab.
Fingolimod Fingolimod Palbociclib may increase the immunosuppressive activities of Fingolimod.
Eribulin Injection Eribulin Injection The risk or severity of adverse effects can be increased when Eribulin is combined with Palbociclib.
Cabazitaxel Injection Cabazitaxel Injection The serum concentration of Palbociclib can be increased when it is combined with Cabazitaxel.
Acetaminophen Injection Acetaminophen Injection The metabolism of Palbociclib can be increased when combined with Acetaminophen.
Denileukin Diftitox Injection Denileukin Diftitox Injection The metabolism of Palbociclib can be decreased when combined with Aldesleukin.
Sipuleucel-T Injection Sipuleucel-T Injection The therapeutic efficacy of Sipuleucel-T can be decreased when used in combination with Palbociclib.
Belimumab Injection Belimumab Injection The risk or severity of adverse effects can be increased when Belimumab is combined with Palbociclib.
Busulfan Injection Busulfan Injection The metabolism of Palbociclib can be decreased when combined with Busulfan.
Roflumilast Roflumilast Roflumilast may increase the immunosuppressive activities of Palbociclib.
Linagliptin Linagliptin The metabolism of Palbociclib can be decreased when combined with Linagliptin.
Rilpivirine Rilpivirine The metabolism of Palbociclib can be decreased when combined with Rilpivirine.
Telaprevir Telaprevir The metabolism of Glecaprevir can be decreased when combined with Palbociclib.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Palbociclib can be increased when combined with Cyclophosphamide.
Rivaroxaban Rivaroxaban Palbociclib may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Ticagrelor Ticagrelor The metabolism of Ticagrelor can be decreased when combined with Palbociclib.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The serum concentration of Brentuximab vedotin can be increased when it is combined with Palbociclib.
Ruxolitinib Ruxolitinib The metabolism of Palbociclib can be decreased when combined with Ruxolitinib.
Vandetanib Vandetanib The metabolism of Palbociclib can be decreased when combined with Vandetanib.
Clobazam Clobazam The metabolism of Clobazam can be increased when combined with Palbociclib.
Vemurafenib Vemurafenib The metabolism of Palbociclib can be decreased when combined with Vemurafenib.
Vismodegib Vismodegib Vismodegib may decrease the excretion rate of Palbociclib which could result in a higher serum level.
Belatacept Injection Belatacept Injection The risk or severity of adverse effects can be increased when Belatacept is combined with Palbociclib.
Ivacaftor Ivacaftor The metabolism of Palbociclib can be decreased when combined with Ivacaftor.
Basiliximab Injection Basiliximab Injection The risk or severity of adverse effects can be increased when Basiliximab is combined with Palbociclib.
Axitinib Axitinib The metabolism of Axitinib can be decreased when combined with Palbociclib.
Crizotinib Crizotinib The metabolism of Palbociclib can be decreased when combined with Crizotinib.
Melphalan Injection Melphalan Injection The risk or severity of adverse effects can be increased when Melphalan is combined with Palbociclib.
Cabergoline Cabergoline The metabolism of Cabergoline can be decreased when combined with Palbociclib.
Naloxone Injection Naloxone Injection The metabolism of Palbociclib can be decreased when combined with Naloxone.
Ambrisentan Ambrisentan The serum concentration of Ambrisentan can be increased when it is combined with Palbociclib.
Eculizumab Injection Eculizumab Injection The risk or severity of adverse effects can be increased when Eculizumab is combined with Palbociclib.
Fondaparinux Injection Fondaparinux Injection The risk or severity of bleeding can be increased when Fondaparinux is combined with Palbociclib.
Carfilzomib Injection Carfilzomib Injection The serum concentration of Palbociclib can be increased when it is combined with Carfilzomib.
Iloprost Iloprost The risk or severity of bleeding can be increased when Iloprost is combined with Palbociclib.
Enzalutamide Enzalutamide The metabolism of Palbociclib can be increased when combined with Enzalutamide.
Mirabegron Mirabegron The serum concentration of Palbociclib can be increased when it is combined with Mirabegron.
Regorafenib Regorafenib The metabolism of Palbociclib can be decreased when combined with Regorafenib.
Bosutinib Bosutinib The serum concentration of Bosutinib can be increased when it is combined with Palbociclib.
Corticotropin, Repository Injection Corticotropin, Repository Injection The metabolism of Palbociclib can be increased when combined with Corticotropin.
Teriflunomide Teriflunomide The risk or severity of adverse effects can be increased when Teriflunomide is combined with Palbociclib.
Icosapent Ethyl Icosapent Ethyl The risk or severity of bleeding can be increased when Icosapent ethyl is combined with Palbociclib.
Tofacitinib Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Palbociclib.
Dimethyl Fumarate Dimethyl Fumarate The risk or severity of adverse effects can be increased when Dimethyl fumarate is combined with Palbociclib.
Ponatinib Ponatinib The metabolism of Palbociclib can be decreased when combined with Ponatinib.
Pomalidomide Pomalidomide The serum concentration of Palbociclib can be increased when it is combined with Pomalidomide.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The serum concentration of Palbociclib can be increased when it is combined with Trastuzumab emtansine.
Apixaban Apixaban Palbociclib may decrease the excretion rate of Apixaban which could result in a higher serum level.
Canagliflozin Canagliflozin The serum concentration of Palbociclib can be increased when it is combined with Canagliflozin.
Dabrafenib Dabrafenib The serum concentration of Dabrafenib can be increased when it is combined with Palbociclib.
Trametinib Trametinib The metabolism of Palbociclib can be increased when combined with Trametinib.
Dolutegravir Dolutegravir Palbociclib may decrease the excretion rate of Dolutegravir which could result in a higher serum level.
Afatinib Afatinib The serum concentration of Afatinib can be increased when it is combined with Palbociclib.
Perampanel Perampanel The metabolism of Palbociclib can be increased when combined with Perampanel.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Palbociclib.
Lomitapide Lomitapide The metabolism of Lomitapide can be decreased when combined with Palbociclib.
Obinutuzumab Injection Obinutuzumab Injection The risk or severity of adverse effects can be increased when Obinutuzumab is combined with Palbociclib.
Simeprevir Simeprevir The metabolism of Palbociclib can be decreased when combined with Simeprevir.
Sofosbuvir Sofosbuvir Palbociclib may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Apremilast Apremilast The metabolism of Palbociclib can be increased when combined with Apremilast.
Ceritinib Ceritinib The serum concentration of Ceritinib can be increased when it is combined with Palbociclib.
Siltuximab Injection Siltuximab Injection The metabolism of Palbociclib can be increased when combined with Siltuximab.
Eslicarbazepine Eslicarbazepine The metabolism of Palbociclib can be increased when combined with Eslicarbazepine.
Vedolizumab Injection Vedolizumab Injection The risk or severity of adverse effects can be increased when Vedolizumab is combined with Palbociclib.
Belinostat Injection Belinostat Injection The risk or severity of adverse effects can be increased when Belinostat is combined with Palbociclib.
Idelalisib Idelalisib The metabolism of Idelalisib can be decreased when combined with Palbociclib.
Testosterone Injection Testosterone Injection The metabolism of Testosterone can be increased when combined with Palbociclib.
Oritavancin Injection Oritavancin Injection The metabolism of Palbociclib can be increased when combined with Oritavancin.
Vorapaxar Vorapaxar The metabolism of Vorapaxar can be decreased when combined with Palbociclib.
Suvorexant Suvorexant The metabolism of Suvorexant can be decreased when combined with Palbociclib.
Edoxaban Edoxaban The serum concentration of Edoxaban can be increased when it is combined with Palbociclib.
Peginterferon Beta-1a Injection Peginterferon Beta-1a Injection The risk or severity of adverse effects can be increased when Palbociclib is combined with Peginterferon beta-1a.
Olaparib Olaparib The metabolism of Olaparib can be decreased when combined with Palbociclib.
Blinatumomab Injection Blinatumomab Injection The risk or severity of adverse effects can be increased when Blinatumomab is combined with Palbociclib.
Tasimelteon Tasimelteon The metabolism of Palbociclib can be decreased when combined with Tasimelteon.
Riociguat Riociguat Palbociclib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Lanreotide Injection Lanreotide Injection The metabolism of Palbociclib can be decreased when combined with Lanreotide.
Pirfenidone Pirfenidone The risk or severity of adverse effects can be increased when Pirfenidone is combined with Palbociclib.
Nintedanib Nintedanib The metabolism of Nintedanib can be decreased when combined with Palbociclib.
Secukinumab Injection Secukinumab Injection The metabolism of Palbociclib can be increased when combined with Secukinumab.
Lenvatinib Lenvatinib The metabolism of Lenvatinib can be increased when combined with Palbociclib.
Naloxegol Naloxegol The serum concentration of Naloxegol can be increased when it is combined with Palbociclib.
Panobinostat Panobinostat The metabolism of Palbociclib can be decreased when combined with Panobinostat.
Dinutuximab Injection Dinutuximab Injection The risk or severity of adverse effects can be increased when Palbociclib is combined with Dinutuximab.
Haloperidol Injection Haloperidol Injection The serum concentration of Haloperidol can be increased when it is combined with Palbociclib.
Isavuconazonium Injection Isavuconazonium Injection The metabolism of Palbociclib can be increased when combined with Isavuconazonium.
Sonidegib Sonidegib The metabolism of Sonidegib can be decreased when combined with Palbociclib.
Rolapitant Rolapitant Rolapitant may decrease the excretion rate of Palbociclib which could result in a higher serum level.
Prednisolone Prednisolone The metabolism of Palbociclib can be increased when combined with Prednisolone.
Daclatasvir Daclatasvir Daclatasvir may decrease the excretion rate of Palbociclib which could result in a higher serum level.
Ziprasidone Injection Ziprasidone Injection The metabolism of Ziprasidone can be decreased when combined with Palbociclib.
Cobimetinib Cobimetinib The serum concentration of Cobimetinib can be increased when it is combined with Palbociclib.
Mepolizumab Injection Mepolizumab Injection The risk or severity of adverse effects can be increased when Mepolizumab is combined with Palbociclib.
Trabectedin Injection Trabectedin Injection The metabolism of Palbociclib can be decreased when combined with Trabectedin.
Osimertinib Osimertinib The metabolism of Osimertinib can be increased when combined with Palbociclib.
Alectinib Alectinib The metabolism of Palbociclib can be decreased when combined with Alectinib.
Ixazomib Ixazomib The metabolism of Ixazomib can be decreased when combined with Palbociclib.
Rifapentine Rifapentine The metabolism of Palbociclib can be increased when combined with Rifapentine.
Lesinurad Lesinurad The metabolism of Palbociclib can be increased when combined with Lesinurad.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The metabolism of Palbociclib can be decreased when combined with Amphotericin B.
Dexamethasone Injection Dexamethasone Injection The metabolism of Palbociclib can be increased when combined with Dexamethasone.
Defibrotide Injection Defibrotide Injection The risk or severity of bleeding can be increased when Defibrotide is combined with Palbociclib.
Ixekizumab Injection Ixekizumab Injection The risk or severity of adverse effects can be increased when Palbociclib is combined with Ixekizumab.
Venetoclax Venetoclax The metabolism of Venetoclax can be decreased when combined with Palbociclib.
Cobicistat Cobicistat The metabolism of Palbociclib can be decreased when combined with Cobicistat.
Selexipag Selexipag The serum concentration of Selexipag can be increased when it is combined with Palbociclib.
Rucaparib Rucaparib The metabolism of Rucaparib can be decreased when combined with Palbociclib.
Ribociclib Ribociclib The metabolism of Palbociclib can be decreased when combined with Ribociclib.
Brodalumab Injection Brodalumab Injection The risk or severity of adverse effects can be increased when Palbociclib is combined with Brodalumab.
Brigatinib Brigatinib The metabolism of Brigatinib can be increased when combined with Palbociclib.
Deflazacort Deflazacort The metabolism of Deflazacort can be increased when combined with Palbociclib.
Safinamide Safinamide Safinamide may decrease the excretion rate of Palbociclib which could result in a higher serum level.
Ocrelizumab Injection Ocrelizumab Injection The risk or severity of adverse effects can be increased when Palbociclib is combined with Ocrelizumab.
Sarilumab Injection Sarilumab Injection The metabolism of Sarilumab can be increased when combined with Palbociclib.
Midostaurin Midostaurin The metabolism of Palbociclib can be decreased when combined with Midostaurin.
Neratinib Neratinib The metabolism of Neratinib can be decreased when combined with Palbociclib.
Guselkumab Injection Guselkumab Injection The risk or severity of adverse effects can be increased when Palbociclib is combined with Guselkumab.
Enasidenib Enasidenib The metabolism of Enasidenib can be decreased when combined with Palbociclib.
Inotuzumab Ozogamicin Injection Inotuzumab Ozogamicin Injection The serum concentration of Inotuzumab ozogamicin can be increased when it is combined with Palbociclib.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Fosaprepitant can be increased when combined with Palbociclib.
Copanlisib Injection Copanlisib Injection The serum concentration of Copanlisib can be increased when it is combined with Palbociclib.
Delafloxacin Delafloxacin Palbociclib may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Abemaciclib Abemaciclib The metabolism of Abemaciclib can be decreased when combined with Palbociclib.
Betrixaban Betrixaban The serum concentration of Betrixaban can be increased when it is combined with Palbociclib.
Acalabrutinib Acalabrutinib The metabolism of Acalabrutinib can be decreased when combined with Palbociclib.
Gemtuzumab Ozogamicin Injection Gemtuzumab Ozogamicin Injection The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Palbociclib.
Letermovir Letermovir The metabolism of Palbociclib can be decreased when combined with Letermovir.
Ertugliflozin Ertugliflozin Palbociclib may decrease the excretion rate of Ertugliflozin which could result in a higher serum level.
Buprenorphine Injection Buprenorphine Injection The metabolism of Palbociclib can be decreased when combined with Buprenorphine.
Apalutamide Apalutamide The metabolism of Palbociclib can be increased when combined with Apalutamide.
Penicillamine Penicillamine The risk or severity of adverse effects can be increased when Penicillamine is combined with Palbociclib.
Fostamatinib Fostamatinib The metabolism of Palbociclib can be decreased when combined with Fostamatinib.
Avatrombopag Avatrombopag Avatrombopag may decrease the excretion rate of Palbociclib which could result in a higher serum level.
Baricitinib Baricitinib The metabolism of Baricitinib can be decreased when combined with Palbociclib.
Sodium Zirconium Cyclosilicate Sodium Zirconium Cyclosilicate The absorption of Palbociclib can be decreased when combined with Sodium zirconium cyclosilicate.
Eliglustat Eliglustat The metabolism of Eliglustat can be decreased when combined with Palbociclib.
Binimetinib Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Palbociclib.
Ivosidenib Ivosidenib The metabolism of Ivosidenib can be increased when combined with Palbociclib.
Lusutrombopag Lusutrombopag Palbociclib may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Elagolix Elagolix The serum concentration of Elagolix can be increased when it is combined with Palbociclib.
Cannabidiol Cannabidiol Cannabidiol may decrease the excretion rate of Palbociclib which could result in a higher serum level.
Dacomitinib Dacomitinib The serum concentration of Dacomitinib can be increased when it is combined with Palbociclib.
Duvelisib Duvelisib The metabolism of Duvelisib can be decreased when combined with Palbociclib.
Omadacycline Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Palbociclib.
Stiripentol Stiripentol The metabolism of Palbociclib can be decreased when combined with Stiripentol.
Talazoparib Talazoparib The serum concentration of Talazoparib can be increased when it is combined with Palbociclib.
Gilteritinib Gilteritinib The metabolism of Palbociclib can be decreased when combined with Gilteritinib.
Glasdegib Glasdegib Palbociclib may decrease the excretion rate of Glasdegib which could result in a higher serum level.
Larotrectinib Larotrectinib The serum concentration of Larotrectinib can be increased when it is combined with Palbociclib.
Methoxy Polyethylene Glycol-Epoetin Beta Injection Methoxy Polyethylene Glycol-Epoetin Beta Injection The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Palbociclib.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Palbociclib.
Rifamycin Rifamycin The metabolism of Rifamycin can be increased when combined with Palbociclib.
Prucalopride Prucalopride The serum concentration of Prucalopride can be increased when it is combined with Palbociclib.
Ravulizumab-cwvz Injection Ravulizumab-cwvz Injection The risk or severity of adverse effects can be increased when Palbociclib is combined with Ravulizumab.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Emapalumab can be increased when combined with Palbociclib.
Siponimod Siponimod The metabolism of Siponimod can be decreased when combined with Palbociclib.
Acyclovir Ophthalmic Acyclovir Ophthalmic The risk or severity of adverse effects can be increased when Palbociclib is combined with Acyclovir.
Caplacizumab-yhdp Injection Caplacizumab-yhdp Injection The risk or severity of bleeding can be increased when Caplacizumab is combined with Palbociclib.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Palbociclib.
Esomeprazole Injection Esomeprazole Injection The absorption of Palbociclib can be decreased when combined with Esomeprazole.
Risankizumab-rzaa Injection Risankizumab-rzaa Injection The risk or severity of adverse effects can be increased when Palbociclib is combined with Risankizumab.
Alpelisib Alpelisib The serum concentration of Alpelisib can be increased when it is combined with Palbociclib.
Cladribine Cladribine The risk or severity of adverse effects can be increased when Cladribine is combined with Palbociclib.
Darolutamide Darolutamide The serum concentration of Darolutamide can be increased when it is combined with Palbociclib.
Triclabendazole Triclabendazole The metabolism of Palbociclib can be decreased when combined with Triclabendazole.
Entrectinib Entrectinib The metabolism of Entrectinib can be decreased when combined with Palbociclib.
Pexidartinib Pexidartinib The metabolism of Pexidartinib can be decreased when combined with Palbociclib.
Istradefylline Istradefylline Istradefylline may decrease the excretion rate of Palbociclib which could result in a higher serum level.
Pitolisant Pitolisant The serum concentration of Palbociclib can be decreased when it is combined with Pitolisant.
Fedratinib Fedratinib Fedratinib may decrease the excretion rate of Palbociclib which could result in a higher serum level.
Lefamulin Lefamulin Palbociclib may decrease the excretion rate of Lefamulin which could result in a higher serum level.
Phenytoin Injection Phenytoin Injection The metabolism of Palbociclib can be increased when combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Fosphenytoin can be decreased when combined with Palbociclib.
Enfortumab vedotin-ejfv Injection Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be increased when it is combined with Palbociclib.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Palbociclib.
Voxelotor Voxelotor The serum concentration of Voxelotor can be increased when it is combined with Palbociclib.
Lasmiditan Lasmiditan The serum concentration of Palbociclib can be increased when it is combined with Lasmiditan.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Palbociclib.
Tazemetostat Tazemetostat The metabolism of Tazemetostat can be decreased when combined with Palbociclib.
Cenobamate Cenobamate The serum concentration of Palbociclib can be decreased when it is combined with Cenobamate.
Ozanimod Ozanimod Palbociclib may decrease the excretion rate of Ozanimod which could result in a higher serum level.
Selumetinib Selumetinib Palbociclib may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Rimegepant Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Palbociclib.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Palbociclib.
Remdesivir Injection Remdesivir Injection The serum concentration of Remdesivir can be increased when it is combined with Palbociclib.
Ripretinib Ripretinib Palbociclib may decrease the excretion rate of Ripretinib which could result in a higher serum level.
Capmatinib Capmatinib The serum concentration of Palbociclib can be increased when it is combined with Capmatinib.
Lemborexant Lemborexant The serum concentration of Lemborexant can be increased when it is combined with Palbociclib.
Fostemsavir Fostemsavir Palbociclib may decrease the excretion rate of Fostemsavir which could result in a higher serum level.
Octreotide Octreotide The serum concentration of Palbociclib can be increased when it is combined with Octreotide.
Belantamab Mafodotin-blmf Injection Belantamab Mafodotin-blmf Injection The serum concentration of Belantamab mafodotin can be increased when it is combined with Palbociclib.
Pralsetinib Pralsetinib The serum concentration of Pralsetinib can be increased when it is combined with Palbociclib.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Palbociclib can be decreased when it is combined with Satralizumab.
Relugolix Relugolix The serum concentration of Relugolix can be increased when it is combined with Palbociclib.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Drospirenone can be decreased when combined with Palbociclib.
Vitamin E (Alpha-Tocopherol) Vitamin E (Alpha-Tocopherol) The metabolism of Palbociclib can be increased when combined with Vitamin E.
Theophylline Theophylline The metabolism of Theophylline can be decreased when combined with Palbociclib.
Indomethacin Indomethacin The risk or severity of adverse effects can be increased when Indomethacin is combined with Palbociclib.
Sodium Bicarbonate Sodium Bicarbonate The absorption of Palbociclib can be decreased when combined with Sodium bicarbonate.
Hydroxyurea Hydroxyurea The risk or severity of adverse effects can be increased when Hydroxyurea is combined with Palbociclib.
Floxuridine Floxuridine The risk or severity of adverse effects can be increased when Floxuridine is combined with Palbociclib.
Phenobarbital Phenobarbital The metabolism of Palbociclib can be increased when combined with Phenobarbital.
Methotrexate Injection Methotrexate Injection The metabolism of Palbociclib can be decreased when combined with Methotrexate.
Primidone Primidone The metabolism of Palbociclib can be increased when combined with Primidone.
Chlorpromazine Chlorpromazine The metabolism of Chlorpromazine can be increased when combined with Palbociclib.
Diazepam Diazepam The metabolism of Palbociclib can be decreased when combined with Diazepam.
Lorazepam Lorazepam The metabolism of Palbociclib can be decreased when combined with Lorazepam.
Carmustine Carmustine The risk or severity of adverse effects can be increased when Carmustine is combined with Palbociclib.
Amantadine Amantadine The risk or severity of adverse effects can be increased when Palbociclib is combined with Amantadine.
Codeine Codeine The risk or severity of adverse effects can be increased when Palbociclib is combined with Codeine.
Bromocriptine Bromocriptine The metabolism of Palbociclib can be decreased when combined with Bromocriptine.
Tranylcypromine Tranylcypromine The metabolism of Palbociclib can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine The metabolism of Palbociclib can be decreased when combined with Phenelzine.
Procarbazine Procarbazine The risk or severity of adverse effects can be increased when Procarbazine is combined with Palbociclib.
Tetracycline Tetracycline The metabolism of Palbociclib can be decreased when combined with Tetracycline.
Thioguanine Thioguanine The risk or severity of adverse effects can be increased when Tioguanine is combined with Palbociclib.
Prochlorperazine Prochlorperazine The metabolism of Palbociclib can be decreased when combined with Prochlorperazine.
Bleomycin Bleomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Palbociclib.
Methadone Methadone The metabolism of Palbociclib can be increased when combined with Methadone.
Oxybutynin Oxybutynin The metabolism of Palbociclib can be decreased when combined with Oxybutynin.
Orphenadrine Orphenadrine The metabolism of Palbociclib can be decreased when combined with Orphenadrine.
Azathioprine Azathioprine The risk or severity of adverse effects can be increased when Azathioprine is combined with Palbociclib.
Phentermine Phentermine The metabolism of Palbociclib can be decreased when combined with Phentermine.
Sulfasalazine Sulfasalazine The risk or severity of adverse effects can be increased when Sulfasalazine is combined with Palbociclib.
Hydrocortisone Hydrocortisone The metabolism of Palbociclib can be increased when combined with Hydrocortisone.
Lomustine Lomustine The risk or severity of adverse effects can be increased when Lomustine is combined with Palbociclib.
Doxorubicin Doxorubicin The serum concentration of Doxorubicin can be increased when it is combined with Palbociclib.
Cytarabine Cytarabine The risk or severity of adverse effects can be increased when Cytarabine is combined with Palbociclib.
Mechlorethamine Mechlorethamine The risk or severity of adverse effects can be increased when Mechlorethamine is combined with Palbociclib.
Dactinomycin Dactinomycin The serum concentration of Palbociclib can be increased when it is combined with Dactinomycin.
Carbamazepine Carbamazepine The metabolism of Carbamazepine can be decreased when combined with Palbociclib.
Clonidine Clonidine The metabolism of Clonidine can be decreased when combined with Palbociclib.
Prazosin Prazosin Palbociclib may decrease the excretion rate of Prazosin which could result in a higher serum level.
Hydralazine Hydralazine The metabolism of Palbociclib can be decreased when combined with Hydralazine.
Cimetidine Cimetidine The absorption of Palbociclib can be decreased when combined with Cimetidine.
Warfarin Warfarin The serum concentration of Warfarin can be increased when it is combined with Palbociclib.
Loperamide Loperamide The metabolism of Palbociclib can be decreased when combined with Loperamide.
Daunorubicin Daunorubicin The metabolism of Palbociclib can be decreased when combined with Daunorubicin.
Nitrofurantoin Nitrofurantoin Palbociclib may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Griseofulvin Griseofulvin The metabolism of Palbociclib can be increased when combined with Griseofulvin.
Digoxin Digoxin Palbociclib may decrease the excretion rate of Digoxin which could result in a higher serum level.
Quinine Quinine The metabolism of Palbociclib can be increased when combined with Quinine.
Calcitriol Calcitriol The metabolism of Palbociclib can be increased when combined with Calcitriol.
Sulfinpyrazone Sulfinpyrazone The metabolism of Palbociclib can be increased when combined with Sulfinpyrazone.
Chlorothiazide Chlorothiazide The risk or severity of neutropenia and thrombocytopenia can be increased when Chlorothiazide is combined with Palbociclib.
Secobarbital Secobarbital The metabolism of Palbociclib can be increased when combined with Secobarbital.
Desipramine Desipramine The metabolism of Desipramine can be decreased when combined with Palbociclib.
Imipramine Imipramine The serum concentration of Imipramine can be increased when it is combined with Palbociclib.
Probenecid Probenecid The metabolism of Palbociclib can be increased when combined with Probenecid.
Quinidine Quinidine The serum concentration of Quinidine can be increased when it is combined with Palbociclib.
Isoniazid Isoniazid The metabolism of Palbociclib can be decreased when combined with Isoniazid.
Rifampin Rifampin The metabolism of Palbociclib can be increased when combined with Rifampicin.
Valproic Acid Valproic Acid The metabolism of Palbociclib can be decreased when combined with Valproic acid.
Tamoxifen Tamoxifen The metabolism of Tamoxifen can be increased when combined with Palbociclib.
Mitomycin Mitomycin The risk or severity of adverse effects can be increased when Mitomycin is combined with Palbociclib.
Methimazole Methimazole The metabolism of Palbociclib can be decreased when combined with Methimazole.
Propylthiouracil Propylthiouracil The risk or severity of adverse effects can be increased when Propylthiouracil is combined with Palbociclib.
Niacin Niacin The metabolism of Palbociclib can be decreased when combined with Niacin.
Methyclothiazide Methyclothiazide The risk or severity of neutropenia and thrombocytopenia can be increased when Methyclothiazide is combined with Palbociclib.
Hydrochlorothiazide Hydrochlorothiazide The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Palbociclib.
Folic Acid Folic Acid Palbociclib may decrease the excretion rate of Folic acid which could result in a higher serum level.
Danazol Danazol The metabolism of Palbociclib can be decreased when combined with Danazol.
Nortriptyline Nortriptyline The serum concentration of Nortriptyline can be increased when it is combined with Palbociclib.
Amphotericin B Injection Amphotericin B Injection The metabolism of Palbociclib can be decreased when combined with Amphotericin B.
Mercaptopurine Mercaptopurine The risk or severity of adverse effects can be increased when Mercaptopurine is combined with Palbociclib.
Allopurinol Allopurinol The risk or severity of adverse effects can be increased when Allopurinol is combined with Palbociclib.
Clomiphene Clomiphene The serum concentration of Clomifene can be increased when it is combined with Palbociclib.
Fluorouracil Injection Fluorouracil Injection The risk or severity of adverse effects can be increased when Fluorouracil is combined with Palbociclib.
Colchicine Colchicine The metabolism of Colchicine can be decreased when combined with Palbociclib.
Cephalexin Cephalexin The metabolism of Palbociclib can be decreased when combined with Cephalexin.
Dacarbazine Dacarbazine The risk or severity of adverse effects can be increased when Dacarbazine is combined with Palbociclib.
Acetazolamide Acetazolamide The metabolism of Palbociclib can be decreased when combined with Acetazolamide.
Bacillus Calmette-Guerin (BCG) Vaccine Bacillus Calmette-Guerin (BCG) Vaccine The risk or severity of infection can be increased when Bacillus calmette-guerin substrain tice live antigen is combined with Palbociclib.
Ketoconazole Ketoconazole The metabolism of Palbociclib can be decreased when combined with Ketoconazole.
Thiotepa Injection Thiotepa Injection The metabolism of Palbociclib can be decreased when combined with Thiotepa.
Vincristine Injection Vincristine Injection The excretion of Vincristine can be decreased when combined with Palbociclib.
Dipyridamole Dipyridamole The risk or severity of bleeding can be increased when Dipyridamole is combined with Palbociclib.
Vinblastine Vinblastine The metabolism of Palbociclib can be decreased when combined with Vinblastine.
Metoprolol Metoprolol The metabolism of Metoprolol can be decreased when combined with Palbociclib.
Aspirin Aspirin The risk or severity of bleeding can be increased when Acetylsalicylic acid is combined with Palbociclib.
Chlorambucil Chlorambucil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Palbociclib.
Alprazolam Alprazolam The metabolism of Alprazolam can be decreased when combined with Palbociclib.
Diltiazem Diltiazem The metabolism of Palbociclib can be decreased when combined with Diltiazem.
Nifedipine Nifedipine The metabolism of Palbociclib can be increased when combined with Nifedipine.
Verapamil Verapamil The metabolism of Verapamil can be decreased when combined with Palbociclib.
Cisplatin Injection Cisplatin Injection The risk or severity of adverse effects can be increased when Cisplatin is combined with Palbociclib.
Streptozocin Streptozocin The risk or severity of adverse effects can be increased when Streptozocin is combined with Palbociclib.
Etoposide Etoposide The serum concentration of Palbociclib can be increased when it is combined with Etoposide.
Glyburide Glyburide The metabolism of Glyburide can be decreased when combined with Palbociclib.
Dicloxacillin Dicloxacillin The metabolism of Palbociclib can be increased when combined with Dicloxacillin.
Nafcillin Injection Nafcillin Injection The metabolism of Palbociclib can be increased when combined with Nafcillin.
Pentoxifylline Pentoxifylline The risk or severity of bleeding can be increased when Pentoxifylline is combined with Palbociclib.
Pimozide Pimozide The metabolism of Pimozide can be decreased when combined with Palbociclib.
Amiodarone Amiodarone The metabolism of Amiodarone can be decreased when combined with Palbociclib.
Lovastatin Lovastatin The metabolism of Lovastatin can be decreased when combined with Palbociclib.
Ciprofloxacin Ciprofloxacin The metabolism of Palbociclib can be decreased when combined with Ciprofloxacin.
Interferon Alfa-2b Injection Interferon Alfa-2b Injection The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Palbociclib.
Clozapine Clozapine The risk or severity of neutropenia can be increased when Palbociclib is combined with Clozapine.
Idarubicin Idarubicin The risk or severity of adverse effects can be increased when Idarubicin is combined with Palbociclib.
Fludarabine Injection Fludarabine Injection The risk or severity of adverse effects can be increased when Fludarabine is combined with Palbociclib.
Pentostatin Injection Pentostatin Injection The risk or severity of adverse effects can be increased when Pentostatin is combined with Palbociclib.
Clarithromycin Clarithromycin The metabolism of Palbociclib can be decreased when combined with Clarithromycin.
Felodipine Felodipine The metabolism of Palbociclib can be decreased when combined with Felodipine.
Pravastatin Pravastatin Pravastatin may decrease the excretion rate of Palbociclib which could result in a higher serum level.
Simvastatin Simvastatin The serum concentration of Palbociclib can be increased when it is combined with Simvastatin.
Epoetin Alfa, Injection Epoetin Alfa, Injection The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Palbociclib.
Teniposide Injection Teniposide Injection The metabolism of Palbociclib can be decreased when combined with Teniposide.
Itraconazole Itraconazole The metabolism of Palbociclib can be decreased when combined with Itraconazole.
Rifabutin Rifabutin The metabolism of Palbociclib can be increased when combined with Rifabutin.
Bisoprolol Bisoprolol The serum concentration of Bisoprolol can be increased when it is combined with Palbociclib.
Doxazosin Doxazosin The metabolism of Doxazosin can be decreased when combined with Palbociclib.
Isradipine Isradipine The metabolism of Palbociclib can be decreased when combined with Isradipine.
Omeprazole Omeprazole The absorption of Palbociclib can be decreased when combined with Omeprazole.
Cisapride Cisapride The metabolism of Palbociclib can be decreased when combined with Cisapride.
Fluvastatin Fluvastatin The metabolism of Palbociclib can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine Venlafaxine may increase the excretion rate of Palbociclib which could result in a lower serum level and potentially a reduction in efficacy.
Nizatidine Nizatidine The absorption of Palbociclib can be decreased when combined with Nizatidine.
Famciclovir Famciclovir The metabolism of Palbociclib can be decreased when combined with Famciclovir.
Fluvoxamine Fluvoxamine The metabolism of Palbociclib can be decreased when combined with Fluvoxamine.
Nefazodone Nefazodone The metabolism of Palbociclib can be decreased when combined with Nefazodone.
Losartan Losartan The metabolism of Palbociclib can be decreased when combined with Losartan.
Tramadol Tramadol The metabolism of Tramadol can be decreased when combined with Palbociclib.
Vinorelbine Injection Vinorelbine Injection The metabolism of Palbociclib can be decreased when combined with Vinorelbine.
Carboplatin Injection Carboplatin Injection The risk or severity of adverse effects can be increased when Carboplatin is combined with Palbociclib.
Lansoprazole Lansoprazole The absorption of Palbociclib can be decreased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The metabolism of Palbociclib can be increased when combined with Ifosfamide.
Pegaspargase Injection Pegaspargase Injection The risk or severity of adverse effects can be increased when Pegaspargase is combined with Palbociclib.
Nicardipine Nicardipine The metabolism of Palbociclib can be decreased when combined with Nicardipine.
Ticlopidine Ticlopidine The metabolism of Palbociclib can be decreased when combined with Ticlopidine.
Saquinavir Saquinavir The metabolism of Saquinavir can be decreased when combined with Palbociclib.
Metformin Metformin The risk or severity of adverse effects can be increased when Palbociclib is combined with Metformin.
Dalteparin Injection Dalteparin Injection The risk or severity of bleeding can be increased when Dalteparin is combined with Palbociclib.
Lamivudine Lamivudine Palbociclib may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Riluzole Riluzole Palbociclib may decrease the excretion rate of Riluzole which could result in a higher serum level.
Gemcitabine Injection Gemcitabine Injection The serum concentration of Palbociclib can be increased when it is combined with Gemcitabine.
Ritonavir Ritonavir The metabolism of Palbociclib can be decreased when combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Palbociclib can be decreased when combined with Docetaxel.
Clomipramine Clomipramine The metabolism of Clomipramine can be decreased when combined with Palbociclib.
Zafirlukast Zafirlukast The metabolism of Palbociclib can be decreased when combined with Zafirlukast.
Mirtazapine Mirtazapine The metabolism of Palbociclib can be decreased when combined with Mirtazapine.
Topiramate Topiramate The metabolism of Palbociclib can be increased when combined with Topiramate.
Pramipexole Pramipexole The risk or severity of adverse effects can be increased when Palbociclib is combined with Pramipexole.
Donepezil Donepezil Palbociclib may decrease the excretion rate of Donepezil which could result in a higher serum level.
Nelfinavir Nelfinavir Nelfinavir may decrease the excretion rate of Palbociclib which could result in a higher serum level.
Fexofenadine Fexofenadine The serum concentration of Palbociclib can be increased when it is combined with Fexofenadine.
Azithromycin Azithromycin The metabolism of Azithromycin can be decreased when combined with Palbociclib.
Bicalutamide Bicalutamide The metabolism of Palbociclib can be decreased when combined with Bicalutamide.
Raloxifene Raloxifene The metabolism of Raloxifene can be decreased when combined with Palbociclib.
Irbesartan Irbesartan The metabolism of Palbociclib can be decreased when combined with Irbesartan.
Paroxetine Paroxetine The metabolism of Palbociclib can be decreased when combined with Paroxetine.
Citalopram Citalopram The metabolism of Palbociclib can be decreased when combined with Citalopram.
Capecitabine Capecitabine The risk or severity of adverse effects can be increased when Capecitabine is combined with Palbociclib.
Efavirenz Efavirenz The metabolism of Palbociclib can be decreased when combined with Efavirenz.
Sildenafil Sildenafil The serum concentration of Palbociclib can be increased when it is combined with Sildenafil.
Trastuzumab Injection Trastuzumab Injection Trastuzumab may increase the neutropenic activities of Palbociclib.
Celecoxib Celecoxib Palbociclib may decrease the excretion rate of Celecoxib which could result in a higher serum level.
Thalidomide Thalidomide The risk or severity of adverse effects can be increased when Thalidomide is combined with Palbociclib.
Aluminum Hydroxide Aluminum Hydroxide The absorption of Palbociclib can be decreased when combined with Aluminum hydroxide.
Rabeprazole Rabeprazole The absorption of Palbociclib can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Palbociclib can be increased when combined with Terbinafine.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists