Fentanyl

Fentanyl is used to treat breakthrough pain (sudden episodes of pain that occur despite round the clock treatment with pain medication) in cancer patients at least 18 years of age (or at least 16 years of age if using Actiq brand lozenges) who are taking regularly scheduled doses of another narcotic (opiate) pain medication, and who are tolerant (used to the effects of the medication) to narcotic pain medications. Fentanyl is in a class of medications called narcotic (opiate) analgesics. It works by changing the way the brain and nervous system respond to pain.

Fentanyl comes as a lozenge on a handle (Actiq), a sublingual (underneath the tongue) tablet (Abstral), a film (Onsolis), and a buccal (between the gum and cheek) tablet (Fentora) to dissolve in the mouth. Fentanyl is used as needed to treat breakthrough pain but not more often than four times a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.

Your doctor will probably start you on a low dose of fentanyl and gradually increase your dose until you find the dose that will relieve your breakthrough pain. If you still have pain 30 minutes after using fentanyl films (Onsolis), your doctor may tell you to use another pain medication to relieve that pain, and may increase your dose of fentanyl films (Onsolis) to treat your next episode of pain . Talk to your doctor about how well the medication is working and whether you are experiencing any side effects so that your doctor can decide whether your dose should be adjusted.

Do not use fentanyl more than four times a day. Call your doctor if you experience more than four episodes of breakthrough pain per day. Your doctor may need to adjust the dose of your other pain medication(s) to better control your pain.

Swallow the buccal tablet whole; do not split, chew, or crush. Also do not chew or bite the lozenge on a handle; only suck on this medication as directed.

Do not stop using fentanyl without talking to your doctor. Your doctor may decrease your dose gradually. If you suddenly stop using fentanyl, you may experience unpleasant withdrawal symptoms.

To use fentanyl lozenges (Actiq), follow these steps:

1. Check the blister package and the handle of the lozenge to make sure the lozenge contains the dose of medication you have been prescribed.

2. Use scissors to cut open the blister package and remove the lozenge. Do not open the blister package until you are ready to use the medication.

3. Place the lozenge in your mouth, between your cheek and gum. Actively suck on the lozenge, but do not chew, crush, or bite it. Move the lozenge around in your mouth, from one side to the other, using the handle. Twirl the handle often.

4. Do not eat or drink anything while the lozenge is in your mouth.

5. Finish the lozenge in about 15 minutes.

6. If you begin to feel dizzy, very sleepy, or nauseated before you have finished the lozenge, remove it from your mouth. Dispose of it immediately as described below or put it in the temporary storage bottle for later disposal.

7. If you finish the entire lozenge, throw the handle away in a garbage can that is out of the reach of children. If you did not finish the entire lozenge, hold the handle under hot running water to dissolve all the medication, and then throw the handle away in a garbage can that is out of the reach of children and pets.

To use fentanyl buccal tablets (Fentora), follow these steps:

1. Separate one blister unit from the blister card by tearing along the perforations. Peel back the foil to open the blister unit. Do not try to push the tablet through the foil. Do not open the blister unit until you are ready to use the tablet.

2. Place the tablet in your mouth above one of your upper back teeth between your cheek and your gum.

3. Leave the tablet in place until it dissolves completely. You may notice a gentle bubbling feeling between your cheek and gum as the tablet dissolves. It may take 14 to 25 minutes for the tablet to dissolve. Do not split, chew, bite, or suck the tablet.

4. If any of the tablet is left in your mouth after 30 minutes, swallow it with a drink of water.

5. If you begin to feel dizzy, very sleepy, or nauseated before the tablet dissolves, rinse your mouth with water and spit the remaining pieces of tablet into the sink or toilet. Flush the toilet or rinse the sink to wash away the tablet pieces.

To use fentanyl sublingual tablets (Abstral), follow these steps:

1. Take a sip of water to moisten your mouth if it is dry. Spit out or swallow the water. Make sure your hands are dry before handling the tablet.

2. Separate one blister unit from the blister card by tearing along the perforations. Peel back the foil to open the blister unit. Do not try to push the tablet through the foil. Do not open the blister unit until you are ready to use the tablet.

3. Place the tablet under your tongue as far back as you can. If more than 1 tablet is needed for your dose, spread them around on the floor of your mouth under your tongue.

4. Leave the tablet in place until it dissolves completely. Do not suck, chew, or swallow the tablet.

5. Do not eat or drink anything until the tablet is completely dissolved and you no longer feel it in your mouth.

To use fentanyl films (Onsolis), follow these steps:

1. Use scissors to cut along the arrows of the foil package to open it. Separate the layers of the foil package and remove the film. Do not open the foil package until you are ready to use the medication. Do not cut or tear the film.

2. Use your tongue to wet the inside of your cheek, or if needed, rinse your mouth with water to wet the area where you will place the film.

3. Hold the film on a clean, dry finger, with the pink side facing up. Place the film in your mouth, with the pink side against the inside of your moistened cheek. With your finger, press the film against your cheek for 5 seconds. Then remove your finger and the film will stick to the inside of your cheek. If more than one film is needed for your dose, do not put the films on top of each other. You may place the films on either side of your mouth.

4. Leave the film in place until it dissolves completely. The film will release a minty flavor as it dissolves. It may take 15 to 30 minutes for the film to dissolve. Do not chew or swallow the film. Do not touch or move the film while it dissolves.

5. You may drink liquids after 5 minutes, but do not eat anything until the film dissolves completely.

This medication should not be prescribed for other uses; ask your doctor or pharmacist for more information.

Before using fentanyl,

• tell your doctor and pharmacist if you are allergic to fentanyl patches, injection, nasal spray, tablets, lozenges, or films; any other medications; or any of the ingredients in fentanyl tablets, lozenges, or films. Ask your pharmacist or check the Medication Guide for a list of the ingredients.

• tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following medications: antihistamines; barbiturates such as phenobarbital; buprenorphine (Buprenex, Subutex, in Suboxone); butorphanol (Stadol); carbamazepine (Carbatrol, Epitol, Tegretol); efavirenz (Sustiva, in Atripla); modafinil (Provigil); nalbuphine (Nubain); naloxone (Evzio, Narcan); nevirapine (Viramune); oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos); oxcarbazepine (Trileptal); pentazocine (Talwin); phenytoin (Dilantin, Phenytek); pioglitazone (Actos, in Actoplus Met, in Duetact); rifabutin (Mycobutin); and rifampin (Rifadin, Rimactane, in Rifamate, in Rifater). Also tell your doctor or pharmacist if you are taking any of the following medications or if you have stopped taking them within the past two weeks: monoamine oxidase (MAO) inhibitors including isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

• tell your doctor what herbal products you are taking, especially St. John's wort.

• tell your doctor if you or anyone in your family drinks or has ever drunk large amounts of alcohol or uses or has ever used street drugs or excessive amounts of prescription medications. Also tell your doctor if you have or have ever had a head injury, a brain tumor, a stroke, or any other condition that caused high pressure inside your skull; seizures; slowed heartbeat or other heart problems; low blood pressure; mental problems such as depression, schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions), or hallucinations (seeing things or hearing voices that do not exist); breathing problems such as asthma and chronic obstructive pulmonary disease (COPD; a group of lung diseases that includes chronic bronchitis and emphysema); or kidney or liver disease.

• tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while using fentanyl, call your doctor.

• you should know that this medication may decrease fertility in men and women. Talk to your doctor about the risks of using fentanyl.

• if you are having surgery, including dental surgery, tell the doctor or dentist that you are using fentanyl.

• you should know that fentanyl may make you drowsy or dizzy. Do not drive a car or operate machinery until you know how this medication affects you.

• you should know that fentanyl may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. This is more common when you first start using fentanyl. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.

• if you have diabetes, you should know that each fentanyl lozenge (Actiq) contains about 2 grams of sugar.

• if you will be using the lozenges (Actiq), talk to your dentist about the best way to care for your teeth during your treatment. The lozenges contain sugar and may cause tooth decay and other dental problems.

• you should know that fentanyl may cause constipation. Talk to your doctor about changing your diet and using other medications to treat or prevent constipation.

Do not eat grapefruit or drink grapefruit juice while using this medication.

This medication is usually used as needed according to directions.

• Fentanyl may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • drowsiness

  • stomach pain

  • gas

  • heartburn

  • weight loss

  • difficulty urinating

  • changes in vision

  • anxiety

  • depression

  • unusual thinking

  • unusual dreams

  • difficulty falling asleep or staying asleep

  • dry mouth

  • sudden reddening of the face, neck, or upper chest

  • uncontrollable shaking of a part of the body

  • back pain

  • chest pain

  • pain, sores, or irritation in the mouth in the area where you placed the medication

  • swelling of the hands, arms, feet, ankles, or lower legs

• Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

  • changes in heartbeat

  • agitation, hallucinations (seeing things or hearing voices that do not exist), fever, sweating, confusion, fast heartbeat, shivering, severe muscle stiffness or twitching, loss of coordination, nausea, vomiting, or diarrhea

  • nausea, vomiting, loss of appetite, weakness, or dizziness

  • inability to get or keep an erection

  • irregular menstruation

  • decreased sexual desire

  • seizures

  • hives

  • rash

  • itching

• If you experience any of these symptoms, stop using fentanyl and call your doctor immediately or get emergency medical treatment:

  • slow, shallow breathing

  • decreased urge to breathe

  • difficulty breathing or swallowing

  • extreme drowsiness

  • dizziness

  • confusion

  • fainting

• Fentanyl may cause other side effects. Call your doctor if you have any unusual problems while using this medication.

• If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the packaging it came in, tightly closed, and out of reach of children. Store fentanyl in a safe place so that no one else can use it accidentally or on purpose. Use the child-resistant locks and other supplies provided by the manufacturer to keep children away from the lozenges. Keep track of how much fentanyl is left so you will know if any is missing. Store fentanyl at room temperature and away from excess heat and moisture (not in the bathroom). Do not freeze fentanyl.

You must immediately dispose of any medication that is outdated or no longer needed through a medicine take-back program.. If you do not have a take-back program nearby or one that you can access promptly, then flush the fentanyl down the toilet so that others will not take it. Dispose of unneeded lozenges by removing each lozenge from the blister package, holding the lozenge over the toilet, and cutting off the medicine end with wire cutters so that it falls into the toilet. Throw away the remaining handles in a place that is out of the reach of children and pets, and flush the toilet twice when it contains up to five lozenges. Dispose of unneeded tablets or films by removing them from the packaging and flushing them down the toilet. Throw the remaining fentanyl packaging or cartons into a trash container; do not flush these items down the toilet. Call your pharmacist or the manufacturer if you have questions or need help disposing of unneeded medication.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, remove the fentanyl from the victim's mouth and call local emergency services at 911.

While using fentanyl, you should talk to your doctor about having a rescue medication called naloxone readily available (e.g., home, office). Naloxone is used to reverse the life-threatening effects of an overdose. It works by blocking the effects of opiates to relieve dangerous symptoms caused by high levels of opiates in the blood. Your doctor may also prescribe you naloxone if you are living in a household where there are small children or someone who has abused street or prescription drugs. You should make sure that you and your family members, caregivers, or the people who spend time with you know how to tell recognize an overdose, how to use naloxone, and what to do until emergency medical help arrives. Your doctor or pharmacist will show you and your family members how to use the medication. Ask your pharmacist for the instructions or visit the manufacturer's website to get the instructions. If symptoms of an overdose occur, a friend or family member should give the first dose of naloxone, call 911 immediately, and stay with you and watch you closely until emergency medical help arrives. Your symptoms may return within a few minutes after you receive naloxone. If your symptoms return, the person should give you another dose of naloxone. Additional doses may be given every 2 to 3 minutes, if symptoms return before medical help arrives.

Symptoms of overdose may include the following:

• drowsiness or sleepiness

• dizziness

• confusion

• slow, shallow breathing or stopped breathing

• difficulty breathing

• smaller pupils (black circles in the middle of the eyes)

• unable to respond or wake up

Keep all appointments with your doctor.

Do not let anyone else use your medication, even if he or she has the same symptoms that you have. Selling or giving away this medication may cause severe harm or death to others and is against the law.

This prescription is not refillable. Be sure to schedule appointments with your doctor on a regular basis so that you do not run out of medication.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug	Interaction
Delavirdine	Delavirdine The metabolism of Fentanyl can be decreased when combined with Delavirdine.
Nevirapine	Nevirapine The metabolism of Fentanyl can be decreased when combined with Nevirapine.
Atorvastatin	Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Fentanyl.
Dolasetron	Dolasetron The risk or severity of adverse effects can be increased when Dolasetron is combined with Fentanyl.
Bisacodyl	Bisacodyl The therapeutic efficacy of Bisacodyl can be decreased when used in combination with Fentanyl.
Candesartan	Candesartan Fentanyl may decrease the antihypertensive activities of Candesartan.
Cilostazol	Cilostazol The metabolism of Cilostazol can be decreased when combined with Fentanyl.
Clopidogrel	Clopidogrel Fentanyl can cause a decrease in the absorption of Clopidogrel resulting in a reduced serum concentration and potentially a decrease in efficacy.
Diphenoxylate	Diphenoxylate The risk or severity of adverse effects can be increased when Fentanyl is combined with Diphenoxylate.
Erythromycin and Sulfisoxazole	Erythromycin and Sulfisoxazole The metabolism of Fentanyl can be decreased when combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives)	Estrogen and Progestin (Oral Contraceptives) Conjugated estrogens may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Fenofibrate	Fenofibrate Fentanyl may decrease the excretion rate of Fenofibrate which could result in a higher serum level.
Guanfacine	Guanfacine The risk or severity of adverse effects can be increased when Fentanyl is combined with Guanfacine.
Magnesium Hydroxide	Magnesium Hydroxide The therapeutic efficacy of Magnesium hydroxide can be decreased when used in combination with Fentanyl.
Magnesium Oxide	Magnesium Oxide The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Fentanyl.
Methylergonovine	Methylergonovine The metabolism of Fentanyl can be decreased when combined with Methylergometrine.
Mycophenolate	Mycophenolate Fentanyl may decrease the excretion rate of Mycophenolic acid which could result in a higher serum level.
Naratriptan	Naratriptan The risk or severity of adverse effects can be increased when Fentanyl is combined with Naratriptan.
Olsalazine	Olsalazine Fentanyl may decrease the excretion rate of Olsalazine which could result in a higher serum level.
Paregoric	Paregoric The risk or severity of adverse effects can be increased when Morphine is combined with Fentanyl.
Penbutolol	Penbutolol Fentanyl may decrease the antihypertensive activities of Acebutolol.
Pentazocine	Pentazocine The therapeutic efficacy of Fentanyl can be decreased when used in combination with Pentazocine.
Polyethylene glycol-electrolyte solution (PEG-ES)	Polyethylene glycol-electrolyte solution (PEG-ES) The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Fentanyl.
Potassium	Potassium Fentanyl may increase the excretion rate of Potassium cation which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone	Prednisone Prednisone may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Psyllium	Psyllium The therapeutic efficacy of Plantago seed can be decreased when used in combination with Fentanyl.
Ranitidine	Ranitidine Fentanyl may decrease the excretion rate of Ranitidine which could result in a higher serum level.
Reserpine	Reserpine The risk or severity of adverse effects can be increased when Fentanyl is combined with Reserpine.
Rizatriptan	Rizatriptan The risk or severity of adverse effects can be increased when Fentanyl is combined with Rizatriptan.
Sumatriptan	Sumatriptan The risk or severity of adverse effects can be increased when Sumatriptan is combined with Fentanyl.
Tacrolimus	Tacrolimus The metabolism of Fentanyl can be decreased when combined with Tacrolimus.
Tizanidine	Tizanidine The risk or severity of adverse effects can be increased when Tizanidine is combined with Fentanyl.
Triamcinolone	Triamcinolone The metabolism of Fentanyl can be increased when combined with Triamcinolone.
Zolmitriptan	Zolmitriptan The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Fentanyl.
Ampicillin Injection	Ampicillin Injection Ampicillin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Doxycycline Injection	Doxycycline Injection Doxycycline may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Fluconazole Injection	Fluconazole Injection The metabolism of Fentanyl can be decreased when combined with Fluconazole.
Foscarnet Injection	Foscarnet Injection Foscarnet may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Hydromorphone Injection	Hydromorphone Injection The risk or severity of adverse effects can be increased when Hydromorphone is combined with Fentanyl.
Levofloxacin Injection	Levofloxacin Injection Fentanyl may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Meperidine Injection	Meperidine Injection The risk or severity of adverse effects can be increased when Meperidine is combined with Fentanyl.
Metoclopramide Injection	Metoclopramide Injection The therapeutic efficacy of Metoclopramide can be decreased when used in combination with Fentanyl.
Metronidazole Injection	Metronidazole Injection The metabolism of Fentanyl can be decreased when combined with Metronidazole.
Morphine Injection	Morphine Injection The risk or severity of adverse effects can be increased when Morphine is combined with Fentanyl.
Pamidronate Injection	Pamidronate Injection Pamidronic acid may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Vancomycin Injection	Vancomycin Injection Fentanyl may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Altretamine	Altretamine The risk or severity of adverse effects can be increased when Amphetamine is combined with Fentanyl.
Cefuroxime	Cefuroxime Cefuroxime may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Cyclosporine	Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Fentanyl.
Ondansetron	Ondansetron The risk or severity of adverse effects can be increased when Fentanyl is combined with Ondansetron.
Granisetron	Granisetron The risk or severity of adverse effects can be increased when Fentanyl is combined with Granisetron.
Torsemide	Torsemide The therapeutic efficacy of Torasemide can be decreased when used in combination with Fentanyl.
Olanzapine	Olanzapine The risk or severity of adverse effects can be increased when Fentanyl is combined with Olanzapine.
Alosetron	Alosetron The risk or severity of adverse effects can be increased when Fentanyl is combined with Alosetron.
Entacapone	Entacapone The risk or severity of adverse effects can be increased when Entacapone is combined with Fentanyl.
Eprosartan	Eprosartan Fentanyl may decrease the antihypertensive activities of Eprosartan.
Meloxicam	Meloxicam Fentanyl may decrease the excretion rate of Meloxicam which could result in a higher serum level.
Oxcarbazepine	Oxcarbazepine The metabolism of Fentanyl can be decreased when combined with Oxcarbazepine.
Pantoprazole	Pantoprazole Pantoprazole may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Telmisartan	Telmisartan Fentanyl may decrease the antihypertensive activities of Telmisartan.
Temozolomide	Temozolomide Fentanyl may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Zaleplon	Zaleplon The risk or severity of adverse effects can be increased when Fentanyl is combined with Zaleplon.
Anakinra	Anakinra The metabolism of Fentanyl can be increased when combined with Anakinra.
Desloratadine	Desloratadine The risk or severity of adverse effects can be increased when Fentanyl is combined with Desloratadine.
Linezolid	Linezolid The risk or severity of serotonin syndrome can be increased when Linezolid is combined with Fentanyl.
Rivastigmine	Rivastigmine Fentanyl may increase the bradycardic activities of Rivastigmine.
Trimipramine	Trimipramine The risk or severity of adverse effects can be increased when Trimipramine is combined with Fentanyl.
Etanercept Injection	Etanercept Injection The metabolism of Fentanyl can be increased when combined with Etanercept.
Glycopyrrolate	Glycopyrrolate The risk or severity of adverse effects can be increased when Fentanyl is combined with Glycopyrronium.
Modafinil	Modafinil The metabolism of Fentanyl can be increased when combined with Modafinil.
Perindopril	Perindopril Fentanyl may decrease the antihypertensive activities of Perindopril.
Tenofovir	Tenofovir Tenofovir may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Choline Magnesium Trisalicylate	Choline Magnesium Trisalicylate Fentanyl may decrease the excretion rate of Choline magnesium trisalicylate which could result in a higher serum level.
Sirolimus	Sirolimus The metabolism of Sirolimus can be decreased when combined with Fentanyl.
Dutasteride	Dutasteride The metabolism of Dutasteride can be decreased when combined with Fentanyl.
Epinephrine Injection	Epinephrine Injection The metabolism of Fentanyl can be decreased when combined with Epinephrine.
Eplerenone	Eplerenone Fentanyl may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Escitalopram	Escitalopram The risk or severity of serotonin syndrome can be increased when Escitalopram is combined with Fentanyl.
Olmesartan	Olmesartan Fentanyl may decrease the antihypertensive activities of Olmesartan.
Zonisamide	Zonisamide The risk or severity of adverse effects can be increased when Fentanyl is combined with Zonisamide.
Adalimumab Injection	Adalimumab Injection The metabolism of Fentanyl can be increased when combined with Adalimumab.
Aripiprazole	Aripiprazole The risk or severity of adverse effects can be increased when Aripiprazole is combined with Fentanyl.
Atomoxetine	Atomoxetine The risk or severity of adverse effects can be increased when Atomoxetine is combined with Fentanyl.
Dexmethylphenidate	Dexmethylphenidate The risk or severity of adverse effects can be increased when Fentanyl is combined with Dexmethylphenidate.
Atazanavir	Atazanavir The metabolism of Fentanyl can be decreased when combined with Atazanavir.
Almotriptan	Almotriptan The risk or severity of adverse effects can be increased when Fentanyl is combined with Almotriptan.
Eletriptan	Eletriptan The risk or severity of adverse effects can be increased when Eletriptan is combined with Fentanyl.
Mefloquine	Mefloquine The metabolism of Fentanyl can be decreased when combined with Mefloquine.
Polyethylene Glycol 3350	Polyethylene Glycol 3350 The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Fentanyl.
Rosuvastatin	Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Fentanyl.
Vardenafil	Vardenafil The metabolism of Vardenafil can be decreased when combined with Fentanyl.
Aprepitant	Aprepitant The metabolism of Fentanyl can be decreased when combined with Aprepitant.
Emtricitabine	Emtricitabine Fentanyl may decrease the excretion rate of Emtricitabine which could result in a higher serum level.
Memantine	Memantine Fentanyl may decrease the excretion rate of Memantine which could result in a higher serum level.
Tegaserod	Tegaserod The risk or severity of serotonin syndrome can be increased when Fentanyl is combined with Tegaserod.
Tadalafil	Tadalafil Fentanyl may decrease the antihypertensive activities of Tadalafil.
Frovatriptan	Frovatriptan The risk or severity of adverse effects can be increased when Fentanyl is combined with Frovatriptan.
Progesterone	Progesterone The metabolism of Fentanyl can be decreased when combined with Progesterone.
Apomorphine Injection	Apomorphine Injection The risk or severity of adverse effects can be increased when Apomorphine is combined with Fentanyl.
Infliximab Injection	Infliximab Injection The metabolism of Fentanyl can be increased when combined with Infliximab.
Protriptyline	Protriptyline The risk or severity of adverse effects can be increased when Protriptyline is combined with Fentanyl.
Duloxetine	Duloxetine The metabolism of Fentanyl can be decreased when combined with Duloxetine.
Norethindrone	Norethindrone The metabolism of Fentanyl can be decreased when combined with Norethisterone.
Tinidazole	Tinidazole Fentanyl may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Trospium	Trospium The risk or severity of adverse effects can be increased when Fentanyl is combined with Trospium.
Bosentan	Bosentan Fentanyl may decrease the antihypertensive activities of Bosentan.
Cefditoren	Cefditoren Cefdinir may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Cyanocobalamin Injection	Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Erlotinib	Erlotinib The metabolism of Fentanyl can be decreased when combined with Erlotinib.
Eszopiclone	Eszopiclone The risk or severity of CNS depression can be increased when Fentanyl is combined with Eszopiclone.
Ganciclovir	Ganciclovir Fentanyl may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Ribavirin	Ribavirin Ribavirin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Solifenacin	Solifenacin The risk or severity of adverse effects can be increased when Solifenacin is combined with Fentanyl.
Valganciclovir	Valganciclovir Fentanyl may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Voriconazole	Voriconazole The metabolism of Fentanyl can be decreased when combined with Voriconazole.
Adefovir	Adefovir Adefovir may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Dextroamphetamine	Dextroamphetamine The risk or severity of adverse effects can be increased when Amphetamine is combined with Fentanyl.
Sodium Oxybate	Sodium Oxybate Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Fentanyl.
Isocarboxazid	Isocarboxazid The risk or severity of adverse effects can be increased when Isocarboxazid is combined with Fentanyl.
Ramelteon	Ramelteon The risk or severity of adverse effects can be increased when Fentanyl is combined with Ramelteon.
Darifenacin	Darifenacin The risk or severity of adverse effects can be increased when Darifenacin is combined with Fentanyl.
Pregabalin	Pregabalin The therapeutic efficacy of Fentanyl can be increased when used in combination with Pregabalin.
Phenylephrine	Phenylephrine The therapeutic efficacy of Fentanyl can be decreased when used in combination with Phenylephrine.
Tipranavir	Tipranavir The metabolism of Fentanyl can be decreased when combined with Tipranavir.
Felbamate	Felbamate The risk or severity of adverse effects can be increased when Fentanyl is combined with Felbamate.
Ranolazine	Ranolazine The metabolism of Ranolazine can be decreased when combined with Fentanyl.
Abatacept Injection	Abatacept Injection The metabolism of Fentanyl can be increased when combined with Abatacept.
Rasagiline	Rasagiline The risk or severity of adverse effects can be increased when Rasagiline is combined with Fentanyl.
Imatinib	Imatinib The metabolism of Fentanyl can be decreased when combined with Imatinib.
Sitagliptin	Sitagliptin Fentanyl may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Varenicline	Varenicline Fentanyl may decrease the excretion rate of Varenicline which could result in a higher serum level.
Gefitinib	Gefitinib The metabolism of Fentanyl can be decreased when combined with Gefitinib.
Albuterol	Albuterol The risk or severity of hypertension can be increased when Fentanyl is combined with Salbutamol.
Paliperidone	Paliperidone The risk or severity of adverse effects can be increased when Fentanyl is combined with Paliperidone.
Clofarabine Injection	Clofarabine Injection Clofarabine may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Lubiprostone	Lubiprostone The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Fentanyl.
Posaconazole	Posaconazole The metabolism of Fentanyl can be decreased when combined with Posaconazole.
Primaquine	Primaquine The metabolism of Fentanyl can be decreased when combined with Primaquine.
Aliskiren	Aliskiren Fentanyl may decrease the antihypertensive activities of Aliskiren.
Darunavir	Darunavir The metabolism of Fentanyl can be decreased when combined with Darunavir.
Pemetrexed Injection	Pemetrexed Injection Pemetrexed may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Dimenhydrinate	Dimenhydrinate The risk or severity of adverse effects can be increased when Fentanyl is combined with Dimenhydrinate.
Lisdexamfetamine	Lisdexamfetamine Lisdexamfetamine may increase the analgesic activities of Fentanyl.
Nabilone	Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Fentanyl.
Sorafenib	Sorafenib The metabolism of Fentanyl can be decreased when combined with Sorafenib.
Sunitinib	Sunitinib The metabolism of Fentanyl can be decreased when combined with Sunitinib.
Dronabinol	Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Fentanyl.
Lapatinib	Lapatinib The metabolism of Fentanyl can be decreased when combined with Lapatinib.
Levocetirizine	Levocetirizine The risk or severity of adverse effects can be increased when Fentanyl is combined with Levocetirizine.
Pegaptanib Injection	Pegaptanib Injection Fentanyl may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Dasatinib	Dasatinib The metabolism of Fentanyl can be decreased when combined with Dasatinib.
Armodafinil	Armodafinil The metabolism of Fentanyl can be increased when combined with Armodafinil.
Azacitidine Injection	Azacitidine Injection Fentanyl may decrease the excretion rate of Azacitidine which could result in a higher serum level.
Paclitaxel (with polyoxyethylated castor oil) Injection	Paclitaxel (with polyoxyethylated castor oil) Injection The therapeutic efficacy of Castor oil can be decreased when used in combination with Fentanyl.
Temsirolimus	Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Fentanyl.
Lenalidomide	Lenalidomide Lenalidomide may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Nilotinib	Nilotinib The metabolism of Fentanyl can be decreased when combined with Nilotinib.
Budesonide	Budesonide The metabolism of Fentanyl can be increased when combined with Budesonide.
Chloramphenicol Injection	Chloramphenicol Injection The metabolism of Fentanyl can be decreased when combined with Chloramphenicol.
Desmopressin	Desmopressin The risk or severity of hyponatremia can be increased when Fentanyl is combined with Desmopressin.
OnabotulinumtoxinA Injection	OnabotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Fentanyl.
RimabotulinumtoxinB Injection	RimabotulinumtoxinB Injection The risk or severity of adverse effects can be increased when Botulinum Toxin Type B is combined with Fentanyl.
Doripenem Injection	Doripenem Injection Fentanyl may decrease the excretion rate of Doripenem which could result in a higher serum level.
Arsenic Trioxide Injection	Arsenic Trioxide Injection Fentanyl may decrease the excretion rate of Arsenic trioxide which could result in a higher serum level.
Mitoxantrone Injection	Mitoxantrone Injection The metabolism of Fentanyl can be decreased when combined with Mitoxantrone.
Desvenlafaxine	Desvenlafaxine The metabolism of Fentanyl can be decreased when combined with Desvenlafaxine.
Cevimeline	Cevimeline Cevimeline may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Nebivolol	Nebivolol Fentanyl may decrease the antihypertensive activities of Nebivolol.
Tretinoin	Tretinoin The metabolism of Fentanyl can be decreased when combined with Tretinoin.
Pilocarpine	Pilocarpine The metabolism of Fentanyl can be decreased when combined with Pilocarpine.
Certolizumab Injection	Certolizumab Injection The metabolism of Fentanyl can be increased when combined with Certolizumab pegol.
Irinotecan Injection	Irinotecan Injection The metabolism of Fentanyl can be decreased when combined with Irinotecan.
Daptomycin Injection	Daptomycin Injection Daptomycin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Praziquantel	Praziquantel The metabolism of Praziquantel can be decreased when combined with Fentanyl.
Alvimopan	Alvimopan The risk or severity of adverse effects can be increased when Fentanyl is combined with Alvimopan.
Methylnaltrexone Injection	Methylnaltrexone Injection The therapeutic efficacy of Methylnaltrexone can be decreased when used in combination with Fentanyl.
Rufinamide	Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Fentanyl.
Midazolam	Midazolam The metabolism of Fentanyl can be decreased when combined with Midazolam.
Naltrexone Injection	Naltrexone Injection The risk or severity of adverse effects can be increased when Naltrexone is combined with Fentanyl.
Dexrazoxane Injection	Dexrazoxane Injection Dexrazoxane may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Milnacipran	Milnacipran The metabolism of Fentanyl can be decreased when combined with Milnacipran.
Plerixafor Injection	Plerixafor Injection Fentanyl may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Sodium Phosphate	Sodium Phosphate The therapeutic efficacy of Sodium phosphate, monobasic can be decreased when used in combination with Fentanyl.
Fesoterodine	Fesoterodine The risk or severity of adverse effects can be increased when Fesoterodine is combined with Fentanyl.
Betaxolol	Betaxolol Betaxolol may increase the bradycardic activities of Fentanyl.
Iloperidone	Iloperidone The risk or severity of adverse effects can be increased when Fentanyl is combined with Iloperidone.
Prasugrel	Prasugrel Fentanyl may decrease the excretion rate of Prasugrel which could result in a higher serum level.
Lacosamide	Lacosamide The risk or severity of adverse effects can be increased when Fentanyl is combined with Lacosamide.
Everolimus	Everolimus The metabolism of Everolimus can be decreased when combined with Fentanyl.
Tolvaptan (low blood sodium)	Tolvaptan (low blood sodium) Tolvaptan may increase the excretion rate of Fentanyl which could result in a lower serum level and potentially a reduction in efficacy.
Dronedarone	Dronedarone The metabolism of Fentanyl can be decreased when combined with Dronedarone.
AbobotulinumtoxinA Injection	AbobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Fentanyl.
Pralatrexate Injection	Pralatrexate Injection Fentanyl may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Palonosetron Injection	Palonosetron Injection The risk or severity of adverse effects can be increased when Palonosetron is combined with Fentanyl.
Saxagliptin	Saxagliptin The metabolism of Saxagliptin can be decreased when combined with Fentanyl.
Telavancin Injection	Telavancin Injection Fentanyl may decrease the excretion rate of Telavancin which could result in a higher serum level.
Romidepsin Injection	Romidepsin Injection The metabolism of Romidepsin can be decreased when combined with Fentanyl.
Tapentadol	Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Fentanyl.
Topotecan	Topotecan The metabolism of Fentanyl can be decreased when combined with Topotecan.
Golimumab Injection	Golimumab Injection The metabolism of Fentanyl can be increased when combined with Golimumab.
Pazopanib	Pazopanib The metabolism of Fentanyl can be decreased when combined with Pazopanib.
Asenapine	Asenapine The risk or severity of adverse effects can be increased when Fentanyl is combined with Asenapine.
Vigabatrin	Vigabatrin The risk or severity of adverse effects can be increased when Fentanyl is combined with Vigabatrin.
Levonorgestrel	Levonorgestrel The metabolism of Fentanyl can be decreased when combined with Levonorgestrel.
Oxymorphone	Oxymorphone The risk or severity of adverse effects can be increased when Fentanyl is combined with Oxymorphone.
Tocilizumab Injection	Tocilizumab Injection The metabolism of Fentanyl can be increased when combined with Tocilizumab.
Dalfampridine	Dalfampridine The risk or severity of seizure can be increased when Dalfampridine is combined with Fentanyl.
Fingolimod	Fingolimod Fentanyl may increase the bradycardic activities of Fingolimod.
IncobotulinumtoxinA Injection	IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Fentanyl.
Cabazitaxel Injection	Cabazitaxel Injection The metabolism of Cabazitaxel can be decreased when combined with Fentanyl.
Ceftaroline Injection	Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Lurasidone	Lurasidone The risk or severity of adverse effects can be increased when Fentanyl is combined with Lurasidone.
Acetaminophen Injection	Acetaminophen Injection The metabolism of Fentanyl can be decreased when combined with Acetaminophen.
Vilazodone	Vilazodone The risk or severity of adverse effects can be increased when Fentanyl is combined with Vilazodone.
Ipilimumab Injection	Ipilimumab Injection Fentanyl may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Denileukin Diftitox Injection	Denileukin Diftitox Injection The metabolism of Fentanyl can be decreased when combined with Aldesleukin.
Terbutaline Injection	Terbutaline Injection The risk or severity of hypertension can be increased when Fentanyl is combined with Terbutaline.
Roflumilast	Roflumilast Fentanyl may decrease the excretion rate of Roflumilast which could result in a higher serum level.
Linagliptin	Linagliptin The metabolism of Fentanyl can be decreased when combined with Linagliptin.
Rilpivirine	Rilpivirine The metabolism of Fentanyl can be decreased when combined with Rilpivirine.
Cyclophosphamide Injection	Cyclophosphamide Injection The metabolism of Fentanyl can be decreased when combined with Cyclophosphamide.
Rivaroxaban	Rivaroxaban The metabolism of Rivaroxaban can be decreased when combined with Fentanyl.
Ticagrelor	Ticagrelor The metabolism of Fentanyl can be decreased when combined with Ticagrelor.
Brentuximab Vedotin Injection	Brentuximab Vedotin Injection The metabolism of Fentanyl can be decreased when combined with Brentuximab vedotin.
Ruxolitinib	Ruxolitinib Ruxolitinib may increase the bradycardic activities of Fentanyl.
Clobazam	Clobazam The risk or severity of adverse effects can be increased when Fentanyl is combined with Clobazam.
Ivacaftor	Ivacaftor The metabolism of Fentanyl can be decreased when combined with Ivacaftor.
Deferiprone	Deferiprone Fentanyl may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Axitinib	Axitinib The metabolism of Axitinib can be decreased when combined with Fentanyl.
Crizotinib	Crizotinib The metabolism of Fentanyl can be decreased when combined with Crizotinib.
Cabergoline	Cabergoline The metabolism of Fentanyl can be decreased when combined with Cabergoline.
Naloxone Injection	Naloxone Injection The metabolism of Fentanyl can be decreased when combined with Naloxone.
Ambrisentan	Ambrisentan Fentanyl may decrease the antihypertensive activities of Ambrisentan.
Fondaparinux Injection	Fondaparinux Injection Fondaparinux may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Ezogabine	Ezogabine The risk or severity of adverse effects can be increased when Fentanyl is combined with Tiagabine.
Enzalutamide	Enzalutamide The metabolism of Enzalutamide can be decreased when combined with Fentanyl.
Mirabegron	Mirabegron The risk or severity of hypertension can be increased when Fentanyl is combined with Mirabegron.
Regorafenib	Regorafenib The metabolism of Fentanyl can be decreased when combined with Regorafenib.
Bosutinib	Bosutinib The metabolism of Fentanyl can be decreased when combined with Bosutinib.
Linaclotide	Linaclotide The therapeutic efficacy of Linaclotide can be decreased when used in combination with Fentanyl.
Teduglutide Injection	Teduglutide Injection Fentanyl may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Tofacitinib	Tofacitinib Fentanyl may increase the bradycardic activities of Tofacitinib.
Alogliptin	Alogliptin Fentanyl may decrease the excretion rate of Alogliptin which could result in a higher serum level.
Ponatinib	Ponatinib The metabolism of Ponatinib can be decreased when combined with Fentanyl.
Pomalidomide	Pomalidomide The risk or severity of adverse effects can be increased when Fentanyl is combined with Pomalidomide.
Ado-trastuzumab Emtansine Injection	Ado-trastuzumab Emtansine Injection The metabolism of Fentanyl can be decreased when combined with Trastuzumab emtansine.
Apixaban	Apixaban The metabolism of Apixaban can be decreased when combined with Fentanyl.
Canagliflozin	Canagliflozin Fentanyl may increase the excretion rate of Canagliflozin which could result in a lower serum level and potentially a reduction in efficacy.
Methazolamide	Methazolamide The therapeutic efficacy of Methazolamide can be decreased when used in combination with Fentanyl.
Trametinib	Trametinib Fentanyl may decrease the excretion rate of Trametinib which could result in a higher serum level.
Levomilnacipran	Levomilnacipran The risk or severity of serotonin syndrome can be increased when Levomilnacipran is combined with Fentanyl.
Ertapenem Injection	Ertapenem Injection Ertapenem may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Vortioxetine	Vortioxetine The risk or severity of adverse effects can be increased when Fentanyl is combined with Vortioxetine.
Perampanel	Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Fentanyl.
Ibrutinib	Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Fentanyl.
Lomitapide	Lomitapide The metabolism of Fentanyl can be decreased when combined with Lomitapide.
Ketorolac Injection	Ketorolac Injection Ketorolac may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Simeprevir	Simeprevir The metabolism of Fentanyl can be decreased when combined with Simeprevir.
Sofosbuvir	Sofosbuvir Fentanyl may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin	Dapagliflozin Dapagliflozin may increase the excretion rate of Fentanyl which could result in a lower serum level and potentially a reduction in efficacy.
Apremilast	Apremilast The metabolism of Fentanyl can be increased when combined with Apremilast.
Droxidopa	Droxidopa The therapeutic efficacy of Fentanyl can be decreased when used in combination with Droxidopa.
Ceritinib	Ceritinib The metabolism of Fentanyl can be decreased when combined with Ceritinib.
Siltuximab Injection	Siltuximab Injection The metabolism of Fentanyl can be decreased when combined with Siltuximab.
Eslicarbazepine	Eslicarbazepine The risk or severity of adverse effects can be increased when Fentanyl is combined with Eslicarbazepine.
Idelalisib	Idelalisib The metabolism of Fentanyl can be decreased when combined with Idelalisib.
Testosterone Injection	Testosterone Injection The metabolism of Fentanyl can be decreased when combined with Testosterone.
Hydrocodone	Hydrocodone Hydrocodone may increase the central nervous system depressant (CNS depressant) activities of Fentanyl.
Suvorexant	Suvorexant Fentanyl may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Edoxaban	Edoxaban Fentanyl may decrease the excretion rate of Edoxaban which could result in a higher serum level.
Olaparib	Olaparib The metabolism of Fentanyl can be decreased when combined with Olaparib.
Methamphetamine	Methamphetamine The risk or severity of adverse effects can be increased when Fentanyl is combined with Metamfetamine.
Tasimelteon	Tasimelteon The risk or severity of adverse effects can be increased when Fentanyl is combined with Tasimelteon.
Riociguat	Riociguat Fentanyl may decrease the antihypertensive activities of Riociguat.
Lanreotide Injection	Lanreotide Injection The metabolism of Fentanyl can be decreased when combined with Lanreotide.
Secukinumab Injection	Secukinumab Injection The metabolism of Fentanyl can be increased when combined with Secukinumab.
Risperidone Injection	Risperidone Injection The risk or severity of adverse effects can be increased when Risperidone is combined with Fentanyl.
Palbociclib	Palbociclib The metabolism of Fentanyl can be decreased when combined with Palbociclib.
Lenvatinib	Lenvatinib The metabolism of Fentanyl can be decreased when combined with Lenvatinib.
Naloxegol	Naloxegol The therapeutic efficacy of Fentanyl can be decreased when used in combination with Naloxegol.
Haloperidol Injection	Haloperidol Injection The metabolism of Fentanyl can be decreased when combined with Haloperidol.
Ivabradine	Ivabradine Fentanyl may increase the bradycardic activities of Ivabradine.
Amiloride	Amiloride Amiloride may increase the excretion rate of Fentanyl which could result in a lower serum level and potentially a reduction in efficacy.
Isavuconazonium Injection	Isavuconazonium Injection The metabolism of Fentanyl can be decreased when combined with Isavuconazonium.
Macitentan	Macitentan Fentanyl may decrease the antihypertensive activities of Macitentan.
Flibanserin	Flibanserin The risk or severity of adverse effects can be increased when Fentanyl is combined with Flibanserin.
Daclatasvir	Daclatasvir The metabolism of Daclatasvir can be decreased when combined with Fentanyl.
Brexpiprazole	Brexpiprazole The risk or severity of adverse effects can be increased when Fentanyl is combined with Brexpiprazole.
Ziprasidone Injection	Ziprasidone Injection The metabolism of Fentanyl can be decreased when combined with Ziprasidone.
Cariprazine	Cariprazine The risk or severity of adverse effects can be increased when Fentanyl is combined with Cariprazine.
Penicillin G Procaine Injection	Penicillin G Procaine Injection Fentanyl may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Eluxadoline	Eluxadoline The risk or severity of constipation can be increased when Fentanyl is combined with Eluxadoline.
Osimertinib	Osimertinib The metabolism of Fentanyl can be decreased when combined with Osimertinib.
Ixazomib	Ixazomib Fentanyl may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Lesinurad	Lesinurad Fentanyl may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amphotericin B Liposomal Injection	Amphotericin B Liposomal Injection The metabolism of Fentanyl can be decreased when combined with Amphotericin B.
Dexamethasone Injection	Dexamethasone Injection The metabolism of Fentanyl can be decreased when combined with Dexamethasone.
Brivaracetam Injection	Brivaracetam Injection The risk or severity of adverse effects can be increased when Fentanyl is combined with Brivaracetam.
Venetoclax	Venetoclax The metabolism of Fentanyl can be decreased when combined with Venetoclax.
Cobicistat	Cobicistat The metabolism of Fentanyl can be decreased when combined with Cobicistat.
Midodrine	Midodrine The therapeutic efficacy of Fentanyl can be decreased when used in combination with Midodrine.
Selexipag	Selexipag Fentanyl may decrease the antihypertensive activities of Selexipag.
Pimavanserin	Pimavanserin The risk or severity of adverse effects can be increased when Fentanyl is combined with Pimavanserin.
Diphenhydramine Injection	Diphenhydramine Injection The risk or severity of adverse effects can be increased when Fentanyl is combined with Diphenhydramine.
Furosemide Injection	Furosemide Injection Fentanyl may decrease the excretion rate of Furosemide which could result in a higher serum level.
Rucaparib	Rucaparib The metabolism of Fentanyl can be decreased when combined with Rucaparib.
Lixisenatide Injection	Lixisenatide Injection Fentanyl may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Ribociclib	Ribociclib The metabolism of Fentanyl can be decreased when combined with Ribociclib.
Doxepin (Insomnia)	Doxepin (Insomnia) The risk or severity of adverse effects can be increased when Fentanyl is combined with Doxepin.
Plecanatide	Plecanatide The therapeutic efficacy of Plecanatide can be decreased when used in combination with Fentanyl.
Deutetrabenazine	Deutetrabenazine The metabolism of Deutetrabenazine can be decreased when combined with Fentanyl.
Valbenazine	Valbenazine The metabolism of Valbenazine can be decreased when combined with Fentanyl.
Deflazacort	Deflazacort The metabolism of Fentanyl can be increased when combined with Deflazacort.
Safinamide	Safinamide The risk or severity of adverse effects can be increased when Safinamide is combined with Fentanyl.
Naldemedine	Naldemedine The therapeutic efficacy of Naldemedine can be decreased when used in combination with Fentanyl.
Sarilumab Injection	Sarilumab Injection The metabolism of Fentanyl can be decreased when combined with Sarilumab.
Midostaurin	Midostaurin The metabolism of Fentanyl can be decreased when combined with Midostaurin.
Enasidenib	Enasidenib The metabolism of Fentanyl can be decreased when combined with Enasidenib.
Aprepitant/Fosaprepitant Injection	Aprepitant/Fosaprepitant Injection The metabolism of Fentanyl can be decreased when combined with Fosaprepitant.
Benznidazole	Benznidazole Fentanyl may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Copanlisib Injection	Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Fentanyl.
Delafloxacin	Delafloxacin Fentanyl may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Acalabrutinib	Acalabrutinib The metabolism of Fentanyl can be decreased when combined with Acalabrutinib.
Letermovir	Letermovir The metabolism of Fentanyl can be decreased when combined with Letermovir.
Ertugliflozin	Ertugliflozin Ertugliflozin may increase the excretion rate of Fentanyl which could result in a lower serum level and potentially a reduction in efficacy.
Buprenorphine Injection	Buprenorphine Injection The metabolism of Fentanyl can be decreased when combined with Buprenorphine.
Apalutamide	Apalutamide Fentanyl may decrease the excretion rate of Apalutamide which could result in a higher serum level.
Fostamatinib	Fostamatinib The metabolism of Fentanyl can be decreased when combined with Fostamatinib.
Baricitinib	Baricitinib Fentanyl may decrease the excretion rate of Baricitinib which could result in a higher serum level.
Lofexidine	Lofexidine The therapeutic efficacy of Fentanyl can be increased when used in combination with Lofexidine.
Plazomicin Injection	Plazomicin Injection Fentanyl may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Doravirine	Doravirine The metabolism of Doravirine can be decreased when combined with Fentanyl.
Cannabidiol	Cannabidiol The risk or severity of adverse effects can be increased when Cannabidiol is combined with Fentanyl.
Stiripentol	Stiripentol The metabolism of Fentanyl can be decreased when combined with Stiripentol.
Gilteritinib	Gilteritinib The therapeutic efficacy of Fentanyl can be decreased when used in combination with Gilteritinib.
Lorlatinib	Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Fentanyl.
Paclitaxel (with albumin) Injection	Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Fentanyl.
Rifamycin	Rifamycin The metabolism of Fentanyl can be decreased when combined with Rifamycin.
Prucalopride	Prucalopride The therapeutic efficacy of Prucalopride can be decreased when used in combination with Fentanyl.
Magnesium Citrate	Magnesium Citrate The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Fentanyl.
Emapalumab-lzsg Injection	Emapalumab-lzsg Injection The metabolism of Fentanyl can be increased when combined with Emapalumab.
Siponimod	Siponimod The risk or severity of hypertension can be increased when Fentanyl is combined with Siponimod.
Acyclovir Ophthalmic	Acyclovir Ophthalmic Acyclovir may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Alpelisib	Alpelisib The metabolism of Fentanyl can be decreased when combined with Alpelisib.
Brexanolone Injection	Brexanolone Injection The risk or severity of adverse effects can be increased when Fentanyl is combined with Brexanolone.
Solriamfetol	Solriamfetol The risk or severity of hypertension can be increased when Solriamfetol is combined with Fentanyl.
Triclabendazole	Triclabendazole The metabolism of Fentanyl can be decreased when combined with Triclabendazole.
Istradefylline	Istradefylline The metabolism of Istradefylline can be decreased when combined with Fentanyl.
Pitolisant	Pitolisant The serum concentration of Fentanyl can be decreased when it is combined with Pitolisant.
Phenytoin Injection	Phenytoin Injection The risk or severity of adverse effects can be increased when Phenytoin is combined with Fentanyl.
Fosphenytoin Injection	Fosphenytoin Injection The risk or severity of adverse effects can be increased when Fentanyl is combined with Fosphenytoin.
Lumateperone	Lumateperone The risk or severity of adverse effects can be increased when Fentanyl is combined with Lumateperone.
Lasmiditan	Lasmiditan The risk or severity of serotonin syndrome can be increased when Fentanyl is combined with Lasmiditan.
Cenobamate	Cenobamate The metabolism of Fentanyl can be decreased when combined with Cenobamate.
Selumetinib	Selumetinib The metabolism of Selumetinib can be decreased when combined with Fentanyl.
Tucatinib	Tucatinib The metabolism of Tucatinib can be decreased when combined with Fentanyl.
Remdesivir Injection	Remdesivir Injection The metabolism of Fentanyl can be decreased when combined with Remdesivir.
Selpercatinib	Selpercatinib The risk or severity of hypertension can be increased when Fentanyl is combined with Selpercatinib.
Lemborexant	Lemborexant The risk or severity of adverse effects can be increased when Fentanyl is combined with Lemborexant.
Fenfluramine	Fenfluramine The risk or severity of serotonin syndrome can be increased when Fenfluramine is combined with Fentanyl.
Octreotide	Octreotide The metabolism of Fentanyl can be decreased when combined with Octreotide.
Pralsetinib	Pralsetinib The metabolism of Fentanyl can be decreased when combined with Pralsetinib.
Satralizumab-mwge Injection	Satralizumab-mwge Injection The serum concentration of Fentanyl can be decreased when it is combined with Satralizumab.
Naxitamab-gqgk Injection	Naxitamab-gqgk Injection The risk or severity of hypertension can be increased when Fentanyl is combined with Naxitamab.
Progestin-Only (drospirenone) Oral Contraceptives	Progestin-Only (drospirenone) Oral Contraceptives Drospirenone may increase the excretion rate of Fentanyl which could result in a lower serum level and potentially a reduction in efficacy.
Viloxazine	Viloxazine The risk or severity of adverse effects can be increased when Fentanyl is combined with Viloxazine.
Tobramycin Injection	Tobramycin Injection Tobramycin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Fenoprofen	Fenoprofen Fenoprofen may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Indomethacin	Indomethacin Indomethacin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Mefenamic Acid	Mefenamic Acid Mefenamic acid may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Naproxen	Naproxen Naproxen may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Tolmetin	Tolmetin Tolmetin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Sulindac	Sulindac Sulindac may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Trazodone	Trazodone The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Fentanyl.
Isotretinoin	Isotretinoin Fentanyl may decrease the excretion rate of Isotretinoin which could result in a higher serum level.
Sucralfate	Sucralfate Sucralfate may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Floxuridine	Floxuridine Floxuridine may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Phenobarbital	Phenobarbital The risk or severity of adverse effects can be increased when Fentanyl is combined with Phenobarbital.
Metaxalone	Metaxalone The risk or severity of adverse effects can be increased when Metaxalone is combined with Fentanyl.
Methotrexate Injection	Methotrexate Injection Methotrexate may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Levorphanol	Levorphanol The risk or severity of adverse effects can be increased when Fentanyl is combined with Levorphanol.
Primidone	Primidone The risk or severity of adverse effects can be increased when Primidone is combined with Fentanyl.
Methsuximide	Methsuximide The risk or severity of adverse effects can be increased when Fentanyl is combined with Methsuximide.
Diethylpropion	Diethylpropion Diethylpropion may increase the analgesic activities of Fentanyl.
Chlorpromazine	Chlorpromazine The risk or severity of adverse effects can be increased when Chlorpromazine is combined with Fentanyl.
Diazepam	Diazepam The metabolism of Fentanyl can be decreased when combined with Diazepam.
Oxazepam	Oxazepam The risk or severity of adverse effects can be increased when Fentanyl is combined with Oxazepam.
Flurazepam	Flurazepam The risk or severity of adverse effects can be increased when Fentanyl is combined with Flurazepam.
Clorazepate	Clorazepate The risk or severity of adverse effects can be increased when Fentanyl is combined with Clorazepic acid.
Lorazepam	Lorazepam The risk or severity of adverse effects can be increased when Fentanyl is combined with Lorazepam.
Phenoxybenzamine	Phenoxybenzamine The risk or severity of hypertension can be increased when Fentanyl is combined with Phenoxybenzamine.
Carmustine	Carmustine Carmustine may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Amantadine	Amantadine The risk or severity of adverse effects can be increased when Amantadine is combined with Fentanyl.
Codeine	Codeine The risk or severity of adverse effects can be increased when Codeine is combined with Fentanyl.
Meprobamate	Meprobamate The risk or severity of adverse effects can be increased when Meprobamate is combined with Fentanyl.
Chlordiazepoxide	Chlordiazepoxide The risk or severity of adverse effects can be increased when Fentanyl is combined with Chlordiazepoxide.
Bromocriptine	Bromocriptine The metabolism of Fentanyl can be decreased when combined with Bromocriptine.
Metaproterenol	Metaproterenol The risk or severity of hypertension can be increased when Fentanyl is combined with Orciprenaline.
Tranylcypromine	Tranylcypromine The metabolism of Fentanyl can be decreased when combined with Tranylcypromine.
Phenelzine	Phenelzine The metabolism of Fentanyl can be decreased when combined with Phenelzine.
Procarbazine	Procarbazine The risk or severity of adverse effects can be increased when Procarbazine is combined with Fentanyl.
Ergoloid Mesylates	Ergoloid Mesylates The risk or severity of adverse effects can be increased when Fentanyl is combined with Ergoloid mesylate.
Tetracycline	Tetracycline The metabolism of Fentanyl can be decreased when combined with Tetracycline.
Minocycline	Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Fentanyl.
Prochlorperazine	Prochlorperazine The risk or severity of adverse effects can be increased when Prochlorperazine is combined with Fentanyl.
Thioridazine	Thioridazine The risk or severity of hypotension and CNS depression can be increased when Thioridazine is combined with Fentanyl.
Trifluoperazine	Trifluoperazine The risk or severity of hypotension and CNS depression can be increased when Trifluoperazine is combined with Fentanyl.
Bleomycin	Bleomycin Bleomycin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Dapsone	Dapsone The metabolism of Fentanyl can be decreased when combined with Dapsone.
Sulfadiazine	Sulfadiazine Sulfadiazine may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Oxycodone	Oxycodone The risk or severity of adverse effects can be increased when Oxycodone is combined with Fentanyl.
Methadone	Methadone The metabolism of Fentanyl can be decreased when combined with Methadone.
Oxybutynin	Oxybutynin The metabolism of Fentanyl can be decreased when combined with Oxybutynin.
Benztropine	Benztropine The risk or severity of adverse effects can be increased when Benzatropine is combined with Fentanyl.
Maprotiline	Maprotiline The risk or severity of adverse effects can be increased when Maprotiline is combined with Fentanyl.
Ibuprofen	Ibuprofen Fentanyl may decrease the excretion rate of Ibuprofen which could result in a higher serum level.
Trihexyphenidyl	Trihexyphenidyl The risk or severity of adverse effects can be increased when Fentanyl is combined with Trihexyphenidyl.
Orphenadrine	Orphenadrine The metabolism of Fentanyl can be decreased when combined with Orphenadrine.
Perphenazine	Perphenazine The risk or severity of adverse effects can be increased when Fentanyl is combined with Perphenazine.
Azathioprine	Azathioprine Fentanyl may decrease the excretion rate of Azathioprine which could result in a higher serum level.
Fluphenazine	Fluphenazine The risk or severity of hypotension and CNS depression can be increased when Fluphenazine is combined with Fentanyl.
Phentermine	Phentermine Phentermine may increase the analgesic activities of Fentanyl.
Methylphenidate	Methylphenidate The risk or severity of hypertension can be increased when Methylphenidate is combined with Fentanyl.
Amoxapine	Amoxapine The risk or severity of adverse effects can be increased when Amoxapine is combined with Fentanyl.
Sulfasalazine	Sulfasalazine Sulfasalazine may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Hydrocortisone	Hydrocortisone The metabolism of Fentanyl can be decreased when combined with Hydrocortisone.
Doxorubicin	Doxorubicin The metabolism of Fentanyl can be decreased when combined with Doxorubicin.
Phenazopyridine	Phenazopyridine Phenazopyridine may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Carbamazepine	Carbamazepine The metabolism of Fentanyl can be decreased when combined with Carbamazepine.
Molindone	Molindone The risk or severity of adverse effects can be increased when Fentanyl is combined with Molindone.
Methyldopa	Methyldopa Fentanyl may decrease the antihypertensive activities of Methyldopa.
Clonidine	Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Fentanyl.
Prazosin	Prazosin Fentanyl may decrease the antihypertensive activities of Prazosin.
Hydralazine	Hydralazine The metabolism of Fentanyl can be decreased when combined with Hydralazine.
Cimetidine	Cimetidine The metabolism of Fentanyl can be decreased when combined with Cimetidine.
Gentamicin Injection	Gentamicin Injection Gentamicin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Warfarin	Warfarin Fentanyl may decrease the excretion rate of Warfarin which could result in a higher serum level.
Clonazepam	Clonazepam The risk or severity of adverse effects can be increased when Fentanyl is combined with Clonazepam.
Loperamide	Loperamide The metabolism of Fentanyl can be decreased when combined with Loperamide.
Promethazine	Promethazine The risk or severity of adverse effects can be increased when Promethazine is combined with Fentanyl.
Meclofenamate	Meclofenamate Fentanyl may decrease the excretion rate of Meclofenamic acid which could result in a higher serum level.
Daunorubicin	Daunorubicin The metabolism of Fentanyl can be decreased when combined with Daunorubicin.
Nitrofurantoin	Nitrofurantoin Nitrofurantoin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Digoxin	Digoxin Digoxin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Loxapine	Loxapine The risk or severity of adverse effects can be increased when Loxapine is combined with Fentanyl.
Chloroquine	Chloroquine The metabolism of Fentanyl can be decreased when combined with Chloroquine.
Quinine	Quinine The metabolism of Fentanyl can be decreased when combined with Quinine.
Ethosuximide	Ethosuximide The risk or severity of adverse effects can be increased when Ethosuximide is combined with Fentanyl.
Triamterene	Triamterene Triamterene may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Lactulose	Lactulose The therapeutic efficacy of Lactulose can be decreased when used in combination with Fentanyl.
Chlorothiazide	Chlorothiazide The therapeutic efficacy of Chlorothiazide can be decreased when used in combination with Fentanyl.
Chlorthalidone	Chlorthalidone The therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Fentanyl.
Metolazone	Metolazone Fentanyl may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Isosorbide	Isosorbide The therapeutic efficacy of Isosorbide can be decreased when used in combination with Fentanyl.
Clindamycin Injection	Clindamycin Injection The metabolism of Clindamycin can be decreased when combined with Fentanyl.
Secobarbital	Secobarbital The risk or severity of adverse effects can be increased when Secobarbital is combined with Fentanyl.
Desipramine	Desipramine The metabolism of Fentanyl can be decreased when combined with Desipramine.
Amitriptyline	Amitriptyline The risk or severity of adverse effects can be increased when Fentanyl is combined with Amitriptyline.
Imipramine	Imipramine The risk or severity of adverse effects can be increased when Fentanyl is combined with Imipramine.
Probenecid	Probenecid Fentanyl may decrease the excretion rate of Probenecid which could result in a higher serum level.
Quinidine	Quinidine The metabolism of Fentanyl can be decreased when combined with Quinidine.
Procainamide	Procainamide Fentanyl may decrease the excretion rate of Procainamide which could result in a higher serum level.
Isoniazid	Isoniazid The metabolism of Fentanyl can be decreased when combined with Isoniazid.
Pyrazinamide	Pyrazinamide Pyrazinamide may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Rifampin	Rifampin The metabolism of Fentanyl can be increased when combined with Rifampicin.
Disopyramide	Disopyramide The risk or severity of adverse effects can be increased when Disopyramide is combined with Fentanyl.
Valproic Acid	Valproic Acid The metabolism of Fentanyl can be decreased when combined with Valproic acid.
Tamoxifen	Tamoxifen The metabolism of Fentanyl can be decreased when combined with Tamoxifen.
Butabarbital	Butabarbital The risk or severity of adverse effects can be increased when Butabarbital is combined with Fentanyl.
Liothyronine	Liothyronine Liothyronine may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Methimazole	Methimazole The metabolism of Fentanyl can be decreased when combined with Methimazole.
Chlorpropamide	Chlorpropamide Chlorpropamide may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Tolbutamide	Tolbutamide Fentanyl may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Tolazamide	Tolazamide Fentanyl may decrease the excretion rate of Tolazamide which could result in a higher serum level.
Dextromethorphan	Dextromethorphan The risk or severity of adverse effects can be increased when Dextromethorphan is combined with Fentanyl.
Cyclobenzaprine	Cyclobenzaprine The risk or severity of CNS depression can be increased when Fentanyl is combined with Cyclobenzaprine.
Baclofen	Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Fentanyl.
Doxylamine	Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Fentanyl.
Cyproheptadine	Cyproheptadine The risk or severity of adverse effects can be increased when Cyproheptadine is combined with Fentanyl.
Clemastine	Clemastine The risk or severity of adverse effects can be increased when Clemastine is combined with Fentanyl.
Chlorpheniramine	Chlorpheniramine The risk or severity of adverse effects can be increased when Fentanyl is combined with Chlorpheniramine.
Brompheniramine	Brompheniramine The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Fentanyl.
Meclizine	Meclizine The risk or severity of adverse effects can be increased when Meclizine is combined with Fentanyl.
Ethambutol	Ethambutol Ethambutol may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Methyclothiazide	Methyclothiazide The therapeutic efficacy of Methyclothiazide can be decreased when used in combination with Fentanyl.
Hydrochlorothiazide	Hydrochlorothiazide Fentanyl may decrease the excretion rate of Hydrochlorothiazide which could result in a higher serum level.
Dantrolene	Dantrolene The risk or severity of adverse effects can be increased when Fentanyl is combined with Dantrolene.
Chlorzoxazone	Chlorzoxazone The risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Fentanyl.
Carisoprodol	Carisoprodol The risk or severity of adverse effects can be increased when Carisoprodol is combined with Fentanyl.
Methocarbamol	Methocarbamol The risk or severity of adverse effects can be increased when Methocarbamol is combined with Fentanyl.
Pyridoxine	Pyridoxine Pyridoxine may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Folic Acid	Folic Acid Folic acid may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Danazol	Danazol The metabolism of Fentanyl can be decreased when combined with Danazol.
Disulfiram	Disulfiram The metabolism of Disulfiram can be decreased when combined with Fentanyl.
Propranolol (Cardiovascular)	Propranolol (Cardiovascular) Fentanyl may decrease the antihypertensive activities of Propranolol.
Minoxidil	Minoxidil Fentanyl may decrease the antihypertensive activities of Minoxidil.
Pseudoephedrine	Pseudoephedrine The therapeutic efficacy of Fentanyl can be decreased when used in combination with Pseudoephedrine.
Nortriptyline	Nortriptyline The risk or severity of adverse effects can be increased when Nortriptyline is combined with Fentanyl.
Spironolactone	Spironolactone Spironolactone may increase the excretion rate of Fentanyl which could result in a lower serum level and potentially a reduction in efficacy.
Amphotericin B Injection	Amphotericin B Injection The metabolism of Fentanyl can be decreased when combined with Amphotericin B.
Phytonadione	Phytonadione Fentanyl may decrease the excretion rate of Phylloquinone which could result in a higher serum level.
Amikacin Injection	Amikacin Injection Amikacin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Nadolol	Nadolol Fentanyl may decrease the antihypertensive activities of Nadolol.
Butorphanol Injection	Butorphanol Injection The therapeutic efficacy of Fentanyl can be decreased when used in combination with Butorphanol.
Nalbuphine Injection	Nalbuphine Injection The therapeutic efficacy of Nalbuphine can be decreased when used in combination with Fentanyl.
Allopurinol	Allopurinol Allopurinol may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Trimethobenzamide	Trimethobenzamide The risk or severity of adverse effects can be increased when Trimethobenzamide is combined with Fentanyl.
Flavoxate	Flavoxate The risk or severity of adverse effects can be increased when Flavoxate is combined with Fentanyl.
Colchicine	Colchicine The metabolism of Fentanyl can be decreased when combined with Colchicine.
Cefaclor	Cefaclor Cefaclor may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Cefadroxil	Cefadroxil Cefadroxil may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Cefazolin Injection	Cefazolin Injection Cefazolin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Cephalexin	Cephalexin Cephalexin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Cefoxitin Injection	Cefoxitin Injection Cefoxitin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Dacarbazine	Dacarbazine Fentanyl may decrease the excretion rate of Dacarbazine which could result in a higher serum level.
Acetazolamide	Acetazolamide The metabolism of Fentanyl can be decreased when combined with Acetazolamide.
Cefotaxime Injection	Cefotaxime Injection Cefotaxime may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Calcitonin Salmon Injection	Calcitonin Salmon Injection Salmon calcitonin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Ketoconazole	Ketoconazole The metabolism of Fentanyl can be decreased when combined with Ketoconazole.
Pyrantel	Pyrantel The risk or severity of adverse effects can be increased when Fentanyl is combined with Pyrantel.
Vincristine Injection	Vincristine Injection The metabolism of Fentanyl can be decreased when combined with Vincristine.
Captopril	Captopril Fentanyl may decrease the antihypertensive activities of Captopril.
Isoxsuprine	Isoxsuprine The risk or severity of hypertension can be increased when Fentanyl is combined with Isoxsuprine.
Vinblastine	Vinblastine The metabolism of Fentanyl can be decreased when combined with Vinblastine.
Ethacrynic Acid	Ethacrynic Acid Etacrynic acid may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Colistimethate Injection	Colistimethate Injection Colistimethate may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Metoprolol	Metoprolol Fentanyl may decrease the antihypertensive activities of Metoprolol.
Hydroxyzine	Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Fentanyl.
Thiothixene	Thiothixene The risk or severity of adverse effects can be increased when Fentanyl is combined with Thiothixene.
Aspirin	Aspirin Fentanyl may decrease the excretion rate of Acetylsalicylic acid which could result in a higher serum level.
Salsalate	Salsalate Fentanyl may decrease the excretion rate of Salsalate which could result in a higher serum level.
Alprazolam	Alprazolam The risk or severity of adverse effects can be increased when Fentanyl is combined with Alprazolam.
Temazepam	Temazepam The risk or severity of adverse effects can be increased when Fentanyl is combined with Temazepam.
Triazolam	Triazolam The risk or severity of adverse effects can be increased when Fentanyl is combined with Triazolam.
Dicyclomine	Dicyclomine The risk or severity of adverse effects can be increased when Dicyclomine is combined with Fentanyl.
Hyoscyamine	Hyoscyamine The risk or severity of adverse effects can be increased when Fentanyl is combined with Hyoscyamine.
Propantheline	Propantheline The risk or severity of adverse effects can be increased when Propantheline is combined with Fentanyl.
Trimethoprim	Trimethoprim Trimethoprim may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Diltiazem	Diltiazem The metabolism of Fentanyl can be decreased when combined with Diltiazem.
Nifedipine	Nifedipine Fentanyl may increase the bradycardic activities of Nifedipine.
Timolol	Timolol Fentanyl may decrease the antihypertensive activities of Timolol.
Verapamil	Verapamil The metabolism of Fentanyl can be decreased when combined with Verapamil.
Atenolol	Atenolol Fentanyl may decrease the antihypertensive activities of Atenolol.
Pindolol	Pindolol The risk or severity of adverse effects can be increased when Fentanyl is combined with Pindolol.
Cisplatin Injection	Cisplatin Injection Fentanyl may decrease the excretion rate of Cisplatin which could result in a higher serum level.
Diflunisal	Diflunisal Fentanyl may decrease the excretion rate of Diflunisal which could result in a higher serum level.
Piroxicam	Piroxicam Piroxicam may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Bumetanide	Bumetanide Bumetanide may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Etoposide	Etoposide The metabolism of Fentanyl can be decreased when combined with Etoposide.
Glyburide	Glyburide The metabolism of Fentanyl can be decreased when combined with Glyburide.
Glipizide	Glipizide Fentanyl may decrease the excretion rate of Glipizide which could result in a higher serum level.
Indapamide	Indapamide Fentanyl may increase the excretion rate of Indapamide which could result in a lower serum level and potentially a reduction in efficacy.
Amoxicillin	Amoxicillin Fentanyl may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Oxacillin Injection	Oxacillin Injection Oxacillin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Pentoxifylline	Pentoxifylline Pentoxifylline may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Pentamidine Injection	Pentamidine Injection Pentamidine may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Ceftriaxone Injection	Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Labetalol	Labetalol Fentanyl may decrease the antihypertensive activities of Labetalol.
Auranofin	Auranofin Fentanyl may decrease the excretion rate of Auranofin which could result in a higher serum level.
Leuprolide Injection	Leuprolide Injection Leuprolide may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Gemfibrozil	Gemfibrozil Fentanyl may decrease the excretion rate of Gemfibrozil which could result in a higher serum level.
Guanabenz	Guanabenz The risk or severity of hypertension can be increased when Guanabenz is combined with Fentanyl.
Dipivefrin Ophthalmic	Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Ceftazidime Injection	Ceftazidime Injection Ceftazidime may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Ketoprofen	Ketoprofen Fentanyl may decrease the excretion rate of Ketoprofen which could result in a higher serum level.
Cefotetan Injection	Cefotetan Injection Cefotetan may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Pimozide	Pimozide The metabolism of Fentanyl can be decreased when combined with Pimozide.
Enalapril	Enalapril Fentanyl may decrease the antihypertensive activities of Enalapril.
Flurbiprofen	Flurbiprofen Flurbiprofen may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Amiodarone	Amiodarone The risk or severity of adverse effects can be increased when Amiodarone is combined with Fentanyl.
Aztreonam Injection	Aztreonam Injection Aztreonam may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Buspirone	Buspirone The risk or severity of serotonin syndrome can be increased when Buspirone is combined with Fentanyl.
Lovastatin	Lovastatin The metabolism of Fentanyl can be decreased when combined with Lovastatin.
Ciprofloxacin	Ciprofloxacin The metabolism of Fentanyl can be decreased when combined with Ciprofloxacin.
Mesalamine	Mesalamine Mesalazine may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Diclofenac	Diclofenac Diclofenac may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Fluoxetine	Fluoxetine The risk or severity of serotonin syndrome can be increased when Fentanyl is combined with Fluoxetine.
Nimodipine	Nimodipine Fentanyl may decrease the antihypertensive activities of Nimodipine.
Clozapine	Clozapine The metabolism of Fentanyl can be decreased when combined with Clozapine.
Estazolam	Estazolam The risk or severity of adverse effects can be increased when Fentanyl is combined with Estazolam.
Didanosine	Didanosine Fentanyl may decrease the excretion rate of Didanosine which could result in a higher serum level.
Pentostatin Injection	Pentostatin Injection Pentostatin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Clarithromycin	Clarithromycin The metabolism of Fentanyl can be decreased when combined with Clarithromycin.
Benazepril	Benazepril Fentanyl may decrease the antihypertensive activities of Benazepril.
Etodolac	Etodolac Etodolac may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Felodipine	Felodipine The metabolism of Fentanyl can be decreased when combined with Felodipine.
Fosinopril	Fosinopril Fentanyl may decrease the antihypertensive activities of Fosinopril.
Nabumetone	Nabumetone Nabumetone may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Quinapril	Quinapril Fentanyl may decrease the antihypertensive activities of Quinapril.
Ramipril	Ramipril Fentanyl may decrease the antihypertensive activities of Ramipril.
Simvastatin	Simvastatin The metabolism of Fentanyl can be decreased when combined with Simvastatin.
Amlodipine	Amlodipine Fentanyl may decrease the antihypertensive activities of Amlodipine.
Teniposide Injection	Teniposide Injection The metabolism of Fentanyl can be decreased when combined with Teniposide.
Itraconazole	Itraconazole The metabolism of Fentanyl can be decreased when combined with Itraconazole.
Lisinopril	Lisinopril Fentanyl may decrease the antihypertensive activities of Lisinopril.
Oxaprozin	Oxaprozin Fentanyl may decrease the excretion rate of Oxaprozin which could result in a higher serum level.
Sotalol	Sotalol Sotalol may increase the bradycardic activities of Fentanyl.
Bisoprolol	Bisoprolol Fentanyl may decrease the antihypertensive activities of Bisoprolol.
Zolpidem	Zolpidem Fentanyl may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Doxazosin	Doxazosin Fentanyl may decrease the antihypertensive activities of Doxazosin.
Terazosin	Terazosin Fentanyl may decrease the antihypertensive activities of Terazosin.
Isradipine	Isradipine The metabolism of Fentanyl can be decreased when combined with Isradipine.
Omeprazole	Omeprazole The metabolism of Fentanyl can be decreased when combined with Omeprazole.
Cisapride	Cisapride The risk or severity of adverse effects can be increased when Cisapride is combined with Fentanyl.
Gabapentin	Gabapentin The risk or severity of adverse effects can be increased when Fentanyl is combined with Gabapentin.
Fluvastatin	Fluvastatin The metabolism of Fentanyl can be decreased when combined with Fluvastatin.
Venlafaxine	Venlafaxine The risk or severity of adverse effects can be increased when Venlafaxine is combined with Fentanyl.
Fluvoxamine	Fluvoxamine The metabolism of Fentanyl can be decreased when combined with Fluvoxamine.
Nefazodone	Nefazodone The metabolism of Fentanyl can be decreased when combined with Nefazodone.
Lamotrigine	Lamotrigine The risk or severity of adverse effects can be increased when Lamotrigine is combined with Fentanyl.
Losartan	Losartan The metabolism of Fentanyl can be decreased when combined with Losartan.
Valacyclovir	Valacyclovir Valaciclovir may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Tramadol	Tramadol The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Fentanyl.
Carboplatin Injection	Carboplatin Injection Carboplatin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Moexipril	Moexipril Fentanyl may decrease the antihypertensive activities of Moexipril.
Lansoprazole	Lansoprazole The metabolism of Fentanyl can be decreased when combined with Lansoprazole.
Ifosfamide Injection	Ifosfamide Injection The metabolism of Fentanyl can be decreased when combined with Ifosfamide.
Nicardipine	Nicardipine The metabolism of Fentanyl can be decreased when combined with Nicardipine.
Bupropion	Bupropion The risk or severity of seizure can be increased when Fentanyl is combined with Bupropion.
Ticlopidine	Ticlopidine Ticlopidine may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Saquinavir	Saquinavir The metabolism of Fentanyl can be decreased when combined with Saquinavir.
Metformin	Metformin Metformin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Nisoldipine	Nisoldipine Fentanyl may decrease the antihypertensive activities of Nisoldipine.
Lamivudine	Lamivudine Lamivudine may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Riluzole	Riluzole The risk or severity of adverse effects can be increased when Riluzole is combined with Fentanyl.
Acarbose	Acarbose Acarbose may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Gemcitabine Injection	Gemcitabine Injection Gemcitabine may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Indinavir	Indinavir The metabolism of Fentanyl can be decreased when combined with Indinavir.
Ritonavir	Ritonavir The metabolism of Fentanyl can be decreased when combined with Ritonavir.
Docetaxel Injection	Docetaxel Injection The metabolism of Fentanyl can be decreased when combined with Docetaxel.
Cidofovir Injection	Cidofovir Injection Cidofovir may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Meropenem Injection	Meropenem Injection Meropenem may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Clomipramine	Clomipramine The risk or severity of adverse effects can be increased when Fentanyl is combined with Clomipramine.
Zafirlukast	Zafirlukast The metabolism of Fentanyl can be decreased when combined with Zafirlukast.
Fosfomycin	Fosfomycin Fentanyl may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Mirtazapine	Mirtazapine The metabolism of Mirtazapine can be decreased when combined with Fentanyl.
Trandolapril	Trandolapril Fentanyl may decrease the antihypertensive activities of Trandolapril.
Topiramate	Topiramate The risk or severity of adverse effects can be increased when Topiramate is combined with Fentanyl.
Valsartan	Valsartan Fentanyl may decrease the antihypertensive activities of Valsartan.
Pramipexole	Pramipexole Fentanyl may increase the sedative activities of Pramipexole.
Donepezil	Donepezil The risk or severity of adverse effects can be increased when Fentanyl is combined with Donepezil.
Nelfinavir	Nelfinavir The metabolism of Fentanyl can be decreased when combined with Nelfinavir.
Carvedilol	Carvedilol Fentanyl may decrease the antihypertensive activities of Carvedilol.
Nilutamide	Nilutamide Nilutamide may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Flutamide	Flutamide The metabolism of Fentanyl can be decreased when combined with Flutamide.
Selegiline	Selegiline The risk or severity of adverse effects can be increased when Selegiline is combined with Fentanyl.
Bicalutamide	Bicalutamide The metabolism of Fentanyl can be decreased when combined with Bicalutamide.
Sertraline	Sertraline The risk or severity of serotonin syndrome can be increased when Fentanyl is combined with Sertraline.
Propafenone	Propafenone Fentanyl may increase the bradycardic activities of Propafenone.
Raloxifene	Raloxifene The metabolism of Fentanyl can be decreased when combined with Raloxifene.
Irbesartan	Irbesartan The metabolism of Fentanyl can be decreased when combined with Irbesartan.
Tamsulosin	Tamsulosin Tamsulosin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Ropinirole	Ropinirole Fentanyl may increase the sedative activities of Ropinirole.
Finasteride	Finasteride The metabolism of Finasteride can be decreased when combined with Fentanyl.
Quetiapine	Quetiapine The risk or severity of adverse effects can be increased when Quetiapine is combined with Fentanyl.
Cefepime Injection	Cefepime Injection Cefepime may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Cefprozil	Cefprozil Cefprozil may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Cefpodoxime	Cefpodoxime Cefpodoxime may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Cetirizine	Cetirizine The risk or severity of adverse effects can be increased when Cetirizine is combined with Fentanyl.
Paroxetine	Paroxetine The metabolism of Fentanyl can be decreased when combined with Paroxetine.
Tolcapone	Tolcapone The risk or severity of adverse effects can be increased when Tolcapone is combined with Fentanyl.
Citalopram	Citalopram The metabolism of Fentanyl can be decreased when combined with Citalopram.
Capecitabine	Capecitabine Fentanyl may decrease the excretion rate of Capecitabine which could result in a higher serum level.
Efavirenz	Efavirenz The metabolism of Fentanyl can be decreased when combined with Efavirenz.
Abacavir	Abacavir Fentanyl may decrease the excretion rate of Abacavir which could result in a higher serum level.
Sildenafil	Sildenafil The metabolism of Fentanyl can be decreased when combined with Sildenafil.
Celecoxib	Celecoxib Celecoxib may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Rosiglitazone	Rosiglitazone Rosiglitazone may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Tolterodine	Tolterodine The risk or severity of adverse effects can be increased when Tolterodine is combined with Fentanyl.
Thalidomide	Thalidomide Fentanyl may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Oseltamivir	Oseltamivir Oseltamivir may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Balsalazide	Balsalazide Fentanyl may decrease the excretion rate of Balsalazide which could result in a higher serum level.
Nateglinide	Nateglinide The metabolism of Fentanyl can be decreased when combined with Nateglinide.
Galantamine	Galantamine Galantamine may increase the bradycardic activities of Fentanyl.
Levetiracetam	Levetiracetam The risk or severity of adverse effects can be increased when Fentanyl is combined with Levetiracetam.
Rabeprazole	Rabeprazole The metabolism of Fentanyl can be decreased when combined with Rabeprazole.