FDA-filed SPL labeling · retrieved through openFDA

Flurandrenolide Topical

Flurandrenolide is a topical corticosteroid used to relieve inflammation and itching caused by a range of corticosteroid-responsive skin conditions.

Brand names CordranCordran SP
Drug class Corticosteroid
Rx Form 1 Route Topical
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 5 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

At a glance
Linked label effectiveJul 7, 2025
Clinical labels in scope 5
AvailabilityRx
Earliest approval/marketing year 1963
FDA-listed product records 16
Boxed warningNone found in compared labels
How we combine label and product data →
No current FDA shortage listed · checked Sep 23, 2026
Flurandrenolide Topical at a glance The quick version — the full detail is in the Patient Information Guide below.
💊
HelloPharmacist Editorial Team Bottom Line
Flurandrenolide is a topical corticosteroid that effectively calms inflammation and itching in a variety of skin conditions. Use it exactly as directed — overuse or covering treated skin tightly can increase absorption and raise the risk of side effects. If your skin worsens, shows signs of infection, or you notice unusual changes, check in with your prescriber.

📖 Flurandrenolide Topical: Patient Information Guide

A plain-language walkthrough of Flurandrenolide Topical — what it treats, how it works, how it’s taken, side effects, warnings and interactions. Tap any section to expand it.

🎯What it's used for

Flurandrenolide topical is used to relieve inflammation and itching in skin conditions that respond to corticosteroid treatment.

  • Cordran is indicated for the relief of inflammatory and itchy manifestations of corticosteroid-responsive dermatoses (skin conditions that improve with steroid therapy, such as eczema, psoriasis, and allergic skin reactions)
  • Cordran used with occlusive dressings may be helpful for psoriasis or resistant skin conditions that don't respond easily to standard treatment
⚙️How it works

Cordran works through three main actions: reducing inflammation, relieving itch, and constricting (narrowing) blood vessels in the skin. It is thought to stabilize the membranes of cells and lysosomes (tiny cellular compartments that release inflammatory enzymes), preventing those enzymes from breaking down tissue and fueling inflammation. The result is calmer, less irritated skin.

When Cordran Tape is used, the tape itself acts as an occlusive (airtight) covering. This traps moisture in the outer skin layer, helping more medication absorb into the skin and protecting the area from scratching, rubbing, and irritants — which boosts the tape's effectiveness.

💊How it's taken

Flurandrenolide is applied directly to the affected skin area — it is not taken by mouth. Follow your prescriber's instructions carefully for how often to apply and how much area to cover. For Cordran Tape, the standard recommendation is to replace the tape every 12 hours, since this produces the fewest side effects. The tape may be left on for up to 24 hours if it is comfortable and sticks well, or used at night only if preferred.

  • If the edges of Cordran Tape loosen early, trim them and replace with fresh tape
  • Do not use occlusive dressings if a skin infection is present
  • Always follow the specific directions your doctor or pharmacist provides
🤒Side effects — in detail

Most side effects from flurandrenolide happen at the skin where it is applied and are generally infrequent — but they occur more often when occlusive dressings are used.

  • Burning or stinging
  • Itching
  • Skin irritation
  • Dryness
  • Folliculitis (inflamed hair follicles)
  • Hypertrichosis (increased hair growth in the treated area)
  • Acne-like breakouts
  • Skin lightening (hypopigmentation)
  • Perioral dermatitis (rash around the mouth)
  • Allergic contact dermatitis (skin allergic reaction)

With occlusive dressings, more serious skin changes can happen: skin thinning (atrophy), stretch marks (striae), secondary infections, skin maceration (over-softening), and miliaria (heat rash). Tell your doctor if you notice any of these.

⚠️Warnings & precautions
  • Systemic absorption: Flurandrenolide can be absorbed through the skin into your bloodstream — especially on large areas, inflamed skin, or under airtight dressings. Absorbed amounts can cause body-wide steroid effects.
  • Occlusive dressings increase risk: Using Cordran Tape or other airtight coverings raises the chance of skin thinning, stretch marks, infections, and maceration.
  • Infections: If a skin infection develops, stop occlusive dressings immediately and contact your prescriber for appropriate treatment.
  • Cordran Tape restrictions: Cordran Tape should not be used on oozing lesions or in skin folds (intertriginous areas).
🔀What it interacts with

The FDA label for flurandrenolide topical does not list specific drug, food, or supplement interactions.

    This is not a complete list of interactions. Always talk with your doctor or pharmacist before starting, stopping, or changing any medication.

    📋Before taking it
    • Tell your doctor if you have ever been allergic to any topical corticosteroid or to any ingredient in these products
    • Cordran Tape should not be used on skin that is oozing or weeping fluid
    • Cordran Tape is not recommended for skin folds (intertriginous areas such as underarms or groin)
    • Inform your prescriber if you have any active skin infection in the area to be treated
    • Use cautiously over large skin areas or under occlusive coverings, since more medication can be absorbed and cause body-wide effects
    🚑If you take too much

    Topical flurandrenolide can be absorbed through the skin in amounts large enough to cause systemic (body-wide) effects if overused — particularly with occlusive dressings or on large skin areas. If you think you or someone else has absorbed too much, contact a healthcare provider or poison control center right away.

    📡Pharmacodynamics — effects in the body

    Flurandrenolide reduces inflammation, relieves itching, and causes blood vessels in the skin to narrow (vasoconstriction). These effects work together to calm redness, swelling, and discomfort in irritated skin. Laboratory studies suggest that the degree of vasoconstriction correlates with how effective a topical corticosteroid will be in practice.

    🔬Pharmacokinetics — how your body processes it

    How much flurandrenolide is absorbed through the skin depends on the product vehicle (the base it's mixed into), the condition of the skin barrier, and whether an occlusive dressing is used. Inflamed or damaged skin absorbs more medication than healthy skin, and occlusive dressings substantially increase absorption. Once absorbed, it is processed like other corticosteroids — broken down primarily in the liver and eliminated mainly through the kidneys, with some leaving through bile.

    📦How to store it

    Keep tightly closed. Protect from light. Store at 20° to 25°C (68° to 77°F) with excursions permitted to 15° to 30°C (59° to 86°F) .

    📄 Written from Flurandrenolide Topical’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Every point is grounded in that labeling — nothing is invented. How we use AI →

    3

    Supplements & herbs that interact with Flurandrenolide Topical

    3 supplements and herbal products have documented interactions with Flurandrenolide Topical in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

    Severity mix
    • Moderate · 2
    • Minor · 1
    Every supplement checked against Flurandrenolide Topical — ranked by severity The full interaction hub: 2 moderate · 1 minor · every one linked to its full report. Check Flurandrenolide Topical against your exact supplements

    Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

    🩺 Pharmacist Counseling Corner

    Quick, plain-English answers to the questions patients ask most about Flurandrenolide Topical — the kind of thing our pharmacy team would talk through with you at the counter.

    What skin conditions is flurandrenolide used for?
    It's used for skin conditions that respond to steroid treatment — things like eczema, psoriasis, and allergic skin reactions that cause inflammation and itching. Your doctor may also use it for other corticosteroid-responsive conditions. Cordran in tape form can be especially useful for stubborn, hard-to-treat patches of skin.
    How often do I need to change the Cordran Tape?
    The general guideline is to replace Cordran Tape every 12 hours — this is when side effects are least likely to occur. If the tape is comfortable and sticking well, your doctor may say it's okay to leave it on for up to 24 hours. You can also use it only at night and take it off during the day if that works better for you. If the edges start peeling, just trim them and put fresh tape over the spot.
    What side effects should I watch out for?
    The most common ones are mild and happen right where you apply it — burning, itching, irritation, or dryness. If you use Cordran Tape or another airtight covering, keep an eye out for skin thinning, stretch marks, or signs of a skin infection like redness spreading, warmth, or pus. Those are worth a call to your doctor. Lighter skin color in the treated area can also happen over time.
    Can this medication get into my bloodstream?
    Yes, it can — that's an important thing to know. Topical corticosteroids like flurandrenolide are absorbed through the skin, especially if you apply it to a large area, use it under an airtight dressing, or if the skin is inflamed or broken. Using it exactly as directed and not covering it up unnecessarily keeps that absorption to a minimum.
    Are there situations where I shouldn't use Cordran Tape?
    Yes. Don't use Cordran Tape if the skin is oozing or weeping fluid, and avoid using it in skin folds like your underarms or groin. Also, if a skin infection develops under the tape, stop the tape and let your doctor know — you'll need treatment for the infection first before continuing.
    What if I'm allergic to a topical steroid — can I still use this?
    If you've had an allergic reaction to a topical corticosteroid or any ingredient in these preparations before, flurandrenolide is contraindicated — meaning you should not use it. Make sure to tell your doctor and pharmacist about any past reactions. Allergic contact dermatitis (a skin allergy) is a known, though infrequent, reaction to topical steroids.
    Is Flurandrenolide Topical available over the counter?
    Flurandrenolide Topical is dispensed by prescription according to its FDA labeling, so it isn't sold over the counter. Your prescriber and pharmacist will determine if it's appropriate for you.
    When was Flurandrenolide Topical first available?
    Flurandrenolide Topical has been available in the United States since at least 1963, based on FDA approval history (Drugs@FDA) and product marketing records.
    Who makes Flurandrenolide Topical?
    Flurandrenolide Topical is supplied by 6 manufacturers listed in the FDA NDC Directory, including Almirall, LLC, Bryant Ranch Prepack, INA Pharmaceutics, Inc.

    💬 Answers drafted from Flurandrenolide Topical’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Grounded in that labeling — nothing is made up. How we use AI →

    🧰 Keep exploring

    💊 How Flurandrenolide Topical comes

    Flurandrenolide Topical is available in 1 form. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

    Topical cream, ointment or gel

    On the skin
    Brands Cordran
    How this form is used
    What it may be used for
    • Cordran is used to relieve inflammation and itching caused by corticosteroid-responsive skin conditions
    • Cordran may be used with occlusive dressings for psoriasis or hard-to-treat skin conditions
    Important instructions
    • Cordran is applied directly to the affected skin; follow your prescriber's directions for how often to apply
    • Cordran Tape is typically replaced every 12 hours, or may be left for up to 24 hours if well tolerated and adhering properly
    • Cordran Tape may be worn at night only and removed during the day if needed
    • If a skin infection develops, stop using Cordran Tape or any occlusive dressing and contact your doctor
    Available strengths 5 strengths
    16 FDA-listed product records

    📊 Flurandrenolide Topical across the U.S. market

    How Flurandrenolide Topical appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

    1
    Dose forms
    6
    Manufacturers
    2
    Brand names
    16
    FDA-listed product records
    1963
    First marketed
    Almirall, LLC50%
    Bryant Ranch Prepack19%
    INA Pharmaceutics, Inc13%
    Padagis Israel Pharmaceuticals Ltd6%
    Taro Pharmaceuticals U.S.A., Inc.6%
    Teligent Pharma, Inc.6%

    Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

    📈 How widely Flurandrenolide Topical is used

    A general measure of how commonly Flurandrenolide Topical is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

    Think of this as a proxy for how widely Flurandrenolide Topical is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

    615
    Medicaid prescriptions filled (Q1–Q4 2025)
    $152,586 gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

    How commonly is Flurandrenolide Topical prescribed? Of the 1,596 medications we measure, Flurandrenolide Topical ranks #1,342 by Medicaid prescriptions — more than 16% of them.

    Where Flurandrenolide Topical ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5

    Utilization by Flurandrenolide Topical product

    Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

    flurandrenolide 0.5 MG/ML Topical Lotion

    615 Medicaid prescriptions (Q1–Q4 2025) 100% of Flurandrenolide Topical prescriptions shown $152,586 gross reimbursement (before rebates) ≈ $248 per prescription (gross)

    Summed across the 1 of 5 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 197719

    Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

    Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Flurandrenolide Topical, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 1 of 5 listed Flurandrenolide Topical NDCs with Medicaid activity.

    🔍 Compare Flurandrenolide Topical products

    A representative set of FDA-listed product records for Flurandrenolide Topical — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

    Strength Route Manufacturer / Labeler Category Details
    💊Topical cream, ointment or gel
    4 mcg/cm2 Topical Almirall, LLC × 2 listings NDA View NDC →
    FLURANDRENOLIDE 4 mcg/cm2 Topical Almirall, LLC NDA View NDC →
    0.25 mg/g Topical Almirall, LLC NDA Find on DailyMed
    0.5 mg/g Topical Almirall, LLC × 3 listings NDA View NDC →
    0.5 mg/mL Topical Almirall, LLC NDA View NDC →
    0.5 mg/mL Topical Bryant Ranch Prepack × 3 listings ANDA View NDC →
    0.5 mg/g Topical INA Pharmaceutics, Inc × 2 listings NDA View NDC →
    0.5 mg/mL Topical Padagis Israel Pharmaceuticals Ltd ANDA View NDC →
    0.5 mg/g Topical Taro Pharmaceuticals U.S.A., Inc. NDA View NDC →
    0.5 mg/g Topical Teligent Pharma, Inc. ANDA Find on DailyMed

    Showing 16 of 16 products — FDA National Drug Code Directory. See every product, package size and price: browse all 16 Flurandrenolide Topical NDCs →

    RxNorm Concept Web — From Ingredient to Every Form and Strength

    This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

    Ingredient (IN) Flurandrenolide Topical RxCUI 4500 4 dose forms · 8 strengths
    1. Dose form (SCDF) Medicated Tape RxCUI 797693 In current FDA listings
      Clinical drug / strength (SCD) 0.004 MG/SQCM RxCUI 797694
    2. Dose form (SCDF) Topical Cream RxCUI 378619 In current FDA listings
      Clinical drug / strength (SCD) 0.125 MG/ML RxCUI 245636 0.25 MG/ML RxCUI 197716 0.5 MG/ML RxCUI 197718
    3. Dose form (SCDF) Topical Lotion RxCUI 378234 In current FDA listings
      Clinical drug / strength (SCD) 0.5 MG/ML RxCUI 197719
    4. Dose form (SCDF) Topical Ointment RxCUI 372242 In current FDA listings
      Clinical drug / strength (SCD) 0.000125 MG/MG RxCUI 245637 0.00025 MG/MG RxCUI 197717 0.0005 MG/MG RxCUI 197720

    Look up RxCUI 4500 in the RxCUI Atlas →

    RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

    🏷️ Sold under these brand names

    Cordran Cordran SP

    🏭 Manufacturers & labelers

    Almirall, LLC 8 Bryant Ranch Prepack 3 INA Pharmaceutics, Inc 2 Padagis Israel Pharmaceuticals Ltd 1 Taro Pharmaceuticals U.S.A., Inc. 1 Teligent Pharma, Inc. 1

    RxNorm drug class

    Flurandrenolide Topical belongs to the Corticosteroid class.

    Pharmacologic class Corticosteroid
    Drug family (ATC) Corticosteroids, potent (group III)
    How it works Corticosteroid Hormone Receptor Agonists

    Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

    🔬 Where this comes from

    Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

    📄
    FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Jul 7, 2025
    🏭
    Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Flurandrenolide Topical.
    📈
    Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
    🚨
    Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
    🧾 Clinical label set — FDA-filed SPL labels retained for Flurandrenolide Topical after exact ingredient or ingredient-combination matching and applicable route/form matching
    Clinical labels in scope
    5
    NDC products indexed
    16
    Distinct labelers/manufacturers represented
    6
    Linked representative label
    INA Pharmaceutics, Inc
    Linked label effective
    Jul 7, 2025
    Composite sections available
    14
    Linked SPL Set ID
    39c0d1e6-6816-7ae5-e063-6394a90a592e
    Linked SPL Document ID
    39d4fc80-5bee-3f1d-e063-6294a90a3d69
    Open the linked representative label on DailyMed ↗

    How we combine label and product data

    HelloPharmacist combines public FDA and NLM records; we don’t author the underlying clinical facts. We identified 5 FDA-filed SPL label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. The representative label is the starting point for the displayed reference monograph; the 12 largest stored in-scope SPL records, which may include that representative, are compared section by section, and the longest available version of each section is retained. Forms, routes, brands, labelers, product-listed strengths, and product-record counts are aggregated separately from ingredient-matched FDA NDC Directory records; package records listed above are associated with the linked SPL; and the normalized concept hierarchy comes from NLM RxNorm.

    Where a section is identified as AI-written, its plain-language text is generated from bounded label evidence. New draft drug pages remain in the admin review queue before first publication. INA Pharmaceutics, Inc is the representative DailyMed label linked for verification and dates; it is not the sole source used for the page.

    This is general education, not medical advice — always consult your doctor or pharmacist about your medications and any medical condition. For the exact wording of the linked representative label, view that label on DailyMed; some displayed composite sections may come from other in-scope SPL labels. Learn how we use AI and our data sources & update cadence.