Ospemifene

Generic name: Pronounced as (os pem' i feen)
Brand names
  • Osphena®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 05/15/2019

Taking ospemifene may increase the risk that you will develop endometrial cancer (cancer of the uterus [womb]). Tell your doctor if you have or have ever had cancer or if you have abnormal vaginal bleeding. Your doctor will probably tell you not to take ospemifene. If you have any unusual vaginal bleeding while you are taking ospemifene call your doctor immediately.

Taking ospemifene also may increase the risk of stroke and blood clots. Tell your doctor if you smoke or if you have ever had a stroke; if you or anyone in your family has or has ever had blood clots; or if you have or have ever had high blood pressure, high blood levels of cholesterol or fats, diabetes, heart disease, or lupus (a condition in which the body attacks its own tissues causing damage and swelling). Your doctor will probably tell you not to take ospemifene. Talk to your doctor every 3 to 6 months to discuss if you should continue taking this medication. If you experience any of the following symptoms, stop taking ospemifene and call your doctor immediately: swelling or pain in your legs; warm or red skin; slow or difficult speech; dizziness or faintness; weakness or numbness of an arm or leg; sudden, severe headache; sudden changes in vision; pain in your chest, arms, back, neck or jaw; or shortness of breath.

Keep all appointments with your doctor and the laboratory. Your doctor may order certain tests to check your body's response to ospemifene.

Talk to your doctor about the risks and benefits of taking this medication.

Ospemifene is used to treat changes due to menopause (''change of life,'' the end of monthly menstrual periods) in and around the vagina that can cause painful sexual intercourse and vaginal dryness. Ospemifene is in a class of medications called hormones. It works by replacing estrogen that is normally produced by the body.

Ospemifene comes as a tablet to take by mouth. It is usually taken with food once daily. Take ospemifene at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take ospemifene exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Ospemifene helps to control the symptoms of menopause that can cause vaginal dryness and pain during intercourse but does not cure it. Continue to take ospemifene even if you feel well. Do not stop taking ospemifene without talking to your doctor.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking ospemifene,

  • tell your doctor and pharmacist if you are allergic to ospemifene, any other medications, or any of the ingredients in ospemifene tablets. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antifungals such as itraconazole (Sporanox), fluconazole (Diflucan), ketoconazole (Nizoral); clarithromycin (Biaxin); estrogens such as (Premarin); estrogen agonists/antagonists such as tamoxifen (Nolvadex); medications for human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) such as indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), saquinavir (Fortovase, Invirase); nefazodone; or rifampin (Rifadin, Rimactane, in Rifamate). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you have or have ever had liver disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or are feeding. Ospemifene may cause fetal harm. If you become pregnant while taking ospemifene, call your doctor immediately.

  • if you are having surgery, including dental surgery, or will be on bed rest, tell the doctor or dentist you are taking ospemifene.

Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medication.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Ospemifene may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • hot flashes or flushes

    • vaginal discharge

    • muscle spasms

    • increased sweating

  • Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:

    • swelling of the face, throat, tongue, lips. eyes, hands, feet, ankles, or lower legs

    • hoarseness

    • difficulty swallowing or breathing

    • hives

    • rash

    • itching

  • Ospemifene may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Montelukast Montelukast The metabolism of Ospemifene can be decreased when combined with Montelukast.
Leflunomide Leflunomide The metabolism of Ospemifene can be decreased when combined with Leflunomide.
Delavirdine Delavirdine The metabolism of Ospemifene can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Ospemifene can be increased when combined with Nevirapine.
Dolasetron Dolasetron The metabolism of Dolasetron can be decreased when combined with Ospemifene.
Candesartan Candesartan The metabolism of Ospemifene can be decreased when combined with Candesartan.
Cilostazol Cilostazol The metabolism of Cilostazol can be decreased when combined with Ospemifene.
Clopidogrel Clopidogrel The metabolism of Ospemifene can be decreased when combined with Clopidogrel.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) The risk or severity of adverse effects can be increased when Conjugated estrogens is combined with Ospemifene.
Fenofibrate Fenofibrate The metabolism of Ospemifene can be decreased when combined with Fenofibrate.
Penbutolol Penbutolol The metabolism of Acebutolol can be decreased when combined with Ospemifene.
Fluconazole Injection Fluconazole Injection The metabolism of Ospemifene can be decreased when combined with Fluconazole.
Hydromorphone Injection Hydromorphone Injection The metabolism of Ospemifene can be decreased when combined with Hydromorphone.
Meperidine Injection Meperidine Injection The metabolism of Ospemifene can be decreased when combined with Meperidine.
Metoclopramide Injection Metoclopramide Injection The metabolism of Metoclopramide can be decreased when combined with Ospemifene.
Metronidazole Injection Metronidazole Injection The metabolism of Ospemifene can be decreased when combined with Metronidazole.
Zidovudine Injection Zidovudine Injection The metabolism of Ospemifene can be decreased when combined with Zidovudine.
Altretamine Altretamine The metabolism of Amphetamine can be decreased when combined with Ospemifene.
Ondansetron Ondansetron The metabolism of Ospemifene can be decreased when combined with Ondansetron.
Torsemide Torsemide The metabolism of Ospemifene can be decreased when combined with Torasemide.
Olanzapine Olanzapine The metabolism of Ospemifene can be decreased when combined with Olanzapine.
Alosetron Alosetron The metabolism of Ospemifene can be decreased when combined with Alosetron.
Hydroxychloroquine Hydroxychloroquine The metabolism of Hydroxychloroquine can be decreased when combined with Ospemifene.
Meloxicam Meloxicam The metabolism of Ospemifene can be decreased when combined with Meloxicam.
Anakinra Anakinra The metabolism of Ospemifene can be increased when combined with Anakinra.
Trimipramine Trimipramine The metabolism of Ospemifene can be decreased when combined with Trimipramine.
Etanercept Injection Etanercept Injection The metabolism of Ospemifene can be increased when combined with Etanercept.
Modafinil Modafinil The metabolism of Ospemifene can be decreased when combined with Modafinil.
Epinephrine Injection Epinephrine Injection The metabolism of Ospemifene can be decreased when combined with Epinephrine.
Escitalopram Escitalopram The metabolism of Escitalopram can be decreased when combined with Ospemifene.
Adalimumab Injection Adalimumab Injection The metabolism of Ospemifene can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Ospemifene.
Atomoxetine Atomoxetine The metabolism of Atomoxetine can be decreased when combined with Ospemifene.
Atazanavir Atazanavir The metabolism of Ospemifene can be decreased when combined with Atazanavir.
Almotriptan Almotriptan The metabolism of Almotriptan can be decreased when combined with Ospemifene.
Eletriptan Eletriptan The metabolism of Ospemifene can be decreased when combined with Eletriptan.
Rosuvastatin Rosuvastatin The metabolism of Ospemifene can be decreased when combined with Rosuvastatin.
Aprepitant Aprepitant The metabolism of Ospemifene can be decreased when combined with Aprepitant.
Memantine Memantine The metabolism of Ospemifene can be decreased when combined with Memantine.
Tegaserod Tegaserod The metabolism of Tegaserod can be decreased when combined with Ospemifene.
Progesterone Progesterone The metabolism of Ospemifene can be decreased when combined with Progesterone.
Apomorphine Injection Apomorphine Injection The metabolism of Ospemifene can be decreased when combined with Apomorphine.
Infliximab Injection Infliximab Injection The metabolism of Ospemifene can be increased when combined with Infliximab.
Oxandrolone Oxandrolone The metabolism of Ospemifene can be decreased when combined with Oxandrolone.
Protriptyline Protriptyline The metabolism of Protriptyline can be decreased when combined with Ospemifene.
Duloxetine Duloxetine The metabolism of Ospemifene can be decreased when combined with Duloxetine.
Bosentan Bosentan The metabolism of Ospemifene can be increased when combined with Bosentan.
Erlotinib Erlotinib The metabolism of Erlotinib can be decreased when combined with Ospemifene.
Solifenacin Solifenacin The metabolism of Solifenacin can be decreased when combined with Ospemifene.
Voriconazole Voriconazole The metabolism of Ospemifene can be decreased when combined with Voriconazole.
Dextroamphetamine Dextroamphetamine The metabolism of Amphetamine can be decreased when combined with Ospemifene.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The metabolism of Ospemifene can be increased when combined with Peginterferon alfa-2b.
Ramelteon Ramelteon The metabolism of Ospemifene can be decreased when combined with Ramelteon.
Darifenacin Darifenacin The metabolism of Darifenacin can be decreased when combined with Ospemifene.
Tipranavir Tipranavir The metabolism of Tipranavir can be decreased when combined with Ospemifene.
Felbamate Felbamate The metabolism of Ospemifene can be decreased when combined with Felbamate.
Ranolazine Ranolazine The metabolism of Ranolazine can be decreased when combined with Ospemifene.
Abatacept Injection Abatacept Injection The metabolism of Ospemifene can be increased when combined with Abatacept.
Imatinib Imatinib The metabolism of Ospemifene can be decreased when combined with Imatinib.
Gefitinib Gefitinib The metabolism of Ospemifene can be decreased when combined with Gefitinib.
Paliperidone Paliperidone The metabolism of Paliperidone can be decreased when combined with Ospemifene.
Bortezomib Bortezomib The metabolism of Ospemifene can be decreased when combined with Bortezomib.
Fulvestrant Injection Fulvestrant Injection The risk or severity of adverse effects can be increased when Fulvestrant is combined with Ospemifene.
Lisdexamfetamine Lisdexamfetamine The metabolism of Lisdexamfetamine can be decreased when combined with Ospemifene.
Nabilone Nabilone The metabolism of Ospemifene can be decreased when combined with Nabilone.
Sorafenib Sorafenib The metabolism of Ospemifene can be decreased when combined with Sorafenib.
Dronabinol Dronabinol The metabolism of Ospemifene can be decreased when combined with Dronabinol.
Mexiletine Mexiletine The metabolism of Ospemifene can be decreased when combined with Mexiletine.
Armodafinil Armodafinil The metabolism of Ospemifene can be decreased when combined with Armodafinil.
Nilotinib Nilotinib The metabolism of Ospemifene can be decreased when combined with Nilotinib.
Toremifene Toremifene The risk or severity of adverse effects can be increased when Toremifene is combined with Ospemifene.
Bexarotene Bexarotene The metabolism of Ospemifene can be decreased when combined with Bexarotene.
Etravirine Etravirine The metabolism of Ospemifene can be decreased when combined with Etravirine.
Cevimeline Cevimeline The metabolism of Cevimeline can be decreased when combined with Ospemifene.
Nebivolol Nebivolol The metabolism of Nebivolol can be decreased when combined with Ospemifene.
Tretinoin Tretinoin The metabolism of Ospemifene can be decreased when combined with Tretinoin.
Flecainide Flecainide The metabolism of Ospemifene can be decreased when combined with Flecainide.
Certolizumab Injection Certolizumab Injection The metabolism of Ospemifene can be increased when combined with Certolizumab pegol.
Irinotecan Injection Irinotecan Injection The metabolism of Ospemifene can be decreased when combined with Irinotecan.
Fesoterodine Fesoterodine The metabolism of Fesoterodine can be decreased when combined with Ospemifene.
Betaxolol Betaxolol The metabolism of Betaxolol can be decreased when combined with Ospemifene.
Iloperidone Iloperidone The metabolism of Iloperidone can be decreased when combined with Ospemifene.
Prasugrel Prasugrel The metabolism of Prasugrel can be decreased when combined with Ospemifene.
Lacosamide Lacosamide The metabolism of Lacosamide can be decreased when combined with Ospemifene.
Palonosetron Injection Palonosetron Injection The metabolism of Palonosetron can be decreased when combined with Ospemifene.
Romidepsin Injection Romidepsin Injection The metabolism of Romidepsin can be decreased when combined with Ospemifene.
Tapentadol Tapentadol The metabolism of Tapentadol can be decreased when combined with Ospemifene.
Golimumab Injection Golimumab Injection The metabolism of Ospemifene can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Pazopanib can be decreased when combined with Ospemifene.
Pitavastatin Pitavastatin The metabolism of Pitavastatin can be decreased when combined with Ospemifene.
Oxymorphone Oxymorphone The metabolism of Oxymorphone can be decreased when combined with Ospemifene.
Tocilizumab Injection Tocilizumab Injection The metabolism of Ospemifene can be increased when combined with Tocilizumab.
Acetaminophen Injection Acetaminophen Injection The metabolism of Acetaminophen can be decreased when combined with Ospemifene.
Vilazodone Vilazodone The metabolism of Vilazodone can be decreased when combined with Ospemifene.
Rilpivirine Rilpivirine The metabolism of Ospemifene can be decreased when combined with Rilpivirine.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Ospemifene can be decreased when combined with Cyclophosphamide.
Abiraterone Abiraterone The metabolism of Ospemifene can be decreased when combined with Abiraterone.
Ticagrelor Ticagrelor The metabolism of Ospemifene can be decreased when combined with Ticagrelor.
Clobazam Clobazam The metabolism of Ospemifene can be decreased when combined with Clobazam.
Vemurafenib Vemurafenib The metabolism of Ospemifene can be decreased when combined with Vemurafenib.
Vismodegib Vismodegib The metabolism of Ospemifene can be decreased when combined with Vismodegib.
Enzalutamide Enzalutamide The metabolism of Ospemifene can be decreased when combined with Enzalutamide.
Mirabegron Mirabegron The metabolism of Mirabegron can be decreased when combined with Ospemifene.
Regorafenib Regorafenib The metabolism of Ospemifene can be decreased when combined with Regorafenib.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Ospemifene.
Alogliptin Alogliptin The metabolism of Alogliptin can be decreased when combined with Ospemifene.
Ponatinib Ponatinib The metabolism of Ponatinib can be decreased when combined with Ospemifene.
Apixaban Apixaban The metabolism of Apixaban can be decreased when combined with Ospemifene.
Dabrafenib Dabrafenib The metabolism of Ospemifene can be increased when combined with Dabrafenib.
Levomilnacipran Levomilnacipran The metabolism of Levomilnacipran can be decreased when combined with Ospemifene.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Ospemifene.
Perampanel Perampanel The metabolism of Perampanel can be decreased when combined with Ospemifene.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Ospemifene.
Ketorolac Injection Ketorolac Injection The metabolism of Ospemifene can be decreased when combined with Ketorolac.
Dapagliflozin Dapagliflozin The metabolism of Dapagliflozin can be decreased when combined with Ospemifene.
Apremilast Apremilast The metabolism of Ospemifene can be increased when combined with Apremilast.
Ceritinib Ceritinib The metabolism of Ospemifene can be decreased when combined with Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Ospemifene can be increased when combined with Siltuximab.
Testosterone Injection Testosterone Injection The metabolism of Ospemifene can be decreased when combined with Testosterone.
Oritavancin Injection Oritavancin Injection The metabolism of Ospemifene can be decreased when combined with Oritavancin.
Hydrocodone Hydrocodone The metabolism of Ospemifene can be decreased when combined with Hydrocodone.
Olaparib Olaparib The metabolism of Olaparib can be increased when combined with Ospemifene.
Methamphetamine Methamphetamine The metabolism of Metamfetamine can be decreased when combined with Ospemifene.
Secukinumab Injection Secukinumab Injection The metabolism of Ospemifene can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The metabolism of Risperidone can be decreased when combined with Ospemifene.
Lenvatinib Lenvatinib The metabolism of Ospemifene can be decreased when combined with Lenvatinib.
Haloperidol Injection Haloperidol Injection The serum concentration of Ospemifene can be increased when it is combined with Haloperidol.
Brexpiprazole Brexpiprazole The metabolism of Brexpiprazole can be decreased when combined with Ospemifene.
Cariprazine Cariprazine The metabolism of Cariprazine can be decreased when combined with Ospemifene.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Ospemifene.
Rifapentine Rifapentine The metabolism of Ospemifene can be increased when combined with Rifapentine.
Lesinurad Lesinurad The metabolism of Lesinurad can be decreased when combined with Ospemifene.
Dexamethasone Injection Dexamethasone Injection The metabolism of Ospemifene can be increased when combined with Dexamethasone.
Brivaracetam Injection Brivaracetam Injection The metabolism of Brivaracetam can be decreased when combined with Ospemifene.
Diphenhydramine Injection Diphenhydramine Injection The metabolism of Ospemifene can be decreased when combined with Diphenhydramine.
Rucaparib Rucaparib The metabolism of Ospemifene can be decreased when combined with Rucaparib.
Doxepin (Insomnia) Doxepin (Insomnia) The metabolism of Ospemifene can be decreased when combined with Doxepin.
Deutetrabenazine Deutetrabenazine The metabolism of Deutetrabenazine can be decreased when combined with Ospemifene.
Valbenazine Valbenazine The metabolism of Valbenazine can be decreased when combined with Ospemifene.
Safinamide Safinamide The metabolism of Ospemifene can be decreased when combined with Safinamide.
Midostaurin Midostaurin The metabolism of Ospemifene can be decreased when combined with Midostaurin.
Enasidenib Enasidenib The metabolism of Enasidenib can be decreased when combined with Ospemifene.
Delafloxacin Delafloxacin The metabolism of Ospemifene can be increased when combined with Delafloxacin.
Letermovir Letermovir The metabolism of Ospemifene can be increased when combined with Letermovir.
Tetrabenazine Tetrabenazine The metabolism of Tetrabenazine can be decreased when combined with Ospemifene.
Buprenorphine Injection Buprenorphine Injection The metabolism of Ospemifene can be decreased when combined with Buprenorphine.
Apalutamide Apalutamide The metabolism of Ospemifene can be increased when combined with Apalutamide.
Avatrombopag Avatrombopag The metabolism of Ospemifene can be increased when combined with Avatrombopag.
Lofexidine Lofexidine The metabolism of Lofexidine can be decreased when combined with Ospemifene.
Eliglustat Eliglustat The metabolism of Eliglustat can be decreased when combined with Ospemifene.
Encorafenib Encorafenib The metabolism of Encorafenib can be decreased when combined with Ospemifene.
Elagolix Elagolix The metabolism of Elagolix can be decreased when combined with Ospemifene.
Tafenoquine Tafenoquine The metabolism of Tafenoquine can be decreased when combined with Ospemifene.
Cannabidiol Cannabidiol The metabolism of Cannabidiol can be decreased when combined with Ospemifene.
Dacomitinib Dacomitinib The metabolism of Dacomitinib can be decreased when combined with Ospemifene.
Stiripentol Stiripentol The metabolism of Ospemifene can be decreased when combined with Stiripentol.
Lorlatinib Lorlatinib The metabolism of Ospemifene can be increased when combined with Lorlatinib.
Rifamycin Rifamycin The metabolism of Ospemifene can be decreased when combined with Rifamycin.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Ospemifene can be increased when combined with Emapalumab.
Siponimod Siponimod The metabolism of Siponimod can be decreased when combined with Ospemifene.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Ospemifene.
Alpelisib Alpelisib The serum concentration of Ospemifene can be decreased when it is combined with Alpelisib.
Triclabendazole Triclabendazole The metabolism of Ospemifene can be decreased when combined with Triclabendazole.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Ospemifene.
Pitolisant Pitolisant The serum concentration of Ospemifene can be decreased when it is combined with Pitolisant.
Phenytoin Injection Phenytoin Injection The metabolism of Ospemifene can be decreased when combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Ospemifene can be decreased when combined with Fosphenytoin.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Ospemifene.
Voxelotor Voxelotor The metabolism of Voxelotor can be decreased when combined with Ospemifene.
Avapritinib Avapritinib The metabolism of Avapritinib can be decreased when combined with Ospemifene.
Cenobamate Cenobamate The serum concentration of Cenobamate can be decreased when it is combined with Ospemifene.
Selumetinib Selumetinib The metabolism of Selumetinib can be decreased when combined with Ospemifene.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Ospemifene.
Lemborexant Lemborexant The serum concentration of Ospemifene can be decreased when it is combined with Lemborexant.
Pralsetinib Pralsetinib The metabolism of Ospemifene can be decreased when combined with Pralsetinib.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Ospemifene can be decreased when it is combined with Satralizumab.
Theophylline Theophylline The metabolism of Theophylline can be decreased when combined with Ospemifene.
Indomethacin Indomethacin The metabolism of Ospemifene can be decreased when combined with Indomethacin.
Mefenamic Acid Mefenamic Acid The metabolism of Ospemifene can be decreased when combined with Mefenamic acid.
Naproxen Naproxen The metabolism of Ospemifene can be decreased when combined with Naproxen.
Trazodone Trazodone The metabolism of Trazodone can be decreased when combined with Ospemifene.
Floxuridine Floxuridine The metabolism of Ospemifene can be decreased when combined with Floxuridine.
Phenobarbital Phenobarbital The metabolism of Ospemifene can be decreased when combined with Phenobarbital.
Primidone Primidone The metabolism of Ospemifene can be decreased when combined with Primidone.
Chlorpromazine Chlorpromazine The metabolism of Chlorpromazine can be decreased when combined with Ospemifene.
Diazepam Diazepam The metabolism of Ospemifene can be decreased when combined with Diazepam.
Codeine Codeine The metabolism of Codeine can be decreased when combined with Ospemifene.
Tranylcypromine Tranylcypromine The metabolism of Ospemifene can be decreased when combined with Tranylcypromine.
Prochlorperazine Prochlorperazine The metabolism of Prochlorperazine can be decreased when combined with Ospemifene.
Thioridazine Thioridazine The metabolism of Thioridazine can be decreased when combined with Ospemifene.
Dapsone Dapsone The metabolism of Ospemifene can be decreased when combined with Dapsone.
Sulfadiazine Sulfadiazine The metabolism of Ospemifene can be decreased when combined with Sulfadiazine.
Oxycodone Oxycodone The metabolism of Oxycodone can be decreased when combined with Ospemifene.
Methadone Methadone The metabolism of Ospemifene can be decreased when combined with Methadone.
Benztropine Benztropine The metabolism of Benzatropine can be decreased when combined with Ospemifene.
Maprotiline Maprotiline The metabolism of Maprotiline can be decreased when combined with Ospemifene.
Ibuprofen Ibuprofen The metabolism of Ospemifene can be decreased when combined with Ibuprofen.
Orphenadrine Orphenadrine The metabolism of Ospemifene can be decreased when combined with Orphenadrine.
Perphenazine Perphenazine The metabolism of Ospemifene can be decreased when combined with Perphenazine.
Amoxapine Amoxapine The metabolism of Amoxapine can be decreased when combined with Ospemifene.
Hydrocortisone Hydrocortisone The metabolism of Ospemifene can be increased when combined with Hydrocortisone.
Doxorubicin Doxorubicin The metabolism of Ospemifene can be decreased when combined with Doxorubicin.
Clonidine Clonidine The metabolism of Clonidine can be decreased when combined with Ospemifene.
Cimetidine Cimetidine The metabolism of Ospemifene can be decreased when combined with Cimetidine.
Warfarin Warfarin The metabolism of Ospemifene can be decreased when combined with Warfarin.
Loperamide Loperamide The metabolism of Ospemifene can be decreased when combined with Loperamide.
Promethazine Promethazine The metabolism of Ospemifene can be decreased when combined with Promethazine.
Chloroquine Chloroquine The metabolism of Chloroquine can be decreased when combined with Ospemifene.
Quinine Quinine The metabolism of Ospemifene can be decreased when combined with Quinine.
Sulfinpyrazone Sulfinpyrazone The metabolism of Ospemifene can be decreased when combined with Sulfinpyrazone.
Desipramine Desipramine The metabolism of Ospemifene can be decreased when combined with Desipramine.
Amitriptyline Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Ospemifene.
Imipramine Imipramine The metabolism of Imipramine can be decreased when combined with Ospemifene.
Probenecid Probenecid The metabolism of Ospemifene can be decreased when combined with Probenecid.
Quinidine Quinidine The metabolism of Ospemifene can be decreased when combined with Quinidine.
Procainamide Procainamide The metabolism of Procainamide can be decreased when combined with Ospemifene.
Isoniazid Isoniazid The metabolism of Ospemifene can be decreased when combined with Isoniazid.
Valproic Acid Valproic Acid The metabolism of Ospemifene can be decreased when combined with Valproic acid.
Tamoxifen Tamoxifen The risk or severity of adverse effects can be increased when Tamoxifen is combined with Ospemifene.
Methimazole Methimazole The metabolism of Ospemifene can be decreased when combined with Methimazole.
Chlorpropamide Chlorpropamide The metabolism of Ospemifene can be decreased when combined with Chlorpropamide.
Tolbutamide Tolbutamide The metabolism of Ospemifene can be decreased when combined with Tolbutamide.
Tolazamide Tolazamide The metabolism of Ospemifene can be decreased when combined with Tolazamide.
Dextromethorphan Dextromethorphan The metabolism of Ospemifene can be decreased when combined with Dextromethorphan.
Chlorpheniramine Chlorpheniramine The metabolism of Chlorpheniramine can be decreased when combined with Ospemifene.
Brompheniramine Brompheniramine The metabolism of Ospemifene can be decreased when combined with Brompheniramine.
Meclizine Meclizine The metabolism of Meclizine can be decreased when combined with Ospemifene.
Chlorzoxazone Chlorzoxazone The metabolism of Chlorzoxazone can be decreased when combined with Ospemifene.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The metabolism of Propranolol can be decreased when combined with Ospemifene.
Nortriptyline Nortriptyline The metabolism of Nortriptyline can be decreased when combined with Ospemifene.
Nadolol Nadolol The metabolism of Nadolol can be decreased when combined with Ospemifene.
Clomiphene Clomiphene The risk or severity of adverse effects can be increased when Clomifene is combined with Ospemifene.
Fluorouracil Injection Fluorouracil Injection The metabolism of Ospemifene can be decreased when combined with Fluorouracil.
Colchicine Colchicine The metabolism of Ospemifene can be decreased when combined with Colchicine.
Ketoconazole Ketoconazole The metabolism of Ospemifene can be decreased when combined with Ketoconazole.
Thiotepa Injection Thiotepa Injection The metabolism of Ospemifene can be decreased when combined with Thiotepa.
Metoprolol Metoprolol The metabolism of Metoprolol can be decreased when combined with Ospemifene.
Aspirin Aspirin The metabolism of Ospemifene can be decreased when combined with Acetylsalicylic acid.
Trimethoprim Trimethoprim The metabolism of Ospemifene can be decreased when combined with Trimethoprim.
Diltiazem Diltiazem The metabolism of Ospemifene can be decreased when combined with Diltiazem.
Nifedipine Nifedipine The metabolism of Ospemifene can be increased when combined with Nifedipine.
Timolol Timolol The metabolism of Timolol can be decreased when combined with Ospemifene.
Verapamil Verapamil The metabolism of Ospemifene can be decreased when combined with Verapamil.
Atenolol Atenolol The metabolism of Atenolol can be decreased when combined with Ospemifene.
Pindolol Pindolol The metabolism of Pindolol can be decreased when combined with Ospemifene.
Cisplatin Injection Cisplatin Injection The metabolism of Ospemifene can be decreased when combined with Cisplatin.
Piroxicam Piroxicam The metabolism of Ospemifene can be decreased when combined with Piroxicam.
Glyburide Glyburide The metabolism of Ospemifene can be decreased when combined with Glyburide.
Glipizide Glipizide The metabolism of Ospemifene can be decreased when combined with Glipizide.
Pentamidine Injection Pentamidine Injection The metabolism of Pentamidine can be decreased when combined with Ospemifene.
Labetalol Labetalol The metabolism of Labetalol can be decreased when combined with Ospemifene.
Gemfibrozil Gemfibrozil The metabolism of Ospemifene can be decreased when combined with Gemfibrozil.
Pimozide Pimozide The metabolism of Pimozide can be decreased when combined with Ospemifene.
Flurbiprofen Flurbiprofen The metabolism of Ospemifene can be decreased when combined with Flurbiprofen.
Amiodarone Amiodarone The metabolism of Ospemifene can be decreased when combined with Amiodarone.
Buspirone Buspirone The metabolism of Buspirone can be decreased when combined with Ospemifene.
Lovastatin Lovastatin The metabolism of Ospemifene can be decreased when combined with Lovastatin.
Diclofenac Diclofenac The metabolism of Ospemifene can be decreased when combined with Diclofenac.
Fluoxetine Fluoxetine The metabolism of Ospemifene can be decreased when combined with Fluoxetine.
Clozapine Clozapine The metabolism of Ospemifene can be decreased when combined with Clozapine.
Idarubicin Idarubicin The metabolism of Ospemifene can be decreased when combined with Idarubicin.
Etodolac Etodolac The metabolism of Ospemifene can be decreased when combined with Etodolac.
Felodipine Felodipine The metabolism of Ospemifene can be decreased when combined with Felodipine.
Nabumetone Nabumetone The metabolism of Ospemifene can be decreased when combined with Nabumetone.
Simvastatin Simvastatin The metabolism of Ospemifene can be decreased when combined with Simvastatin.
Teniposide Injection Teniposide Injection The metabolism of Ospemifene can be decreased when combined with Teniposide.
Itraconazole Itraconazole The metabolism of Ospemifene can be decreased when combined with Itraconazole.
Atovaquone Atovaquone The metabolism of Ospemifene can be decreased when combined with Atovaquone.
Rifabutin Rifabutin The metabolism of Ospemifene can be increased when combined with Rifabutin.
Sotalol Sotalol The metabolism of Sotalol can be decreased when combined with Ospemifene.
Zolpidem Zolpidem The metabolism of Ospemifene can be decreased when combined with Zolpidem.
Doxazosin Doxazosin The metabolism of Ospemifene can be decreased when combined with Doxazosin.
Omeprazole Omeprazole The metabolism of Ospemifene can be decreased when combined with Omeprazole.
Cisapride Cisapride The metabolism of Ospemifene can be decreased when combined with Cisapride.
Fluvastatin Fluvastatin The metabolism of Ospemifene can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine The metabolism of Venlafaxine can be decreased when combined with Ospemifene.
Fluvoxamine Fluvoxamine The metabolism of Ospemifene can be decreased when combined with Fluvoxamine.
Nefazodone Nefazodone The metabolism of Nefazodone can be decreased when combined with Ospemifene.
Losartan Losartan The metabolism of Ospemifene can be decreased when combined with Losartan.
Tramadol Tramadol The metabolism of Ospemifene can be decreased when combined with Tramadol.
Lansoprazole Lansoprazole The metabolism of Ospemifene can be decreased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ospemifene can be decreased when combined with Ifosfamide.
Nicardipine Nicardipine The metabolism of Ospemifene can be decreased when combined with Nicardipine.
Bupropion Bupropion The metabolism of Ospemifene can be decreased when combined with Bupropion.
Ticlopidine Ticlopidine The metabolism of Ospemifene can be decreased when combined with Ticlopidine.
Glimepiride Glimepiride The metabolism of Ospemifene can be decreased when combined with Glimepiride.
Ritonavir Ritonavir The serum concentration of Ospemifene can be increased when it is combined with Ritonavir.
Clomipramine Clomipramine The metabolism of Ospemifene can be decreased when combined with Clomipramine.
Zafirlukast Zafirlukast The metabolism of Ospemifene can be decreased when combined with Zafirlukast.
Mirtazapine Mirtazapine The metabolism of Mirtazapine can be decreased when combined with Ospemifene.
Zileuton Zileuton The metabolism of Ospemifene can be decreased when combined with Zileuton.
Valsartan Valsartan The metabolism of Ospemifene can be decreased when combined with Valsartan.
Donepezil Donepezil The metabolism of Ospemifene can be decreased when combined with Donepezil.
Nelfinavir Nelfinavir The metabolism of Ospemifene can be decreased when combined with Nelfinavir.
Carvedilol Carvedilol The metabolism of Ospemifene can be decreased when combined with Carvedilol.
Nilutamide Nilutamide The metabolism of Ospemifene can be decreased when combined with Nilutamide.
Selegiline Selegiline The metabolism of Ospemifene can be decreased when combined with Selegiline.
Bicalutamide Bicalutamide The metabolism of Ospemifene can be decreased when combined with Bicalutamide.
Sertraline Sertraline The metabolism of Sertraline can be decreased when combined with Ospemifene.
Propafenone Propafenone The metabolism of Propafenone can be decreased when combined with Ospemifene.
Raloxifene Raloxifene The risk or severity of adverse effects can be increased when Raloxifene is combined with Ospemifene.
Irbesartan Irbesartan The metabolism of Ospemifene can be decreased when combined with Irbesartan.
Tamsulosin Tamsulosin The metabolism of Tamsulosin can be decreased when combined with Ospemifene.
Quetiapine Quetiapine The metabolism of Quetiapine can be decreased when combined with Ospemifene.
Paroxetine Paroxetine The metabolism of Ospemifene can be decreased when combined with Paroxetine.
Tolcapone Tolcapone The metabolism of Ospemifene can be decreased when combined with Tolcapone.
Citalopram Citalopram The metabolism of Citalopram can be decreased when combined with Ospemifene.
Capecitabine Capecitabine The metabolism of Ospemifene can be decreased when combined with Capecitabine.
Efavirenz Efavirenz The metabolism of Ospemifene can be decreased when combined with Efavirenz.
Sildenafil Sildenafil The metabolism of Ospemifene can be decreased when combined with Sildenafil.
Celecoxib Celecoxib The metabolism of Ospemifene can be decreased when combined with Celecoxib.
Rosiglitazone Rosiglitazone The metabolism of Ospemifene can be decreased when combined with Rosiglitazone.
Tolterodine Tolterodine The metabolism of Ospemifene can be decreased when combined with Tolterodine.
Thalidomide Thalidomide The metabolism of Ospemifene can be decreased when combined with Thalidomide.
Nateglinide Nateglinide The metabolism of Ospemifene can be decreased when combined with Nateglinide.
Galantamine Galantamine The metabolism of Galantamine can be decreased when combined with Ospemifene.
Rabeprazole Rabeprazole The metabolism of Ospemifene can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Ospemifene can be decreased when combined with Terbinafine.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists