Eplerenone

Generic name: Pronounced as (e pler' en one)
Brand names
  • Inspra®
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Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 02/15/2016

Eplerenone is used alone or in combination with other medications to treat high blood pressure. Eplerenone is in a class of medications called mineralocorticoid receptor antagonists. It works by blocking the action of aldosterone, a natural substance in the body that raises blood pressure.

High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.

Eplerenone comes as a tablet to take by mouth. It is usually taken once or twice a day, with or without food. To help you remember to take eplerenone, take it around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take eplerenone exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor may start you on a low dose of eplerenone and increase your dose after 4 weeks.

Eplerenone controls high blood pressure but does not cure it. It may take 4 weeks or longer before you feel the full benefit of eplerenone. Continue to take eplerenone even if you feel well. Do not stop taking eplerenone without talking to your doctor.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking eplerenone,

  • tell your doctor and pharmacist if you are allergic to eplerenone, any other medications, or any ingredients in eplerenone tablets. Ask your pharmacist for a list of the ingredients.

  • do not take eplerenone if you are taking amiloride (Midamor), amiloride and hydrochlorothiazide, itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), potassium supplements, spironolactone (Aldactone), spironolactone and hydrochlorothiazide (Aldactazide), triamterene (Dyrenium), or triamterene and hydrochlorothiazide (Dyazide, Maxzide).

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking. Be sure to mention any of the following: angiotensin converting enzyme (ACE) inhibitors such as benazepril (Lotensin, in Lotrel), captopril (Capoten), enalapril (Vasotec, in Vaseretic), fosinopril, lisinopril (in Prinzide, in Zestoretic), and quinapril (Accupril, in Accuretic, in Quinaretic); angiotensin II receptor antagonists such as azilsartan (Edarbi, in Edarbyclor), candesartan (Atacand, in Atacand HCT), eprosartan (Teveten), irbesartan (Avapro, in Avalide), losartan (Cozaar, in Hyzaar), olmesartan (Benicar, in Azor, in Benicar HCT), telmisartan (Micardis, in Micardis HCT, in Twynsta), and valsartan (Diovan, in Diovan HCT, Exforge); aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); cimetidine (Tagamet); clarithromycin (Biaxin); danazol; delavirdine (Rescriptor); diltiazem (Cardizem, Dilacor, Tiazac, others); erythromycin (E.E.S., E-Mycin, Erythrocin); fluconazole (Diflucan); fluoxetine (Prozac, Sarafem, Selfemra); fluvoxamine (Luvox); HIV protease inhibitors such as indinavir (Crixivan), ritonavir (Norvir, in Kaletra), and saquinavir (Invirase); isoniazid (Laniazid, in Rifamate, Rifater); lithium (Lithobid); metronidazole (Flagyl); nefazodone; verapamil (Calan, Covera, Verelan, in Tarka); and zafirlukast (Accolate). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor what herbal products you are taking, especially St. John's wort.

  • tell your doctor if you have or have ever had high blood levels of potassium, diabetes, gout, or liver or kidney disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking eplerenone, call your doctor.

Talk to your doctor about drinking grapefruit juice while taking this medicine.

Do not use salt substitutes containing potassium while you are taking eplerenone. If your doctor prescribes a low-salt or low-sodium diet, follow these directions carefully.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Eplerenone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • headache

    • dizziness

    • diarrhea

    • stomach pain

    • cough

    • excessive tiredness

    • flu-like symptoms

    • breast enlargement or tenderness

    • abnormal vaginal bleeding

  • Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them, call your doctor immediately:

    • chest pain

    • tingling in arms and legs

    • loss of muscle tone

    • weakness or heaviness in legs

    • confusion

    • lack of energy

    • cold, gray skin

    • irregular heartbeat

  • Eplerenone may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

  • fainting

  • dizziness

  • blurred vision

  • upset stomach

  • tingling in arms and legs

  • loss of muscle tone

  • weakness or heaviness in legs

  • confusion

  • lack of energy

  • cold, gray skin

  • irregular or slow heartbeat

Keep all appointments with your doctor and the laboratory. Your doctor will check your blood pressure regularly and order certain lab tests to check your body's response to eplerenone.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Delavirdine Delavirdine The metabolism of Eplerenone can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Eplerenone can be decreased when combined with Nevirapine.
Atorvastatin Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Eplerenone.
Bisacodyl Bisacodyl The risk or severity of adverse effects can be increased when Eplerenone is combined with Bisacodyl.
Candesartan Candesartan The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Candesartan.
Cilostazol Cilostazol Eplerenone may increase the excretion rate of Cilostazol which could result in a lower serum level and potentially a reduction in efficacy.
Clopidogrel Clopidogrel The metabolism of Clopidogrel can be decreased when combined with Eplerenone.
Diphenoxylate Diphenoxylate The therapeutic efficacy of Eplerenone can be decreased when used in combination with Diphenoxylate.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The metabolism of Eplerenone can be decreased when combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Eplerenone may increase the excretion rate of Conjugated estrogens which could result in a lower serum level and potentially a reduction in efficacy.
Fenofibrate Fenofibrate Eplerenone may increase the excretion rate of Fenofibrate which could result in a lower serum level and potentially a reduction in efficacy.
Guanfacine Guanfacine Guanfacine may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Magnesium Hydroxide Magnesium Hydroxide The risk or severity of adverse effects can be increased when Eplerenone is combined with Magnesium hydroxide.
Magnesium Oxide Magnesium Oxide The risk or severity of adverse effects can be increased when Eplerenone is combined with Magnesium oxide.
Methylergonovine Methylergonovine Methylergometrine may decrease the antihypertensive activities of Eplerenone.
Mycophenolate Mycophenolate Eplerenone may increase the excretion rate of Mycophenolic acid which could result in a lower serum level and potentially a reduction in efficacy.
Naratriptan Naratriptan Naratriptan may decrease the antihypertensive activities of Eplerenone.
Olsalazine Olsalazine The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Olsalazine is combined with Eplerenone.
Paregoric Paregoric The therapeutic efficacy of Eplerenone can be decreased when used in combination with Morphine.
Penbutolol Penbutolol The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Acebutolol.
Pentazocine Pentazocine The therapeutic efficacy of Eplerenone can be decreased when used in combination with Pentazocine.
Polyethylene glycol-electrolyte solution (PEG-ES) Polyethylene glycol-electrolyte solution (PEG-ES) The risk or severity of adverse effects can be increased when Eplerenone is combined with Polyethylene glycol.
Potassium Potassium The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Potassium cation.
Prednisone Prednisone Eplerenone may increase the excretion rate of Prednisone which could result in a lower serum level and potentially a reduction in efficacy.
Psyllium Psyllium The risk or severity of adverse effects can be increased when Eplerenone is combined with Plantago seed.
Ranitidine Ranitidine Eplerenone may increase the excretion rate of Ranitidine which could result in a lower serum level and potentially a reduction in efficacy.
Reserpine Reserpine The metabolism of Eplerenone can be increased when combined with Reserpine.
Rizatriptan Rizatriptan Eplerenone may increase the excretion rate of Rizatriptan which could result in a lower serum level and potentially a reduction in efficacy.
Sumatriptan Sumatriptan Eplerenone may increase the excretion rate of Sumatriptan which could result in a lower serum level and potentially a reduction in efficacy.
Tacrolimus Tacrolimus The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Tacrolimus.
Tizanidine Tizanidine The risk or severity of adverse effects can be increased when Tizanidine is combined with Eplerenone.
Triamcinolone Triamcinolone The metabolism of Eplerenone can be increased when combined with Triamcinolone.
Zolmitriptan Zolmitriptan Zolmitriptan may decrease the antihypertensive activities of Eplerenone.
Ampicillin Injection Ampicillin Injection Eplerenone may increase the excretion rate of Ampicillin which could result in a lower serum level and potentially a reduction in efficacy.
Doxycycline Injection Doxycycline Injection Eplerenone may increase the excretion rate of Doxycycline which could result in a lower serum level and potentially a reduction in efficacy.
Fluconazole Injection Fluconazole Injection The metabolism of Eplerenone can be decreased when combined with Fluconazole.
Hydromorphone Injection Hydromorphone Injection The therapeutic efficacy of Eplerenone can be decreased when used in combination with Hydromorphone.
Levofloxacin Injection Levofloxacin Injection Eplerenone may increase the excretion rate of Levofloxacin which could result in a lower serum level and potentially a reduction in efficacy.
Meperidine Injection Meperidine Injection Eplerenone may increase the excretion rate of Meperidine which could result in a lower serum level and potentially a reduction in efficacy.
Metoclopramide Injection Metoclopramide Injection Eplerenone may increase the excretion rate of Metoclopramide which could result in a lower serum level and potentially a reduction in efficacy.
Metronidazole Injection Metronidazole Injection The metabolism of Metronidazole can be decreased when combined with Eplerenone.
Morphine Injection Morphine Injection The therapeutic efficacy of Eplerenone can be decreased when used in combination with Morphine.
Vancomycin Injection Vancomycin Injection Eplerenone may increase the excretion rate of Vancomycin which could result in a lower serum level and potentially a reduction in efficacy.
Altretamine Altretamine Amphetamine may increase the orthostatic hypotensive activities of Eplerenone.
Cyclosporine Cyclosporine The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Cyclosporine.
Ondansetron Ondansetron The metabolism of Ondansetron can be decreased when combined with Eplerenone.
Enoxaparin Injection Enoxaparin Injection The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Enoxaparin.
Torsemide Torsemide Torasemide may increase the hypotensive activities of Eplerenone.
Olanzapine Olanzapine The risk or severity of adverse effects can be increased when Olanzapine is combined with Eplerenone.
Eprosartan Eprosartan The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Eprosartan.
Meloxicam Meloxicam The therapeutic efficacy of Eplerenone can be decreased when used in combination with Meloxicam.
Oxcarbazepine Oxcarbazepine The metabolism of Eplerenone can be increased when combined with Oxcarbazepine.
Pantoprazole Pantoprazole Eplerenone may increase the excretion rate of Pantoprazole which could result in a lower serum level and potentially a reduction in efficacy.
Telmisartan Telmisartan The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Telmisartan.
Temozolomide Temozolomide Eplerenone may increase the excretion rate of Temozolomide which could result in a lower serum level and potentially a reduction in efficacy.
Zaleplon Zaleplon Eplerenone may increase the excretion rate of Zaleplon which could result in a lower serum level and potentially a reduction in efficacy.
Anakinra Anakinra The metabolism of Eplerenone can be increased when combined with Anakinra.
Linezolid Linezolid Linezolid may increase the orthostatic hypotensive activities of Eplerenone.
Trimipramine Trimipramine Trimipramine may decrease the antihypertensive activities of Eplerenone.
Etanercept Injection Etanercept Injection The metabolism of Eplerenone can be increased when combined with Etanercept.
Modafinil Modafinil The metabolism of Eplerenone can be increased when combined with Modafinil.
Perindopril Perindopril Eplerenone may increase the hyperkalemic activities of Perindopril.
Tenofovir Tenofovir Eplerenone may increase the excretion rate of Tenofovir which could result in a lower serum level and potentially a reduction in efficacy.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Choline magnesium trisalicylate is combined with Eplerenone.
Sirolimus Sirolimus The metabolism of Sirolimus can be decreased when combined with Eplerenone.
Dutasteride Dutasteride The metabolism of Dutasteride can be decreased when combined with Eplerenone.
Epinephrine Injection Epinephrine Injection The risk or severity of Cardiac Arrhythmia can be increased when Epinephrine is combined with Eplerenone.
Olmesartan Olmesartan The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Olmesartan.
Zonisamide Zonisamide Eplerenone may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Adalimumab Injection Adalimumab Injection The metabolism of Eplerenone can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The risk or severity of hypotension can be increased when Aripiprazole is combined with Eplerenone.
Atomoxetine Atomoxetine Eplerenone may increase the excretion rate of Atomoxetine which could result in a lower serum level and potentially a reduction in efficacy.
Dexmethylphenidate Dexmethylphenidate Dexmethylphenidate may decrease the antihypertensive activities of Eplerenone.
Atazanavir Atazanavir The metabolism of Eplerenone can be decreased when combined with Atazanavir.
Almotriptan Almotriptan Almotriptan may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Eletriptan Eletriptan Eletriptan may decrease the antihypertensive activities of Eplerenone.
Polyethylene Glycol 3350 Polyethylene Glycol 3350 The risk or severity of adverse effects can be increased when Eplerenone is combined with Polyethylene glycol.
Rosuvastatin Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Eplerenone.
Vardenafil Vardenafil Eplerenone may increase the antihypertensive activities of Vardenafil.
Alfuzosin Alfuzosin Alfuzosin may increase the hypotensive activities of Eplerenone.
Aprepitant Aprepitant The metabolism of Eplerenone can be decreased when combined with Aprepitant.
Emtricitabine Emtricitabine Eplerenone may increase the excretion rate of Emtricitabine which could result in a lower serum level and potentially a reduction in efficacy.
Memantine Memantine Eplerenone may increase the excretion rate of Memantine which could result in a lower serum level and potentially a reduction in efficacy.
Tegaserod Tegaserod The risk or severity of adverse effects can be increased when Eplerenone is combined with Tegaserod.
Tadalafil Tadalafil Eplerenone may increase the excretion rate of Tadalafil which could result in a lower serum level and potentially a reduction in efficacy.
Frovatriptan Frovatriptan Frovatriptan may decrease the antihypertensive activities of Eplerenone.
Progesterone Progesterone The metabolism of Eplerenone can be decreased when combined with Progesterone.
Apomorphine Injection Apomorphine Injection The risk or severity of adverse effects can be increased when Apomorphine is combined with Eplerenone.
Infliximab Injection Infliximab Injection The metabolism of Eplerenone can be increased when combined with Infliximab.
Protriptyline Protriptyline Protriptyline may decrease the antihypertensive activities of Eplerenone.
Duloxetine Duloxetine The risk or severity of orthostatic hypotension and syncope can be increased when Eplerenone is combined with Duloxetine.
Norethindrone Norethindrone The metabolism of Norethisterone can be decreased when combined with Eplerenone.
Tinidazole Tinidazole Eplerenone may increase the excretion rate of Tinidazole which could result in a lower serum level and potentially a reduction in efficacy.
Bosentan Bosentan Bosentan may increase the hypotensive activities of Eplerenone.
Cefditoren Cefditoren Eplerenone may increase the excretion rate of Cefdinir which could result in a lower serum level and potentially a reduction in efficacy.
Cyanocobalamin Injection Cyanocobalamin Injection Eplerenone may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
Erlotinib Erlotinib The metabolism of Eplerenone can be decreased when combined with Erlotinib.
Eszopiclone Eszopiclone Eplerenone may increase the excretion rate of Eszopiclone which could result in a lower serum level and potentially a reduction in efficacy.
Ganciclovir Ganciclovir Eplerenone may increase the excretion rate of Ganciclovir which could result in a lower serum level and potentially a reduction in efficacy.
Ribavirin Ribavirin Eplerenone may increase the excretion rate of Ribavirin which could result in a lower serum level and potentially a reduction in efficacy.
Solifenacin Solifenacin Solifenacin may decrease the antihypertensive activities of Eplerenone.
Valganciclovir Valganciclovir Eplerenone may increase the excretion rate of Valganciclovir which could result in a lower serum level and potentially a reduction in efficacy.
Voriconazole Voriconazole The metabolism of Eplerenone can be decreased when combined with Voriconazole.
Dextroamphetamine Dextroamphetamine Amphetamine may increase the orthostatic hypotensive activities of Eplerenone.
Isocarboxazid Isocarboxazid Isocarboxazid may increase the orthostatic hypotensive activities of Eplerenone.
Ramelteon Ramelteon Eplerenone may increase the excretion rate of Ramelteon which could result in a lower serum level and potentially a reduction in efficacy.
Fentanyl Fentanyl Fentanyl may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Pregabalin Pregabalin Eplerenone may increase the excretion rate of Pregabalin which could result in a lower serum level and potentially a reduction in efficacy.
Phenylephrine Phenylephrine Phenylephrine may decrease the antihypertensive activities of Eplerenone.
Tipranavir Tipranavir The metabolism of Tipranavir can be decreased when combined with Eplerenone.
Ranolazine Ranolazine Eplerenone may increase the excretion rate of Ranolazine which could result in a lower serum level and potentially a reduction in efficacy.
Abatacept Injection Abatacept Injection The metabolism of Eplerenone can be increased when combined with Abatacept.
Rasagiline Rasagiline Rasagiline may increase the orthostatic hypotensive activities of Eplerenone.
Imatinib Imatinib The metabolism of Eplerenone can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin Eplerenone may increase the excretion rate of Sitagliptin which could result in a lower serum level and potentially a reduction in efficacy.
Varenicline Varenicline Eplerenone may increase the excretion rate of Varenicline which could result in a lower serum level and potentially a reduction in efficacy.
Gefitinib Gefitinib The metabolism of Eplerenone can be decreased when combined with Gefitinib.
Albuterol Albuterol Salbutamol may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Paliperidone Paliperidone Eplerenone may increase the excretion rate of Paliperidone which could result in a lower serum level and potentially a reduction in efficacy.
Clofarabine Injection Clofarabine Injection Clofarabine may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Lubiprostone Lubiprostone The risk or severity of adverse effects can be increased when Eplerenone is combined with Lubiprostone.
Posaconazole Posaconazole The metabolism of Eplerenone can be decreased when combined with Posaconazole.
Primaquine Primaquine The metabolism of Eplerenone can be decreased when combined with Primaquine.
Rituximab Injection Rituximab Injection Eplerenone may increase the hypotensive activities of Rituximab.
Aliskiren Aliskiren The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Aliskiren.
Darunavir Darunavir The metabolism of Darunavir can be decreased when combined with Eplerenone.
Pemetrexed Injection Pemetrexed Injection Eplerenone may increase the excretion rate of Pemetrexed which could result in a lower serum level and potentially a reduction in efficacy.
Lisdexamfetamine Lisdexamfetamine Lisdexamfetamine may decrease the antihypertensive activities of Eplerenone.
Nabilone Nabilone The risk or severity of adverse effects can be increased when Nabilone is combined with Eplerenone.
Sorafenib Sorafenib The metabolism of Eplerenone can be decreased when combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Sunitinib can be decreased when combined with Eplerenone.
Lapatinib Lapatinib The metabolism of Lapatinib can be decreased when combined with Eplerenone.
Levocetirizine Levocetirizine Eplerenone may increase the excretion rate of Levocetirizine which could result in a lower serum level and potentially a reduction in efficacy.
Pegaptanib Injection Pegaptanib Injection Eplerenone may increase the excretion rate of Pegaptanib which could result in a lower serum level and potentially a reduction in efficacy.
Dasatinib Dasatinib The metabolism of Dasatinib can be decreased when combined with Eplerenone.
Armodafinil Armodafinil The metabolism of Eplerenone can be increased when combined with Armodafinil.
Azacitidine Injection Azacitidine Injection Eplerenone may increase the excretion rate of Azacitidine which could result in a lower serum level and potentially a reduction in efficacy.
Paclitaxel (with polyoxyethylated castor oil) Injection Paclitaxel (with polyoxyethylated castor oil) Injection The risk or severity of adverse effects can be increased when Eplerenone is combined with Castor oil.
Temsirolimus Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Eplerenone.
Lenalidomide Lenalidomide Eplerenone may increase the excretion rate of Lenalidomide which could result in a lower serum level and potentially a reduction in efficacy.
Nilotinib Nilotinib The metabolism of Eplerenone can be decreased when combined with Nilotinib.
Budesonide Budesonide The metabolism of Eplerenone can be increased when combined with Budesonide.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Eplerenone can be decreased when combined with Chloramphenicol.
Desmopressin Desmopressin Eplerenone may increase the excretion rate of Desmopressin which could result in a lower serum level and potentially a reduction in efficacy.
Doripenem Injection Doripenem Injection Eplerenone may increase the excretion rate of Doripenem which could result in a lower serum level and potentially a reduction in efficacy.
Arsenic Trioxide Injection Arsenic Trioxide Injection Arsenic trioxide may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Desvenlafaxine Desvenlafaxine The metabolism of Eplerenone can be decreased when combined with Desvenlafaxine.
Cevimeline Cevimeline Eplerenone may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
Nebivolol Nebivolol The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Nebivolol.
Tretinoin Tretinoin The metabolism of Tretinoin can be decreased when combined with Eplerenone.
Certolizumab Injection Certolizumab Injection The metabolism of Eplerenone can be increased when combined with Certolizumab pegol.
Irinotecan Injection Irinotecan Injection The metabolism of Irinotecan can be decreased when combined with Eplerenone.
Daptomycin Injection Daptomycin Injection Eplerenone may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy.
Praziquantel Praziquantel The metabolism of Praziquantel can be decreased when combined with Eplerenone.
Methylnaltrexone Injection Methylnaltrexone Injection Eplerenone may increase the excretion rate of Methylnaltrexone which could result in a lower serum level and potentially a reduction in efficacy.
Midazolam Midazolam Midazolam may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Naltrexone Injection Naltrexone Injection The therapeutic efficacy of Eplerenone can be decreased when used in combination with Naltrexone.
Dexrazoxane Injection Dexrazoxane Injection Eplerenone may increase the excretion rate of Dexrazoxane which could result in a lower serum level and potentially a reduction in efficacy.
Milnacipran Milnacipran The metabolism of Eplerenone can be decreased when combined with Milnacipran.
Plerixafor Injection Plerixafor Injection Eplerenone may increase the excretion rate of Plerixafor which could result in a lower serum level and potentially a reduction in efficacy.
Sodium Phosphate Sodium Phosphate Eplerenone may increase the nephrotoxic activities of Sodium phosphate, monobasic.
Fesoterodine Fesoterodine Eplerenone may increase the excretion rate of Fesoterodine which could result in a lower serum level and potentially a reduction in efficacy.
Betaxolol Betaxolol The risk or severity of hyperkalemia can be increased when Betaxolol is combined with Eplerenone.
Iloperidone Iloperidone The metabolism of Iloperidone can be decreased when combined with Eplerenone.
Prasugrel Prasugrel Eplerenone may increase the excretion rate of Prasugrel which could result in a lower serum level and potentially a reduction in efficacy.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Tolvaptan.
Dronedarone Dronedarone The metabolism of Dronedarone can be decreased when combined with Eplerenone.
Pralatrexate Injection Pralatrexate Injection Eplerenone may increase the excretion rate of Pralatrexate which could result in a lower serum level and potentially a reduction in efficacy.
Palonosetron Injection Palonosetron Injection Eplerenone may increase the excretion rate of Palonosetron which could result in a lower serum level and potentially a reduction in efficacy.
Saxagliptin Saxagliptin Eplerenone may increase the excretion rate of Saxagliptin which could result in a lower serum level and potentially a reduction in efficacy.
Telavancin Injection Telavancin Injection Eplerenone may increase the excretion rate of Telavancin which could result in a lower serum level and potentially a reduction in efficacy.
Romidepsin Injection Romidepsin Injection The metabolism of Romidepsin can be decreased when combined with Eplerenone.
Tapentadol Tapentadol The therapeutic efficacy of Eplerenone can be decreased when used in combination with Tapentadol.
Topotecan Topotecan Eplerenone may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Golimumab Injection Golimumab Injection The metabolism of Eplerenone can be increased when combined with Golimumab.
Asenapine Asenapine Asenapine may decrease the antihypertensive activities of Eplerenone.
Levonorgestrel Levonorgestrel The metabolism of Eplerenone can be decreased when combined with Levonorgestrel.
Oxymorphone Oxymorphone The therapeutic efficacy of Eplerenone can be decreased when used in combination with Oxymorphone.
Tocilizumab Injection Tocilizumab Injection The metabolism of Eplerenone can be increased when combined with Tocilizumab.
Dalfampridine Dalfampridine Eplerenone may increase the excretion rate of Dalfampridine which could result in a lower serum level and potentially a reduction in efficacy.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Cabazitaxel can be decreased when combined with Eplerenone.
Lurasidone Lurasidone Lurasidone may decrease the antihypertensive activities of Eplerenone.
Acetaminophen Injection Acetaminophen Injection Eplerenone may increase the excretion rate of Acetaminophen which could result in a lower serum level and potentially a reduction in efficacy.
Vilazodone Vilazodone Vilazodone may decrease the antihypertensive activities of Eplerenone.
Ipilimumab Injection Ipilimumab Injection Eplerenone may increase the excretion rate of Ipilimumab which could result in a lower serum level and potentially a reduction in efficacy.
Denileukin Diftitox Injection Denileukin Diftitox Injection Aldesleukin may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Terbutaline Injection Terbutaline Injection Eplerenone may increase the excretion rate of Terbutaline which could result in a lower serum level and potentially a reduction in efficacy.
Azilsartan Azilsartan The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Azilsartan medoxomil.
Roflumilast Roflumilast Eplerenone may increase the excretion rate of Roflumilast which could result in a lower serum level and potentially a reduction in efficacy.
Linagliptin Linagliptin The metabolism of Eplerenone can be decreased when combined with Linagliptin.
Potassium Iodide Potassium Iodide The risk or severity of hyperkalemia can be increased when Potassium Iodide is combined with Eplerenone.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Eplerenone can be decreased when combined with Cyclophosphamide.
Rivaroxaban Rivaroxaban Eplerenone may increase the excretion rate of Rivaroxaban which could result in a lower serum level and potentially a reduction in efficacy.
Ruxolitinib Ruxolitinib Eplerenone may increase the excretion rate of Ruxolitinib which could result in a lower serum level and potentially a reduction in efficacy.
Clobazam Clobazam Eplerenone may increase the excretion rate of Clobazam which could result in a lower serum level and potentially a reduction in efficacy.
Ivacaftor Ivacaftor The metabolism of Ivacaftor can be decreased when combined with Eplerenone.
Deferiprone Deferiprone Eplerenone may increase the excretion rate of Deferiprone which could result in a lower serum level and potentially a reduction in efficacy.
Axitinib Axitinib The metabolism of Axitinib can be decreased when combined with Eplerenone.
Crizotinib Crizotinib The metabolism of Eplerenone can be decreased when combined with Crizotinib.
Cabergoline Cabergoline Cabergoline may decrease the antihypertensive activities of Eplerenone.
Naloxone Injection Naloxone Injection The metabolism of Eplerenone can be decreased when combined with Naloxone.
Ambrisentan Ambrisentan The metabolism of Ambrisentan can be decreased when combined with Eplerenone.
Fondaparinux Injection Fondaparinux Injection Eplerenone may increase the excretion rate of Fondaparinux which could result in a lower serum level and potentially a reduction in efficacy.
Iloprost Iloprost Iloprost may increase the hypotensive activities of Eplerenone.
Enzalutamide Enzalutamide Eplerenone may increase the excretion rate of Enzalutamide which could result in a lower serum level and potentially a reduction in efficacy.
Mirabegron Mirabegron Mirabegron may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Linaclotide Linaclotide The risk or severity of adverse effects can be increased when Eplerenone is combined with Linaclotide.
Teduglutide Injection Teduglutide Injection Eplerenone may increase the excretion rate of Teduglutide which could result in a lower serum level and potentially a reduction in efficacy.
Alogliptin Alogliptin Eplerenone may increase the excretion rate of Alogliptin which could result in a lower serum level and potentially a reduction in efficacy.
Ponatinib Ponatinib The metabolism of Ponatinib can be decreased when combined with Eplerenone.
Pomalidomide Pomalidomide Eplerenone may increase the excretion rate of Pomalidomide which could result in a lower serum level and potentially a reduction in efficacy.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be decreased when combined with Eplerenone.
Apixaban Apixaban The metabolism of Apixaban can be decreased when combined with Eplerenone.
Canagliflozin Canagliflozin Canagliflozin may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Methazolamide Methazolamide The risk or severity of adverse effects can be increased when Methazolamide is combined with Eplerenone.
Trametinib Trametinib Eplerenone may increase the excretion rate of Trametinib which could result in a lower serum level and potentially a reduction in efficacy.
Levomilnacipran Levomilnacipran Eplerenone may increase the excretion rate of Levomilnacipran which could result in a lower serum level and potentially a reduction in efficacy.
Ertapenem Injection Ertapenem Injection Eplerenone may increase the excretion rate of Ertapenem which could result in a lower serum level and potentially a reduction in efficacy.
Vortioxetine Vortioxetine Eplerenone may increase the excretion rate of Vortioxetine which could result in a lower serum level and potentially a reduction in efficacy.
Perampanel Perampanel The metabolism of Perampanel can be decreased when combined with Eplerenone.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Eplerenone.
Avanafil Avanafil Avanafil may increase the antihypertensive activities of Eplerenone.
Ketorolac Injection Ketorolac Injection The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Ketorolac is combined with Eplerenone.
Obinutuzumab Injection Obinutuzumab Injection Eplerenone may increase the hypotensive activities of Obinutuzumab.
Simeprevir Simeprevir The metabolism of Eplerenone can be decreased when combined with Simeprevir.
Sofosbuvir Sofosbuvir Eplerenone may increase the excretion rate of Sofosbuvir which could result in a lower serum level and potentially a reduction in efficacy.
Dapagliflozin Dapagliflozin The risk or severity of adverse effects can be increased when Dapagliflozin is combined with Eplerenone.
Apremilast Apremilast The metabolism of Eplerenone can be increased when combined with Apremilast.
Droxidopa Droxidopa The risk or severity of Cardiac Arrhythmia can be increased when Droxidopa is combined with Eplerenone.
Siltuximab Injection Siltuximab Injection The metabolism of Eplerenone can be increased when combined with Siltuximab.
Testosterone Injection Testosterone Injection Testosterone may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Empagliflozin Empagliflozin Empagliflozin may increase the diuretic activities of Eplerenone.
Hydrocodone Hydrocodone The therapeutic efficacy of Eplerenone can be decreased when used in combination with Hydrocodone.
Edoxaban Edoxaban Eplerenone may increase the excretion rate of Edoxaban which could result in a lower serum level and potentially a reduction in efficacy.
Olaparib Olaparib The metabolism of Olaparib can be decreased when combined with Eplerenone.
Methamphetamine Methamphetamine Eplerenone may increase the excretion rate of Metamfetamine which could result in a lower serum level and potentially a reduction in efficacy.
Tasimelteon Tasimelteon Eplerenone may increase the excretion rate of Tasimelteon which could result in a lower serum level and potentially a reduction in efficacy.
Riociguat Riociguat Eplerenone may increase the hypotensive activities of Riociguat.
Secukinumab Injection Secukinumab Injection The metabolism of Eplerenone can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection Eplerenone may increase the hypotensive activities of Risperidone.
Dinutuximab Injection Dinutuximab Injection The risk or severity of adverse effects can be increased when Dinutuximab is combined with Eplerenone.
Haloperidol Injection Haloperidol Injection The metabolism of Eplerenone can be decreased when combined with Haloperidol.
Amiloride Amiloride The risk or severity of hyperkalemia can be increased when Amiloride is combined with Eplerenone.
Isavuconazonium Injection Isavuconazonium Injection The metabolism of Eplerenone can be decreased when combined with Isavuconazonium.
Macitentan Macitentan Eplerenone may increase the excretion rate of Macitentan which could result in a lower serum level and potentially a reduction in efficacy.
Flibanserin Flibanserin Flibanserin may decrease the antihypertensive activities of Eplerenone.
Daclatasvir Daclatasvir The metabolism of Daclatasvir can be decreased when combined with Eplerenone.
Brexpiprazole Brexpiprazole Brexpiprazole may decrease the antihypertensive activities of Eplerenone.
Ziprasidone Injection Ziprasidone Injection The metabolism of Eplerenone can be decreased when combined with Ziprasidone.
Cariprazine Cariprazine Cariprazine may decrease the antihypertensive activities of Eplerenone.
Penicillin G Procaine Injection Penicillin G Procaine Injection Eplerenone may increase the excretion rate of Procaine benzylpenicillin which could result in a lower serum level and potentially a reduction in efficacy.
Eluxadoline Eluxadoline The therapeutic efficacy of Eplerenone can be decreased when used in combination with Eluxadoline.
Ixazomib Ixazomib Eplerenone may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
Lesinurad Lesinurad Eplerenone may increase the excretion rate of Lesinurad which could result in a lower serum level and potentially a reduction in efficacy.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The risk or severity of adverse effects can be increased when Amphotericin B is combined with Eplerenone.
Dexamethasone Injection Dexamethasone Injection The metabolism of Eplerenone can be increased when combined with Dexamethasone.
Brivaracetam Injection Brivaracetam Injection Eplerenone may increase the excretion rate of Brivaracetam which could result in a lower serum level and potentially a reduction in efficacy.
Venetoclax Venetoclax The metabolism of Eplerenone can be decreased when combined with Venetoclax.
Cobicistat Cobicistat The metabolism of Eplerenone can be decreased when combined with Cobicistat.
Midodrine Midodrine Midodrine may decrease the antihypertensive activities of Eplerenone.
Selexipag Selexipag Eplerenone may increase the hypotensive activities of Selexipag.
Furosemide Injection Furosemide Injection Furosemide may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Rucaparib Rucaparib The metabolism of Eplerenone can be decreased when combined with Rucaparib.
Lixisenatide Injection Lixisenatide Injection Eplerenone may increase the excretion rate of Lixisenatide which could result in a lower serum level and potentially a reduction in efficacy.
Ribociclib Ribociclib The metabolism of Eplerenone can be decreased when combined with Ribociclib.
Doxepin (Insomnia) Doxepin (Insomnia) Doxepin may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Plecanatide Plecanatide The risk or severity of adverse effects can be increased when Eplerenone is combined with Plecanatide.
Deutetrabenazine Deutetrabenazine Eplerenone may increase the excretion rate of Deutetrabenazine which could result in a lower serum level and potentially a reduction in efficacy.
Valbenazine Valbenazine Eplerenone may increase the excretion rate of Valbenazine which could result in a lower serum level and potentially a reduction in efficacy.
Deflazacort Deflazacort The metabolism of Eplerenone can be increased when combined with Deflazacort.
Safinamide Safinamide The metabolism of Eplerenone can be decreased when combined with Safinamide.
Naldemedine Naldemedine Eplerenone may increase the excretion rate of Naldemedine which could result in a lower serum level and potentially a reduction in efficacy.
Midostaurin Midostaurin The metabolism of Eplerenone can be decreased when combined with Midostaurin.
Benznidazole Benznidazole Eplerenone may increase the excretion rate of Benznidazole which could result in a lower serum level and potentially a reduction in efficacy.
Copanlisib Injection Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Eplerenone.
Delafloxacin Delafloxacin Eplerenone may increase the excretion rate of Delafloxacin which could result in a lower serum level and potentially a reduction in efficacy.
Acalabrutinib Acalabrutinib The metabolism of Eplerenone can be decreased when combined with Acalabrutinib.
Letermovir Letermovir The metabolism of Eplerenone can be decreased when combined with Letermovir.
Buprenorphine Injection Buprenorphine Injection The therapeutic efficacy of Buprenorphine can be decreased when used in combination with Eplerenone.
Apalutamide Apalutamide Eplerenone may increase the excretion rate of Apalutamide which could result in a lower serum level and potentially a reduction in efficacy.
Fostamatinib Fostamatinib Fostamatinib may increase the antihypertensive activities of Eplerenone.
Baricitinib Baricitinib Eplerenone may increase the excretion rate of Baricitinib which could result in a lower serum level and potentially a reduction in efficacy.
Lofexidine Lofexidine Eplerenone may increase the excretion rate of Lofexidine which could result in a lower serum level and potentially a reduction in efficacy.
Plazomicin Injection Plazomicin Injection Eplerenone may increase the excretion rate of Plazomicin which could result in a lower serum level and potentially a reduction in efficacy.
Doravirine Doravirine The metabolism of Doravirine can be decreased when combined with Eplerenone.
Cannabidiol Cannabidiol The metabolism of Eplerenone can be decreased when combined with Cannabidiol.
Stiripentol Stiripentol The metabolism of Eplerenone can be decreased when combined with Stiripentol.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Eplerenone.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Eplerenone.
Prucalopride Prucalopride The risk or severity of adverse effects can be increased when Eplerenone is combined with Prucalopride.
Magnesium Citrate Magnesium Citrate The risk or severity of adverse effects can be increased when Eplerenone is combined with Magnesium citrate.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Eplerenone can be increased when combined with Emapalumab.
Siponimod Siponimod Siponimod may decrease the antihypertensive activities of Eplerenone.
Acyclovir Ophthalmic Acyclovir Ophthalmic Eplerenone may increase the excretion rate of Acyclovir which could result in a lower serum level and potentially a reduction in efficacy.
Solriamfetol Solriamfetol Eplerenone may increase the excretion rate of Solriamfetol which could result in a lower serum level and potentially a reduction in efficacy.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Eplerenone.
Pitolisant Pitolisant The serum concentration of Eplerenone can be decreased when it is combined with Pitolisant.
Phenytoin Injection Phenytoin Injection The metabolism of Eplerenone can be increased when combined with Phenytoin.
Cenobamate Cenobamate The serum concentration of Eplerenone can be decreased when it is combined with Cenobamate.
Selumetinib Selumetinib The metabolism of Selumetinib can be decreased when combined with Eplerenone.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Eplerenone.
Selpercatinib Selpercatinib Selpercatinib may decrease the antihypertensive activities of Eplerenone.
Lemborexant Lemborexant The metabolism of Lemborexant can be decreased when combined with Eplerenone.
Pralsetinib Pralsetinib The metabolism of Eplerenone can be decreased when combined with Pralsetinib.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Eplerenone can be decreased when it is combined with Satralizumab.
Naxitamab-gqgk Injection Naxitamab-gqgk Injection Naxitamab may decrease the antihypertensive activities of Eplerenone.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The risk or severity of hyperkalemia can be increased when Drospirenone is combined with Eplerenone.
Viloxazine Viloxazine Eplerenone may increase the excretion rate of Viloxazine which could result in a lower serum level and potentially a reduction in efficacy.
Fenoprofen Fenoprofen The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Fenoprofen is combined with Eplerenone.
Indomethacin Indomethacin The therapeutic efficacy of Eplerenone can be decreased when used in combination with Indomethacin.
Mefenamic Acid Mefenamic Acid The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Mefenamic acid is combined with Eplerenone.
Naproxen Naproxen The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Naproxen is combined with Eplerenone.
Tolmetin Tolmetin The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Tolmetin is combined with Eplerenone.
Sulindac Sulindac The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Sulindac is combined with Eplerenone.
Trazodone Trazodone The metabolism of Eplerenone can be decreased when combined with Trazodone.
Isotretinoin Isotretinoin Eplerenone may increase the excretion rate of Isotretinoin which could result in a lower serum level and potentially a reduction in efficacy.
Sucralfate Sucralfate Eplerenone may increase the excretion rate of Sucralfate which could result in a lower serum level and potentially a reduction in efficacy.
Floxuridine Floxuridine Eplerenone may increase the excretion rate of Floxuridine which could result in a lower serum level and potentially a reduction in efficacy.
Phenobarbital Phenobarbital The metabolism of Eplerenone can be increased when combined with Phenobarbital.
Metaxalone Metaxalone Eplerenone may increase the excretion rate of Metaxalone which could result in a lower serum level and potentially a reduction in efficacy.
Methotrexate Injection Methotrexate Injection Eplerenone may increase the excretion rate of Methotrexate which could result in a lower serum level and potentially a reduction in efficacy.
Levorphanol Levorphanol The therapeutic efficacy of Eplerenone can be decreased when used in combination with Levorphanol.
Primidone Primidone Primidone may increase the hypotensive activities of Eplerenone.
Methsuximide Methsuximide The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Methsuximide.
Diethylpropion Diethylpropion Diethylpropion may decrease the antihypertensive activities of Eplerenone.
Chlorpromazine Chlorpromazine Chlorpromazine may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Diazepam Diazepam Eplerenone may increase the excretion rate of Diazepam which could result in a lower serum level and potentially a reduction in efficacy.
Oxazepam Oxazepam Eplerenone may increase the excretion rate of Oxazepam which could result in a lower serum level and potentially a reduction in efficacy.
Flurazepam Flurazepam Eplerenone may increase the excretion rate of Flurazepam which could result in a lower serum level and potentially a reduction in efficacy.
Clorazepate Clorazepate Eplerenone may increase the excretion rate of Clorazepic acid which could result in a lower serum level and potentially a reduction in efficacy.
Lorazepam Lorazepam Eplerenone may increase the excretion rate of Lorazepam which could result in a lower serum level and potentially a reduction in efficacy.
Phenoxybenzamine Phenoxybenzamine Eplerenone may decrease the antihypertensive activities of Phenoxybenzamine.
Carmustine Carmustine Eplerenone may increase the excretion rate of Carmustine which could result in a lower serum level and potentially a reduction in efficacy.
Amantadine Amantadine Eplerenone may increase the excretion rate of Amantadine which could result in a lower serum level and potentially a reduction in efficacy.
Codeine Codeine Eplerenone may increase the excretion rate of Codeine which could result in a lower serum level and potentially a reduction in efficacy.
Bromocriptine Bromocriptine Bromocriptine may decrease the antihypertensive activities of Eplerenone.
Metaproterenol Metaproterenol Orciprenaline may decrease the antihypertensive activities of Eplerenone.
Tranylcypromine Tranylcypromine Tranylcypromine may increase the hypotensive activities of Eplerenone.
Phenelzine Phenelzine Phenelzine may increase the hypotensive activities of Eplerenone.
Procarbazine Procarbazine Procarbazine may increase the orthostatic hypotensive activities of Eplerenone.
Ergoloid Mesylates Ergoloid Mesylates Ergoloid mesylate may decrease the antihypertensive activities of Eplerenone.
Tetracycline Tetracycline Eplerenone may increase the excretion rate of Tetracycline which could result in a lower serum level and potentially a reduction in efficacy.
Thioridazine Thioridazine Thioridazine may decrease the antihypertensive activities of Eplerenone.
Trifluoperazine Trifluoperazine Trifluoperazine may decrease the antihypertensive activities of Eplerenone.
Bleomycin Bleomycin Eplerenone may increase the excretion rate of Bleomycin which could result in a lower serum level and potentially a reduction in efficacy.
Dapsone Dapsone The metabolism of Eplerenone can be decreased when combined with Dapsone.
Sulfadiazine Sulfadiazine Eplerenone may increase the excretion rate of Sulfadiazine which could result in a lower serum level and potentially a reduction in efficacy.
Oxycodone Oxycodone The therapeutic efficacy of Eplerenone can be decreased when used in combination with Oxycodone.
Methadone Methadone Methadone may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Oxybutynin Oxybutynin The metabolism of Oxybutynin can be decreased when combined with Eplerenone.
Benztropine Benztropine Eplerenone may increase the excretion rate of Benzatropine which could result in a lower serum level and potentially a reduction in efficacy.
Maprotiline Maprotiline Eplerenone may increase the excretion rate of Maprotiline which could result in a lower serum level and potentially a reduction in efficacy.
Ibuprofen Ibuprofen The therapeutic efficacy of Eplerenone can be decreased when used in combination with Ibuprofen.
Azathioprine Azathioprine Eplerenone may increase the excretion rate of Azathioprine which could result in a lower serum level and potentially a reduction in efficacy.
Phentermine Phentermine Phentermine may decrease the antihypertensive activities of Eplerenone.
Methylphenidate Methylphenidate Methylphenidate may decrease the antihypertensive activities of Eplerenone.
Amoxapine Amoxapine Amoxapine may decrease the antihypertensive activities of Eplerenone.
Sulfasalazine Sulfasalazine The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Sulfasalazine is combined with Eplerenone.
Hydrocortisone Hydrocortisone The metabolism of Hydrocortisone can be decreased when combined with Eplerenone.
Phenazopyridine Phenazopyridine Eplerenone may increase the excretion rate of Phenazopyridine which could result in a lower serum level and potentially a reduction in efficacy.
Carbamazepine Carbamazepine The metabolism of Carbamazepine can be decreased when combined with Eplerenone.
Methyldopa Methyldopa Eplerenone may increase the excretion rate of Methyldopa which could result in a lower serum level and potentially a reduction in efficacy.
Clonidine Clonidine The risk or severity of hypotension can be increased when Clonidine is combined with Eplerenone.
Prazosin Prazosin The risk or severity of hypotension can be increased when Prazosin is combined with Eplerenone.
Hydralazine Hydralazine Eplerenone may increase the excretion rate of Hydralazine which could result in a lower serum level and potentially a reduction in efficacy.
Cimetidine Cimetidine The metabolism of Eplerenone can be decreased when combined with Cimetidine.
Warfarin Warfarin Eplerenone may increase the excretion rate of Warfarin which could result in a lower serum level and potentially a reduction in efficacy.
Clonazepam Clonazepam Eplerenone may increase the excretion rate of Clonazepam which could result in a lower serum level and potentially a reduction in efficacy.
Loperamide Loperamide The metabolism of Eplerenone can be decreased when combined with Loperamide.
Promethazine Promethazine Eplerenone may increase the excretion rate of Promethazine which could result in a lower serum level and potentially a reduction in efficacy.
Meclofenamate Meclofenamate The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Meclofenamic acid is combined with Eplerenone.
Daunorubicin Daunorubicin The metabolism of Eplerenone can be increased when combined with Daunorubicin.
Nitrofurantoin Nitrofurantoin Nitrofurantoin may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Digoxin Digoxin Eplerenone may decrease the excretion rate of Digoxin which could result in a higher serum level.
Chloroquine Chloroquine Chloroquine may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Quinine Quinine Quinine may increase the hypotensive activities of Eplerenone.
Ethosuximide Ethosuximide The risk or severity of hyperkalemia can be increased when Ethosuximide is combined with Eplerenone.
Triamterene Triamterene The risk or severity of hyperkalemia can be increased when Triamterene is combined with Eplerenone.
Lactulose Lactulose The risk or severity of adverse effects can be increased when Eplerenone is combined with Lactulose.
Chlorothiazide Chlorothiazide The therapeutic efficacy of Chlorothiazide can be increased when used in combination with Eplerenone.
Chlorthalidone Chlorthalidone Chlorthalidone may increase the hypotensive activities of Eplerenone.
Metolazone Metolazone Metolazone may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Clindamycin Injection Clindamycin Injection The metabolism of Clindamycin can be decreased when combined with Eplerenone.
Secobarbital Secobarbital Secobarbital may increase the hypotensive activities of Eplerenone.
Desipramine Desipramine Desipramine may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Amitriptyline Amitriptyline Amitriptyline may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Imipramine Imipramine Imipramine may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Probenecid Probenecid Eplerenone may increase the excretion rate of Probenecid which could result in a lower serum level and potentially a reduction in efficacy.
Quinidine Quinidine The metabolism of Eplerenone can be decreased when combined with Quinidine.
Procainamide Procainamide Eplerenone may increase the excretion rate of Procainamide which could result in a lower serum level and potentially a reduction in efficacy.
Isoniazid Isoniazid The metabolism of Eplerenone can be decreased when combined with Isoniazid.
Pyrazinamide Pyrazinamide Eplerenone may increase the excretion rate of Pyrazinamide which could result in a lower serum level and potentially a reduction in efficacy.
Rifampin Rifampin The metabolism of Eplerenone can be increased when combined with Rifampicin.
Disopyramide Disopyramide Eplerenone may increase the excretion rate of Disopyramide which could result in a lower serum level and potentially a reduction in efficacy.
Tamoxifen Tamoxifen The metabolism of Eplerenone can be decreased when combined with Tamoxifen.
Butabarbital Butabarbital Eplerenone may increase the excretion rate of Butabarbital which could result in a lower serum level and potentially a reduction in efficacy.
Liothyronine Liothyronine Eplerenone may increase the excretion rate of Liothyronine which could result in a lower serum level and potentially a reduction in efficacy.
Methimazole Methimazole The metabolism of Methimazole can be decreased when combined with Eplerenone.
Chlorpropamide Chlorpropamide Eplerenone may increase the excretion rate of Chlorpropamide which could result in a lower serum level and potentially a reduction in efficacy.
Tolbutamide Tolbutamide Eplerenone may increase the excretion rate of Tolbutamide which could result in a lower serum level and potentially a reduction in efficacy.
Tolazamide Tolazamide Eplerenone may increase the excretion rate of Tolazamide which could result in a lower serum level and potentially a reduction in efficacy.
Dextromethorphan Dextromethorphan The metabolism of Eplerenone can be decreased when combined with Dextromethorphan.
Baclofen Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Eplerenone.
Chlorpheniramine Chlorpheniramine The metabolism of Chlorpheniramine can be decreased when combined with Eplerenone.
Ethambutol Ethambutol Eplerenone may increase the excretion rate of Ethambutol which could result in a lower serum level and potentially a reduction in efficacy.
Methyclothiazide Methyclothiazide The therapeutic efficacy of Eplerenone can be increased when used in combination with Methyclothiazide.
Hydrochlorothiazide Hydrochlorothiazide The therapeutic efficacy of Hydrochlorothiazide can be increased when used in combination with Eplerenone.
Dantrolene Dantrolene The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Dantrolene.
Chlorzoxazone Chlorzoxazone Eplerenone may increase the excretion rate of Chlorzoxazone which could result in a lower serum level and potentially a reduction in efficacy.
Pyridoxine Pyridoxine Eplerenone may increase the excretion rate of Pyridoxine which could result in a lower serum level and potentially a reduction in efficacy.
Folic Acid Folic Acid Eplerenone may increase the excretion rate of Folic acid which could result in a lower serum level and potentially a reduction in efficacy.
Danazol Danazol The metabolism of Eplerenone can be decreased when combined with Danazol.
Disulfiram Disulfiram The metabolism of Disulfiram can be decreased when combined with Eplerenone.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) Propranolol may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Minoxidil Minoxidil Minoxidil may increase the hypotensive activities of Eplerenone.
Pseudoephedrine Pseudoephedrine Pseudoephedrine may decrease the antihypertensive activities of Eplerenone.
Nortriptyline Nortriptyline Nortriptyline may decrease the antihypertensive activities of Eplerenone.
Spironolactone Spironolactone The risk or severity of hyperkalemia can be increased when Spironolactone is combined with Eplerenone.
Amphotericin B Injection Amphotericin B Injection The risk or severity of adverse effects can be increased when Amphotericin B is combined with Eplerenone.
Phytonadione Phytonadione Eplerenone may increase the excretion rate of Phylloquinone which could result in a lower serum level and potentially a reduction in efficacy.
Nadolol Nadolol Eplerenone may increase the excretion rate of Nadolol which could result in a lower serum level and potentially a reduction in efficacy.
Butorphanol Injection Butorphanol Injection The therapeutic efficacy of Eplerenone can be decreased when used in combination with Butorphanol.
Nalbuphine Injection Nalbuphine Injection The therapeutic efficacy of Eplerenone can be decreased when used in combination with Nalbuphine.
Allopurinol Allopurinol Eplerenone may increase the excretion rate of Allopurinol which could result in a lower serum level and potentially a reduction in efficacy.
Flavoxate Flavoxate Eplerenone may increase the excretion rate of Flavoxate which could result in a lower serum level and potentially a reduction in efficacy.
Papaverine Papaverine The risk or severity of adverse effects can be increased when Papaverine is combined with Eplerenone.
Colchicine Colchicine Eplerenone may increase the excretion rate of Colchicine which could result in a lower serum level and potentially a reduction in efficacy.
Cefaclor Cefaclor Eplerenone may increase the excretion rate of Cefaclor which could result in a lower serum level and potentially a reduction in efficacy.
Cefadroxil Cefadroxil Eplerenone may increase the excretion rate of Cefadroxil which could result in a lower serum level and potentially a reduction in efficacy.
Cephalexin Cephalexin Eplerenone may increase the excretion rate of Cephalexin which could result in a lower serum level and potentially a reduction in efficacy.
Dacarbazine Dacarbazine Eplerenone may increase the excretion rate of Dacarbazine which could result in a lower serum level and potentially a reduction in efficacy.
Calcitonin Salmon Injection Calcitonin Salmon Injection Eplerenone may increase the excretion rate of Salmon calcitonin which could result in a lower serum level and potentially a reduction in efficacy.
Ketoconazole Ketoconazole The metabolism of Eplerenone can be decreased when combined with Ketoconazole.
Pyrantel Pyrantel Eplerenone may increase the excretion rate of Pyrantel which could result in a lower serum level and potentially a reduction in efficacy.
Vincristine Injection Vincristine Injection The metabolism of Eplerenone can be decreased when combined with Vincristine.
Captopril Captopril Eplerenone may increase the hyperkalemic activities of Captopril.
Dipyridamole Dipyridamole Dipyridamole may increase the antihypertensive activities of Eplerenone.
Isoxsuprine Isoxsuprine Isoxsuprine may decrease the antihypertensive activities of Eplerenone.
Ethacrynic Acid Ethacrynic Acid The risk or severity of adverse effects can be increased when Etacrynic acid is combined with Eplerenone.
Metoprolol Metoprolol Metoprolol may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Hydroxyzine Hydroxyzine The metabolism of Eplerenone can be decreased when combined with Hydroxyzine.
Aspirin Aspirin Acetylsalicylic acid may decrease the excretion rate of Eplerenone which could result in a higher serum level.
Salsalate Salsalate The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Salsalate is combined with Eplerenone.
Alprazolam Alprazolam Alprazolam may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Temazepam Temazepam Eplerenone may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
Triazolam Triazolam Eplerenone may increase the excretion rate of Triazolam which could result in a lower serum level and potentially a reduction in efficacy.
Dicyclomine Dicyclomine Eplerenone may increase the excretion rate of Dicyclomine which could result in a lower serum level and potentially a reduction in efficacy.
Propantheline Propantheline Eplerenone may increase the excretion rate of Propantheline which could result in a lower serum level and potentially a reduction in efficacy.
Trimethoprim Trimethoprim Eplerenone may increase the excretion rate of Trimethoprim which could result in a lower serum level and potentially a reduction in efficacy.
Diltiazem Diltiazem The metabolism of Eplerenone can be decreased when combined with Diltiazem.
Nifedipine Nifedipine Nifedipine may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Timolol Timolol Timolol may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Verapamil Verapamil The metabolism of Eplerenone can be decreased when combined with Verapamil.
Atenolol Atenolol The risk or severity of hyperkalemia can be increased when Atenolol is combined with Eplerenone.
Pindolol Pindolol Eplerenone may increase the excretion rate of Pindolol which could result in a lower serum level and potentially a reduction in efficacy.
Cisplatin Injection Cisplatin Injection Eplerenone may increase the excretion rate of Cisplatin which could result in a lower serum level and potentially a reduction in efficacy.
Diflunisal Diflunisal The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Diflunisal is combined with Eplerenone.
Piroxicam Piroxicam The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Piroxicam is combined with Eplerenone.
Bumetanide Bumetanide Bumetanide may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Etoposide Etoposide The metabolism of Etoposide can be decreased when combined with Eplerenone.
Glyburide Glyburide The metabolism of Glyburide can be decreased when combined with Eplerenone.
Glipizide Glipizide Eplerenone may increase the excretion rate of Glipizide which could result in a lower serum level and potentially a reduction in efficacy.
Indapamide Indapamide The therapeutic efficacy of Indapamide can be increased when used in combination with Eplerenone.
Amoxicillin Amoxicillin Eplerenone may increase the excretion rate of Amoxicillin which could result in a lower serum level and potentially a reduction in efficacy.
Oxacillin Injection Oxacillin Injection Eplerenone may increase the excretion rate of Oxacillin which could result in a lower serum level and potentially a reduction in efficacy.
Pentoxifylline Pentoxifylline Pentoxifylline may increase the hypotensive activities of Eplerenone.
Pentamidine Injection Pentamidine Injection The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Pentamidine.
Ceftriaxone Injection Ceftriaxone Injection Eplerenone may increase the excretion rate of Ceftriaxone which could result in a lower serum level and potentially a reduction in efficacy.
Labetalol Labetalol Labetalol may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Auranofin Auranofin Eplerenone may increase the excretion rate of Auranofin which could result in a lower serum level and potentially a reduction in efficacy.
Leuprolide Injection Leuprolide Injection Eplerenone may increase the excretion rate of Leuprolide which could result in a lower serum level and potentially a reduction in efficacy.
Gemfibrozil Gemfibrozil Eplerenone may increase the excretion rate of Gemfibrozil which could result in a lower serum level and potentially a reduction in efficacy.
Guanabenz Guanabenz Eplerenone may decrease the antihypertensive activities of Guanabenz.
Ceftazidime Injection Ceftazidime Injection Eplerenone may increase the excretion rate of Ceftazidime which could result in a lower serum level and potentially a reduction in efficacy.
Ketoprofen Ketoprofen The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Ketoprofen is combined with Eplerenone.
Cefotetan Injection Cefotetan Injection Eplerenone may increase the excretion rate of Cefotetan which could result in a lower serum level and potentially a reduction in efficacy.
Pimozide Pimozide The metabolism of Pimozide can be decreased when combined with Eplerenone.
Enalapril Enalapril Eplerenone may increase the hyperkalemic activities of Enalapril.
Flurbiprofen Flurbiprofen The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Flurbiprofen is combined with Eplerenone.
Amiodarone Amiodarone The risk or severity of adverse effects can be increased when Amiodarone is combined with Eplerenone.
Aztreonam Injection Aztreonam Injection Eplerenone may increase the excretion rate of Aztreonam which could result in a lower serum level and potentially a reduction in efficacy.
Buspirone Buspirone Buspirone may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Lovastatin Lovastatin The metabolism of Eplerenone can be decreased when combined with Lovastatin.
Ciprofloxacin Ciprofloxacin The metabolism of Eplerenone can be decreased when combined with Ciprofloxacin.
Mesalamine Mesalamine The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Mesalazine is combined with Eplerenone.
Diclofenac Diclofenac The therapeutic efficacy of Eplerenone can be decreased when used in combination with Diclofenac.
Nimodipine Nimodipine The risk or severity of hyperkalemia can be increased when Nimodipine is combined with Eplerenone.
Clozapine Clozapine The metabolism of Eplerenone can be decreased when combined with Clozapine.
Estazolam Estazolam Eplerenone may increase the excretion rate of Estazolam which could result in a lower serum level and potentially a reduction in efficacy.
Didanosine Didanosine Eplerenone may increase the excretion rate of Didanosine which could result in a lower serum level and potentially a reduction in efficacy.
Pentostatin Injection Pentostatin Injection Eplerenone may increase the excretion rate of Pentostatin which could result in a lower serum level and potentially a reduction in efficacy.
Clarithromycin Clarithromycin The metabolism of Eplerenone can be decreased when combined with Clarithromycin.
Benazepril Benazepril Eplerenone may increase the hyperkalemic activities of Benazepril.
Etodolac Etodolac The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Etodolac is combined with Eplerenone.
Felodipine Felodipine Eplerenone may increase the hypotensive activities of Felodipine.
Fosinopril Fosinopril Eplerenone may increase the hyperkalemic activities of Fosinopril.
Nabumetone Nabumetone The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Nabumetone is combined with Eplerenone.
Quinapril Quinapril Eplerenone may increase the hyperkalemic activities of Quinapril.
Ramipril Ramipril Eplerenone may increase the hyperkalemic activities of Ramipril.
Simvastatin Simvastatin The metabolism of Eplerenone can be decreased when combined with Simvastatin.
Amlodipine Amlodipine The risk or severity of hyperkalemia can be increased when Amlodipine is combined with Eplerenone.
Teniposide Injection Teniposide Injection The metabolism of Eplerenone can be decreased when combined with Teniposide.
Itraconazole Itraconazole The metabolism of Eplerenone can be decreased when combined with Itraconazole.
Lisinopril Lisinopril Eplerenone may increase the hyperkalemic activities of Lisinopril.
Oxaprozin Oxaprozin The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Oxaprozin is combined with Eplerenone.
Sotalol Sotalol The risk or severity of hyperkalemia can be increased when Sotalol is combined with Eplerenone.
Bisoprolol Bisoprolol Bisoprolol may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Doxazosin Doxazosin Doxazosin may increase the hypotensive activities of Eplerenone.
Terazosin Terazosin Eplerenone may increase the hypotensive activities of Terazosin.
Isradipine Isradipine The metabolism of Eplerenone can be decreased when combined with Isradipine.
Cisapride Cisapride The metabolism of Eplerenone can be decreased when combined with Cisapride.
Fluvastatin Fluvastatin The metabolism of Fluvastatin can be decreased when combined with Eplerenone.
Venlafaxine Venlafaxine Eplerenone may increase the excretion rate of Venlafaxine which could result in a lower serum level and potentially a reduction in efficacy.
Fluvoxamine Fluvoxamine The metabolism of Eplerenone can be decreased when combined with Fluvoxamine.
Nefazodone Nefazodone The metabolism of Eplerenone can be decreased when combined with Nefazodone.
Lamotrigine Lamotrigine Lamotrigine may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Losartan Losartan The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Losartan.
Valacyclovir Valacyclovir Eplerenone may increase the excretion rate of Valaciclovir which could result in a lower serum level and potentially a reduction in efficacy.
Tramadol Tramadol Eplerenone may increase the excretion rate of Tramadol which could result in a lower serum level and potentially a reduction in efficacy.
Carboplatin Injection Carboplatin Injection Eplerenone may increase the excretion rate of Carboplatin which could result in a lower serum level and potentially a reduction in efficacy.
Moexipril Moexipril Eplerenone may increase the hyperkalemic activities of Moexipril.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ifosfamide can be decreased when combined with Eplerenone.
Nicardipine Nicardipine The metabolism of Eplerenone can be decreased when combined with Nicardipine.
Bupropion Bupropion Eplerenone may increase the excretion rate of Bupropion which could result in a lower serum level and potentially a reduction in efficacy.
Ticlopidine Ticlopidine Eplerenone may increase the excretion rate of Ticlopidine which could result in a lower serum level and potentially a reduction in efficacy.
Saquinavir Saquinavir The metabolism of Saquinavir can be decreased when combined with Eplerenone.
Metformin Metformin Eplerenone may increase the excretion rate of Metformin which could result in a lower serum level and potentially a reduction in efficacy.
Dalteparin Injection Dalteparin Injection The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Dalteparin.
Nisoldipine Nisoldipine Nisoldipine may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Lamivudine Lamivudine Eplerenone may increase the excretion rate of Lamivudine which could result in a lower serum level and potentially a reduction in efficacy.
Amifostine Injection Amifostine Injection Eplerenone may increase the hypotensive activities of Amifostine.
Acarbose Acarbose Eplerenone may increase the excretion rate of Acarbose which could result in a lower serum level and potentially a reduction in efficacy.
Gemcitabine Injection Gemcitabine Injection Eplerenone may increase the excretion rate of Gemcitabine which could result in a lower serum level and potentially a reduction in efficacy.
Indinavir Indinavir The metabolism of Eplerenone can be decreased when combined with Indinavir.
Ritonavir Ritonavir The metabolism of Eplerenone can be decreased when combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Docetaxel can be decreased when combined with Eplerenone.
Cidofovir Injection Cidofovir Injection Eplerenone may increase the excretion rate of Cidofovir which could result in a lower serum level and potentially a reduction in efficacy.
Meropenem Injection Meropenem Injection Eplerenone may increase the excretion rate of Meropenem which could result in a lower serum level and potentially a reduction in efficacy.
Clomipramine Clomipramine Clomipramine may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Fosfomycin Fosfomycin Eplerenone may increase the excretion rate of Fosfomycin which could result in a lower serum level and potentially a reduction in efficacy.
Mirtazapine Mirtazapine Mirtazapine may decrease the antihypertensive activities of Eplerenone.
Trandolapril Trandolapril Eplerenone may increase the hyperkalemic activities of Trandolapril.
Topiramate Topiramate Eplerenone may increase the excretion rate of Topiramate which could result in a lower serum level and potentially a reduction in efficacy.
Valsartan Valsartan The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Valsartan.
Pramipexole Pramipexole Pramipexole may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Nelfinavir Nelfinavir The metabolism of Eplerenone can be decreased when combined with Nelfinavir.
Carvedilol Carvedilol The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Carvedilol.
Nilutamide Nilutamide Eplerenone may increase the excretion rate of Nilutamide which could result in a lower serum level and potentially a reduction in efficacy.
Flutamide Flutamide Flutamide may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Selegiline Selegiline Selegiline may increase the hypotensive activities of Eplerenone.
Propafenone Propafenone The risk or severity of hyperkalemia can be increased when Propafenone is combined with Eplerenone.
Irbesartan Irbesartan The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Irbesartan.
Tamsulosin Tamsulosin Tamsulosin may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Ropinirole Ropinirole The risk or severity of adverse effects can be increased when Ropinirole is combined with Eplerenone.
Finasteride Finasteride The metabolism of Finasteride can be decreased when combined with Eplerenone.
Quetiapine Quetiapine Eplerenone may increase the hypotensive activities of Quetiapine.
Cetirizine Cetirizine Eplerenone may increase the excretion rate of Cetirizine which could result in a lower serum level and potentially a reduction in efficacy.
Tolcapone Tolcapone Tolcapone may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Capecitabine Capecitabine Eplerenone may increase the excretion rate of Capecitabine which could result in a lower serum level and potentially a reduction in efficacy.
Efavirenz Efavirenz The metabolism of Eplerenone can be decreased when combined with Efavirenz.
Abacavir Abacavir Eplerenone may increase the excretion rate of Abacavir which could result in a lower serum level and potentially a reduction in efficacy.
Sildenafil Sildenafil Sildenafil may increase the antihypertensive activities of Eplerenone.
Celecoxib Celecoxib The therapeutic efficacy of Eplerenone can be decreased when used in combination with Celecoxib.
Rosiglitazone Rosiglitazone Eplerenone may increase the excretion rate of Rosiglitazone which could result in a lower serum level and potentially a reduction in efficacy.
Tolterodine Tolterodine Eplerenone may increase the excretion rate of Tolterodine which could result in a lower serum level and potentially a reduction in efficacy.
Thalidomide Thalidomide The metabolism of Eplerenone can be increased when combined with Thalidomide.
Oseltamivir Oseltamivir Eplerenone may increase the excretion rate of Oseltamivir which could result in a lower serum level and potentially a reduction in efficacy.
Balsalazide Balsalazide The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Balsalazide is combined with Eplerenone.
Nateglinide Nateglinide Eplerenone may increase the excretion rate of Nateglinide which could result in a lower serum level and potentially a reduction in efficacy.
Rabeprazole Rabeprazole Eplerenone may increase the excretion rate of Rabeprazole which could result in a lower serum level and potentially a reduction in efficacy.

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