Drug & supplement interaction

Humann Superbeets Heart Chews + Codeine, Paracetamol

Codeine, Paracetamol brand name: Co-codamol.

Minor Interaction
Medically reviewed by · Updated November 2023
The bottom line Minor

Codeine, Paracetamol falls into 3 drug categories that Humann Superbeets Heart Chews can interact with; the most serious is rated minor. Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Read the full interaction report
SeverityMinor
LikelihoodUnlikely
Interactions3
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Humann Superbeets Heart Chews and Codeine, Paracetamol

These two interact in 3 distinct ways. Each one is explained separately below.

Why Are There 3 Interactions?

Humann Superbeets Heart Chews interacts with whole categories of medication. Codeine, Paracetamol falls into 3 of those categories, so it can interact with Humann Superbeets Heart Chews in 3 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Minor).

Minor

Cytochrome P450 2D6 (Cyp2D6) Substrates

1 of 3

Why this applies to Codeine, Paracetamol

Codeine, Paracetamol falls under Cytochrome P450 2D6 (Cyp2D6) Substrates — the group Humann Superbeets Heart Chews interacts with.

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews). Laboratory studies suggest that grape seed extract might have inhibitory effects on the CYP2D6 metabolizing enzyme. If this enzyme is inhibited, drugs metabolized by it may undergo slower metabolism, potentially leading to (in many cases) higher-than-normal drug levels. Elevated drug levels can increase the risk of experiencing side effects. However, it's crucial to highlight that, as of now, there is no documented or reported instance of this specific interaction occurring in human studies.
Severity Minor Likelihood Unlikely Evidence D

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's a twist worth knowing: the codeine in your co-codamol is actually a prodrug. Your body uses an enzyme called CYP2D6 to turn codeine into morphine, which is what gives you the pain relief. The grape seed extract in SuperBeets Heart Chews may gently slow that same enzyme down, at least in lab studies.

So if anything, this would tend to give you less pain relief from the codeine part, not more, since less of it gets converted to morphine. Honestly though, this is very weak, lab-only evidence with no real-world cases reported, and the paracetamol part isn't affected. I wouldn't lose sleep over it. If your pain isn't well controlled, just mention it to your pharmacist or doctor.

Contact Dr. Brian directly if you have additional questions on this interaction
Minor

Cytochrome P450 2E1 (Cyp2E1) Substrates

2 of 3

Codeine, Paracetamol also falls under Cytochrome P450 2E1 (Cyp2E1) Substrates.

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews). Laboratory studies suggest that grape seed extract might have inhibitory effects on the CYP2E1 metabolizing enzyme. If this enzyme is inhibited, drugs metabolized by it may undergo slower metabolism, potentially leading to (in many cases) higher-than-normal drug levels. Elevated drug levels can increase the risk of experiencing side effects. However, it's important to point out that there is no documented or reported instance of this specific interaction occurring in human studies.
Severity Minor Likelihood Unlikely Evidence D

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the situation with co-codamol (codeine plus paracetamol) and the SuperBeets Heart Chews. The chews contain grape seed extract, and lab studies hint it might slightly slow down an enzyme called CYP2E1. The paracetamol part of your medicine partly runs through this pathway. If anything, blocking CYP2E1 could nudge paracetamol breakdown along a safer route, but honestly the effect here is tiny and only seen in test tubes, never in real people.

The bottom line: this is a minor, unlikely interaction with weak evidence. I wouldn't lose sleep over it. Just keep your total paracetamol within safe daily limits and don't combine multiple products that contain it. If you have questions or take this regularly, have a quick chat with your pharmacist.

Contact Dr. Brian directly if you have additional questions on this interaction
Minor

Cytochrome P450 2E1 (Cyp2E1) Substrates

3 of 3

Codeine, Paracetamol also falls under Cytochrome P450 2E1 (Cyp2E1) Substrates.

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews). Laboratory studies suggest that grape seed extract might have inhibitory effects on the CYP2E1 metabolizing enzyme. If this enzyme is inhibited, drugs metabolized by it may undergo slower metabolism, potentially leading to (in many cases) higher-than-normal drug levels. Elevated drug levels can increase the risk of experiencing side effects. However, it's important to point out that there is no documented or reported instance of this specific interaction occurring in human studies.
Severity Minor Likelihood Unlikely Evidence D

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist with co-codamol (codeine plus paracetamol). The concern on file is that grape seed extract in these chews might slow down a liver enzyme called CYP2E1. That enzyme plays a role mainly in how paracetamol is broken down. If it were nudged a bit, the worry is slightly higher paracetamol levels in your system.

But honestly, I wouldn't lose sleep over this one. The evidence is only from lab studies, with no real-world cases in people, and it's rated minor and unlikely. The codeine side of this medicine isn't really driven by CYP2E1, so I don't expect more drowsiness or constipation from this combo. Still, never take extra paracetamol from other products, and check with your pharmacist if you take it daily.

Contact Dr. Brian directly if you have additional questions on this interaction

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Humann Superbeets Heart Chews Also Interacts With Other Medications

Humann Superbeets Heart Chews has 893 minor known drug interactions in our database — the Codeine, Paracetamol one above is among them. If you take anything else, check it against the full list below.

Minor 893 No known interaction 1,937 (incl. Codeine, Paracetamol)
Taking anything else?

Check Another of Your Medications Against Humann Superbeets Heart Chews

Covers the 2,830 medications we’ve checked against Humann Superbeets Heart Chews. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Codeine, Paracetamol

This page covers Humann Superbeets Heart Chews only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Codeine, Paracetamol page lists 240 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Gamma-hydroxybutyrate (ghb) (major).

By severity: 9 major · 191 moderate · 40 minor.

From our pharmacist’s overview on the Codeine, Paracetamol page

“Co-codamol pairs codeine, an opioid that slows breathing, with paracetamol, which can strain the liver, so I read its supplement list warily. Nine of the 240 ingredients on file carry a major rating, and most of those pile extra sedation onto the codeine.”

Reviewed by 2 · Jul 18, 2026

Open the Codeine, Paracetamol interaction page

How much people look this up

Where Humann Superbeets Heart Chews and Codeine, Paracetamol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Humann Superbeets Heart Chews
Top half

#665 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Codeine, Paracetamol
Top half

#1,171 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Humann Superbeets Heart Chews

What is Humann Superbeets Heart Chews?

Humann Superbeets Heart Chews
  • Heart and cardiovascular support
  • Healthy blood pressure support
  • Nitric oxide and blood flow support
  • Antioxidant support
  • Energy and circulation

SuperBeets Heart Chews are a beetroot- and grape-seed-based supplement marketed to support healthy blood flow, blood pressure, and nitric oxide production. Some research on dietary nitrate from beets and on grape seed extract suggests modest cardiovascular benefits, but evidence for this specific product is limited. It is generally well tolerated, but talk with your pharmacist or doctor before using it, especially if you have heart problems or take blood pressure medicine.

Read the full Humann Superbeets Heart Chews monograph & all interactions
Keep checking

Other Drugs & Humann Superbeets Heart Chews

Browse every other medication we’ve checked against Humann Superbeets Heart Chews — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
893Minor
1,936No known interaction
893 Minor 1,936 No interaction
Minor

893 interactions

Showing 60 of 893 minor interactions — see all 893 on the Humann Superbeets Heart Chews page.

No interaction 1,936 drugs checked — show the list

We also checked Humann Superbeets Heart Chews against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,936 medications checked with no known interaction — see the full Humann Superbeets Heart Chews list.

See the full Humann Superbeets Heart Chews interactions page
See every supplement checked against Codeine, Paracetamol, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Humann Superbeets Heart Chews monograph › Uses, safety, and every drug interaction in one place Codeine, Paracetamol supplement interactions › Every supplement checked against Codeine, Paracetamol, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Humann Superbeets Heart Chews and Codeine, Paracetamol Together: Common Questions

Can you take Humann Superbeets Heart Chews with Codeine, Paracetamol?
There is only a minor interaction, which is usually not serious. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 3 interactions listed for Humann Superbeets Heart Chews and Codeine, Paracetamol?
Codeine, Paracetamol belongs to more than one drug category, and Humann Superbeets Heart Chews interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Humann Superbeets Heart Chews and Codeine, Paracetamol interaction?
We rate it Minor. This interaction is generally not clinically significant, but it remains worth noting and discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.