Macitentan

Generic name: Pronounced as (ma'' si ten' tan)
Brand names
  • Opsumit®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 01/15/2019

For female patients:

Do not take macitentan if you are pregnant or plan to become pregnant. There is a high risk that macitentan will cause harm to the fetus.

Because of the risk of fetal harm, a program called OPSUMIT Risk Evaluation and Mitigation Strategy (OPSUMIT REMS) has been set up to make sure that pregnant woman do not take macitentan, and that woman do not become pregnant while taking macitentan. All females, including females who are not able to get pregnant, can only receive macitentan if they are registered with OPSUMIT REMS, have a prescription from a doctor who is registered with OPSUMIT REMS, and fill the prescription at a pharmacy that is registered with OPSUMIT REMS.

Your doctor will register you in OPSUMIT REMS. Your doctor will tell you about the risks of macitentan, especially the risks of serious birth defects if taken while pregnant. You must sign an informed consent sheet stating that you understand this information in order for your doctor to register you.

Your doctor will also determine if you are able to become pregnant. If you have reached puberty (when child's body becomes physically mature and capable of having a child), have a uterus, and have not yet gone through menopause ('change in life' end of monthly menstrual periods) you are considered to be a female who is able to become pregnant, and you will have to follow certain additional rules in order to receive macitentan.

For females who are able to become pregnant:

You must use reliable birth control throughout your treatment with macitentan, and for 1 month after your final dose. Your doctor will tell you which forms of birth control are acceptable, and will give your written information about birth control. In most cases you will be required to use two forms of birth control in order to prevent pregnancy while taking macitentan.

You will have to take a pregnancy test before starting treatment, every month during treatment, and 1 month after your final dose in order to be able to receive macitentan. Your doctor will order the pregnancy tests for you. The pharmacy will not dispense macitentan to you until they have confirmed that you have taken your required pregnancy tests.

You must not have unprotected sex while taking macitentan.

Call your doctor right away if you have had unprotected sex, think your birth control failed, missed your period, or think you may be pregnant for any reason. He will discuss your medical options with you. Do not wait until your next appointment to discuss this with your doctor.

Tell your doctor if you do not understand everything you were told about birth control, or if you do not think you will be able to use acceptable forms of birth control at all times during your treatment.

If you are a parent or guardian of a female who had not yet reached puberty, check your child regularly to see if she is developing any signs of puberty (breast buds, pubic hair )and let her doctor know about any changes.

For all patients:

Macitentan is not available at retail pharmacies. Your medication will be mailed to you from a specialty pharmacy that is registered with OPSUMIT REMS. If you are a female who has not reached puberty or a female who is able to become pregnant you will only receive a 30 day supply at a time. Ask your doctor if you have any questions about how you will receive your medication.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with macitentan and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide.

Macitentan is used to manage the symptoms of pulmonary arterial hypertension (PAH; high blood pressure in the vessels that carry blood to the lungs). Macitentan is in a class of medications called endothelin receptor antagonists. It works by stopping the action of endothelin, a natural substance that causes blood vessels to narrow and prevents normal blood flow in people who have PAH.

Macitentan comes as a tablet to take by mouth. It is usually taken with or without food once a day. Take macitentan at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take macitentan exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the tablets whole; do not split, chew, or crush them.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking macitentan,

  • tell your doctor and pharmacist if you are allergic to macitentan, any other medications, or any of the ingredients in macitentan tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.

  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: carbamazepine (Carbatrol, Epitol, Equetro, Tegretol), clarithromycin (Biaxin, in Prevpac); efavirenz (Sustiva); certain HIV protease inhibitors such as nelfinavir (Viracept), indinavir (Crixivan), and ritonavir (Norvir, in Kaletra); itraconazole (Onmel, Sporanox); ketoconazole; nefazodone; nevirapine Viramune); phenobarbital; phenytoin (Dilantin, Phenytek); rifabutin (Mycobutin); and rifampin (Rifadin, Rifamate, Rifater, Rimactane). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with macitentan, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

  • tell your doctor what herbal products you are taking, especially St. John's wort.

  • tell your doctor if you have or have ever had anemia (condition in which red blood cells do not bring enough oxygen to the organs) or liver disease.

  • do not breastfeed while taking this medication.

  • you should know that this medication may decrease fertility in men. Talk to your doctor about the risks of taking macitentan.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Macitentan may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • stuffy nose

    • sore throat

    • cough

    • flu like symptoms

    • headache

    • urgent, frequent, or painful urination

    • rash

  • Some side effects can be serious. If you experience any of these symptoms, stop taking macitentan and call your doctor immediately or get emergency medical treatment:

    • itchy skin

    • dark urine

    • yellowing of your skin or eyes

    • pain in the upper right part of your stomach

    • unexplained nausea or vomiting

    • loss of appetite

    • extreme tiredness

    • fever

    • swelling of the face, throat, tongue, lips, and eyes

    • difficulty swallowing or breathing

    • hoarseness

    • shortness of breath, especially when lying down

    • coughing up pink, frothy sputum or blood

    • unusual weight increase

    • swelling of the ankles or legs

  • Macitentan may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

  • headache

  • nausea

  • vomiting

Keep all appointments with your doctor and the laboratory. Your doctor may order tests to see how well your liver is working, and to check for anemia before starting treatment and from time to time during your treatment with macitentan.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Candesartan Candesartan Macitentan may increase the hypotensive activities of Candesartan.
Cilostazol Cilostazol Cilostazol may decrease the excretion rate of Macitentan which could result in a higher serum level.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Conjugated estrogens may decrease the excretion rate of Macitentan which could result in a higher serum level.
Fenofibrate Fenofibrate Fenofibrate may decrease the excretion rate of Macitentan which could result in a higher serum level.
Guanfacine Guanfacine Guanfacine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Magnesium Hydroxide Magnesium Hydroxide Macitentan may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Methylergonovine Methylergonovine Methylergometrine may decrease the antihypertensive activities of Macitentan.
Mycophenolate Mycophenolate Mycophenolic acid may decrease the excretion rate of Macitentan which could result in a higher serum level.
Naratriptan Naratriptan Naratriptan may decrease the antihypertensive activities of Macitentan.
Olsalazine Olsalazine The therapeutic efficacy of Macitentan can be decreased when used in combination with Olsalazine.
Paregoric Paregoric Morphine may increase the hypotensive activities of Macitentan.
Penbutolol Penbutolol Acebutolol may increase the hypotensive activities of Macitentan.
Potassium Potassium Potassium cation may increase the excretion rate of Macitentan which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone Prednisone Prednisone may decrease the excretion rate of Macitentan which could result in a higher serum level.
Ranitidine Ranitidine Ranitidine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Reserpine Reserpine Reserpine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Rizatriptan Rizatriptan Rizatriptan may decrease the excretion rate of Macitentan which could result in a higher serum level.
Sumatriptan Sumatriptan Sumatriptan may decrease the excretion rate of Macitentan which could result in a higher serum level.
Tacrolimus Tacrolimus Tacrolimus may decrease the excretion rate of Macitentan which could result in a higher serum level.
Tizanidine Tizanidine Tizanidine may increase the hypotensive activities of Macitentan.
Zolmitriptan Zolmitriptan Zolmitriptan may decrease the antihypertensive activities of Macitentan.
Ampicillin Injection Ampicillin Injection Ampicillin may decrease the excretion rate of Macitentan which could result in a higher serum level.
Doxycycline Injection Doxycycline Injection Doxycycline may decrease the excretion rate of Macitentan which could result in a higher serum level.
Fluconazole Injection Fluconazole Injection Fluconazole may decrease the excretion rate of Macitentan which could result in a higher serum level.
Foscarnet Injection Foscarnet Injection Foscarnet may decrease the excretion rate of Macitentan which could result in a higher serum level.
Hydromorphone Injection Hydromorphone Injection Hydromorphone may decrease the excretion rate of Macitentan which could result in a higher serum level.
Levofloxacin Injection Levofloxacin Injection Levofloxacin may decrease the excretion rate of Macitentan which could result in a higher serum level.
Meperidine Injection Meperidine Injection Meperidine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Metoclopramide Injection Metoclopramide Injection Metoclopramide may decrease the excretion rate of Macitentan which could result in a higher serum level.
Morphine Injection Morphine Injection Morphine may increase the hypotensive activities of Macitentan.
Pamidronate Injection Pamidronate Injection Pamidronic acid may decrease the excretion rate of Macitentan which could result in a higher serum level.
Vancomycin Injection Vancomycin Injection Macitentan may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Altretamine Altretamine Amphetamine may increase the hypotensive activities of Macitentan.
Cefuroxime Cefuroxime Cefuroxime may decrease the excretion rate of Macitentan which could result in a higher serum level.
Cyclosporine Cyclosporine Cyclosporine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Torsemide Torsemide Torasemide may increase the excretion rate of Macitentan which could result in a lower serum level and potentially a reduction in efficacy.
Olanzapine Olanzapine Olanzapine may increase the hypotensive activities of Macitentan.
Eprosartan Eprosartan Eprosartan may increase the hypotensive activities of Macitentan.
Meloxicam Meloxicam The therapeutic efficacy of Macitentan can be decreased when used in combination with Meloxicam.
Pantoprazole Pantoprazole Pantoprazole may decrease the excretion rate of Macitentan which could result in a higher serum level.
Telmisartan Telmisartan Telmisartan may increase the hypotensive activities of Macitentan.
Temozolomide Temozolomide Temozolomide may decrease the excretion rate of Macitentan which could result in a higher serum level.
Zaleplon Zaleplon Zaleplon may decrease the excretion rate of Macitentan which could result in a higher serum level.
Linezolid Linezolid Linezolid may increase the hypotensive activities of Macitentan.
Trimipramine Trimipramine Trimipramine may decrease the antihypertensive activities of Macitentan.
Perindopril Perindopril Perindopril may decrease the excretion rate of Macitentan which could result in a higher serum level.
Tenofovir Tenofovir Tenofovir may decrease the excretion rate of Macitentan which could result in a higher serum level.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate The therapeutic efficacy of Macitentan can be decreased when used in combination with Choline magnesium trisalicylate.
Dutasteride Dutasteride Dutasteride may decrease the antihypertensive activities of Macitentan.
Epinephrine Injection Epinephrine Injection Epinephrine may decrease the antihypertensive activities of Macitentan.
Eplerenone Eplerenone Eplerenone may increase the excretion rate of Macitentan which could result in a lower serum level and potentially a reduction in efficacy.
Olmesartan Olmesartan Olmesartan may increase the hypotensive activities of Macitentan.
Zonisamide Zonisamide Zonisamide may increase the excretion rate of Macitentan which could result in a lower serum level and potentially a reduction in efficacy.
Aripiprazole Aripiprazole The risk or severity of hypotension can be increased when Aripiprazole is combined with Macitentan.
Atomoxetine Atomoxetine Atomoxetine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Dexmethylphenidate Dexmethylphenidate Dexmethylphenidate may decrease the antihypertensive activities of Macitentan.
Atazanavir Atazanavir Atazanavir may decrease the excretion rate of Macitentan which could result in a higher serum level.
Almotriptan Almotriptan Almotriptan may decrease the excretion rate of Macitentan which could result in a higher serum level.
Eletriptan Eletriptan Eletriptan may decrease the antihypertensive activities of Macitentan.
Vardenafil Vardenafil Vardenafil may increase the antihypertensive activities of Macitentan.
Alfuzosin Alfuzosin Alfuzosin may increase the hypotensive activities of Macitentan.
Emtricitabine Emtricitabine Emtricitabine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Memantine Memantine Memantine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Tadalafil Tadalafil Tadalafil may increase the antihypertensive activities of Macitentan.
Frovatriptan Frovatriptan Frovatriptan may decrease the antihypertensive activities of Macitentan.
Apomorphine Injection Apomorphine Injection Apomorphine may increase the hypotensive activities of Macitentan.
Protriptyline Protriptyline Protriptyline may decrease the antihypertensive activities of Macitentan.
Duloxetine Duloxetine Duloxetine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Tinidazole Tinidazole Tinidazole may decrease the excretion rate of Macitentan which could result in a higher serum level.
Bosentan Bosentan Bosentan may increase the hypotensive activities of Macitentan.
Cefditoren Cefditoren Cefdinir may decrease the excretion rate of Macitentan which could result in a higher serum level.
Cyanocobalamin Injection Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Macitentan which could result in a higher serum level.
Eszopiclone Eszopiclone Eszopiclone may decrease the excretion rate of Macitentan which could result in a higher serum level.
Ganciclovir Ganciclovir Ganciclovir may decrease the excretion rate of Macitentan which could result in a higher serum level.
Ribavirin Ribavirin Ribavirin may decrease the excretion rate of Macitentan which could result in a higher serum level.
Solifenacin Solifenacin Solifenacin may decrease the antihypertensive activities of Macitentan.
Valganciclovir Valganciclovir Valganciclovir may decrease the excretion rate of Macitentan which could result in a higher serum level.
Adefovir Adefovir Adefovir may decrease the excretion rate of Macitentan which could result in a higher serum level.
Dextroamphetamine Dextroamphetamine Amphetamine may increase the hypotensive activities of Macitentan.
Isocarboxazid Isocarboxazid Isocarboxazid may increase the hypotensive activities of Macitentan.
Ramelteon Ramelteon Ramelteon may decrease the excretion rate of Macitentan which could result in a higher serum level.
Fentanyl Fentanyl Fentanyl may decrease the antihypertensive activities of Macitentan.
Pregabalin Pregabalin Pregabalin may decrease the excretion rate of Macitentan which could result in a higher serum level.
Phenylephrine Phenylephrine Phenylephrine may decrease the antihypertensive activities of Macitentan.
Ranolazine Ranolazine Ranolazine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Rasagiline Rasagiline Rasagiline may increase the hypotensive activities of Macitentan.
Sitagliptin Sitagliptin Sitagliptin may decrease the excretion rate of Macitentan which could result in a higher serum level.
Varenicline Varenicline Varenicline may decrease the excretion rate of Macitentan which could result in a higher serum level.
Albuterol Albuterol Salbutamol may decrease the excretion rate of Macitentan which could result in a higher serum level.
Paliperidone Paliperidone Paliperidone may decrease the excretion rate of Macitentan which could result in a higher serum level.
Clofarabine Injection Clofarabine Injection Clofarabine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Lubiprostone Lubiprostone Lubiprostone may decrease the excretion rate of Macitentan which could result in a higher serum level.
Rituximab Injection Rituximab Injection Macitentan may increase the hypotensive activities of Rituximab.
Aliskiren Aliskiren Macitentan may increase the hypotensive activities of Aliskiren.
Pemetrexed Injection Pemetrexed Injection Macitentan may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Lisdexamfetamine Lisdexamfetamine Lisdexamfetamine may decrease the antihypertensive activities of Macitentan.
Nabilone Nabilone Nabilone may increase the hypotensive activities of Macitentan.
Sorafenib Sorafenib Sorafenib may decrease the excretion rate of Macitentan which could result in a higher serum level.
Levocetirizine Levocetirizine Levocetirizine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Pegaptanib Injection Pegaptanib Injection Pegaptanib may decrease the excretion rate of Macitentan which could result in a higher serum level.
Azacitidine Injection Azacitidine Injection Azacitidine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Lenalidomide Lenalidomide Lenalidomide may decrease the excretion rate of Macitentan which could result in a higher serum level.
Budesonide Budesonide Budesonide may decrease the excretion rate of Macitentan which could result in a higher serum level.
Desmopressin Desmopressin Desmopressin may decrease the excretion rate of Macitentan which could result in a higher serum level.
Doripenem Injection Doripenem Injection Doripenem may decrease the excretion rate of Macitentan which could result in a higher serum level.
Arsenic Trioxide Injection Arsenic Trioxide Injection Arsenic trioxide may decrease the excretion rate of Macitentan which could result in a higher serum level.
Desvenlafaxine Desvenlafaxine Desvenlafaxine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Cevimeline Cevimeline Cevimeline may decrease the excretion rate of Macitentan which could result in a higher serum level.
Nebivolol Nebivolol Nebivolol may increase the hypotensive activities of Macitentan.
Tretinoin Tretinoin Tretinoin may increase the hypotensive activities of Macitentan.
Certolizumab Injection Certolizumab Injection Certolizumab pegol may decrease the excretion rate of Macitentan which could result in a higher serum level.
Daptomycin Injection Daptomycin Injection Daptomycin may decrease the excretion rate of Macitentan which could result in a higher serum level.
Methylnaltrexone Injection Methylnaltrexone Injection Methylnaltrexone may decrease the excretion rate of Macitentan which could result in a higher serum level.
Midazolam Midazolam Midazolam may decrease the excretion rate of Macitentan which could result in a higher serum level.
Dexrazoxane Injection Dexrazoxane Injection Dexrazoxane may decrease the excretion rate of Macitentan which could result in a higher serum level.
Milnacipran Milnacipran Milnacipran may decrease the excretion rate of Macitentan which could result in a higher serum level.
Plerixafor Injection Plerixafor Injection Plerixafor may decrease the excretion rate of Macitentan which could result in a higher serum level.
Fesoterodine Fesoterodine Fesoterodine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Betaxolol Betaxolol Betaxolol may increase the hypotensive activities of Macitentan.
Iloperidone Iloperidone Iloperidone may decrease the antihypertensive activities of Macitentan.
Prasugrel Prasugrel Prasugrel may decrease the excretion rate of Macitentan which could result in a higher serum level.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) Tolvaptan may increase the excretion rate of Macitentan which could result in a lower serum level and potentially a reduction in efficacy.
Dronedarone Dronedarone Dronedarone may decrease the antihypertensive activities of Macitentan.
Pralatrexate Injection Pralatrexate Injection Pralatrexate may decrease the excretion rate of Macitentan which could result in a higher serum level.
Palonosetron Injection Palonosetron Injection Palonosetron may decrease the excretion rate of Macitentan which could result in a higher serum level.
Saxagliptin Saxagliptin Saxagliptin may decrease the excretion rate of Macitentan which could result in a higher serum level.
Telavancin Injection Telavancin Injection Telavancin may decrease the excretion rate of Macitentan which could result in a higher serum level.
Topotecan Topotecan Topotecan may decrease the excretion rate of Macitentan which could result in a higher serum level.
Asenapine Asenapine Asenapine may decrease the antihypertensive activities of Macitentan.
Dalfampridine Dalfampridine Dalfampridine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Ceftaroline Injection Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Macitentan which could result in a higher serum level.
Lurasidone Lurasidone Lurasidone may decrease the antihypertensive activities of Macitentan.
Acetaminophen Injection Acetaminophen Injection Acetaminophen may decrease the excretion rate of Macitentan which could result in a higher serum level.
Vilazodone Vilazodone Vilazodone may decrease the antihypertensive activities of Macitentan.
Ipilimumab Injection Ipilimumab Injection Ipilimumab may decrease the excretion rate of Macitentan which could result in a higher serum level.
Denileukin Diftitox Injection Denileukin Diftitox Injection Aldesleukin may decrease the excretion rate of Macitentan which could result in a higher serum level.
Terbutaline Injection Terbutaline Injection Terbutaline may decrease the excretion rate of Macitentan which could result in a higher serum level.
Azilsartan Azilsartan Azilsartan medoxomil may increase the hypotensive activities of Macitentan.
Roflumilast Roflumilast Roflumilast may decrease the excretion rate of Macitentan which could result in a higher serum level.
Rivaroxaban Rivaroxaban Rivaroxaban may decrease the excretion rate of Macitentan which could result in a higher serum level.
Ruxolitinib Ruxolitinib Ruxolitinib may decrease the excretion rate of Macitentan which could result in a higher serum level.
Clobazam Clobazam Clobazam may decrease the excretion rate of Macitentan which could result in a higher serum level.
Deferiprone Deferiprone Deferiprone may decrease the excretion rate of Macitentan which could result in a higher serum level.
Cabergoline Cabergoline Cabergoline may decrease the antihypertensive activities of Macitentan.
Naloxone Injection Naloxone Injection Naloxone may decrease the excretion rate of Macitentan which could result in a higher serum level.
Ambrisentan Ambrisentan Ambrisentan may increase the hypotensive activities of Macitentan.
Fondaparinux Injection Fondaparinux Injection Fondaparinux may decrease the excretion rate of Macitentan which could result in a higher serum level.
Iloprost Iloprost Iloprost may increase the hypotensive activities of Macitentan.
Enzalutamide Enzalutamide Enzalutamide may decrease the excretion rate of Macitentan which could result in a higher serum level.
Mirabegron Mirabegron Mirabegron may decrease the excretion rate of Macitentan which could result in a higher serum level.
Teduglutide Injection Teduglutide Injection Teduglutide may decrease the excretion rate of Macitentan which could result in a higher serum level.
Alogliptin Alogliptin Alogliptin may decrease the excretion rate of Macitentan which could result in a higher serum level.
Pomalidomide Pomalidomide Pomalidomide may decrease the excretion rate of Macitentan which could result in a higher serum level.
Canagliflozin Canagliflozin Canagliflozin may increase the excretion rate of Macitentan which could result in a lower serum level and potentially a reduction in efficacy.
Methazolamide Methazolamide Methazolamide may increase the excretion rate of Macitentan which could result in a lower serum level and potentially a reduction in efficacy.
Trametinib Trametinib Trametinib may decrease the excretion rate of Macitentan which could result in a higher serum level.
Levomilnacipran Levomilnacipran Levomilnacipran may decrease the excretion rate of Macitentan which could result in a higher serum level.
Ertapenem Injection Ertapenem Injection Ertapenem may decrease the excretion rate of Macitentan which could result in a higher serum level.
Vortioxetine Vortioxetine Macitentan may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Avanafil Avanafil Avanafil may increase the antihypertensive activities of Macitentan.
Ketorolac Injection Ketorolac Injection The therapeutic efficacy of Macitentan can be decreased when used in combination with Ketorolac.
Obinutuzumab Injection Obinutuzumab Injection Macitentan may increase the hypotensive activities of Obinutuzumab.
Sofosbuvir Sofosbuvir Macitentan may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin Dapagliflozin Dapagliflozin may increase the excretion rate of Macitentan which could result in a lower serum level and potentially a reduction in efficacy.
Apremilast Apremilast Apremilast may decrease the excretion rate of Macitentan which could result in a higher serum level.
Droxidopa Droxidopa Droxidopa may decrease the excretion rate of Macitentan which could result in a higher serum level.
Testosterone Injection Testosterone Injection Testosterone may decrease the excretion rate of Macitentan which could result in a higher serum level.
Empagliflozin Empagliflozin Empagliflozin may increase the hypotensive activities of Macitentan.
Edoxaban Edoxaban Macitentan may decrease the excretion rate of Edoxaban which could result in a higher serum level.
Methamphetamine Methamphetamine Metamfetamine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Tasimelteon Tasimelteon Macitentan may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Riociguat Riociguat Riociguat may increase the hypotensive activities of Macitentan.
Risperidone Injection Risperidone Injection Risperidone may decrease the antihypertensive activities of Macitentan.
Dinutuximab Injection Dinutuximab Injection Dinutuximab may increase the hypotensive activities of Macitentan.
Haloperidol Injection Haloperidol Injection The serum concentration of Macitentan can be increased when it is combined with Haloperidol.
Amiloride Amiloride Amiloride may increase the excretion rate of Macitentan which could result in a lower serum level and potentially a reduction in efficacy.
Flibanserin Flibanserin Flibanserin may decrease the antihypertensive activities of Macitentan.
Brexpiprazole Brexpiprazole Brexpiprazole may decrease the antihypertensive activities of Macitentan.
Ziprasidone Injection Ziprasidone Injection Ziprasidone may increase the antihypertensive activities of Macitentan.
Cariprazine Cariprazine Cariprazine may decrease the antihypertensive activities of Macitentan.
Penicillin G Procaine Injection Penicillin G Procaine Injection Macitentan may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Ixazomib Ixazomib Macitentan may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Lesinurad Lesinurad Macitentan may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Macitentan which could result in a higher serum level.
Brivaracetam Injection Brivaracetam Injection Brivaracetam may decrease the excretion rate of Macitentan which could result in a higher serum level.
Midodrine Midodrine Midodrine may decrease the antihypertensive activities of Macitentan.
Selexipag Selexipag Macitentan may increase the hypotensive activities of Selexipag.
Furosemide Injection Furosemide Injection Furosemide may increase the excretion rate of Macitentan which could result in a lower serum level and potentially a reduction in efficacy.
Lixisenatide Injection Lixisenatide Injection Macitentan may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Doxepin (Insomnia) Doxepin (Insomnia) Doxepin may decrease the excretion rate of Macitentan which could result in a higher serum level.
Deutetrabenazine Deutetrabenazine Macitentan may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level.
Valbenazine Valbenazine Macitentan may decrease the excretion rate of Valbenazine which could result in a higher serum level.
Safinamide Safinamide Safinamide may increase the hypotensive activities of Macitentan.
Naldemedine Naldemedine Macitentan may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Benznidazole Benznidazole Macitentan may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Delafloxacin Delafloxacin Macitentan may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Ertugliflozin Ertugliflozin Ertugliflozin may increase the excretion rate of Macitentan which could result in a lower serum level and potentially a reduction in efficacy.
Apalutamide Apalutamide Macitentan may decrease the excretion rate of Apalutamide which could result in a higher serum level.
Fostamatinib Fostamatinib Fostamatinib may increase the antihypertensive activities of Macitentan.
Baricitinib Baricitinib Macitentan may decrease the excretion rate of Baricitinib which could result in a higher serum level.
Lofexidine Lofexidine Lofexidine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Plazomicin Injection Plazomicin Injection Macitentan may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Cannabidiol Cannabidiol Cannabidiol may decrease the antihypertensive activities of Macitentan.
Stiripentol Stiripentol Macitentan may decrease the excretion rate of Stiripentol which could result in a higher serum level.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection Paclitaxel may increase the hypotensive activities of Macitentan.
Prucalopride Prucalopride Prucalopride may decrease the excretion rate of Macitentan which could result in a higher serum level.
Siponimod Siponimod Siponimod may decrease the antihypertensive activities of Macitentan.
Acyclovir Ophthalmic Acyclovir Ophthalmic Acyclovir may decrease the excretion rate of Macitentan which could result in a higher serum level.
Solriamfetol Solriamfetol Macitentan may decrease the excretion rate of Solriamfetol which could result in a higher serum level.
Pitolisant Pitolisant The serum concentration of Macitentan can be decreased when it is combined with Pitolisant.
Cenobamate Cenobamate The serum concentration of Macitentan can be decreased when it is combined with Cenobamate.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Macitentan.
Selpercatinib Selpercatinib Selpercatinib may decrease the antihypertensive activities of Macitentan.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Macitentan can be decreased when it is combined with Satralizumab.
Naxitamab-gqgk Injection Naxitamab-gqgk Injection Naxitamab may decrease the antihypertensive activities of Macitentan.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives Drospirenone may increase the excretion rate of Macitentan which could result in a lower serum level and potentially a reduction in efficacy.
Viloxazine Viloxazine Macitentan may decrease the excretion rate of Viloxazine which could result in a higher serum level.
Tobramycin Injection Tobramycin Injection Tobramycin may decrease the excretion rate of Macitentan which could result in a higher serum level.
Fenoprofen Fenoprofen The therapeutic efficacy of Macitentan can be decreased when used in combination with Fenoprofen.
Indomethacin Indomethacin The therapeutic efficacy of Macitentan can be decreased when used in combination with Indomethacin.
Mefenamic Acid Mefenamic Acid The therapeutic efficacy of Macitentan can be decreased when used in combination with Mefenamic acid.
Naproxen Naproxen The therapeutic efficacy of Macitentan can be decreased when used in combination with Naproxen.
Tolmetin Tolmetin The therapeutic efficacy of Macitentan can be decreased when used in combination with Tolmetin.
Sulindac Sulindac The therapeutic efficacy of Macitentan can be decreased when used in combination with Sulindac.
Trazodone Trazodone Trazodone may decrease the antihypertensive activities of Macitentan.
Isotretinoin Isotretinoin Isotretinoin may decrease the excretion rate of Macitentan which could result in a higher serum level.
Sucralfate Sucralfate Sucralfate may decrease the excretion rate of Macitentan which could result in a higher serum level.
Floxuridine Floxuridine Floxuridine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Metaxalone Metaxalone Metaxalone may decrease the excretion rate of Macitentan which could result in a higher serum level.
Methotrexate Injection Methotrexate Injection Methotrexate may decrease the excretion rate of Macitentan which could result in a higher serum level.
Diethylpropion Diethylpropion Diethylpropion may decrease the antihypertensive activities of Macitentan.
Chlorpromazine Chlorpromazine Chlorpromazine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Diazepam Diazepam Diazepam may decrease the excretion rate of Macitentan which could result in a higher serum level.
Oxazepam Oxazepam Oxazepam may decrease the excretion rate of Macitentan which could result in a higher serum level.
Flurazepam Flurazepam Flurazepam may decrease the excretion rate of Macitentan which could result in a higher serum level.
Clorazepate Clorazepate Clorazepic acid may decrease the excretion rate of Macitentan which could result in a higher serum level.
Lorazepam Lorazepam Lorazepam may decrease the excretion rate of Macitentan which could result in a higher serum level.
Phenoxybenzamine Phenoxybenzamine Phenoxybenzamine may decrease the antihypertensive activities of Macitentan.
Carmustine Carmustine Carmustine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Amantadine Amantadine Amantadine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Codeine Codeine Codeine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Bromocriptine Bromocriptine Bromocriptine may decrease the antihypertensive activities of Macitentan.
Metaproterenol Metaproterenol Orciprenaline may decrease the antihypertensive activities of Macitentan.
Tranylcypromine Tranylcypromine Tranylcypromine may increase the hypotensive activities of Macitentan.
Phenelzine Phenelzine Phenelzine may increase the hypotensive activities of Macitentan.
Procarbazine Procarbazine Procarbazine may increase the hypotensive activities of Macitentan.
Ergoloid Mesylates Ergoloid Mesylates Ergoloid mesylate may decrease the antihypertensive activities of Macitentan.
Tetracycline Tetracycline Tetracycline may decrease the excretion rate of Macitentan which could result in a higher serum level.
Thioridazine Thioridazine Thioridazine may decrease the antihypertensive activities of Macitentan.
Trifluoperazine Trifluoperazine Trifluoperazine may decrease the antihypertensive activities of Macitentan.
Bleomycin Bleomycin Bleomycin may decrease the excretion rate of Macitentan which could result in a higher serum level.
Sulfadiazine Sulfadiazine Sulfadiazine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Methadone Methadone Methadone may decrease the excretion rate of Macitentan which could result in a higher serum level.
Benztropine Benztropine Benzatropine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Maprotiline Maprotiline Maprotiline may decrease the excretion rate of Macitentan which could result in a higher serum level.
Ibuprofen Ibuprofen The therapeutic efficacy of Macitentan can be decreased when used in combination with Ibuprofen.
Azathioprine Azathioprine Azathioprine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Phentermine Phentermine Phentermine may decrease the antihypertensive activities of Macitentan.
Methylphenidate Methylphenidate Methylphenidate may decrease the antihypertensive activities of Macitentan.
Amoxapine Amoxapine Amoxapine may decrease the antihypertensive activities of Macitentan.
Sulfasalazine Sulfasalazine The therapeutic efficacy of Macitentan can be decreased when used in combination with Sulfasalazine.
Phenazopyridine Phenazopyridine Phenazopyridine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Carbamazepine Carbamazepine Carbamazepine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Methyldopa Methyldopa Methyldopa may decrease the excretion rate of Macitentan which could result in a higher serum level.
Clonidine Clonidine The risk or severity of hypotension can be increased when Clonidine is combined with Macitentan.
Prazosin Prazosin The risk or severity of hypotension can be increased when Prazosin is combined with Macitentan.
Hydralazine Hydralazine Hydralazine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Cimetidine Cimetidine Cimetidine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Gentamicin Injection Gentamicin Injection Gentamicin may decrease the excretion rate of Macitentan which could result in a higher serum level.
Warfarin Warfarin Warfarin may decrease the excretion rate of Macitentan which could result in a higher serum level.
Clonazepam Clonazepam Clonazepam may decrease the excretion rate of Macitentan which could result in a higher serum level.
Promethazine Promethazine Promethazine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Meclofenamate Meclofenamate The therapeutic efficacy of Macitentan can be decreased when used in combination with Meclofenamic acid.
Nitrofurantoin Nitrofurantoin Nitrofurantoin may decrease the excretion rate of Macitentan which could result in a higher serum level.
Digoxin Digoxin Macitentan may decrease the excretion rate of Digoxin which could result in a higher serum level.
Chloroquine Chloroquine Chloroquine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Quinine Quinine Quinine may increase the hypotensive activities of Macitentan.
Triamterene Triamterene Triamterene may decrease the excretion rate of Macitentan which could result in a higher serum level.
Chlorothiazide Chlorothiazide The therapeutic efficacy of Macitentan can be increased when used in combination with Chlorothiazide.
Chlorthalidone Chlorthalidone Chlorthalidone may increase the excretion rate of Macitentan which could result in a lower serum level and potentially a reduction in efficacy.
Metolazone Metolazone Metolazone may increase the excretion rate of Macitentan which could result in a lower serum level and potentially a reduction in efficacy.
Isosorbide Isosorbide Isosorbide may increase the excretion rate of Macitentan which could result in a lower serum level and potentially a reduction in efficacy.
Secobarbital Secobarbital Secobarbital may decrease the excretion rate of Macitentan which could result in a higher serum level.
Desipramine Desipramine Desipramine may decrease the antihypertensive activities of Macitentan.
Amitriptyline Amitriptyline Amitriptyline may decrease the excretion rate of Macitentan which could result in a higher serum level.
Imipramine Imipramine Imipramine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Probenecid Probenecid Probenecid may decrease the excretion rate of Macitentan which could result in a higher serum level.
Quinidine Quinidine Quinidine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Procainamide Procainamide Macitentan may decrease the excretion rate of Procainamide which could result in a higher serum level.
Isoniazid Isoniazid Isoniazid may decrease the excretion rate of Macitentan which could result in a higher serum level.
Pyrazinamide Pyrazinamide Pyrazinamide may decrease the excretion rate of Macitentan which could result in a higher serum level.
Disopyramide Disopyramide Disopyramide may decrease the excretion rate of Macitentan which could result in a higher serum level.
Butabarbital Butabarbital Butabarbital may decrease the excretion rate of Macitentan which could result in a higher serum level.
Liothyronine Liothyronine Liothyronine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Methimazole Methimazole Methimazole may decrease the excretion rate of Macitentan which could result in a higher serum level.
Chlorpropamide Chlorpropamide Chlorpropamide may decrease the excretion rate of Macitentan which could result in a higher serum level.
Tolbutamide Tolbutamide Tolbutamide may decrease the excretion rate of Macitentan which could result in a higher serum level.
Tolazamide Tolazamide Tolazamide may decrease the excretion rate of Macitentan which could result in a higher serum level.
Baclofen Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Macitentan.
Ethambutol Ethambutol Ethambutol may decrease the excretion rate of Macitentan which could result in a higher serum level.
Methyclothiazide Methyclothiazide The therapeutic efficacy of Macitentan can be increased when used in combination with Methyclothiazide.
Hydrochlorothiazide Hydrochlorothiazide The therapeutic efficacy of Macitentan can be increased when used in combination with Hydrochlorothiazide.
Chlorzoxazone Chlorzoxazone Chlorzoxazone may decrease the excretion rate of Macitentan which could result in a higher serum level.
Pyridoxine Pyridoxine Pyridoxine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Folic Acid Folic Acid Folic acid may decrease the excretion rate of Macitentan which could result in a higher serum level.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) Propranolol may decrease the excretion rate of Macitentan which could result in a higher serum level.
Minoxidil Minoxidil Minoxidil may increase the hypotensive activities of Macitentan.
Pseudoephedrine Pseudoephedrine Pseudoephedrine may decrease the antihypertensive activities of Macitentan.
Nortriptyline Nortriptyline Nortriptyline may decrease the antihypertensive activities of Macitentan.
Spironolactone Spironolactone Spironolactone may increase the excretion rate of Macitentan which could result in a lower serum level and potentially a reduction in efficacy.
Amphotericin B Injection Amphotericin B Injection Amphotericin B may decrease the excretion rate of Macitentan which could result in a higher serum level.
Phytonadione Phytonadione Phylloquinone may decrease the excretion rate of Macitentan which could result in a higher serum level.
Amikacin Injection Amikacin Injection Amikacin may decrease the excretion rate of Macitentan which could result in a higher serum level.
Nadolol Nadolol Nadolol may decrease the excretion rate of Macitentan which could result in a higher serum level.
Allopurinol Allopurinol Allopurinol may decrease the excretion rate of Macitentan which could result in a higher serum level.
Flavoxate Flavoxate Flavoxate may decrease the excretion rate of Macitentan which could result in a higher serum level.
Papaverine Papaverine Papaverine may increase the hypotensive activities of Macitentan.
Colchicine Colchicine Colchicine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Cefaclor Cefaclor Cefaclor may decrease the excretion rate of Macitentan which could result in a higher serum level.
Cefadroxil Cefadroxil Cefadroxil may decrease the excretion rate of Macitentan which could result in a higher serum level.
Cefazolin Injection Cefazolin Injection Cefazolin may decrease the excretion rate of Macitentan which could result in a higher serum level.
Cephalexin Cephalexin Cephalexin may decrease the excretion rate of Macitentan which could result in a higher serum level.
Cefoxitin Injection Cefoxitin Injection Cefoxitin may decrease the excretion rate of Macitentan which could result in a higher serum level.
Dacarbazine Dacarbazine Dacarbazine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Acetazolamide Acetazolamide Acetazolamide may increase the excretion rate of Macitentan which could result in a lower serum level and potentially a reduction in efficacy.
Cefotaxime Injection Cefotaxime Injection Cefotaxime may decrease the excretion rate of Macitentan which could result in a higher serum level.
Calcitonin Salmon Injection Calcitonin Salmon Injection Salmon calcitonin may decrease the excretion rate of Macitentan which could result in a higher serum level.
Pyrantel Pyrantel Macitentan may decrease the excretion rate of Pyrantel which could result in a higher serum level.
Captopril Captopril Captopril may increase the hypotensive activities of Macitentan.
Dipyridamole Dipyridamole Dipyridamole may increase the antihypertensive activities of Macitentan.
Isoxsuprine Isoxsuprine Isoxsuprine may decrease the antihypertensive activities of Macitentan.
Ethacrynic Acid Ethacrynic Acid Etacrynic acid may decrease the excretion rate of Macitentan which could result in a higher serum level.
Colistimethate Injection Colistimethate Injection Colistimethate may decrease the excretion rate of Macitentan which could result in a higher serum level.
Metoprolol Metoprolol Metoprolol may decrease the excretion rate of Macitentan which could result in a higher serum level.
Aspirin Aspirin Acetylsalicylic acid may decrease the excretion rate of Macitentan which could result in a higher serum level.
Salsalate Salsalate The therapeutic efficacy of Macitentan can be decreased when used in combination with Salsalate.
Alprazolam Alprazolam Alprazolam may decrease the excretion rate of Macitentan which could result in a higher serum level.
Temazepam Temazepam Temazepam may decrease the excretion rate of Macitentan which could result in a higher serum level.
Triazolam Triazolam Triazolam may decrease the excretion rate of Macitentan which could result in a higher serum level.
Dicyclomine Dicyclomine Dicyclomine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Propantheline Propantheline Propantheline may decrease the excretion rate of Macitentan which could result in a higher serum level.
Trimethoprim Trimethoprim Trimethoprim may decrease the excretion rate of Macitentan which could result in a higher serum level.
Diltiazem Diltiazem Diltiazem may increase the hypotensive activities of Macitentan.
Nifedipine Nifedipine Nifedipine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Timolol Timolol Timolol may decrease the excretion rate of Macitentan which could result in a higher serum level.
Verapamil Verapamil Verapamil may decrease the excretion rate of Macitentan which could result in a higher serum level.
Atenolol Atenolol Atenolol may increase the hypotensive activities of Macitentan.
Pindolol Pindolol Pindolol may decrease the excretion rate of Macitentan which could result in a higher serum level.
Cisplatin Injection Cisplatin Injection Macitentan may decrease the excretion rate of Cisplatin which could result in a higher serum level.
Diflunisal Diflunisal The therapeutic efficacy of Macitentan can be decreased when used in combination with Diflunisal.
Piroxicam Piroxicam The therapeutic efficacy of Macitentan can be decreased when used in combination with Piroxicam.
Bumetanide Bumetanide Bumetanide may increase the excretion rate of Macitentan which could result in a lower serum level and potentially a reduction in efficacy.
Glipizide Glipizide Glipizide may decrease the excretion rate of Macitentan which could result in a higher serum level.
Indapamide Indapamide The therapeutic efficacy of Macitentan can be increased when used in combination with Indapamide.
Amoxicillin Amoxicillin Amoxicillin may decrease the excretion rate of Macitentan which could result in a higher serum level.
Oxacillin Injection Oxacillin Injection Oxacillin may decrease the excretion rate of Macitentan which could result in a higher serum level.
Pentoxifylline Pentoxifylline Pentoxifylline may increase the hypotensive activities of Macitentan.
Pentamidine Injection Pentamidine Injection Pentamidine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Ceftriaxone Injection Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Macitentan which could result in a higher serum level.
Labetalol Labetalol Labetalol may decrease the excretion rate of Macitentan which could result in a higher serum level.
Auranofin Auranofin Auranofin may decrease the excretion rate of Macitentan which could result in a higher serum level.
Leuprolide Injection Leuprolide Injection Leuprolide may decrease the excretion rate of Macitentan which could result in a higher serum level.
Gemfibrozil Gemfibrozil Gemfibrozil may decrease the excretion rate of Macitentan which could result in a higher serum level.
Guanabenz Guanabenz Guanabenz may increase the hypotensive activities of Macitentan.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Macitentan which could result in a higher serum level.
Ceftazidime Injection Ceftazidime Injection Ceftazidime may decrease the excretion rate of Macitentan which could result in a higher serum level.
Ketoprofen Ketoprofen The therapeutic efficacy of Macitentan can be decreased when used in combination with Ketoprofen.
Cefotetan Injection Cefotetan Injection Cefotetan may decrease the excretion rate of Macitentan which could result in a higher serum level.
Enalapril Enalapril Enalapril may increase the hypotensive activities of Macitentan.
Flurbiprofen Flurbiprofen The therapeutic efficacy of Macitentan can be decreased when used in combination with Flurbiprofen.
Amiodarone Amiodarone Amiodarone may increase the hypotensive activities of Macitentan.
Aztreonam Injection Aztreonam Injection Aztreonam may decrease the excretion rate of Macitentan which could result in a higher serum level.
Buspirone Buspirone Buspirone may decrease the excretion rate of Macitentan which could result in a higher serum level.
Ciprofloxacin Ciprofloxacin Ciprofloxacin may decrease the excretion rate of Macitentan which could result in a higher serum level.
Mesalamine Mesalamine The therapeutic efficacy of Macitentan can be decreased when used in combination with Mesalazine.
Diclofenac Diclofenac The therapeutic efficacy of Macitentan can be decreased when used in combination with Diclofenac.
Nimodipine Nimodipine Nimodipine may increase the hypotensive activities of Macitentan.
Clozapine Clozapine Clozapine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Estazolam Estazolam Estazolam may decrease the excretion rate of Macitentan which could result in a higher serum level.
Didanosine Didanosine Didanosine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Pentostatin Injection Pentostatin Injection Pentostatin may decrease the excretion rate of Macitentan which could result in a higher serum level.
Benazepril Benazepril Benazepril may increase the hypotensive activities of Macitentan.
Etodolac Etodolac The therapeutic efficacy of Macitentan can be decreased when used in combination with Etodolac.
Felodipine Felodipine Felodipine may increase the hypotensive activities of Macitentan.
Fosinopril Fosinopril Fosinopril may decrease the excretion rate of Macitentan which could result in a higher serum level.
Nabumetone Nabumetone The therapeutic efficacy of Macitentan can be decreased when used in combination with Nabumetone.
Quinapril Quinapril Quinapril may increase the hypotensive activities of Macitentan.
Ramipril Ramipril Ramipril may increase the hypotensive activities of Macitentan.
Amlodipine Amlodipine Amlodipine may increase the hypotensive activities of Macitentan.
Lisinopril Lisinopril Lisinopril may decrease the excretion rate of Macitentan which could result in a higher serum level.
Oxaprozin Oxaprozin The therapeutic efficacy of Macitentan can be decreased when used in combination with Oxaprozin.
Sotalol Sotalol Sotalol may increase the hypotensive activities of Macitentan.
Bisoprolol Bisoprolol Bisoprolol may decrease the excretion rate of Macitentan which could result in a higher serum level.
Doxazosin Doxazosin Doxazosin may increase the hypotensive activities of Macitentan.
Terazosin Terazosin Terazosin may increase the hypotensive activities of Macitentan.
Isradipine Isradipine Isradipine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Venlafaxine Venlafaxine Venlafaxine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Fluvoxamine Fluvoxamine Fluvoxamine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Nefazodone Nefazodone Nefazodone may decrease the excretion rate of Macitentan which could result in a higher serum level.
Lamotrigine Lamotrigine Lamotrigine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Losartan Losartan Losartan may increase the hypotensive activities of Macitentan.
Valacyclovir Valacyclovir Valaciclovir may decrease the excretion rate of Macitentan which could result in a higher serum level.
Tramadol Tramadol Tramadol may decrease the excretion rate of Macitentan which could result in a higher serum level.
Carboplatin Injection Carboplatin Injection Carboplatin may decrease the excretion rate of Macitentan which could result in a higher serum level.
Moexipril Moexipril Moexipril may increase the hypotensive activities of Macitentan.
Ifosfamide Injection Ifosfamide Injection Ifosfamide may decrease the excretion rate of Macitentan which could result in a higher serum level.
Nicardipine Nicardipine Nicardipine may increase the hypotensive activities of Macitentan.
Bupropion Bupropion Bupropion may decrease the excretion rate of Macitentan which could result in a higher serum level.
Ticlopidine Ticlopidine Ticlopidine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Metformin Metformin Metformin may decrease the excretion rate of Macitentan which could result in a higher serum level.
Nisoldipine Nisoldipine Nisoldipine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Lamivudine Lamivudine Lamivudine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Amifostine Injection Amifostine Injection Macitentan may increase the hypotensive activities of Amifostine.
Acarbose Acarbose Acarbose may decrease the excretion rate of Macitentan which could result in a higher serum level.
Gemcitabine Injection Gemcitabine Injection Gemcitabine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Ritonavir Ritonavir The serum concentration of Macitentan can be increased when it is combined with Ritonavir.
Cidofovir Injection Cidofovir Injection Cidofovir may decrease the excretion rate of Macitentan which could result in a higher serum level.
Meropenem Injection Meropenem Injection Meropenem may decrease the excretion rate of Macitentan which could result in a higher serum level.
Clomipramine Clomipramine Clomipramine may decrease the antihypertensive activities of Macitentan.
Fosfomycin Fosfomycin Fosfomycin may decrease the excretion rate of Macitentan which could result in a higher serum level.
Mirtazapine Mirtazapine Mirtazapine may decrease the antihypertensive activities of Macitentan.
Trandolapril Trandolapril Trandolapril may increase the hypotensive activities of Macitentan.
Topiramate Topiramate Topiramate may decrease the excretion rate of Macitentan which could result in a higher serum level.
Valsartan Valsartan Valsartan may increase the hypotensive activities of Macitentan.
Pramipexole Pramipexole Pramipexole may decrease the excretion rate of Macitentan which could result in a higher serum level.
Carvedilol Carvedilol Carvedilol may increase the hypotensive activities of Macitentan.
Nilutamide Nilutamide Nilutamide may decrease the excretion rate of Macitentan which could result in a higher serum level.
Flutamide Flutamide Flutamide may decrease the excretion rate of Macitentan which could result in a higher serum level.
Selegiline Selegiline Selegiline may increase the hypotensive activities of Macitentan.
Propafenone Propafenone Propafenone may decrease the antihypertensive activities of Macitentan.
Irbesartan Irbesartan Irbesartan may increase the hypotensive activities of Macitentan.
Tamsulosin Tamsulosin Tamsulosin may decrease the excretion rate of Macitentan which could result in a higher serum level.
Ropinirole Ropinirole Ropinirole may increase the hypotensive activities of Macitentan.
Finasteride Finasteride Finasteride may decrease the antihypertensive activities of Macitentan.
Quetiapine Quetiapine Quetiapine may increase the hypotensive activities of Macitentan.
Cefepime Injection Cefepime Injection Cefepime may decrease the excretion rate of Macitentan which could result in a higher serum level.
Cefprozil Cefprozil Cefprozil may decrease the excretion rate of Macitentan which could result in a higher serum level.
Cefpodoxime Cefpodoxime Cefpodoxime may decrease the excretion rate of Macitentan which could result in a higher serum level.
Cetirizine Cetirizine Cetirizine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Tolcapone Tolcapone Tolcapone may decrease the excretion rate of Macitentan which could result in a higher serum level.
Capecitabine Capecitabine Capecitabine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Abacavir Abacavir Abacavir may decrease the excretion rate of Macitentan which could result in a higher serum level.
Sildenafil Sildenafil Sildenafil may increase the antihypertensive activities of Macitentan.
Celecoxib Celecoxib The therapeutic efficacy of Macitentan can be decreased when used in combination with Celecoxib.
Rosiglitazone Rosiglitazone Rosiglitazone may decrease the excretion rate of Macitentan which could result in a higher serum level.
Tolterodine Tolterodine Tolterodine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Thalidomide Thalidomide Thalidomide may increase the hypotensive activities of Macitentan.
Oseltamivir Oseltamivir Oseltamivir may decrease the excretion rate of Macitentan which could result in a higher serum level.
Balsalazide Balsalazide The therapeutic efficacy of Macitentan can be decreased when used in combination with Balsalazide.
Nateglinide Nateglinide Nateglinide may decrease the excretion rate of Macitentan which could result in a higher serum level.
Rabeprazole Rabeprazole Rabeprazole may decrease the excretion rate of Macitentan which could result in a higher serum level.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists

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