Trametinib
Generic name: Pronounced as (tra me' ti nib)
Medical Content Reviewed By HelloPharmacist Staff
Last Revised - 06/15/2018
On this page
- Why is this medication prescribed?
- How should this medicine be used?
- Other uses for this medicine
- What special precautions should I follow?
- What special dietary instructions should I follow?
- What should I do if I forget a dose?
- What side effects can this medication cause?
- What should I know about STORAGE and DISPOSAL of this medication?
- What should I do in case of OVERDOSE?
- What OTHER INFORMATION should I know?
- Drug interactions
Why is this medication prescribed?
Trametinib is used alone or in combination with dabrafenib (Tafinlar) to treat a certain types of melanoma (a type of skin cancer) that cannot be treated with surgery or that has spread to other parts of the body. It is used in combination with dabrafenib to treat and prevent the return of a certain type of melanoma after surgery to remove it and any affected lymph nodes. Trametinib is also used in combination with dabrafenib to treat a certain type of non-small-cell lung cancer (NSCLC) that has spread to nearby tissues or to other parts of the body. It is used in combination with dabrafenib to treat a certain type of thyroid cancer that has spread to nearby tissues or to other parts of the body, which cannot be treated with other therapies. Trametinib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps stop the spread of cancer cells.
=
How should this medicine be used?
Trametinib comes as a tablet to take by mouth. It is usually taken once a day on an empty stomach, at least 1 hour before or 2 hours after a meal. Take trametinib at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take trametinib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Do not stop taking trametinib without talking to your doctor.
Your doctor may adjust your dose of trametinib depending on your response to treatment and any side effects that you experience. Talk to your doctor about how you are feeling during your treatment.
Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.
Other uses for this medicine
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What special precautions should I follow?
Before taking trametinib,
-
tell your doctor and pharmacist if you are allergic to trametinib, any other medications, or any of the ingredients in trametinib tablets. Ask your pharmacist for a list of the ingredients.
-
tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.
-
tell your doctor if you have or have ever had lung disease or breathing problems; diabetes; bleeding problems or blood clots; colitis (inflammation of the colon); stomach problems; high blood pressure; heart, eye, liver, or kidney disease; or any other medical conditions.
-
tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while you are taking trametinib. You should use birth control to prevent pregnancy during your treatment with trametinib and for 4 months after your final dose. Talk to your doctor about birth control methods that will work for you. If you become pregnant while taking trametinib, call your doctor. Trametinib may harm the fetus.
-
tell your doctor if you are breastfeeding or plan to breastfeed. You should not breastfeed while taking trametinib and for 4 months after your final dose.
-
you should know that this medication may decrease fertility in women. Talk to your doctor about the risks of taking trametinib.
What special dietary instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
What should I do if I forget a dose?
Take the missed dose as soon as you remember it. However, if it is less than 12 hours until your next scheduled dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can this medication cause?
-
Trametinib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
-
dry skin
-
sores on the mouth and tongue
-
dry mouth
-
vomiting
-
loss of appetite
-
change in ability to taste food
-
tiredness
-
-
Some side effects can be serious. If you experience any of these symptoms, stop taking trametinib and call your doctor immediately:
-
unusual bleeding or bruising
-
bloody or black, tarry stools
-
coughing up or vomiting blood or material that looks like coffee grounds
-
nosebleed
-
severe diarrhea
-
stomach pain
-
nausea
-
fever
-
chills
-
rapid, irregular, or pounding heartbeat
-
difficulty breathing
-
chest pain
-
swelling of the face, arms, legs, ankles, or feet
-
dizziness, lightheadedness, or weakness
-
shortness of breath
-
leg pain, swelling, tenderness, redness, or warmth
-
severe headache
-
cough
-
blurred vision
-
change in vision, including seeing halos (blurred outline around objects) or colored dots
-
loss of vision
-
eye pain
-
dry, red, or swollen eyes
-
rash, red skin, or pimples
-
wart
-
a reddish bump that bleeds or does not heal
-
change in size or color of a mole
-
itching
-
blisters, ulcers, or sores on the skin or nails
-
tingling, burning, redness, swelling, peeling or flaking, blisters, or sores on the palms of the hands or soles of the feet
-
frequent urination
-
increased thirst
-
-
Trametinib may increase the risk that you will develop new skin cancers or other cancers. Talk to your doctor about the risks of taking this medication.
-
Trametinib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
-
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
What should I know about STORAGE and DISPOSAL of this medication?
Keep this medication in the container it came in, tightly closed, away from moisture and light, and out of the reach of children. Do not place the tablets in other containers, such as daily or weekly pill boxes. Store it in a refrigerator, but do not freeze it. Do not remove the desiccant (small packet included with medication to absorb moisture) from your bottle.
It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.
What should I do in case of OVERDOSE?
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
Symptoms of overdose may include the following:
-
vision problems
What OTHER INFORMATION should I know?
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests before and during your treatment to see if it is safe for you to receive trametinib and to check your body's response to trametinib. Your doctor will also check your skin for any changes before you begin treatment, every 2 months during your treatment, and for up to 6 months after treatment. Your doctor will also check your blood pressure from time to time as needed.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Drug interactions
Drug | Interaction |
---|---|
Repaglinide | Repaglinide The metabolism of Repaglinide can be decreased when combined with Trametinib. |
Montelukast | Montelukast The metabolism of Montelukast can be decreased when combined with Trametinib. |
Atorvastatin | Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Trametinib. |
Aminophylline | Aminophylline The metabolism of Aminophylline can be increased when combined with Trametinib. |
Cilostazol | Cilostazol Cilostazol may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Estrogen and Progestin (Oral Contraceptives) | Estrogen and Progestin (Oral Contraceptives) Conjugated estrogens may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Fenofibrate | Fenofibrate The metabolism of Trametinib can be increased when combined with Fenofibrate. |
Guanfacine | Guanfacine Guanfacine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Magnesium Hydroxide | Magnesium Hydroxide Trametinib may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level. |
Mycophenolate | Mycophenolate Mycophenolic acid may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Olsalazine | Olsalazine Olsalazine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Paregoric | Paregoric The metabolism of Morphine can be decreased when combined with Trametinib. |
Potassium | Potassium Potassium cation may increase the excretion rate of Trametinib which could result in a lower serum level and potentially a reduction in efficacy. |
Prednisone | Prednisone Prednisone may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Ranitidine | Ranitidine Ranitidine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Reserpine | Reserpine Reserpine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Rizatriptan | Rizatriptan Rizatriptan may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Sumatriptan | Sumatriptan Sumatriptan may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Tacrolimus | Tacrolimus The metabolism of Tacrolimus can be increased when combined with Trametinib. |
Ampicillin Injection | Ampicillin Injection Ampicillin may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Doxycycline Injection | Doxycycline Injection Doxycycline may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Fluconazole Injection | Fluconazole Injection Fluconazole may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Foscarnet Injection | Foscarnet Injection Foscarnet may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Hydromorphone Injection | Hydromorphone Injection Hydromorphone may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Levofloxacin Injection | Levofloxacin Injection Levofloxacin may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Meperidine Injection | Meperidine Injection The metabolism of Trametinib can be increased when combined with Meperidine. |
Metoclopramide Injection | Metoclopramide Injection Metoclopramide may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Morphine Injection | Morphine Injection The metabolism of Morphine can be decreased when combined with Trametinib. |
Pamidronate Injection | Pamidronate Injection Pamidronic acid may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Vancomycin Injection | Vancomycin Injection Trametinib may decrease the excretion rate of Vancomycin which could result in a higher serum level. |
Zidovudine Injection | Zidovudine Injection The metabolism of Zidovudine can be decreased when combined with Trametinib. |
Altretamine | Altretamine Amphetamine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Cefuroxime | Cefuroxime Cefuroxime may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Cyclosporine | Cyclosporine The metabolism of Cyclosporine can be increased when combined with Trametinib. |
Torsemide | Torsemide The metabolism of Torasemide can be decreased when combined with Trametinib. |
Dofetilide | Dofetilide The metabolism of Dofetilide can be increased when combined with Trametinib. |
Hydroxychloroquine | Hydroxychloroquine The metabolism of Hydroxychloroquine can be decreased when combined with Trametinib. |
Meloxicam | Meloxicam Meloxicam may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Pantoprazole | Pantoprazole Pantoprazole may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Temozolomide | Temozolomide Temozolomide may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Zaleplon | Zaleplon Zaleplon may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Perindopril | Perindopril Perindopril may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Tenofovir | Tenofovir Tenofovir may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Choline Magnesium Trisalicylate | Choline Magnesium Trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Sirolimus | Sirolimus The metabolism of Sirolimus can be increased when combined with Trametinib. |
Eplerenone | Eplerenone Eplerenone may increase the excretion rate of Trametinib which could result in a lower serum level and potentially a reduction in efficacy. |
Zonisamide | Zonisamide Zonisamide may increase the excretion rate of Trametinib which could result in a lower serum level and potentially a reduction in efficacy. |
Aripiprazole | Aripiprazole The metabolism of Aripiprazole can be increased when combined with Trametinib. |
Atomoxetine | Atomoxetine Atomoxetine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Atazanavir | Atazanavir Atazanavir may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Almotriptan | Almotriptan The metabolism of Almotriptan can be decreased when combined with Trametinib. |
Rosuvastatin | Rosuvastatin The metabolism of Rosuvastatin can be increased when combined with Trametinib. |
Emtricitabine | Emtricitabine Emtricitabine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Memantine | Memantine Memantine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Tadalafil | Tadalafil Tadalafil may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Progesterone | Progesterone The metabolism of Progesterone can be increased when combined with Trametinib. |
Apomorphine Injection | Apomorphine Injection The metabolism of Apomorphine can be decreased when combined with Trametinib. |
Darbepoetin Alfa Injection | Darbepoetin Alfa Injection The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Trametinib. |
Duloxetine | Duloxetine The metabolism of Trametinib can be increased when combined with Duloxetine. |
Norethindrone | Norethindrone The metabolism of Norethisterone can be increased when combined with Trametinib. |
Tinidazole | Tinidazole Tinidazole may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Cefditoren | Cefditoren Cefdinir may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Cyanocobalamin Injection | Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Erlotinib | Erlotinib The serum concentration of Erlotinib can be decreased when it is combined with Trametinib. |
Eszopiclone | Eszopiclone The serum concentration of Eszopiclone can be decreased when it is combined with Trametinib. |
Ganciclovir | Ganciclovir Ganciclovir may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Ribavirin | Ribavirin Ribavirin may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Valganciclovir | Valganciclovir Valganciclovir may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Adefovir | Adefovir Adefovir may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Dextroamphetamine | Dextroamphetamine Amphetamine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Ramelteon | Ramelteon Ramelteon may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Fentanyl | Fentanyl Fentanyl may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Pregabalin | Pregabalin Pregabalin may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Ranolazine | Ranolazine The metabolism of Trametinib can be increased when combined with Ranolazine. |
Rasagiline | Rasagiline Rasagiline may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Imatinib | Imatinib The metabolism of Imatinib can be decreased when combined with Trametinib. |
Sitagliptin | Sitagliptin The metabolism of Sitagliptin can be decreased when combined with Trametinib. |
Varenicline | Varenicline Varenicline may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Albuterol | Albuterol Salbutamol may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Paliperidone | Paliperidone Paliperidone may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Bortezomib | Bortezomib The metabolism of Bortezomib can be increased when combined with Trametinib. |
Clofarabine Injection | Clofarabine Injection Clofarabine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Lubiprostone | Lubiprostone Lubiprostone may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Pemetrexed Injection | Pemetrexed Injection Trametinib may decrease the excretion rate of Pemetrexed which could result in a higher serum level. |
Retapamulin | Retapamulin The metabolism of Retapamulin can be increased when combined with Trametinib. |
Sorafenib | Sorafenib The metabolism of Sorafenib can be increased when combined with Trametinib. |
Sunitinib | Sunitinib The metabolism of Sunitinib can be increased when combined with Trametinib. |
Lapatinib | Lapatinib The metabolism of Lapatinib can be decreased when combined with Trametinib. |
Levocetirizine | Levocetirizine Levocetirizine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Pegaptanib Injection | Pegaptanib Injection Pegaptanib may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Dasatinib | Dasatinib The metabolism of Dasatinib can be increased when combined with Trametinib. |
Azacitidine Injection | Azacitidine Injection Azacitidine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Temsirolimus | Temsirolimus The metabolism of Temsirolimus can be increased when combined with Trametinib. |
Lenalidomide | Lenalidomide Lenalidomide may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Nilotinib | Nilotinib The metabolism of Nilotinib can be increased when combined with Trametinib. |
Budesonide | Budesonide Budesonide may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Desmopressin | Desmopressin Desmopressin may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Doripenem Injection | Doripenem Injection Doripenem may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Arsenic Trioxide Injection | Arsenic Trioxide Injection Arsenic trioxide may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Desvenlafaxine | Desvenlafaxine Desvenlafaxine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Cevimeline | Cevimeline Cevimeline may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Tretinoin | Tretinoin The metabolism of Tretinoin can be decreased when combined with Trametinib. |
Certolizumab Injection | Certolizumab Injection Certolizumab pegol may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Ixabepilone Injection | Ixabepilone Injection The metabolism of Ixabepilone can be increased when combined with Trametinib. |
Irinotecan Injection | Irinotecan Injection The metabolism of Irinotecan can be increased when combined with Trametinib. |
Daptomycin Injection | Daptomycin Injection Daptomycin may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Methylnaltrexone Injection | Methylnaltrexone Injection Methylnaltrexone may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Rufinamide | Rufinamide The metabolism of Rufinamide can be increased when combined with Trametinib. |
Midazolam | Midazolam Midazolam may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Dexrazoxane Injection | Dexrazoxane Injection Dexrazoxane may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Eltrombopag | Eltrombopag The metabolism of Eltrombopag can be decreased when combined with Trametinib. |
Milnacipran | Milnacipran The metabolism of Milnacipran can be increased when combined with Trametinib. |
Plerixafor Injection | Plerixafor Injection Plerixafor may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Fesoterodine | Fesoterodine Fesoterodine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Prasugrel | Prasugrel Prasugrel may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Lacosamide | Lacosamide The metabolism of Lacosamide can be increased when combined with Trametinib. |
Everolimus | Everolimus The metabolism of Everolimus can be increased when combined with Trametinib. |
Tolvaptan (low blood sodium) | Tolvaptan (low blood sodium) The metabolism of Trametinib can be increased when combined with Tolvaptan. |
Dronedarone | Dronedarone The metabolism of Dronedarone can be increased when combined with Trametinib. |
Pralatrexate Injection | Pralatrexate Injection Pralatrexate may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Palonosetron Injection | Palonosetron Injection Palonosetron may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Saxagliptin | Saxagliptin Saxagliptin may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Telavancin Injection | Telavancin Injection Telavancin may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Romidepsin Injection | Romidepsin Injection The metabolism of Romidepsin can be increased when combined with Trametinib. |
Topotecan | Topotecan Topotecan may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Pazopanib | Pazopanib The metabolism of Pazopanib can be increased when combined with Trametinib. |
Pitavastatin | Pitavastatin The metabolism of Pitavastatin can be decreased when combined with Trametinib. |
Albendazole | Albendazole The metabolism of Albendazole can be increased when combined with Trametinib. |
Ulipristal | Ulipristal The metabolism of Ulipristal can be increased when combined with Trametinib. |
Levonorgestrel | Levonorgestrel The metabolism of Levonorgestrel can be increased when combined with Trametinib. |
Dalfampridine | Dalfampridine Dalfampridine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Cabazitaxel Injection | Cabazitaxel Injection The metabolism of Cabazitaxel can be increased when combined with Trametinib. |
Ceftaroline Injection | Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Acetaminophen Injection | Acetaminophen Injection Acetaminophen may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Ipilimumab Injection | Ipilimumab Injection Ipilimumab may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Denileukin Diftitox Injection | Denileukin Diftitox Injection Aldesleukin may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Terbutaline Injection | Terbutaline Injection Terbutaline may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Busulfan Injection | Busulfan Injection The metabolism of Busulfan can be increased when combined with Trametinib. |
Roflumilast | Roflumilast The metabolism of Trametinib can be increased when combined with Roflumilast. |
Linagliptin | Linagliptin The metabolism of Linagliptin can be increased when combined with Trametinib. |
Cyclophosphamide Injection | Cyclophosphamide Injection The metabolism of Cyclophosphamide can be increased when combined with Trametinib. |
Rivaroxaban | Rivaroxaban Rivaroxaban may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Brentuximab Vedotin Injection | Brentuximab Vedotin Injection The metabolism of Brentuximab vedotin can be increased when combined with Trametinib. |
Ruxolitinib | Ruxolitinib The metabolism of Trametinib can be increased when combined with Ruxolitinib. |
Vandetanib | Vandetanib The metabolism of Vandetanib can be increased when combined with Trametinib. |
Clobazam | Clobazam Clobazam may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Vemurafenib | Vemurafenib The metabolism of Vemurafenib can be increased when combined with Trametinib. |
Deferiprone | Deferiprone Deferiprone may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Axitinib | Axitinib The metabolism of Axitinib can be increased when combined with Trametinib. |
Crizotinib | Crizotinib The metabolism of Crizotinib can be increased when combined with Trametinib. |
Cabergoline | Cabergoline The metabolism of Cabergoline can be increased when combined with Trametinib. |
Naloxone Injection | Naloxone Injection Naloxone may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Fondaparinux Injection | Fondaparinux Injection Fondaparinux may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Enzalutamide | Enzalutamide The serum concentration of Enzalutamide can be increased when it is combined with Trametinib. |
Mirabegron | Mirabegron Mirabegron may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Regorafenib | Regorafenib The metabolism of Regorafenib can be increased when combined with Trametinib. |
Bosutinib | Bosutinib The metabolism of Bosutinib can be increased when combined with Trametinib. |
Teduglutide Injection | Teduglutide Injection Teduglutide may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Alogliptin | Alogliptin Alogliptin may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Ponatinib | Ponatinib The metabolism of Ponatinib can be increased when combined with Trametinib. |
Pomalidomide | Pomalidomide The metabolism of Trametinib can be increased when combined with Pomalidomide. |
Ado-trastuzumab Emtansine Injection | Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be increased when combined with Trametinib. |
Apixaban | Apixaban The metabolism of Apixaban can be decreased when combined with Trametinib. |
Canagliflozin | Canagliflozin Canagliflozin may increase the excretion rate of Trametinib which could result in a lower serum level and potentially a reduction in efficacy. |
Methazolamide | Methazolamide Methazolamide may increase the excretion rate of Trametinib which could result in a lower serum level and potentially a reduction in efficacy. |
Dabrafenib | Dabrafenib The risk or severity of adverse effects can be increased when Trametinib is combined with Dabrafenib. |
Levomilnacipran | Levomilnacipran The metabolism of Levomilnacipran can be increased when combined with Trametinib. |
Ertapenem Injection | Ertapenem Injection Ertapenem may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Vortioxetine | Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Trametinib. |
Perampanel | Perampanel The metabolism of Perampanel can be increased when combined with Trametinib. |
Lomitapide | Lomitapide The metabolism of Lomitapide can be increased when combined with Trametinib. |
Ketorolac Injection | Ketorolac Injection The metabolism of Trametinib can be decreased when combined with Ketorolac. |
Sofosbuvir | Sofosbuvir Trametinib may decrease the excretion rate of Sofosbuvir which could result in a higher serum level. |
Dapagliflozin | Dapagliflozin Dapagliflozin may increase the excretion rate of Trametinib which could result in a lower serum level and potentially a reduction in efficacy. |
Apremilast | Apremilast Apremilast may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Droxidopa | Droxidopa Droxidopa may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Ceritinib | Ceritinib The metabolism of Ceritinib can be increased when combined with Trametinib. |
Idelalisib | Idelalisib The metabolism of Idelalisib can be increased when combined with Trametinib. |
Testosterone Injection | Testosterone Injection Testosterone may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Vorapaxar | Vorapaxar The metabolism of Vorapaxar can be increased when combined with Trametinib. |
Suvorexant | Suvorexant The metabolism of Suvorexant can be increased when combined with Trametinib. |
Edoxaban | Edoxaban Trametinib may decrease the excretion rate of Edoxaban which could result in a higher serum level. |
Olaparib | Olaparib The metabolism of Olaparib can be increased when combined with Trametinib. |
Methamphetamine | Methamphetamine Metamfetamine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Tasimelteon | Tasimelteon The metabolism of Tasimelteon can be increased when combined with Trametinib. |
Riociguat | Riociguat The metabolism of Riociguat can be decreased when combined with Trametinib. |
Nintedanib | Nintedanib The metabolism of Nintedanib can be increased when combined with Trametinib. |
Palbociclib | Palbociclib The metabolism of Palbociclib can be increased when combined with Trametinib. |
Panobinostat | Panobinostat The metabolism of Panobinostat can be increased when combined with Trametinib. |
Haloperidol Injection | Haloperidol Injection Haloperidol may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Amiloride | Amiloride Amiloride may increase the excretion rate of Trametinib which could result in a lower serum level and potentially a reduction in efficacy. |
Macitentan | Macitentan Trametinib may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Sonidegib | Sonidegib The metabolism of Sonidegib can be increased when combined with Trametinib. |
Ziprasidone Injection | Ziprasidone Injection The metabolism of Ziprasidone can be increased when combined with Trametinib. |
Penicillin G Procaine Injection | Penicillin G Procaine Injection Trametinib may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level. |
Cobimetinib | Cobimetinib The metabolism of Cobimetinib can be increased when combined with Trametinib. |
Trabectedin Injection | Trabectedin Injection The metabolism of Trabectedin can be increased when combined with Trametinib. |
Osimertinib | Osimertinib The metabolism of Osimertinib can be increased when combined with Trametinib. |
Alectinib | Alectinib The metabolism of Alectinib can be increased when combined with Trametinib. |
Ixazomib | Ixazomib The metabolism of Ixazomib can be increased when combined with Trametinib. |
Lesinurad | Lesinurad Trametinib may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
Amphotericin B Liposomal Injection | Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Brivaracetam Injection | Brivaracetam Injection Brivaracetam may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Venetoclax | Venetoclax The metabolism of Venetoclax can be increased when combined with Trametinib. |
Selexipag | Selexipag The metabolism of Selexipag can be decreased when combined with Trametinib. |
Furosemide Injection | Furosemide Injection Furosemide may increase the excretion rate of Trametinib which could result in a lower serum level and potentially a reduction in efficacy. |
Lixisenatide Injection | Lixisenatide Injection Trametinib may decrease the excretion rate of Lixisenatide which could result in a higher serum level. |
Ribociclib | Ribociclib The metabolism of Ribociclib can be increased when combined with Trametinib. |
Brigatinib | Brigatinib The metabolism of Brigatinib can be increased when combined with Trametinib. |
Doxepin (Insomnia) | Doxepin (Insomnia) Doxepin may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Deutetrabenazine | Deutetrabenazine Trametinib may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level. |
Valbenazine | Valbenazine Trametinib may decrease the excretion rate of Valbenazine which could result in a higher serum level. |
Naldemedine | Naldemedine Trametinib may decrease the excretion rate of Naldemedine which could result in a higher serum level. |
Midostaurin | Midostaurin The metabolism of Midostaurin can be increased when combined with Trametinib. |
Neratinib | Neratinib The metabolism of Neratinib can be increased when combined with Trametinib. |
Enasidenib | Enasidenib The metabolism of Enasidenib can be increased when combined with Trametinib. |
Aprepitant/Fosaprepitant Injection | Aprepitant/Fosaprepitant Injection The metabolism of Fosaprepitant can be increased when combined with Trametinib. |
Benznidazole | Benznidazole Trametinib may decrease the excretion rate of Benznidazole which could result in a higher serum level. |
Copanlisib Injection | Copanlisib Injection The metabolism of Copanlisib can be increased when combined with Trametinib. |
Delafloxacin | Delafloxacin Trametinib may decrease the excretion rate of Delafloxacin which could result in a higher serum level. |
Abemaciclib | Abemaciclib The metabolism of Abemaciclib can be increased when combined with Trametinib. |
Acalabrutinib | Acalabrutinib The metabolism of Acalabrutinib can be increased when combined with Trametinib. |
Ertugliflozin | Ertugliflozin Ertugliflozin may increase the excretion rate of Trametinib which could result in a lower serum level and potentially a reduction in efficacy. |
Buprenorphine Injection | Buprenorphine Injection The metabolism of Buprenorphine can be decreased when combined with Trametinib. |
Apalutamide | Apalutamide The serum concentration of Apalutamide can be increased when it is combined with Trametinib. |
Baricitinib | Baricitinib The metabolism of Baricitinib can be increased when combined with Trametinib. |
Lofexidine | Lofexidine Lofexidine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Plazomicin Injection | Plazomicin Injection Trametinib may decrease the excretion rate of Plazomicin which could result in a higher serum level. |
Ivosidenib | Ivosidenib The metabolism of Ivosidenib can be increased when combined with Trametinib. |
Elagolix | Elagolix The metabolism of Elagolix can be decreased when combined with Trametinib. |
Dacomitinib | Dacomitinib The metabolism of Dacomitinib can be increased when combined with Trametinib. |
Duvelisib | Duvelisib The metabolism of Duvelisib can be increased when combined with Trametinib. |
Stiripentol | Stiripentol Trametinib may decrease the excretion rate of Stiripentol which could result in a higher serum level. |
Gilteritinib | Gilteritinib The metabolism of Gilteritinib can be increased when combined with Trametinib. |
Glasdegib | Glasdegib The metabolism of Glasdegib can be decreased when combined with Trametinib. |
Lorlatinib | Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Trametinib. |
Methoxy Polyethylene Glycol-Epoetin Beta Injection | Methoxy Polyethylene Glycol-Epoetin Beta Injection The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Trametinib. |
Paclitaxel (with albumin) Injection | Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be increased when combined with Trametinib. |
Prucalopride | Prucalopride The metabolism of Trametinib can be increased when combined with Prucalopride. |
Siponimod | Siponimod The metabolism of Siponimod can be increased when combined with Trametinib. |
Acyclovir Ophthalmic | Acyclovir Ophthalmic Acyclovir may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Erdafitinib | Erdafitinib The metabolism of Erdafitinib can be increased when combined with Trametinib. |
Alpelisib | Alpelisib The metabolism of Alpelisib can be increased when combined with Trametinib. |
Solriamfetol | Solriamfetol Trametinib may decrease the excretion rate of Solriamfetol which could result in a higher serum level. |
Entrectinib | Entrectinib The metabolism of Entrectinib can be increased when combined with Trametinib. |
Pexidartinib | Pexidartinib The metabolism of Pexidartinib can be increased when combined with Trametinib. |
Istradefylline | Istradefylline The metabolism of Istradefylline can be decreased when combined with Trametinib. |
Pitolisant | Pitolisant Trametinib may decrease the excretion rate of Pitolisant which could result in a higher serum level. |
Lefamulin | Lefamulin The metabolism of Lefamulin can be increased when combined with Trametinib. |
Phenytoin Injection | Phenytoin Injection The metabolism of Phenytoin can be decreased when combined with Trametinib. |
Fosphenytoin Injection | Fosphenytoin Injection The metabolism of Fosphenytoin can be increased when combined with Trametinib. |
Zanubrutinib | Zanubrutinib The metabolism of Zanubrutinib can be increased when combined with Trametinib. |
Lumateperone | Lumateperone The serum concentration of Lumateperone can be decreased when it is combined with Trametinib. |
Tazemetostat | Tazemetostat The metabolism of Tazemetostat can be increased when combined with Trametinib. |
Ozanimod | Ozanimod The metabolism of Ozanimod can be decreased when combined with Trametinib. |
Selumetinib | Selumetinib The metabolism of Selumetinib can be decreased when combined with Trametinib. |
Rimegepant | Rimegepant The metabolism of Rimegepant can be increased when combined with Trametinib. |
Tucatinib | Tucatinib The metabolism of Tucatinib can be decreased when combined with Trametinib. |
Selpercatinib | Selpercatinib The serum concentration of Selpercatinib can be decreased when it is combined with Trametinib. |
Capmatinib | Capmatinib The serum concentration of Capmatinib can be decreased when it is combined with Trametinib. |
Lemborexant | Lemborexant The serum concentration of Lemborexant can be decreased when it is combined with Trametinib. |
Progestin-Only (drospirenone) Oral Contraceptives | Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Drospirenone can be increased when combined with Trametinib. |
Viloxazine | Viloxazine Trametinib may decrease the excretion rate of Viloxazine which could result in a higher serum level. |
Tobramycin Injection | Tobramycin Injection Tobramycin may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Theophylline | Theophylline The metabolism of Theophylline can be increased when combined with Trametinib. |
Fenoprofen | Fenoprofen Fenoprofen may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Indomethacin | Indomethacin Indomethacin may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Mefenamic Acid | Mefenamic Acid Mefenamic acid may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Naproxen | Naproxen The metabolism of Naproxen can be decreased when combined with Trametinib. |
Tolmetin | Tolmetin Tolmetin may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Sulindac | Sulindac Sulindac may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Isotretinoin | Isotretinoin Isotretinoin may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Sucralfate | Sucralfate Sucralfate may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Floxuridine | Floxuridine Floxuridine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Metaxalone | Metaxalone Metaxalone may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Methotrexate Injection | Methotrexate Injection The metabolism of Trametinib can be increased when combined with Methotrexate. |
Chlorpromazine | Chlorpromazine The metabolism of Trametinib can be increased when combined with Chlorpromazine. |
Diazepam | Diazepam Diazepam may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Oxazepam | Oxazepam Oxazepam may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Flurazepam | Flurazepam Flurazepam may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Clorazepate | Clorazepate Clorazepic acid may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Lorazepam | Lorazepam The metabolism of Trametinib can be increased when combined with Lorazepam. |
Carmustine | Carmustine Carmustine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Amantadine | Amantadine Amantadine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Codeine | Codeine Codeine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Phenelzine | Phenelzine Phenelzine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Tetracycline | Tetracycline Tetracycline may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Prochlorperazine | Prochlorperazine The metabolism of Prochlorperazine can be increased when combined with Trametinib. |
Bleomycin | Bleomycin Bleomycin may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Dapsone | Dapsone The metabolism of Dapsone can be decreased when combined with Trametinib. |
Sulfadiazine | Sulfadiazine The metabolism of Sulfadiazine can be decreased when combined with Trametinib. |
Methadone | Methadone The metabolism of Methadone can be decreased when combined with Trametinib. |
Benztropine | Benztropine Benzatropine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Maprotiline | Maprotiline Maprotiline may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Ibuprofen | Ibuprofen The metabolism of Ibuprofen can be decreased when combined with Trametinib. |
Azathioprine | Azathioprine Azathioprine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Phentermine | Phentermine The metabolism of Phentermine can be increased when combined with Trametinib. |
Methylphenidate | Methylphenidate Methylphenidate may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Sulfasalazine | Sulfasalazine Sulfasalazine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Doxorubicin | Doxorubicin The metabolism of Doxorubicin can be increased when combined with Trametinib. |
Phenazopyridine | Phenazopyridine Phenazopyridine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Carbamazepine | Carbamazepine The metabolism of Carbamazepine can be increased when combined with Trametinib. |
Methyldopa | Methyldopa Methyldopa may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Clonidine | Clonidine The metabolism of Clonidine can be increased when combined with Trametinib. |
Hydralazine | Hydralazine Hydralazine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Cimetidine | Cimetidine Cimetidine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Gentamicin Injection | Gentamicin Injection Gentamicin may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Warfarin | Warfarin The metabolism of Warfarin can be increased when combined with Trametinib. |
Clonazepam | Clonazepam The metabolism of Clonazepam can be increased when combined with Trametinib. |
Loperamide | Loperamide The metabolism of Loperamide can be decreased when combined with Trametinib. |
Promethazine | Promethazine Promethazine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Meclofenamate | Meclofenamate Meclofenamic acid may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Nitrofurantoin | Nitrofurantoin Nitrofurantoin may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Digoxin | Digoxin Trametinib may decrease the excretion rate of Digoxin which could result in a higher serum level. |
Chloroquine | Chloroquine The metabolism of Chloroquine can be decreased when combined with Trametinib. |
Quinine | Quinine The metabolism of Quinine can be decreased when combined with Trametinib. |
Triamterene | Triamterene Triamterene may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Chlorothiazide | Chlorothiazide Chlorothiazide may increase the excretion rate of Trametinib which could result in a lower serum level and potentially a reduction in efficacy. |
Chlorthalidone | Chlorthalidone Chlorthalidone may increase the excretion rate of Trametinib which could result in a lower serum level and potentially a reduction in efficacy. |
Metolazone | Metolazone Metolazone may increase the excretion rate of Trametinib which could result in a lower serum level and potentially a reduction in efficacy. |
Isosorbide | Isosorbide The metabolism of Isosorbide can be increased when combined with Trametinib. |
Clindamycin Injection | Clindamycin Injection The metabolism of Clindamycin can be increased when combined with Trametinib. |
Secobarbital | Secobarbital Secobarbital may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Desipramine | Desipramine Desipramine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Amitriptyline | Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Trametinib. |
Imipramine | Imipramine Imipramine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Probenecid | Probenecid Probenecid may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Quinidine | Quinidine The metabolism of Quinidine can be increased when combined with Trametinib. |
Procainamide | Procainamide Trametinib may decrease the excretion rate of Procainamide which could result in a higher serum level. |
Isoniazid | Isoniazid Isoniazid may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Pyrazinamide | Pyrazinamide Pyrazinamide may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Disopyramide | Disopyramide Disopyramide may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Tamoxifen | Tamoxifen The metabolism of Tamoxifen can be increased when combined with Trametinib. |
Butabarbital | Butabarbital Butabarbital may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Liothyronine | Liothyronine Liothyronine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Methimazole | Methimazole Methimazole may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Chlorpropamide | Chlorpropamide Chlorpropamide may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Tolbutamide | Tolbutamide The metabolism of Tolbutamide can be decreased when combined with Trametinib. |
Tolazamide | Tolazamide Tolazamide may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Baclofen | Baclofen Baclofen may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Ethambutol | Ethambutol Ethambutol may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Methyclothiazide | Methyclothiazide Methyclothiazide may increase the excretion rate of Trametinib which could result in a lower serum level and potentially a reduction in efficacy. |
Hydrochlorothiazide | Hydrochlorothiazide Hydrochlorothiazide may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Chlorzoxazone | Chlorzoxazone Chlorzoxazone may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Pyridoxine | Pyridoxine Pyridoxine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Folic Acid | Folic Acid Folic acid may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Propranolol (Cardiovascular) | Propranolol (Cardiovascular) Propranolol may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Nortriptyline | Nortriptyline The metabolism of Nortriptyline can be increased when combined with Trametinib. |
Spironolactone | Spironolactone Spironolactone may increase the excretion rate of Trametinib which could result in a lower serum level and potentially a reduction in efficacy. |
Amphotericin B Injection | Amphotericin B Injection Amphotericin B may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Phytonadione | Phytonadione Phylloquinone may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Amikacin Injection | Amikacin Injection Amikacin may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Nadolol | Nadolol Nadolol may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Allopurinol | Allopurinol Allopurinol may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Flavoxate | Flavoxate Flavoxate may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Fluorouracil Injection | Fluorouracil Injection The metabolism of Fluorouracil can be decreased when combined with Trametinib. |
Colchicine | Colchicine Colchicine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Cefaclor | Cefaclor Cefaclor may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Cefadroxil | Cefadroxil Cefadroxil may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Cefazolin Injection | Cefazolin Injection Cefazolin may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Cephalexin | Cephalexin Cephalexin may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Cefoxitin Injection | Cefoxitin Injection Cefoxitin may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Dacarbazine | Dacarbazine Dacarbazine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Acetazolamide | Acetazolamide Acetazolamide may increase the excretion rate of Trametinib which could result in a lower serum level and potentially a reduction in efficacy. |
Cefotaxime Injection | Cefotaxime Injection Cefotaxime may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Calcitonin Salmon Injection | Calcitonin Salmon Injection Salmon calcitonin may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Pyrantel | Pyrantel Trametinib may decrease the excretion rate of Pyrantel which could result in a higher serum level. |
Thiotepa Injection | Thiotepa Injection The metabolism of Thiotepa can be increased when combined with Trametinib. |
Vincristine Injection | Vincristine Injection The metabolism of Vincristine can be increased when combined with Trametinib. |
Vinblastine | Vinblastine The metabolism of Vinblastine can be increased when combined with Trametinib. |
Ethacrynic Acid | Ethacrynic Acid Etacrynic acid may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Colistimethate Injection | Colistimethate Injection Colistimethate may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Metoprolol | Metoprolol The metabolism of Trametinib can be increased when combined with Metoprolol. |
Aspirin | Aspirin Acetylsalicylic acid may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Salsalate | Salsalate Salsalate may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Alprazolam | Alprazolam Alprazolam may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Temazepam | Temazepam Temazepam may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Triazolam | Triazolam Triazolam may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Dicyclomine | Dicyclomine Dicyclomine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Propantheline | Propantheline Propantheline may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Trimethoprim | Trimethoprim Trimethoprim may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Diltiazem | Diltiazem The metabolism of Diltiazem can be decreased when combined with Trametinib. |
Nifedipine | Nifedipine Nifedipine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Timolol | Timolol Timolol may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Verapamil | Verapamil The metabolism of Verapamil can be decreased when combined with Trametinib. |
Pindolol | Pindolol Pindolol may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Cisplatin Injection | Cisplatin Injection Trametinib may decrease the excretion rate of Cisplatin which could result in a higher serum level. |
Diflunisal | Diflunisal Diflunisal may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Piroxicam | Piroxicam The metabolism of Piroxicam can be decreased when combined with Trametinib. |
Bumetanide | Bumetanide Bumetanide may increase the excretion rate of Trametinib which could result in a lower serum level and potentially a reduction in efficacy. |
Etoposide | Etoposide The metabolism of Etoposide can be increased when combined with Trametinib. |
Glipizide | Glipizide Glipizide may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Indapamide | Indapamide Indapamide may increase the excretion rate of Trametinib which could result in a lower serum level and potentially a reduction in efficacy. |
Amoxicillin | Amoxicillin Amoxicillin may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Oxacillin Injection | Oxacillin Injection Oxacillin may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Pentoxifylline | Pentoxifylline Pentoxifylline may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Pentamidine Injection | Pentamidine Injection Pentamidine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Ceftriaxone Injection | Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Labetalol | Labetalol Labetalol may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Auranofin | Auranofin Auranofin may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Leuprolide Injection | Leuprolide Injection Leuprolide may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Gemfibrozil | Gemfibrozil Gemfibrozil may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Dipivefrin Ophthalmic | Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Ceftazidime Injection | Ceftazidime Injection Ceftazidime may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Ketoprofen | Ketoprofen Ketoprofen may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Cefotetan Injection | Cefotetan Injection Cefotetan may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Pimozide | Pimozide The metabolism of Pimozide can be increased when combined with Trametinib. |
Flurbiprofen | Flurbiprofen Flurbiprofen may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Amiodarone | Amiodarone The metabolism of Amiodarone can be increased when combined with Trametinib. |
Aztreonam Injection | Aztreonam Injection Aztreonam may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Buspirone | Buspirone Buspirone may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Lovastatin | Lovastatin The metabolism of Lovastatin can be decreased when combined with Trametinib. |
Ciprofloxacin | Ciprofloxacin Ciprofloxacin may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Mesalamine | Mesalamine Mesalazine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Diclofenac | Diclofenac The metabolism of Diclofenac can be decreased when combined with Trametinib. |
Clozapine | Clozapine Clozapine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Estazolam | Estazolam Estazolam may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Didanosine | Didanosine Didanosine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Pentostatin Injection | Pentostatin Injection Pentostatin may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Etodolac | Etodolac Etodolac may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Fosinopril | Fosinopril Fosinopril may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Nabumetone | Nabumetone Nabumetone may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Simvastatin | Simvastatin The metabolism of Simvastatin can be decreased when combined with Trametinib. |
Epoetin Alfa, Injection | Epoetin Alfa, Injection The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Trametinib. |
Amlodipine | Amlodipine The metabolism of Amlodipine can be increased when combined with Trametinib. |
Teniposide Injection | Teniposide Injection The metabolism of Teniposide can be increased when combined with Trametinib. |
Lisinopril | Lisinopril Lisinopril may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Oxaprozin | Oxaprozin Oxaprozin may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Bisoprolol | Bisoprolol Bisoprolol may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Zolpidem | Zolpidem The metabolism of Zolpidem can be increased when combined with Trametinib. |
Doxazosin | Doxazosin The metabolism of Doxazosin can be increased when combined with Trametinib. |
Isradipine | Isradipine Isradipine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Omeprazole | Omeprazole The metabolism of Omeprazole can be decreased when combined with Trametinib. |
Cisapride | Cisapride The metabolism of Cisapride can be decreased when combined with Trametinib. |
Fluvastatin | Fluvastatin The metabolism of Fluvastatin can be decreased when combined with Trametinib. |
Venlafaxine | Venlafaxine Venlafaxine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Famciclovir | Famciclovir The metabolism of Famciclovir can be increased when combined with Trametinib. |
Fluvoxamine | Fluvoxamine Fluvoxamine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Nefazodone | Nefazodone Nefazodone may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Lamotrigine | Lamotrigine Lamotrigine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Valacyclovir | Valacyclovir Valaciclovir may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Tramadol | Tramadol The metabolism of Trametinib can be increased when combined with Tramadol. |
Vinorelbine Injection | Vinorelbine Injection The metabolism of Vinorelbine can be increased when combined with Trametinib. |
Carboplatin Injection | Carboplatin Injection Carboplatin may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Lansoprazole | Lansoprazole The metabolism of Lansoprazole can be decreased when combined with Trametinib. |
Ifosfamide Injection | Ifosfamide Injection The metabolism of Ifosfamide can be increased when combined with Trametinib. |
Nicardipine | Nicardipine The metabolism of Nicardipine can be decreased when combined with Trametinib. |
Bupropion | Bupropion Bupropion may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Ticlopidine | Ticlopidine The metabolism of Trametinib can be increased when combined with Ticlopidine. |
Metformin | Metformin Metformin may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Nisoldipine | Nisoldipine Nisoldipine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Lamivudine | Lamivudine Lamivudine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Acarbose | Acarbose Acarbose may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Anastrozole | Anastrozole The metabolism of Anastrozole can be decreased when combined with Trametinib. |
Gemcitabine Injection | Gemcitabine Injection Gemcitabine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Docetaxel Injection | Docetaxel Injection The metabolism of Docetaxel can be increased when combined with Trametinib. |
Cidofovir Injection | Cidofovir Injection Cidofovir may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Meropenem Injection | Meropenem Injection Meropenem may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Clomipramine | Clomipramine The metabolism of Trametinib can be increased when combined with Clomipramine. |
Zafirlukast | Zafirlukast The metabolism of Zafirlukast can be decreased when combined with Trametinib. |
Fosfomycin | Fosfomycin Fosfomycin may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Topiramate | Topiramate Topiramate may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Pramipexole | Pramipexole Pramipexole may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Azithromycin | Azithromycin The metabolism of Azithromycin can be increased when combined with Trametinib. |
Nilutamide | Nilutamide Nilutamide may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Flutamide | Flutamide Flutamide may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Selegiline | Selegiline The metabolism of Selegiline can be decreased when combined with Trametinib. |
Bicalutamide | Bicalutamide The metabolism of Bicalutamide can be increased when combined with Trametinib. |
Irbesartan | Irbesartan The metabolism of Irbesartan can be decreased when combined with Trametinib. |
Tamsulosin | Tamsulosin Tamsulosin may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Quetiapine | Quetiapine Quetiapine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Cefepime Injection | Cefepime Injection Cefepime may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Cefprozil | Cefprozil Cefprozil may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Cefpodoxime | Cefpodoxime Cefpodoxime may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Cetirizine | Cetirizine Cetirizine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Tolcapone | Tolcapone Tolcapone may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Capecitabine | Capecitabine Capecitabine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Abacavir | Abacavir Abacavir may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Pioglitazone | Pioglitazone The serum concentration of Pioglitazone can be increased when it is combined with Trametinib. |
Celecoxib | Celecoxib The metabolism of Celecoxib can be decreased when combined with Trametinib. |
Rosiglitazone | Rosiglitazone The metabolism of Rosiglitazone can be decreased when combined with Trametinib. |
Tolterodine | Tolterodine Tolterodine may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Oseltamivir | Oseltamivir Oseltamivir may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Balsalazide | Balsalazide Balsalazide may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Nateglinide | Nateglinide Nateglinide may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Rabeprazole | Rabeprazole Rabeprazole may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Terbinafine | Terbinafine The metabolism of Terbinafine can be decreased when combined with Trametinib. |
Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists