Fentanyl

Generic name: Pronounced as (fen' ta nil)
Brand names
  • Abstral®
  • Actiq®
  • Fentora®
  • Onsolis®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 01/15/2021

Fentanyl may be habit forming, especially with prolonged use. Use fentanyl exactly as directed. Do not use a larger dose of fentanyl, use the medication more often, or use it for a longer period of time than prescribed by your doctor. While using fentanyl, discuss with your health care provider your pain treatment goals, length of treatment, and other ways to manage your pain. Tell your doctor if you or anyone in your family drinks or has ever drunk large amounts of alcohol, uses or has ever used street drugs, or has overused prescription medications, or has had an overdose, or if you have or have ever had depression or another mental illness. There is a greater risk that you will overuse fentanyl if you have or have ever had any of these conditions. Talk to your health care provider immediately and ask for guidance if you think that you have an opioid addiction or call the U.S. Substance Abuse and Mental Health Services Administration (SAMHSA) National Helpline at 1-800-662-HELP.

Fentanyl should only be prescribed by doctors who are experienced in treating pain in cancer patients. It should be used only to treat breakthrough cancer pain (sudden episodes of pain that occur despite around-the-clock treatment with pain medication) in cancer patients at least 18 years of age (or at least 16 years of age if using Actiq brand lozenges) who are taking regularly scheduled doses of another narcotic (opiate) pain medication, and who are tolerant (used to the effects of the medication) to narcotic pain medications. This medication should not be used to treat pain other than chronic cancer pain, especially short-term pain such as migraines or other headaches, pain from an injury, or pain after a medical or dental procedure. Fentanyl may cause serious breathing problems or death if it is used by people who are not being treated with other narcotic medications or who are not tolerant to narcotic medications.

Fentanyl may cause serious harm or death if used accidentally by a child or by an adult who has not been prescribed the medication. Even partially used fentanyl may contain enough medication to cause serious harm or death to children or other adults. Keep fentanyl out of reach of children, and if you are using the lozenges, ask your doctor how to obtain a kit from the manufacturer containing child safety locks and other supplies to prevent children from getting the medication. Dispose of partially used lozenges according to the manufacturer's directions immediately after you remove them from your mouth. If fentanyl is used by a child or an adult who has not been prescribed the medication, try to remove the medication from the person's mouth and get emergency medical help.

Fentanyl should be used along with your other pain medication(s). Do not stop taking your other pain medication(s) when you begin your treatment with fentanyl. If you stop taking your other pain medication(s) you will need to stop using fentanyl.

If you still have pain after using one lozenge or tablet, your doctor may tell you to use a second lozenge or tablet. You may use the second lozenge (Actiq) 15 minutes after you finish the first lozenge, or use the second tablet (Abstral, Fentora) 30 minutes after you started using the first tablet. Do not use a second lozenge or tablet to treat the same episode of pain unless your doctor tells you that you should. If you are using fentanyl film (Onsolis), you should not use a second dose to treat the same episode of pain. After you treat an episode of pain using 1 or 2 doses of fentanyl as directed, you must wait at least 2 hours after using fentanyl (Abstral or Onsolis) or 4 hours after using fentanyl (Actiq or Fentora) before treating another episode of breakthrough cancer pain.

Taking certain medications with fentanyl may increase the risk that you will develop serious or life-threatening breathing problems, sedation, or coma. Tell your doctor if you are taking any of the following medications: amiodarone (Nexterone, Pacerone); certain antibiotics such as clarithromycin (Biaxin, in PrevPac), erythromycin (Erythocin), telithromycin (Ketek), and troleandomycin (TAO) (not available in the US); certain antifungals such as fluconazole (Diflucan), itraconazole (Onmel, Sporanox), and ketoconazole (Nizoral); aprepitant (Emend); benzodiazepines such as alprazolam (Xanax), chlordiazepoxide (Librium), clonazepam (Klonopin), diazepam (Diastat, Valium), estazolam, flurazepam, lorazepam (Ativan), oxazepam, temazepam (Restoril), and triazolam (Halcion); cimetidine (Tagamet); diltiazem (Cardizem, Taztia, Tiazac, others); certain medications for human immunodeficiency virus (HIV) such as amprenavir (Agenerase), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), and saquinavir (Invirase); medications for mental illness and nausea; muscle relaxants; nefazodone; sedatives; sleeping pills; tranquilizers; or verapamil (Calan, Covera, Verelan). Your doctor may need to change the dosages of your medications and will monitor you carefully. If you use fentanyl with any of these medications and you develop any of the following symptoms, call your doctor immediately or seek emergency medical care: unusual dizziness, lightheadedness, extreme sleepiness, slowed or difficult breathing, or unresponsiveness. Be sure that your caregiver or family members know which symptoms may be serious so they can call the doctor or emergency medical care if you are unable to seek treatment on your own.

Fentanyl comes as four different transmucosal products and several other types of products. The medication in each product is absorbed differently by the body, so one product cannot be substituted for any other fentanyl product. If you are switching from one product to another, your doctor will prescribe a dose that is best for you.

A program has been set up for each fentanyl product to decrease the risk of using the medication. Your doctor will need to enroll in the program in order to prescribe fentanyl and you will need to have your prescription filled at a pharmacy that is enrolled in the program. As part of the program, your doctor will talk with you about the risks and benefits of using fentanyl and about how to safely use, store, and dispose of the medication. After you talk with your doctor, you will sign a form acknowledging that you understand the risks of using fentanyl and that you will follow your doctor's instructions to use the medication safely. Your doctor will give you more information about the program and how to get your medication and will answer any questions you have about the program and your treatment with fentanyl.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with fentanyl and each time you get more medication. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/drugs/drugsafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide.

Talk to your doctor about the risks of using this medication.

Fentanyl is used to treat breakthrough pain (sudden episodes of pain that occur despite round the clock treatment with pain medication) in cancer patients at least 18 years of age (or at least 16 years of age if using Actiq brand lozenges) who are taking regularly scheduled doses of another narcotic (opiate) pain medication, and who are tolerant (used to the effects of the medication) to narcotic pain medications. Fentanyl is in a class of medications called narcotic (opiate) analgesics. It works by changing the way the brain and nervous system respond to pain.

Fentanyl comes as a lozenge on a handle (Actiq), a sublingual (underneath the tongue) tablet (Abstral), a film (Onsolis), and a buccal (between the gum and cheek) tablet (Fentora) to dissolve in the mouth. Fentanyl is used as needed to treat breakthrough pain but not more often than four times a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.

Your doctor will probably start you on a low dose of fentanyl and gradually increase your dose until you find the dose that will relieve your breakthrough pain. If you still have pain 30 minutes after using fentanyl films (Onsolis), your doctor may tell you to use another pain medication to relieve that pain, and may increase your dose of fentanyl films (Onsolis) to treat your next episode of pain . Talk to your doctor about how well the medication is working and whether you are experiencing any side effects so that your doctor can decide whether your dose should be adjusted.

Do not use fentanyl more than four times a day. Call your doctor if you experience more than four episodes of breakthrough pain per day. Your doctor may need to adjust the dose of your other pain medication(s) to better control your pain.

Swallow the buccal tablet whole; do not split, chew, or crush. Also do not chew or bite the lozenge on a handle; only suck on this medication as directed.

Do not stop using fentanyl without talking to your doctor. Your doctor may decrease your dose gradually. If you suddenly stop using fentanyl, you may experience unpleasant withdrawal symptoms.

To use fentanyl lozenges (Actiq), follow these steps:

  1. Check the blister package and the handle of the lozenge to make sure the lozenge contains the dose of medication you have been prescribed.

  2. Use scissors to cut open the blister package and remove the lozenge. Do not open the blister package until you are ready to use the medication.

  3. Place the lozenge in your mouth, between your cheek and gum. Actively suck on the lozenge, but do not chew, crush, or bite it. Move the lozenge around in your mouth, from one side to the other, using the handle. Twirl the handle often.

  4. Do not eat or drink anything while the lozenge is in your mouth.

  5. Finish the lozenge in about 15 minutes.

  6. If you begin to feel dizzy, very sleepy, or nauseated before you have finished the lozenge, remove it from your mouth. Dispose of it immediately as described below or put it in the temporary storage bottle for later disposal.

  7. If you finish the entire lozenge, throw the handle away in a garbage can that is out of the reach of children. If you did not finish the entire lozenge, hold the handle under hot running water to dissolve all the medication, and then throw the handle away in a garbage can that is out of the reach of children and pets.

To use fentanyl buccal tablets (Fentora), follow these steps:

  1. Separate one blister unit from the blister card by tearing along the perforations. Peel back the foil to open the blister unit. Do not try to push the tablet through the foil. Do not open the blister unit until you are ready to use the tablet.

  2. Place the tablet in your mouth above one of your upper back teeth between your cheek and your gum.

  3. Leave the tablet in place until it dissolves completely. You may notice a gentle bubbling feeling between your cheek and gum as the tablet dissolves. It may take 14 to 25 minutes for the tablet to dissolve. Do not split, chew, bite, or suck the tablet.

  4. If any of the tablet is left in your mouth after 30 minutes, swallow it with a drink of water.

  5. If you begin to feel dizzy, very sleepy, or nauseated before the tablet dissolves, rinse your mouth with water and spit the remaining pieces of tablet into the sink or toilet. Flush the toilet or rinse the sink to wash away the tablet pieces.

To use fentanyl sublingual tablets (Abstral), follow these steps:

  1. Take a sip of water to moisten your mouth if it is dry. Spit out or swallow the water. Make sure your hands are dry before handling the tablet.

  2. Separate one blister unit from the blister card by tearing along the perforations. Peel back the foil to open the blister unit. Do not try to push the tablet through the foil. Do not open the blister unit until you are ready to use the tablet.

  3. Place the tablet under your tongue as far back as you can. If more than 1 tablet is needed for your dose, spread them around on the floor of your mouth under your tongue.

  4. Leave the tablet in place until it dissolves completely. Do not suck, chew, or swallow the tablet.

  5. Do not eat or drink anything until the tablet is completely dissolved and you no longer feel it in your mouth.

To use fentanyl films (Onsolis), follow these steps:

  1. Use scissors to cut along the arrows of the foil package to open it. Separate the layers of the foil package and remove the film. Do not open the foil package until you are ready to use the medication. Do not cut or tear the film.

  2. Use your tongue to wet the inside of your cheek, or if needed, rinse your mouth with water to wet the area where you will place the film.

  3. Hold the film on a clean, dry finger, with the pink side facing up. Place the film in your mouth, with the pink side against the inside of your moistened cheek. With your finger, press the film against your cheek for 5 seconds. Then remove your finger and the film will stick to the inside of your cheek. If more than one film is needed for your dose, do not put the films on top of each other. You may place the films on either side of your mouth.

  4. Leave the film in place until it dissolves completely. The film will release a minty flavor as it dissolves. It may take 15 to 30 minutes for the film to dissolve. Do not chew or swallow the film. Do not touch or move the film while it dissolves.

  5. You may drink liquids after 5 minutes, but do not eat anything until the film dissolves completely.

This medication should not be prescribed for other uses; ask your doctor or pharmacist for more information.

Before using fentanyl,

  • tell your doctor and pharmacist if you are allergic to fentanyl patches, injection, nasal spray, tablets, lozenges, or films; any other medications; or any of the ingredients in fentanyl tablets, lozenges, or films. Ask your pharmacist or check the Medication Guide for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following medications: antihistamines; barbiturates such as phenobarbital; buprenorphine (Buprenex, Subutex, in Suboxone); butorphanol (Stadol); carbamazepine (Carbatrol, Epitol, Tegretol); efavirenz (Sustiva, in Atripla); modafinil (Provigil); nalbuphine (Nubain); naloxone (Evzio, Narcan); nevirapine (Viramune); oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos); oxcarbazepine (Trileptal); pentazocine (Talwin); phenytoin (Dilantin, Phenytek); pioglitazone (Actos, in Actoplus Met, in Duetact); rifabutin (Mycobutin); and rifampin (Rifadin, Rimactane, in Rifamate, in Rifater). Also tell your doctor or pharmacist if you are taking any of the following medications or if you have stopped taking them within the past two weeks: monoamine oxidase (MAO) inhibitors including isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor what herbal products you are taking, especially St. John's wort.

  • tell your doctor if you or anyone in your family drinks or has ever drunk large amounts of alcohol or uses or has ever used street drugs or excessive amounts of prescription medications. Also tell your doctor if you have or have ever had a head injury, a brain tumor, a stroke, or any other condition that caused high pressure inside your skull; seizures; slowed heartbeat or other heart problems; low blood pressure; mental problems such as depression, schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions), or hallucinations (seeing things or hearing voices that do not exist); breathing problems such as asthma and chronic obstructive pulmonary disease (COPD; a group of lung diseases that includes chronic bronchitis and emphysema); or kidney or liver disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while using fentanyl, call your doctor.

  • you should know that this medication may decrease fertility in men and women. Talk to your doctor about the risks of using fentanyl.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are using fentanyl.

  • you should know that fentanyl may make you drowsy or dizzy. Do not drive a car or operate machinery until you know how this medication affects you.

  • you should know that fentanyl may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. This is more common when you first start using fentanyl. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.

  • if you have diabetes, you should know that each fentanyl lozenge (Actiq) contains about 2 grams of sugar.

  • if you will be using the lozenges (Actiq), talk to your dentist about the best way to care for your teeth during your treatment. The lozenges contain sugar and may cause tooth decay and other dental problems.

  • you should know that fentanyl may cause constipation. Talk to your doctor about changing your diet and using other medications to treat or prevent constipation.

Do not eat grapefruit or drink grapefruit juice while using this medication.

This medication is usually used as needed according to directions.

  • Fentanyl may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • drowsiness

    • stomach pain

    • gas

    • heartburn

    • weight loss

    • difficulty urinating

    • changes in vision

    • anxiety

    • depression

    • unusual thinking

    • unusual dreams

    • difficulty falling asleep or staying asleep

    • dry mouth

    • sudden reddening of the face, neck, or upper chest

    • uncontrollable shaking of a part of the body

    • back pain

    • chest pain

    • pain, sores, or irritation in the mouth in the area where you placed the medication

    • swelling of the hands, arms, feet, ankles, or lower legs

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

    • changes in heartbeat

    • agitation, hallucinations (seeing things or hearing voices that do not exist), fever, sweating, confusion, fast heartbeat, shivering, severe muscle stiffness or twitching, loss of coordination, nausea, vomiting, or diarrhea

    • nausea, vomiting, loss of appetite, weakness, or dizziness

    • inability to get or keep an erection

    • irregular menstruation

    • decreased sexual desire

    • seizures

    • hives

    • rash

    • itching

  • If you experience any of these symptoms, stop using fentanyl and call your doctor immediately or get emergency medical treatment:

    • slow, shallow breathing

    • decreased urge to breathe

    • difficulty breathing or swallowing

    • extreme drowsiness

    • dizziness

    • confusion

    • fainting

  • Fentanyl may cause other side effects. Call your doctor if you have any unusual problems while using this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the packaging it came in, tightly closed, and out of reach of children. Store fentanyl in a safe place so that no one else can use it accidentally or on purpose. Use the child-resistant locks and other supplies provided by the manufacturer to keep children away from the lozenges. Keep track of how much fentanyl is left so you will know if any is missing. Store fentanyl at room temperature and away from excess heat and moisture (not in the bathroom). Do not freeze fentanyl.

You must immediately dispose of any medication that is outdated or no longer needed through a medicine take-back program.. If you do not have a take-back program nearby or one that you can access promptly, then flush the fentanyl down the toilet so that others will not take it. Dispose of unneeded lozenges by removing each lozenge from the blister package, holding the lozenge over the toilet, and cutting off the medicine end with wire cutters so that it falls into the toilet. Throw away the remaining handles in a place that is out of the reach of children and pets, and flush the toilet twice when it contains up to five lozenges. Dispose of unneeded tablets or films by removing them from the packaging and flushing them down the toilet. Throw the remaining fentanyl packaging or cartons into a trash container; do not flush these items down the toilet. Call your pharmacist or the manufacturer if you have questions or need help disposing of unneeded medication.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, remove the fentanyl from the victim's mouth and call local emergency services at 911.

While using fentanyl, you should talk to your doctor about having a rescue medication called naloxone readily available (e.g., home, office). Naloxone is used to reverse the life-threatening effects of an overdose. It works by blocking the effects of opiates to relieve dangerous symptoms caused by high levels of opiates in the blood. Your doctor may also prescribe you naloxone if you are living in a household where there are small children or someone who has abused street or prescription drugs. You should make sure that you and your family members, caregivers, or the people who spend time with you know how to tell recognize an overdose, how to use naloxone, and what to do until emergency medical help arrives. Your doctor or pharmacist will show you and your family members how to use the medication. Ask your pharmacist for the instructions or visit the manufacturer's website to get the instructions. If symptoms of an overdose occur, a friend or family member should give the first dose of naloxone, call 911 immediately, and stay with you and watch you closely until emergency medical help arrives. Your symptoms may return within a few minutes after you receive naloxone. If your symptoms return, the person should give you another dose of naloxone. Additional doses may be given every 2 to 3 minutes, if symptoms return before medical help arrives.

Symptoms of overdose may include the following:

  • drowsiness or sleepiness

  • dizziness

  • confusion

  • slow, shallow breathing or stopped breathing

  • difficulty breathing

  • smaller pupils (black circles in the middle of the eyes)

  • unable to respond or wake up

Keep all appointments with your doctor.

Do not let anyone else use your medication, even if he or she has the same symptoms that you have. Selling or giving away this medication may cause severe harm or death to others and is against the law.

This prescription is not refillable. Be sure to schedule appointments with your doctor on a regular basis so that you do not run out of medication.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Delavirdine Delavirdine The metabolism of Fentanyl can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Fentanyl can be decreased when combined with Nevirapine.
Atorvastatin Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Fentanyl.
Dolasetron Dolasetron The risk or severity of adverse effects can be increased when Dolasetron is combined with Fentanyl.
Bisacodyl Bisacodyl The therapeutic efficacy of Bisacodyl can be decreased when used in combination with Fentanyl.
Candesartan Candesartan Fentanyl may decrease the antihypertensive activities of Candesartan.
Cilostazol Cilostazol The metabolism of Cilostazol can be decreased when combined with Fentanyl.
Clopidogrel Clopidogrel Fentanyl can cause a decrease in the absorption of Clopidogrel resulting in a reduced serum concentration and potentially a decrease in efficacy.
Diphenoxylate Diphenoxylate The risk or severity of adverse effects can be increased when Fentanyl is combined with Diphenoxylate.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The metabolism of Fentanyl can be decreased when combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Conjugated estrogens may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Fenofibrate Fenofibrate Fentanyl may decrease the excretion rate of Fenofibrate which could result in a higher serum level.
Guanfacine Guanfacine The risk or severity of adverse effects can be increased when Fentanyl is combined with Guanfacine.
Magnesium Hydroxide Magnesium Hydroxide The therapeutic efficacy of Magnesium hydroxide can be decreased when used in combination with Fentanyl.
Magnesium Oxide Magnesium Oxide The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Fentanyl.
Methylergonovine Methylergonovine The metabolism of Fentanyl can be decreased when combined with Methylergometrine.
Mycophenolate Mycophenolate Fentanyl may decrease the excretion rate of Mycophenolic acid which could result in a higher serum level.
Naratriptan Naratriptan The risk or severity of adverse effects can be increased when Fentanyl is combined with Naratriptan.
Olsalazine Olsalazine Fentanyl may decrease the excretion rate of Olsalazine which could result in a higher serum level.
Paregoric Paregoric The risk or severity of adverse effects can be increased when Morphine is combined with Fentanyl.
Penbutolol Penbutolol Fentanyl may decrease the antihypertensive activities of Acebutolol.
Pentazocine Pentazocine The therapeutic efficacy of Fentanyl can be decreased when used in combination with Pentazocine.
Polyethylene glycol-electrolyte solution (PEG-ES) Polyethylene glycol-electrolyte solution (PEG-ES) The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Fentanyl.
Potassium Potassium Fentanyl may increase the excretion rate of Potassium cation which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone Prednisone Prednisone may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Psyllium Psyllium The therapeutic efficacy of Plantago seed can be decreased when used in combination with Fentanyl.
Ranitidine Ranitidine Fentanyl may decrease the excretion rate of Ranitidine which could result in a higher serum level.
Reserpine Reserpine The risk or severity of adverse effects can be increased when Fentanyl is combined with Reserpine.
Rizatriptan Rizatriptan The risk or severity of adverse effects can be increased when Fentanyl is combined with Rizatriptan.
Sumatriptan Sumatriptan The risk or severity of adverse effects can be increased when Sumatriptan is combined with Fentanyl.
Tacrolimus Tacrolimus The metabolism of Fentanyl can be decreased when combined with Tacrolimus.
Tizanidine Tizanidine The risk or severity of adverse effects can be increased when Tizanidine is combined with Fentanyl.
Triamcinolone Triamcinolone The metabolism of Fentanyl can be increased when combined with Triamcinolone.
Zolmitriptan Zolmitriptan The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Fentanyl.
Ampicillin Injection Ampicillin Injection Ampicillin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Doxycycline Injection Doxycycline Injection Doxycycline may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Fluconazole Injection Fluconazole Injection The metabolism of Fentanyl can be decreased when combined with Fluconazole.
Foscarnet Injection Foscarnet Injection Foscarnet may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Hydromorphone Injection Hydromorphone Injection The risk or severity of adverse effects can be increased when Hydromorphone is combined with Fentanyl.
Levofloxacin Injection Levofloxacin Injection Fentanyl may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Meperidine Injection Meperidine Injection The risk or severity of adverse effects can be increased when Meperidine is combined with Fentanyl.
Metoclopramide Injection Metoclopramide Injection The therapeutic efficacy of Metoclopramide can be decreased when used in combination with Fentanyl.
Metronidazole Injection Metronidazole Injection The metabolism of Fentanyl can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection The risk or severity of adverse effects can be increased when Morphine is combined with Fentanyl.
Pamidronate Injection Pamidronate Injection Pamidronic acid may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Vancomycin Injection Vancomycin Injection Fentanyl may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Altretamine Altretamine The risk or severity of adverse effects can be increased when Amphetamine is combined with Fentanyl.
Cefuroxime Cefuroxime Cefuroxime may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Cyclosporine Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Fentanyl.
Ondansetron Ondansetron The risk or severity of adverse effects can be increased when Fentanyl is combined with Ondansetron.
Granisetron Granisetron The risk or severity of adverse effects can be increased when Fentanyl is combined with Granisetron.
Torsemide Torsemide The therapeutic efficacy of Torasemide can be decreased when used in combination with Fentanyl.
Olanzapine Olanzapine The risk or severity of adverse effects can be increased when Fentanyl is combined with Olanzapine.
Alosetron Alosetron The risk or severity of adverse effects can be increased when Fentanyl is combined with Alosetron.
Entacapone Entacapone The risk or severity of adverse effects can be increased when Entacapone is combined with Fentanyl.
Eprosartan Eprosartan Fentanyl may decrease the antihypertensive activities of Eprosartan.
Meloxicam Meloxicam Fentanyl may decrease the excretion rate of Meloxicam which could result in a higher serum level.
Oxcarbazepine Oxcarbazepine The metabolism of Fentanyl can be decreased when combined with Oxcarbazepine.
Pantoprazole Pantoprazole Pantoprazole may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Telmisartan Telmisartan Fentanyl may decrease the antihypertensive activities of Telmisartan.
Temozolomide Temozolomide Fentanyl may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Zaleplon Zaleplon The risk or severity of adverse effects can be increased when Fentanyl is combined with Zaleplon.
Anakinra Anakinra The metabolism of Fentanyl can be increased when combined with Anakinra.
Desloratadine Desloratadine The risk or severity of adverse effects can be increased when Fentanyl is combined with Desloratadine.
Linezolid Linezolid The risk or severity of serotonin syndrome can be increased when Linezolid is combined with Fentanyl.
Rivastigmine Rivastigmine Fentanyl may increase the bradycardic activities of Rivastigmine.
Trimipramine Trimipramine The risk or severity of adverse effects can be increased when Trimipramine is combined with Fentanyl.
Etanercept Injection Etanercept Injection The metabolism of Fentanyl can be increased when combined with Etanercept.
Glycopyrrolate Glycopyrrolate The risk or severity of adverse effects can be increased when Fentanyl is combined with Glycopyrronium.
Modafinil Modafinil The metabolism of Fentanyl can be increased when combined with Modafinil.
Perindopril Perindopril Fentanyl may decrease the antihypertensive activities of Perindopril.
Tenofovir Tenofovir Tenofovir may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate Fentanyl may decrease the excretion rate of Choline magnesium trisalicylate which could result in a higher serum level.
Sirolimus Sirolimus The metabolism of Sirolimus can be decreased when combined with Fentanyl.
Dutasteride Dutasteride The metabolism of Dutasteride can be decreased when combined with Fentanyl.
Epinephrine Injection Epinephrine Injection The metabolism of Fentanyl can be decreased when combined with Epinephrine.
Eplerenone Eplerenone Fentanyl may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Escitalopram Escitalopram The risk or severity of serotonin syndrome can be increased when Escitalopram is combined with Fentanyl.
Olmesartan Olmesartan Fentanyl may decrease the antihypertensive activities of Olmesartan.
Zonisamide Zonisamide The risk or severity of adverse effects can be increased when Fentanyl is combined with Zonisamide.
Adalimumab Injection Adalimumab Injection The metabolism of Fentanyl can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The risk or severity of adverse effects can be increased when Aripiprazole is combined with Fentanyl.
Atomoxetine Atomoxetine The risk or severity of adverse effects can be increased when Atomoxetine is combined with Fentanyl.
Dexmethylphenidate Dexmethylphenidate The risk or severity of adverse effects can be increased when Fentanyl is combined with Dexmethylphenidate.
Atazanavir Atazanavir The metabolism of Fentanyl can be decreased when combined with Atazanavir.
Almotriptan Almotriptan The risk or severity of adverse effects can be increased when Fentanyl is combined with Almotriptan.
Eletriptan Eletriptan The risk or severity of adverse effects can be increased when Eletriptan is combined with Fentanyl.
Mefloquine Mefloquine The metabolism of Fentanyl can be decreased when combined with Mefloquine.
Polyethylene Glycol 3350 Polyethylene Glycol 3350 The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Fentanyl.
Rosuvastatin Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Fentanyl.
Vardenafil Vardenafil The metabolism of Vardenafil can be decreased when combined with Fentanyl.
Aprepitant Aprepitant The metabolism of Fentanyl can be decreased when combined with Aprepitant.
Emtricitabine Emtricitabine Fentanyl may decrease the excretion rate of Emtricitabine which could result in a higher serum level.
Memantine Memantine Fentanyl may decrease the excretion rate of Memantine which could result in a higher serum level.
Tegaserod Tegaserod The risk or severity of serotonin syndrome can be increased when Fentanyl is combined with Tegaserod.
Tadalafil Tadalafil Fentanyl may decrease the antihypertensive activities of Tadalafil.
Frovatriptan Frovatriptan The risk or severity of adverse effects can be increased when Fentanyl is combined with Frovatriptan.
Progesterone Progesterone The metabolism of Fentanyl can be decreased when combined with Progesterone.
Apomorphine Injection Apomorphine Injection The risk or severity of adverse effects can be increased when Apomorphine is combined with Fentanyl.
Infliximab Injection Infliximab Injection The metabolism of Fentanyl can be increased when combined with Infliximab.
Protriptyline Protriptyline The risk or severity of adverse effects can be increased when Protriptyline is combined with Fentanyl.
Duloxetine Duloxetine The metabolism of Fentanyl can be decreased when combined with Duloxetine.
Norethindrone Norethindrone The metabolism of Fentanyl can be decreased when combined with Norethisterone.
Tinidazole Tinidazole Fentanyl may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Trospium Trospium The risk or severity of adverse effects can be increased when Fentanyl is combined with Trospium.
Bosentan Bosentan Fentanyl may decrease the antihypertensive activities of Bosentan.
Cefditoren Cefditoren Cefdinir may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Cyanocobalamin Injection Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Erlotinib Erlotinib The metabolism of Fentanyl can be decreased when combined with Erlotinib.
Eszopiclone Eszopiclone The risk or severity of CNS depression can be increased when Fentanyl is combined with Eszopiclone.
Ganciclovir Ganciclovir Fentanyl may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Ribavirin Ribavirin Ribavirin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Solifenacin Solifenacin The risk or severity of adverse effects can be increased when Solifenacin is combined with Fentanyl.
Valganciclovir Valganciclovir Fentanyl may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Voriconazole Voriconazole The metabolism of Fentanyl can be decreased when combined with Voriconazole.
Adefovir Adefovir Adefovir may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Dextroamphetamine Dextroamphetamine The risk or severity of adverse effects can be increased when Amphetamine is combined with Fentanyl.
Sodium Oxybate Sodium Oxybate Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Fentanyl.
Isocarboxazid Isocarboxazid The risk or severity of adverse effects can be increased when Isocarboxazid is combined with Fentanyl.
Ramelteon Ramelteon The risk or severity of adverse effects can be increased when Fentanyl is combined with Ramelteon.
Darifenacin Darifenacin The risk or severity of adverse effects can be increased when Darifenacin is combined with Fentanyl.
Pregabalin Pregabalin The therapeutic efficacy of Fentanyl can be increased when used in combination with Pregabalin.
Phenylephrine Phenylephrine The therapeutic efficacy of Fentanyl can be decreased when used in combination with Phenylephrine.
Tipranavir Tipranavir The metabolism of Fentanyl can be decreased when combined with Tipranavir.
Felbamate Felbamate The risk or severity of adverse effects can be increased when Fentanyl is combined with Felbamate.
Ranolazine Ranolazine The metabolism of Ranolazine can be decreased when combined with Fentanyl.
Abatacept Injection Abatacept Injection The metabolism of Fentanyl can be increased when combined with Abatacept.
Rasagiline Rasagiline The risk or severity of adverse effects can be increased when Rasagiline is combined with Fentanyl.
Imatinib Imatinib The metabolism of Fentanyl can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin Fentanyl may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Varenicline Varenicline Fentanyl may decrease the excretion rate of Varenicline which could result in a higher serum level.
Gefitinib Gefitinib The metabolism of Fentanyl can be decreased when combined with Gefitinib.
Albuterol Albuterol The risk or severity of hypertension can be increased when Fentanyl is combined with Salbutamol.
Paliperidone Paliperidone The risk or severity of adverse effects can be increased when Fentanyl is combined with Paliperidone.
Clofarabine Injection Clofarabine Injection Clofarabine may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Lubiprostone Lubiprostone The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Fentanyl.
Posaconazole Posaconazole The metabolism of Fentanyl can be decreased when combined with Posaconazole.
Primaquine Primaquine The metabolism of Fentanyl can be decreased when combined with Primaquine.
Aliskiren Aliskiren Fentanyl may decrease the antihypertensive activities of Aliskiren.
Darunavir Darunavir The metabolism of Fentanyl can be decreased when combined with Darunavir.
Pemetrexed Injection Pemetrexed Injection Pemetrexed may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Dimenhydrinate Dimenhydrinate The risk or severity of adverse effects can be increased when Fentanyl is combined with Dimenhydrinate.
Lisdexamfetamine Lisdexamfetamine Lisdexamfetamine may increase the analgesic activities of Fentanyl.
Nabilone Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Fentanyl.
Sorafenib Sorafenib The metabolism of Fentanyl can be decreased when combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Fentanyl can be decreased when combined with Sunitinib.
Dronabinol Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Fentanyl.
Lapatinib Lapatinib The metabolism of Fentanyl can be decreased when combined with Lapatinib.
Levocetirizine Levocetirizine The risk or severity of adverse effects can be increased when Fentanyl is combined with Levocetirizine.
Pegaptanib Injection Pegaptanib Injection Fentanyl may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Dasatinib Dasatinib The metabolism of Fentanyl can be decreased when combined with Dasatinib.
Armodafinil Armodafinil The metabolism of Fentanyl can be increased when combined with Armodafinil.
Azacitidine Injection Azacitidine Injection Fentanyl may decrease the excretion rate of Azacitidine which could result in a higher serum level.
Paclitaxel (with polyoxyethylated castor oil) Injection Paclitaxel (with polyoxyethylated castor oil) Injection The therapeutic efficacy of Castor oil can be decreased when used in combination with Fentanyl.
Temsirolimus Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Fentanyl.
Lenalidomide Lenalidomide Lenalidomide may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Nilotinib Nilotinib The metabolism of Fentanyl can be decreased when combined with Nilotinib.
Budesonide Budesonide The metabolism of Fentanyl can be increased when combined with Budesonide.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Fentanyl can be decreased when combined with Chloramphenicol.
Desmopressin Desmopressin The risk or severity of hyponatremia can be increased when Fentanyl is combined with Desmopressin.
OnabotulinumtoxinA Injection OnabotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Fentanyl.
RimabotulinumtoxinB Injection RimabotulinumtoxinB Injection The risk or severity of adverse effects can be increased when Botulinum Toxin Type B is combined with Fentanyl.
Doripenem Injection Doripenem Injection Fentanyl may decrease the excretion rate of Doripenem which could result in a higher serum level.
Arsenic Trioxide Injection Arsenic Trioxide Injection Fentanyl may decrease the excretion rate of Arsenic trioxide which could result in a higher serum level.
Mitoxantrone Injection Mitoxantrone Injection The metabolism of Fentanyl can be decreased when combined with Mitoxantrone.
Desvenlafaxine Desvenlafaxine The metabolism of Fentanyl can be decreased when combined with Desvenlafaxine.
Cevimeline Cevimeline Cevimeline may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Nebivolol Nebivolol Fentanyl may decrease the antihypertensive activities of Nebivolol.
Tretinoin Tretinoin The metabolism of Fentanyl can be decreased when combined with Tretinoin.
Pilocarpine Pilocarpine The metabolism of Fentanyl can be decreased when combined with Pilocarpine.
Certolizumab Injection Certolizumab Injection The metabolism of Fentanyl can be increased when combined with Certolizumab pegol.
Irinotecan Injection Irinotecan Injection The metabolism of Fentanyl can be decreased when combined with Irinotecan.
Daptomycin Injection Daptomycin Injection Daptomycin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Praziquantel Praziquantel The metabolism of Praziquantel can be decreased when combined with Fentanyl.
Alvimopan Alvimopan The risk or severity of adverse effects can be increased when Fentanyl is combined with Alvimopan.
Methylnaltrexone Injection Methylnaltrexone Injection The therapeutic efficacy of Methylnaltrexone can be decreased when used in combination with Fentanyl.
Rufinamide Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Fentanyl.
Midazolam Midazolam The metabolism of Fentanyl can be decreased when combined with Midazolam.
Naltrexone Injection Naltrexone Injection The risk or severity of adverse effects can be increased when Naltrexone is combined with Fentanyl.
Dexrazoxane Injection Dexrazoxane Injection Dexrazoxane may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Milnacipran Milnacipran The metabolism of Fentanyl can be decreased when combined with Milnacipran.
Plerixafor Injection Plerixafor Injection Fentanyl may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Sodium Phosphate Sodium Phosphate The therapeutic efficacy of Sodium phosphate, monobasic can be decreased when used in combination with Fentanyl.
Fesoterodine Fesoterodine The risk or severity of adverse effects can be increased when Fesoterodine is combined with Fentanyl.
Betaxolol Betaxolol Betaxolol may increase the bradycardic activities of Fentanyl.
Iloperidone Iloperidone The risk or severity of adverse effects can be increased when Fentanyl is combined with Iloperidone.
Prasugrel Prasugrel Fentanyl may decrease the excretion rate of Prasugrel which could result in a higher serum level.
Lacosamide Lacosamide The risk or severity of adverse effects can be increased when Fentanyl is combined with Lacosamide.
Everolimus Everolimus The metabolism of Everolimus can be decreased when combined with Fentanyl.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) Tolvaptan may increase the excretion rate of Fentanyl which could result in a lower serum level and potentially a reduction in efficacy.
Dronedarone Dronedarone The metabolism of Fentanyl can be decreased when combined with Dronedarone.
AbobotulinumtoxinA Injection AbobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Fentanyl.
Pralatrexate Injection Pralatrexate Injection Fentanyl may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Palonosetron Injection Palonosetron Injection The risk or severity of adverse effects can be increased when Palonosetron is combined with Fentanyl.
Saxagliptin Saxagliptin The metabolism of Saxagliptin can be decreased when combined with Fentanyl.
Telavancin Injection Telavancin Injection Fentanyl may decrease the excretion rate of Telavancin which could result in a higher serum level.
Romidepsin Injection Romidepsin Injection The metabolism of Romidepsin can be decreased when combined with Fentanyl.
Tapentadol Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Fentanyl.
Topotecan Topotecan The metabolism of Fentanyl can be decreased when combined with Topotecan.
Golimumab Injection Golimumab Injection The metabolism of Fentanyl can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Fentanyl can be decreased when combined with Pazopanib.
Asenapine Asenapine The risk or severity of adverse effects can be increased when Fentanyl is combined with Asenapine.
Vigabatrin Vigabatrin The risk or severity of adverse effects can be increased when Fentanyl is combined with Vigabatrin.
Levonorgestrel Levonorgestrel The metabolism of Fentanyl can be decreased when combined with Levonorgestrel.
Oxymorphone Oxymorphone The risk or severity of adverse effects can be increased when Fentanyl is combined with Oxymorphone.
Tocilizumab Injection Tocilizumab Injection The metabolism of Fentanyl can be increased when combined with Tocilizumab.
Dalfampridine Dalfampridine The risk or severity of seizure can be increased when Dalfampridine is combined with Fentanyl.
Fingolimod Fingolimod Fentanyl may increase the bradycardic activities of Fingolimod.
IncobotulinumtoxinA Injection IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Fentanyl.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Cabazitaxel can be decreased when combined with Fentanyl.
Ceftaroline Injection Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Lurasidone Lurasidone The risk or severity of adverse effects can be increased when Fentanyl is combined with Lurasidone.
Acetaminophen Injection Acetaminophen Injection The metabolism of Fentanyl can be decreased when combined with Acetaminophen.
Vilazodone Vilazodone The risk or severity of adverse effects can be increased when Fentanyl is combined with Vilazodone.
Ipilimumab Injection Ipilimumab Injection Fentanyl may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Denileukin Diftitox Injection Denileukin Diftitox Injection The metabolism of Fentanyl can be decreased when combined with Aldesleukin.
Terbutaline Injection Terbutaline Injection The risk or severity of hypertension can be increased when Fentanyl is combined with Terbutaline.
Roflumilast Roflumilast Fentanyl may decrease the excretion rate of Roflumilast which could result in a higher serum level.
Linagliptin Linagliptin The metabolism of Fentanyl can be decreased when combined with Linagliptin.
Rilpivirine Rilpivirine The metabolism of Fentanyl can be decreased when combined with Rilpivirine.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Fentanyl can be decreased when combined with Cyclophosphamide.
Rivaroxaban Rivaroxaban The metabolism of Rivaroxaban can be decreased when combined with Fentanyl.
Ticagrelor Ticagrelor The metabolism of Fentanyl can be decreased when combined with Ticagrelor.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Fentanyl can be decreased when combined with Brentuximab vedotin.
Ruxolitinib Ruxolitinib Ruxolitinib may increase the bradycardic activities of Fentanyl.
Clobazam Clobazam The risk or severity of adverse effects can be increased when Fentanyl is combined with Clobazam.
Ivacaftor Ivacaftor The metabolism of Fentanyl can be decreased when combined with Ivacaftor.
Deferiprone Deferiprone Fentanyl may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Axitinib Axitinib The metabolism of Axitinib can be decreased when combined with Fentanyl.
Crizotinib Crizotinib The metabolism of Fentanyl can be decreased when combined with Crizotinib.
Cabergoline Cabergoline The metabolism of Fentanyl can be decreased when combined with Cabergoline.
Naloxone Injection Naloxone Injection The metabolism of Fentanyl can be decreased when combined with Naloxone.
Ambrisentan Ambrisentan Fentanyl may decrease the antihypertensive activities of Ambrisentan.
Fondaparinux Injection Fondaparinux Injection Fondaparinux may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Ezogabine Ezogabine The risk or severity of adverse effects can be increased when Fentanyl is combined with Tiagabine.
Enzalutamide Enzalutamide The metabolism of Enzalutamide can be decreased when combined with Fentanyl.
Mirabegron Mirabegron The risk or severity of hypertension can be increased when Fentanyl is combined with Mirabegron.
Regorafenib Regorafenib The metabolism of Fentanyl can be decreased when combined with Regorafenib.
Bosutinib Bosutinib The metabolism of Fentanyl can be decreased when combined with Bosutinib.
Linaclotide Linaclotide The therapeutic efficacy of Linaclotide can be decreased when used in combination with Fentanyl.
Teduglutide Injection Teduglutide Injection Fentanyl may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Tofacitinib Tofacitinib Fentanyl may increase the bradycardic activities of Tofacitinib.
Alogliptin Alogliptin Fentanyl may decrease the excretion rate of Alogliptin which could result in a higher serum level.
Ponatinib Ponatinib The metabolism of Ponatinib can be decreased when combined with Fentanyl.
Pomalidomide Pomalidomide The risk or severity of adverse effects can be increased when Fentanyl is combined with Pomalidomide.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Fentanyl can be decreased when combined with Trastuzumab emtansine.
Apixaban Apixaban The metabolism of Apixaban can be decreased when combined with Fentanyl.
Canagliflozin Canagliflozin Fentanyl may increase the excretion rate of Canagliflozin which could result in a lower serum level and potentially a reduction in efficacy.
Methazolamide Methazolamide The therapeutic efficacy of Methazolamide can be decreased when used in combination with Fentanyl.
Trametinib Trametinib Fentanyl may decrease the excretion rate of Trametinib which could result in a higher serum level.
Levomilnacipran Levomilnacipran The risk or severity of serotonin syndrome can be increased when Levomilnacipran is combined with Fentanyl.
Ertapenem Injection Ertapenem Injection Ertapenem may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Vortioxetine Vortioxetine The risk or severity of adverse effects can be increased when Fentanyl is combined with Vortioxetine.
Perampanel Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Fentanyl.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Fentanyl.
Lomitapide Lomitapide The metabolism of Fentanyl can be decreased when combined with Lomitapide.
Ketorolac Injection Ketorolac Injection Ketorolac may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Simeprevir Simeprevir The metabolism of Fentanyl can be decreased when combined with Simeprevir.
Sofosbuvir Sofosbuvir Fentanyl may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin Dapagliflozin Dapagliflozin may increase the excretion rate of Fentanyl which could result in a lower serum level and potentially a reduction in efficacy.
Apremilast Apremilast The metabolism of Fentanyl can be increased when combined with Apremilast.
Droxidopa Droxidopa The therapeutic efficacy of Fentanyl can be decreased when used in combination with Droxidopa.
Ceritinib Ceritinib The metabolism of Fentanyl can be decreased when combined with Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Fentanyl can be decreased when combined with Siltuximab.
Eslicarbazepine Eslicarbazepine The risk or severity of adverse effects can be increased when Fentanyl is combined with Eslicarbazepine.
Idelalisib Idelalisib The metabolism of Fentanyl can be decreased when combined with Idelalisib.
Testosterone Injection Testosterone Injection The metabolism of Fentanyl can be decreased when combined with Testosterone.
Hydrocodone Hydrocodone Hydrocodone may increase the central nervous system depressant (CNS depressant) activities of Fentanyl.
Suvorexant Suvorexant Fentanyl may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Edoxaban Edoxaban Fentanyl may decrease the excretion rate of Edoxaban which could result in a higher serum level.
Olaparib Olaparib The metabolism of Fentanyl can be decreased when combined with Olaparib.
Methamphetamine Methamphetamine The risk or severity of adverse effects can be increased when Fentanyl is combined with Metamfetamine.
Tasimelteon Tasimelteon The risk or severity of adverse effects can be increased when Fentanyl is combined with Tasimelteon.
Riociguat Riociguat Fentanyl may decrease the antihypertensive activities of Riociguat.
Lanreotide Injection Lanreotide Injection The metabolism of Fentanyl can be decreased when combined with Lanreotide.
Secukinumab Injection Secukinumab Injection The metabolism of Fentanyl can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The risk or severity of adverse effects can be increased when Risperidone is combined with Fentanyl.
Palbociclib Palbociclib The metabolism of Fentanyl can be decreased when combined with Palbociclib.
Lenvatinib Lenvatinib The metabolism of Fentanyl can be decreased when combined with Lenvatinib.
Naloxegol Naloxegol The therapeutic efficacy of Fentanyl can be decreased when used in combination with Naloxegol.
Haloperidol Injection Haloperidol Injection The metabolism of Fentanyl can be decreased when combined with Haloperidol.
Ivabradine Ivabradine Fentanyl may increase the bradycardic activities of Ivabradine.
Amiloride Amiloride Amiloride may increase the excretion rate of Fentanyl which could result in a lower serum level and potentially a reduction in efficacy.
Isavuconazonium Injection Isavuconazonium Injection The metabolism of Fentanyl can be decreased when combined with Isavuconazonium.
Macitentan Macitentan Fentanyl may decrease the antihypertensive activities of Macitentan.
Flibanserin Flibanserin The risk or severity of adverse effects can be increased when Fentanyl is combined with Flibanserin.
Daclatasvir Daclatasvir The metabolism of Daclatasvir can be decreased when combined with Fentanyl.
Brexpiprazole Brexpiprazole The risk or severity of adverse effects can be increased when Fentanyl is combined with Brexpiprazole.
Ziprasidone Injection Ziprasidone Injection The metabolism of Fentanyl can be decreased when combined with Ziprasidone.
Cariprazine Cariprazine The risk or severity of adverse effects can be increased when Fentanyl is combined with Cariprazine.
Penicillin G Procaine Injection Penicillin G Procaine Injection Fentanyl may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Eluxadoline Eluxadoline The risk or severity of constipation can be increased when Fentanyl is combined with Eluxadoline.
Osimertinib Osimertinib The metabolism of Fentanyl can be decreased when combined with Osimertinib.
Ixazomib Ixazomib Fentanyl may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Lesinurad Lesinurad Fentanyl may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The metabolism of Fentanyl can be decreased when combined with Amphotericin B.
Dexamethasone Injection Dexamethasone Injection The metabolism of Fentanyl can be decreased when combined with Dexamethasone.
Brivaracetam Injection Brivaracetam Injection The risk or severity of adverse effects can be increased when Fentanyl is combined with Brivaracetam.
Venetoclax Venetoclax The metabolism of Fentanyl can be decreased when combined with Venetoclax.
Cobicistat Cobicistat The metabolism of Fentanyl can be decreased when combined with Cobicistat.
Midodrine Midodrine The therapeutic efficacy of Fentanyl can be decreased when used in combination with Midodrine.
Selexipag Selexipag Fentanyl may decrease the antihypertensive activities of Selexipag.
Pimavanserin Pimavanserin The risk or severity of adverse effects can be increased when Fentanyl is combined with Pimavanserin.
Diphenhydramine Injection Diphenhydramine Injection The risk or severity of adverse effects can be increased when Fentanyl is combined with Diphenhydramine.
Furosemide Injection Furosemide Injection Fentanyl may decrease the excretion rate of Furosemide which could result in a higher serum level.
Rucaparib Rucaparib The metabolism of Fentanyl can be decreased when combined with Rucaparib.
Lixisenatide Injection Lixisenatide Injection Fentanyl may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Ribociclib Ribociclib The metabolism of Fentanyl can be decreased when combined with Ribociclib.
Doxepin (Insomnia) Doxepin (Insomnia) The risk or severity of adverse effects can be increased when Fentanyl is combined with Doxepin.
Plecanatide Plecanatide The therapeutic efficacy of Plecanatide can be decreased when used in combination with Fentanyl.
Deutetrabenazine Deutetrabenazine The metabolism of Deutetrabenazine can be decreased when combined with Fentanyl.
Valbenazine Valbenazine The metabolism of Valbenazine can be decreased when combined with Fentanyl.
Deflazacort Deflazacort The metabolism of Fentanyl can be increased when combined with Deflazacort.
Safinamide Safinamide The risk or severity of adverse effects can be increased when Safinamide is combined with Fentanyl.
Naldemedine Naldemedine The therapeutic efficacy of Naldemedine can be decreased when used in combination with Fentanyl.
Sarilumab Injection Sarilumab Injection The metabolism of Fentanyl can be decreased when combined with Sarilumab.
Midostaurin Midostaurin The metabolism of Fentanyl can be decreased when combined with Midostaurin.
Enasidenib Enasidenib The metabolism of Fentanyl can be decreased when combined with Enasidenib.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Fentanyl can be decreased when combined with Fosaprepitant.
Benznidazole Benznidazole Fentanyl may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Copanlisib Injection Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Fentanyl.
Delafloxacin Delafloxacin Fentanyl may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Acalabrutinib Acalabrutinib The metabolism of Fentanyl can be decreased when combined with Acalabrutinib.
Letermovir Letermovir The metabolism of Fentanyl can be decreased when combined with Letermovir.
Ertugliflozin Ertugliflozin Ertugliflozin may increase the excretion rate of Fentanyl which could result in a lower serum level and potentially a reduction in efficacy.
Buprenorphine Injection Buprenorphine Injection The metabolism of Fentanyl can be decreased when combined with Buprenorphine.
Apalutamide Apalutamide Fentanyl may decrease the excretion rate of Apalutamide which could result in a higher serum level.
Fostamatinib Fostamatinib The metabolism of Fentanyl can be decreased when combined with Fostamatinib.
Baricitinib Baricitinib Fentanyl may decrease the excretion rate of Baricitinib which could result in a higher serum level.
Lofexidine Lofexidine The therapeutic efficacy of Fentanyl can be increased when used in combination with Lofexidine.
Plazomicin Injection Plazomicin Injection Fentanyl may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Doravirine Doravirine The metabolism of Doravirine can be decreased when combined with Fentanyl.
Cannabidiol Cannabidiol The risk or severity of adverse effects can be increased when Cannabidiol is combined with Fentanyl.
Stiripentol Stiripentol The metabolism of Fentanyl can be decreased when combined with Stiripentol.
Gilteritinib Gilteritinib The therapeutic efficacy of Fentanyl can be decreased when used in combination with Gilteritinib.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Fentanyl.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Fentanyl.
Rifamycin Rifamycin The metabolism of Fentanyl can be decreased when combined with Rifamycin.
Prucalopride Prucalopride The therapeutic efficacy of Prucalopride can be decreased when used in combination with Fentanyl.
Magnesium Citrate Magnesium Citrate The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Fentanyl.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Fentanyl can be increased when combined with Emapalumab.
Siponimod Siponimod The risk or severity of hypertension can be increased when Fentanyl is combined with Siponimod.
Acyclovir Ophthalmic Acyclovir Ophthalmic Acyclovir may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Alpelisib Alpelisib The metabolism of Fentanyl can be decreased when combined with Alpelisib.
Brexanolone Injection Brexanolone Injection The risk or severity of adverse effects can be increased when Fentanyl is combined with Brexanolone.
Solriamfetol Solriamfetol The risk or severity of hypertension can be increased when Solriamfetol is combined with Fentanyl.
Triclabendazole Triclabendazole The metabolism of Fentanyl can be decreased when combined with Triclabendazole.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Fentanyl.
Pitolisant Pitolisant The serum concentration of Fentanyl can be decreased when it is combined with Pitolisant.
Phenytoin Injection Phenytoin Injection The risk or severity of adverse effects can be increased when Phenytoin is combined with Fentanyl.
Fosphenytoin Injection Fosphenytoin Injection The risk or severity of adverse effects can be increased when Fentanyl is combined with Fosphenytoin.
Lumateperone Lumateperone The risk or severity of adverse effects can be increased when Fentanyl is combined with Lumateperone.
Lasmiditan Lasmiditan The risk or severity of serotonin syndrome can be increased when Fentanyl is combined with Lasmiditan.
Cenobamate Cenobamate The metabolism of Fentanyl can be decreased when combined with Cenobamate.
Selumetinib Selumetinib The metabolism of Selumetinib can be decreased when combined with Fentanyl.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Fentanyl.
Remdesivir Injection Remdesivir Injection The metabolism of Fentanyl can be decreased when combined with Remdesivir.
Selpercatinib Selpercatinib The risk or severity of hypertension can be increased when Fentanyl is combined with Selpercatinib.
Lemborexant Lemborexant The risk or severity of adverse effects can be increased when Fentanyl is combined with Lemborexant.
Fenfluramine Fenfluramine The risk or severity of serotonin syndrome can be increased when Fenfluramine is combined with Fentanyl.
Octreotide Octreotide The metabolism of Fentanyl can be decreased when combined with Octreotide.
Pralsetinib Pralsetinib The metabolism of Fentanyl can be decreased when combined with Pralsetinib.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Fentanyl can be decreased when it is combined with Satralizumab.
Naxitamab-gqgk Injection Naxitamab-gqgk Injection The risk or severity of hypertension can be increased when Fentanyl is combined with Naxitamab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives Drospirenone may increase the excretion rate of Fentanyl which could result in a lower serum level and potentially a reduction in efficacy.
Viloxazine Viloxazine The risk or severity of adverse effects can be increased when Fentanyl is combined with Viloxazine.
Tobramycin Injection Tobramycin Injection Tobramycin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Fenoprofen Fenoprofen Fenoprofen may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Indomethacin Indomethacin Indomethacin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Mefenamic Acid Mefenamic Acid Mefenamic acid may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Naproxen Naproxen Naproxen may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Tolmetin Tolmetin Tolmetin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Sulindac Sulindac Sulindac may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Trazodone Trazodone The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Fentanyl.
Isotretinoin Isotretinoin Fentanyl may decrease the excretion rate of Isotretinoin which could result in a higher serum level.
Sucralfate Sucralfate Sucralfate may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Floxuridine Floxuridine Floxuridine may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Phenobarbital Phenobarbital The risk or severity of adverse effects can be increased when Fentanyl is combined with Phenobarbital.
Metaxalone Metaxalone The risk or severity of adverse effects can be increased when Metaxalone is combined with Fentanyl.
Methotrexate Injection Methotrexate Injection Methotrexate may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Levorphanol Levorphanol The risk or severity of adverse effects can be increased when Fentanyl is combined with Levorphanol.
Primidone Primidone The risk or severity of adverse effects can be increased when Primidone is combined with Fentanyl.
Methsuximide Methsuximide The risk or severity of adverse effects can be increased when Fentanyl is combined with Methsuximide.
Diethylpropion Diethylpropion Diethylpropion may increase the analgesic activities of Fentanyl.
Chlorpromazine Chlorpromazine The risk or severity of adverse effects can be increased when Chlorpromazine is combined with Fentanyl.
Diazepam Diazepam The metabolism of Fentanyl can be decreased when combined with Diazepam.
Oxazepam Oxazepam The risk or severity of adverse effects can be increased when Fentanyl is combined with Oxazepam.
Flurazepam Flurazepam The risk or severity of adverse effects can be increased when Fentanyl is combined with Flurazepam.
Clorazepate Clorazepate The risk or severity of adverse effects can be increased when Fentanyl is combined with Clorazepic acid.
Lorazepam Lorazepam The risk or severity of adverse effects can be increased when Fentanyl is combined with Lorazepam.
Phenoxybenzamine Phenoxybenzamine The risk or severity of hypertension can be increased when Fentanyl is combined with Phenoxybenzamine.
Carmustine Carmustine Carmustine may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Amantadine Amantadine The risk or severity of adverse effects can be increased when Amantadine is combined with Fentanyl.
Codeine Codeine The risk or severity of adverse effects can be increased when Codeine is combined with Fentanyl.
Meprobamate Meprobamate The risk or severity of adverse effects can be increased when Meprobamate is combined with Fentanyl.
Chlordiazepoxide Chlordiazepoxide The risk or severity of adverse effects can be increased when Fentanyl is combined with Chlordiazepoxide.
Bromocriptine Bromocriptine The metabolism of Fentanyl can be decreased when combined with Bromocriptine.
Metaproterenol Metaproterenol The risk or severity of hypertension can be increased when Fentanyl is combined with Orciprenaline.
Tranylcypromine Tranylcypromine The metabolism of Fentanyl can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine The metabolism of Fentanyl can be decreased when combined with Phenelzine.
Procarbazine Procarbazine The risk or severity of adverse effects can be increased when Procarbazine is combined with Fentanyl.
Ergoloid Mesylates Ergoloid Mesylates The risk or severity of adverse effects can be increased when Fentanyl is combined with Ergoloid mesylate.
Tetracycline Tetracycline The metabolism of Fentanyl can be decreased when combined with Tetracycline.
Minocycline Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Fentanyl.
Prochlorperazine Prochlorperazine The risk or severity of adverse effects can be increased when Prochlorperazine is combined with Fentanyl.
Thioridazine Thioridazine The risk or severity of hypotension and CNS depression can be increased when Thioridazine is combined with Fentanyl.
Trifluoperazine Trifluoperazine The risk or severity of hypotension and CNS depression can be increased when Trifluoperazine is combined with Fentanyl.
Bleomycin Bleomycin Bleomycin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Dapsone Dapsone The metabolism of Fentanyl can be decreased when combined with Dapsone.
Sulfadiazine Sulfadiazine Sulfadiazine may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Oxycodone Oxycodone The risk or severity of adverse effects can be increased when Oxycodone is combined with Fentanyl.
Methadone Methadone The metabolism of Fentanyl can be decreased when combined with Methadone.
Oxybutynin Oxybutynin The metabolism of Fentanyl can be decreased when combined with Oxybutynin.
Benztropine Benztropine The risk or severity of adverse effects can be increased when Benzatropine is combined with Fentanyl.
Maprotiline Maprotiline The risk or severity of adverse effects can be increased when Maprotiline is combined with Fentanyl.
Ibuprofen Ibuprofen Fentanyl may decrease the excretion rate of Ibuprofen which could result in a higher serum level.
Trihexyphenidyl Trihexyphenidyl The risk or severity of adverse effects can be increased when Fentanyl is combined with Trihexyphenidyl.
Orphenadrine Orphenadrine The metabolism of Fentanyl can be decreased when combined with Orphenadrine.
Perphenazine Perphenazine The risk or severity of adverse effects can be increased when Fentanyl is combined with Perphenazine.
Azathioprine Azathioprine Fentanyl may decrease the excretion rate of Azathioprine which could result in a higher serum level.
Fluphenazine Fluphenazine The risk or severity of hypotension and CNS depression can be increased when Fluphenazine is combined with Fentanyl.
Phentermine Phentermine Phentermine may increase the analgesic activities of Fentanyl.
Methylphenidate Methylphenidate The risk or severity of hypertension can be increased when Methylphenidate is combined with Fentanyl.
Amoxapine Amoxapine The risk or severity of adverse effects can be increased when Amoxapine is combined with Fentanyl.
Sulfasalazine Sulfasalazine Sulfasalazine may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Hydrocortisone Hydrocortisone The metabolism of Fentanyl can be decreased when combined with Hydrocortisone.
Doxorubicin Doxorubicin The metabolism of Fentanyl can be decreased when combined with Doxorubicin.
Phenazopyridine Phenazopyridine Phenazopyridine may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Carbamazepine Carbamazepine The metabolism of Fentanyl can be decreased when combined with Carbamazepine.
Molindone Molindone The risk or severity of adverse effects can be increased when Fentanyl is combined with Molindone.
Methyldopa Methyldopa Fentanyl may decrease the antihypertensive activities of Methyldopa.
Clonidine Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Fentanyl.
Prazosin Prazosin Fentanyl may decrease the antihypertensive activities of Prazosin.
Hydralazine Hydralazine The metabolism of Fentanyl can be decreased when combined with Hydralazine.
Cimetidine Cimetidine The metabolism of Fentanyl can be decreased when combined with Cimetidine.
Gentamicin Injection Gentamicin Injection Gentamicin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Warfarin Warfarin Fentanyl may decrease the excretion rate of Warfarin which could result in a higher serum level.
Clonazepam Clonazepam The risk or severity of adverse effects can be increased when Fentanyl is combined with Clonazepam.
Loperamide Loperamide The metabolism of Fentanyl can be decreased when combined with Loperamide.
Promethazine Promethazine The risk or severity of adverse effects can be increased when Promethazine is combined with Fentanyl.
Meclofenamate Meclofenamate Fentanyl may decrease the excretion rate of Meclofenamic acid which could result in a higher serum level.
Daunorubicin Daunorubicin The metabolism of Fentanyl can be decreased when combined with Daunorubicin.
Nitrofurantoin Nitrofurantoin Nitrofurantoin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Digoxin Digoxin Digoxin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Loxapine Loxapine The risk or severity of adverse effects can be increased when Loxapine is combined with Fentanyl.
Chloroquine Chloroquine The metabolism of Fentanyl can be decreased when combined with Chloroquine.
Quinine Quinine The metabolism of Fentanyl can be decreased when combined with Quinine.
Ethosuximide Ethosuximide The risk or severity of adverse effects can be increased when Ethosuximide is combined with Fentanyl.
Triamterene Triamterene Triamterene may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Lactulose Lactulose The therapeutic efficacy of Lactulose can be decreased when used in combination with Fentanyl.
Chlorothiazide Chlorothiazide The therapeutic efficacy of Chlorothiazide can be decreased when used in combination with Fentanyl.
Chlorthalidone Chlorthalidone The therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Fentanyl.
Metolazone Metolazone Fentanyl may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Isosorbide Isosorbide The therapeutic efficacy of Isosorbide can be decreased when used in combination with Fentanyl.
Clindamycin Injection Clindamycin Injection The metabolism of Clindamycin can be decreased when combined with Fentanyl.
Secobarbital Secobarbital The risk or severity of adverse effects can be increased when Secobarbital is combined with Fentanyl.
Desipramine Desipramine The metabolism of Fentanyl can be decreased when combined with Desipramine.
Amitriptyline Amitriptyline The risk or severity of adverse effects can be increased when Fentanyl is combined with Amitriptyline.
Imipramine Imipramine The risk or severity of adverse effects can be increased when Fentanyl is combined with Imipramine.
Probenecid Probenecid Fentanyl may decrease the excretion rate of Probenecid which could result in a higher serum level.
Quinidine Quinidine The metabolism of Fentanyl can be decreased when combined with Quinidine.
Procainamide Procainamide Fentanyl may decrease the excretion rate of Procainamide which could result in a higher serum level.
Isoniazid Isoniazid The metabolism of Fentanyl can be decreased when combined with Isoniazid.
Pyrazinamide Pyrazinamide Pyrazinamide may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Rifampin Rifampin The metabolism of Fentanyl can be increased when combined with Rifampicin.
Disopyramide Disopyramide The risk or severity of adverse effects can be increased when Disopyramide is combined with Fentanyl.
Valproic Acid Valproic Acid The metabolism of Fentanyl can be decreased when combined with Valproic acid.
Tamoxifen Tamoxifen The metabolism of Fentanyl can be decreased when combined with Tamoxifen.
Butabarbital Butabarbital The risk or severity of adverse effects can be increased when Butabarbital is combined with Fentanyl.
Liothyronine Liothyronine Liothyronine may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Methimazole Methimazole The metabolism of Fentanyl can be decreased when combined with Methimazole.
Chlorpropamide Chlorpropamide Chlorpropamide may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Tolbutamide Tolbutamide Fentanyl may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Tolazamide Tolazamide Fentanyl may decrease the excretion rate of Tolazamide which could result in a higher serum level.
Dextromethorphan Dextromethorphan The risk or severity of adverse effects can be increased when Dextromethorphan is combined with Fentanyl.
Cyclobenzaprine Cyclobenzaprine The risk or severity of CNS depression can be increased when Fentanyl is combined with Cyclobenzaprine.
Baclofen Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Fentanyl.
Doxylamine Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Fentanyl.
Cyproheptadine Cyproheptadine The risk or severity of adverse effects can be increased when Cyproheptadine is combined with Fentanyl.
Clemastine Clemastine The risk or severity of adverse effects can be increased when Clemastine is combined with Fentanyl.
Chlorpheniramine Chlorpheniramine The risk or severity of adverse effects can be increased when Fentanyl is combined with Chlorpheniramine.
Brompheniramine Brompheniramine The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Fentanyl.
Meclizine Meclizine The risk or severity of adverse effects can be increased when Meclizine is combined with Fentanyl.
Ethambutol Ethambutol Ethambutol may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Methyclothiazide Methyclothiazide The therapeutic efficacy of Methyclothiazide can be decreased when used in combination with Fentanyl.
Hydrochlorothiazide Hydrochlorothiazide Fentanyl may decrease the excretion rate of Hydrochlorothiazide which could result in a higher serum level.
Dantrolene Dantrolene The risk or severity of adverse effects can be increased when Fentanyl is combined with Dantrolene.
Chlorzoxazone Chlorzoxazone The risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Fentanyl.
Carisoprodol Carisoprodol The risk or severity of adverse effects can be increased when Carisoprodol is combined with Fentanyl.
Methocarbamol Methocarbamol The risk or severity of adverse effects can be increased when Methocarbamol is combined with Fentanyl.
Pyridoxine Pyridoxine Pyridoxine may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Folic Acid Folic Acid Folic acid may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Danazol Danazol The metabolism of Fentanyl can be decreased when combined with Danazol.
Disulfiram Disulfiram The metabolism of Disulfiram can be decreased when combined with Fentanyl.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) Fentanyl may decrease the antihypertensive activities of Propranolol.
Minoxidil Minoxidil Fentanyl may decrease the antihypertensive activities of Minoxidil.
Pseudoephedrine Pseudoephedrine The therapeutic efficacy of Fentanyl can be decreased when used in combination with Pseudoephedrine.
Nortriptyline Nortriptyline The risk or severity of adverse effects can be increased when Nortriptyline is combined with Fentanyl.
Spironolactone Spironolactone Spironolactone may increase the excretion rate of Fentanyl which could result in a lower serum level and potentially a reduction in efficacy.
Amphotericin B Injection Amphotericin B Injection The metabolism of Fentanyl can be decreased when combined with Amphotericin B.
Phytonadione Phytonadione Fentanyl may decrease the excretion rate of Phylloquinone which could result in a higher serum level.
Amikacin Injection Amikacin Injection Amikacin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Nadolol Nadolol Fentanyl may decrease the antihypertensive activities of Nadolol.
Butorphanol Injection Butorphanol Injection The therapeutic efficacy of Fentanyl can be decreased when used in combination with Butorphanol.
Nalbuphine Injection Nalbuphine Injection The therapeutic efficacy of Nalbuphine can be decreased when used in combination with Fentanyl.
Allopurinol Allopurinol Allopurinol may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Trimethobenzamide Trimethobenzamide The risk or severity of adverse effects can be increased when Trimethobenzamide is combined with Fentanyl.
Flavoxate Flavoxate The risk or severity of adverse effects can be increased when Flavoxate is combined with Fentanyl.
Colchicine Colchicine The metabolism of Fentanyl can be decreased when combined with Colchicine.
Cefaclor Cefaclor Cefaclor may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Cefadroxil Cefadroxil Cefadroxil may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Cefazolin Injection Cefazolin Injection Cefazolin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Cephalexin Cephalexin Cephalexin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Cefoxitin Injection Cefoxitin Injection Cefoxitin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Dacarbazine Dacarbazine Fentanyl may decrease the excretion rate of Dacarbazine which could result in a higher serum level.
Acetazolamide Acetazolamide The metabolism of Fentanyl can be decreased when combined with Acetazolamide.
Cefotaxime Injection Cefotaxime Injection Cefotaxime may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Calcitonin Salmon Injection Calcitonin Salmon Injection Salmon calcitonin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Ketoconazole Ketoconazole The metabolism of Fentanyl can be decreased when combined with Ketoconazole.
Pyrantel Pyrantel The risk or severity of adverse effects can be increased when Fentanyl is combined with Pyrantel.
Vincristine Injection Vincristine Injection The metabolism of Fentanyl can be decreased when combined with Vincristine.
Captopril Captopril Fentanyl may decrease the antihypertensive activities of Captopril.
Isoxsuprine Isoxsuprine The risk or severity of hypertension can be increased when Fentanyl is combined with Isoxsuprine.
Vinblastine Vinblastine The metabolism of Fentanyl can be decreased when combined with Vinblastine.
Ethacrynic Acid Ethacrynic Acid Etacrynic acid may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Colistimethate Injection Colistimethate Injection Colistimethate may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Metoprolol Metoprolol Fentanyl may decrease the antihypertensive activities of Metoprolol.
Hydroxyzine Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Fentanyl.
Thiothixene Thiothixene The risk or severity of adverse effects can be increased when Fentanyl is combined with Thiothixene.
Aspirin Aspirin Fentanyl may decrease the excretion rate of Acetylsalicylic acid which could result in a higher serum level.
Salsalate Salsalate Fentanyl may decrease the excretion rate of Salsalate which could result in a higher serum level.
Alprazolam Alprazolam The risk or severity of adverse effects can be increased when Fentanyl is combined with Alprazolam.
Temazepam Temazepam The risk or severity of adverse effects can be increased when Fentanyl is combined with Temazepam.
Triazolam Triazolam The risk or severity of adverse effects can be increased when Fentanyl is combined with Triazolam.
Dicyclomine Dicyclomine The risk or severity of adverse effects can be increased when Dicyclomine is combined with Fentanyl.
Hyoscyamine Hyoscyamine The risk or severity of adverse effects can be increased when Fentanyl is combined with Hyoscyamine.
Propantheline Propantheline The risk or severity of adverse effects can be increased when Propantheline is combined with Fentanyl.
Trimethoprim Trimethoprim Trimethoprim may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Diltiazem Diltiazem The metabolism of Fentanyl can be decreased when combined with Diltiazem.
Nifedipine Nifedipine Fentanyl may increase the bradycardic activities of Nifedipine.
Timolol Timolol Fentanyl may decrease the antihypertensive activities of Timolol.
Verapamil Verapamil The metabolism of Fentanyl can be decreased when combined with Verapamil.
Atenolol Atenolol Fentanyl may decrease the antihypertensive activities of Atenolol.
Pindolol Pindolol The risk or severity of adverse effects can be increased when Fentanyl is combined with Pindolol.
Cisplatin Injection Cisplatin Injection Fentanyl may decrease the excretion rate of Cisplatin which could result in a higher serum level.
Diflunisal Diflunisal Fentanyl may decrease the excretion rate of Diflunisal which could result in a higher serum level.
Piroxicam Piroxicam Piroxicam may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Bumetanide Bumetanide Bumetanide may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Etoposide Etoposide The metabolism of Fentanyl can be decreased when combined with Etoposide.
Glyburide Glyburide The metabolism of Fentanyl can be decreased when combined with Glyburide.
Glipizide Glipizide Fentanyl may decrease the excretion rate of Glipizide which could result in a higher serum level.
Indapamide Indapamide Fentanyl may increase the excretion rate of Indapamide which could result in a lower serum level and potentially a reduction in efficacy.
Amoxicillin Amoxicillin Fentanyl may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Oxacillin Injection Oxacillin Injection Oxacillin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Pentoxifylline Pentoxifylline Pentoxifylline may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Pentamidine Injection Pentamidine Injection Pentamidine may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Ceftriaxone Injection Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Labetalol Labetalol Fentanyl may decrease the antihypertensive activities of Labetalol.
Auranofin Auranofin Fentanyl may decrease the excretion rate of Auranofin which could result in a higher serum level.
Leuprolide Injection Leuprolide Injection Leuprolide may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Gemfibrozil Gemfibrozil Fentanyl may decrease the excretion rate of Gemfibrozil which could result in a higher serum level.
Guanabenz Guanabenz The risk or severity of hypertension can be increased when Guanabenz is combined with Fentanyl.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Ceftazidime Injection Ceftazidime Injection Ceftazidime may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Ketoprofen Ketoprofen Fentanyl may decrease the excretion rate of Ketoprofen which could result in a higher serum level.
Cefotetan Injection Cefotetan Injection Cefotetan may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Pimozide Pimozide The metabolism of Fentanyl can be decreased when combined with Pimozide.
Enalapril Enalapril Fentanyl may decrease the antihypertensive activities of Enalapril.
Flurbiprofen Flurbiprofen Flurbiprofen may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Amiodarone Amiodarone The risk or severity of adverse effects can be increased when Amiodarone is combined with Fentanyl.
Aztreonam Injection Aztreonam Injection Aztreonam may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Buspirone Buspirone The risk or severity of serotonin syndrome can be increased when Buspirone is combined with Fentanyl.
Lovastatin Lovastatin The metabolism of Fentanyl can be decreased when combined with Lovastatin.
Ciprofloxacin Ciprofloxacin The metabolism of Fentanyl can be decreased when combined with Ciprofloxacin.
Mesalamine Mesalamine Mesalazine may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Diclofenac Diclofenac Diclofenac may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Fluoxetine Fluoxetine The risk or severity of serotonin syndrome can be increased when Fentanyl is combined with Fluoxetine.
Nimodipine Nimodipine Fentanyl may decrease the antihypertensive activities of Nimodipine.
Clozapine Clozapine The metabolism of Fentanyl can be decreased when combined with Clozapine.
Estazolam Estazolam The risk or severity of adverse effects can be increased when Fentanyl is combined with Estazolam.
Didanosine Didanosine Fentanyl may decrease the excretion rate of Didanosine which could result in a higher serum level.
Pentostatin Injection Pentostatin Injection Pentostatin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Clarithromycin Clarithromycin The metabolism of Fentanyl can be decreased when combined with Clarithromycin.
Benazepril Benazepril Fentanyl may decrease the antihypertensive activities of Benazepril.
Etodolac Etodolac Etodolac may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Felodipine Felodipine The metabolism of Fentanyl can be decreased when combined with Felodipine.
Fosinopril Fosinopril Fentanyl may decrease the antihypertensive activities of Fosinopril.
Nabumetone Nabumetone Nabumetone may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Quinapril Quinapril Fentanyl may decrease the antihypertensive activities of Quinapril.
Ramipril Ramipril Fentanyl may decrease the antihypertensive activities of Ramipril.
Simvastatin Simvastatin The metabolism of Fentanyl can be decreased when combined with Simvastatin.
Amlodipine Amlodipine Fentanyl may decrease the antihypertensive activities of Amlodipine.
Teniposide Injection Teniposide Injection The metabolism of Fentanyl can be decreased when combined with Teniposide.
Itraconazole Itraconazole The metabolism of Fentanyl can be decreased when combined with Itraconazole.
Lisinopril Lisinopril Fentanyl may decrease the antihypertensive activities of Lisinopril.
Oxaprozin Oxaprozin Fentanyl may decrease the excretion rate of Oxaprozin which could result in a higher serum level.
Sotalol Sotalol Sotalol may increase the bradycardic activities of Fentanyl.
Bisoprolol Bisoprolol Fentanyl may decrease the antihypertensive activities of Bisoprolol.
Zolpidem Zolpidem Fentanyl may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Doxazosin Doxazosin Fentanyl may decrease the antihypertensive activities of Doxazosin.
Terazosin Terazosin Fentanyl may decrease the antihypertensive activities of Terazosin.
Isradipine Isradipine The metabolism of Fentanyl can be decreased when combined with Isradipine.
Omeprazole Omeprazole The metabolism of Fentanyl can be decreased when combined with Omeprazole.
Cisapride Cisapride The risk or severity of adverse effects can be increased when Cisapride is combined with Fentanyl.
Gabapentin Gabapentin The risk or severity of adverse effects can be increased when Fentanyl is combined with Gabapentin.
Fluvastatin Fluvastatin The metabolism of Fentanyl can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine The risk or severity of adverse effects can be increased when Venlafaxine is combined with Fentanyl.
Fluvoxamine Fluvoxamine The metabolism of Fentanyl can be decreased when combined with Fluvoxamine.
Nefazodone Nefazodone The metabolism of Fentanyl can be decreased when combined with Nefazodone.
Lamotrigine Lamotrigine The risk or severity of adverse effects can be increased when Lamotrigine is combined with Fentanyl.
Losartan Losartan The metabolism of Fentanyl can be decreased when combined with Losartan.
Valacyclovir Valacyclovir Valaciclovir may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Tramadol Tramadol The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Fentanyl.
Carboplatin Injection Carboplatin Injection Carboplatin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Moexipril Moexipril Fentanyl may decrease the antihypertensive activities of Moexipril.
Lansoprazole Lansoprazole The metabolism of Fentanyl can be decreased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The metabolism of Fentanyl can be decreased when combined with Ifosfamide.
Nicardipine Nicardipine The metabolism of Fentanyl can be decreased when combined with Nicardipine.
Bupropion Bupropion The risk or severity of seizure can be increased when Fentanyl is combined with Bupropion.
Ticlopidine Ticlopidine Ticlopidine may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Saquinavir Saquinavir The metabolism of Fentanyl can be decreased when combined with Saquinavir.
Metformin Metformin Metformin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Nisoldipine Nisoldipine Fentanyl may decrease the antihypertensive activities of Nisoldipine.
Lamivudine Lamivudine Lamivudine may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Riluzole Riluzole The risk or severity of adverse effects can be increased when Riluzole is combined with Fentanyl.
Acarbose Acarbose Acarbose may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Gemcitabine Injection Gemcitabine Injection Gemcitabine may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Indinavir Indinavir The metabolism of Fentanyl can be decreased when combined with Indinavir.
Ritonavir Ritonavir The metabolism of Fentanyl can be decreased when combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Fentanyl can be decreased when combined with Docetaxel.
Cidofovir Injection Cidofovir Injection Cidofovir may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Meropenem Injection Meropenem Injection Meropenem may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Clomipramine Clomipramine The risk or severity of adverse effects can be increased when Fentanyl is combined with Clomipramine.
Zafirlukast Zafirlukast The metabolism of Fentanyl can be decreased when combined with Zafirlukast.
Fosfomycin Fosfomycin Fentanyl may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Mirtazapine Mirtazapine The metabolism of Mirtazapine can be decreased when combined with Fentanyl.
Trandolapril Trandolapril Fentanyl may decrease the antihypertensive activities of Trandolapril.
Topiramate Topiramate The risk or severity of adverse effects can be increased when Topiramate is combined with Fentanyl.
Valsartan Valsartan Fentanyl may decrease the antihypertensive activities of Valsartan.
Pramipexole Pramipexole Fentanyl may increase the sedative activities of Pramipexole.
Donepezil Donepezil The risk or severity of adverse effects can be increased when Fentanyl is combined with Donepezil.
Nelfinavir Nelfinavir The metabolism of Fentanyl can be decreased when combined with Nelfinavir.
Carvedilol Carvedilol Fentanyl may decrease the antihypertensive activities of Carvedilol.
Nilutamide Nilutamide Nilutamide may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Flutamide Flutamide The metabolism of Fentanyl can be decreased when combined with Flutamide.
Selegiline Selegiline The risk or severity of adverse effects can be increased when Selegiline is combined with Fentanyl.
Bicalutamide Bicalutamide The metabolism of Fentanyl can be decreased when combined with Bicalutamide.
Sertraline Sertraline The risk or severity of serotonin syndrome can be increased when Fentanyl is combined with Sertraline.
Propafenone Propafenone Fentanyl may increase the bradycardic activities of Propafenone.
Raloxifene Raloxifene The metabolism of Fentanyl can be decreased when combined with Raloxifene.
Irbesartan Irbesartan The metabolism of Fentanyl can be decreased when combined with Irbesartan.
Tamsulosin Tamsulosin Tamsulosin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Ropinirole Ropinirole Fentanyl may increase the sedative activities of Ropinirole.
Finasteride Finasteride The metabolism of Finasteride can be decreased when combined with Fentanyl.
Quetiapine Quetiapine The risk or severity of adverse effects can be increased when Quetiapine is combined with Fentanyl.
Cefepime Injection Cefepime Injection Cefepime may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Cefprozil Cefprozil Cefprozil may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Cefpodoxime Cefpodoxime Cefpodoxime may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Cetirizine Cetirizine The risk or severity of adverse effects can be increased when Cetirizine is combined with Fentanyl.
Paroxetine Paroxetine The metabolism of Fentanyl can be decreased when combined with Paroxetine.
Tolcapone Tolcapone The risk or severity of adverse effects can be increased when Tolcapone is combined with Fentanyl.
Citalopram Citalopram The metabolism of Fentanyl can be decreased when combined with Citalopram.
Capecitabine Capecitabine Fentanyl may decrease the excretion rate of Capecitabine which could result in a higher serum level.
Efavirenz Efavirenz The metabolism of Fentanyl can be decreased when combined with Efavirenz.
Abacavir Abacavir Fentanyl may decrease the excretion rate of Abacavir which could result in a higher serum level.
Sildenafil Sildenafil The metabolism of Fentanyl can be decreased when combined with Sildenafil.
Celecoxib Celecoxib Celecoxib may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Rosiglitazone Rosiglitazone Rosiglitazone may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Tolterodine Tolterodine The risk or severity of adverse effects can be increased when Tolterodine is combined with Fentanyl.
Thalidomide Thalidomide Fentanyl may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Oseltamivir Oseltamivir Oseltamivir may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Balsalazide Balsalazide Fentanyl may decrease the excretion rate of Balsalazide which could result in a higher serum level.
Nateglinide Nateglinide The metabolism of Fentanyl can be decreased when combined with Nateglinide.
Galantamine Galantamine Galantamine may increase the bradycardic activities of Fentanyl.
Levetiracetam Levetiracetam The risk or severity of adverse effects can be increased when Fentanyl is combined with Levetiracetam.
Rabeprazole Rabeprazole The metabolism of Fentanyl can be decreased when combined with Rabeprazole.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists