Medication interaction hub

What Supplements Interact with Acetaminophen, Caffeine, Codeine, Salicylamide?

Acetaminophen, Caffeine, Codeine, Salicylamide brand names: Codalan No.1, Codalan No.2, Codalan No.3. Every interaction below applies to the brands too.

303 Interactions 15 Major 244 Moderate 44 Minor
Curated & coded by · Clinical Pharmacist · Updated September 24, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Acetaminophen, Caffeine, Codeine, Salicylamide? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Acetaminophen, Caffeine, Codeine, Salicylamide against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

303 supplements and herbal ingredients have interactions with Acetaminophen, Caffeine, Codeine, Salicylamide on file in the HelloPharmacist interaction database — 15 rated major, 244 moderate, and 44 minor. The most serious involve Beer, Grapefruit, Siberian Cocklebur, Wine and 1,4-butanediol.

Our assessment: with 15 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Acetaminophen, Caffeine, Codeine, Salicylamide.

Major 15 Moderate 244 Minor 44 No known interaction 1,149

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Acetaminophen, Caffeine, Codeine, Salicylamide: Top Interactions at a Glance

The Acetaminophen, Caffeine, Codeine, Salicylamide supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 303 interacting ingredients — plus 1,149 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Acetaminophen, Caffeine, Codeine, Salicylamide Combinations Today

The Acetaminophen, Caffeine, Codeine, Salicylamide + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Probable Vitamin C + Acetaminophen, Caffeine, Codeine, Salicylamidei

High-dose vitamin C might slightly prolong the clearance of acetaminophen.

Read the full interaction Moderate Likelihood Probable Caffeine + Acetaminophen, Caffeine, Codeine, Salicylamidei

Theoretically, concomitant use might increase stimulant adverse effects.

Read the full interaction Moderate Likelihood Possible Ashwagandha + Acetaminophen, Caffeine, Codeine, Salicylamidei

Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.

Read the full interaction Moderate Likelihood Possible Black Pepper + Acetaminophen, Caffeine, Codeine, Salicylamidei

Theoretically, black pepper might increase levels of drugs metabolized by CYP2D6.

Read the full interaction Moderate Likelihood Possible Beet + Acetaminophen, Caffeine, Codeine, Salicylamidei

Theoretically, beet might increase the levels of CYP3A4 substrates.

Read the full interaction Minor Likelihood Possible Vitamin D + Acetaminophen, Caffeine, Codeine, Salicylamidei

Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.

Read the full interaction
The complete list

Every Supplement Checked Against Acetaminophen, Caffeine, Codeine, Salicylamide

All 1,452 ingredients in our database, ranked by severity — 303 with a Acetaminophen, Caffeine, Codeine, Salicylamide interaction on file and 1,149 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Acetaminophen, Caffeine, Codeine, Salicylamide?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Vitamin C with Acetaminophen, Caffeine, Codeine, Salicylamide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. High-dose vitamin C might slightly prolong the clearance of acetaminophen.

Full Vitamin C + Acetaminophen, Caffeine, Codeine, Salicylamide answer

Can you take Caffeine with Acetaminophen, Caffeine, Codeine, Salicylamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Caffeine + Acetaminophen, Caffeine, Codeine, Salicylamide answer

Can you take Ashwagandha with Acetaminophen, Caffeine, Codeine, Salicylamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.

Full Ashwagandha + Acetaminophen, Caffeine, Codeine, Salicylamide answer

Can you take Black Pepper with Acetaminophen, Caffeine, Codeine, Salicylamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black pepper might increase levels of drugs metabolized by CYP2D6.

Full Black Pepper + Acetaminophen, Caffeine, Codeine, Salicylamide answer

Can you take Beet with Acetaminophen, Caffeine, Codeine, Salicylamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, beet might increase the levels of CYP3A4 substrates.

Full Beet + Acetaminophen, Caffeine, Codeine, Salicylamide answer

Can you take Dendrobium with Acetaminophen, Caffeine, Codeine, Salicylamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. The dendrobium constituent dendrobine is reported to have convulsant effects.

Full Dendrobium + Acetaminophen, Caffeine, Codeine, Salicylamide answer

Can you take Devil's Claw with Acetaminophen, Caffeine, Codeine, Salicylamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Full Devil's Claw + Acetaminophen, Caffeine, Codeine, Salicylamide answer

Can you take Dhea with Acetaminophen, Caffeine, Codeine, Salicylamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Full Dhea + Acetaminophen, Caffeine, Codeine, Salicylamide answer

Can you take Dimethylhexylamine (dmha) with Acetaminophen, Caffeine, Codeine, Salicylamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining DMHA with stimulant drugs might increase the risk of adverse cardiovascular effects.

Full Dimethylhexylamine (dmha) + Acetaminophen, Caffeine, Codeine, Salicylamide answer

Can you take Diosmin with Acetaminophen, Caffeine, Codeine, Salicylamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, diosmin might inhibit the metabolism of CYP3A4 substrates.

Full Diosmin + Acetaminophen, Caffeine, Codeine, Salicylamide answer

Can you take Dyer's Broom with Acetaminophen, Caffeine, Codeine, Salicylamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, dyer's broom might reduce the clearance of caffeine.

Full Dyer's Broom + Acetaminophen, Caffeine, Codeine, Salicylamide answer

Can you take Elecampane with Acetaminophen, Caffeine, Codeine, Salicylamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, elecampane may cause additive sedative effects when taken with CNS depressants.

Full Elecampane + Acetaminophen, Caffeine, Codeine, Salicylamide answer

Can you take Eleuthero with Acetaminophen, Caffeine, Codeine, Salicylamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.

Full Eleuthero + Acetaminophen, Caffeine, Codeine, Salicylamide answer

Can you take English Ivy with Acetaminophen, Caffeine, Codeine, Salicylamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.

Full English Ivy + Acetaminophen, Caffeine, Codeine, Salicylamide answer

Can you take Epistane with Acetaminophen, Caffeine, Codeine, Salicylamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive adverse hepatotoxic effects.

Full Epistane + Acetaminophen, Caffeine, Codeine, Salicylamide answer

Can you take Ergot with Acetaminophen, Caffeine, Codeine, Salicylamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Co-administration of stimulant drugs with ergot may increase the risk of vasoconstriction.

Full Ergot + Acetaminophen, Caffeine, Codeine, Salicylamide answer

Can you take Eucalyptus with Acetaminophen, Caffeine, Codeine, Salicylamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eucalyptus might increase the levels of CYP1A2 substrates.

Full Eucalyptus + Acetaminophen, Caffeine, Codeine, Salicylamide answer

Can you take European Barberry with Acetaminophen, Caffeine, Codeine, Salicylamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.

Full European Barberry + Acetaminophen, Caffeine, Codeine, Salicylamide answer

Can you take False Unicorn with Acetaminophen, Caffeine, Codeine, Salicylamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro, false unicorn extract inhibits cytochrome P450 2D6 (CYP2D6) activity.

Full False Unicorn + Acetaminophen, Caffeine, Codeine, Salicylamide answer

Can you take Fennel with Acetaminophen, Caffeine, Codeine, Salicylamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.

Full Fennel + Acetaminophen, Caffeine, Codeine, Salicylamide answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Acetaminophen, Caffeine, Codeine, Salicylamide is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Acetaminophen, Caffeine, Codeine, Salicylamide, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Acetaminophen, Caffeine, Codeine, Salicylamide sits in 17 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Codeine, Salicylamide through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Codeine, Salicylamide through this category.

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Codeine, Salicylamide through this category.

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Codeine, Salicylamide through this category.

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Codeine, Salicylamide through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Codeine, Salicylamide through this category.

Cytochrome P450 2E1 (Cyp2E1) Substrates 24 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

24 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Codeine, Salicylamide through this category.

Caffeine 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Codeine, Salicylamide through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Codeine, Salicylamide through this category.

Glucuronidated Drugs 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Codeine, Salicylamide through this category.

Acetaminophen (Tylenol, Others) 8 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

8 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Codeine, Salicylamide through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Codeine, Salicylamide through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Codeine, Salicylamide through this category.

Methylxanthines 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Codeine, Salicylamide through this category.

Narcotic Drugs 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Codeine, Salicylamide through this category.

Codeine 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Acetaminophen, Caffeine, Codeine, Salicylamide through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Acetaminophen, Caffeine, Codeine, Salicylamide through this category.

Related: does Acetaminophen, Caffeine, Codeine, Salicylamide deplete any nutrients?

Acetaminophen, Caffeine, Codeine, Salicylamide has 6 reported nutrient associations in the research literature — see the Acetaminophen, Caffeine, Codeine, Salicylamide nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Acetaminophen, Caffeine, Codeine, Salicylamide

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Acetaminophen, Caffeine, Codeine, Salicylamide.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

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Prefer typing? The interaction checker looks up products by name too.

Pharmacist Counseling Corner

Acetaminophen, Caffeine, Codeine, Salicylamide & Supplements: Common Questions

What supplements interact with Acetaminophen, Caffeine, Codeine, Salicylamide?
Our database currently documents 303 ingredients with a known Acetaminophen, Caffeine, Codeine, Salicylamide interaction (15 major, 244 moderate, 44 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 303. The highest-ranked right now: Beer, Grapefruit, Siberian Cocklebur.
Which Acetaminophen, Caffeine, Codeine, Salicylamide supplement interactions are the most serious?
Focus on the major group: Beer, Grapefruit, Siberian Cocklebur, Wine and 1,4-butanediol, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Acetaminophen, Caffeine, Codeine, Salicylamide?
Plenty of supplements coexist fine with Acetaminophen, Caffeine, Codeine, Salicylamide; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Codalan No.1 have the same supplement interactions as Acetaminophen, Caffeine, Codeine, Salicylamide?
Yes — Codalan No.1, Codalan No.2, Codalan No.3 all contain Acetaminophen, Caffeine, Codeine, Salicylamide, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Acetaminophen, Caffeine, Codeine, Salicylamide deplete any vitamins or nutrients?
It might — Acetaminophen, Caffeine, Codeine, Salicylamide has 6 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Acetaminophen, Caffeine, Codeine, Salicylamide nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Acetaminophen, Caffeine, Codeine, Salicylamide and my other medications?
This page covers Acetaminophen, Caffeine, Codeine, Salicylamide against supplements and herbal ingredients. Checking Acetaminophen, Caffeine, Codeine, Salicylamide against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 24, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.