Drug & supplement interaction

Humann Superbeets Heart Chews + Acetaminophen, Caffeine, Codeine, Salicylamide

Acetaminophen, Caffeine, Codeine, Salicylamide brand names: Codalan No.1, Codalan No.2, Codalan No.3.

Minor Interaction
Medically reviewed by · Updated November 2023
The bottom line Minor

Acetaminophen, Caffeine, Codeine, Salicylamide falls into 4 drug categories that Humann Superbeets Heart Chews can interact with; the most serious is rated minor. Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Read the full interaction report
SeverityMinor
LikelihoodUnlikely
Interactions4
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Humann Superbeets Heart Chews and Acetaminophen, Caffeine, Codeine, Salicylamide

These two interact in 4 distinct ways. Each one is explained separately below.

Why Are There 4 Interactions?

Humann Superbeets Heart Chews interacts with whole categories of medication. Acetaminophen, Caffeine, Codeine, Salicylamide falls into 4 of those categories, so it can interact with Humann Superbeets Heart Chews in 4 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Minor).

Minor

Cytochrome P450 2D6 (Cyp2D6) Substrates

1 of 4

Why this applies to Acetaminophen, Caffeine, Codeine, Salicylamide

Acetaminophen, Caffeine, Codeine, Salicylamide falls under Cytochrome P450 2D6 (Cyp2D6) Substrates — the group Humann Superbeets Heart Chews interacts with.

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews). Laboratory studies suggest that grape seed extract might have inhibitory effects on the CYP2D6 metabolizing enzyme. If this enzyme is inhibited, drugs metabolized by it may undergo slower metabolism, potentially leading to (in many cases) higher-than-normal drug levels. Elevated drug levels can increase the risk of experiencing side effects. However, it's crucial to highlight that, as of now, there is no documented or reported instance of this specific interaction occurring in human studies.
Severity Minor Likelihood Unlikely Evidence D

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's a wrinkle worth knowing about with this combo. The codeine in your Codalan tablets is actually a prodrug, meaning it doesn't do much until your body converts it into morphine using an enzyme called CYP2D6. That conversion is what gives you pain relief. The grape seed extract in SuperBeets chews has been shown in lab studies only to possibly slow down that same enzyme.

So if anything happened here, you might get a little less pain relief from the codeine, not more, since less of it would turn into morphine. But honestly, this is a minor and unlikely interaction, and it has never been documented in real people. I wouldn't lose sleep over it. Still, mention it to your pharmacist if your pain control feels off.

Contact Dr. Brian directly if you have additional questions on this interaction
Minor

Cytochrome P450 3A4 (Cyp3A4) Substrates

2 of 4

Acetaminophen, Caffeine, Codeine, Salicylamide also falls under Cytochrome P450 3A4 (Cyp3A4) Substrates.

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews). Laboratory studies suggest that grape seed extract might have inhibitory effects on the CYP3A4 metabolizing enzyme. If this enzyme is inhibited, drugs metabolized by it may undergo slower metabolism, potentially leading to (in many cases) higher-than-normal drug levels. Elevated drug levels can increase the risk of experiencing side effects. However, it's important to point out that there is no documented or reported instance of this specific interaction occurring in human studies.
Severity Minor Likelihood Unlikely Evidence D

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist for your Codalan combo (acetaminophen, caffeine, codeine, and salicylamide). The grape seed extract in SuperBeets Heart Chews may, in lab dishes, gently slow down the CYP3A4 enzyme. One of CYP3A4's jobs is to help clear caffeine and to help break codeine down a different way. If it slows a touch, those ingredients could linger slightly longer, which in theory might mean a bit more jitteriness, sleep trouble, or, with codeine, more drowsiness or constipation.

The honest truth, though, is this is very unlikely to cause real problems. It's based on test-tube data, with no actual cases reported in people, and the chews only contain a small amount. Still, if codeine already makes you sleepy, mention this combo to your pharmacist or doctor.

Contact Dr. Brian directly if you have additional questions on this interaction
Minor

Cytochrome P450 2E1 (Cyp2E1) Substrates

3 of 4

Acetaminophen, Caffeine, Codeine, Salicylamide also falls under Cytochrome P450 2E1 (Cyp2E1) Substrates.

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews). Laboratory studies suggest that grape seed extract might have inhibitory effects on the CYP2E1 metabolizing enzyme. If this enzyme is inhibited, drugs metabolized by it may undergo slower metabolism, potentially leading to (in many cases) higher-than-normal drug levels. Elevated drug levels can increase the risk of experiencing side effects. However, it's important to point out that there is no documented or reported instance of this specific interaction occurring in human studies.
Severity Minor Likelihood Unlikely Evidence D

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the honest picture with these chews and your Codalan combo. The grape seed extract in SuperBeets might slightly slow an enzyme called CYP2E1, which plays a part in how your body handles the acetaminophen portion of this medicine. In theory, a slower breakdown could nudge acetaminophen levels up a bit. But this comes only from lab studies, and there's no real-world report of it actually happening in people.

So I wouldn't lose sleep over it. If anything, the bigger thing to watch with acetaminophen is your total daily dose to protect your liver, and not doubling up on other products that also contain it. The codeine, caffeine, and salicylamide pieces aren't really the concern here. Still, run it by your pharmacist to be safe, especially if you take blood pressure medicine.

Contact Dr. Brian directly if you have additional questions on this interaction
Minor

Cytochrome P450 2E1 (Cyp2E1) Substrates

4 of 4

Acetaminophen, Caffeine, Codeine, Salicylamide also falls under Cytochrome P450 2E1 (Cyp2E1) Substrates.

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews). Laboratory studies suggest that grape seed extract might have inhibitory effects on the CYP2E1 metabolizing enzyme. If this enzyme is inhibited, drugs metabolized by it may undergo slower metabolism, potentially leading to (in many cases) higher-than-normal drug levels. Elevated drug levels can increase the risk of experiencing side effects. However, it's important to point out that there is no documented or reported instance of this specific interaction occurring in human studies.
Severity Minor Likelihood Unlikely Evidence D

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist. The grape seed extract in these chews might slow down an enzyme called CYP2E1, and one piece of this combo medicine, the acetaminophen (Tylenol), is partly handled by that enzyme. In theory, if that pathway slows a little, acetaminophen could clear slightly slower. The reassuring part is that this is based only on lab studies, with no real-world cases reported, and it's rated minor and unlikely.

Practically speaking, two chews aren't likely to cause trouble. The bigger thing I'd watch with this product is that beetroot can gently lower blood pressure, and the codeine piece can already make you drowsy or constipated. If you take it daily, just run it by your pharmacist to be safe.

Contact Dr. Brian directly if you have additional questions on this interaction

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Humann Superbeets Heart Chews Also Interacts With Other Medications

Humann Superbeets Heart Chews has 893 minor known drug interactions in our database — the Acetaminophen, Caffeine, Codeine, Salicylamide one above is among them. If you take anything else, check it against the full list below.

Minor 893 No known interaction 1,937 (incl. Acetaminophen, Caffeine, Codeine, Salicylamide)
Taking anything else?

Check Another of Your Medications Against Humann Superbeets Heart Chews

Covers the 2,830 medications we’ve checked against Humann Superbeets Heart Chews. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Acetaminophen, Caffeine, Codeine, Salicylamide

This page covers Humann Superbeets Heart Chews only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Acetaminophen, Caffeine, Codeine, Salicylamide page lists 303 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Ephedra (major).

By severity: 15 major · 244 moderate · 44 minor.

Open the Acetaminophen, Caffeine, Codeine, Salicylamide interaction page

How much people look this up

Where Humann Superbeets Heart Chews and Acetaminophen, Caffeine, Codeine, Salicylamide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Humann Superbeets Heart Chews
Steady interest

#996 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Acetaminophen, Caffeine, Codeine, Salicylamide
Top 10%

#166 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Humann Superbeets Heart Chews

What is Humann Superbeets Heart Chews?

Humann Superbeets Heart Chews
  • Heart and cardiovascular support
  • Healthy blood pressure support
  • Nitric oxide and blood flow support
  • Antioxidant support
  • Energy and circulation

SuperBeets Heart Chews are a beetroot- and grape-seed-based supplement marketed to support healthy blood flow, blood pressure, and nitric oxide production. Some research on dietary nitrate from beets and on grape seed extract suggests modest cardiovascular benefits, but evidence for this specific product is limited. It is generally well tolerated, but talk with your pharmacist or doctor before using it, especially if you have heart problems or take blood pressure medicine.

Read the full Humann Superbeets Heart Chews monograph & all interactions
Keep checking

Other Drugs & Humann Superbeets Heart Chews

Browse every other medication we’ve checked against Humann Superbeets Heart Chews — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
893Minor
1,936No known interaction
893 Minor 1,936 No interaction
Minor

893 interactions

Showing 60 of 893 minor interactions — see all 893 on the Humann Superbeets Heart Chews page.

No interaction 1,936 drugs checked — show the list

We also checked Humann Superbeets Heart Chews against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,936 medications checked with no known interaction — see the full Humann Superbeets Heart Chews list.

See the full Humann Superbeets Heart Chews interactions page
See every supplement checked against Acetaminophen, Caffeine, Codeine, Salicylamide, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Humann Superbeets Heart Chews monograph › Uses, safety, and every drug interaction in one place Acetaminophen, Caffeine, Codeine, Salicylamide supplement interactions › Every supplement checked against Acetaminophen, Caffeine, Codeine, Salicylamide, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Humann Superbeets Heart Chews and Acetaminophen, Caffeine, Codeine, Salicylamide Together: Common Questions

Can you take Humann Superbeets Heart Chews with Acetaminophen, Caffeine, Codeine, Salicylamide?
There is only a minor interaction, which is usually not serious. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 4 interactions listed for Humann Superbeets Heart Chews and Acetaminophen, Caffeine, Codeine, Salicylamide?
Acetaminophen, Caffeine, Codeine, Salicylamide belongs to more than one drug category, and Humann Superbeets Heart Chews interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Humann Superbeets Heart Chews and Acetaminophen, Caffeine, Codeine, Salicylamide interaction?
We rate it Minor. This interaction is generally not clinically significant, but it remains worth noting and discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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