Eplerenone drug information

Why is this medication prescribed?
How should this medicine be used?
Other uses for this medicine
What special precautions should I follow?
What special dietary instructions should I follow?
What should I do if I forget a dose?
What side effects can this medication cause?
What should I know about STORAGE and DISPOSAL of this medication?
What should I do in case of OVERDOSE?
What OTHER INFORMATION should I know?
Drug interactions

Why is this medication prescribed?

Eplerenone is used alone or in combination with other medications to treat high blood pressure. Eplerenone is in a class of medications called mineralocorticoid receptor antagonists. It works by blocking the action of aldosterone, a natural substance in the body that raises blood pressure.

High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.

How should this medicine be used?

Eplerenone comes as a tablet to take by mouth. It is usually taken once or twice a day, with or without food. To help you remember to take eplerenone, take it around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take eplerenone exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor may start you on a low dose of eplerenone and increase your dose after 4 weeks.

Eplerenone controls high blood pressure but does not cure it. It may take 4 weeks or longer before you feel the full benefit of eplerenone. Continue to take eplerenone even if you feel well. Do not stop taking eplerenone without talking to your doctor.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking eplerenone,

tell your doctor and pharmacist if you are allergic to eplerenone, any other medications, or any ingredients in eplerenone tablets. Ask your pharmacist for a list of the ingredients.

do not take eplerenone if you are taking amiloride (Midamor), amiloride and hydrochlorothiazide, itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), potassium supplements, spironolactone (Aldactone), spironolactone and hydrochlorothiazide (Aldactazide), triamterene (Dyrenium), or triamterene and hydrochlorothiazide (Dyazide, Maxzide).

tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking. Be sure to mention any of the following: angiotensin converting enzyme (ACE) inhibitors such as benazepril (Lotensin, in Lotrel), captopril (Capoten), enalapril (Vasotec, in Vaseretic), fosinopril, lisinopril (in Prinzide, in Zestoretic), and quinapril (Accupril, in Accuretic, in Quinaretic); angiotensin II receptor antagonists such as azilsartan (Edarbi, in Edarbyclor), candesartan (Atacand, in Atacand HCT), eprosartan (Teveten), irbesartan (Avapro, in Avalide), losartan (Cozaar, in Hyzaar), olmesartan (Benicar, in Azor, in Benicar HCT), telmisartan (Micardis, in Micardis HCT, in Twynsta), and valsartan (Diovan, in Diovan HCT, Exforge); aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); cimetidine (Tagamet); clarithromycin (Biaxin); danazol; delavirdine (Rescriptor); diltiazem (Cardizem, Dilacor, Tiazac, others); erythromycin (E.E.S., E-Mycin, Erythrocin); fluconazole (Diflucan); fluoxetine (Prozac, Sarafem, Selfemra); fluvoxamine (Luvox); HIV protease inhibitors such as indinavir (Crixivan), ritonavir (Norvir, in Kaletra), and saquinavir (Invirase); isoniazid (Laniazid, in Rifamate, Rifater); lithium (Lithobid); metronidazole (Flagyl); nefazodone; verapamil (Calan, Covera, Verelan, in Tarka); and zafirlukast (Accolate). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

tell your doctor what herbal products you are taking, especially St. John's wort.

tell your doctor if you have or have ever had high blood levels of potassium, diabetes, gout, or liver or kidney disease.

tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking eplerenone, call your doctor.

What special dietary instructions should I follow?

Talk to your doctor about drinking grapefruit juice while taking this medicine.

Do not use salt substitutes containing potassium while you are taking eplerenone. If your doctor prescribes a low-salt or low-sodium diet, follow these directions carefully.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Eplerenone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- headache
- dizziness
- diarrhea
- stomach pain
- cough
- excessive tiredness
- flu-like symptoms
- breast enlargement or tenderness
- abnormal vaginal bleeding

Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them, call your doctor immediately:
- chest pain
- tingling in arms and legs
- loss of muscle tone
- weakness or heaviness in legs
- confusion
- lack of energy
- cold, gray skin
- irregular heartbeat
Eplerenone may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What should I know about STORAGE and DISPOSAL of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

What should I do in case of OVERDOSE?

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

fainting
dizziness
blurred vision
upset stomach
tingling in arms and legs
loss of muscle tone
weakness or heaviness in legs
confusion
lack of energy
cold, gray skin
irregular or slow heartbeat

What OTHER INFORMATION should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will check your blood pressure regularly and order certain lab tests to check your body's response to eplerenone.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug interactions

Drug	Interaction
Delavirdine	Delavirdine The metabolism of Eplerenone can be decreased when combined with Delavirdine.
Nevirapine	Nevirapine The metabolism of Eplerenone can be decreased when combined with Nevirapine.
Atorvastatin	Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Eplerenone.
Bisacodyl	Bisacodyl The risk or severity of adverse effects can be increased when Eplerenone is combined with Bisacodyl.
Candesartan	Candesartan The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Candesartan.
Cilostazol	Cilostazol Eplerenone may increase the excretion rate of Cilostazol which could result in a lower serum level and potentially a reduction in efficacy.
Clopidogrel	Clopidogrel The metabolism of Clopidogrel can be decreased when combined with Eplerenone.
Diphenoxylate	Diphenoxylate The therapeutic efficacy of Eplerenone can be decreased when used in combination with Diphenoxylate.
Erythromycin and Sulfisoxazole	Erythromycin and Sulfisoxazole The metabolism of Eplerenone can be decreased when combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives)	Estrogen and Progestin (Oral Contraceptives) Eplerenone may increase the excretion rate of Conjugated estrogens which could result in a lower serum level and potentially a reduction in efficacy.
Fenofibrate	Fenofibrate Eplerenone may increase the excretion rate of Fenofibrate which could result in a lower serum level and potentially a reduction in efficacy.
Guanfacine	Guanfacine Guanfacine may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Magnesium Hydroxide	Magnesium Hydroxide The risk or severity of adverse effects can be increased when Eplerenone is combined with Magnesium hydroxide.
Magnesium Oxide	Magnesium Oxide The risk or severity of adverse effects can be increased when Eplerenone is combined with Magnesium oxide.
Methylergonovine	Methylergonovine Methylergometrine may decrease the antihypertensive activities of Eplerenone.
Mycophenolate	Mycophenolate Eplerenone may increase the excretion rate of Mycophenolic acid which could result in a lower serum level and potentially a reduction in efficacy.
Naratriptan	Naratriptan Naratriptan may decrease the antihypertensive activities of Eplerenone.
Olsalazine	Olsalazine The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Olsalazine is combined with Eplerenone.
Paregoric	Paregoric The therapeutic efficacy of Eplerenone can be decreased when used in combination with Morphine.
Penbutolol	Penbutolol The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Acebutolol.
Pentazocine	Pentazocine The therapeutic efficacy of Eplerenone can be decreased when used in combination with Pentazocine.
Polyethylene glycol-electrolyte solution (PEG-ES)	Polyethylene glycol-electrolyte solution (PEG-ES) The risk or severity of adverse effects can be increased when Eplerenone is combined with Polyethylene glycol.
Potassium	Potassium The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Potassium cation.
Prednisone	Prednisone Eplerenone may increase the excretion rate of Prednisone which could result in a lower serum level and potentially a reduction in efficacy.
Psyllium	Psyllium The risk or severity of adverse effects can be increased when Eplerenone is combined with Plantago seed.
Ranitidine	Ranitidine Eplerenone may increase the excretion rate of Ranitidine which could result in a lower serum level and potentially a reduction in efficacy.
Reserpine	Reserpine The metabolism of Eplerenone can be increased when combined with Reserpine.
Rizatriptan	Rizatriptan Eplerenone may increase the excretion rate of Rizatriptan which could result in a lower serum level and potentially a reduction in efficacy.
Sumatriptan	Sumatriptan Eplerenone may increase the excretion rate of Sumatriptan which could result in a lower serum level and potentially a reduction in efficacy.
Tacrolimus	Tacrolimus The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Tacrolimus.
Tizanidine	Tizanidine The risk or severity of adverse effects can be increased when Tizanidine is combined with Eplerenone.
Triamcinolone	Triamcinolone The metabolism of Eplerenone can be increased when combined with Triamcinolone.
Zolmitriptan	Zolmitriptan Zolmitriptan may decrease the antihypertensive activities of Eplerenone.
Ampicillin Injection	Ampicillin Injection Eplerenone may increase the excretion rate of Ampicillin which could result in a lower serum level and potentially a reduction in efficacy.
Doxycycline Injection	Doxycycline Injection Eplerenone may increase the excretion rate of Doxycycline which could result in a lower serum level and potentially a reduction in efficacy.
Fluconazole Injection	Fluconazole Injection The metabolism of Eplerenone can be decreased when combined with Fluconazole.
Hydromorphone Injection	Hydromorphone Injection The therapeutic efficacy of Eplerenone can be decreased when used in combination with Hydromorphone.
Levofloxacin Injection	Levofloxacin Injection Eplerenone may increase the excretion rate of Levofloxacin which could result in a lower serum level and potentially a reduction in efficacy.
Meperidine Injection	Meperidine Injection Eplerenone may increase the excretion rate of Meperidine which could result in a lower serum level and potentially a reduction in efficacy.
Metoclopramide Injection	Metoclopramide Injection Eplerenone may increase the excretion rate of Metoclopramide which could result in a lower serum level and potentially a reduction in efficacy.
Metronidazole Injection	Metronidazole Injection The metabolism of Metronidazole can be decreased when combined with Eplerenone.
Morphine Injection	Morphine Injection The therapeutic efficacy of Eplerenone can be decreased when used in combination with Morphine.
Vancomycin Injection	Vancomycin Injection Eplerenone may increase the excretion rate of Vancomycin which could result in a lower serum level and potentially a reduction in efficacy.
Altretamine	Altretamine Amphetamine may increase the orthostatic hypotensive activities of Eplerenone.
Cyclosporine	Cyclosporine The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Cyclosporine.
Ondansetron	Ondansetron The metabolism of Ondansetron can be decreased when combined with Eplerenone.
Enoxaparin Injection	Enoxaparin Injection The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Enoxaparin.
Torsemide	Torsemide Torasemide may increase the hypotensive activities of Eplerenone.
Olanzapine	Olanzapine The risk or severity of adverse effects can be increased when Olanzapine is combined with Eplerenone.
Eprosartan	Eprosartan The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Eprosartan.
Meloxicam	Meloxicam The therapeutic efficacy of Eplerenone can be decreased when used in combination with Meloxicam.
Oxcarbazepine	Oxcarbazepine The metabolism of Eplerenone can be increased when combined with Oxcarbazepine.
Pantoprazole	Pantoprazole Eplerenone may increase the excretion rate of Pantoprazole which could result in a lower serum level and potentially a reduction in efficacy.
Telmisartan	Telmisartan The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Telmisartan.
Temozolomide	Temozolomide Eplerenone may increase the excretion rate of Temozolomide which could result in a lower serum level and potentially a reduction in efficacy.
Zaleplon	Zaleplon Eplerenone may increase the excretion rate of Zaleplon which could result in a lower serum level and potentially a reduction in efficacy.
Anakinra	Anakinra The metabolism of Eplerenone can be increased when combined with Anakinra.
Linezolid	Linezolid Linezolid may increase the orthostatic hypotensive activities of Eplerenone.
Trimipramine	Trimipramine Trimipramine may decrease the antihypertensive activities of Eplerenone.
Etanercept Injection	Etanercept Injection The metabolism of Eplerenone can be increased when combined with Etanercept.
Modafinil	Modafinil The metabolism of Eplerenone can be increased when combined with Modafinil.
Perindopril	Perindopril Eplerenone may increase the hyperkalemic activities of Perindopril.
Tenofovir	Tenofovir Eplerenone may increase the excretion rate of Tenofovir which could result in a lower serum level and potentially a reduction in efficacy.
Choline Magnesium Trisalicylate	Choline Magnesium Trisalicylate The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Choline magnesium trisalicylate is combined with Eplerenone.
Sirolimus	Sirolimus The metabolism of Sirolimus can be decreased when combined with Eplerenone.
Dutasteride	Dutasteride The metabolism of Dutasteride can be decreased when combined with Eplerenone.
Epinephrine Injection	Epinephrine Injection The risk or severity of Cardiac Arrhythmia can be increased when Epinephrine is combined with Eplerenone.
Olmesartan	Olmesartan The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Olmesartan.
Zonisamide	Zonisamide Eplerenone may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Adalimumab Injection	Adalimumab Injection The metabolism of Eplerenone can be increased when combined with Adalimumab.
Aripiprazole	Aripiprazole The risk or severity of hypotension can be increased when Aripiprazole is combined with Eplerenone.
Atomoxetine	Atomoxetine Eplerenone may increase the excretion rate of Atomoxetine which could result in a lower serum level and potentially a reduction in efficacy.
Dexmethylphenidate	Dexmethylphenidate Dexmethylphenidate may decrease the antihypertensive activities of Eplerenone.
Atazanavir	Atazanavir The metabolism of Eplerenone can be decreased when combined with Atazanavir.
Almotriptan	Almotriptan Almotriptan may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Eletriptan	Eletriptan Eletriptan may decrease the antihypertensive activities of Eplerenone.
Polyethylene Glycol 3350	Polyethylene Glycol 3350 The risk or severity of adverse effects can be increased when Eplerenone is combined with Polyethylene glycol.
Rosuvastatin	Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Eplerenone.
Vardenafil	Vardenafil Eplerenone may increase the antihypertensive activities of Vardenafil.
Alfuzosin	Alfuzosin Alfuzosin may increase the hypotensive activities of Eplerenone.
Aprepitant	Aprepitant The metabolism of Eplerenone can be decreased when combined with Aprepitant.
Emtricitabine	Emtricitabine Eplerenone may increase the excretion rate of Emtricitabine which could result in a lower serum level and potentially a reduction in efficacy.
Memantine	Memantine Eplerenone may increase the excretion rate of Memantine which could result in a lower serum level and potentially a reduction in efficacy.
Tegaserod	Tegaserod The risk or severity of adverse effects can be increased when Eplerenone is combined with Tegaserod.
Tadalafil	Tadalafil Eplerenone may increase the excretion rate of Tadalafil which could result in a lower serum level and potentially a reduction in efficacy.
Frovatriptan	Frovatriptan Frovatriptan may decrease the antihypertensive activities of Eplerenone.
Progesterone	Progesterone The metabolism of Eplerenone can be decreased when combined with Progesterone.
Apomorphine Injection	Apomorphine Injection The risk or severity of adverse effects can be increased when Apomorphine is combined with Eplerenone.
Infliximab Injection	Infliximab Injection The metabolism of Eplerenone can be increased when combined with Infliximab.
Protriptyline	Protriptyline Protriptyline may decrease the antihypertensive activities of Eplerenone.
Duloxetine	Duloxetine The risk or severity of orthostatic hypotension and syncope can be increased when Eplerenone is combined with Duloxetine.
Norethindrone	Norethindrone The metabolism of Norethisterone can be decreased when combined with Eplerenone.
Tinidazole	Tinidazole Eplerenone may increase the excretion rate of Tinidazole which could result in a lower serum level and potentially a reduction in efficacy.
Bosentan	Bosentan Bosentan may increase the hypotensive activities of Eplerenone.
Cefditoren	Cefditoren Eplerenone may increase the excretion rate of Cefdinir which could result in a lower serum level and potentially a reduction in efficacy.
Cyanocobalamin Injection	Cyanocobalamin Injection Eplerenone may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
Erlotinib	Erlotinib The metabolism of Eplerenone can be decreased when combined with Erlotinib.
Eszopiclone	Eszopiclone Eplerenone may increase the excretion rate of Eszopiclone which could result in a lower serum level and potentially a reduction in efficacy.
Ganciclovir	Ganciclovir Eplerenone may increase the excretion rate of Ganciclovir which could result in a lower serum level and potentially a reduction in efficacy.
Ribavirin	Ribavirin Eplerenone may increase the excretion rate of Ribavirin which could result in a lower serum level and potentially a reduction in efficacy.
Solifenacin	Solifenacin Solifenacin may decrease the antihypertensive activities of Eplerenone.
Valganciclovir	Valganciclovir Eplerenone may increase the excretion rate of Valganciclovir which could result in a lower serum level and potentially a reduction in efficacy.
Voriconazole	Voriconazole The metabolism of Eplerenone can be decreased when combined with Voriconazole.
Dextroamphetamine	Dextroamphetamine Amphetamine may increase the orthostatic hypotensive activities of Eplerenone.
Isocarboxazid	Isocarboxazid Isocarboxazid may increase the orthostatic hypotensive activities of Eplerenone.
Ramelteon	Ramelteon Eplerenone may increase the excretion rate of Ramelteon which could result in a lower serum level and potentially a reduction in efficacy.
Fentanyl	Fentanyl Fentanyl may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Pregabalin	Pregabalin Eplerenone may increase the excretion rate of Pregabalin which could result in a lower serum level and potentially a reduction in efficacy.
Phenylephrine	Phenylephrine Phenylephrine may decrease the antihypertensive activities of Eplerenone.
Tipranavir	Tipranavir The metabolism of Tipranavir can be decreased when combined with Eplerenone.
Ranolazine	Ranolazine Eplerenone may increase the excretion rate of Ranolazine which could result in a lower serum level and potentially a reduction in efficacy.
Abatacept Injection	Abatacept Injection The metabolism of Eplerenone can be increased when combined with Abatacept.
Rasagiline	Rasagiline Rasagiline may increase the orthostatic hypotensive activities of Eplerenone.
Imatinib	Imatinib The metabolism of Eplerenone can be decreased when combined with Imatinib.
Sitagliptin	Sitagliptin Eplerenone may increase the excretion rate of Sitagliptin which could result in a lower serum level and potentially a reduction in efficacy.
Varenicline	Varenicline Eplerenone may increase the excretion rate of Varenicline which could result in a lower serum level and potentially a reduction in efficacy.
Gefitinib	Gefitinib The metabolism of Eplerenone can be decreased when combined with Gefitinib.
Albuterol	Albuterol Salbutamol may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Paliperidone	Paliperidone Eplerenone may increase the excretion rate of Paliperidone which could result in a lower serum level and potentially a reduction in efficacy.
Clofarabine Injection	Clofarabine Injection Clofarabine may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Lubiprostone	Lubiprostone The risk or severity of adverse effects can be increased when Eplerenone is combined with Lubiprostone.
Posaconazole	Posaconazole The metabolism of Eplerenone can be decreased when combined with Posaconazole.
Primaquine	Primaquine The metabolism of Eplerenone can be decreased when combined with Primaquine.
Rituximab Injection	Rituximab Injection Eplerenone may increase the hypotensive activities of Rituximab.
Aliskiren	Aliskiren The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Aliskiren.
Darunavir	Darunavir The metabolism of Darunavir can be decreased when combined with Eplerenone.
Pemetrexed Injection	Pemetrexed Injection Eplerenone may increase the excretion rate of Pemetrexed which could result in a lower serum level and potentially a reduction in efficacy.
Lisdexamfetamine	Lisdexamfetamine Lisdexamfetamine may decrease the antihypertensive activities of Eplerenone.
Nabilone	Nabilone The risk or severity of adverse effects can be increased when Nabilone is combined with Eplerenone.
Sorafenib	Sorafenib The metabolism of Eplerenone can be decreased when combined with Sorafenib.
Sunitinib	Sunitinib The metabolism of Sunitinib can be decreased when combined with Eplerenone.
Lapatinib	Lapatinib The metabolism of Lapatinib can be decreased when combined with Eplerenone.
Levocetirizine	Levocetirizine Eplerenone may increase the excretion rate of Levocetirizine which could result in a lower serum level and potentially a reduction in efficacy.
Pegaptanib Injection	Pegaptanib Injection Eplerenone may increase the excretion rate of Pegaptanib which could result in a lower serum level and potentially a reduction in efficacy.
Dasatinib	Dasatinib The metabolism of Dasatinib can be decreased when combined with Eplerenone.
Armodafinil	Armodafinil The metabolism of Eplerenone can be increased when combined with Armodafinil.
Azacitidine Injection	Azacitidine Injection Eplerenone may increase the excretion rate of Azacitidine which could result in a lower serum level and potentially a reduction in efficacy.
Paclitaxel (with polyoxyethylated castor oil) Injection	Paclitaxel (with polyoxyethylated castor oil) Injection The risk or severity of adverse effects can be increased when Eplerenone is combined with Castor oil.
Temsirolimus	Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Eplerenone.
Lenalidomide	Lenalidomide Eplerenone may increase the excretion rate of Lenalidomide which could result in a lower serum level and potentially a reduction in efficacy.
Nilotinib	Nilotinib The metabolism of Eplerenone can be decreased when combined with Nilotinib.
Budesonide	Budesonide The metabolism of Eplerenone can be increased when combined with Budesonide.
Chloramphenicol Injection	Chloramphenicol Injection The metabolism of Eplerenone can be decreased when combined with Chloramphenicol.
Desmopressin	Desmopressin Eplerenone may increase the excretion rate of Desmopressin which could result in a lower serum level and potentially a reduction in efficacy.
Doripenem Injection	Doripenem Injection Eplerenone may increase the excretion rate of Doripenem which could result in a lower serum level and potentially a reduction in efficacy.
Arsenic Trioxide Injection	Arsenic Trioxide Injection Arsenic trioxide may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Desvenlafaxine	Desvenlafaxine The metabolism of Eplerenone can be decreased when combined with Desvenlafaxine.
Cevimeline	Cevimeline Eplerenone may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
Nebivolol	Nebivolol The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Nebivolol.
Tretinoin	Tretinoin The metabolism of Tretinoin can be decreased when combined with Eplerenone.
Certolizumab Injection	Certolizumab Injection The metabolism of Eplerenone can be increased when combined with Certolizumab pegol.
Irinotecan Injection	Irinotecan Injection The metabolism of Irinotecan can be decreased when combined with Eplerenone.
Daptomycin Injection	Daptomycin Injection Eplerenone may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy.
Praziquantel	Praziquantel The metabolism of Praziquantel can be decreased when combined with Eplerenone.
Methylnaltrexone Injection	Methylnaltrexone Injection Eplerenone may increase the excretion rate of Methylnaltrexone which could result in a lower serum level and potentially a reduction in efficacy.
Midazolam	Midazolam Midazolam may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Naltrexone Injection	Naltrexone Injection The therapeutic efficacy of Eplerenone can be decreased when used in combination with Naltrexone.
Dexrazoxane Injection	Dexrazoxane Injection Eplerenone may increase the excretion rate of Dexrazoxane which could result in a lower serum level and potentially a reduction in efficacy.
Milnacipran	Milnacipran The metabolism of Eplerenone can be decreased when combined with Milnacipran.
Plerixafor Injection	Plerixafor Injection Eplerenone may increase the excretion rate of Plerixafor which could result in a lower serum level and potentially a reduction in efficacy.
Sodium Phosphate	Sodium Phosphate Eplerenone may increase the nephrotoxic activities of Sodium phosphate, monobasic.
Fesoterodine	Fesoterodine Eplerenone may increase the excretion rate of Fesoterodine which could result in a lower serum level and potentially a reduction in efficacy.
Betaxolol	Betaxolol The risk or severity of hyperkalemia can be increased when Betaxolol is combined with Eplerenone.
Iloperidone	Iloperidone The metabolism of Iloperidone can be decreased when combined with Eplerenone.
Prasugrel	Prasugrel Eplerenone may increase the excretion rate of Prasugrel which could result in a lower serum level and potentially a reduction in efficacy.
Tolvaptan (low blood sodium)	Tolvaptan (low blood sodium) The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Tolvaptan.
Dronedarone	Dronedarone The metabolism of Dronedarone can be decreased when combined with Eplerenone.
Pralatrexate Injection	Pralatrexate Injection Eplerenone may increase the excretion rate of Pralatrexate which could result in a lower serum level and potentially a reduction in efficacy.
Palonosetron Injection	Palonosetron Injection Eplerenone may increase the excretion rate of Palonosetron which could result in a lower serum level and potentially a reduction in efficacy.
Saxagliptin	Saxagliptin Eplerenone may increase the excretion rate of Saxagliptin which could result in a lower serum level and potentially a reduction in efficacy.
Telavancin Injection	Telavancin Injection Eplerenone may increase the excretion rate of Telavancin which could result in a lower serum level and potentially a reduction in efficacy.
Romidepsin Injection	Romidepsin Injection The metabolism of Romidepsin can be decreased when combined with Eplerenone.
Tapentadol	Tapentadol The therapeutic efficacy of Eplerenone can be decreased when used in combination with Tapentadol.
Topotecan	Topotecan Eplerenone may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Golimumab Injection	Golimumab Injection The metabolism of Eplerenone can be increased when combined with Golimumab.
Asenapine	Asenapine Asenapine may decrease the antihypertensive activities of Eplerenone.
Levonorgestrel	Levonorgestrel The metabolism of Eplerenone can be decreased when combined with Levonorgestrel.
Oxymorphone	Oxymorphone The therapeutic efficacy of Eplerenone can be decreased when used in combination with Oxymorphone.
Tocilizumab Injection	Tocilizumab Injection The metabolism of Eplerenone can be increased when combined with Tocilizumab.
Dalfampridine	Dalfampridine Eplerenone may increase the excretion rate of Dalfampridine which could result in a lower serum level and potentially a reduction in efficacy.
Cabazitaxel Injection	Cabazitaxel Injection The metabolism of Cabazitaxel can be decreased when combined with Eplerenone.
Lurasidone	Lurasidone Lurasidone may decrease the antihypertensive activities of Eplerenone.
Acetaminophen Injection	Acetaminophen Injection Eplerenone may increase the excretion rate of Acetaminophen which could result in a lower serum level and potentially a reduction in efficacy.
Vilazodone	Vilazodone Vilazodone may decrease the antihypertensive activities of Eplerenone.
Ipilimumab Injection	Ipilimumab Injection Eplerenone may increase the excretion rate of Ipilimumab which could result in a lower serum level and potentially a reduction in efficacy.
Denileukin Diftitox Injection	Denileukin Diftitox Injection Aldesleukin may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Terbutaline Injection	Terbutaline Injection Eplerenone may increase the excretion rate of Terbutaline which could result in a lower serum level and potentially a reduction in efficacy.
Azilsartan	Azilsartan The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Azilsartan medoxomil.
Roflumilast	Roflumilast Eplerenone may increase the excretion rate of Roflumilast which could result in a lower serum level and potentially a reduction in efficacy.
Linagliptin	Linagliptin The metabolism of Eplerenone can be decreased when combined with Linagliptin.
Potassium Iodide	Potassium Iodide The risk or severity of hyperkalemia can be increased when Potassium Iodide is combined with Eplerenone.
Cyclophosphamide Injection	Cyclophosphamide Injection The metabolism of Eplerenone can be decreased when combined with Cyclophosphamide.
Rivaroxaban	Rivaroxaban Eplerenone may increase the excretion rate of Rivaroxaban which could result in a lower serum level and potentially a reduction in efficacy.
Ruxolitinib	Ruxolitinib Eplerenone may increase the excretion rate of Ruxolitinib which could result in a lower serum level and potentially a reduction in efficacy.
Clobazam	Clobazam Eplerenone may increase the excretion rate of Clobazam which could result in a lower serum level and potentially a reduction in efficacy.
Ivacaftor	Ivacaftor The metabolism of Ivacaftor can be decreased when combined with Eplerenone.
Deferiprone	Deferiprone Eplerenone may increase the excretion rate of Deferiprone which could result in a lower serum level and potentially a reduction in efficacy.
Axitinib	Axitinib The metabolism of Axitinib can be decreased when combined with Eplerenone.
Crizotinib	Crizotinib The metabolism of Eplerenone can be decreased when combined with Crizotinib.
Cabergoline	Cabergoline Cabergoline may decrease the antihypertensive activities of Eplerenone.
Naloxone Injection	Naloxone Injection The metabolism of Eplerenone can be decreased when combined with Naloxone.
Ambrisentan	Ambrisentan The metabolism of Ambrisentan can be decreased when combined with Eplerenone.
Fondaparinux Injection	Fondaparinux Injection Eplerenone may increase the excretion rate of Fondaparinux which could result in a lower serum level and potentially a reduction in efficacy.
Iloprost	Iloprost Iloprost may increase the hypotensive activities of Eplerenone.
Enzalutamide	Enzalutamide Eplerenone may increase the excretion rate of Enzalutamide which could result in a lower serum level and potentially a reduction in efficacy.
Mirabegron	Mirabegron Mirabegron may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Linaclotide	Linaclotide The risk or severity of adverse effects can be increased when Eplerenone is combined with Linaclotide.
Teduglutide Injection	Teduglutide Injection Eplerenone may increase the excretion rate of Teduglutide which could result in a lower serum level and potentially a reduction in efficacy.
Alogliptin	Alogliptin Eplerenone may increase the excretion rate of Alogliptin which could result in a lower serum level and potentially a reduction in efficacy.
Ponatinib	Ponatinib The metabolism of Ponatinib can be decreased when combined with Eplerenone.
Pomalidomide	Pomalidomide Eplerenone may increase the excretion rate of Pomalidomide which could result in a lower serum level and potentially a reduction in efficacy.
Ado-trastuzumab Emtansine Injection	Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be decreased when combined with Eplerenone.
Apixaban	Apixaban The metabolism of Apixaban can be decreased when combined with Eplerenone.
Canagliflozin	Canagliflozin Canagliflozin may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Methazolamide	Methazolamide The risk or severity of adverse effects can be increased when Methazolamide is combined with Eplerenone.
Trametinib	Trametinib Eplerenone may increase the excretion rate of Trametinib which could result in a lower serum level and potentially a reduction in efficacy.
Levomilnacipran	Levomilnacipran Eplerenone may increase the excretion rate of Levomilnacipran which could result in a lower serum level and potentially a reduction in efficacy.
Ertapenem Injection	Ertapenem Injection Eplerenone may increase the excretion rate of Ertapenem which could result in a lower serum level and potentially a reduction in efficacy.
Vortioxetine	Vortioxetine Eplerenone may increase the excretion rate of Vortioxetine which could result in a lower serum level and potentially a reduction in efficacy.
Perampanel	Perampanel The metabolism of Perampanel can be decreased when combined with Eplerenone.
Ibrutinib	Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Eplerenone.
Avanafil	Avanafil Avanafil may increase the antihypertensive activities of Eplerenone.
Ketorolac Injection	Ketorolac Injection The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Ketorolac is combined with Eplerenone.
Obinutuzumab Injection	Obinutuzumab Injection Eplerenone may increase the hypotensive activities of Obinutuzumab.
Simeprevir	Simeprevir The metabolism of Eplerenone can be decreased when combined with Simeprevir.
Sofosbuvir	Sofosbuvir Eplerenone may increase the excretion rate of Sofosbuvir which could result in a lower serum level and potentially a reduction in efficacy.
Dapagliflozin	Dapagliflozin The risk or severity of adverse effects can be increased when Dapagliflozin is combined with Eplerenone.
Apremilast	Apremilast The metabolism of Eplerenone can be increased when combined with Apremilast.
Droxidopa	Droxidopa The risk or severity of Cardiac Arrhythmia can be increased when Droxidopa is combined with Eplerenone.
Siltuximab Injection	Siltuximab Injection The metabolism of Eplerenone can be increased when combined with Siltuximab.
Testosterone Injection	Testosterone Injection Testosterone may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Empagliflozin	Empagliflozin Empagliflozin may increase the diuretic activities of Eplerenone.
Hydrocodone	Hydrocodone The therapeutic efficacy of Eplerenone can be decreased when used in combination with Hydrocodone.
Edoxaban	Edoxaban Eplerenone may increase the excretion rate of Edoxaban which could result in a lower serum level and potentially a reduction in efficacy.
Olaparib	Olaparib The metabolism of Olaparib can be decreased when combined with Eplerenone.
Methamphetamine	Methamphetamine Eplerenone may increase the excretion rate of Metamfetamine which could result in a lower serum level and potentially a reduction in efficacy.
Tasimelteon	Tasimelteon Eplerenone may increase the excretion rate of Tasimelteon which could result in a lower serum level and potentially a reduction in efficacy.
Riociguat	Riociguat Eplerenone may increase the hypotensive activities of Riociguat.
Secukinumab Injection	Secukinumab Injection The metabolism of Eplerenone can be increased when combined with Secukinumab.
Risperidone Injection	Risperidone Injection Eplerenone may increase the hypotensive activities of Risperidone.
Dinutuximab Injection	Dinutuximab Injection The risk or severity of adverse effects can be increased when Dinutuximab is combined with Eplerenone.
Haloperidol Injection	Haloperidol Injection The metabolism of Eplerenone can be decreased when combined with Haloperidol.
Amiloride	Amiloride The risk or severity of hyperkalemia can be increased when Amiloride is combined with Eplerenone.
Isavuconazonium Injection	Isavuconazonium Injection The metabolism of Eplerenone can be decreased when combined with Isavuconazonium.
Macitentan	Macitentan Eplerenone may increase the excretion rate of Macitentan which could result in a lower serum level and potentially a reduction in efficacy.
Flibanserin	Flibanserin Flibanserin may decrease the antihypertensive activities of Eplerenone.
Daclatasvir	Daclatasvir The metabolism of Daclatasvir can be decreased when combined with Eplerenone.
Brexpiprazole	Brexpiprazole Brexpiprazole may decrease the antihypertensive activities of Eplerenone.
Ziprasidone Injection	Ziprasidone Injection The metabolism of Eplerenone can be decreased when combined with Ziprasidone.
Cariprazine	Cariprazine Cariprazine may decrease the antihypertensive activities of Eplerenone.
Penicillin G Procaine Injection	Penicillin G Procaine Injection Eplerenone may increase the excretion rate of Procaine benzylpenicillin which could result in a lower serum level and potentially a reduction in efficacy.
Eluxadoline	Eluxadoline The therapeutic efficacy of Eplerenone can be decreased when used in combination with Eluxadoline.
Ixazomib	Ixazomib Eplerenone may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
Lesinurad	Lesinurad Eplerenone may increase the excretion rate of Lesinurad which could result in a lower serum level and potentially a reduction in efficacy.
Amphotericin B Liposomal Injection	Amphotericin B Liposomal Injection The risk or severity of adverse effects can be increased when Amphotericin B is combined with Eplerenone.
Dexamethasone Injection	Dexamethasone Injection The metabolism of Eplerenone can be increased when combined with Dexamethasone.
Brivaracetam Injection	Brivaracetam Injection Eplerenone may increase the excretion rate of Brivaracetam which could result in a lower serum level and potentially a reduction in efficacy.
Venetoclax	Venetoclax The metabolism of Eplerenone can be decreased when combined with Venetoclax.
Cobicistat	Cobicistat The metabolism of Eplerenone can be decreased when combined with Cobicistat.
Midodrine	Midodrine Midodrine may decrease the antihypertensive activities of Eplerenone.
Selexipag	Selexipag Eplerenone may increase the hypotensive activities of Selexipag.
Furosemide Injection	Furosemide Injection Furosemide may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Rucaparib	Rucaparib The metabolism of Eplerenone can be decreased when combined with Rucaparib.
Lixisenatide Injection	Lixisenatide Injection Eplerenone may increase the excretion rate of Lixisenatide which could result in a lower serum level and potentially a reduction in efficacy.
Ribociclib	Ribociclib The metabolism of Eplerenone can be decreased when combined with Ribociclib.
Doxepin (Insomnia)	Doxepin (Insomnia) Doxepin may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Plecanatide	Plecanatide The risk or severity of adverse effects can be increased when Eplerenone is combined with Plecanatide.
Deutetrabenazine	Deutetrabenazine Eplerenone may increase the excretion rate of Deutetrabenazine which could result in a lower serum level and potentially a reduction in efficacy.
Valbenazine	Valbenazine Eplerenone may increase the excretion rate of Valbenazine which could result in a lower serum level and potentially a reduction in efficacy.
Deflazacort	Deflazacort The metabolism of Eplerenone can be increased when combined with Deflazacort.
Safinamide	Safinamide The metabolism of Eplerenone can be decreased when combined with Safinamide.
Naldemedine	Naldemedine Eplerenone may increase the excretion rate of Naldemedine which could result in a lower serum level and potentially a reduction in efficacy.
Midostaurin	Midostaurin The metabolism of Eplerenone can be decreased when combined with Midostaurin.
Benznidazole	Benznidazole Eplerenone may increase the excretion rate of Benznidazole which could result in a lower serum level and potentially a reduction in efficacy.
Copanlisib Injection	Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Eplerenone.
Delafloxacin	Delafloxacin Eplerenone may increase the excretion rate of Delafloxacin which could result in a lower serum level and potentially a reduction in efficacy.
Acalabrutinib	Acalabrutinib The metabolism of Eplerenone can be decreased when combined with Acalabrutinib.
Letermovir	Letermovir The metabolism of Eplerenone can be decreased when combined with Letermovir.
Buprenorphine Injection	Buprenorphine Injection The therapeutic efficacy of Buprenorphine can be decreased when used in combination with Eplerenone.
Apalutamide	Apalutamide Eplerenone may increase the excretion rate of Apalutamide which could result in a lower serum level and potentially a reduction in efficacy.
Fostamatinib	Fostamatinib Fostamatinib may increase the antihypertensive activities of Eplerenone.
Baricitinib	Baricitinib Eplerenone may increase the excretion rate of Baricitinib which could result in a lower serum level and potentially a reduction in efficacy.
Lofexidine	Lofexidine Eplerenone may increase the excretion rate of Lofexidine which could result in a lower serum level and potentially a reduction in efficacy.
Plazomicin Injection	Plazomicin Injection Eplerenone may increase the excretion rate of Plazomicin which could result in a lower serum level and potentially a reduction in efficacy.
Doravirine	Doravirine The metabolism of Doravirine can be decreased when combined with Eplerenone.
Cannabidiol	Cannabidiol The metabolism of Eplerenone can be decreased when combined with Cannabidiol.
Stiripentol	Stiripentol The metabolism of Eplerenone can be decreased when combined with Stiripentol.
Lorlatinib	Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Eplerenone.
Paclitaxel (with albumin) Injection	Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Eplerenone.
Prucalopride	Prucalopride The risk or severity of adverse effects can be increased when Eplerenone is combined with Prucalopride.
Magnesium Citrate	Magnesium Citrate The risk or severity of adverse effects can be increased when Eplerenone is combined with Magnesium citrate.
Emapalumab-lzsg Injection	Emapalumab-lzsg Injection The metabolism of Eplerenone can be increased when combined with Emapalumab.
Siponimod	Siponimod Siponimod may decrease the antihypertensive activities of Eplerenone.
Acyclovir Ophthalmic	Acyclovir Ophthalmic Eplerenone may increase the excretion rate of Acyclovir which could result in a lower serum level and potentially a reduction in efficacy.
Solriamfetol	Solriamfetol Eplerenone may increase the excretion rate of Solriamfetol which could result in a lower serum level and potentially a reduction in efficacy.
Istradefylline	Istradefylline The metabolism of Istradefylline can be decreased when combined with Eplerenone.
Pitolisant	Pitolisant The serum concentration of Eplerenone can be decreased when it is combined with Pitolisant.
Phenytoin Injection	Phenytoin Injection The metabolism of Eplerenone can be increased when combined with Phenytoin.
Cenobamate	Cenobamate The serum concentration of Eplerenone can be decreased when it is combined with Cenobamate.
Selumetinib	Selumetinib The metabolism of Selumetinib can be decreased when combined with Eplerenone.
Tucatinib	Tucatinib The metabolism of Tucatinib can be decreased when combined with Eplerenone.
Selpercatinib	Selpercatinib Selpercatinib may decrease the antihypertensive activities of Eplerenone.
Lemborexant	Lemborexant The metabolism of Lemborexant can be decreased when combined with Eplerenone.
Pralsetinib	Pralsetinib The metabolism of Eplerenone can be decreased when combined with Pralsetinib.
Satralizumab-mwge Injection	Satralizumab-mwge Injection The serum concentration of Eplerenone can be decreased when it is combined with Satralizumab.
Naxitamab-gqgk Injection	Naxitamab-gqgk Injection Naxitamab may decrease the antihypertensive activities of Eplerenone.
Progestin-Only (drospirenone) Oral Contraceptives	Progestin-Only (drospirenone) Oral Contraceptives The risk or severity of hyperkalemia can be increased when Drospirenone is combined with Eplerenone.
Viloxazine	Viloxazine Eplerenone may increase the excretion rate of Viloxazine which could result in a lower serum level and potentially a reduction in efficacy.
Fenoprofen	Fenoprofen The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Fenoprofen is combined with Eplerenone.
Indomethacin	Indomethacin The therapeutic efficacy of Eplerenone can be decreased when used in combination with Indomethacin.
Mefenamic Acid	Mefenamic Acid The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Mefenamic acid is combined with Eplerenone.
Naproxen	Naproxen The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Naproxen is combined with Eplerenone.
Tolmetin	Tolmetin The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Tolmetin is combined with Eplerenone.
Sulindac	Sulindac The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Sulindac is combined with Eplerenone.
Trazodone	Trazodone The metabolism of Eplerenone can be decreased when combined with Trazodone.
Isotretinoin	Isotretinoin Eplerenone may increase the excretion rate of Isotretinoin which could result in a lower serum level and potentially a reduction in efficacy.
Sucralfate	Sucralfate Eplerenone may increase the excretion rate of Sucralfate which could result in a lower serum level and potentially a reduction in efficacy.
Floxuridine	Floxuridine Eplerenone may increase the excretion rate of Floxuridine which could result in a lower serum level and potentially a reduction in efficacy.
Phenobarbital	Phenobarbital The metabolism of Eplerenone can be increased when combined with Phenobarbital.
Metaxalone	Metaxalone Eplerenone may increase the excretion rate of Metaxalone which could result in a lower serum level and potentially a reduction in efficacy.
Methotrexate Injection	Methotrexate Injection Eplerenone may increase the excretion rate of Methotrexate which could result in a lower serum level and potentially a reduction in efficacy.
Levorphanol	Levorphanol The therapeutic efficacy of Eplerenone can be decreased when used in combination with Levorphanol.
Primidone	Primidone Primidone may increase the hypotensive activities of Eplerenone.
Methsuximide	Methsuximide The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Methsuximide.
Diethylpropion	Diethylpropion Diethylpropion may decrease the antihypertensive activities of Eplerenone.
Chlorpromazine	Chlorpromazine Chlorpromazine may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Diazepam	Diazepam Eplerenone may increase the excretion rate of Diazepam which could result in a lower serum level and potentially a reduction in efficacy.
Oxazepam	Oxazepam Eplerenone may increase the excretion rate of Oxazepam which could result in a lower serum level and potentially a reduction in efficacy.
Flurazepam	Flurazepam Eplerenone may increase the excretion rate of Flurazepam which could result in a lower serum level and potentially a reduction in efficacy.
Clorazepate	Clorazepate Eplerenone may increase the excretion rate of Clorazepic acid which could result in a lower serum level and potentially a reduction in efficacy.
Lorazepam	Lorazepam Eplerenone may increase the excretion rate of Lorazepam which could result in a lower serum level and potentially a reduction in efficacy.
Phenoxybenzamine	Phenoxybenzamine Eplerenone may decrease the antihypertensive activities of Phenoxybenzamine.
Carmustine	Carmustine Eplerenone may increase the excretion rate of Carmustine which could result in a lower serum level and potentially a reduction in efficacy.
Amantadine	Amantadine Eplerenone may increase the excretion rate of Amantadine which could result in a lower serum level and potentially a reduction in efficacy.
Codeine	Codeine Eplerenone may increase the excretion rate of Codeine which could result in a lower serum level and potentially a reduction in efficacy.
Bromocriptine	Bromocriptine Bromocriptine may decrease the antihypertensive activities of Eplerenone.
Metaproterenol	Metaproterenol Orciprenaline may decrease the antihypertensive activities of Eplerenone.
Tranylcypromine	Tranylcypromine Tranylcypromine may increase the hypotensive activities of Eplerenone.
Phenelzine	Phenelzine Phenelzine may increase the hypotensive activities of Eplerenone.
Procarbazine	Procarbazine Procarbazine may increase the orthostatic hypotensive activities of Eplerenone.
Ergoloid Mesylates	Ergoloid Mesylates Ergoloid mesylate may decrease the antihypertensive activities of Eplerenone.
Tetracycline	Tetracycline Eplerenone may increase the excretion rate of Tetracycline which could result in a lower serum level and potentially a reduction in efficacy.
Thioridazine	Thioridazine Thioridazine may decrease the antihypertensive activities of Eplerenone.
Trifluoperazine	Trifluoperazine Trifluoperazine may decrease the antihypertensive activities of Eplerenone.
Bleomycin	Bleomycin Eplerenone may increase the excretion rate of Bleomycin which could result in a lower serum level and potentially a reduction in efficacy.
Dapsone	Dapsone The metabolism of Eplerenone can be decreased when combined with Dapsone.
Sulfadiazine	Sulfadiazine Eplerenone may increase the excretion rate of Sulfadiazine which could result in a lower serum level and potentially a reduction in efficacy.
Oxycodone	Oxycodone The therapeutic efficacy of Eplerenone can be decreased when used in combination with Oxycodone.
Methadone	Methadone Methadone may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Oxybutynin	Oxybutynin The metabolism of Oxybutynin can be decreased when combined with Eplerenone.
Benztropine	Benztropine Eplerenone may increase the excretion rate of Benzatropine which could result in a lower serum level and potentially a reduction in efficacy.
Maprotiline	Maprotiline Eplerenone may increase the excretion rate of Maprotiline which could result in a lower serum level and potentially a reduction in efficacy.
Ibuprofen	Ibuprofen The therapeutic efficacy of Eplerenone can be decreased when used in combination with Ibuprofen.
Azathioprine	Azathioprine Eplerenone may increase the excretion rate of Azathioprine which could result in a lower serum level and potentially a reduction in efficacy.
Phentermine	Phentermine Phentermine may decrease the antihypertensive activities of Eplerenone.
Methylphenidate	Methylphenidate Methylphenidate may decrease the antihypertensive activities of Eplerenone.
Amoxapine	Amoxapine Amoxapine may decrease the antihypertensive activities of Eplerenone.
Sulfasalazine	Sulfasalazine The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Sulfasalazine is combined with Eplerenone.
Hydrocortisone	Hydrocortisone The metabolism of Hydrocortisone can be decreased when combined with Eplerenone.
Phenazopyridine	Phenazopyridine Eplerenone may increase the excretion rate of Phenazopyridine which could result in a lower serum level and potentially a reduction in efficacy.
Carbamazepine	Carbamazepine The metabolism of Carbamazepine can be decreased when combined with Eplerenone.
Methyldopa	Methyldopa Eplerenone may increase the excretion rate of Methyldopa which could result in a lower serum level and potentially a reduction in efficacy.
Clonidine	Clonidine The risk or severity of hypotension can be increased when Clonidine is combined with Eplerenone.
Prazosin	Prazosin The risk or severity of hypotension can be increased when Prazosin is combined with Eplerenone.
Hydralazine	Hydralazine Eplerenone may increase the excretion rate of Hydralazine which could result in a lower serum level and potentially a reduction in efficacy.
Cimetidine	Cimetidine The metabolism of Eplerenone can be decreased when combined with Cimetidine.
Warfarin	Warfarin Eplerenone may increase the excretion rate of Warfarin which could result in a lower serum level and potentially a reduction in efficacy.
Clonazepam	Clonazepam Eplerenone may increase the excretion rate of Clonazepam which could result in a lower serum level and potentially a reduction in efficacy.
Loperamide	Loperamide The metabolism of Eplerenone can be decreased when combined with Loperamide.
Promethazine	Promethazine Eplerenone may increase the excretion rate of Promethazine which could result in a lower serum level and potentially a reduction in efficacy.
Meclofenamate	Meclofenamate The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Meclofenamic acid is combined with Eplerenone.
Daunorubicin	Daunorubicin The metabolism of Eplerenone can be increased when combined with Daunorubicin.
Nitrofurantoin	Nitrofurantoin Nitrofurantoin may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Digoxin	Digoxin Eplerenone may decrease the excretion rate of Digoxin which could result in a higher serum level.
Chloroquine	Chloroquine Chloroquine may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Quinine	Quinine Quinine may increase the hypotensive activities of Eplerenone.
Ethosuximide	Ethosuximide The risk or severity of hyperkalemia can be increased when Ethosuximide is combined with Eplerenone.
Triamterene	Triamterene The risk or severity of hyperkalemia can be increased when Triamterene is combined with Eplerenone.
Lactulose	Lactulose The risk or severity of adverse effects can be increased when Eplerenone is combined with Lactulose.
Chlorothiazide	Chlorothiazide The therapeutic efficacy of Chlorothiazide can be increased when used in combination with Eplerenone.
Chlorthalidone	Chlorthalidone Chlorthalidone may increase the hypotensive activities of Eplerenone.
Metolazone	Metolazone Metolazone may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Clindamycin Injection	Clindamycin Injection The metabolism of Clindamycin can be decreased when combined with Eplerenone.
Secobarbital	Secobarbital Secobarbital may increase the hypotensive activities of Eplerenone.
Desipramine	Desipramine Desipramine may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Amitriptyline	Amitriptyline Amitriptyline may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Imipramine	Imipramine Imipramine may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Probenecid	Probenecid Eplerenone may increase the excretion rate of Probenecid which could result in a lower serum level and potentially a reduction in efficacy.
Quinidine	Quinidine The metabolism of Eplerenone can be decreased when combined with Quinidine.
Procainamide	Procainamide Eplerenone may increase the excretion rate of Procainamide which could result in a lower serum level and potentially a reduction in efficacy.
Isoniazid	Isoniazid The metabolism of Eplerenone can be decreased when combined with Isoniazid.
Pyrazinamide	Pyrazinamide Eplerenone may increase the excretion rate of Pyrazinamide which could result in a lower serum level and potentially a reduction in efficacy.
Rifampin	Rifampin The metabolism of Eplerenone can be increased when combined with Rifampicin.
Disopyramide	Disopyramide Eplerenone may increase the excretion rate of Disopyramide which could result in a lower serum level and potentially a reduction in efficacy.
Tamoxifen	Tamoxifen The metabolism of Eplerenone can be decreased when combined with Tamoxifen.
Butabarbital	Butabarbital Eplerenone may increase the excretion rate of Butabarbital which could result in a lower serum level and potentially a reduction in efficacy.
Liothyronine	Liothyronine Eplerenone may increase the excretion rate of Liothyronine which could result in a lower serum level and potentially a reduction in efficacy.
Methimazole	Methimazole The metabolism of Methimazole can be decreased when combined with Eplerenone.
Chlorpropamide	Chlorpropamide Eplerenone may increase the excretion rate of Chlorpropamide which could result in a lower serum level and potentially a reduction in efficacy.
Tolbutamide	Tolbutamide Eplerenone may increase the excretion rate of Tolbutamide which could result in a lower serum level and potentially a reduction in efficacy.
Tolazamide	Tolazamide Eplerenone may increase the excretion rate of Tolazamide which could result in a lower serum level and potentially a reduction in efficacy.
Dextromethorphan	Dextromethorphan The metabolism of Eplerenone can be decreased when combined with Dextromethorphan.
Baclofen	Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Eplerenone.
Chlorpheniramine	Chlorpheniramine The metabolism of Chlorpheniramine can be decreased when combined with Eplerenone.
Ethambutol	Ethambutol Eplerenone may increase the excretion rate of Ethambutol which could result in a lower serum level and potentially a reduction in efficacy.
Methyclothiazide	Methyclothiazide The therapeutic efficacy of Eplerenone can be increased when used in combination with Methyclothiazide.
Hydrochlorothiazide	Hydrochlorothiazide The therapeutic efficacy of Hydrochlorothiazide can be increased when used in combination with Eplerenone.
Dantrolene	Dantrolene The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Dantrolene.
Chlorzoxazone	Chlorzoxazone Eplerenone may increase the excretion rate of Chlorzoxazone which could result in a lower serum level and potentially a reduction in efficacy.
Pyridoxine	Pyridoxine Eplerenone may increase the excretion rate of Pyridoxine which could result in a lower serum level and potentially a reduction in efficacy.
Folic Acid	Folic Acid Eplerenone may increase the excretion rate of Folic acid which could result in a lower serum level and potentially a reduction in efficacy.
Danazol	Danazol The metabolism of Eplerenone can be decreased when combined with Danazol.
Disulfiram	Disulfiram The metabolism of Disulfiram can be decreased when combined with Eplerenone.
Propranolol (Cardiovascular)	Propranolol (Cardiovascular) Propranolol may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Minoxidil	Minoxidil Minoxidil may increase the hypotensive activities of Eplerenone.
Pseudoephedrine	Pseudoephedrine Pseudoephedrine may decrease the antihypertensive activities of Eplerenone.
Nortriptyline	Nortriptyline Nortriptyline may decrease the antihypertensive activities of Eplerenone.
Spironolactone	Spironolactone The risk or severity of hyperkalemia can be increased when Spironolactone is combined with Eplerenone.
Amphotericin B Injection	Amphotericin B Injection The risk or severity of adverse effects can be increased when Amphotericin B is combined with Eplerenone.
Phytonadione	Phytonadione Eplerenone may increase the excretion rate of Phylloquinone which could result in a lower serum level and potentially a reduction in efficacy.
Nadolol	Nadolol Eplerenone may increase the excretion rate of Nadolol which could result in a lower serum level and potentially a reduction in efficacy.
Butorphanol Injection	Butorphanol Injection The therapeutic efficacy of Eplerenone can be decreased when used in combination with Butorphanol.
Nalbuphine Injection	Nalbuphine Injection The therapeutic efficacy of Eplerenone can be decreased when used in combination with Nalbuphine.
Allopurinol	Allopurinol Eplerenone may increase the excretion rate of Allopurinol which could result in a lower serum level and potentially a reduction in efficacy.
Flavoxate	Flavoxate Eplerenone may increase the excretion rate of Flavoxate which could result in a lower serum level and potentially a reduction in efficacy.
Papaverine	Papaverine The risk or severity of adverse effects can be increased when Papaverine is combined with Eplerenone.
Colchicine	Colchicine Eplerenone may increase the excretion rate of Colchicine which could result in a lower serum level and potentially a reduction in efficacy.
Cefaclor	Cefaclor Eplerenone may increase the excretion rate of Cefaclor which could result in a lower serum level and potentially a reduction in efficacy.
Cefadroxil	Cefadroxil Eplerenone may increase the excretion rate of Cefadroxil which could result in a lower serum level and potentially a reduction in efficacy.
Cephalexin	Cephalexin Eplerenone may increase the excretion rate of Cephalexin which could result in a lower serum level and potentially a reduction in efficacy.
Dacarbazine	Dacarbazine Eplerenone may increase the excretion rate of Dacarbazine which could result in a lower serum level and potentially a reduction in efficacy.
Calcitonin Salmon Injection	Calcitonin Salmon Injection Eplerenone may increase the excretion rate of Salmon calcitonin which could result in a lower serum level and potentially a reduction in efficacy.
Ketoconazole	Ketoconazole The metabolism of Eplerenone can be decreased when combined with Ketoconazole.
Pyrantel	Pyrantel Eplerenone may increase the excretion rate of Pyrantel which could result in a lower serum level and potentially a reduction in efficacy.
Vincristine Injection	Vincristine Injection The metabolism of Eplerenone can be decreased when combined with Vincristine.
Captopril	Captopril Eplerenone may increase the hyperkalemic activities of Captopril.
Dipyridamole	Dipyridamole Dipyridamole may increase the antihypertensive activities of Eplerenone.
Isoxsuprine	Isoxsuprine Isoxsuprine may decrease the antihypertensive activities of Eplerenone.
Ethacrynic Acid	Ethacrynic Acid The risk or severity of adverse effects can be increased when Etacrynic acid is combined with Eplerenone.
Metoprolol	Metoprolol Metoprolol may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Hydroxyzine	Hydroxyzine The metabolism of Eplerenone can be decreased when combined with Hydroxyzine.
Aspirin	Aspirin Acetylsalicylic acid may decrease the excretion rate of Eplerenone which could result in a higher serum level.
Salsalate	Salsalate The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Salsalate is combined with Eplerenone.
Alprazolam	Alprazolam Alprazolam may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Temazepam	Temazepam Eplerenone may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
Triazolam	Triazolam Eplerenone may increase the excretion rate of Triazolam which could result in a lower serum level and potentially a reduction in efficacy.
Dicyclomine	Dicyclomine Eplerenone may increase the excretion rate of Dicyclomine which could result in a lower serum level and potentially a reduction in efficacy.
Propantheline	Propantheline Eplerenone may increase the excretion rate of Propantheline which could result in a lower serum level and potentially a reduction in efficacy.
Trimethoprim	Trimethoprim Eplerenone may increase the excretion rate of Trimethoprim which could result in a lower serum level and potentially a reduction in efficacy.
Diltiazem	Diltiazem The metabolism of Eplerenone can be decreased when combined with Diltiazem.
Nifedipine	Nifedipine Nifedipine may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Timolol	Timolol Timolol may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Verapamil	Verapamil The metabolism of Eplerenone can be decreased when combined with Verapamil.
Atenolol	Atenolol The risk or severity of hyperkalemia can be increased when Atenolol is combined with Eplerenone.
Pindolol	Pindolol Eplerenone may increase the excretion rate of Pindolol which could result in a lower serum level and potentially a reduction in efficacy.
Cisplatin Injection	Cisplatin Injection Eplerenone may increase the excretion rate of Cisplatin which could result in a lower serum level and potentially a reduction in efficacy.
Diflunisal	Diflunisal The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Diflunisal is combined with Eplerenone.
Piroxicam	Piroxicam The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Piroxicam is combined with Eplerenone.
Bumetanide	Bumetanide Bumetanide may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Etoposide	Etoposide The metabolism of Etoposide can be decreased when combined with Eplerenone.
Glyburide	Glyburide The metabolism of Glyburide can be decreased when combined with Eplerenone.
Glipizide	Glipizide Eplerenone may increase the excretion rate of Glipizide which could result in a lower serum level and potentially a reduction in efficacy.
Indapamide	Indapamide The therapeutic efficacy of Indapamide can be increased when used in combination with Eplerenone.
Amoxicillin	Amoxicillin Eplerenone may increase the excretion rate of Amoxicillin which could result in a lower serum level and potentially a reduction in efficacy.
Oxacillin Injection	Oxacillin Injection Eplerenone may increase the excretion rate of Oxacillin which could result in a lower serum level and potentially a reduction in efficacy.
Pentoxifylline	Pentoxifylline Pentoxifylline may increase the hypotensive activities of Eplerenone.
Pentamidine Injection	Pentamidine Injection The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Pentamidine.
Ceftriaxone Injection	Ceftriaxone Injection Eplerenone may increase the excretion rate of Ceftriaxone which could result in a lower serum level and potentially a reduction in efficacy.
Labetalol	Labetalol Labetalol may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Auranofin	Auranofin Eplerenone may increase the excretion rate of Auranofin which could result in a lower serum level and potentially a reduction in efficacy.
Leuprolide Injection	Leuprolide Injection Eplerenone may increase the excretion rate of Leuprolide which could result in a lower serum level and potentially a reduction in efficacy.
Gemfibrozil	Gemfibrozil Eplerenone may increase the excretion rate of Gemfibrozil which could result in a lower serum level and potentially a reduction in efficacy.
Guanabenz	Guanabenz Eplerenone may decrease the antihypertensive activities of Guanabenz.
Ceftazidime Injection	Ceftazidime Injection Eplerenone may increase the excretion rate of Ceftazidime which could result in a lower serum level and potentially a reduction in efficacy.
Ketoprofen	Ketoprofen The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Ketoprofen is combined with Eplerenone.
Cefotetan Injection	Cefotetan Injection Eplerenone may increase the excretion rate of Cefotetan which could result in a lower serum level and potentially a reduction in efficacy.
Pimozide	Pimozide The metabolism of Pimozide can be decreased when combined with Eplerenone.
Enalapril	Enalapril Eplerenone may increase the hyperkalemic activities of Enalapril.
Flurbiprofen	Flurbiprofen The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Flurbiprofen is combined with Eplerenone.
Amiodarone	Amiodarone The risk or severity of adverse effects can be increased when Amiodarone is combined with Eplerenone.
Aztreonam Injection	Aztreonam Injection Eplerenone may increase the excretion rate of Aztreonam which could result in a lower serum level and potentially a reduction in efficacy.
Buspirone	Buspirone Buspirone may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Lovastatin	Lovastatin The metabolism of Eplerenone can be decreased when combined with Lovastatin.
Ciprofloxacin	Ciprofloxacin The metabolism of Eplerenone can be decreased when combined with Ciprofloxacin.
Mesalamine	Mesalamine The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Mesalazine is combined with Eplerenone.
Diclofenac	Diclofenac The therapeutic efficacy of Eplerenone can be decreased when used in combination with Diclofenac.
Nimodipine	Nimodipine The risk or severity of hyperkalemia can be increased when Nimodipine is combined with Eplerenone.
Clozapine	Clozapine The metabolism of Eplerenone can be decreased when combined with Clozapine.
Estazolam	Estazolam Eplerenone may increase the excretion rate of Estazolam which could result in a lower serum level and potentially a reduction in efficacy.
Didanosine	Didanosine Eplerenone may increase the excretion rate of Didanosine which could result in a lower serum level and potentially a reduction in efficacy.
Pentostatin Injection	Pentostatin Injection Eplerenone may increase the excretion rate of Pentostatin which could result in a lower serum level and potentially a reduction in efficacy.
Clarithromycin	Clarithromycin The metabolism of Eplerenone can be decreased when combined with Clarithromycin.
Benazepril	Benazepril Eplerenone may increase the hyperkalemic activities of Benazepril.
Etodolac	Etodolac The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Etodolac is combined with Eplerenone.
Felodipine	Felodipine Eplerenone may increase the hypotensive activities of Felodipine.
Fosinopril	Fosinopril Eplerenone may increase the hyperkalemic activities of Fosinopril.
Nabumetone	Nabumetone The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Nabumetone is combined with Eplerenone.
Quinapril	Quinapril Eplerenone may increase the hyperkalemic activities of Quinapril.
Ramipril	Ramipril Eplerenone may increase the hyperkalemic activities of Ramipril.
Simvastatin	Simvastatin The metabolism of Eplerenone can be decreased when combined with Simvastatin.
Amlodipine	Amlodipine The risk or severity of hyperkalemia can be increased when Amlodipine is combined with Eplerenone.
Teniposide Injection	Teniposide Injection The metabolism of Eplerenone can be decreased when combined with Teniposide.
Itraconazole	Itraconazole The metabolism of Eplerenone can be decreased when combined with Itraconazole.
Lisinopril	Lisinopril Eplerenone may increase the hyperkalemic activities of Lisinopril.
Oxaprozin	Oxaprozin The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Oxaprozin is combined with Eplerenone.
Sotalol	Sotalol The risk or severity of hyperkalemia can be increased when Sotalol is combined with Eplerenone.
Bisoprolol	Bisoprolol Bisoprolol may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Doxazosin	Doxazosin Doxazosin may increase the hypotensive activities of Eplerenone.
Terazosin	Terazosin Eplerenone may increase the hypotensive activities of Terazosin.
Isradipine	Isradipine The metabolism of Eplerenone can be decreased when combined with Isradipine.
Cisapride	Cisapride The metabolism of Eplerenone can be decreased when combined with Cisapride.
Fluvastatin	Fluvastatin The metabolism of Fluvastatin can be decreased when combined with Eplerenone.
Venlafaxine	Venlafaxine Eplerenone may increase the excretion rate of Venlafaxine which could result in a lower serum level and potentially a reduction in efficacy.
Fluvoxamine	Fluvoxamine The metabolism of Eplerenone can be decreased when combined with Fluvoxamine.
Nefazodone	Nefazodone The metabolism of Eplerenone can be decreased when combined with Nefazodone.
Lamotrigine	Lamotrigine Lamotrigine may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Losartan	Losartan The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Losartan.
Valacyclovir	Valacyclovir Eplerenone may increase the excretion rate of Valaciclovir which could result in a lower serum level and potentially a reduction in efficacy.
Tramadol	Tramadol Eplerenone may increase the excretion rate of Tramadol which could result in a lower serum level and potentially a reduction in efficacy.
Carboplatin Injection	Carboplatin Injection Eplerenone may increase the excretion rate of Carboplatin which could result in a lower serum level and potentially a reduction in efficacy.
Moexipril	Moexipril Eplerenone may increase the hyperkalemic activities of Moexipril.
Ifosfamide Injection	Ifosfamide Injection The metabolism of Ifosfamide can be decreased when combined with Eplerenone.
Nicardipine	Nicardipine The metabolism of Eplerenone can be decreased when combined with Nicardipine.
Bupropion	Bupropion Eplerenone may increase the excretion rate of Bupropion which could result in a lower serum level and potentially a reduction in efficacy.
Ticlopidine	Ticlopidine Eplerenone may increase the excretion rate of Ticlopidine which could result in a lower serum level and potentially a reduction in efficacy.
Saquinavir	Saquinavir The metabolism of Saquinavir can be decreased when combined with Eplerenone.
Metformin	Metformin Eplerenone may increase the excretion rate of Metformin which could result in a lower serum level and potentially a reduction in efficacy.
Dalteparin Injection	Dalteparin Injection The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Dalteparin.
Nisoldipine	Nisoldipine Nisoldipine may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Lamivudine	Lamivudine Eplerenone may increase the excretion rate of Lamivudine which could result in a lower serum level and potentially a reduction in efficacy.
Amifostine Injection	Amifostine Injection Eplerenone may increase the hypotensive activities of Amifostine.
Acarbose	Acarbose Eplerenone may increase the excretion rate of Acarbose which could result in a lower serum level and potentially a reduction in efficacy.
Gemcitabine Injection	Gemcitabine Injection Eplerenone may increase the excretion rate of Gemcitabine which could result in a lower serum level and potentially a reduction in efficacy.
Indinavir	Indinavir The metabolism of Eplerenone can be decreased when combined with Indinavir.
Ritonavir	Ritonavir The metabolism of Eplerenone can be decreased when combined with Ritonavir.
Docetaxel Injection	Docetaxel Injection The metabolism of Docetaxel can be decreased when combined with Eplerenone.
Cidofovir Injection	Cidofovir Injection Eplerenone may increase the excretion rate of Cidofovir which could result in a lower serum level and potentially a reduction in efficacy.
Meropenem Injection	Meropenem Injection Eplerenone may increase the excretion rate of Meropenem which could result in a lower serum level and potentially a reduction in efficacy.
Clomipramine	Clomipramine Clomipramine may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Fosfomycin	Fosfomycin Eplerenone may increase the excretion rate of Fosfomycin which could result in a lower serum level and potentially a reduction in efficacy.
Mirtazapine	Mirtazapine Mirtazapine may decrease the antihypertensive activities of Eplerenone.
Trandolapril	Trandolapril Eplerenone may increase the hyperkalemic activities of Trandolapril.
Topiramate	Topiramate Eplerenone may increase the excretion rate of Topiramate which could result in a lower serum level and potentially a reduction in efficacy.
Valsartan	Valsartan The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Valsartan.
Pramipexole	Pramipexole Pramipexole may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Nelfinavir	Nelfinavir The metabolism of Eplerenone can be decreased when combined with Nelfinavir.
Carvedilol	Carvedilol The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Carvedilol.
Nilutamide	Nilutamide Eplerenone may increase the excretion rate of Nilutamide which could result in a lower serum level and potentially a reduction in efficacy.
Flutamide	Flutamide Flutamide may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Selegiline	Selegiline Selegiline may increase the hypotensive activities of Eplerenone.
Propafenone	Propafenone The risk or severity of hyperkalemia can be increased when Propafenone is combined with Eplerenone.
Irbesartan	Irbesartan The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Irbesartan.
Tamsulosin	Tamsulosin Tamsulosin may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Ropinirole	Ropinirole The risk or severity of adverse effects can be increased when Ropinirole is combined with Eplerenone.
Finasteride	Finasteride The metabolism of Finasteride can be decreased when combined with Eplerenone.
Quetiapine	Quetiapine Eplerenone may increase the hypotensive activities of Quetiapine.
Cetirizine	Cetirizine Eplerenone may increase the excretion rate of Cetirizine which could result in a lower serum level and potentially a reduction in efficacy.
Tolcapone	Tolcapone Tolcapone may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Capecitabine	Capecitabine Eplerenone may increase the excretion rate of Capecitabine which could result in a lower serum level and potentially a reduction in efficacy.
Efavirenz	Efavirenz The metabolism of Eplerenone can be decreased when combined with Efavirenz.
Abacavir	Abacavir Eplerenone may increase the excretion rate of Abacavir which could result in a lower serum level and potentially a reduction in efficacy.
Sildenafil	Sildenafil Sildenafil may increase the antihypertensive activities of Eplerenone.
Celecoxib	Celecoxib The therapeutic efficacy of Eplerenone can be decreased when used in combination with Celecoxib.
Rosiglitazone	Rosiglitazone Eplerenone may increase the excretion rate of Rosiglitazone which could result in a lower serum level and potentially a reduction in efficacy.
Tolterodine	Tolterodine Eplerenone may increase the excretion rate of Tolterodine which could result in a lower serum level and potentially a reduction in efficacy.
Thalidomide	Thalidomide The metabolism of Eplerenone can be increased when combined with Thalidomide.
Oseltamivir	Oseltamivir Eplerenone may increase the excretion rate of Oseltamivir which could result in a lower serum level and potentially a reduction in efficacy.
Balsalazide	Balsalazide The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Balsalazide is combined with Eplerenone.
Nateglinide	Nateglinide Eplerenone may increase the excretion rate of Nateglinide which could result in a lower serum level and potentially a reduction in efficacy.
Rabeprazole	Rabeprazole Eplerenone may increase the excretion rate of Rabeprazole which could result in a lower serum level and potentially a reduction in efficacy.

Eplerenone

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