Macitentan
Generic name: Pronounced as (ma'' si ten' tan)
Medical Content Reviewed By HelloPharmacist Staff
Last Revised - 01/15/2019
On this page
- Why is this medication prescribed?
- How should this medicine be used?
- Other uses for this medicine
- What special precautions should I follow?
- What special dietary instructions should I follow?
- What should I do if I forget a dose?
- What side effects can this medication cause?
- What should I know about STORAGE and DISPOSAL of this medication?
- What should I do in case of OVERDOSE?
- What OTHER INFORMATION should I know?
- Drug interactions
IMPORTANT WARNING
For female patients:
Do not take macitentan if you are pregnant or plan to become pregnant. There is a high risk that macitentan will cause harm to the fetus.
Because of the risk of fetal harm, a program called OPSUMIT Risk Evaluation and Mitigation Strategy (OPSUMIT REMS) has been set up to make sure that pregnant woman do not take macitentan, and that woman do not become pregnant while taking macitentan. All females, including females who are not able to get pregnant, can only receive macitentan if they are registered with OPSUMIT REMS, have a prescription from a doctor who is registered with OPSUMIT REMS, and fill the prescription at a pharmacy that is registered with OPSUMIT REMS.
Your doctor will register you in OPSUMIT REMS. Your doctor will tell you about the risks of macitentan, especially the risks of serious birth defects if taken while pregnant. You must sign an informed consent sheet stating that you understand this information in order for your doctor to register you.
Your doctor will also determine if you are able to become pregnant. If you have reached puberty (when child's body becomes physically mature and capable of having a child), have a uterus, and have not yet gone through menopause ('change in life' end of monthly menstrual periods) you are considered to be a female who is able to become pregnant, and you will have to follow certain additional rules in order to receive macitentan.
For females who are able to become pregnant:
You must use reliable birth control throughout your treatment with macitentan, and for 1 month after your final dose. Your doctor will tell you which forms of birth control are acceptable, and will give your written information about birth control. In most cases you will be required to use two forms of birth control in order to prevent pregnancy while taking macitentan.
You will have to take a pregnancy test before starting treatment, every month during treatment, and 1 month after your final dose in order to be able to receive macitentan. Your doctor will order the pregnancy tests for you. The pharmacy will not dispense macitentan to you until they have confirmed that you have taken your required pregnancy tests.
You must not have unprotected sex while taking macitentan.
Call your doctor right away if you have had unprotected sex, think your birth control failed, missed your period, or think you may be pregnant for any reason. He will discuss your medical options with you. Do not wait until your next appointment to discuss this with your doctor.
Tell your doctor if you do not understand everything you were told about birth control, or if you do not think you will be able to use acceptable forms of birth control at all times during your treatment.
If you are a parent or guardian of a female who had not yet reached puberty, check your child regularly to see if she is developing any signs of puberty (breast buds, pubic hair )and let her doctor know about any changes.
For all patients:
Macitentan is not available at retail pharmacies. Your medication will be mailed to you from a specialty pharmacy that is registered with OPSUMIT REMS. If you are a female who has not reached puberty or a female who is able to become pregnant you will only receive a 30 day supply at a time. Ask your doctor if you have any questions about how you will receive your medication.
Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with macitentan and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide.
Why is this medication prescribed?
Macitentan is used to manage the symptoms of pulmonary arterial hypertension (PAH; high blood pressure in the vessels that carry blood to the lungs). Macitentan is in a class of medications called endothelin receptor antagonists. It works by stopping the action of endothelin, a natural substance that causes blood vessels to narrow and prevents normal blood flow in people who have PAH.
How should this medicine be used?
Macitentan comes as a tablet to take by mouth. It is usually taken with or without food once a day. Take macitentan at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take macitentan exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Swallow the tablets whole; do not split, chew, or crush them.
Other uses for this medicine
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What special precautions should I follow?
Before taking macitentan,
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tell your doctor and pharmacist if you are allergic to macitentan, any other medications, or any of the ingredients in macitentan tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
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tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: carbamazepine (Carbatrol, Epitol, Equetro, Tegretol), clarithromycin (Biaxin, in Prevpac); efavirenz (Sustiva); certain HIV protease inhibitors such as nelfinavir (Viracept), indinavir (Crixivan), and ritonavir (Norvir, in Kaletra); itraconazole (Onmel, Sporanox); ketoconazole; nefazodone; nevirapine Viramune); phenobarbital; phenytoin (Dilantin, Phenytek); rifabutin (Mycobutin); and rifampin (Rifadin, Rifamate, Rifater, Rimactane). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with macitentan, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
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tell your doctor what herbal products you are taking, especially St. John's wort.
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tell your doctor if you have or have ever had anemia (condition in which red blood cells do not bring enough oxygen to the organs) or liver disease.
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do not breastfeed while taking this medication.
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you should know that this medication may decrease fertility in men. Talk to your doctor about the risks of taking macitentan.
What special dietary instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
What should I do if I forget a dose?
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can this medication cause?
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Macitentan may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
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stuffy nose
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sore throat
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cough
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flu like symptoms
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headache
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urgent, frequent, or painful urination
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rash
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Some side effects can be serious. If you experience any of these symptoms, stop taking macitentan and call your doctor immediately or get emergency medical treatment:
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itchy skin
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dark urine
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yellowing of your skin or eyes
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pain in the upper right part of your stomach
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unexplained nausea or vomiting
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loss of appetite
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extreme tiredness
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fever
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swelling of the face, throat, tongue, lips, and eyes
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difficulty swallowing or breathing
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hoarseness
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shortness of breath, especially when lying down
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coughing up pink, frothy sputum or blood
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unusual weight increase
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swelling of the ankles or legs
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Macitentan may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
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If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
What should I know about STORAGE and DISPOSAL of this medication?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).
It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.
What should I do in case of OVERDOSE?
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
Symptoms of overdose may include:
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headache
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nausea
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vomiting
What OTHER INFORMATION should I know?
Keep all appointments with your doctor and the laboratory. Your doctor may order tests to see how well your liver is working, and to check for anemia before starting treatment and from time to time during your treatment with macitentan.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Drug interactions
Drug | Interaction |
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Candesartan | Candesartan Macitentan may increase the hypotensive activities of Candesartan. |
Cilostazol | Cilostazol Cilostazol may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Estrogen and Progestin (Oral Contraceptives) | Estrogen and Progestin (Oral Contraceptives) Conjugated estrogens may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Fenofibrate | Fenofibrate Fenofibrate may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Guanfacine | Guanfacine Guanfacine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Magnesium Hydroxide | Magnesium Hydroxide Macitentan may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level. |
Methylergonovine | Methylergonovine Methylergometrine may decrease the antihypertensive activities of Macitentan. |
Mycophenolate | Mycophenolate Mycophenolic acid may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Naratriptan | Naratriptan Naratriptan may decrease the antihypertensive activities of Macitentan. |
Olsalazine | Olsalazine The therapeutic efficacy of Macitentan can be decreased when used in combination with Olsalazine. |
Paregoric | Paregoric Morphine may increase the hypotensive activities of Macitentan. |
Penbutolol | Penbutolol Acebutolol may increase the hypotensive activities of Macitentan. |
Potassium | Potassium Potassium cation may increase the excretion rate of Macitentan which could result in a lower serum level and potentially a reduction in efficacy. |
Prednisone | Prednisone Prednisone may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Ranitidine | Ranitidine Ranitidine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Reserpine | Reserpine Reserpine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Rizatriptan | Rizatriptan Rizatriptan may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Sumatriptan | Sumatriptan Sumatriptan may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Tacrolimus | Tacrolimus Tacrolimus may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Tizanidine | Tizanidine Tizanidine may increase the hypotensive activities of Macitentan. |
Zolmitriptan | Zolmitriptan Zolmitriptan may decrease the antihypertensive activities of Macitentan. |
Ampicillin Injection | Ampicillin Injection Ampicillin may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Doxycycline Injection | Doxycycline Injection Doxycycline may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Fluconazole Injection | Fluconazole Injection Fluconazole may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Foscarnet Injection | Foscarnet Injection Foscarnet may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Hydromorphone Injection | Hydromorphone Injection Hydromorphone may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Levofloxacin Injection | Levofloxacin Injection Levofloxacin may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Meperidine Injection | Meperidine Injection Meperidine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Metoclopramide Injection | Metoclopramide Injection Metoclopramide may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Morphine Injection | Morphine Injection Morphine may increase the hypotensive activities of Macitentan. |
Pamidronate Injection | Pamidronate Injection Pamidronic acid may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Vancomycin Injection | Vancomycin Injection Macitentan may decrease the excretion rate of Vancomycin which could result in a higher serum level. |
Altretamine | Altretamine Amphetamine may increase the hypotensive activities of Macitentan. |
Cefuroxime | Cefuroxime Cefuroxime may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Cyclosporine | Cyclosporine Cyclosporine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Torsemide | Torsemide Torasemide may increase the excretion rate of Macitentan which could result in a lower serum level and potentially a reduction in efficacy. |
Olanzapine | Olanzapine Olanzapine may increase the hypotensive activities of Macitentan. |
Eprosartan | Eprosartan Eprosartan may increase the hypotensive activities of Macitentan. |
Meloxicam | Meloxicam The therapeutic efficacy of Macitentan can be decreased when used in combination with Meloxicam. |
Pantoprazole | Pantoprazole Pantoprazole may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Telmisartan | Telmisartan Telmisartan may increase the hypotensive activities of Macitentan. |
Temozolomide | Temozolomide Temozolomide may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Zaleplon | Zaleplon Zaleplon may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Linezolid | Linezolid Linezolid may increase the hypotensive activities of Macitentan. |
Trimipramine | Trimipramine Trimipramine may decrease the antihypertensive activities of Macitentan. |
Perindopril | Perindopril Perindopril may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Tenofovir | Tenofovir Tenofovir may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Choline Magnesium Trisalicylate | Choline Magnesium Trisalicylate The therapeutic efficacy of Macitentan can be decreased when used in combination with Choline magnesium trisalicylate. |
Dutasteride | Dutasteride Dutasteride may decrease the antihypertensive activities of Macitentan. |
Epinephrine Injection | Epinephrine Injection Epinephrine may decrease the antihypertensive activities of Macitentan. |
Eplerenone | Eplerenone Eplerenone may increase the excretion rate of Macitentan which could result in a lower serum level and potentially a reduction in efficacy. |
Olmesartan | Olmesartan Olmesartan may increase the hypotensive activities of Macitentan. |
Zonisamide | Zonisamide Zonisamide may increase the excretion rate of Macitentan which could result in a lower serum level and potentially a reduction in efficacy. |
Aripiprazole | Aripiprazole The risk or severity of hypotension can be increased when Aripiprazole is combined with Macitentan. |
Atomoxetine | Atomoxetine Atomoxetine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Dexmethylphenidate | Dexmethylphenidate Dexmethylphenidate may decrease the antihypertensive activities of Macitentan. |
Atazanavir | Atazanavir Atazanavir may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Almotriptan | Almotriptan Almotriptan may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Eletriptan | Eletriptan Eletriptan may decrease the antihypertensive activities of Macitentan. |
Vardenafil | Vardenafil Vardenafil may increase the antihypertensive activities of Macitentan. |
Alfuzosin | Alfuzosin Alfuzosin may increase the hypotensive activities of Macitentan. |
Emtricitabine | Emtricitabine Emtricitabine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Memantine | Memantine Memantine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Tadalafil | Tadalafil Tadalafil may increase the antihypertensive activities of Macitentan. |
Frovatriptan | Frovatriptan Frovatriptan may decrease the antihypertensive activities of Macitentan. |
Apomorphine Injection | Apomorphine Injection Apomorphine may increase the hypotensive activities of Macitentan. |
Protriptyline | Protriptyline Protriptyline may decrease the antihypertensive activities of Macitentan. |
Duloxetine | Duloxetine Duloxetine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Tinidazole | Tinidazole Tinidazole may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Bosentan | Bosentan Bosentan may increase the hypotensive activities of Macitentan. |
Cefditoren | Cefditoren Cefdinir may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Cyanocobalamin Injection | Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Eszopiclone | Eszopiclone Eszopiclone may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Ganciclovir | Ganciclovir Ganciclovir may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Ribavirin | Ribavirin Ribavirin may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Solifenacin | Solifenacin Solifenacin may decrease the antihypertensive activities of Macitentan. |
Valganciclovir | Valganciclovir Valganciclovir may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Adefovir | Adefovir Adefovir may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Dextroamphetamine | Dextroamphetamine Amphetamine may increase the hypotensive activities of Macitentan. |
Isocarboxazid | Isocarboxazid Isocarboxazid may increase the hypotensive activities of Macitentan. |
Ramelteon | Ramelteon Ramelteon may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Fentanyl | Fentanyl Fentanyl may decrease the antihypertensive activities of Macitentan. |
Pregabalin | Pregabalin Pregabalin may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Phenylephrine | Phenylephrine Phenylephrine may decrease the antihypertensive activities of Macitentan. |
Ranolazine | Ranolazine Ranolazine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Rasagiline | Rasagiline Rasagiline may increase the hypotensive activities of Macitentan. |
Sitagliptin | Sitagliptin Sitagliptin may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Varenicline | Varenicline Varenicline may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Albuterol | Albuterol Salbutamol may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Paliperidone | Paliperidone Paliperidone may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Clofarabine Injection | Clofarabine Injection Clofarabine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Lubiprostone | Lubiprostone Lubiprostone may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Rituximab Injection | Rituximab Injection Macitentan may increase the hypotensive activities of Rituximab. |
Aliskiren | Aliskiren Macitentan may increase the hypotensive activities of Aliskiren. |
Pemetrexed Injection | Pemetrexed Injection Macitentan may decrease the excretion rate of Pemetrexed which could result in a higher serum level. |
Lisdexamfetamine | Lisdexamfetamine Lisdexamfetamine may decrease the antihypertensive activities of Macitentan. |
Nabilone | Nabilone Nabilone may increase the hypotensive activities of Macitentan. |
Sorafenib | Sorafenib Sorafenib may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Levocetirizine | Levocetirizine Levocetirizine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Pegaptanib Injection | Pegaptanib Injection Pegaptanib may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Azacitidine Injection | Azacitidine Injection Azacitidine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Lenalidomide | Lenalidomide Lenalidomide may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Budesonide | Budesonide Budesonide may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Desmopressin | Desmopressin Desmopressin may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Doripenem Injection | Doripenem Injection Doripenem may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Arsenic Trioxide Injection | Arsenic Trioxide Injection Arsenic trioxide may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Desvenlafaxine | Desvenlafaxine Desvenlafaxine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Cevimeline | Cevimeline Cevimeline may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Nebivolol | Nebivolol Nebivolol may increase the hypotensive activities of Macitentan. |
Tretinoin | Tretinoin Tretinoin may increase the hypotensive activities of Macitentan. |
Certolizumab Injection | Certolizumab Injection Certolizumab pegol may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Daptomycin Injection | Daptomycin Injection Daptomycin may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Methylnaltrexone Injection | Methylnaltrexone Injection Methylnaltrexone may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Midazolam | Midazolam Midazolam may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Dexrazoxane Injection | Dexrazoxane Injection Dexrazoxane may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Milnacipran | Milnacipran Milnacipran may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Plerixafor Injection | Plerixafor Injection Plerixafor may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Fesoterodine | Fesoterodine Fesoterodine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Betaxolol | Betaxolol Betaxolol may increase the hypotensive activities of Macitentan. |
Iloperidone | Iloperidone Iloperidone may decrease the antihypertensive activities of Macitentan. |
Prasugrel | Prasugrel Prasugrel may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Tolvaptan (low blood sodium) | Tolvaptan (low blood sodium) Tolvaptan may increase the excretion rate of Macitentan which could result in a lower serum level and potentially a reduction in efficacy. |
Dronedarone | Dronedarone Dronedarone may decrease the antihypertensive activities of Macitentan. |
Pralatrexate Injection | Pralatrexate Injection Pralatrexate may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Palonosetron Injection | Palonosetron Injection Palonosetron may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Saxagliptin | Saxagliptin Saxagliptin may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Telavancin Injection | Telavancin Injection Telavancin may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Topotecan | Topotecan Topotecan may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Asenapine | Asenapine Asenapine may decrease the antihypertensive activities of Macitentan. |
Dalfampridine | Dalfampridine Dalfampridine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Ceftaroline Injection | Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Lurasidone | Lurasidone Lurasidone may decrease the antihypertensive activities of Macitentan. |
Acetaminophen Injection | Acetaminophen Injection Acetaminophen may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Vilazodone | Vilazodone Vilazodone may decrease the antihypertensive activities of Macitentan. |
Ipilimumab Injection | Ipilimumab Injection Ipilimumab may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Denileukin Diftitox Injection | Denileukin Diftitox Injection Aldesleukin may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Terbutaline Injection | Terbutaline Injection Terbutaline may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Azilsartan | Azilsartan Azilsartan medoxomil may increase the hypotensive activities of Macitentan. |
Roflumilast | Roflumilast Roflumilast may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Rivaroxaban | Rivaroxaban Rivaroxaban may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Ruxolitinib | Ruxolitinib Ruxolitinib may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Clobazam | Clobazam Clobazam may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Deferiprone | Deferiprone Deferiprone may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Cabergoline | Cabergoline Cabergoline may decrease the antihypertensive activities of Macitentan. |
Naloxone Injection | Naloxone Injection Naloxone may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Ambrisentan | Ambrisentan Ambrisentan may increase the hypotensive activities of Macitentan. |
Fondaparinux Injection | Fondaparinux Injection Fondaparinux may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Iloprost | Iloprost Iloprost may increase the hypotensive activities of Macitentan. |
Enzalutamide | Enzalutamide Enzalutamide may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Mirabegron | Mirabegron Mirabegron may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Teduglutide Injection | Teduglutide Injection Teduglutide may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Alogliptin | Alogliptin Alogliptin may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Pomalidomide | Pomalidomide Pomalidomide may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Canagliflozin | Canagliflozin Canagliflozin may increase the excretion rate of Macitentan which could result in a lower serum level and potentially a reduction in efficacy. |
Methazolamide | Methazolamide Methazolamide may increase the excretion rate of Macitentan which could result in a lower serum level and potentially a reduction in efficacy. |
Trametinib | Trametinib Trametinib may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Levomilnacipran | Levomilnacipran Levomilnacipran may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Ertapenem Injection | Ertapenem Injection Ertapenem may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Vortioxetine | Vortioxetine Macitentan may decrease the excretion rate of Vortioxetine which could result in a higher serum level. |
Avanafil | Avanafil Avanafil may increase the antihypertensive activities of Macitentan. |
Ketorolac Injection | Ketorolac Injection The therapeutic efficacy of Macitentan can be decreased when used in combination with Ketorolac. |
Obinutuzumab Injection | Obinutuzumab Injection Macitentan may increase the hypotensive activities of Obinutuzumab. |
Sofosbuvir | Sofosbuvir Macitentan may decrease the excretion rate of Sofosbuvir which could result in a higher serum level. |
Dapagliflozin | Dapagliflozin Dapagliflozin may increase the excretion rate of Macitentan which could result in a lower serum level and potentially a reduction in efficacy. |
Apremilast | Apremilast Apremilast may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Droxidopa | Droxidopa Droxidopa may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Testosterone Injection | Testosterone Injection Testosterone may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Empagliflozin | Empagliflozin Empagliflozin may increase the hypotensive activities of Macitentan. |
Edoxaban | Edoxaban Macitentan may decrease the excretion rate of Edoxaban which could result in a higher serum level. |
Methamphetamine | Methamphetamine Metamfetamine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Tasimelteon | Tasimelteon Macitentan may decrease the excretion rate of Tasimelteon which could result in a higher serum level. |
Riociguat | Riociguat Riociguat may increase the hypotensive activities of Macitentan. |
Risperidone Injection | Risperidone Injection Risperidone may decrease the antihypertensive activities of Macitentan. |
Dinutuximab Injection | Dinutuximab Injection Dinutuximab may increase the hypotensive activities of Macitentan. |
Haloperidol Injection | Haloperidol Injection The serum concentration of Macitentan can be increased when it is combined with Haloperidol. |
Amiloride | Amiloride Amiloride may increase the excretion rate of Macitentan which could result in a lower serum level and potentially a reduction in efficacy. |
Flibanserin | Flibanserin Flibanserin may decrease the antihypertensive activities of Macitentan. |
Brexpiprazole | Brexpiprazole Brexpiprazole may decrease the antihypertensive activities of Macitentan. |
Ziprasidone Injection | Ziprasidone Injection Ziprasidone may increase the antihypertensive activities of Macitentan. |
Cariprazine | Cariprazine Cariprazine may decrease the antihypertensive activities of Macitentan. |
Penicillin G Procaine Injection | Penicillin G Procaine Injection Macitentan may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level. |
Ixazomib | Ixazomib Macitentan may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
Lesinurad | Lesinurad Macitentan may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
Amphotericin B Liposomal Injection | Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Brivaracetam Injection | Brivaracetam Injection Brivaracetam may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Midodrine | Midodrine Midodrine may decrease the antihypertensive activities of Macitentan. |
Selexipag | Selexipag Macitentan may increase the hypotensive activities of Selexipag. |
Furosemide Injection | Furosemide Injection Furosemide may increase the excretion rate of Macitentan which could result in a lower serum level and potentially a reduction in efficacy. |
Lixisenatide Injection | Lixisenatide Injection Macitentan may decrease the excretion rate of Lixisenatide which could result in a higher serum level. |
Doxepin (Insomnia) | Doxepin (Insomnia) Doxepin may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Deutetrabenazine | Deutetrabenazine Macitentan may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level. |
Valbenazine | Valbenazine Macitentan may decrease the excretion rate of Valbenazine which could result in a higher serum level. |
Safinamide | Safinamide Safinamide may increase the hypotensive activities of Macitentan. |
Naldemedine | Naldemedine Macitentan may decrease the excretion rate of Naldemedine which could result in a higher serum level. |
Benznidazole | Benznidazole Macitentan may decrease the excretion rate of Benznidazole which could result in a higher serum level. |
Delafloxacin | Delafloxacin Macitentan may decrease the excretion rate of Delafloxacin which could result in a higher serum level. |
Ertugliflozin | Ertugliflozin Ertugliflozin may increase the excretion rate of Macitentan which could result in a lower serum level and potentially a reduction in efficacy. |
Apalutamide | Apalutamide Macitentan may decrease the excretion rate of Apalutamide which could result in a higher serum level. |
Fostamatinib | Fostamatinib Fostamatinib may increase the antihypertensive activities of Macitentan. |
Baricitinib | Baricitinib Macitentan may decrease the excretion rate of Baricitinib which could result in a higher serum level. |
Lofexidine | Lofexidine Lofexidine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Plazomicin Injection | Plazomicin Injection Macitentan may decrease the excretion rate of Plazomicin which could result in a higher serum level. |
Cannabidiol | Cannabidiol Cannabidiol may decrease the antihypertensive activities of Macitentan. |
Stiripentol | Stiripentol Macitentan may decrease the excretion rate of Stiripentol which could result in a higher serum level. |
Paclitaxel (with albumin) Injection | Paclitaxel (with albumin) Injection Paclitaxel may increase the hypotensive activities of Macitentan. |
Prucalopride | Prucalopride Prucalopride may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Siponimod | Siponimod Siponimod may decrease the antihypertensive activities of Macitentan. |
Acyclovir Ophthalmic | Acyclovir Ophthalmic Acyclovir may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Solriamfetol | Solriamfetol Macitentan may decrease the excretion rate of Solriamfetol which could result in a higher serum level. |
Pitolisant | Pitolisant The serum concentration of Macitentan can be decreased when it is combined with Pitolisant. |
Cenobamate | Cenobamate The serum concentration of Macitentan can be decreased when it is combined with Cenobamate. |
Tucatinib | Tucatinib The metabolism of Tucatinib can be decreased when combined with Macitentan. |
Selpercatinib | Selpercatinib Selpercatinib may decrease the antihypertensive activities of Macitentan. |
Satralizumab-mwge Injection | Satralizumab-mwge Injection The serum concentration of Macitentan can be decreased when it is combined with Satralizumab. |
Naxitamab-gqgk Injection | Naxitamab-gqgk Injection Naxitamab may decrease the antihypertensive activities of Macitentan. |
Progestin-Only (drospirenone) Oral Contraceptives | Progestin-Only (drospirenone) Oral Contraceptives Drospirenone may increase the excretion rate of Macitentan which could result in a lower serum level and potentially a reduction in efficacy. |
Viloxazine | Viloxazine Macitentan may decrease the excretion rate of Viloxazine which could result in a higher serum level. |
Tobramycin Injection | Tobramycin Injection Tobramycin may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Fenoprofen | Fenoprofen The therapeutic efficacy of Macitentan can be decreased when used in combination with Fenoprofen. |
Indomethacin | Indomethacin The therapeutic efficacy of Macitentan can be decreased when used in combination with Indomethacin. |
Mefenamic Acid | Mefenamic Acid The therapeutic efficacy of Macitentan can be decreased when used in combination with Mefenamic acid. |
Naproxen | Naproxen The therapeutic efficacy of Macitentan can be decreased when used in combination with Naproxen. |
Tolmetin | Tolmetin The therapeutic efficacy of Macitentan can be decreased when used in combination with Tolmetin. |
Sulindac | Sulindac The therapeutic efficacy of Macitentan can be decreased when used in combination with Sulindac. |
Trazodone | Trazodone Trazodone may decrease the antihypertensive activities of Macitentan. |
Isotretinoin | Isotretinoin Isotretinoin may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Sucralfate | Sucralfate Sucralfate may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Floxuridine | Floxuridine Floxuridine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Metaxalone | Metaxalone Metaxalone may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Methotrexate Injection | Methotrexate Injection Methotrexate may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Diethylpropion | Diethylpropion Diethylpropion may decrease the antihypertensive activities of Macitentan. |
Chlorpromazine | Chlorpromazine Chlorpromazine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Diazepam | Diazepam Diazepam may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Oxazepam | Oxazepam Oxazepam may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Flurazepam | Flurazepam Flurazepam may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Clorazepate | Clorazepate Clorazepic acid may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Lorazepam | Lorazepam Lorazepam may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Phenoxybenzamine | Phenoxybenzamine Phenoxybenzamine may decrease the antihypertensive activities of Macitentan. |
Carmustine | Carmustine Carmustine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Amantadine | Amantadine Amantadine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Codeine | Codeine Codeine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Bromocriptine | Bromocriptine Bromocriptine may decrease the antihypertensive activities of Macitentan. |
Metaproterenol | Metaproterenol Orciprenaline may decrease the antihypertensive activities of Macitentan. |
Tranylcypromine | Tranylcypromine Tranylcypromine may increase the hypotensive activities of Macitentan. |
Phenelzine | Phenelzine Phenelzine may increase the hypotensive activities of Macitentan. |
Procarbazine | Procarbazine Procarbazine may increase the hypotensive activities of Macitentan. |
Ergoloid Mesylates | Ergoloid Mesylates Ergoloid mesylate may decrease the antihypertensive activities of Macitentan. |
Tetracycline | Tetracycline Tetracycline may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Thioridazine | Thioridazine Thioridazine may decrease the antihypertensive activities of Macitentan. |
Trifluoperazine | Trifluoperazine Trifluoperazine may decrease the antihypertensive activities of Macitentan. |
Bleomycin | Bleomycin Bleomycin may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Sulfadiazine | Sulfadiazine Sulfadiazine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Methadone | Methadone Methadone may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Benztropine | Benztropine Benzatropine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Maprotiline | Maprotiline Maprotiline may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Ibuprofen | Ibuprofen The therapeutic efficacy of Macitentan can be decreased when used in combination with Ibuprofen. |
Azathioprine | Azathioprine Azathioprine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Phentermine | Phentermine Phentermine may decrease the antihypertensive activities of Macitentan. |
Methylphenidate | Methylphenidate Methylphenidate may decrease the antihypertensive activities of Macitentan. |
Amoxapine | Amoxapine Amoxapine may decrease the antihypertensive activities of Macitentan. |
Sulfasalazine | Sulfasalazine The therapeutic efficacy of Macitentan can be decreased when used in combination with Sulfasalazine. |
Phenazopyridine | Phenazopyridine Phenazopyridine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Carbamazepine | Carbamazepine Carbamazepine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Methyldopa | Methyldopa Methyldopa may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Clonidine | Clonidine The risk or severity of hypotension can be increased when Clonidine is combined with Macitentan. |
Prazosin | Prazosin The risk or severity of hypotension can be increased when Prazosin is combined with Macitentan. |
Hydralazine | Hydralazine Hydralazine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Cimetidine | Cimetidine Cimetidine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Gentamicin Injection | Gentamicin Injection Gentamicin may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Warfarin | Warfarin Warfarin may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Clonazepam | Clonazepam Clonazepam may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Promethazine | Promethazine Promethazine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Meclofenamate | Meclofenamate The therapeutic efficacy of Macitentan can be decreased when used in combination with Meclofenamic acid. |
Nitrofurantoin | Nitrofurantoin Nitrofurantoin may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Digoxin | Digoxin Macitentan may decrease the excretion rate of Digoxin which could result in a higher serum level. |
Chloroquine | Chloroquine Chloroquine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Quinine | Quinine Quinine may increase the hypotensive activities of Macitentan. |
Triamterene | Triamterene Triamterene may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Chlorothiazide | Chlorothiazide The therapeutic efficacy of Macitentan can be increased when used in combination with Chlorothiazide. |
Chlorthalidone | Chlorthalidone Chlorthalidone may increase the excretion rate of Macitentan which could result in a lower serum level and potentially a reduction in efficacy. |
Metolazone | Metolazone Metolazone may increase the excretion rate of Macitentan which could result in a lower serum level and potentially a reduction in efficacy. |
Isosorbide | Isosorbide Isosorbide may increase the excretion rate of Macitentan which could result in a lower serum level and potentially a reduction in efficacy. |
Secobarbital | Secobarbital Secobarbital may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Desipramine | Desipramine Desipramine may decrease the antihypertensive activities of Macitentan. |
Amitriptyline | Amitriptyline Amitriptyline may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Imipramine | Imipramine Imipramine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Probenecid | Probenecid Probenecid may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Quinidine | Quinidine Quinidine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Procainamide | Procainamide Macitentan may decrease the excretion rate of Procainamide which could result in a higher serum level. |
Isoniazid | Isoniazid Isoniazid may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Pyrazinamide | Pyrazinamide Pyrazinamide may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Disopyramide | Disopyramide Disopyramide may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Butabarbital | Butabarbital Butabarbital may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Liothyronine | Liothyronine Liothyronine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Methimazole | Methimazole Methimazole may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Chlorpropamide | Chlorpropamide Chlorpropamide may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Tolbutamide | Tolbutamide Tolbutamide may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Tolazamide | Tolazamide Tolazamide may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Baclofen | Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Macitentan. |
Ethambutol | Ethambutol Ethambutol may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Methyclothiazide | Methyclothiazide The therapeutic efficacy of Macitentan can be increased when used in combination with Methyclothiazide. |
Hydrochlorothiazide | Hydrochlorothiazide The therapeutic efficacy of Macitentan can be increased when used in combination with Hydrochlorothiazide. |
Chlorzoxazone | Chlorzoxazone Chlorzoxazone may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Pyridoxine | Pyridoxine Pyridoxine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Folic Acid | Folic Acid Folic acid may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Propranolol (Cardiovascular) | Propranolol (Cardiovascular) Propranolol may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Minoxidil | Minoxidil Minoxidil may increase the hypotensive activities of Macitentan. |
Pseudoephedrine | Pseudoephedrine Pseudoephedrine may decrease the antihypertensive activities of Macitentan. |
Nortriptyline | Nortriptyline Nortriptyline may decrease the antihypertensive activities of Macitentan. |
Spironolactone | Spironolactone Spironolactone may increase the excretion rate of Macitentan which could result in a lower serum level and potentially a reduction in efficacy. |
Amphotericin B Injection | Amphotericin B Injection Amphotericin B may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Phytonadione | Phytonadione Phylloquinone may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Amikacin Injection | Amikacin Injection Amikacin may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Nadolol | Nadolol Nadolol may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Allopurinol | Allopurinol Allopurinol may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Flavoxate | Flavoxate Flavoxate may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Papaverine | Papaverine Papaverine may increase the hypotensive activities of Macitentan. |
Colchicine | Colchicine Colchicine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Cefaclor | Cefaclor Cefaclor may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Cefadroxil | Cefadroxil Cefadroxil may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Cefazolin Injection | Cefazolin Injection Cefazolin may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Cephalexin | Cephalexin Cephalexin may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Cefoxitin Injection | Cefoxitin Injection Cefoxitin may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Dacarbazine | Dacarbazine Dacarbazine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Acetazolamide | Acetazolamide Acetazolamide may increase the excretion rate of Macitentan which could result in a lower serum level and potentially a reduction in efficacy. |
Cefotaxime Injection | Cefotaxime Injection Cefotaxime may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Calcitonin Salmon Injection | Calcitonin Salmon Injection Salmon calcitonin may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Pyrantel | Pyrantel Macitentan may decrease the excretion rate of Pyrantel which could result in a higher serum level. |
Captopril | Captopril Captopril may increase the hypotensive activities of Macitentan. |
Dipyridamole | Dipyridamole Dipyridamole may increase the antihypertensive activities of Macitentan. |
Isoxsuprine | Isoxsuprine Isoxsuprine may decrease the antihypertensive activities of Macitentan. |
Ethacrynic Acid | Ethacrynic Acid Etacrynic acid may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Colistimethate Injection | Colistimethate Injection Colistimethate may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Metoprolol | Metoprolol Metoprolol may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Aspirin | Aspirin Acetylsalicylic acid may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Salsalate | Salsalate The therapeutic efficacy of Macitentan can be decreased when used in combination with Salsalate. |
Alprazolam | Alprazolam Alprazolam may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Temazepam | Temazepam Temazepam may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Triazolam | Triazolam Triazolam may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Dicyclomine | Dicyclomine Dicyclomine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Propantheline | Propantheline Propantheline may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Trimethoprim | Trimethoprim Trimethoprim may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Diltiazem | Diltiazem Diltiazem may increase the hypotensive activities of Macitentan. |
Nifedipine | Nifedipine Nifedipine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Timolol | Timolol Timolol may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Verapamil | Verapamil Verapamil may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Atenolol | Atenolol Atenolol may increase the hypotensive activities of Macitentan. |
Pindolol | Pindolol Pindolol may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Cisplatin Injection | Cisplatin Injection Macitentan may decrease the excretion rate of Cisplatin which could result in a higher serum level. |
Diflunisal | Diflunisal The therapeutic efficacy of Macitentan can be decreased when used in combination with Diflunisal. |
Piroxicam | Piroxicam The therapeutic efficacy of Macitentan can be decreased when used in combination with Piroxicam. |
Bumetanide | Bumetanide Bumetanide may increase the excretion rate of Macitentan which could result in a lower serum level and potentially a reduction in efficacy. |
Glipizide | Glipizide Glipizide may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Indapamide | Indapamide The therapeutic efficacy of Macitentan can be increased when used in combination with Indapamide. |
Amoxicillin | Amoxicillin Amoxicillin may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Oxacillin Injection | Oxacillin Injection Oxacillin may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Pentoxifylline | Pentoxifylline Pentoxifylline may increase the hypotensive activities of Macitentan. |
Pentamidine Injection | Pentamidine Injection Pentamidine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Ceftriaxone Injection | Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Labetalol | Labetalol Labetalol may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Auranofin | Auranofin Auranofin may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Leuprolide Injection | Leuprolide Injection Leuprolide may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Gemfibrozil | Gemfibrozil Gemfibrozil may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Guanabenz | Guanabenz Guanabenz may increase the hypotensive activities of Macitentan. |
Dipivefrin Ophthalmic | Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Ceftazidime Injection | Ceftazidime Injection Ceftazidime may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Ketoprofen | Ketoprofen The therapeutic efficacy of Macitentan can be decreased when used in combination with Ketoprofen. |
Cefotetan Injection | Cefotetan Injection Cefotetan may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Enalapril | Enalapril Enalapril may increase the hypotensive activities of Macitentan. |
Flurbiprofen | Flurbiprofen The therapeutic efficacy of Macitentan can be decreased when used in combination with Flurbiprofen. |
Amiodarone | Amiodarone Amiodarone may increase the hypotensive activities of Macitentan. |
Aztreonam Injection | Aztreonam Injection Aztreonam may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Buspirone | Buspirone Buspirone may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Ciprofloxacin | Ciprofloxacin Ciprofloxacin may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Mesalamine | Mesalamine The therapeutic efficacy of Macitentan can be decreased when used in combination with Mesalazine. |
Diclofenac | Diclofenac The therapeutic efficacy of Macitentan can be decreased when used in combination with Diclofenac. |
Nimodipine | Nimodipine Nimodipine may increase the hypotensive activities of Macitentan. |
Clozapine | Clozapine Clozapine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Estazolam | Estazolam Estazolam may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Didanosine | Didanosine Didanosine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Pentostatin Injection | Pentostatin Injection Pentostatin may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Benazepril | Benazepril Benazepril may increase the hypotensive activities of Macitentan. |
Etodolac | Etodolac The therapeutic efficacy of Macitentan can be decreased when used in combination with Etodolac. |
Felodipine | Felodipine Felodipine may increase the hypotensive activities of Macitentan. |
Fosinopril | Fosinopril Fosinopril may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Nabumetone | Nabumetone The therapeutic efficacy of Macitentan can be decreased when used in combination with Nabumetone. |
Quinapril | Quinapril Quinapril may increase the hypotensive activities of Macitentan. |
Ramipril | Ramipril Ramipril may increase the hypotensive activities of Macitentan. |
Amlodipine | Amlodipine Amlodipine may increase the hypotensive activities of Macitentan. |
Lisinopril | Lisinopril Lisinopril may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Oxaprozin | Oxaprozin The therapeutic efficacy of Macitentan can be decreased when used in combination with Oxaprozin. |
Sotalol | Sotalol Sotalol may increase the hypotensive activities of Macitentan. |
Bisoprolol | Bisoprolol Bisoprolol may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Doxazosin | Doxazosin Doxazosin may increase the hypotensive activities of Macitentan. |
Terazosin | Terazosin Terazosin may increase the hypotensive activities of Macitentan. |
Isradipine | Isradipine Isradipine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Venlafaxine | Venlafaxine Venlafaxine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Fluvoxamine | Fluvoxamine Fluvoxamine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Nefazodone | Nefazodone Nefazodone may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Lamotrigine | Lamotrigine Lamotrigine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Losartan | Losartan Losartan may increase the hypotensive activities of Macitentan. |
Valacyclovir | Valacyclovir Valaciclovir may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Tramadol | Tramadol Tramadol may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Carboplatin Injection | Carboplatin Injection Carboplatin may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Moexipril | Moexipril Moexipril may increase the hypotensive activities of Macitentan. |
Ifosfamide Injection | Ifosfamide Injection Ifosfamide may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Nicardipine | Nicardipine Nicardipine may increase the hypotensive activities of Macitentan. |
Bupropion | Bupropion Bupropion may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Ticlopidine | Ticlopidine Ticlopidine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Metformin | Metformin Metformin may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Nisoldipine | Nisoldipine Nisoldipine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Lamivudine | Lamivudine Lamivudine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Amifostine Injection | Amifostine Injection Macitentan may increase the hypotensive activities of Amifostine. |
Acarbose | Acarbose Acarbose may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Gemcitabine Injection | Gemcitabine Injection Gemcitabine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Ritonavir | Ritonavir The serum concentration of Macitentan can be increased when it is combined with Ritonavir. |
Cidofovir Injection | Cidofovir Injection Cidofovir may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Meropenem Injection | Meropenem Injection Meropenem may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Clomipramine | Clomipramine Clomipramine may decrease the antihypertensive activities of Macitentan. |
Fosfomycin | Fosfomycin Fosfomycin may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Mirtazapine | Mirtazapine Mirtazapine may decrease the antihypertensive activities of Macitentan. |
Trandolapril | Trandolapril Trandolapril may increase the hypotensive activities of Macitentan. |
Topiramate | Topiramate Topiramate may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Valsartan | Valsartan Valsartan may increase the hypotensive activities of Macitentan. |
Pramipexole | Pramipexole Pramipexole may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Carvedilol | Carvedilol Carvedilol may increase the hypotensive activities of Macitentan. |
Nilutamide | Nilutamide Nilutamide may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Flutamide | Flutamide Flutamide may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Selegiline | Selegiline Selegiline may increase the hypotensive activities of Macitentan. |
Propafenone | Propafenone Propafenone may decrease the antihypertensive activities of Macitentan. |
Irbesartan | Irbesartan Irbesartan may increase the hypotensive activities of Macitentan. |
Tamsulosin | Tamsulosin Tamsulosin may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Ropinirole | Ropinirole Ropinirole may increase the hypotensive activities of Macitentan. |
Finasteride | Finasteride Finasteride may decrease the antihypertensive activities of Macitentan. |
Quetiapine | Quetiapine Quetiapine may increase the hypotensive activities of Macitentan. |
Cefepime Injection | Cefepime Injection Cefepime may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Cefprozil | Cefprozil Cefprozil may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Cefpodoxime | Cefpodoxime Cefpodoxime may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Cetirizine | Cetirizine Cetirizine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Tolcapone | Tolcapone Tolcapone may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Capecitabine | Capecitabine Capecitabine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Abacavir | Abacavir Abacavir may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Sildenafil | Sildenafil Sildenafil may increase the antihypertensive activities of Macitentan. |
Celecoxib | Celecoxib The therapeutic efficacy of Macitentan can be decreased when used in combination with Celecoxib. |
Rosiglitazone | Rosiglitazone Rosiglitazone may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Tolterodine | Tolterodine Tolterodine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Thalidomide | Thalidomide Thalidomide may increase the hypotensive activities of Macitentan. |
Oseltamivir | Oseltamivir Oseltamivir may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Balsalazide | Balsalazide The therapeutic efficacy of Macitentan can be decreased when used in combination with Balsalazide. |
Nateglinide | Nateglinide Nateglinide may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Rabeprazole | Rabeprazole Rabeprazole may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists