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Lansoprazole

Lansoprazole is a proton pump inhibitor (acid reducer) used to treat stomach and duodenal ulcers, GERD, erosive esophagitis and other acid-related conditions, and in some over-the-counter capsules and tablets, frequent heartburn.

Brand names PrevacidPrevacid 24HRPrevacid SoluTabbasic care lansoprazoleGood Sense Lansoprazole +11 more
Drug class Proton Pump Inhibitor
Rx/OTC Forms 3
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026 Content updated Oct 2, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 116 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

✓No current FDA shortage listed · checked Oct 4, 2026
Lansoprazole at a glance The quick version — the full detail is in the Patient Information Guide below.
Dr. Brian Staiger, PharmD, BCPS
The Pharmacist’s Take By · Clinical pharmacist · Written

Lansoprazole (Prevacid) is a proton pump inhibitor, an acid reducer that blocks the stomach's acid pumps, used for ulcers, acid reflux (GERD), acid damage to the esophagus and, over the counter, frequent heartburn. On the market since the mid-1990s and available as a generic, it is a standard first choice. Most people tolerate it well, and mild diarrhea, nausea or belly pain are the usual complaints. Watch for diarrhea that will not settle, which can signal C. difficile, a serious gut infection. Use it for the shortest time that works, and get checked if heartburn keeps coming back, since relief does not rule out stomach cancer.

Clinical pearls

  • Take it before a meal, ideally before breakfast, because food lowers how much of the dose gets absorbed.
  • Never combine it with rilpivirine HIV medicines, and expect extra INR blood checks if you also take warfarin.
  • After years of daily use, ask about checking vitamin B12 and magnesium levels and about your bone health.
  • Tell anyone ordering a urine drug screen or neuroendocrine tumor tests that you take it, since results can be misleading.
How we write & review this content — our editorial policy →
How you get itPrescription and over the counter
Comes asDelayed-release capsule, Delayed-release orally disintegrating tablet, Orally disintegrating tablet
Earliest FDA record1995
Companies listing it with the FDA60
FDA label last updatedJul 8, 2025
FDA’s strongest warning (boxed)None on the label

Patient information guide A plain-language walkthrough of Lansoprazole, written from its FDA label.

What Lansoprazole is used for

▾

Lansoprazole is used for several acid-related conditions. Uses vary by product.

  • Active duodenal ulcer (short-term treatment) in adults, in prescription products
  • Clearing H. pylori infection to lower the chance of duodenal ulcer coming back, together with amoxicillin, with or without clarithromycin, in adults
  • Keeping healed duodenal ulcers healed in adults
  • Active benign gastric (stomach) ulcer in adults
  • Healing stomach ulcers linked to NSAID pain relievers, and lowering the risk of them in adults with a past stomach ulcer, in prescription capsules
  • Symptomatic GERD in adults and children 1 year and older
  • Erosive esophagitis in adults and children 1 year and older, and keeping it healed in adults
  • Conditions with too much stomach acid, including Zollinger-Ellison syndrome, in adults
  • Frequent heartburn (2 or more days a week) in adults, in over-the-counter products such as Prevacid 24 HR

How Lansoprazole works

▾

Lansoprazole is a proton pump inhibitor. It blocks the “acid pump” (the H+, K+-ATPase enzyme) on stomach lining cells, the final step in making acid. This lowers both resting and meal-triggered acid.

Its effect on acid lasts more than 24 hours, even though the drug leaves your blood much faster.

Lansoprazole dosage

▾

Lansoprazole is taken by mouth, generally once a day, and works best when taken before meals. Follow your prescriber and label for how long to take it.

  • Capsules (including Prevacid) are swallowed whole.
  • Prevacid SoluTab and other orally disintegrating tablets are placed on the tongue to dissolve and are not chewed, broken or cut.
  • Over-the-counter heartburn products are taken once a day for 14 days, and courses can be repeated every 4 months at most unless a doctor directs otherwise.
  • With sucralfate, take lansoprazole at least 30 minutes before it.

Dosing details from the FDA-approved label

From the Lansoprazole prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.

  • Duodenal Ulcers Short-Term Treatment (adult)
    • 15 mg once daily for 4 weeks
  • Duodenal Ulcers Maintenance of Healed (adult)
    • 15 mg once daily
  • Eradication of H. pylori to Reduce the Risk of Duodenal Ulcer Recurrence (adult)
    • Triple Therapy: lansoprazole 30 mg twice daily, amoxicillin 1 gram twice daily, clarithromycin 500 mg twice daily, each for 10 or 14 days
    • Dual Therapy: lansoprazole 30 mg three times daily and amoxicillin 1 gram three times daily, each for 14 days
    • Refer to amoxicillin and clarithromycin prescribing information for dosing in elderly and renally-impaired patients
  • Benign Gastric Ulcer Short-Term Treatment (adult)
    • 30 mg once daily for up to 8 weeks
  • NSAID-Associated Gastric Ulcer (adult)
    • Healing: 30 mg once daily for 8 weeks
    • Risk Reduction: 15 mg once daily for up to 12 weeks
    • Controlled studies did not extend beyond indicated duration
  • GERD (adult): Symptomatic GERD and Erosive Esophagitis
    • Symptomatic GERD: 15 mg once daily for up to 8 weeks
    • Erosive esophagitis short-term: 30 mg once daily for up to 8 weeks
    • Maintenance of healing of erosive esophagitis: 15 mg once daily
    • If not healed after eight weeks (5 to 10%), an additional eight weeks may be helpful; controlled maintenance studies did not extend beyond 12 months
  • Pathological Hypersecretory Conditions Including Zollinger-Ellison Syndrome (adult)
    • 60 mg once daily starting dose
    • Adjust to individual patient needs and continue as long as clinically indicated
    • Dosages up to 90 mg twice daily have been administered
    • Maximum: Daily dose of greater than 120 mg should be administered in divided doses
    • Varies with individual patient
  • Pediatric patients 1 to 11 years: Symptomatic GERD and Erosive Esophagitis
    • ≤30 kg: 15 mg once daily for up to 12 weeks
    • >30 kg: 30 mg once daily for up to 12 weeks
    • Do not exceed recommended dose and duration; not given beyond 12 weeks in studies
  • Pediatric patients 12 to 17 years: Symptomatic GERD
    • Non-erosive GERD: 15 mg once daily for up to 8 weeks
    • Erosive Esophagitis: 30 mg once daily for up to 8 weeks
  • Severe hepatic impairment (Child-Pugh C)
    • 15 mg orally daily
    • Severe liver impairment
Read the label’s full dosing text

2 DOSAGE AND ADMINISTRATION Recommended Dosage : See full prescribing information for complete dosing information for PREVACID and PREVACID SoluTab by indication and age group and dosage adjustment in patients with severe hepatic impairment. ( 2.1 , 2.2 , 2.3 ) Administration Instructions ( 2.4 ) PREVACID capsules Should be swallowed whole. See full prescribing information for alternative administration options. PREVACID SoluTab Should not be broken or cut. Should not be chewed. Place the tablet on the tongue and allow it to disintegrate, with or without water, until the particles can be swallowed. See full prescribing information for alternative administration options. 2.1 Recommended Adult Dosage by Indication Indication Recommended Dose Frequency Duodenal Ulcers Short-Term Treatment 15 mg Once daily for 4 weeks Maintenance of Healed 15 mg Once daily Eradication of H. pylori to Reduce the Risk of Duodenal Ulcer Recurrence Please refer to the amoxicillin and clarithromycin full prescribing information, Contraindications and Warnings and Precautions sections, and for information regarding dosing in elderly and renally-impaired patients. Triple Therapy: PREVACID or PREVACID SoluTab 30 mg Twice daily for 10 or 14 days Amoxicillin 1 gram Twice daily for 10 or 14 days Clarithromycin 500 mg Twice daily for 10 or 14 days Dual Therapy: PREVACID or PREVACID SoluTab 30 mg Three times daily for 14 days Amoxicillin 1 gram Three times daily for 14 days Benign Gastric Ulcer Short-Term Treatment 30 mg Once daily for up to 8 weeks NSAID-Associated Gastric Ulcer Healing 30 mg Once daily for 8 weeks Controlled studies did not extend beyond indicated duration. Risk Reduction 15 mg Once daily for up to 12 weeks Gastroesophageal Reflux Disease (GERD) Short-Term Treatment of Symptomatic GERD 15 mg Once daily for up to 8 weeks Short-Term Treatment of Erosive Esophagitis 30 mg Once daily for up to 8 weeks For patients who do not heal with PREVACID or PREVACID SoluTab for eight weeks (5 to 10%), it may be helpful to give an additional eight weeks of treatment. If there is a recurrence of erosive esophagitis, an additional eight week course of PREVACID or PREVACID SoluTab may be considered. Maintenance of Healing of Erosive Esophagitis 15 mg Once daily Controlled studies did not extend beyond 12 months.

Excerpted — the section continues on the label. Read the full Dosage and Administration section on DailyMed →

Lansoprazole side effects

▾

Most people tolerate lansoprazole well. Common side effects include:

Common side effects

  • Diarrhea
  • Abdominal (belly) pain
  • Nausea
  • Constipation
  • Headache (when taken with antibiotics for H. pylori)
  • Taste changes (when taken with antibiotics for H. pylori)

When to get medical help

  • Severe skin reactions such as blistering, peeling or widespread rash, or signs of an allergic reaction (swelling, trouble breathing, hives). Stop the medicine and get medical help.
  • Diarrhea that does not get better, which may be a Clostridium difficile infection.
  • Signs of kidney problems, such as feeling unwell, nausea, loss of appetite or less urine.
  • New or worsening rash, especially on sun-exposed skin, or joint pain, which could be lupus.
  • Muscle spasms, irregular heartbeat or seizures, which may signal low magnesium.
  • Symptoms that return quickly or do not improve, since acid reducers do not rule out stomach cancer.

Lansoprazole warnings and precautions

▾
  • Possible hidden problems: Feeling better does not rule out stomach cancer. Tell your doctor if symptoms return soon or do not improve.
  • Serious reactions: Kidney inflammation, severe skin reactions, and lupus have been reported. Stop the medicine and get help if these are suspected.
  • C. difficile diarrhea: Diarrhea that does not improve needs evaluation.
  • Long-term use: May raise the risk of bone fractures, low vitamin B12, low magnesium, and fundic gland polyps.
  • Lab tests: Can cause false results on neuroendocrine tumor tests, and false positive urine THC screens.
  • Infants: Not recommended under 1 year of age.

Lansoprazole interactions

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Lansoprazole can change the effects of other medicines. Tell your pharmacist about everything you take.

  • Rilpivirine HIV medicines: must not be combined.
  • Nelfinavir, atazanavir, saquinavir: levels can change.
  • Warfarin: may raise bleeding risk, so INR monitoring is needed.
  • Methotrexate: levels may rise, especially with high doses.
  • Digoxin, tacrolimus, theophylline: levels may need monitoring.
  • Iron, ketoconazole, itraconazole, erlotinib, dasatinib, nilotinib, mycophenolate: absorption may drop with less stomach acid.
  • St John’s Wort and rifampin: reduce lansoprazole levels and should be avoided.
  • Sucralfate: take lansoprazole at least 30 minutes earlier.

Interactions listed in the FDA-approved label

From the Lansoprazole prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.

  • Rilpivirine-containing products: Decreased exposure of rilpivirine may reduce antiviral effect and promote drug resistance. Concomitant use is contraindicated.
  • Atazanavir: Decreased exposure of atazanavir may reduce antiviral effect and promote drug resistance. See prescribing information for atazanavir for dosing information.
  • Nelfinavir: Decreased exposure of nelfinavir may reduce antiviral effect and promote drug resistance. Avoid concomitant use.
  • Saquinavir: Increased exposure of saquinavir may increase its toxicity. Monitor for potential saquinavir toxicities; see prescribing information.
  • Warfarin: Increased INR and prothrombin time, which may lead to abnormal bleeding and even death. Monitor INR and prothrombin time; warfarin dose adjustment may be needed.
  • Methotrexate: May elevate and prolong serum concentrations of methotrexate and/or hydroxymethotrexate, possibly leading to methotrexate toxicities. A temporary withdrawal of lansoprazole may be considered in some patients receiving high-dose methotrexate.
  • Digoxin: Potential for increased exposure of digoxin. Monitor digoxin concentrations; dose adjustment may be needed.
  • Theophylline: Increased clearance of theophylline. Individual patients may require additional titration of theophylline dosage when lansoprazole is started or stopped.
  • Tacrolimus: Potentially increased exposure of tacrolimus, especially in transplant patients who are intermediate or poor CYP2C19 metabolizers. Monitor tacrolimus whole blood trough concentrations; dose adjustment may be needed.
  • Sucralfate: Decreased and delayed absorption of lansoprazole. Take lansoprazole at least 30 minutes prior to sucralfate.
Read the label’s full interactions text

7 DRUG INTERACTIONS Tables 2 and 3 include drugs with clinically important drug interactions and interaction with diagnostics when administered concomitantly with lansoprazole delayed-release orally disintegrating tablets and instructions for preventing or managing them. Consult the labeling of concomitantly used drugs to obtain further information about interactions with PPIs. Table 2. Clinically Relevant Interactions Affecting Drugs Coadministered with Lansoprazole Delayed-Release Orally Disintegrating Tablets and Interactions with Diagnostics Antiretrovirals C li n i ca l I mpact: The effect of PPIs on antiretroviral drugs is variable. The clinical importance and the mechanisms behind these interactions are not always known. •Decreased exposure of some antiretroviral drugs (e.g., rilpivirine, atazanavir, and nelfinavir) when used concomitantly with lansoprazole may reduce antiviral effect and promote the development of drug resistance. •Increased exposure of other antiretroviral drugs (e.g., saquinavir) when used concomitantly with lansoprazole may increase toxicity of the antiretroviral drugs. •There are other antiretroviral drugs which do not result in clinically relevant interactions with lansoprazole I nte rv ent i on : Rilpivirine-containing products: Concomitant use with lansoprazole delayed-release orally disintegrating tablets are contraindicated [ see Contra i nd i cat i ons ( 4 ) ]. See prescribing information. Atazanavir: See prescribing information for atazanavir for dosing information. Nelfinavir: Avoid concomitant use with lansoprazole delayed-release orally disintegrating tablets. See prescribing information for nelfinavir. Saquinavir: See the prescribing information for saquinavir and monitor for potential saquinavir toxicities. Other antiretrovirals: See prescribing information. Warfarin C li n i ca l Impact: Increased INR and prothrombin time in patients receiving PPIs and warfarin concomitantly.

Excerpted — the section continues on the label. Read the full Drug Interactions section on DailyMed →

Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.

🌿153 supplements and herbs with documented Lansoprazole interactions, ranked by severity Check Lansoprazole against a supplement or herb →

Before taking Lansoprazole

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  • Do not take it if you are allergic to lansoprazole or any ingredient, or if you take rilpivirine.
  • Tell your doctor if you are pregnant or planning pregnancy, or breastfeeding.
  • Tell your doctor if you have PKU, since the orally disintegrating tablets contain phenylalanine.
  • Children: prescription use is for GERD and erosive esophagitis in ages 1 and older. Children under 18 should ask a doctor before over-the-counter use.
  • Older adults clear lansoprazole more slowly, and an endoscopy may be considered if symptoms persist.
  • Tell your doctor if you have low magnesium or calcium, or take diuretics or digoxin.
  • Severe liver problems may call for dose adjustment.

Lansoprazole overdose

▾

In one reported overdose, a patient took 600 mg with no adverse reaction. Lansoprazole is not removed by hemodialysis. Treatment is symptomatic and supportive. If you think too much was taken, call poison control at 1-800-222-1222.

What Lansoprazole does in the body

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Lansoprazole raises stomach pH (makes it less acidic) and lowers acid output, including after meals. Acid suppression begins within hours and builds with daily dosing. Acid levels return to normal over 2 to 4 days after stopping, with no rebound acidity. Gastrin levels rise but return to baseline within about four weeks of stopping.

How your body processes Lansoprazole

▾

Lansoprazole capsules contain coated pellets, so absorption starts only after they leave the stomach. Blood levels peak at about 1.7 hours. Taking it 30 minutes after food reduces absorption by about 50 to 70%.

It is broken down extensively in the liver. The half-life in the blood is under 2 hours, yet acid suppression lasts over 24 hours. Clearance is slower in older adults. Metabolites leave mostly in the feces, with about one-third in the urine.

How to store Lansoprazole

▾

Store at 20°–25° C (68°–77° F); .

Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

153

Supplements & herbs that interact with Lansoprazole

153 supplements and herbal products have documented interactions with Lansoprazole in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 3
  • Moderate · 101
  • Minor · 49
ACTIVATED CHARCOAL Major GRAPEFRUIT Major ST. JOHN'S WORT Major ACACIA RIGIDULA Moderate ADRAFINIL Moderate AFRICAN WILD POTATO Moderate AMERICAN ELDER Moderate ARTICHOKE Moderate +145 more
Every supplement checked against Lansoprazole — ranked by severity The full interaction hub: 3 major · 101 moderate · 49 minor · every one linked to its full report. Check Lansoprazole against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

9

Nutrient depletion considerations

Lansoprazole has been associated with lower levels of 9 nutrients in the clinical literature. This does not mean a deficiency will occur — it means these may be worth discussing with your pharmacist or healthcare provider, especially with long-term use.

Evidence & significance mix
  • Higher significance · 5
  • Moderate · 1
  • Unrated · 3
CALCIUM Insignificant Depletion FOLIC ACID Insignificant Depletion IRON Insignificant Depletion MAGNESIUM Major Depletion ZINC Insignificant Depletion VITAMIN B12 Moderate Depletion BETA-CAROTENE Insufficient Evidence CHROMIUM Insufficient Evidence +1 more
See the full Lansoprazole nutrient depletion report

Educational information from a licensed clinical database (Natural Medicines) — not medical advice. Do not start or stop medications or supplements without professional guidance.

Lansoprazole: pharmacist answers to common questions

Quick, plain-English answers to the questions patients ask most about Lansoprazole — the kind of thing our pharmacy team would talk through with you at the counter.

What is lansoprazole for?

▾
It lowers stomach acid. Prescription forms treat ulcers, GERD, erosive esophagitis and conditions with too much acid. It is also used with antibiotics for H. pylori. Over-the-counter versions treat frequent heartburn.

When and how should I take it?

▾
Take it once a day, before eating, usually in the morning. Swallow capsules whole. Let orally disintegrating tablets dissolve on your tongue without chewing. For over-the-counter use, stop after 14 days unless your doctor says otherwise.

How fast will it work?

▾
For heartburn, the over-the-counter label says full effect can take 1 to 4 days, though some people feel relief within 24 hours. It is not meant for instant relief.

What side effects should I expect?

▾
The most common are diarrhea, belly pain, nausea and constipation. Call your doctor if you get a severe rash, swelling, trouble breathing, diarrhea that will not clear, or muscle spasms or an irregular heartbeat.

Can I take it with my other medicines?

▾
Many medicines interact with it, including warfarin, methotrexate, digoxin, HIV drugs, and St John’s Wort. It must not be taken with rilpivirine. Always let me know everything you take so we can check.

Is it safe to use for a long time or in pregnancy?

▾
Longer use can raise the risk of fractures, low B12 and low magnesium, so use the lowest dose for the shortest time that works. Human studies have not shown pregnancy problems, but animal studies showed effects on fetal bone growth. Talk to your doctor if you are pregnant or planning to be.

Is Lansoprazole available over the counter?

▾
Both. Some Lansoprazole products are sold over the counter and others need a prescription. According to their FDA listings, the delayed-release capsule and delayed-release orally disintegrating tablet forms are sold both ways, at different strengths or package sizes and the orally disintegrating tablet form needs a prescription. The package says which kind you have. Your pharmacist can tell you which product is right for you.

When was Lansoprazole first available?

▾
The earliest FDA record we hold for Lansoprazole is from 1995: its first approval in Drugs@FDA or its earliest product listing in the NDC Directory, whichever is older. Many older medicines were in use before their first formal FDA approval, so this is the earliest date on record, not necessarily when Lansoprazole was first used.

Who makes Lansoprazole?

▾
60 companies currently list Lansoprazole products in the FDA's NDC Directory, including Bryant Ranch Prepack, NuCare Pharmaceuticals,Inc., A-S Medication Solutions. That count includes repackagers and distributors as well as manufacturers (companies that sell only the raw ingredient are not counted), so fewer companies actually make it; the label on your bottle names the one that supplied yours.

Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

More about Lansoprazole on HelloPharmacist

📊Lansoprazole supplement interactions153 checked — ranked by severity 🌿Drug & Supplement CheckerLansoprazole vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Lansoprazole NDCs & costs 🅰️Browse Drugs A–ZLook up any medication
Detailed data & references for Lansoprazole Forms & strengths, pricing, billing codes, manufacturers, safety reports and sourcing — the data behind the page. Most people can stop here. Each section below opens on a tap.

Lansoprazole forms and strengths (how it comes)

Lansoprazole is available in 3 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Delayed-release capsule

By mouth
Brands Basic Care Lansoprazole Careone Acid Reducer Dg Health Lansoprazole Equaline Lansoprazole Equate Lansoprazole Equate Lansoprazole Delayed Release Good Neighbor Pharmacy Lansoprazole Good Sense Lansoprazole Kirkland Signature Lansoprazole Members Mark Lansoprazole Prevacid Prevacid 24 HR Topcare Lansoprazole Up And Up Lansoprazole
How this form is used
What it may be used for
  • Equate Lansoprazole and Basic Care Lansoprazole capsules are labeled to treat frequent heartburn (2 or more days a week) in adults.
Important instructions
  • Equate Lansoprazole and Basic Care Lansoprazole capsules: swallow 1 capsule whole with water before eating in the morning.
  • Do not crush or chew the capsules, and do not take more than 1 a day.
  • For these over-the-counter capsules, take for 14 days and do not use longer unless a doctor directs it.
Available strengths 2 strengths
15 mg 30 mg
194 FDA-listed product records ⓘ

Delayed-release orally disintegrating tablet

By mouth
Brands Basic Care Lansoprazole Equate Lansoprazole Good Sense Lansoprazole Prevacid SoluTab topcare Lansoprazole
How this form is used
What it may be used for
  • Prevacid SoluTab is a prescription tablet used for duodenal and gastric ulcers, GERD, erosive esophagitis and Zollinger-Ellison syndrome.
  • Equate Lansoprazole, Basic Care Lansoprazole and Good Sense Lansoprazole tablets are labeled for adult use with directions for a 14-day course.
Important instructions
  • Prevacid SoluTab: do not break, cut or chew. Place on the tongue and let it dissolve, with or without water.
  • Equate Lansoprazole, Basic Care Lansoprazole and Good Sense Lansoprazole tablets: take 1 tablet before eating in the morning.
  • These tablets can also be swallowed whole with water.
  • Do not take these over-the-counter tablets with alcohol or for more than 14 days unless a doctor directs it.
Available strengths 2 strengths
15 mg 30 mg
49 FDA-listed product records ⓘ

Orally disintegrating tablet

By mouth
How this form is used
What it may be used for
  • Lansoprazole delayed-release orally disintegrating tablets are used for duodenal and gastric ulcers, GERD, erosive esophagitis and Zollinger-Ellison syndrome.
Important instructions
  • Lansoprazole orally disintegrating tablets: do not break, cut or chew.
  • Place the tablet on the tongue and let it dissolve, with or without water, until the particles can be swallowed.
Available strengths 2 strengths
15 mg 30 mg
8 FDA-listed product records ⓘ

Lansoprazole on the U.S. market: products, makers and brands

How Lansoprazole appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

60 companies list 124 Lansoprazole product records with the FDA, mostly as delayed-release capsule, delayed-release orally disintegrating tablet, orally disintegrating tablet; the earliest marketing or approval year on record is 1995. Brand names on the directory include Prevacid, Prevacid 24HR, Prevacid SoluTab and 13 more; the rest are generics.

3
Dose forms ⓘ
60
Labelers (makers, repackagers, distributors)
19
Brand names
124
FDA-listed product records ⓘ
1995
Earliest FDA record ⓘ

FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

Also listed with the FDA, not a patient dose form: Powder (21) · Kit (3) · Pellet (2) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Bryant Ranch Prepack9%
NuCare Pharmaceuticals,Inc.8%
A-S Medication Solutions4%
Amazon.com Services LLC4%
Mylan Pharmaceuticals Inc.3%
Preferred Pharmaceuticals Inc.3%
Other makers69%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

How widely Lansoprazole is used (Medicaid data)

A general measure of how commonly Lansoprazole is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Lansoprazole is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

322,236
Medicaid prescriptions filled (Q1–Q4 2025)
$14.5M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Lansoprazole prescribed? Of the 1,601 medications we measure, Lansoprazole ranks #316 by Medicaid prescriptions — more than 80% of them.

Where Lansoprazole ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #316 of 1,601
#311 Fluvoxamine 332,998 Rx #312 Ubrogepant 329,850 Rx #313 Midodrine 328,426 Rx #314 Dexamethasone / Neomyc... 327,807 Rx #315 Prochlorperazine 323,439 Rx #316 Lansoprazole 322,236 Rx #317 Fluocinolone 320,047 Rx #318 Bevacizumab Injection 309,873 Rx #319 Temazepam 303,646 Rx #320 Nitroglycerin Sublingu... 303,475 Rx #321 Methoxy Polyethylene G... 301,411 Rx

Utilization by Lansoprazole product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 30 mg delayed release oral capsule is the most-dispensed Lansoprazole product — about 70% of these Medicaid prescriptions.

lansoprazole 30 MG Delayed Release Oral Capsule Most dispensed

224,819 Medicaid prescriptions (Q1–Q4 2025) 70% of Lansoprazole prescriptions shown $3.5M gross reimbursement (before rebates) ≈ $16 per prescription (gross)

Summed across the 21 of 170 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 311277

lansoprazole 15 MG Delayed Release Oral Capsule

39,101 Medicaid prescriptions (Q1–Q4 2025) 12% of Lansoprazole prescriptions shown $697,130 gross reimbursement (before rebates) ≈ $18 per prescription (gross)

Summed across the 12 of 246 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 596843

lansoprazole 30 MG Disintegrating Oral Tablet

29,460 Medicaid prescriptions (Q1–Q4 2025) 9% of Lansoprazole prescriptions shown $5.6M gross reimbursement (before rebates) ≈ $191 per prescription (gross)

Summed across the 8 of 20 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 351260

lansoprazole 15 MG Disintegrating Oral Tablet

28,169 Medicaid prescriptions (Q1–Q4 2025) 9% of Lansoprazole prescriptions shown $4.5M gross reimbursement (before rebates) ≈ $161 per prescription (gross)

Summed across the 8 of 29 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 351261

Other Lansoprazole products — combination packs and listings not yet matched to a specific clinical product (kept visible so every prescription is accounted for)

687 Medicaid prescriptions (Q1–Q4 2025) <1% of Lansoprazole prescriptions shown $153,218 gross reimbursement (before rebates) ≈ $223 per prescription (gross)

Summed across the 3 of 164 listed NDC products with Medicaid activity.

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Lansoprazole, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 52 of 629 listed Lansoprazole NDCs with Medicaid activity.

Compare Lansoprazole products

A representative set of FDA-listed product records for Lansoprazole — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 104 of 124 products — FDA National Drug Code Directory. See every product, package size and price: browse all 124 Lansoprazole NDCs →

Lansoprazole recall history

A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.

The FDA’s enforcement reports list 3 Lansoprazole recalls since July 2021, covering 5 product listings. None of them is still listed as ongoing. A recall names specific lots from one company, so check the lot number on your own bottle rather than assuming every product is affected; your pharmacist can check whether your supply came from an affected lot.

Class II Jul 13, 2022 · Terminated · Dr. Reddy's Laboratories, Inc.
FAILED DISSOLUTION SPECIFICATIONS
  • Lansoprazole Delayed-Release Orally Disintegrating Tablets, 35 mg, 100-count blisters per carton, 10 Packs of 10 Tablets Each, Rx Only, Distributed by: Dr. Reddy's Laboratories, Inc., Princeton, NJ 0… Lots: Lot T2100515, Exp 01/2023 FDA record D-1288-2022 →
  • Lansoprazole Delayed-Release Orally Disintegrating Tablets, 15 mg, 100-count blisters per carton, 10 Packs of 10 Tablets Each, Rx Only, Distributed by: Dr. Reddy's Laboratories, Inc., Princeton, NJ 0… Lots: Lot T2100514, Exp 01/2023 FDA record D-1287-2022 →
Class II Apr 15, 2022 · Terminated · Dr. Reddy's Laboratories, Inc.
Failed Dissolution Specifications
  • Lansoprazole Delayed-Release Orally Disintegrating Tablets, 30 mg, 10 Packs of 10 Tablets each, 100 Tablets per blister pack, Rx Only, Distributed by: Dr. Reddy's Laboratories, Inc., Princeton, NJ 08… Lots: Lot #: T2000645, Exp 07/2022 FDA record D-0853-2022 →
Class II Mar 23, 2022 · Terminated · Dr. Reddy's Laboratories, Inc.
Failed Dissolution Specifications; during long term stability testing.
  • Lansoprazole Delayed-Release Capsules, USP, 30 mg, 90-count bottle, Rx Only, Manufactured By: Dr. Reddy's Laboratories Limited, Bachupally - 500 090, India, NDC 55111-399-90. Lots: Lot# C2102911, Exp. 12/2023 FDA record D-0738-2022 →
  • Lansoprazole Delayed-Release Capsules, USP, 15 mg, a) 30-count bottle, (NDC 55111-398-30), b) 90-count bottle, (55111-398-90), Rx Only, Manufactured. By: Dr. Reddy's Laboratories Limited, Bachupally… Lots: Lot # a) C2103093, Exp. 12/2023; b)C2103092, Exp. 12/2023. FDA record D-0737-2022 →

Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Lansoprazole RxCUI 17128 3 dose forms · 5 strengths
  1. Dose form (SCDF) Delayed Release Oral Capsule RxCUI 378648 In current FDA listings
    Clinical drug / strength (SCD) 15 MG RxCUI 596843 30 MG RxCUI 311277
  2. Dose form (SCDF) Disintegrating Oral Tablet RxCUI 706238 No current FDA listing
    Clinical drug / strength (SCD) 15 MG RxCUI 351261 30 MG RxCUI 351260
  3. Dose form (SCDF) Injectable Solution RxCUI 477263 No current FDA listing
    Clinical drug / strength (SCD) 6 MG/ML RxCUI 477260

Look up RxCUI 17128 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

Lansoprazole brand names

Lansoprazole is sold under 16 brand names in the FDA directory — Prevacid, Prevacid 24HR, Prevacid SoluTab, basic care lansoprazole and others. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.

Prevacid Prevacid 24HR Prevacid SoluTab basic care lansoprazole Good Sense Lansoprazole topcare Lansoprazole careone acid reducer equate lansoprazole Kirkland Signature Lansoprazole equaline lansoprazole dg health lansoprazole good neighbor pharmacy lansoprazole up and up lansoprazole Prevacid 24 HR equate lansoprazole delayed release Members Mark Lansoprazole

Who makes Lansoprazole: manufacturers and labelers

60 companies list Lansoprazole products with the FDA. By number of product records, the largest are Bryant Ranch Prepack, NuCare Pharmaceuticals,Inc., A-S Medication Solutions. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.

Bryant Ranch Prepack 11 NuCare Pharmaceuticals,Inc. 10 A-S Medication Solutions 5 Amazon.com Services LLC 5 Mylan Pharmaceuticals Inc. 4 Preferred Pharmaceuticals Inc. 4 Teva Pharmaceuticals USA, Inc. 4 Dr. Reddy's Laboratories Inc. 3 L. Perrigo Company 3 NorthStar Rx LLC 3 Takeda Pharmaceuticals America, Inc. 3 Advanced Rx Pharmacy of Tennessee, LLC 2 Ajanta Pharma USA Inc. 2 American Health Packaging 2 Ascend Laboratories, LLC 2 Aurobindo Pharma Limited 2 BluePoint Laboratories 2 CVS Pharmacy 2 Camber Pharmaceuticals, Inc. 2 Cardinal Health 107, LLC 2 Dr.Reddy's Laboratories Ltd. 2 Lifestar Pharma LLC. 2 Macleods Pharmaceuticals Limited 2 Proficient Rx LP 2

…and 36 more on the FDA NDC directory.

Lansoprazole drug class (RxNorm)

Lansoprazole belongs to the Proton Pump Inhibitor class.

Pharmacologic class Proton Pump Inhibitor
Drug family (ATC) Proton pump inhibitors
How it works Proton Pump Inhibitors

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

Sources for this Lansoprazole page

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Jul 8, 2025
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Lansoprazole.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Lansoprazole after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
116
Finished products in the current FDA directory
124
Companies listing them (makers, repackagers, distributors)
60
FDA labeler codes behind them ⓘ
60
Linked representative label ⓘ
Takeda Pharmaceuticals America, Inc.
Linked label effective
Jul 8, 2025
Composite sections available
25
Linked SPL Set ID
71ba78cb-7e46-43eb-9425-fa130f537f84
Linked SPL Document ID
45f1d5ff-d884-4e40-a16c-313a4e21e32c
Open the linked representative label on DailyMed ↗

How this page is built

HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Takeda Pharmaceuticals America, Inc. is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →