Regorafenib

Generic name: Pronounced as (re'' goe raf' e nib)
Brand names
  • Stivarga®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 05/24/2017

Regorafenib may cause liver damage, which may be severe or life-threatening. Tell your doctor if you have or have ever had liver disease. If you experience any of the following symptoms, call your doctor immediately: yellowing of the skin or eyes, nausea, vomiting, dark colored urine, pain in the upper right part of the stomach, extreme tiredness, unusual bleeding or bruising, lack of energy, loss of appetite, flu-like symptoms, or a change in sleep habits.

Keep all appointments with the laboratory. Your doctor will order certain lab tests before and during your treatment to be sure that it is safe for you to take regorafenib and to check your body's response to the medication.

Regorafenib is used to treat colon and rectal cancer (cancer that begins in the large intestine or the rectum) that has spread to other parts of the body in people who have not been treated successfully with certain other medications. It is also used to treat gastrointestinal stromal tumors (GIST; a type of tumor that grows in the stomach, intestine [bowel], or esophagus [tube that connects the throat with the stomach]) in people who were not treated successfully with certain other medications. Regorafenib is also used to treat hepatocellular carcinoma (HCC; a type of liver cancer) in people who were previously treated with sorafenib (Nexafar). Regorafenib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps to slow or stop the spread of cancer cells.

Regorafenib comes as a tablet to take by mouth. It is usually taken with a low-fat meal (containing under 600 calories and less than 30% of calories from fat) once a day for 3 weeks and then skipped for 1 week. This treatment period is called a cycle, and the cycle may be repeated for as long as your doctor recommends. Take regorafenib at the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take regorafenib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the tablets whole; do not split, chew, or crush them.

Your doctor may decrease your dose of regorafenib or tell you to stop taking regorafenib for a period of time during your treatment. This will depend on how well the medication works for you and any side effects you may experience. Continue to take regorafenib even if you feel well. Do not stop taking regorafenib without talking to your doctor.

Regorafenib is not available at retail pharmacies. Your medication will be mailed to you or to your doctor from a specialty pharmacy. Ask your doctor if you have any questions about how you will receive your medication.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking regorafenib,

  • tell your doctor and pharmacist if you are allergic to regorafenib, any other medications, or any of the ingredients in regorafenib tablets. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements, you are taking or plan to take. Be sure to mention any of the following: anticoagulants (''blood thinners'') such as warfarin (Coumadin, Jantoven); certain antifungal medications such as itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), and voriconazole (Vfend); certain medications for seizures such as carbamazepine (Carbatrol, Epitol, Tegretol), phenobarbital, and phenytoin (Dilantin, Phenytek); atorvastatin (Lipitor, in Caduet); clarithromycin (Biaxin, in Prevpac); fluvastatin (Lescol); irinotecan (Camptosar); methotrexate (Otrexup, Rasuvo, Trexall); rifampin (Rifadin, Rifamate, in Rifater); or telithromycin (Ketek). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor what herbal products you are taking, especially St. John's wort. You should not take St. John's wort while taking regorafenib.

  • tell your doctor if you have a wound that has not healed or if you have or have ever had bleeding problems, high blood pressure, chest pain, or heart, kidney or liver disease. Also tell your doctor if you recently had surgery.

  • tell your doctor if you are pregnant or plan to become pregnant. If you are a female, you should not become pregnant while you are taking regorafenib and for up to 2 months after your final dose. Talk to your doctor about birth control methods that will work for you. If you are male, you and your female partner should use birth control during your treatment and continue to use birth control for 2 months after your final dose. If you or your partner become pregnant while taking regorafenib, call your doctor. Regorafenib may harm the fetus.

  • tell your doctor if you are breast-feeding. You should not breastfeed during your treatment with regorafenib and for up to 2 weeks after your final dose.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking regorafenib. Your doctor probably will tell you to stop taking regorafenib at least 2 weeks before your surgery. Your doctor will tell you when it is safe for you to start taking regorafenib again after your surgery.

Do not eat grapefruit or drink grapefruit juice while taking this medication.

Unless your doctor tells you otherwise, continue your normal diet.

If you miss a dose of regorafenib, take the missed dose as soon as you remember it on that day. Do not take two doses on the same day to make up for a missed one.

  • Regorafenib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • tiredness

    • weakness

    • loss of appetite

    • diarrhea

    • swelling, pain, and redness of the lining of your mouth or throat

    • weight loss

    • hoarseness or other change in the sound of your voice

  • Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately or get emergency medical treatment:

    • chest pain

    • shortness of breath

    • unusual vaginal discharge or irritation

    • burning or pain when urinating

    • dizziness or feeling faint

    • fever, cough, sore throat, chills, and other signs of infection

    • swelling of the abdomen

    • high fever

    • chills

    • severe diarrhea

    • severe headache

    • seizure

    • confusion

    • changes in vision

    • dry mouth, muscle cramps, or decreased urination

    • redness, pain, blisters, bleeding, or swelling on the palms of your hands or soles of your feet

    • rash

    • vomiting blood or vomiting material that looks like coffee grounds

    • pink or brown urine

    • red or black (tarry) stools

    • coughing up blood or blood clots

    • abnormally heavy menstrual bleeding (periods)

    • unusual vaginal bleeding

    • frequent nosebleeds

  • Regorafenib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Do not place the tablets in other containers, such as daily or weekly pill boxes, and do not remove the desiccant (drying agent) from the container. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Dispose of any unused tablets 7 weeks after the bottle is first opened.

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

  • rash or other skin changes

  • voice changes or hoarseness

  • diarrhea

  • swelling inside the nose or mouth

  • dry mouth

  • decreased appetite

  • tiredness

Keep all appointments with your doctor. Your doctor will check your blood pressure before you begin taking regorafenib and regularly during your treatment.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Repaglinide Repaglinide The metabolism of Repaglinide can be decreased when combined with Regorafenib.
Montelukast Montelukast The metabolism of Montelukast can be decreased when combined with Regorafenib.
Leflunomide Leflunomide Regorafenib may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Delavirdine Delavirdine The metabolism of Regorafenib can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Nevirapine can be decreased when combined with Regorafenib.
Atorvastatin Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Regorafenib.
Aminophylline Aminophylline The metabolism of Aminophylline can be decreased when combined with Regorafenib.
Candesartan Candesartan The metabolism of Candesartan can be decreased when combined with Regorafenib.
Cilostazol Cilostazol The metabolism of Cilostazol can be decreased when combined with Regorafenib.
Clopidogrel Clopidogrel The metabolism of Clopidogrel can be decreased when combined with Regorafenib.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The serum concentration of Regorafenib can be increased when it is combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Regorafenib may decrease the excretion rate of Conjugated estrogens which could result in a higher serum level.
Fenofibrate Fenofibrate The metabolism of Fenofibrate can be decreased when combined with Regorafenib.
Guanfacine Guanfacine Guanfacine may increase the bradycardic activities of Regorafenib.
Methylergonovine Methylergonovine The metabolism of Regorafenib can be decreased when combined with Methylergometrine.
Mycophenolate Mycophenolate The metabolism of Mycophenolic acid can be decreased when combined with Regorafenib.
Paregoric Paregoric The metabolism of Morphine can be decreased when combined with Regorafenib.
Penbutolol Penbutolol Regorafenib may increase the bradycardic activities of Acebutolol.
Reserpine Reserpine The serum concentration of Regorafenib can be increased when it is combined with Reserpine.
Sumatriptan Sumatriptan Regorafenib may decrease the excretion rate of Sumatriptan which could result in a higher serum level.
Tacrolimus Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Regorafenib.
Tizanidine Tizanidine Tizanidine may increase the bradycardic activities of Regorafenib.
Triamcinolone Triamcinolone The metabolism of Regorafenib can be increased when combined with Triamcinolone.
Doxycycline Injection Doxycycline Injection The metabolism of Regorafenib can be decreased when combined with Doxycycline.
Fluconazole Injection Fluconazole Injection The serum concentration of Regorafenib can be increased when it is combined with Fluconazole.
Hydromorphone Injection Hydromorphone Injection The metabolism of Hydromorphone can be decreased when combined with Regorafenib.
Meperidine Injection Meperidine Injection The metabolism of Meperidine can be increased when combined with Regorafenib.
Methylprednisolone Injection Methylprednisolone Injection The metabolism of Regorafenib can be increased when combined with Methylprednisolone.
Metronidazole Injection Metronidazole Injection The metabolism of Metronidazole can be decreased when combined with Regorafenib.
Morphine Injection Morphine Injection The metabolism of Morphine can be decreased when combined with Regorafenib.
Zidovudine Injection Zidovudine Injection The metabolism of Zidovudine can be decreased when combined with Regorafenib.
Cyclosporine Cyclosporine The serum concentration of Cyclosporine can be increased when it is combined with Regorafenib.
Ondansetron Ondansetron The metabolism of Ondansetron can be decreased when combined with Regorafenib.
Torsemide Torsemide The metabolism of Torasemide can be decreased when combined with Regorafenib.
Alosetron Alosetron The metabolism of Alosetron can be decreased when combined with Regorafenib.
Dofetilide Dofetilide The metabolism of Dofetilide can be decreased when combined with Regorafenib.
Entacapone Entacapone The metabolism of Entacapone can be decreased when combined with Regorafenib.
Hydroxychloroquine Hydroxychloroquine The metabolism of Hydroxychloroquine can be decreased when combined with Regorafenib.
Meloxicam Meloxicam The metabolism of Meloxicam can be decreased when combined with Regorafenib.
Orlistat Orlistat The metabolism of Regorafenib can be increased when combined with Orlistat.
Oxcarbazepine Oxcarbazepine The metabolism of Regorafenib can be increased when combined with Oxcarbazepine.
Sevelamer Sevelamer Sevelamer can cause a decrease in the absorption of Regorafenib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Anakinra Anakinra The metabolism of Regorafenib can be increased when combined with Anakinra.
Rivastigmine Rivastigmine Rivastigmine may increase the bradycardic activities of Regorafenib.
Trimipramine Trimipramine The serum concentration of Trimipramine can be increased when it is combined with Regorafenib.
Etanercept Injection Etanercept Injection The metabolism of Regorafenib can be increased when combined with Etanercept.
Modafinil Modafinil The metabolism of Regorafenib can be increased when combined with Modafinil.
Tenofovir Tenofovir The metabolism of Tenofovir can be decreased when combined with Regorafenib.
Sirolimus Sirolimus The serum concentration of Sirolimus can be increased when it is combined with Regorafenib.
Epinephrine Injection Epinephrine Injection The metabolism of Regorafenib can be decreased when combined with Epinephrine.
Zonisamide Zonisamide The serum concentration of Zonisamide can be increased when it is combined with Regorafenib.
Adalimumab Injection Adalimumab Injection The metabolism of Regorafenib can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Regorafenib.
Ezetimibe Ezetimibe The metabolism of Ezetimibe can be decreased when combined with Regorafenib.
Teriparatide Injection Teriparatide Injection The therapeutic efficacy of Teriparatide can be decreased when used in combination with Regorafenib.
Atazanavir Atazanavir The metabolism of Atazanavir can be decreased when combined with Regorafenib.
Almotriptan Almotriptan The metabolism of Almotriptan can be decreased when combined with Regorafenib.
Eletriptan Eletriptan The metabolism of Eletriptan can be decreased when combined with Regorafenib.
Mefloquine Mefloquine The metabolism of Regorafenib can be decreased when combined with Mefloquine.
Rosuvastatin Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Regorafenib.
Vardenafil Vardenafil The metabolism of Vardenafil can be decreased when combined with Regorafenib.
Alfuzosin Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Regorafenib.
Aprepitant Aprepitant The metabolism of Regorafenib can be decreased when combined with Aprepitant.
Tegaserod Tegaserod Regorafenib may decrease the excretion rate of Tegaserod which could result in a higher serum level.
Progesterone Progesterone The metabolism of Progesterone can be increased when combined with Regorafenib.
Apomorphine Injection Apomorphine Injection The metabolism of Apomorphine can be decreased when combined with Regorafenib.
Darbepoetin Alfa Injection Darbepoetin Alfa Injection The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Regorafenib.
Infliximab Injection Infliximab Injection The metabolism of Regorafenib can be increased when combined with Infliximab.
Rifaximin Rifaximin The serum concentration of Rifaximin can be increased when it is combined with Regorafenib.
Duloxetine Duloxetine The metabolism of Duloxetine can be decreased when combined with Regorafenib.
Norethindrone Norethindrone The metabolism of Norethisterone can be decreased when combined with Regorafenib.
Bosentan Bosentan The metabolism of Bosentan can be increased when combined with Regorafenib.
Erlotinib Erlotinib The metabolism of Erlotinib can be decreased when combined with Regorafenib.
Eszopiclone Eszopiclone The metabolism of Eszopiclone can be decreased when combined with Regorafenib.
Voriconazole Voriconazole The metabolism of Voriconazole can be decreased when combined with Regorafenib.
Ramelteon Ramelteon The metabolism of Ramelteon can be decreased when combined with Regorafenib.
Fentanyl Fentanyl The metabolism of Fentanyl can be decreased when combined with Regorafenib.
Pregabalin Pregabalin Pregabalin may increase the bradycardic activities of Regorafenib.
Deferasirox Deferasirox The metabolism of Regorafenib can be decreased when combined with Deferasirox.
Tipranavir Tipranavir The serum concentration of Tipranavir can be decreased when it is combined with Regorafenib.
Felbamate Felbamate The metabolism of Regorafenib can be increased when combined with Felbamate.
Ranolazine Ranolazine The serum concentration of Ranolazine can be increased when it is combined with Regorafenib.
Abatacept Injection Abatacept Injection The metabolism of Regorafenib can be increased when combined with Abatacept.
Imatinib Imatinib The metabolism of Regorafenib can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin The serum concentration of Sitagliptin can be increased when it is combined with Regorafenib.
Gefitinib Gefitinib The metabolism of Gefitinib can be decreased when combined with Regorafenib.
Paliperidone Paliperidone The serum concentration of Regorafenib can be increased when it is combined with Paliperidone.
Bortezomib Bortezomib The metabolism of Bortezomib can be decreased when combined with Regorafenib.
Clofarabine Injection Clofarabine Injection Regorafenib may decrease the excretion rate of Clofarabine which could result in a higher serum level.
Fulvestrant Injection Fulvestrant Injection The metabolism of Fulvestrant can be decreased when combined with Regorafenib.
Oxaliplatin Injection Oxaliplatin Injection Regorafenib may decrease the excretion rate of Oxaliplatin which could result in a higher serum level.
Posaconazole Posaconazole The metabolism of Regorafenib can be decreased when combined with Posaconazole.
Primaquine Primaquine The metabolism of Regorafenib can be decreased when combined with Primaquine.
Darunavir Darunavir The serum concentration of Regorafenib can be increased when it is combined with Darunavir.
Retapamulin Retapamulin The metabolism of Retapamulin can be decreased when combined with Regorafenib.
Sorafenib Sorafenib The metabolism of Regorafenib can be decreased when combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Sunitinib can be decreased when combined with Regorafenib.
Dronabinol Dronabinol The metabolism of Dronabinol can be decreased when combined with Regorafenib.
Lapatinib Lapatinib The serum concentration of Lapatinib can be increased when it is combined with Regorafenib.
Dasatinib Dasatinib The metabolism of Dasatinib can be decreased when combined with Regorafenib.
Mexiletine Mexiletine The metabolism of Mexiletine can be decreased when combined with Regorafenib.
Armodafinil Armodafinil The metabolism of Regorafenib can be increased when combined with Armodafinil.
Ivermectin Ivermectin The metabolism of Ivermectin can be increased when combined with Regorafenib.
Temsirolimus Temsirolimus The serum concentration of Temsirolimus can be increased when it is combined with Regorafenib.
Nilotinib Nilotinib The metabolism of Nilotinib can be decreased when combined with Regorafenib.
Toremifene Toremifene The serum concentration of Regorafenib can be increased when it is combined with Toremifene.
Raltegravir Raltegravir The metabolism of Raltegravir can be decreased when combined with Regorafenib.
Bexarotene Bexarotene The metabolism of Bexarotene can be increased when combined with Regorafenib.
Budesonide Budesonide The metabolism of Regorafenib can be increased when combined with Budesonide.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Regorafenib can be decreased when combined with Chloramphenicol.
Etravirine Etravirine The serum concentration of Etravirine can be decreased when it is combined with Regorafenib.
Mitoxantrone Injection Mitoxantrone Injection The metabolism of Mitoxantrone can be decreased when combined with Regorafenib.
Desvenlafaxine Desvenlafaxine The metabolism of Regorafenib can be decreased when combined with Desvenlafaxine.
Nebivolol Nebivolol Regorafenib may increase the bradycardic activities of Nebivolol.
Tretinoin Tretinoin The metabolism of Tretinoin can be decreased when combined with Regorafenib.
Bendamustine Injection Bendamustine Injection The serum concentration of Bendamustine can be increased when it is combined with Regorafenib.
Pilocarpine Pilocarpine The metabolism of Regorafenib can be decreased when combined with Pilocarpine.
Certolizumab Injection Certolizumab Injection The metabolism of Regorafenib can be increased when combined with Certolizumab pegol.
Ixabepilone Injection Ixabepilone Injection The metabolism of Ixabepilone can be decreased when combined with Regorafenib.
Irinotecan Injection Irinotecan Injection The risk or severity of neutropenia can be increased when Regorafenib is combined with Irinotecan.
Mitotane Mitotane The metabolism of Regorafenib can be increased when combined with Mitotane.
Rufinamide Rufinamide The metabolism of Rufinamide can be increased when combined with Regorafenib.
Silodosin Silodosin The serum concentration of Silodosin can be increased when it is combined with Regorafenib.
Midazolam Midazolam The serum concentration of Midazolam can be increased when it is combined with Regorafenib.
Naltrexone Injection Naltrexone Injection The metabolism of Naltrexone can be decreased when combined with Regorafenib.
Eltrombopag Eltrombopag The metabolism of Eltrombopag can be decreased when combined with Regorafenib.
Milnacipran Milnacipran The metabolism of Regorafenib can be decreased when combined with Milnacipran.
Betaxolol Betaxolol Regorafenib may increase the bradycardic activities of Betaxolol.
Iloperidone Iloperidone The metabolism of Iloperidone can be decreased when combined with Regorafenib.
Prasugrel Prasugrel The metabolism of Prasugrel can be decreased when combined with Regorafenib.
Lacosamide Lacosamide The metabolism of Lacosamide can be decreased when combined with Regorafenib.
Everolimus Everolimus The serum concentration of Everolimus can be increased when it is combined with Regorafenib.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The serum concentration of Tolvaptan can be increased when it is combined with Regorafenib.
Dronedarone Dronedarone The serum concentration of Dronedarone can be increased when it is combined with Regorafenib.
Pralatrexate Injection Pralatrexate Injection Regorafenib may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Romidepsin Injection Romidepsin Injection The serum concentration of Romidepsin can be increased when it is combined with Regorafenib.
Tapentadol Tapentadol The metabolism of Tapentadol can be decreased when combined with Regorafenib.
Topotecan Topotecan The serum concentration of Topotecan can be increased when it is combined with Regorafenib.
Golimumab Injection Golimumab Injection The metabolism of Regorafenib can be increased when combined with Golimumab.
Pazopanib Pazopanib The serum concentration of Pazopanib can be increased when it is combined with Regorafenib.
Pitavastatin Pitavastatin Regorafenib may decrease the excretion rate of Pitavastatin which could result in a higher serum level.
Albendazole Albendazole The metabolism of Albendazole can be decreased when combined with Regorafenib.
Tocilizumab Injection Tocilizumab Injection The metabolism of Regorafenib can be increased when combined with Tocilizumab.
Fingolimod Fingolimod Fingolimod may increase the bradycardic activities of Regorafenib.
Cabazitaxel Injection Cabazitaxel Injection The serum concentration of Regorafenib can be increased when it is combined with Cabazitaxel.
Acetaminophen Injection Acetaminophen Injection The metabolism of Acetaminophen can be increased when combined with Regorafenib.
Denileukin Diftitox Injection Denileukin Diftitox Injection The metabolism of Regorafenib can be decreased when combined with Aldesleukin.
Busulfan Injection Busulfan Injection The metabolism of Busulfan can be decreased when combined with Regorafenib.
Roflumilast Roflumilast The metabolism of Roflumilast can be decreased when combined with Regorafenib.
Linagliptin Linagliptin The serum concentration of Regorafenib can be increased when it is combined with Linagliptin.
Rilpivirine Rilpivirine The metabolism of Regorafenib can be decreased when combined with Rilpivirine.
Telaprevir Telaprevir The serum concentration of Glecaprevir can be increased when it is combined with Regorafenib.
Potassium Iodide Potassium Iodide The therapeutic efficacy of Potassium Iodide can be decreased when used in combination with Regorafenib.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Cyclophosphamide can be increased when combined with Regorafenib.
Rivaroxaban Rivaroxaban Regorafenib may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Ticagrelor Ticagrelor The serum concentration of Ticagrelor can be increased when it is combined with Regorafenib.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The serum concentration of Brentuximab vedotin can be increased when it is combined with Regorafenib.
Ruxolitinib Ruxolitinib Ruxolitinib may increase the bradycardic activities of Regorafenib.
Vandetanib Vandetanib The metabolism of Vandetanib can be decreased when combined with Regorafenib.
Clobazam Clobazam The metabolism of Clobazam can be increased when combined with Regorafenib.
Vemurafenib Vemurafenib The metabolism of Vemurafenib can be decreased when combined with Regorafenib.
Vismodegib Vismodegib The metabolism of Vismodegib can be decreased when combined with Regorafenib.
Ivacaftor Ivacaftor The serum concentration of Regorafenib can be increased when it is combined with Ivacaftor.
Axitinib Axitinib The metabolism of Axitinib can be decreased when combined with Regorafenib.
Crizotinib Crizotinib The metabolism of Regorafenib can be decreased when combined with Crizotinib.
Cabergoline Cabergoline The metabolism of Cabergoline can be decreased when combined with Regorafenib.
Naloxone Injection Naloxone Injection The metabolism of Naloxone can be decreased when combined with Regorafenib.
Ambrisentan Ambrisentan The metabolism of Ambrisentan can be decreased when combined with Regorafenib.
Ezogabine Ezogabine The metabolism of Tiagabine can be decreased when combined with Regorafenib.
Carfilzomib Injection Carfilzomib Injection The serum concentration of Carfilzomib can be increased when it is combined with Regorafenib.
Enzalutamide Enzalutamide The serum concentration of Enzalutamide can be increased when it is combined with Regorafenib.
Mirabegron Mirabegron The serum concentration of Regorafenib can be increased when it is combined with Mirabegron.
Bosutinib Bosutinib The serum concentration of Bosutinib can be increased when it is combined with Regorafenib.
Corticotropin, Repository Injection Corticotropin, Repository Injection The metabolism of Regorafenib can be increased when combined with Corticotropin.
Teriflunomide Teriflunomide Regorafenib may decrease the excretion rate of Teriflunomide which could result in a higher serum level.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Regorafenib.
Tofacitinib Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Regorafenib.
Ponatinib Ponatinib The metabolism of Ponatinib can be decreased when combined with Regorafenib.
Pomalidomide Pomalidomide The serum concentration of Pomalidomide can be increased when it is combined with Regorafenib.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The serum concentration of Trastuzumab emtansine can be increased when it is combined with Regorafenib.
Apixaban Apixaban The serum concentration of Apixaban can be increased when it is combined with Regorafenib.
Canagliflozin Canagliflozin The serum concentration of Canagliflozin can be increased when it is combined with Regorafenib.
Dabrafenib Dabrafenib The serum concentration of Dabrafenib can be increased when it is combined with Regorafenib.
Ospemifene Ospemifene The metabolism of Ospemifene can be decreased when combined with Regorafenib.
Trametinib Trametinib The metabolism of Regorafenib can be increased when combined with Trametinib.
Dolutegravir Dolutegravir The metabolism of Dolutegravir can be decreased when combined with Regorafenib.
Afatinib Afatinib The serum concentration of Afatinib can be increased when it is combined with Regorafenib.
Levomilnacipran Levomilnacipran The metabolism of Levomilnacipran can be decreased when combined with Regorafenib.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Regorafenib.
Perampanel Perampanel The metabolism of Perampanel can be increased when combined with Regorafenib.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Regorafenib.
Lomitapide Lomitapide The serum concentration of Lomitapide can be increased when it is combined with Regorafenib.
Ketorolac Injection Ketorolac Injection The metabolism of Ketorolac can be decreased when combined with Regorafenib.
Simeprevir Simeprevir The serum concentration of Simeprevir can be increased when it is combined with Regorafenib.
Sofosbuvir Sofosbuvir The serum concentration of Sofosbuvir can be increased when it is combined with Regorafenib.
Dapagliflozin Dapagliflozin The metabolism of Dapagliflozin can be decreased when combined with Regorafenib.
Apremilast Apremilast The metabolism of Regorafenib can be increased when combined with Apremilast.
Ceritinib Ceritinib Regorafenib may increase the bradycardic activities of Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Regorafenib can be increased when combined with Siltuximab.
Eslicarbazepine Eslicarbazepine The metabolism of Eslicarbazepine can be increased when combined with Regorafenib.
Belinostat Injection Belinostat Injection The metabolism of Belinostat can be decreased when combined with Regorafenib.
Idelalisib Idelalisib The metabolism of Idelalisib can be decreased when combined with Regorafenib.
Testosterone Injection Testosterone Injection The metabolism of Testosterone can be increased when combined with Regorafenib.
Oritavancin Injection Oritavancin Injection The metabolism of Regorafenib can be increased when combined with Oritavancin.
Vorapaxar Vorapaxar The serum concentration of Vorapaxar can be increased when it is combined with Regorafenib.
Hydrocodone Hydrocodone The metabolism of Hydrocodone can be decreased when combined with Regorafenib.
Suvorexant Suvorexant The serum concentration of Suvorexant can be increased when it is combined with Regorafenib.
Edoxaban Edoxaban The serum concentration of Edoxaban can be increased when it is combined with Regorafenib.
Olaparib Olaparib The metabolism of Regorafenib can be decreased when combined with Olaparib.
Tasimelteon Tasimelteon The metabolism of Tasimelteon can be decreased when combined with Regorafenib.
Riociguat Riociguat Regorafenib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Lanreotide Injection Lanreotide Injection The metabolism of Regorafenib can be decreased when combined with Lanreotide.
Nintedanib Nintedanib The metabolism of Nintedanib can be decreased when combined with Regorafenib.
Secukinumab Injection Secukinumab Injection The metabolism of Regorafenib can be increased when combined with Secukinumab.
Palbociclib Palbociclib The metabolism of Palbociclib can be decreased when combined with Regorafenib.
Lenvatinib Lenvatinib The metabolism of Lenvatinib can be increased when combined with Regorafenib.
Naloxegol Naloxegol The serum concentration of Naloxegol can be increased when it is combined with Regorafenib.
Panobinostat Panobinostat The metabolism of Panobinostat can be decreased when combined with Regorafenib.
Haloperidol Injection Haloperidol Injection The serum concentration of Haloperidol can be increased when it is combined with Regorafenib.
Ivabradine Ivabradine Regorafenib may increase the bradycardic activities of Ivabradine.
Isavuconazonium Injection Isavuconazonium Injection The serum concentration of Regorafenib can be increased when it is combined with Isavuconazonium.
Sonidegib Sonidegib The metabolism of Sonidegib can be decreased when combined with Regorafenib.
Flibanserin Flibanserin The serum concentration of Regorafenib can be increased when it is combined with Flibanserin.
Rolapitant Rolapitant The serum concentration of Regorafenib can be increased when it is combined with Rolapitant.
Prednisolone Prednisolone The metabolism of Regorafenib can be increased when combined with Prednisolone.
Daclatasvir Daclatasvir The serum concentration of Regorafenib can be increased when it is combined with Daclatasvir.
Ziprasidone Injection Ziprasidone Injection The metabolism of Ziprasidone can be decreased when combined with Regorafenib.
Cobimetinib Cobimetinib The serum concentration of Cobimetinib can be increased when it is combined with Regorafenib.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Regorafenib.
Osimertinib Osimertinib The serum concentration of Osimertinib can be increased when it is combined with Regorafenib.
Alectinib Alectinib The metabolism of Alectinib can be decreased when combined with Regorafenib.
Ixazomib Ixazomib The metabolism of Ixazomib can be decreased when combined with Regorafenib.
Rifapentine Rifapentine The metabolism of Regorafenib can be increased when combined with Rifapentine.
Lesinurad Lesinurad The metabolism of Lesinurad can be increased when combined with Regorafenib.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The metabolism of Regorafenib can be decreased when combined with Amphotericin B.
Dexamethasone Injection Dexamethasone Injection The metabolism of Regorafenib can be increased when combined with Dexamethasone.
Brivaracetam Injection Brivaracetam Injection The metabolism of Brivaracetam can be decreased when combined with Regorafenib.
Venetoclax Venetoclax The metabolism of Venetoclax can be decreased when combined with Regorafenib.
Cobicistat Cobicistat The serum concentration of Regorafenib can be increased when it is combined with Cobicistat.
Midodrine Midodrine Midodrine may increase the bradycardic activities of Regorafenib.
Selexipag Selexipag The serum concentration of Selexipag can be increased when it is combined with Regorafenib.
Diphenhydramine Injection Diphenhydramine Injection The metabolism of Diphenhydramine can be decreased when combined with Regorafenib.
Furosemide Injection Furosemide Injection The metabolism of Furosemide can be decreased when combined with Regorafenib.
Rucaparib Rucaparib The serum concentration of Rucaparib can be increased when it is combined with Regorafenib.
Ribociclib Ribociclib The metabolism of Ribociclib can be decreased when combined with Regorafenib.
Parathyroid Hormone Injection Parathyroid Hormone Injection The therapeutic efficacy of Parathyroid hormone can be decreased when used in combination with Regorafenib.
Brigatinib Brigatinib The metabolism of Brigatinib can be decreased when combined with Regorafenib.
Doxepin (Insomnia) Doxepin (Insomnia) The metabolism of Doxepin can be decreased when combined with Regorafenib.
Deflazacort Deflazacort The metabolism of Regorafenib can be increased when combined with Deflazacort.
Sarilumab Injection Sarilumab Injection The metabolism of Regorafenib can be increased when combined with Sarilumab.
Midostaurin Midostaurin The metabolism of Midostaurin can be decreased when combined with Regorafenib.
Neratinib Neratinib The metabolism of Neratinib can be decreased when combined with Regorafenib.
Abaloparatide Injection Abaloparatide Injection The therapeutic efficacy of Abaloparatide can be decreased when used in combination with Regorafenib.
Enasidenib Enasidenib The metabolism of Enasidenib can be decreased when combined with Regorafenib.
Inotuzumab Ozogamicin Injection Inotuzumab Ozogamicin Injection The serum concentration of Inotuzumab ozogamicin can be increased when it is combined with Regorafenib.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Fosaprepitant can be increased when combined with Regorafenib.
Copanlisib Injection Copanlisib Injection The serum concentration of Copanlisib can be increased when it is combined with Regorafenib.
Delafloxacin Delafloxacin The metabolism of Delafloxacin can be decreased when combined with Regorafenib.
Abemaciclib Abemaciclib The metabolism of Abemaciclib can be decreased when combined with Regorafenib.
Betrixaban Betrixaban The serum concentration of Betrixaban can be increased when it is combined with Regorafenib.
Acalabrutinib Acalabrutinib The metabolism of Acalabrutinib can be decreased when combined with Regorafenib.
Letermovir Letermovir The metabolism of Letermovir can be decreased when combined with Regorafenib.
Ertugliflozin Ertugliflozin The metabolism of Ertugliflozin can be decreased when combined with Regorafenib.
Buprenorphine Injection Buprenorphine Injection The metabolism of Buprenorphine can be decreased when combined with Regorafenib.
Apalutamide Apalutamide The serum concentration of Apalutamide can be decreased when it is combined with Regorafenib.
Fostamatinib Fostamatinib The metabolism of Fostamatinib can be decreased when combined with Regorafenib.
Avatrombopag Avatrombopag The serum concentration of Avatrombopag can be increased when it is combined with Regorafenib.
Baricitinib Baricitinib The metabolism of Baricitinib can be decreased when combined with Regorafenib.
Eliglustat Eliglustat The metabolism of Eliglustat can be decreased when combined with Regorafenib.
Binimetinib Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Regorafenib.
Ivosidenib Ivosidenib The metabolism of Ivosidenib can be decreased when combined with Regorafenib.
Lusutrombopag Lusutrombopag The serum concentration of Lusutrombopag can be increased when it is combined with Regorafenib.
Elagolix Elagolix The serum concentration of Elagolix can be increased when it is combined with Regorafenib.
Cannabidiol Cannabidiol The metabolism of Cannabidiol can be decreased when combined with Regorafenib.
Dacomitinib Dacomitinib The serum concentration of Dacomitinib can be increased when it is combined with Regorafenib.
Duvelisib Duvelisib The metabolism of Duvelisib can be decreased when combined with Regorafenib.
Omadacycline Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Regorafenib.
Sarecycline Sarecycline The serum concentration of Regorafenib can be increased when it is combined with Sarecycline.
Stiripentol Stiripentol The metabolism of Regorafenib can be decreased when combined with Stiripentol.
Talazoparib Talazoparib The serum concentration of Talazoparib can be increased when it is combined with Regorafenib.
Gilteritinib Gilteritinib The metabolism of Gilteritinib can be decreased when combined with Regorafenib.
Glasdegib Glasdegib The serum concentration of Glasdegib can be increased when it is combined with Regorafenib.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Regorafenib.
Larotrectinib Larotrectinib The serum concentration of Larotrectinib can be increased when it is combined with Regorafenib.
Methoxy Polyethylene Glycol-Epoetin Beta Injection Methoxy Polyethylene Glycol-Epoetin Beta Injection The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Regorafenib.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Regorafenib.
Rifamycin Rifamycin The serum concentration of Rifamycin can be increased when it is combined with Regorafenib.
Prucalopride Prucalopride The serum concentration of Prucalopride can be increased when it is combined with Regorafenib.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Regorafenib can be increased when combined with Emapalumab.
Siponimod Siponimod The metabolism of Siponimod can be decreased when combined with Regorafenib.
Erdafitinib Erdafitinib The serum concentration of Erdafitinib can be increased when it is combined with Regorafenib.
Alpelisib Alpelisib The serum concentration of Alpelisib can be increased when it is combined with Regorafenib.
Cladribine Cladribine Regorafenib may decrease the excretion rate of Cladribine which could result in a higher serum level.
Darolutamide Darolutamide Regorafenib may decrease the excretion rate of Darolutamide which could result in a higher serum level.
Triclabendazole Triclabendazole The metabolism of Triclabendazole can be decreased when combined with Regorafenib.
Entrectinib Entrectinib The metabolism of Entrectinib can be decreased when combined with Regorafenib.
Pexidartinib Pexidartinib Regorafenib may increase the hepatotoxic activities of Pexidartinib.
Istradefylline Istradefylline The serum concentration of Istradefylline can be increased when it is combined with Regorafenib.
Pitolisant Pitolisant The serum concentration of Regorafenib can be decreased when it is combined with Pitolisant.
Fedratinib Fedratinib The serum concentration of Fedratinib can be increased when it is combined with Regorafenib.
Lefamulin Lefamulin Regorafenib may decrease the excretion rate of Lefamulin which could result in a higher serum level.
Phenytoin Injection Phenytoin Injection The metabolism of Phenytoin can be decreased when combined with Regorafenib.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Fosphenytoin can be decreased when combined with Regorafenib.
Enfortumab vedotin-ejfv Injection Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be increased when it is combined with Regorafenib.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Regorafenib.
Voxelotor Voxelotor The serum concentration of Voxelotor can be increased when it is combined with Regorafenib.
Avapritinib Avapritinib The metabolism of Avapritinib can be decreased when combined with Regorafenib.
Lumateperone Lumateperone The serum concentration of Lumateperone can be increased when it is combined with Regorafenib.
Lasmiditan Lasmiditan Regorafenib may increase the bradycardic activities of Lasmiditan.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Regorafenib.
Tazemetostat Tazemetostat The metabolism of Tazemetostat can be decreased when combined with Regorafenib.
Cenobamate Cenobamate The serum concentration of Cenobamate can be decreased when it is combined with Regorafenib.
Ozanimod Ozanimod Regorafenib may decrease the excretion rate of Ozanimod which could result in a higher serum level.
Selumetinib Selumetinib Regorafenib may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Rimegepant Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Regorafenib.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Regorafenib.
Remdesivir Injection Remdesivir Injection The serum concentration of Remdesivir can be increased when it is combined with Regorafenib.
Sacituzumab govitecan-hziy Injection Sacituzumab govitecan-hziy Injection The serum concentration of Sacituzumab govitecan can be increased when it is combined with Regorafenib.
Ripretinib Ripretinib The serum concentration of Ripretinib can be increased when it is combined with Regorafenib.
Capmatinib Capmatinib The serum concentration of Regorafenib can be increased when it is combined with Capmatinib.
Lemborexant Lemborexant The serum concentration of Lemborexant can be increased when it is combined with Regorafenib.
Fostemsavir Fostemsavir Regorafenib may decrease the excretion rate of Fostemsavir which could result in a higher serum level.
Octreotide Octreotide The serum concentration of the active metabolites of Regorafenib can be increased when Regorafenib is used in combination with Octreotide.
Belantamab Mafodotin-blmf Injection Belantamab Mafodotin-blmf Injection The serum concentration of Belantamab mafodotin can be increased when it is combined with Regorafenib.
Pralsetinib Pralsetinib The serum concentration of Pralsetinib can be increased when it is combined with Regorafenib.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Regorafenib can be decreased when it is combined with Satralizumab.
Relugolix Relugolix The serum concentration of Relugolix can be increased when it is combined with Regorafenib.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Drospirenone can be decreased when combined with Regorafenib.
Vitamin E (Alpha-Tocopherol) Vitamin E (Alpha-Tocopherol) The metabolism of Regorafenib can be increased when combined with Vitamin E.
Theophylline Theophylline The metabolism of Theophylline can be decreased when combined with Regorafenib.
Indomethacin Indomethacin The metabolism of Indomethacin can be decreased when combined with Regorafenib.
Mefenamic Acid Mefenamic Acid The metabolism of Regorafenib can be decreased when combined with Mefenamic acid.
Naproxen Naproxen The metabolism of Naproxen can be decreased when combined with Regorafenib.
Trazodone Trazodone The serum concentration of Regorafenib can be decreased when it is combined with Trazodone.
Phenobarbital Phenobarbital The metabolism of Phenobarbital can be increased when combined with Regorafenib.
Methotrexate Injection Methotrexate Injection The metabolism of Methotrexate can be decreased when combined with Regorafenib.
Primidone Primidone The metabolism of Primidone can be increased when combined with Regorafenib.
Methsuximide Methsuximide Methsuximide may increase the bradycardic activities of Regorafenib.
Chlorpromazine Chlorpromazine The metabolism of Chlorpromazine can be increased when combined with Regorafenib.
Diazepam Diazepam The metabolism of Diazepam can be decreased when combined with Regorafenib.
Oxazepam Oxazepam The metabolism of Oxazepam can be decreased when combined with Regorafenib.
Lorazepam Lorazepam The metabolism of Lorazepam can be decreased when combined with Regorafenib.
Bromocriptine Bromocriptine The metabolism of Regorafenib can be decreased when combined with Bromocriptine.
Tranylcypromine Tranylcypromine The metabolism of Regorafenib can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine The metabolism of Regorafenib can be decreased when combined with Phenelzine.
Tetracycline Tetracycline The metabolism of Regorafenib can be decreased when combined with Tetracycline.
Prochlorperazine Prochlorperazine The metabolism of Prochlorperazine can be decreased when combined with Regorafenib.
Dapsone Dapsone The metabolism of Dapsone can be decreased when combined with Regorafenib.
Sulfadiazine Sulfadiazine The metabolism of Sulfadiazine can be decreased when combined with Regorafenib.
Methadone Methadone The metabolism of Methadone can be increased when combined with Regorafenib.
Oxybutynin Oxybutynin The metabolism of Regorafenib can be decreased when combined with Oxybutynin.
Colestipol Colestipol Colestipol can cause a decrease in the absorption of Regorafenib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ibuprofen Ibuprofen The metabolism of Ibuprofen can be decreased when combined with Regorafenib.
Orphenadrine Orphenadrine The metabolism of Regorafenib can be decreased when combined with Orphenadrine.
Phentermine Phentermine The metabolism of Phentermine can be decreased when combined with Regorafenib.
Sulfasalazine Sulfasalazine Regorafenib may decrease the excretion rate of Sulfasalazine which could result in a higher serum level.
Hydrocortisone Hydrocortisone The metabolism of Regorafenib can be increased when combined with Hydrocortisone.
Doxorubicin Doxorubicin The serum concentration of Doxorubicin can be increased when it is combined with Regorafenib.
Dactinomycin Dactinomycin The serum concentration of Regorafenib can be increased when it is combined with Dactinomycin.
Carbamazepine Carbamazepine The metabolism of Carbamazepine can be decreased when combined with Regorafenib.
Methyldopa Methyldopa Methyldopa may increase the bradycardic activities of Regorafenib.
Clonidine Clonidine The metabolism of Regorafenib can be decreased when combined with Clonidine.
Prazosin Prazosin Regorafenib may decrease the excretion rate of Prazosin which could result in a higher serum level.
Hydralazine Hydralazine The metabolism of Regorafenib can be decreased when combined with Hydralazine.
Cimetidine Cimetidine The metabolism of Regorafenib can be decreased when combined with Cimetidine.
Warfarin Warfarin The serum concentration of Warfarin can be increased when it is combined with Regorafenib.
Loperamide Loperamide The metabolism of Regorafenib can be decreased when combined with Loperamide.
Promethazine Promethazine The metabolism of Promethazine can be decreased when combined with Regorafenib.
Daunorubicin Daunorubicin The metabolism of Daunorubicin can be decreased when combined with Regorafenib.
Nitrofurantoin Nitrofurantoin Regorafenib may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Griseofulvin Griseofulvin The metabolism of Regorafenib can be increased when combined with Griseofulvin.
Loxapine Loxapine The serum concentration of Regorafenib can be increased when it is combined with Loxapine.
Chloroquine Chloroquine The metabolism of Chloroquine can be decreased when combined with Regorafenib.
Quinine Quinine The serum concentration of Regorafenib can be increased when it is combined with Quinine.
Ethosuximide Ethosuximide Ethosuximide may increase the bradycardic activities of Regorafenib.
Calcitriol Calcitriol The metabolism of Regorafenib can be increased when combined with Calcitriol.
Sulfinpyrazone Sulfinpyrazone The metabolism of Regorafenib can be increased when combined with Sulfinpyrazone.
Secobarbital Secobarbital The metabolism of Regorafenib can be increased when combined with Secobarbital.
Desipramine Desipramine The metabolism of Desipramine can be decreased when combined with Regorafenib.
Amitriptyline Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Regorafenib.
Imipramine Imipramine The serum concentration of Imipramine can be increased when it is combined with Regorafenib.
Probenecid Probenecid The metabolism of Regorafenib can be increased when combined with Probenecid.
Quinidine Quinidine The serum concentration of Quinidine can be increased when it is combined with Regorafenib.
Isoniazid Isoniazid The metabolism of Regorafenib can be decreased when combined with Isoniazid.
Rifampin Rifampin The metabolism of Regorafenib can be decreased when combined with Rifampicin.
Valproic Acid Valproic Acid The metabolism of Valproic acid can be decreased when combined with Regorafenib.
Tamoxifen Tamoxifen The metabolism of Tamoxifen can be decreased when combined with Regorafenib.
Levothyroxine Levothyroxine The therapeutic efficacy of Levothyroxine can be decreased when used in combination with Regorafenib.
Liothyronine Liothyronine The therapeutic efficacy of Liothyronine can be decreased when used in combination with Regorafenib.
Methimazole Methimazole The therapeutic efficacy of Methimazole can be decreased when used in combination with Regorafenib.
Propylthiouracil Propylthiouracil The therapeutic efficacy of Propylthiouracil can be decreased when used in combination with Regorafenib.
Chlorpropamide Chlorpropamide The metabolism of Chlorpropamide can be decreased when combined with Regorafenib.
Tolbutamide Tolbutamide The metabolism of Tolbutamide can be decreased when combined with Regorafenib.
Tolazamide Tolazamide The metabolism of Tolazamide can be decreased when combined with Regorafenib.
Dextromethorphan Dextromethorphan The metabolism of Dextromethorphan can be decreased when combined with Regorafenib.
Niacin Niacin The metabolism of Regorafenib can be decreased when combined with Niacin.
Brompheniramine Brompheniramine The metabolism of Brompheniramine can be decreased when combined with Regorafenib.
Folic Acid Folic Acid Regorafenib may decrease the excretion rate of Folic acid which could result in a higher serum level.
Danazol Danazol The metabolism of Regorafenib can be decreased when combined with Danazol.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) Regorafenib may increase the bradycardic activities of Propranolol.
Minoxidil Minoxidil The metabolism of Minoxidil can be decreased when combined with Regorafenib.
Nortriptyline Nortriptyline The serum concentration of Nortriptyline can be increased when it is combined with Regorafenib.
Amphotericin B Injection Amphotericin B Injection The metabolism of Regorafenib can be decreased when combined with Amphotericin B.
Nadolol Nadolol Regorafenib may increase the bradycardic activities of Nadolol.
Cholestyramine Resin Cholestyramine Resin Cholestyramine can cause a decrease in the absorption of Regorafenib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Allopurinol Allopurinol Regorafenib may decrease the excretion rate of Allopurinol which could result in a higher serum level.
Clomiphene Clomiphene The serum concentration of Clomifene can be increased when it is combined with Regorafenib.
Fluorouracil Injection Fluorouracil Injection The metabolism of Fluorouracil can be decreased when combined with Regorafenib.
Colchicine Colchicine The metabolism of Colchicine can be decreased when combined with Regorafenib.
Cephalexin Cephalexin The metabolism of Cephalexin can be decreased when combined with Regorafenib.
Acetazolamide Acetazolamide The metabolism of Regorafenib can be decreased when combined with Acetazolamide.
Calcitonin Salmon Injection Calcitonin Salmon Injection The therapeutic efficacy of Salmon calcitonin can be decreased when used in combination with Regorafenib.
Ketoconazole Ketoconazole The serum concentration of Regorafenib can be increased when it is combined with Ketoconazole.
Thiotepa Injection Thiotepa Injection The metabolism of Thiotepa can be decreased when combined with Regorafenib.
Vincristine Injection Vincristine Injection The excretion of Vincristine can be decreased when combined with Regorafenib.
Vinblastine Vinblastine The metabolism of Regorafenib can be decreased when combined with Vinblastine.
Metoprolol Metoprolol Regorafenib may increase the bradycardic activities of Metoprolol.
Aspirin Aspirin The metabolism of Acetylsalicylic acid can be decreased when combined with Regorafenib.
Alprazolam Alprazolam The metabolism of Alprazolam can be decreased when combined with Regorafenib.
Trimethoprim Trimethoprim The metabolism of Trimethoprim can be decreased when combined with Regorafenib.
Diltiazem Diltiazem The metabolism of Diltiazem can be decreased when combined with Regorafenib.
Nifedipine Nifedipine The metabolism of Regorafenib can be increased when combined with Nifedipine.
Timolol Timolol Regorafenib may increase the bradycardic activities of Timolol.
Verapamil Verapamil The serum concentration of Verapamil can be increased when it is combined with Regorafenib.
Atenolol Atenolol Regorafenib may increase the bradycardic activities of Atenolol.
Pindolol Pindolol Regorafenib may increase the bradycardic activities of Pindolol.
Diflunisal Diflunisal The metabolism of Regorafenib can be decreased when combined with Diflunisal.
Piroxicam Piroxicam The metabolism of Piroxicam can be decreased when combined with Regorafenib.
Etoposide Etoposide The serum concentration of Etoposide can be increased when it is combined with Regorafenib.
Glyburide Glyburide The metabolism of Glyburide can be decreased when combined with Regorafenib.
Glipizide Glipizide The metabolism of Glipizide can be decreased when combined with Regorafenib.
Dicloxacillin Dicloxacillin The metabolism of Regorafenib can be increased when combined with Dicloxacillin.
Nafcillin Injection Nafcillin Injection The metabolism of Regorafenib can be increased when combined with Nafcillin.
Labetalol Labetalol Regorafenib may increase the bradycardic activities of Labetalol.
Gemfibrozil Gemfibrozil The metabolism of Gemfibrozil can be decreased when combined with Regorafenib.
Ketoprofen Ketoprofen The metabolism of Ketoprofen can be decreased when combined with Regorafenib.
Pimozide Pimozide The metabolism of Pimozide can be decreased when combined with Regorafenib.
Flurbiprofen Flurbiprofen The metabolism of Flurbiprofen can be decreased when combined with Regorafenib.
Amiodarone Amiodarone The metabolism of Amiodarone can be decreased when combined with Regorafenib.
Lovastatin Lovastatin The metabolism of Lovastatin can be decreased when combined with Regorafenib.
Ciprofloxacin Ciprofloxacin The metabolism of Regorafenib can be decreased when combined with Ciprofloxacin.
Diclofenac Diclofenac The metabolism of Diclofenac can be decreased when combined with Regorafenib.
Fluoxetine Fluoxetine The metabolism of Fluoxetine can be decreased when combined with Regorafenib.
Nimodipine Nimodipine Nimodipine may increase the bradycardic activities of Regorafenib.
Clozapine Clozapine The metabolism of Regorafenib can be increased when combined with Clozapine.
Idarubicin Idarubicin The metabolism of Idarubicin can be decreased when combined with Regorafenib.
Clarithromycin Clarithromycin The serum concentration of Regorafenib can be increased when it is combined with Clarithromycin.
Etodolac Etodolac The metabolism of Etodolac can be decreased when combined with Regorafenib.
Felodipine Felodipine The metabolism of Regorafenib can be decreased when combined with Felodipine.
Nabumetone Nabumetone The metabolism of Nabumetone can be decreased when combined with Regorafenib.
Pravastatin Pravastatin The serum concentration of Pravastatin can be increased when it is combined with Regorafenib.
Simvastatin Simvastatin The serum concentration of Simvastatin can be increased when it is combined with Regorafenib.
Epoetin Alfa, Injection Epoetin Alfa, Injection The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Regorafenib.
Amlodipine Amlodipine Amlodipine may increase the bradycardic activities of Regorafenib.
Teniposide Injection Teniposide Injection The metabolism of Teniposide can be decreased when combined with Regorafenib.
Itraconazole Itraconazole The serum concentration of Regorafenib can be increased when it is combined with Itraconazole.
Rifabutin Rifabutin The metabolism of Regorafenib can be increased when combined with Rifabutin.
Sotalol Sotalol Regorafenib may increase the bradycardic activities of Sotalol.
Bisoprolol Bisoprolol Regorafenib may increase the bradycardic activities of Bisoprolol.
Zolpidem Zolpidem The metabolism of Zolpidem can be decreased when combined with Regorafenib.
Doxazosin Doxazosin The metabolism of Doxazosin can be decreased when combined with Regorafenib.
Isradipine Isradipine The metabolism of Regorafenib can be decreased when combined with Isradipine.
Omeprazole Omeprazole The metabolism of Omeprazole can be increased when combined with Regorafenib.
Cisapride Cisapride The metabolism of Regorafenib can be decreased when combined with Cisapride.
Fluvastatin Fluvastatin The metabolism of Fluvastatin can be decreased when combined with Regorafenib.
Venlafaxine Venlafaxine The metabolism of Venlafaxine can be decreased when combined with Regorafenib.
Famciclovir Famciclovir The metabolism of Famciclovir can be decreased when combined with Regorafenib.
Fluvoxamine Fluvoxamine The metabolism of Regorafenib can be decreased when combined with Fluvoxamine.
Nefazodone Nefazodone The metabolism of Regorafenib can be decreased when combined with Nefazodone.
Lamotrigine Lamotrigine The metabolism of Lamotrigine can be decreased when combined with Regorafenib.
Losartan Losartan The metabolism of Losartan can be decreased when combined with Regorafenib.
Tramadol Tramadol The metabolism of Tramadol can be decreased when combined with Regorafenib.
Vinorelbine Injection Vinorelbine Injection The metabolism of Vinorelbine can be decreased when combined with Regorafenib.
Lansoprazole Lansoprazole The metabolism of Lansoprazole can be increased when combined with Regorafenib.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ifosfamide can be decreased when combined with Regorafenib.
Nicardipine Nicardipine The metabolism of Nicardipine can be decreased when combined with Regorafenib.
Bupropion Bupropion The serum concentration of Bupropion can be increased when it is combined with Regorafenib.
Ticlopidine Ticlopidine The metabolism of Ticlopidine can be decreased when combined with Regorafenib.
Saquinavir Saquinavir The serum concentration of Saquinavir can be increased when it is combined with Regorafenib.
Nisoldipine Nisoldipine Nisoldipine may increase the bradycardic activities of Regorafenib.
Lamivudine Lamivudine Regorafenib may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Riluzole Riluzole Regorafenib may decrease the excretion rate of Riluzole which could result in a higher serum level.
Glimepiride Glimepiride The metabolism of Glimepiride can be decreased when combined with Regorafenib.
Anastrozole Anastrozole The metabolism of Anastrozole can be decreased when combined with Regorafenib.
Gemcitabine Injection Gemcitabine Injection The serum concentration of Gemcitabine can be increased when it is combined with Regorafenib.
Ritonavir Ritonavir The serum concentration of Ritonavir can be increased when it is combined with Regorafenib.
Docetaxel Injection Docetaxel Injection The metabolism of Docetaxel can be decreased when combined with Regorafenib.
Clomipramine Clomipramine The metabolism of Clomipramine can be decreased when combined with Regorafenib.
Zafirlukast Zafirlukast The metabolism of Zafirlukast can be decreased when combined with Regorafenib.
Mirtazapine Mirtazapine The metabolism of Regorafenib can be decreased when combined with Mirtazapine.
Topiramate Topiramate The metabolism of Regorafenib can be increased when combined with Topiramate.
Zileuton Zileuton The metabolism of Zileuton can be decreased when combined with Regorafenib.
Valsartan Valsartan The metabolism of Valsartan can be decreased when combined with Regorafenib.
Donepezil Donepezil Regorafenib may decrease the excretion rate of Donepezil which could result in a higher serum level.
Fexofenadine Fexofenadine The serum concentration of Regorafenib can be increased when it is combined with Fexofenadine.
Azithromycin Azithromycin The metabolism of Azithromycin can be decreased when combined with Regorafenib.
Carvedilol Carvedilol Regorafenib may increase the bradycardic activities of Carvedilol.
Selegiline Selegiline The metabolism of Selegiline can be decreased when combined with Regorafenib.
Bicalutamide Bicalutamide The metabolism of Regorafenib can be decreased when combined with Bicalutamide.
Sertraline Sertraline The metabolism of Sertraline can be decreased when combined with Regorafenib.
Propafenone Propafenone Regorafenib may increase the bradycardic activities of Propafenone.
Raloxifene Raloxifene The metabolism of Raloxifene can be decreased when combined with Regorafenib.
Irbesartan Irbesartan The metabolism of Irbesartan can be decreased when combined with Regorafenib.
Paroxetine Paroxetine The metabolism of Regorafenib can be decreased when combined with Paroxetine.
Citalopram Citalopram The metabolism of Regorafenib can be decreased when combined with Citalopram.
Capecitabine Capecitabine The metabolism of Capecitabine can be decreased when combined with Regorafenib.
Efavirenz Efavirenz The metabolism of Efavirenz can be increased when combined with Regorafenib.
Abacavir Abacavir The metabolism of Abacavir can be decreased when combined with Regorafenib.
Sildenafil Sildenafil The serum concentration of Regorafenib can be increased when it is combined with Sildenafil.
Pioglitazone Pioglitazone The metabolism of Pioglitazone can be decreased when combined with Regorafenib.
Celecoxib Celecoxib Regorafenib may decrease the excretion rate of Celecoxib which could result in a higher serum level.
Rosiglitazone Rosiglitazone The metabolism of Rosiglitazone can be decreased when combined with Regorafenib.
Tolterodine Tolterodine The metabolism of Tolterodine can be decreased when combined with Regorafenib.
Thalidomide Thalidomide The metabolism of Thalidomide can be decreased when combined with Regorafenib.
Colesevelam Colesevelam Colesevelam can cause a decrease in the absorption of Regorafenib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Nateglinide Nateglinide The metabolism of Nateglinide can be decreased when combined with Regorafenib.
Galantamine Galantamine Galantamine may increase the bradycardic activities of Regorafenib.
Rabeprazole Rabeprazole The metabolism of Regorafenib can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Terbinafine can be increased when combined with Regorafenib.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists