Trametinib

Generic name: Pronounced as (tra me' ti nib)
Brand names
  • Mekinist®
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Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 06/15/2018

Trametinib is used alone or in combination with dabrafenib (Tafinlar) to treat a certain types of melanoma (a type of skin cancer) that cannot be treated with surgery or that has spread to other parts of the body. It is used in combination with dabrafenib to treat and prevent the return of a certain type of melanoma after surgery to remove it and any affected lymph nodes. Trametinib is also used in combination with dabrafenib to treat a certain type of non-small-cell lung cancer (NSCLC) that has spread to nearby tissues or to other parts of the body. It is used in combination with dabrafenib to treat a certain type of thyroid cancer that has spread to nearby tissues or to other parts of the body, which cannot be treated with other therapies. Trametinib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps stop the spread of cancer cells.

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Trametinib comes as a tablet to take by mouth. It is usually taken once a day on an empty stomach, at least 1 hour before or 2 hours after a meal. Take trametinib at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take trametinib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Do not stop taking trametinib without talking to your doctor.

Your doctor may adjust your dose of trametinib depending on your response to treatment and any side effects that you experience. Talk to your doctor about how you are feeling during your treatment.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking trametinib,

  • tell your doctor and pharmacist if you are allergic to trametinib, any other medications, or any of the ingredients in trametinib tablets. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.

  • tell your doctor if you have or have ever had lung disease or breathing problems; diabetes; bleeding problems or blood clots; colitis (inflammation of the colon); stomach problems; high blood pressure; heart, eye, liver, or kidney disease; or any other medical conditions.

  • tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while you are taking trametinib. You should use birth control to prevent pregnancy during your treatment with trametinib and for 4 months after your final dose. Talk to your doctor about birth control methods that will work for you. If you become pregnant while taking trametinib, call your doctor. Trametinib may harm the fetus.

  • tell your doctor if you are breastfeeding or plan to breastfeed. You should not breastfeed while taking trametinib and for 4 months after your final dose.

  • you should know that this medication may decrease fertility in women. Talk to your doctor about the risks of taking trametinib.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose as soon as you remember it. However, if it is less than 12 hours until your next scheduled dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Trametinib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • dry skin

    • sores on the mouth and tongue

    • dry mouth

    • vomiting

    • loss of appetite

    • change in ability to taste food

    • tiredness

  • Some side effects can be serious. If you experience any of these symptoms, stop taking trametinib and call your doctor immediately:

    • unusual bleeding or bruising

    • bloody or black, tarry stools

    • coughing up or vomiting blood or material that looks like coffee grounds

    • nosebleed

    • severe diarrhea

    • stomach pain

    • nausea

    • fever

    • chills

    • rapid, irregular, or pounding heartbeat

    • difficulty breathing

    • chest pain

    • swelling of the face, arms, legs, ankles, or feet

    • dizziness, lightheadedness, or weakness

    • shortness of breath

    • leg pain, swelling, tenderness, redness, or warmth

    • severe headache

    • cough

    • blurred vision

    • change in vision, including seeing halos (blurred outline around objects) or colored dots

    • loss of vision

    • eye pain

    • dry, red, or swollen eyes

    • rash, red skin, or pimples

    • wart

    • a reddish bump that bleeds or does not heal

    • change in size or color of a mole

    • itching

    • blisters, ulcers, or sores on the skin or nails

    • tingling, burning, redness, swelling, peeling or flaking, blisters, or sores on the palms of the hands or soles of the feet

    • frequent urination

    • increased thirst

  • Trametinib may increase the risk that you will develop new skin cancers or other cancers. Talk to your doctor about the risks of taking this medication.

  • Trametinib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, away from moisture and light, and out of the reach of children. Do not place the tablets in other containers, such as daily or weekly pill boxes. Store it in a refrigerator, but do not freeze it. Do not remove the desiccant (small packet included with medication to absorb moisture) from your bottle.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

  • vision problems

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests before and during your treatment to see if it is safe for you to receive trametinib and to check your body's response to trametinib. Your doctor will also check your skin for any changes before you begin treatment, every 2 months during your treatment, and for up to 6 months after treatment. Your doctor will also check your blood pressure from time to time as needed.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Repaglinide Repaglinide The metabolism of Repaglinide can be decreased when combined with Trametinib.
Montelukast Montelukast The metabolism of Montelukast can be decreased when combined with Trametinib.
Atorvastatin Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Trametinib.
Aminophylline Aminophylline The metabolism of Aminophylline can be increased when combined with Trametinib.
Cilostazol Cilostazol Cilostazol may decrease the excretion rate of Trametinib which could result in a higher serum level.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Conjugated estrogens may decrease the excretion rate of Trametinib which could result in a higher serum level.
Fenofibrate Fenofibrate The metabolism of Trametinib can be increased when combined with Fenofibrate.
Guanfacine Guanfacine Guanfacine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Magnesium Hydroxide Magnesium Hydroxide Trametinib may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Mycophenolate Mycophenolate Mycophenolic acid may decrease the excretion rate of Trametinib which could result in a higher serum level.
Olsalazine Olsalazine Olsalazine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Paregoric Paregoric The metabolism of Morphine can be decreased when combined with Trametinib.
Potassium Potassium Potassium cation may increase the excretion rate of Trametinib which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone Prednisone Prednisone may decrease the excretion rate of Trametinib which could result in a higher serum level.
Ranitidine Ranitidine Ranitidine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Reserpine Reserpine Reserpine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Rizatriptan Rizatriptan Rizatriptan may decrease the excretion rate of Trametinib which could result in a higher serum level.
Sumatriptan Sumatriptan Sumatriptan may decrease the excretion rate of Trametinib which could result in a higher serum level.
Tacrolimus Tacrolimus The metabolism of Tacrolimus can be increased when combined with Trametinib.
Ampicillin Injection Ampicillin Injection Ampicillin may decrease the excretion rate of Trametinib which could result in a higher serum level.
Doxycycline Injection Doxycycline Injection Doxycycline may decrease the excretion rate of Trametinib which could result in a higher serum level.
Fluconazole Injection Fluconazole Injection Fluconazole may decrease the excretion rate of Trametinib which could result in a higher serum level.
Foscarnet Injection Foscarnet Injection Foscarnet may decrease the excretion rate of Trametinib which could result in a higher serum level.
Hydromorphone Injection Hydromorphone Injection Hydromorphone may decrease the excretion rate of Trametinib which could result in a higher serum level.
Levofloxacin Injection Levofloxacin Injection Levofloxacin may decrease the excretion rate of Trametinib which could result in a higher serum level.
Meperidine Injection Meperidine Injection The metabolism of Trametinib can be increased when combined with Meperidine.
Metoclopramide Injection Metoclopramide Injection Metoclopramide may decrease the excretion rate of Trametinib which could result in a higher serum level.
Morphine Injection Morphine Injection The metabolism of Morphine can be decreased when combined with Trametinib.
Pamidronate Injection Pamidronate Injection Pamidronic acid may decrease the excretion rate of Trametinib which could result in a higher serum level.
Vancomycin Injection Vancomycin Injection Trametinib may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Zidovudine Injection Zidovudine Injection The metabolism of Zidovudine can be decreased when combined with Trametinib.
Altretamine Altretamine Amphetamine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Cefuroxime Cefuroxime Cefuroxime may decrease the excretion rate of Trametinib which could result in a higher serum level.
Cyclosporine Cyclosporine The metabolism of Cyclosporine can be increased when combined with Trametinib.
Torsemide Torsemide The metabolism of Torasemide can be decreased when combined with Trametinib.
Dofetilide Dofetilide The metabolism of Dofetilide can be increased when combined with Trametinib.
Hydroxychloroquine Hydroxychloroquine The metabolism of Hydroxychloroquine can be decreased when combined with Trametinib.
Meloxicam Meloxicam Meloxicam may decrease the excretion rate of Trametinib which could result in a higher serum level.
Pantoprazole Pantoprazole Pantoprazole may decrease the excretion rate of Trametinib which could result in a higher serum level.
Temozolomide Temozolomide Temozolomide may decrease the excretion rate of Trametinib which could result in a higher serum level.
Zaleplon Zaleplon Zaleplon may decrease the excretion rate of Trametinib which could result in a higher serum level.
Perindopril Perindopril Perindopril may decrease the excretion rate of Trametinib which could result in a higher serum level.
Tenofovir Tenofovir Tenofovir may decrease the excretion rate of Trametinib which could result in a higher serum level.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Trametinib which could result in a higher serum level.
Sirolimus Sirolimus The metabolism of Sirolimus can be increased when combined with Trametinib.
Eplerenone Eplerenone Eplerenone may increase the excretion rate of Trametinib which could result in a lower serum level and potentially a reduction in efficacy.
Zonisamide Zonisamide Zonisamide may increase the excretion rate of Trametinib which could result in a lower serum level and potentially a reduction in efficacy.
Aripiprazole Aripiprazole The metabolism of Aripiprazole can be increased when combined with Trametinib.
Atomoxetine Atomoxetine Atomoxetine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Atazanavir Atazanavir Atazanavir may decrease the excretion rate of Trametinib which could result in a higher serum level.
Almotriptan Almotriptan The metabolism of Almotriptan can be decreased when combined with Trametinib.
Rosuvastatin Rosuvastatin The metabolism of Rosuvastatin can be increased when combined with Trametinib.
Emtricitabine Emtricitabine Emtricitabine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Memantine Memantine Memantine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Tadalafil Tadalafil Tadalafil may decrease the excretion rate of Trametinib which could result in a higher serum level.
Progesterone Progesterone The metabolism of Progesterone can be increased when combined with Trametinib.
Apomorphine Injection Apomorphine Injection The metabolism of Apomorphine can be decreased when combined with Trametinib.
Darbepoetin Alfa Injection Darbepoetin Alfa Injection The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Trametinib.
Duloxetine Duloxetine The metabolism of Trametinib can be increased when combined with Duloxetine.
Norethindrone Norethindrone The metabolism of Norethisterone can be increased when combined with Trametinib.
Tinidazole Tinidazole Tinidazole may decrease the excretion rate of Trametinib which could result in a higher serum level.
Cefditoren Cefditoren Cefdinir may decrease the excretion rate of Trametinib which could result in a higher serum level.
Cyanocobalamin Injection Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Trametinib which could result in a higher serum level.
Erlotinib Erlotinib The serum concentration of Erlotinib can be decreased when it is combined with Trametinib.
Eszopiclone Eszopiclone The serum concentration of Eszopiclone can be decreased when it is combined with Trametinib.
Ganciclovir Ganciclovir Ganciclovir may decrease the excretion rate of Trametinib which could result in a higher serum level.
Ribavirin Ribavirin Ribavirin may decrease the excretion rate of Trametinib which could result in a higher serum level.
Valganciclovir Valganciclovir Valganciclovir may decrease the excretion rate of Trametinib which could result in a higher serum level.
Adefovir Adefovir Adefovir may decrease the excretion rate of Trametinib which could result in a higher serum level.
Dextroamphetamine Dextroamphetamine Amphetamine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Ramelteon Ramelteon Ramelteon may decrease the excretion rate of Trametinib which could result in a higher serum level.
Fentanyl Fentanyl Fentanyl may decrease the excretion rate of Trametinib which could result in a higher serum level.
Pregabalin Pregabalin Pregabalin may decrease the excretion rate of Trametinib which could result in a higher serum level.
Ranolazine Ranolazine The metabolism of Trametinib can be increased when combined with Ranolazine.
Rasagiline Rasagiline Rasagiline may decrease the excretion rate of Trametinib which could result in a higher serum level.
Imatinib Imatinib The metabolism of Imatinib can be decreased when combined with Trametinib.
Sitagliptin Sitagliptin The metabolism of Sitagliptin can be decreased when combined with Trametinib.
Varenicline Varenicline Varenicline may decrease the excretion rate of Trametinib which could result in a higher serum level.
Albuterol Albuterol Salbutamol may decrease the excretion rate of Trametinib which could result in a higher serum level.
Paliperidone Paliperidone Paliperidone may decrease the excretion rate of Trametinib which could result in a higher serum level.
Bortezomib Bortezomib The metabolism of Bortezomib can be increased when combined with Trametinib.
Clofarabine Injection Clofarabine Injection Clofarabine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Lubiprostone Lubiprostone Lubiprostone may decrease the excretion rate of Trametinib which could result in a higher serum level.
Pemetrexed Injection Pemetrexed Injection Trametinib may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Retapamulin Retapamulin The metabolism of Retapamulin can be increased when combined with Trametinib.
Sorafenib Sorafenib The metabolism of Sorafenib can be increased when combined with Trametinib.
Sunitinib Sunitinib The metabolism of Sunitinib can be increased when combined with Trametinib.
Lapatinib Lapatinib The metabolism of Lapatinib can be decreased when combined with Trametinib.
Levocetirizine Levocetirizine Levocetirizine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Pegaptanib Injection Pegaptanib Injection Pegaptanib may decrease the excretion rate of Trametinib which could result in a higher serum level.
Dasatinib Dasatinib The metabolism of Dasatinib can be increased when combined with Trametinib.
Azacitidine Injection Azacitidine Injection Azacitidine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Temsirolimus Temsirolimus The metabolism of Temsirolimus can be increased when combined with Trametinib.
Lenalidomide Lenalidomide Lenalidomide may decrease the excretion rate of Trametinib which could result in a higher serum level.
Nilotinib Nilotinib The metabolism of Nilotinib can be increased when combined with Trametinib.
Budesonide Budesonide Budesonide may decrease the excretion rate of Trametinib which could result in a higher serum level.
Desmopressin Desmopressin Desmopressin may decrease the excretion rate of Trametinib which could result in a higher serum level.
Doripenem Injection Doripenem Injection Doripenem may decrease the excretion rate of Trametinib which could result in a higher serum level.
Arsenic Trioxide Injection Arsenic Trioxide Injection Arsenic trioxide may decrease the excretion rate of Trametinib which could result in a higher serum level.
Desvenlafaxine Desvenlafaxine Desvenlafaxine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Cevimeline Cevimeline Cevimeline may decrease the excretion rate of Trametinib which could result in a higher serum level.
Tretinoin Tretinoin The metabolism of Tretinoin can be decreased when combined with Trametinib.
Certolizumab Injection Certolizumab Injection Certolizumab pegol may decrease the excretion rate of Trametinib which could result in a higher serum level.
Ixabepilone Injection Ixabepilone Injection The metabolism of Ixabepilone can be increased when combined with Trametinib.
Irinotecan Injection Irinotecan Injection The metabolism of Irinotecan can be increased when combined with Trametinib.
Daptomycin Injection Daptomycin Injection Daptomycin may decrease the excretion rate of Trametinib which could result in a higher serum level.
Methylnaltrexone Injection Methylnaltrexone Injection Methylnaltrexone may decrease the excretion rate of Trametinib which could result in a higher serum level.
Rufinamide Rufinamide The metabolism of Rufinamide can be increased when combined with Trametinib.
Midazolam Midazolam Midazolam may decrease the excretion rate of Trametinib which could result in a higher serum level.
Dexrazoxane Injection Dexrazoxane Injection Dexrazoxane may decrease the excretion rate of Trametinib which could result in a higher serum level.
Eltrombopag Eltrombopag The metabolism of Eltrombopag can be decreased when combined with Trametinib.
Milnacipran Milnacipran The metabolism of Milnacipran can be increased when combined with Trametinib.
Plerixafor Injection Plerixafor Injection Plerixafor may decrease the excretion rate of Trametinib which could result in a higher serum level.
Fesoterodine Fesoterodine Fesoterodine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Prasugrel Prasugrel Prasugrel may decrease the excretion rate of Trametinib which could result in a higher serum level.
Lacosamide Lacosamide The metabolism of Lacosamide can be increased when combined with Trametinib.
Everolimus Everolimus The metabolism of Everolimus can be increased when combined with Trametinib.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The metabolism of Trametinib can be increased when combined with Tolvaptan.
Dronedarone Dronedarone The metabolism of Dronedarone can be increased when combined with Trametinib.
Pralatrexate Injection Pralatrexate Injection Pralatrexate may decrease the excretion rate of Trametinib which could result in a higher serum level.
Palonosetron Injection Palonosetron Injection Palonosetron may decrease the excretion rate of Trametinib which could result in a higher serum level.
Saxagliptin Saxagliptin Saxagliptin may decrease the excretion rate of Trametinib which could result in a higher serum level.
Telavancin Injection Telavancin Injection Telavancin may decrease the excretion rate of Trametinib which could result in a higher serum level.
Romidepsin Injection Romidepsin Injection The metabolism of Romidepsin can be increased when combined with Trametinib.
Topotecan Topotecan Topotecan may decrease the excretion rate of Trametinib which could result in a higher serum level.
Pazopanib Pazopanib The metabolism of Pazopanib can be increased when combined with Trametinib.
Pitavastatin Pitavastatin The metabolism of Pitavastatin can be decreased when combined with Trametinib.
Albendazole Albendazole The metabolism of Albendazole can be increased when combined with Trametinib.
Ulipristal Ulipristal The metabolism of Ulipristal can be increased when combined with Trametinib.
Levonorgestrel Levonorgestrel The metabolism of Levonorgestrel can be increased when combined with Trametinib.
Dalfampridine Dalfampridine Dalfampridine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Cabazitaxel can be increased when combined with Trametinib.
Ceftaroline Injection Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Trametinib which could result in a higher serum level.
Acetaminophen Injection Acetaminophen Injection Acetaminophen may decrease the excretion rate of Trametinib which could result in a higher serum level.
Ipilimumab Injection Ipilimumab Injection Ipilimumab may decrease the excretion rate of Trametinib which could result in a higher serum level.
Denileukin Diftitox Injection Denileukin Diftitox Injection Aldesleukin may decrease the excretion rate of Trametinib which could result in a higher serum level.
Terbutaline Injection Terbutaline Injection Terbutaline may decrease the excretion rate of Trametinib which could result in a higher serum level.
Busulfan Injection Busulfan Injection The metabolism of Busulfan can be increased when combined with Trametinib.
Roflumilast Roflumilast The metabolism of Trametinib can be increased when combined with Roflumilast.
Linagliptin Linagliptin The metabolism of Linagliptin can be increased when combined with Trametinib.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Cyclophosphamide can be increased when combined with Trametinib.
Rivaroxaban Rivaroxaban Rivaroxaban may decrease the excretion rate of Trametinib which could result in a higher serum level.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Brentuximab vedotin can be increased when combined with Trametinib.
Ruxolitinib Ruxolitinib The metabolism of Trametinib can be increased when combined with Ruxolitinib.
Vandetanib Vandetanib The metabolism of Vandetanib can be increased when combined with Trametinib.
Clobazam Clobazam Clobazam may decrease the excretion rate of Trametinib which could result in a higher serum level.
Vemurafenib Vemurafenib The metabolism of Vemurafenib can be increased when combined with Trametinib.
Deferiprone Deferiprone Deferiprone may decrease the excretion rate of Trametinib which could result in a higher serum level.
Axitinib Axitinib The metabolism of Axitinib can be increased when combined with Trametinib.
Crizotinib Crizotinib The metabolism of Crizotinib can be increased when combined with Trametinib.
Cabergoline Cabergoline The metabolism of Cabergoline can be increased when combined with Trametinib.
Naloxone Injection Naloxone Injection Naloxone may decrease the excretion rate of Trametinib which could result in a higher serum level.
Fondaparinux Injection Fondaparinux Injection Fondaparinux may decrease the excretion rate of Trametinib which could result in a higher serum level.
Enzalutamide Enzalutamide The serum concentration of Enzalutamide can be increased when it is combined with Trametinib.
Mirabegron Mirabegron Mirabegron may decrease the excretion rate of Trametinib which could result in a higher serum level.
Regorafenib Regorafenib The metabolism of Regorafenib can be increased when combined with Trametinib.
Bosutinib Bosutinib The metabolism of Bosutinib can be increased when combined with Trametinib.
Teduglutide Injection Teduglutide Injection Teduglutide may decrease the excretion rate of Trametinib which could result in a higher serum level.
Alogliptin Alogliptin Alogliptin may decrease the excretion rate of Trametinib which could result in a higher serum level.
Ponatinib Ponatinib The metabolism of Ponatinib can be increased when combined with Trametinib.
Pomalidomide Pomalidomide The metabolism of Trametinib can be increased when combined with Pomalidomide.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be increased when combined with Trametinib.
Apixaban Apixaban The metabolism of Apixaban can be decreased when combined with Trametinib.
Canagliflozin Canagliflozin Canagliflozin may increase the excretion rate of Trametinib which could result in a lower serum level and potentially a reduction in efficacy.
Methazolamide Methazolamide Methazolamide may increase the excretion rate of Trametinib which could result in a lower serum level and potentially a reduction in efficacy.
Dabrafenib Dabrafenib The risk or severity of adverse effects can be increased when Trametinib is combined with Dabrafenib.
Levomilnacipran Levomilnacipran The metabolism of Levomilnacipran can be increased when combined with Trametinib.
Ertapenem Injection Ertapenem Injection Ertapenem may decrease the excretion rate of Trametinib which could result in a higher serum level.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Trametinib.
Perampanel Perampanel The metabolism of Perampanel can be increased when combined with Trametinib.
Lomitapide Lomitapide The metabolism of Lomitapide can be increased when combined with Trametinib.
Ketorolac Injection Ketorolac Injection The metabolism of Trametinib can be decreased when combined with Ketorolac.
Sofosbuvir Sofosbuvir Trametinib may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin Dapagliflozin Dapagliflozin may increase the excretion rate of Trametinib which could result in a lower serum level and potentially a reduction in efficacy.
Apremilast Apremilast Apremilast may decrease the excretion rate of Trametinib which could result in a higher serum level.
Droxidopa Droxidopa Droxidopa may decrease the excretion rate of Trametinib which could result in a higher serum level.
Ceritinib Ceritinib The metabolism of Ceritinib can be increased when combined with Trametinib.
Idelalisib Idelalisib The metabolism of Idelalisib can be increased when combined with Trametinib.
Testosterone Injection Testosterone Injection Testosterone may decrease the excretion rate of Trametinib which could result in a higher serum level.
Vorapaxar Vorapaxar The metabolism of Vorapaxar can be increased when combined with Trametinib.
Suvorexant Suvorexant The metabolism of Suvorexant can be increased when combined with Trametinib.
Edoxaban Edoxaban Trametinib may decrease the excretion rate of Edoxaban which could result in a higher serum level.
Olaparib Olaparib The metabolism of Olaparib can be increased when combined with Trametinib.
Methamphetamine Methamphetamine Metamfetamine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Tasimelteon Tasimelteon The metabolism of Tasimelteon can be increased when combined with Trametinib.
Riociguat Riociguat The metabolism of Riociguat can be decreased when combined with Trametinib.
Nintedanib Nintedanib The metabolism of Nintedanib can be increased when combined with Trametinib.
Palbociclib Palbociclib The metabolism of Palbociclib can be increased when combined with Trametinib.
Panobinostat Panobinostat The metabolism of Panobinostat can be increased when combined with Trametinib.
Haloperidol Injection Haloperidol Injection Haloperidol may decrease the excretion rate of Trametinib which could result in a higher serum level.
Amiloride Amiloride Amiloride may increase the excretion rate of Trametinib which could result in a lower serum level and potentially a reduction in efficacy.
Macitentan Macitentan Trametinib may decrease the excretion rate of Macitentan which could result in a higher serum level.
Sonidegib Sonidegib The metabolism of Sonidegib can be increased when combined with Trametinib.
Ziprasidone Injection Ziprasidone Injection The metabolism of Ziprasidone can be increased when combined with Trametinib.
Penicillin G Procaine Injection Penicillin G Procaine Injection Trametinib may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Cobimetinib Cobimetinib The metabolism of Cobimetinib can be increased when combined with Trametinib.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be increased when combined with Trametinib.
Osimertinib Osimertinib The metabolism of Osimertinib can be increased when combined with Trametinib.
Alectinib Alectinib The metabolism of Alectinib can be increased when combined with Trametinib.
Ixazomib Ixazomib The metabolism of Ixazomib can be increased when combined with Trametinib.
Lesinurad Lesinurad Trametinib may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Trametinib which could result in a higher serum level.
Brivaracetam Injection Brivaracetam Injection Brivaracetam may decrease the excretion rate of Trametinib which could result in a higher serum level.
Venetoclax Venetoclax The metabolism of Venetoclax can be increased when combined with Trametinib.
Selexipag Selexipag The metabolism of Selexipag can be decreased when combined with Trametinib.
Furosemide Injection Furosemide Injection Furosemide may increase the excretion rate of Trametinib which could result in a lower serum level and potentially a reduction in efficacy.
Lixisenatide Injection Lixisenatide Injection Trametinib may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Ribociclib Ribociclib The metabolism of Ribociclib can be increased when combined with Trametinib.
Brigatinib Brigatinib The metabolism of Brigatinib can be increased when combined with Trametinib.
Doxepin (Insomnia) Doxepin (Insomnia) Doxepin may decrease the excretion rate of Trametinib which could result in a higher serum level.
Deutetrabenazine Deutetrabenazine Trametinib may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level.
Valbenazine Valbenazine Trametinib may decrease the excretion rate of Valbenazine which could result in a higher serum level.
Naldemedine Naldemedine Trametinib may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Midostaurin Midostaurin The metabolism of Midostaurin can be increased when combined with Trametinib.
Neratinib Neratinib The metabolism of Neratinib can be increased when combined with Trametinib.
Enasidenib Enasidenib The metabolism of Enasidenib can be increased when combined with Trametinib.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Fosaprepitant can be increased when combined with Trametinib.
Benznidazole Benznidazole Trametinib may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Copanlisib Injection Copanlisib Injection The metabolism of Copanlisib can be increased when combined with Trametinib.
Delafloxacin Delafloxacin Trametinib may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Abemaciclib Abemaciclib The metabolism of Abemaciclib can be increased when combined with Trametinib.
Acalabrutinib Acalabrutinib The metabolism of Acalabrutinib can be increased when combined with Trametinib.
Ertugliflozin Ertugliflozin Ertugliflozin may increase the excretion rate of Trametinib which could result in a lower serum level and potentially a reduction in efficacy.
Buprenorphine Injection Buprenorphine Injection The metabolism of Buprenorphine can be decreased when combined with Trametinib.
Apalutamide Apalutamide The serum concentration of Apalutamide can be increased when it is combined with Trametinib.
Baricitinib Baricitinib The metabolism of Baricitinib can be increased when combined with Trametinib.
Lofexidine Lofexidine Lofexidine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Plazomicin Injection Plazomicin Injection Trametinib may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Ivosidenib Ivosidenib The metabolism of Ivosidenib can be increased when combined with Trametinib.
Elagolix Elagolix The metabolism of Elagolix can be decreased when combined with Trametinib.
Dacomitinib Dacomitinib The metabolism of Dacomitinib can be increased when combined with Trametinib.
Duvelisib Duvelisib The metabolism of Duvelisib can be increased when combined with Trametinib.
Stiripentol Stiripentol Trametinib may decrease the excretion rate of Stiripentol which could result in a higher serum level.
Gilteritinib Gilteritinib The metabolism of Gilteritinib can be increased when combined with Trametinib.
Glasdegib Glasdegib The metabolism of Glasdegib can be decreased when combined with Trametinib.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Trametinib.
Methoxy Polyethylene Glycol-Epoetin Beta Injection Methoxy Polyethylene Glycol-Epoetin Beta Injection The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Trametinib.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be increased when combined with Trametinib.
Prucalopride Prucalopride The metabolism of Trametinib can be increased when combined with Prucalopride.
Siponimod Siponimod The metabolism of Siponimod can be increased when combined with Trametinib.
Acyclovir Ophthalmic Acyclovir Ophthalmic Acyclovir may decrease the excretion rate of Trametinib which could result in a higher serum level.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be increased when combined with Trametinib.
Alpelisib Alpelisib The metabolism of Alpelisib can be increased when combined with Trametinib.
Solriamfetol Solriamfetol Trametinib may decrease the excretion rate of Solriamfetol which could result in a higher serum level.
Entrectinib Entrectinib The metabolism of Entrectinib can be increased when combined with Trametinib.
Pexidartinib Pexidartinib The metabolism of Pexidartinib can be increased when combined with Trametinib.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Trametinib.
Pitolisant Pitolisant Trametinib may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Lefamulin Lefamulin The metabolism of Lefamulin can be increased when combined with Trametinib.
Phenytoin Injection Phenytoin Injection The metabolism of Phenytoin can be decreased when combined with Trametinib.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Fosphenytoin can be increased when combined with Trametinib.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be increased when combined with Trametinib.
Lumateperone Lumateperone The serum concentration of Lumateperone can be decreased when it is combined with Trametinib.
Tazemetostat Tazemetostat The metabolism of Tazemetostat can be increased when combined with Trametinib.
Ozanimod Ozanimod The metabolism of Ozanimod can be decreased when combined with Trametinib.
Selumetinib Selumetinib The metabolism of Selumetinib can be decreased when combined with Trametinib.
Rimegepant Rimegepant The metabolism of Rimegepant can be increased when combined with Trametinib.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Trametinib.
Selpercatinib Selpercatinib The serum concentration of Selpercatinib can be decreased when it is combined with Trametinib.
Capmatinib Capmatinib The serum concentration of Capmatinib can be decreased when it is combined with Trametinib.
Lemborexant Lemborexant The serum concentration of Lemborexant can be decreased when it is combined with Trametinib.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Drospirenone can be increased when combined with Trametinib.
Viloxazine Viloxazine Trametinib may decrease the excretion rate of Viloxazine which could result in a higher serum level.
Tobramycin Injection Tobramycin Injection Tobramycin may decrease the excretion rate of Trametinib which could result in a higher serum level.
Theophylline Theophylline The metabolism of Theophylline can be increased when combined with Trametinib.
Fenoprofen Fenoprofen Fenoprofen may decrease the excretion rate of Trametinib which could result in a higher serum level.
Indomethacin Indomethacin Indomethacin may decrease the excretion rate of Trametinib which could result in a higher serum level.
Mefenamic Acid Mefenamic Acid Mefenamic acid may decrease the excretion rate of Trametinib which could result in a higher serum level.
Naproxen Naproxen The metabolism of Naproxen can be decreased when combined with Trametinib.
Tolmetin Tolmetin Tolmetin may decrease the excretion rate of Trametinib which could result in a higher serum level.
Sulindac Sulindac Sulindac may decrease the excretion rate of Trametinib which could result in a higher serum level.
Isotretinoin Isotretinoin Isotretinoin may decrease the excretion rate of Trametinib which could result in a higher serum level.
Sucralfate Sucralfate Sucralfate may decrease the excretion rate of Trametinib which could result in a higher serum level.
Floxuridine Floxuridine Floxuridine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Metaxalone Metaxalone Metaxalone may decrease the excretion rate of Trametinib which could result in a higher serum level.
Methotrexate Injection Methotrexate Injection The metabolism of Trametinib can be increased when combined with Methotrexate.
Chlorpromazine Chlorpromazine The metabolism of Trametinib can be increased when combined with Chlorpromazine.
Diazepam Diazepam Diazepam may decrease the excretion rate of Trametinib which could result in a higher serum level.
Oxazepam Oxazepam Oxazepam may decrease the excretion rate of Trametinib which could result in a higher serum level.
Flurazepam Flurazepam Flurazepam may decrease the excretion rate of Trametinib which could result in a higher serum level.
Clorazepate Clorazepate Clorazepic acid may decrease the excretion rate of Trametinib which could result in a higher serum level.
Lorazepam Lorazepam The metabolism of Trametinib can be increased when combined with Lorazepam.
Carmustine Carmustine Carmustine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Amantadine Amantadine Amantadine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Codeine Codeine Codeine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Phenelzine Phenelzine Phenelzine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Tetracycline Tetracycline Tetracycline may decrease the excretion rate of Trametinib which could result in a higher serum level.
Prochlorperazine Prochlorperazine The metabolism of Prochlorperazine can be increased when combined with Trametinib.
Bleomycin Bleomycin Bleomycin may decrease the excretion rate of Trametinib which could result in a higher serum level.
Dapsone Dapsone The metabolism of Dapsone can be decreased when combined with Trametinib.
Sulfadiazine Sulfadiazine The metabolism of Sulfadiazine can be decreased when combined with Trametinib.
Methadone Methadone The metabolism of Methadone can be decreased when combined with Trametinib.
Benztropine Benztropine Benzatropine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Maprotiline Maprotiline Maprotiline may decrease the excretion rate of Trametinib which could result in a higher serum level.
Ibuprofen Ibuprofen The metabolism of Ibuprofen can be decreased when combined with Trametinib.
Azathioprine Azathioprine Azathioprine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Phentermine Phentermine The metabolism of Phentermine can be increased when combined with Trametinib.
Methylphenidate Methylphenidate Methylphenidate may decrease the excretion rate of Trametinib which could result in a higher serum level.
Sulfasalazine Sulfasalazine Sulfasalazine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Doxorubicin Doxorubicin The metabolism of Doxorubicin can be increased when combined with Trametinib.
Phenazopyridine Phenazopyridine Phenazopyridine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Carbamazepine Carbamazepine The metabolism of Carbamazepine can be increased when combined with Trametinib.
Methyldopa Methyldopa Methyldopa may decrease the excretion rate of Trametinib which could result in a higher serum level.
Clonidine Clonidine The metabolism of Clonidine can be increased when combined with Trametinib.
Hydralazine Hydralazine Hydralazine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Cimetidine Cimetidine Cimetidine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Gentamicin Injection Gentamicin Injection Gentamicin may decrease the excretion rate of Trametinib which could result in a higher serum level.
Warfarin Warfarin The metabolism of Warfarin can be increased when combined with Trametinib.
Clonazepam Clonazepam The metabolism of Clonazepam can be increased when combined with Trametinib.
Loperamide Loperamide The metabolism of Loperamide can be decreased when combined with Trametinib.
Promethazine Promethazine Promethazine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Meclofenamate Meclofenamate Meclofenamic acid may decrease the excretion rate of Trametinib which could result in a higher serum level.
Nitrofurantoin Nitrofurantoin Nitrofurantoin may decrease the excretion rate of Trametinib which could result in a higher serum level.
Digoxin Digoxin Trametinib may decrease the excretion rate of Digoxin which could result in a higher serum level.
Chloroquine Chloroquine The metabolism of Chloroquine can be decreased when combined with Trametinib.
Quinine Quinine The metabolism of Quinine can be decreased when combined with Trametinib.
Triamterene Triamterene Triamterene may decrease the excretion rate of Trametinib which could result in a higher serum level.
Chlorothiazide Chlorothiazide Chlorothiazide may increase the excretion rate of Trametinib which could result in a lower serum level and potentially a reduction in efficacy.
Chlorthalidone Chlorthalidone Chlorthalidone may increase the excretion rate of Trametinib which could result in a lower serum level and potentially a reduction in efficacy.
Metolazone Metolazone Metolazone may increase the excretion rate of Trametinib which could result in a lower serum level and potentially a reduction in efficacy.
Isosorbide Isosorbide The metabolism of Isosorbide can be increased when combined with Trametinib.
Clindamycin Injection Clindamycin Injection The metabolism of Clindamycin can be increased when combined with Trametinib.
Secobarbital Secobarbital Secobarbital may decrease the excretion rate of Trametinib which could result in a higher serum level.
Desipramine Desipramine Desipramine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Amitriptyline Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Trametinib.
Imipramine Imipramine Imipramine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Probenecid Probenecid Probenecid may decrease the excretion rate of Trametinib which could result in a higher serum level.
Quinidine Quinidine The metabolism of Quinidine can be increased when combined with Trametinib.
Procainamide Procainamide Trametinib may decrease the excretion rate of Procainamide which could result in a higher serum level.
Isoniazid Isoniazid Isoniazid may decrease the excretion rate of Trametinib which could result in a higher serum level.
Pyrazinamide Pyrazinamide Pyrazinamide may decrease the excretion rate of Trametinib which could result in a higher serum level.
Disopyramide Disopyramide Disopyramide may decrease the excretion rate of Trametinib which could result in a higher serum level.
Tamoxifen Tamoxifen The metabolism of Tamoxifen can be increased when combined with Trametinib.
Butabarbital Butabarbital Butabarbital may decrease the excretion rate of Trametinib which could result in a higher serum level.
Liothyronine Liothyronine Liothyronine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Methimazole Methimazole Methimazole may decrease the excretion rate of Trametinib which could result in a higher serum level.
Chlorpropamide Chlorpropamide Chlorpropamide may decrease the excretion rate of Trametinib which could result in a higher serum level.
Tolbutamide Tolbutamide The metabolism of Tolbutamide can be decreased when combined with Trametinib.
Tolazamide Tolazamide Tolazamide may decrease the excretion rate of Trametinib which could result in a higher serum level.
Baclofen Baclofen Baclofen may decrease the excretion rate of Trametinib which could result in a higher serum level.
Ethambutol Ethambutol Ethambutol may decrease the excretion rate of Trametinib which could result in a higher serum level.
Methyclothiazide Methyclothiazide Methyclothiazide may increase the excretion rate of Trametinib which could result in a lower serum level and potentially a reduction in efficacy.
Hydrochlorothiazide Hydrochlorothiazide Hydrochlorothiazide may decrease the excretion rate of Trametinib which could result in a higher serum level.
Chlorzoxazone Chlorzoxazone Chlorzoxazone may decrease the excretion rate of Trametinib which could result in a higher serum level.
Pyridoxine Pyridoxine Pyridoxine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Folic Acid Folic Acid Folic acid may decrease the excretion rate of Trametinib which could result in a higher serum level.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) Propranolol may decrease the excretion rate of Trametinib which could result in a higher serum level.
Nortriptyline Nortriptyline The metabolism of Nortriptyline can be increased when combined with Trametinib.
Spironolactone Spironolactone Spironolactone may increase the excretion rate of Trametinib which could result in a lower serum level and potentially a reduction in efficacy.
Amphotericin B Injection Amphotericin B Injection Amphotericin B may decrease the excretion rate of Trametinib which could result in a higher serum level.
Phytonadione Phytonadione Phylloquinone may decrease the excretion rate of Trametinib which could result in a higher serum level.
Amikacin Injection Amikacin Injection Amikacin may decrease the excretion rate of Trametinib which could result in a higher serum level.
Nadolol Nadolol Nadolol may decrease the excretion rate of Trametinib which could result in a higher serum level.
Allopurinol Allopurinol Allopurinol may decrease the excretion rate of Trametinib which could result in a higher serum level.
Flavoxate Flavoxate Flavoxate may decrease the excretion rate of Trametinib which could result in a higher serum level.
Fluorouracil Injection Fluorouracil Injection The metabolism of Fluorouracil can be decreased when combined with Trametinib.
Colchicine Colchicine Colchicine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Cefaclor Cefaclor Cefaclor may decrease the excretion rate of Trametinib which could result in a higher serum level.
Cefadroxil Cefadroxil Cefadroxil may decrease the excretion rate of Trametinib which could result in a higher serum level.
Cefazolin Injection Cefazolin Injection Cefazolin may decrease the excretion rate of Trametinib which could result in a higher serum level.
Cephalexin Cephalexin Cephalexin may decrease the excretion rate of Trametinib which could result in a higher serum level.
Cefoxitin Injection Cefoxitin Injection Cefoxitin may decrease the excretion rate of Trametinib which could result in a higher serum level.
Dacarbazine Dacarbazine Dacarbazine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Acetazolamide Acetazolamide Acetazolamide may increase the excretion rate of Trametinib which could result in a lower serum level and potentially a reduction in efficacy.
Cefotaxime Injection Cefotaxime Injection Cefotaxime may decrease the excretion rate of Trametinib which could result in a higher serum level.
Calcitonin Salmon Injection Calcitonin Salmon Injection Salmon calcitonin may decrease the excretion rate of Trametinib which could result in a higher serum level.
Pyrantel Pyrantel Trametinib may decrease the excretion rate of Pyrantel which could result in a higher serum level.
Thiotepa Injection Thiotepa Injection The metabolism of Thiotepa can be increased when combined with Trametinib.
Vincristine Injection Vincristine Injection The metabolism of Vincristine can be increased when combined with Trametinib.
Vinblastine Vinblastine The metabolism of Vinblastine can be increased when combined with Trametinib.
Ethacrynic Acid Ethacrynic Acid Etacrynic acid may decrease the excretion rate of Trametinib which could result in a higher serum level.
Colistimethate Injection Colistimethate Injection Colistimethate may decrease the excretion rate of Trametinib which could result in a higher serum level.
Metoprolol Metoprolol The metabolism of Trametinib can be increased when combined with Metoprolol.
Aspirin Aspirin Acetylsalicylic acid may decrease the excretion rate of Trametinib which could result in a higher serum level.
Salsalate Salsalate Salsalate may decrease the excretion rate of Trametinib which could result in a higher serum level.
Alprazolam Alprazolam Alprazolam may decrease the excretion rate of Trametinib which could result in a higher serum level.
Temazepam Temazepam Temazepam may decrease the excretion rate of Trametinib which could result in a higher serum level.
Triazolam Triazolam Triazolam may decrease the excretion rate of Trametinib which could result in a higher serum level.
Dicyclomine Dicyclomine Dicyclomine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Propantheline Propantheline Propantheline may decrease the excretion rate of Trametinib which could result in a higher serum level.
Trimethoprim Trimethoprim Trimethoprim may decrease the excretion rate of Trametinib which could result in a higher serum level.
Diltiazem Diltiazem The metabolism of Diltiazem can be decreased when combined with Trametinib.
Nifedipine Nifedipine Nifedipine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Timolol Timolol Timolol may decrease the excretion rate of Trametinib which could result in a higher serum level.
Verapamil Verapamil The metabolism of Verapamil can be decreased when combined with Trametinib.
Pindolol Pindolol Pindolol may decrease the excretion rate of Trametinib which could result in a higher serum level.
Cisplatin Injection Cisplatin Injection Trametinib may decrease the excretion rate of Cisplatin which could result in a higher serum level.
Diflunisal Diflunisal Diflunisal may decrease the excretion rate of Trametinib which could result in a higher serum level.
Piroxicam Piroxicam The metabolism of Piroxicam can be decreased when combined with Trametinib.
Bumetanide Bumetanide Bumetanide may increase the excretion rate of Trametinib which could result in a lower serum level and potentially a reduction in efficacy.
Etoposide Etoposide The metabolism of Etoposide can be increased when combined with Trametinib.
Glipizide Glipizide Glipizide may decrease the excretion rate of Trametinib which could result in a higher serum level.
Indapamide Indapamide Indapamide may increase the excretion rate of Trametinib which could result in a lower serum level and potentially a reduction in efficacy.
Amoxicillin Amoxicillin Amoxicillin may decrease the excretion rate of Trametinib which could result in a higher serum level.
Oxacillin Injection Oxacillin Injection Oxacillin may decrease the excretion rate of Trametinib which could result in a higher serum level.
Pentoxifylline Pentoxifylline Pentoxifylline may decrease the excretion rate of Trametinib which could result in a higher serum level.
Pentamidine Injection Pentamidine Injection Pentamidine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Ceftriaxone Injection Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Trametinib which could result in a higher serum level.
Labetalol Labetalol Labetalol may decrease the excretion rate of Trametinib which could result in a higher serum level.
Auranofin Auranofin Auranofin may decrease the excretion rate of Trametinib which could result in a higher serum level.
Leuprolide Injection Leuprolide Injection Leuprolide may decrease the excretion rate of Trametinib which could result in a higher serum level.
Gemfibrozil Gemfibrozil Gemfibrozil may decrease the excretion rate of Trametinib which could result in a higher serum level.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Trametinib which could result in a higher serum level.
Ceftazidime Injection Ceftazidime Injection Ceftazidime may decrease the excretion rate of Trametinib which could result in a higher serum level.
Ketoprofen Ketoprofen Ketoprofen may decrease the excretion rate of Trametinib which could result in a higher serum level.
Cefotetan Injection Cefotetan Injection Cefotetan may decrease the excretion rate of Trametinib which could result in a higher serum level.
Pimozide Pimozide The metabolism of Pimozide can be increased when combined with Trametinib.
Flurbiprofen Flurbiprofen Flurbiprofen may decrease the excretion rate of Trametinib which could result in a higher serum level.
Amiodarone Amiodarone The metabolism of Amiodarone can be increased when combined with Trametinib.
Aztreonam Injection Aztreonam Injection Aztreonam may decrease the excretion rate of Trametinib which could result in a higher serum level.
Buspirone Buspirone Buspirone may decrease the excretion rate of Trametinib which could result in a higher serum level.
Lovastatin Lovastatin The metabolism of Lovastatin can be decreased when combined with Trametinib.
Ciprofloxacin Ciprofloxacin Ciprofloxacin may decrease the excretion rate of Trametinib which could result in a higher serum level.
Mesalamine Mesalamine Mesalazine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Diclofenac Diclofenac The metabolism of Diclofenac can be decreased when combined with Trametinib.
Clozapine Clozapine Clozapine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Estazolam Estazolam Estazolam may decrease the excretion rate of Trametinib which could result in a higher serum level.
Didanosine Didanosine Didanosine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Pentostatin Injection Pentostatin Injection Pentostatin may decrease the excretion rate of Trametinib which could result in a higher serum level.
Etodolac Etodolac Etodolac may decrease the excretion rate of Trametinib which could result in a higher serum level.
Fosinopril Fosinopril Fosinopril may decrease the excretion rate of Trametinib which could result in a higher serum level.
Nabumetone Nabumetone Nabumetone may decrease the excretion rate of Trametinib which could result in a higher serum level.
Simvastatin Simvastatin The metabolism of Simvastatin can be decreased when combined with Trametinib.
Epoetin Alfa, Injection Epoetin Alfa, Injection The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Trametinib.
Amlodipine Amlodipine The metabolism of Amlodipine can be increased when combined with Trametinib.
Teniposide Injection Teniposide Injection The metabolism of Teniposide can be increased when combined with Trametinib.
Lisinopril Lisinopril Lisinopril may decrease the excretion rate of Trametinib which could result in a higher serum level.
Oxaprozin Oxaprozin Oxaprozin may decrease the excretion rate of Trametinib which could result in a higher serum level.
Bisoprolol Bisoprolol Bisoprolol may decrease the excretion rate of Trametinib which could result in a higher serum level.
Zolpidem Zolpidem The metabolism of Zolpidem can be increased when combined with Trametinib.
Doxazosin Doxazosin The metabolism of Doxazosin can be increased when combined with Trametinib.
Isradipine Isradipine Isradipine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Omeprazole Omeprazole The metabolism of Omeprazole can be decreased when combined with Trametinib.
Cisapride Cisapride The metabolism of Cisapride can be decreased when combined with Trametinib.
Fluvastatin Fluvastatin The metabolism of Fluvastatin can be decreased when combined with Trametinib.
Venlafaxine Venlafaxine Venlafaxine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Famciclovir Famciclovir The metabolism of Famciclovir can be increased when combined with Trametinib.
Fluvoxamine Fluvoxamine Fluvoxamine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Nefazodone Nefazodone Nefazodone may decrease the excretion rate of Trametinib which could result in a higher serum level.
Lamotrigine Lamotrigine Lamotrigine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Valacyclovir Valacyclovir Valaciclovir may decrease the excretion rate of Trametinib which could result in a higher serum level.
Tramadol Tramadol The metabolism of Trametinib can be increased when combined with Tramadol.
Vinorelbine Injection Vinorelbine Injection The metabolism of Vinorelbine can be increased when combined with Trametinib.
Carboplatin Injection Carboplatin Injection Carboplatin may decrease the excretion rate of Trametinib which could result in a higher serum level.
Lansoprazole Lansoprazole The metabolism of Lansoprazole can be decreased when combined with Trametinib.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ifosfamide can be increased when combined with Trametinib.
Nicardipine Nicardipine The metabolism of Nicardipine can be decreased when combined with Trametinib.
Bupropion Bupropion Bupropion may decrease the excretion rate of Trametinib which could result in a higher serum level.
Ticlopidine Ticlopidine The metabolism of Trametinib can be increased when combined with Ticlopidine.
Metformin Metformin Metformin may decrease the excretion rate of Trametinib which could result in a higher serum level.
Nisoldipine Nisoldipine Nisoldipine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Lamivudine Lamivudine Lamivudine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Acarbose Acarbose Acarbose may decrease the excretion rate of Trametinib which could result in a higher serum level.
Anastrozole Anastrozole The metabolism of Anastrozole can be decreased when combined with Trametinib.
Gemcitabine Injection Gemcitabine Injection Gemcitabine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Docetaxel Injection Docetaxel Injection The metabolism of Docetaxel can be increased when combined with Trametinib.
Cidofovir Injection Cidofovir Injection Cidofovir may decrease the excretion rate of Trametinib which could result in a higher serum level.
Meropenem Injection Meropenem Injection Meropenem may decrease the excretion rate of Trametinib which could result in a higher serum level.
Clomipramine Clomipramine The metabolism of Trametinib can be increased when combined with Clomipramine.
Zafirlukast Zafirlukast The metabolism of Zafirlukast can be decreased when combined with Trametinib.
Fosfomycin Fosfomycin Fosfomycin may decrease the excretion rate of Trametinib which could result in a higher serum level.
Topiramate Topiramate Topiramate may decrease the excretion rate of Trametinib which could result in a higher serum level.
Pramipexole Pramipexole Pramipexole may decrease the excretion rate of Trametinib which could result in a higher serum level.
Azithromycin Azithromycin The metabolism of Azithromycin can be increased when combined with Trametinib.
Nilutamide Nilutamide Nilutamide may decrease the excretion rate of Trametinib which could result in a higher serum level.
Flutamide Flutamide Flutamide may decrease the excretion rate of Trametinib which could result in a higher serum level.
Selegiline Selegiline The metabolism of Selegiline can be decreased when combined with Trametinib.
Bicalutamide Bicalutamide The metabolism of Bicalutamide can be increased when combined with Trametinib.
Irbesartan Irbesartan The metabolism of Irbesartan can be decreased when combined with Trametinib.
Tamsulosin Tamsulosin Tamsulosin may decrease the excretion rate of Trametinib which could result in a higher serum level.
Quetiapine Quetiapine Quetiapine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Cefepime Injection Cefepime Injection Cefepime may decrease the excretion rate of Trametinib which could result in a higher serum level.
Cefprozil Cefprozil Cefprozil may decrease the excretion rate of Trametinib which could result in a higher serum level.
Cefpodoxime Cefpodoxime Cefpodoxime may decrease the excretion rate of Trametinib which could result in a higher serum level.
Cetirizine Cetirizine Cetirizine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Tolcapone Tolcapone Tolcapone may decrease the excretion rate of Trametinib which could result in a higher serum level.
Capecitabine Capecitabine Capecitabine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Abacavir Abacavir Abacavir may decrease the excretion rate of Trametinib which could result in a higher serum level.
Pioglitazone Pioglitazone The serum concentration of Pioglitazone can be increased when it is combined with Trametinib.
Celecoxib Celecoxib The metabolism of Celecoxib can be decreased when combined with Trametinib.
Rosiglitazone Rosiglitazone The metabolism of Rosiglitazone can be decreased when combined with Trametinib.
Tolterodine Tolterodine Tolterodine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Oseltamivir Oseltamivir Oseltamivir may decrease the excretion rate of Trametinib which could result in a higher serum level.
Balsalazide Balsalazide Balsalazide may decrease the excretion rate of Trametinib which could result in a higher serum level.
Nateglinide Nateglinide Nateglinide may decrease the excretion rate of Trametinib which could result in a higher serum level.
Rabeprazole Rabeprazole Rabeprazole may decrease the excretion rate of Trametinib which could result in a higher serum level.
Terbinafine Terbinafine The metabolism of Terbinafine can be decreased when combined with Trametinib.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists

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