Glasdegib

Generic name: Pronounced as (glas deg' ib)
Brand names
  • Daurismo®
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Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 01/15/2019

Glasdegib must not be taken by patients who are pregnant or who may become pregnant. There is a high risk that glasdegib will cause severe birth defects (physical problems that are present at birth) or death of the unborn baby.

If you are a female who can become pregnant, you must have a negative pregnancy test within 7 days before you start treatment with glasdegib. You will need to use effective birth control during you treatment with glasdegib and for at least 30 days after your final dose. Talk to your doctor about birth control options that will work for you.

If you are a male with a female partner who can become pregnant or who is pregnant, you should know glasdegib may be present in the semen and may cause harm to the unborn baby. Use a condom during your treatment with glasdegib and for at least 30 days after the final dose even if you have had a vasectomy (surgery to prevent sperm from leaving your body and causing pregnancy). Do not donate semen during your treatment and for at least 30 days after yourfinal dose.

If you have had unprotected sex, think that your birth control has failed, or think you or your female partner may be pregnant call your doctor right away.

Do not donate blood or blood products during your treatment with glasdegib and for at least 30 days after your last dose.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with glasdegib and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide.

Glasdegib is used along with cytarabine as a first treatment for acute myeloid leukemia (AML; a type of cancer that begins in the white blood cells) in people over 75 years of age, or in adults who have other medical conditions and can not be treated with other chemotherapy medications. Glasdegib is in a class of medications called hedgehog pathway inhibitors. It works by blocking the action of a protein that signals cancer cells to multiply. This helps stop or slow the spread of cancer cells.

Glasdegib comes as a tablet to take by mouth. It is usually given with or without food once a day for at least 6 months, or as long as your doctor recommends treatment. Take glasdegib at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take glasdegib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the tablets whole; do not split, chew, or crush them.

If you vomit after taking glasdegib, do not take another dose. Continue your regular dosing schedule.

Your doctor may need to interrupt your treatment, reduce your dose, or stop your treatment depending on your response to the medication and any side effects that you experience. Be sure to tell your doctor how you are feeling during your treatment with glasdegib.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking glasdegib,

  • tell your doctor and pharmacist if you are allergic to glasdegib, any other medications, or any of the ingredients in glasdegib tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.

  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: amiodarone (Nexterone, Pacerone), carbamazepine (Carbatrol, Equetro, Tegretol, others), chlorpromazine, cilostazol, citalopram (Celexa), clarithromycin, disopyramide (Norpace), dofetilide, donepezil (Aricept), dronedarone (Multaq), efavirenz (Sustiva, in Atripla, Symfi), escitalopram (Lexapro), flecainide (Tambocor), fluconazole (Diflucan), haloperidol (Haldol), ibutilide (Corvert), indinavir (Crixivan), itraconazole (Sporanox, Onmel), ketaconazole, methadone (Dolophine, Methadose), nefazodone, nelfinavir (Viracept), nevirapine (Viramune), ondansetron (Zofran, Zuplenz), phenobarbital, phenytoin (Dilantin, Phenytek), pimozide (Orap), pioglitazone (Actos, in Oseni, Duetact, Actoplus Met), procainamide, quinidine (in Nuedexta), rifabutin (Mycobutin), rifampin (Rifadin, Rimactane, in Rifater, Rifamate), ritonavir (Norvir, in Viekira Pak, Kaletra, Technivie), sotalol (Betapace, Sorine, Sotylize), and thioridazine. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with glasdegib, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

  • tell your doctor what herbal products you are taking, especially St. John's wort.

  • tell your doctor if you have or have ever had prolonged QT interval (a rare heart problem that may cause irregular heartbeat, fainting, or sudden death), heart failure (condition in which the heart cannot pump enough blood to other parts of the body), or low levels of magnesium or potassium in your blood.

  • tell your doctor if you are breast-feeding. You should not breast-feed during your treatment with glasdegib and for at least 30 days after your final dose.

  • you should know that this medication may decrease fertility in men. Talk to your doctor about the risks of taking glasdegib.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose as soon as you remember it. However, if it less than 12 hours until your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Glasdegib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • muscle spasms

    • muscle, bone or joint pain

    • extreme tiredness

    • nausea

    • vomiting

    • abdominal pain

    • constipation

    • pain or sores in your mouth or throat

    • decreased appetite

    • change in the way things taste

    • weight loss

    • headache

    • rash

    • swelling of hands or legs

    • hair loss

    • toothache

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

    • feeling faint, lightheaded, or dizzy; fast or irregular heartbeat

    • unusual bruising or bleeding

    • fever alone or along with chills, weakness. or other signs of infection

    • decreased urination

    • chest pain

  • Glasdegib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

  • nausea

  • vomiting

  • extreme tiredness

  • dizziness

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests such as electrocardiograms (EKG, test that records the electrical activity of the heart) and blood tests before and during therapy to make sure it is safe for you to take glasdegib and to check your body's response to the medication.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Moxifloxacin Moxifloxacin The risk or severity of QTc prolongation can be increased when Moxifloxacin is combined with Glasdegib.
Repaglinide Repaglinide The metabolism of Glasdegib can be decreased when combined with Repaglinide.
Montelukast Montelukast The metabolism of Glasdegib can be decreased when combined with Montelukast.
Leflunomide Leflunomide Glasdegib may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Atorvastatin Atorvastatin The metabolism of Glasdegib can be decreased when combined with Atorvastatin.
Dolasetron Dolasetron The risk or severity of QTc prolongation can be increased when Dolasetron is combined with Glasdegib.
Anagrelide Anagrelide The risk or severity of QTc prolongation can be increased when Anagrelide is combined with Glasdegib.
Candesartan Candesartan The metabolism of Glasdegib can be decreased when combined with Candesartan.
Cilostazol Cilostazol The risk or severity of QTc prolongation can be increased when Cilostazol is combined with Glasdegib.
Clopidogrel Clopidogrel The metabolism of Glasdegib can be decreased when combined with Clopidogrel.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The risk or severity of QTc prolongation can be increased when Erythromycin is combined with Glasdegib.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Glasdegib may decrease the excretion rate of Conjugated estrogens which could result in a higher serum level.
Fenofibrate Fenofibrate The metabolism of Glasdegib can be decreased when combined with Fenofibrate.
Paregoric Paregoric The serum concentration of Morphine can be increased when it is combined with Glasdegib.
Penbutolol Penbutolol The risk or severity of QTc prolongation can be increased when Acebutolol is combined with Glasdegib.
Reserpine Reserpine The serum concentration of Glasdegib can be increased when it is combined with Reserpine.
Sumatriptan Sumatriptan Glasdegib may decrease the excretion rate of Sumatriptan which could result in a higher serum level.
Tacrolimus Tacrolimus The serum concentration of Glasdegib can be increased when it is combined with Tacrolimus.
Tizanidine Tizanidine The risk or severity of QTc prolongation can be increased when Tizanidine is combined with Glasdegib.
Famotidine Injection Famotidine Injection The risk or severity of QTc prolongation can be increased when Famotidine is combined with Glasdegib.
Fluconazole Injection Fluconazole Injection The risk or severity of QTc prolongation can be increased when Fluconazole is combined with Glasdegib.
Foscarnet Injection Foscarnet Injection The risk or severity of QTc prolongation can be increased when Foscarnet is combined with Glasdegib.
Levofloxacin Injection Levofloxacin Injection The risk or severity of QTc prolongation can be increased when Levofloxacin is combined with Glasdegib.
Metoclopramide Injection Metoclopramide Injection The risk or severity of QTc prolongation can be increased when Metoclopramide is combined with Glasdegib.
Metronidazole Injection Metronidazole Injection The risk or severity of QTc prolongation can be increased when Metronidazole is combined with Glasdegib.
Morphine Injection Morphine Injection The serum concentration of Morphine can be increased when it is combined with Glasdegib.
Zidovudine Injection Zidovudine Injection Glasdegib may decrease the excretion rate of Zidovudine which could result in a higher serum level.
Cyclosporine Cyclosporine The serum concentration of Cyclosporine can be increased when it is combined with Glasdegib.
Ondansetron Ondansetron The risk or severity of QTc prolongation can be increased when Ondansetron is combined with Glasdegib.
Granisetron Granisetron The risk or severity of QTc prolongation can be increased when Granisetron is combined with Glasdegib.
Torsemide Torsemide The metabolism of Glasdegib can be decreased when combined with Torasemide.
Olanzapine Olanzapine The risk or severity of QTc prolongation can be increased when Olanzapine is combined with Glasdegib.
Dofetilide Dofetilide The risk or severity of QTc prolongation can be increased when Dofetilide is combined with Glasdegib.
Hydroxychloroquine Hydroxychloroquine The risk or severity of QTc prolongation can be increased when Hydroxychloroquine is combined with Glasdegib.
Pantoprazole Pantoprazole Pantoprazole may decrease the excretion rate of Glasdegib which could result in a higher serum level.
Telmisartan Telmisartan Telmisartan may decrease the excretion rate of Glasdegib which could result in a higher serum level.
Anakinra Anakinra The metabolism of Glasdegib can be increased when combined with Anakinra.
Desloratadine Desloratadine The risk or severity of QTc prolongation can be increased when Desloratadine is combined with Glasdegib.
Trimipramine Trimipramine The serum concentration of Glasdegib can be increased when it is combined with Trimipramine.
Etanercept Injection Etanercept Injection The metabolism of Glasdegib can be increased when combined with Etanercept.
Tenofovir Tenofovir The serum concentration of Tenofovir can be increased when it is combined with Glasdegib.
Sirolimus Sirolimus The serum concentration of Sirolimus can be increased when it is combined with Glasdegib.
Escitalopram Escitalopram The risk or severity of QTc prolongation can be increased when Escitalopram is combined with Glasdegib.
Zonisamide Zonisamide The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Glasdegib.
Adalimumab Injection Adalimumab Injection The metabolism of Glasdegib can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The risk or severity of QTc prolongation can be increased when Aripiprazole is combined with Glasdegib.
Atomoxetine Atomoxetine The risk or severity of QTc prolongation can be increased when Atomoxetine is combined with Glasdegib.
Ezetimibe Ezetimibe Glasdegib may decrease the excretion rate of Ezetimibe which could result in a higher serum level.
Atazanavir Atazanavir The risk or severity of QTc prolongation can be increased when Atazanavir is combined with Glasdegib.
Almotriptan Almotriptan The metabolism of Glasdegib can be decreased when combined with Almotriptan.
Mefloquine Mefloquine The risk or severity of QTc prolongation can be increased when Mefloquine is combined with Glasdegib.
Rosuvastatin Rosuvastatin Glasdegib may decrease the excretion rate of Rosuvastatin which could result in a higher serum level.
Vardenafil Vardenafil The serum concentration of Vardenafil can be increased when it is combined with Glasdegib.
Alfuzosin Alfuzosin The risk or severity of QTc prolongation can be increased when Alfuzosin is combined with Glasdegib.
Emtricitabine Emtricitabine The excretion of Emtricitabine can be decreased when combined with Glasdegib.
Tegaserod Tegaserod Glasdegib may decrease the excretion rate of Tegaserod which could result in a higher serum level.
Gemifloxacin Gemifloxacin The risk or severity of QTc prolongation can be increased when Gemifloxacin is combined with Glasdegib.
Progesterone Progesterone Progesterone may decrease the excretion rate of Glasdegib which could result in a higher serum level.
Apomorphine Injection Apomorphine Injection The risk or severity of QTc prolongation can be increased when Apomorphine is combined with Glasdegib.
Darbepoetin Alfa Injection Darbepoetin Alfa Injection The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Glasdegib.
Infliximab Injection Infliximab Injection The metabolism of Glasdegib can be increased when combined with Infliximab.
Protriptyline Protriptyline The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Glasdegib.
Rifaximin Rifaximin The serum concentration of Rifaximin can be increased when it is combined with Glasdegib.
Erlotinib Erlotinib The metabolism of Glasdegib can be decreased when combined with Erlotinib.
Eszopiclone Eszopiclone The metabolism of Glasdegib can be decreased when combined with Eszopiclone.
Ganciclovir Ganciclovir The excretion of Ganciclovir can be decreased when combined with Glasdegib.
Solifenacin Solifenacin The risk or severity of QTc prolongation can be increased when Solifenacin is combined with Glasdegib.
Voriconazole Voriconazole The risk or severity of QTc prolongation can be increased when Voriconazole is combined with Glasdegib.
Ibandronate Ibandronate The risk or severity of QTc prolongation can be increased when Ibandronate is combined with Glasdegib.
Pregabalin Pregabalin The risk or severity of QTc prolongation can be increased when Pregabalin is combined with Glasdegib.
Deferasirox Deferasirox The metabolism of Glasdegib can be decreased when combined with Deferasirox.
Tipranavir Tipranavir The serum concentration of Tipranavir can be increased when it is combined with Glasdegib.
Felbamate Felbamate The risk or severity of QTc prolongation can be increased when Felbamate is combined with Glasdegib.
Ranolazine Ranolazine The serum concentration of Glasdegib can be increased when it is combined with Ranolazine.
Abatacept Injection Abatacept Injection The metabolism of Glasdegib can be increased when combined with Abatacept.
Imatinib Imatinib The risk or severity of QTc prolongation can be increased when Imatinib is combined with Glasdegib.
Sitagliptin Sitagliptin The serum concentration of Sitagliptin can be increased when it is combined with Glasdegib.
Gefitinib Gefitinib Gefitinib may decrease the excretion rate of Glasdegib which could result in a higher serum level.
Albuterol Albuterol The risk or severity of QTc prolongation can be increased when Salbutamol is combined with Glasdegib.
Paliperidone Paliperidone The risk or severity of QTc prolongation can be increased when Paliperidone is combined with Glasdegib.
Bortezomib Bortezomib The serum concentration of Glasdegib can be increased when it is combined with Bortezomib.
Clofarabine Injection Clofarabine Injection Glasdegib may decrease the excretion rate of Clofarabine which could result in a higher serum level.
Oxaliplatin Injection Oxaliplatin Injection The risk or severity of QTc prolongation can be increased when Oxaliplatin is combined with Glasdegib.
Posaconazole Posaconazole The risk or severity of QTc prolongation can be increased when Posaconazole is combined with Glasdegib.
Primaquine Primaquine The risk or severity of QTc prolongation can be increased when Primaquine is combined with Glasdegib.
Dimenhydrinate Dimenhydrinate The risk or severity of QTc prolongation can be increased when Dimenhydrinate is combined with Glasdegib.
Nabilone Nabilone The metabolism of Glasdegib can be decreased when combined with Nabilone.
Vorinostat Vorinostat The risk or severity of QTc prolongation can be increased when Vorinostat is combined with Glasdegib.
Sorafenib Sorafenib The metabolism of Glasdegib can be decreased when combined with Sorafenib.
Sunitinib Sunitinib The risk or severity of QTc prolongation can be increased when Sunitinib is combined with Glasdegib.
Dronabinol Dronabinol Dronabinol may decrease the excretion rate of Glasdegib which could result in a higher serum level.
Lapatinib Lapatinib The risk or severity of QTc prolongation can be increased when Lapatinib is combined with Glasdegib.
Levocetirizine Levocetirizine The risk or severity of QTc prolongation can be increased when Levocetirizine is combined with Glasdegib.
Dasatinib Dasatinib The serum concentration of Dasatinib can be increased when it is combined with Glasdegib.
Ivermectin Ivermectin Glasdegib may decrease the excretion rate of Ivermectin which could result in a higher serum level.
Temsirolimus Temsirolimus The serum concentration of Temsirolimus can be increased when it is combined with Glasdegib.
Nilotinib Nilotinib The risk or severity of QTc prolongation can be increased when Nilotinib is combined with Glasdegib.
Toremifene Toremifene The risk or severity of QTc prolongation can be increased when Toremifene is combined with Glasdegib.
Bexarotene Bexarotene The metabolism of Glasdegib can be decreased when combined with Bexarotene.
Arsenic Trioxide Injection Arsenic Trioxide Injection The risk or severity of QTc prolongation can be increased when Arsenic trioxide is combined with Glasdegib.
Mitoxantrone Injection Mitoxantrone Injection Glasdegib may decrease the excretion rate of Mitoxantrone which could result in a higher serum level.
Tretinoin Tretinoin The metabolism of Glasdegib can be decreased when combined with Tretinoin.
Bendamustine Injection Bendamustine Injection The serum concentration of Bendamustine can be increased when it is combined with Glasdegib.
Flecainide Flecainide The risk or severity of QTc prolongation can be increased when Flecainide is combined with Glasdegib.
Certolizumab Injection Certolizumab Injection The metabolism of Glasdegib can be increased when combined with Certolizumab pegol.
Irinotecan Injection Irinotecan Injection Glasdegib may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Silodosin Silodosin The serum concentration of Silodosin can be increased when it is combined with Glasdegib.
Eltrombopag Eltrombopag The metabolism of Glasdegib can be decreased when combined with Eltrombopag.
Degarelix Injection Degarelix Injection The risk or severity of QTc prolongation can be increased when Degarelix is combined with Glasdegib.
Betaxolol Betaxolol The risk or severity of QTc prolongation can be increased when Betaxolol is combined with Glasdegib.
Iloperidone Iloperidone The risk or severity of QTc prolongation can be increased when Iloperidone is combined with Glasdegib.
Everolimus Everolimus The serum concentration of Everolimus can be increased when it is combined with Glasdegib.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The serum concentration of Tolvaptan can be increased when it is combined with Glasdegib.
Dronedarone Dronedarone Glasdegib may increase the QTc-prolonging activities of Dronedarone.
Pralatrexate Injection Pralatrexate Injection Glasdegib may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Telavancin Injection Telavancin Injection The risk or severity of QTc prolongation can be increased when Telavancin is combined with Glasdegib.
Romidepsin Injection Romidepsin Injection The serum concentration of Glasdegib can be increased when it is combined with Romidepsin.
Topotecan Topotecan The serum concentration of Topotecan can be increased when it is combined with Glasdegib.
Golimumab Injection Golimumab Injection The metabolism of Glasdegib can be increased when combined with Golimumab.
Pazopanib Pazopanib The serum concentration of Pazopanib can be increased when it is combined with Glasdegib.
Asenapine Asenapine The risk or severity of QTc prolongation can be increased when Asenapine is combined with Glasdegib.
Pitavastatin Pitavastatin Glasdegib may decrease the excretion rate of Pitavastatin which could result in a higher serum level.
Tocilizumab Injection Tocilizumab Injection The metabolism of Glasdegib can be increased when combined with Tocilizumab.
Eribulin Injection Eribulin Injection The risk or severity of QTc prolongation can be increased when Eribulin is combined with Glasdegib.
Cabazitaxel Injection Cabazitaxel Injection The serum concentration of Glasdegib can be increased when it is combined with Cabazitaxel.
Lurasidone Lurasidone The risk or severity of QTc prolongation can be increased when Lurasidone is combined with Glasdegib.
Terbutaline Injection Terbutaline Injection The risk or severity of QTc prolongation can be increased when Terbutaline is combined with Glasdegib.
Linagliptin Linagliptin The serum concentration of Glasdegib can be increased when it is combined with Linagliptin.
Rilpivirine Rilpivirine Rilpivirine may decrease the excretion rate of Glasdegib which could result in a higher serum level.
Telaprevir Telaprevir Glasdegib may decrease the excretion rate of Glecaprevir which could result in a higher serum level.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Glasdegib can be increased when combined with Cyclophosphamide.
Abiraterone Abiraterone The metabolism of Glasdegib can be decreased when combined with Abiraterone.
Triptorelin Injection Triptorelin Injection The risk or severity of QTc prolongation can be increased when Triptorelin is combined with Glasdegib.
Rivaroxaban Rivaroxaban The serum concentration of Rivaroxaban can be increased when it is combined with Glasdegib.
Ticagrelor Ticagrelor The serum concentration of Ticagrelor can be increased when it is combined with Glasdegib.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The serum concentration of Brentuximab vedotin can be increased when it is combined with Glasdegib.
Vandetanib Vandetanib The risk or severity of QTc prolongation can be increased when Vandetanib is combined with Glasdegib.
Clobazam Clobazam The serum concentration of Clobazam can be increased when it is combined with Glasdegib.
Vemurafenib Vemurafenib The serum concentration of Glasdegib can be increased when it is combined with Vemurafenib.
Vismodegib Vismodegib Vismodegib may decrease the excretion rate of Glasdegib which could result in a higher serum level.
Ivacaftor Ivacaftor The serum concentration of Glasdegib can be increased when it is combined with Ivacaftor.
Axitinib Axitinib The serum concentration of Axitinib can be increased when it is combined with Glasdegib.
Crizotinib Crizotinib The serum concentration of Glasdegib can be increased when it is combined with Crizotinib.
Cabergoline Cabergoline The serum concentration of Cabergoline can be increased when it is combined with Glasdegib.
Ambrisentan Ambrisentan The serum concentration of Ambrisentan can be increased when it is combined with Glasdegib.
Carfilzomib Injection Carfilzomib Injection The serum concentration of Carfilzomib can be increased when it is combined with Glasdegib.
Enzalutamide Enzalutamide The serum concentration of Glasdegib can be increased when it is combined with Enzalutamide.
Mirabegron Mirabegron The risk or severity of QTc prolongation can be increased when Mirabegron is combined with Glasdegib.
Regorafenib Regorafenib The serum concentration of Glasdegib can be increased when it is combined with Regorafenib.
Bosutinib Bosutinib The serum concentration of Bosutinib can be increased when it is combined with Glasdegib.
Teriflunomide Teriflunomide The metabolism of Glasdegib can be decreased when combined with Teriflunomide.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Glasdegib can be decreased when combined with Cabozantinib.
Bedaquiline Bedaquiline The risk or severity of QTc prolongation can be increased when Bedaquiline is combined with Glasdegib.
Ponatinib Ponatinib The metabolism of Glasdegib can be decreased when combined with Ponatinib.
Pomalidomide Pomalidomide The serum concentration of Pomalidomide can be increased when it is combined with Glasdegib.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The serum concentration of Trastuzumab emtansine can be increased when it is combined with Glasdegib.
Apixaban Apixaban Glasdegib may decrease the excretion rate of Apixaban which could result in a higher serum level.
Canagliflozin Canagliflozin The serum concentration of Glasdegib can be increased when it is combined with Canagliflozin.
Dabrafenib Dabrafenib The serum concentration of Glasdegib can be increased when it is combined with Dabrafenib.
Trametinib Trametinib The metabolism of Glasdegib can be decreased when combined with Trametinib.
Dolutegravir Dolutegravir Glasdegib may decrease the excretion rate of Dolutegravir which could result in a higher serum level.
Afatinib Afatinib The serum concentration of Afatinib can be increased when it is combined with Glasdegib.
Levomilnacipran Levomilnacipran The metabolism of Glasdegib can be decreased when combined with Levomilnacipran.
Vortioxetine Vortioxetine The metabolism of Glasdegib can be decreased when combined with Vortioxetine.
Lomitapide Lomitapide The serum concentration of Lomitapide can be increased when it is combined with Glasdegib.
Ketorolac Injection Ketorolac Injection The metabolism of Glasdegib can be decreased when combined with Ketorolac.
Simeprevir Simeprevir The serum concentration of Glasdegib can be increased when it is combined with Simeprevir.
Sofosbuvir Sofosbuvir Glasdegib may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Apremilast Apremilast The metabolism of Glasdegib can be increased when combined with Apremilast.
Ceritinib Ceritinib The serum concentration of Glasdegib can be increased when it is combined with Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Glasdegib can be increased when combined with Siltuximab.
Belinostat Injection Belinostat Injection The serum concentration of Belinostat can be increased when it is combined with Glasdegib.
Idelalisib Idelalisib The serum concentration of Glasdegib can be increased when it is combined with Idelalisib.
Testosterone Injection Testosterone Injection Glasdegib may decrease the excretion rate of Testosterone which could result in a higher serum level.
Vorapaxar Vorapaxar The serum concentration of Glasdegib can be increased when it is combined with Vorapaxar.
Suvorexant Suvorexant The serum concentration of Glasdegib can be increased when it is combined with Suvorexant.
Edoxaban Edoxaban The serum concentration of Edoxaban can be increased when it is combined with Glasdegib.
Olaparib Olaparib Olaparib may decrease the excretion rate of Glasdegib which could result in a higher serum level.
Riociguat Riociguat Glasdegib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Nintedanib Nintedanib The serum concentration of Nintedanib can be increased when it is combined with Glasdegib.
Secukinumab Injection Secukinumab Injection The metabolism of Glasdegib can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The risk or severity of QTc prolongation can be increased when Risperidone is combined with Glasdegib.
Palbociclib Palbociclib Palbociclib may decrease the excretion rate of Glasdegib which could result in a higher serum level.
Lenvatinib Lenvatinib The risk or severity of QTc prolongation can be increased when Lenvatinib is combined with Glasdegib.
Naloxegol Naloxegol The serum concentration of Naloxegol can be increased when it is combined with Glasdegib.
Panobinostat Panobinostat The serum concentration of Glasdegib can be increased when it is combined with Panobinostat.
Haloperidol Injection Haloperidol Injection The risk or severity of QTc prolongation can be increased when Haloperidol is combined with Glasdegib.
Ivabradine Ivabradine The risk or severity of QTc prolongation can be increased when Ivabradine is combined with Glasdegib.
Isavuconazonium Injection Isavuconazonium Injection The serum concentration of Glasdegib can be increased when it is combined with Isavuconazonium.
Flibanserin Flibanserin The serum concentration of Glasdegib can be increased when it is combined with Flibanserin.
Rolapitant Rolapitant Rolapitant may decrease the excretion rate of Glasdegib which could result in a higher serum level.
Daclatasvir Daclatasvir Daclatasvir may decrease the excretion rate of Glasdegib which could result in a higher serum level.
Ziprasidone Injection Ziprasidone Injection The risk or severity of QTc prolongation can be increased when Ziprasidone is combined with Glasdegib.
Cobimetinib Cobimetinib The serum concentration of Cobimetinib can be increased when it is combined with Glasdegib.
Osimertinib Osimertinib The serum concentration of Osimertinib can be increased when it is combined with Glasdegib.
Alectinib Alectinib Alectinib may decrease the excretion rate of Glasdegib which could result in a higher serum level.
Rifapentine Rifapentine The metabolism of Glasdegib can be increased when combined with Rifapentine.
Dexamethasone Injection Dexamethasone Injection Dexamethasone may decrease the excretion rate of Glasdegib which could result in a higher serum level.
Venetoclax Venetoclax The serum concentration of Glasdegib can be increased when it is combined with Venetoclax.
Cobicistat Cobicistat The serum concentration of Glasdegib can be increased when it is combined with Cobicistat.
Selexipag Selexipag The serum concentration of Selexipag can be increased when it is combined with Glasdegib.
Diphenhydramine Injection Diphenhydramine Injection The risk or severity of QTc prolongation can be increased when Diphenhydramine is combined with Glasdegib.
Rucaparib Rucaparib Glasdegib may decrease the excretion rate of Rucaparib which could result in a higher serum level.
Ribociclib Ribociclib The risk or severity of QTc prolongation can be increased when Ribociclib is combined with Glasdegib.
Brigatinib Brigatinib The metabolism of Brigatinib can be decreased when combined with Glasdegib.
Doxepin (Insomnia) Doxepin (Insomnia) The risk or severity of QTc prolongation can be increased when Doxepin is combined with Glasdegib.
Deutetrabenazine Deutetrabenazine The risk or severity of QTc prolongation can be increased when Glasdegib is combined with Deutetrabenazine.
Safinamide Safinamide Safinamide may decrease the excretion rate of Glasdegib which could result in a higher serum level.
Midostaurin Midostaurin The metabolism of Glasdegib can be decreased when combined with Midostaurin.
Neratinib Neratinib The serum concentration of Glasdegib can be increased when it is combined with Neratinib.
Enasidenib Enasidenib The metabolism of Glasdegib can be decreased when combined with Enasidenib.
Inotuzumab Ozogamicin Injection Inotuzumab Ozogamicin Injection The serum concentration of Inotuzumab ozogamicin can be increased when it is combined with Glasdegib.
Copanlisib Injection Copanlisib Injection The serum concentration of Copanlisib can be increased when it is combined with Glasdegib.
Delafloxacin Delafloxacin The risk or severity of QTc prolongation can be increased when Delafloxacin is combined with Glasdegib.
Abemaciclib Abemaciclib The serum concentration of Abemaciclib can be increased when it is combined with Glasdegib.
Betrixaban Betrixaban The serum concentration of Betrixaban can be increased when it is combined with Glasdegib.
Letermovir Letermovir Letermovir may decrease the excretion rate of Glasdegib which could result in a higher serum level.
Tetrabenazine Tetrabenazine The risk or severity of QTc prolongation can be increased when Tetrabenazine is combined with Glasdegib.
Ertugliflozin Ertugliflozin Glasdegib may decrease the excretion rate of Ertugliflozin which could result in a higher serum level.
Buprenorphine Injection Buprenorphine Injection Buprenorphine may decrease the excretion rate of Glasdegib which could result in a higher serum level.
Apalutamide Apalutamide The serum concentration of Glasdegib can be decreased when it is combined with Apalutamide.
Fostamatinib Fostamatinib Fostamatinib may decrease the excretion rate of Glasdegib which could result in a higher serum level.
Avatrombopag Avatrombopag Avatrombopag may decrease the excretion rate of Glasdegib which could result in a higher serum level.
Baricitinib Baricitinib The excretion of Baricitinib can be decreased when combined with Glasdegib.
Lofexidine Lofexidine The risk or severity of QTc prolongation can be increased when Lofexidine is combined with Glasdegib.
Eliglustat Eliglustat The risk or severity of QTc prolongation can be increased when Glasdegib is combined with Eliglustat.
Encorafenib Encorafenib The risk or severity of QTc prolongation can be increased when Encorafenib is combined with Glasdegib.
Binimetinib Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Glasdegib.
Ivosidenib Ivosidenib The risk or severity of QTc prolongation can be increased when Ivosidenib is combined with Glasdegib.
Lusutrombopag Lusutrombopag Glasdegib may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Elagolix Elagolix The serum concentration of Elagolix can be increased when it is combined with Glasdegib.
Cannabidiol Cannabidiol Cannabidiol may decrease the excretion rate of Glasdegib which could result in a higher serum level.
Dacomitinib Dacomitinib The serum concentration of Glasdegib can be increased when it is combined with Dacomitinib.
Duvelisib Duvelisib Glasdegib may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Omadacycline Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Glasdegib.
Sarecycline Sarecycline The serum concentration of Glasdegib can be increased when it is combined with Sarecycline.
Talazoparib Talazoparib The serum concentration of Talazoparib can be increased when it is combined with Glasdegib.
Gilteritinib Gilteritinib The risk or severity of QTc prolongation can be increased when Gilteritinib is combined with Glasdegib.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Glasdegib.
Larotrectinib Larotrectinib The serum concentration of Larotrectinib can be increased when it is combined with Glasdegib.
Methoxy Polyethylene Glycol-Epoetin Beta Injection Methoxy Polyethylene Glycol-Epoetin Beta Injection The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Glasdegib.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Glasdegib can be decreased when combined with Paclitaxel.
Rifamycin Rifamycin The serum concentration of Glasdegib can be increased when it is combined with Rifamycin.
Prucalopride Prucalopride The serum concentration of Prucalopride can be increased when it is combined with Glasdegib.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Glasdegib can be increased when combined with Emapalumab.
Acyclovir Ophthalmic Acyclovir Ophthalmic The excretion of Acyclovir can be decreased when combined with Glasdegib.
Erdafitinib Erdafitinib The serum concentration of Glasdegib can be increased when it is combined with Erdafitinib.
Alpelisib Alpelisib The serum concentration of Alpelisib can be increased when it is combined with Glasdegib.
Cladribine Cladribine Glasdegib may decrease the excretion rate of Cladribine which could result in a higher serum level.
Solriamfetol Solriamfetol The excretion of Solriamfetol can be decreased when combined with Glasdegib.
Darolutamide Darolutamide The serum concentration of Darolutamide can be increased when it is combined with Glasdegib.
Triclabendazole Triclabendazole The risk or severity of QTc prolongation can be increased when Triclabendazole is combined with Glasdegib.
Entrectinib Entrectinib The risk or severity of QTc prolongation can be increased when Glasdegib is combined with Entrectinib.
Istradefylline Istradefylline The metabolism of Glasdegib can be decreased when combined with Istradefylline.
Pitolisant Pitolisant The serum concentration of Glasdegib can be decreased when it is combined with Pitolisant.
Fedratinib Fedratinib Fedratinib may decrease the excretion rate of Glasdegib which could result in a higher serum level.
Lefamulin Lefamulin Glasdegib may increase the QTc-prolonging activities of Lefamulin.
Phenytoin Injection Phenytoin Injection The metabolism of Glasdegib can be decreased when combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Glasdegib can be decreased when combined with Fosphenytoin.
Enfortumab vedotin-ejfv Injection Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be increased when it is combined with Glasdegib.
Lasmiditan Lasmiditan The serum concentration of Glasdegib can be increased when it is combined with Lasmiditan.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Glasdegib.
Tazemetostat Tazemetostat Glasdegib may decrease the excretion rate of Tazemetostat which could result in a higher serum level.
Cenobamate Cenobamate The serum concentration of Glasdegib can be decreased when it is combined with Cenobamate.
Ozanimod Ozanimod Glasdegib may decrease the excretion rate of Ozanimod which could result in a higher serum level.
Selumetinib Selumetinib Glasdegib may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Rimegepant Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Glasdegib.
Tucatinib Tucatinib Glasdegib may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Remdesivir Injection Remdesivir Injection The serum concentration of Remdesivir can be increased when it is combined with Glasdegib.
Ripretinib Ripretinib Glasdegib may decrease the excretion rate of Ripretinib which could result in a higher serum level.
Selpercatinib Selpercatinib The serum concentration of Glasdegib can be increased when it is combined with Selpercatinib.
Capmatinib Capmatinib The serum concentration of Glasdegib can be increased when it is combined with Capmatinib.
Lemborexant Lemborexant The serum concentration of Lemborexant can be increased when it is combined with Glasdegib.
Fostemsavir Fostemsavir The risk or severity of QTc prolongation can be increased when Fostemsavir is combined with Glasdegib.
Octreotide Octreotide The risk or severity of QTc prolongation can be increased when Octreotide is combined with Glasdegib.
Belantamab Mafodotin-blmf Injection Belantamab Mafodotin-blmf Injection The serum concentration of Belantamab mafodotin can be increased when it is combined with Glasdegib.
Pralsetinib Pralsetinib The serum concentration of Pralsetinib can be increased when it is combined with Glasdegib.
Opicapone Opicapone The metabolism of Glasdegib can be decreased when combined with Opicapone.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Glasdegib can be decreased when it is combined with Satralizumab.
Relugolix Relugolix The serum concentration of Relugolix can be increased when it is combined with Glasdegib.
Theophylline Theophylline The metabolism of Glasdegib can be decreased when combined with Theophylline.
Mefenamic Acid Mefenamic Acid The metabolism of Glasdegib can be decreased when combined with Mefenamic acid.
Naproxen Naproxen The metabolism of Glasdegib can be decreased when combined with Naproxen.
Trazodone Trazodone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Glasdegib.
Phenobarbital Phenobarbital The metabolism of Glasdegib can be increased when combined with Phenobarbital.
Methotrexate Injection Methotrexate Injection Glasdegib may decrease the excretion rate of Methotrexate which could result in a higher serum level.
Methsuximide Methsuximide The risk or severity of QTc prolongation can be increased when Methsuximide is combined with Glasdegib.
Chlorpromazine Chlorpromazine The risk or severity of QTc prolongation can be increased when Chlorpromazine is combined with Glasdegib.
Amantadine Amantadine The risk or severity of QTc prolongation can be increased when Amantadine is combined with Glasdegib.
Phenelzine Phenelzine The metabolism of Glasdegib can be decreased when combined with Phenelzine.
Prochlorperazine Prochlorperazine The risk or severity of QTc prolongation can be increased when Prochlorperazine is combined with Glasdegib.
Thioridazine Thioridazine The risk or severity of QTc prolongation can be increased when Thioridazine is combined with Glasdegib.
Dapsone Dapsone The metabolism of Glasdegib can be decreased when combined with Dapsone.
Sulfadiazine Sulfadiazine The metabolism of Glasdegib can be decreased when combined with Sulfadiazine.
Methadone Methadone The risk or severity of QTc prolongation can be increased when Methadone is combined with Glasdegib.
Oxybutynin Oxybutynin The metabolism of Glasdegib can be decreased when combined with Oxybutynin.
Benztropine Benztropine The risk or severity of QTc prolongation can be increased when Benzatropine is combined with Glasdegib.
Maprotiline Maprotiline The risk or severity of QTc prolongation can be increased when Maprotiline is combined with Glasdegib.
Ibuprofen Ibuprofen The metabolism of Glasdegib can be decreased when combined with Ibuprofen.
Orphenadrine Orphenadrine The risk or severity of QTc prolongation can be increased when Orphenadrine is combined with Glasdegib.
Amoxapine Amoxapine The risk or severity of QTc prolongation can be increased when Amoxapine is combined with Glasdegib.
Sulfasalazine Sulfasalazine Sulfasalazine may decrease the excretion rate of Glasdegib which could result in a higher serum level.
Hydrocortisone Hydrocortisone The metabolism of Glasdegib can be increased when combined with Hydrocortisone.
Doxorubicin Doxorubicin The serum concentration of Doxorubicin can be increased when it is combined with Glasdegib.
Dactinomycin Dactinomycin The serum concentration of Dactinomycin can be increased when it is combined with Glasdegib.
Prazosin Prazosin Glasdegib may decrease the excretion rate of Prazosin which could result in a higher serum level.
Cimetidine Cimetidine The excretion of Cimetidine can be decreased when combined with Glasdegib.
Warfarin Warfarin The metabolism of Glasdegib can be decreased when combined with Warfarin.
Loperamide Loperamide The risk or severity of QTc prolongation can be increased when Loperamide is combined with Glasdegib.
Promethazine Promethazine The risk or severity of QTc prolongation can be increased when Promethazine is combined with Glasdegib.
Daunorubicin Daunorubicin Glasdegib may decrease the excretion rate of Daunorubicin which could result in a higher serum level.
Nitrofurantoin Nitrofurantoin Glasdegib may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Griseofulvin Griseofulvin The metabolism of Glasdegib can be increased when combined with Griseofulvin.
Digoxin Digoxin Glasdegib may decrease the excretion rate of Digoxin which could result in a higher serum level.
Loxapine Loxapine The serum concentration of Glasdegib can be increased when it is combined with Loxapine.
Chloroquine Chloroquine The risk or severity of QTc prolongation can be increased when Chloroquine is combined with Glasdegib.
Quinine Quinine The risk or severity of QTc prolongation can be increased when Quinine is combined with Glasdegib.
Ethosuximide Ethosuximide The risk or severity of QTc prolongation can be increased when Ethosuximide is combined with Glasdegib.
Sulfinpyrazone Sulfinpyrazone The metabolism of Glasdegib can be decreased when combined with Sulfinpyrazone.
Secobarbital Secobarbital The metabolism of Glasdegib can be increased when combined with Secobarbital.
Desipramine Desipramine The risk or severity of QTc prolongation can be increased when Desipramine is combined with Glasdegib.
Amitriptyline Amitriptyline The risk or severity of QTc prolongation can be increased when Amitriptyline is combined with Glasdegib.
Imipramine Imipramine The serum concentration of Glasdegib can be increased when it is combined with Imipramine.
Probenecid Probenecid The metabolism of Glasdegib can be increased when combined with Probenecid.
Quinidine Quinidine The serum concentration of Quinidine can be increased when it is combined with Glasdegib.
Procainamide Procainamide The risk or severity of QTc prolongation can be increased when Procainamide is combined with Glasdegib.
Rifampin Rifampin The metabolism of Glasdegib can be increased when combined with Rifampicin.
Disopyramide Disopyramide The risk or severity of QTc prolongation can be increased when Disopyramide is combined with Glasdegib.
Valproic Acid Valproic Acid The risk or severity of QTc prolongation can be increased when Valproic acid is combined with Glasdegib.
Tamoxifen Tamoxifen The risk or severity of QTc prolongation can be increased when Tamoxifen is combined with Glasdegib.
Levothyroxine Levothyroxine The metabolism of Glasdegib can be decreased when combined with Levothyroxine.
Tolbutamide Tolbutamide The metabolism of Glasdegib can be decreased when combined with Tolbutamide.
Doxylamine Doxylamine The risk or severity of QTc prolongation can be increased when Doxylamine is combined with Glasdegib.
Cyproheptadine Cyproheptadine The risk or severity of QTc prolongation can be increased when Cyproheptadine is combined with Glasdegib.
Clemastine Clemastine The risk or severity of QTc prolongation can be increased when Clemastine is combined with Glasdegib.
Chlorpheniramine Chlorpheniramine The risk or severity of QTc prolongation can be increased when Chlorpheniramine is combined with Glasdegib.
Brompheniramine Brompheniramine The risk or severity of QTc prolongation can be increased when Dexbrompheniramine is combined with Glasdegib.
Hydrochlorothiazide Hydrochlorothiazide The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Glasdegib.
Folic Acid Folic Acid Glasdegib may decrease the excretion rate of Folic acid which could result in a higher serum level.
Disulfiram Disulfiram The risk or severity of QTc prolongation can be increased when Disulfiram is combined with Glasdegib.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The risk or severity of QTc prolongation can be increased when Propranolol is combined with Glasdegib.
Nortriptyline Nortriptyline The serum concentration of Glasdegib can be increased when it is combined with Nortriptyline.
Spironolactone Spironolactone The metabolism of Glasdegib can be decreased when combined with Spironolactone.
Nadolol Nadolol The excretion of Nadolol can be decreased when combined with Glasdegib.
Allopurinol Allopurinol Glasdegib may decrease the excretion rate of Allopurinol which could result in a higher serum level.
Oxytocin Injection Oxytocin Injection The risk or severity of QTc prolongation can be increased when Oxytocin is combined with Glasdegib.
Clomiphene Clomiphene The serum concentration of Clomifene can be increased when it is combined with Glasdegib.
Papaverine Papaverine The risk or severity of QTc prolongation can be increased when Papaverine is combined with Glasdegib.
Fluorouracil Injection Fluorouracil Injection The metabolism of Glasdegib can be decreased when combined with Fluorouracil.
Colchicine Colchicine The serum concentration of Colchicine can be increased when it is combined with Glasdegib.
Cephalexin Cephalexin The excretion of Cephalexin can be decreased when combined with Glasdegib.
Ketoconazole Ketoconazole The risk or severity of QTc prolongation can be increased when Ketoconazole is combined with Glasdegib.
Vincristine Injection Vincristine Injection The excretion of Vincristine can be decreased when combined with Glasdegib.
Vinblastine Vinblastine The serum concentration of Glasdegib can be increased when it is combined with Vinblastine.
Hydroxyzine Hydroxyzine The risk or severity of QTc prolongation can be increased when Hydroxyzine is combined with Glasdegib.
Thiothixene Thiothixene The risk or severity of QTc prolongation can be increased when Thiothixene is combined with Glasdegib.
Hyoscyamine Hyoscyamine The risk or severity of QTc prolongation can be increased when Hyoscyamine is combined with Glasdegib.
Trimethoprim Trimethoprim The metabolism of Glasdegib can be decreased when combined with Trimethoprim.
Diltiazem Diltiazem The risk or severity of QTc prolongation can be increased when Diltiazem is combined with Glasdegib.
Nifedipine Nifedipine The risk or severity of QTc prolongation can be increased when Nifedipine is combined with Glasdegib.
Timolol Timolol The risk or severity of QTc prolongation can be increased when Timolol is combined with Glasdegib.
Verapamil Verapamil The metabolism of Glasdegib can be decreased when combined with Verapamil.
Diflunisal Diflunisal The metabolism of Glasdegib can be decreased when combined with Diflunisal.
Piroxicam Piroxicam The metabolism of Glasdegib can be decreased when combined with Piroxicam.
Etoposide Etoposide The serum concentration of Glasdegib can be increased when it is combined with Etoposide.
Glyburide Glyburide Glasdegib may decrease the excretion rate of Glyburide which could result in a higher serum level.
Indapamide Indapamide The risk or severity of QTc prolongation can be increased when Indapamide is combined with Glasdegib.
Pentamidine Injection Pentamidine Injection The risk or severity of QTc prolongation can be increased when Pentamidine is combined with Glasdegib.
Leuprolide Injection Leuprolide Injection The risk or severity of QTc prolongation can be increased when Leuprolide is combined with Glasdegib.
Gemfibrozil Gemfibrozil The metabolism of Glasdegib can be decreased when combined with Gemfibrozil.
Ketoprofen Ketoprofen The metabolism of Glasdegib can be decreased when combined with Ketoprofen.
Pimozide Pimozide The risk or severity of QTc prolongation can be increased when Glasdegib is combined with Pimozide.
Amiodarone Amiodarone The metabolism of Amiodarone can be decreased when combined with Glasdegib.
Lovastatin Lovastatin The metabolism of Glasdegib can be decreased when combined with Lovastatin.
Ciprofloxacin Ciprofloxacin The risk or severity of QTc prolongation can be increased when Ciprofloxacin is combined with Glasdegib.
Diclofenac Diclofenac The metabolism of Glasdegib can be decreased when combined with Diclofenac.
Fluoxetine Fluoxetine The risk or severity of QTc prolongation can be increased when Fluoxetine is combined with Glasdegib.
Nimodipine Nimodipine The risk or severity of QTc prolongation can be increased when Nimodipine is combined with Glasdegib.
Clozapine Clozapine The risk or severity of QTc prolongation can be increased when Clozapine is combined with Glasdegib.
Ofloxacin Ofloxacin The risk or severity of QTc prolongation can be increased when Ofloxacin is combined with Glasdegib.
Clarithromycin Clarithromycin The risk or severity of QTc prolongation can be increased when Clarithromycin is combined with Glasdegib.
Felodipine Felodipine The metabolism of Felodipine can be decreased when combined with Glasdegib.
Pravastatin Pravastatin Pravastatin may decrease the excretion rate of Glasdegib which could result in a higher serum level.
Simvastatin Simvastatin The serum concentration of Simvastatin can be increased when it is combined with Glasdegib.
Epoetin Alfa, Injection Epoetin Alfa, Injection The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Glasdegib.
Teniposide Injection Teniposide Injection Glasdegib may decrease the excretion rate of Teniposide which could result in a higher serum level.
Itraconazole Itraconazole The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Glasdegib.
Rifabutin Rifabutin The metabolism of Glasdegib can be increased when combined with Rifabutin.
Sotalol Sotalol The risk or severity of QTc prolongation can be increased when Sotalol is combined with Glasdegib.
Bisoprolol Bisoprolol The serum concentration of Glasdegib can be increased when it is combined with Bisoprolol.
Isradipine Isradipine The risk or severity of QTc prolongation can be increased when Isradipine is combined with Glasdegib.
Omeprazole Omeprazole Omeprazole may decrease the excretion rate of Glasdegib which could result in a higher serum level.
Cisapride Cisapride The risk or severity of QTc prolongation can be increased when Cisapride is combined with Glasdegib.
Fluvastatin Fluvastatin The metabolism of Glasdegib can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine The risk or severity of QTc prolongation can be increased when Venlafaxine is combined with Glasdegib.
Lamotrigine Lamotrigine The risk or severity of QTc prolongation can be increased when Lamotrigine is combined with Glasdegib.
Losartan Losartan The risk or severity of QTc prolongation can be increased when Losartan is combined with Glasdegib.
Moexipril Moexipril The risk or severity of QTc prolongation can be increased when Moexipril is combined with Glasdegib.
Lansoprazole Lansoprazole Lansoprazole may decrease the excretion rate of Glasdegib which could result in a higher serum level.
Ifosfamide Injection Ifosfamide Injection The metabolism of Glasdegib can be increased when combined with Ifosfamide.
Nicardipine Nicardipine The risk or severity of QTc prolongation can be increased when Nicardipine is combined with Glasdegib.
Ticlopidine Ticlopidine The metabolism of Glasdegib can be decreased when combined with Ticlopidine.
Saquinavir Saquinavir The risk or severity of QTc prolongation can be increased when Glasdegib is combined with Saquinavir.
Metformin Metformin The excretion of Metformin can be decreased when combined with Glasdegib.
Lamivudine Lamivudine Glasdegib may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Riluzole Riluzole Glasdegib may decrease the excretion rate of Riluzole which could result in a higher serum level.
Anastrozole Anastrozole The metabolism of Glasdegib can be decreased when combined with Anastrozole.
Gemcitabine Injection Gemcitabine Injection The serum concentration of Gemcitabine can be increased when it is combined with Glasdegib.
Ritonavir Ritonavir The serum concentration of Glasdegib can be increased when it is combined with Ritonavir.
Clomipramine Clomipramine The risk or severity of QTc prolongation can be increased when Glasdegib is combined with Clomipramine.
Zafirlukast Zafirlukast The metabolism of Glasdegib can be decreased when combined with Zafirlukast.
Mirtazapine Mirtazapine The risk or severity of QTc prolongation can be increased when Mirtazapine is combined with Glasdegib.
Donepezil Donepezil Glasdegib may decrease the excretion rate of Donepezil which could result in a higher serum level.
Nelfinavir Nelfinavir The risk or severity of QTc prolongation can be increased when Nelfinavir is combined with Glasdegib.
Fexofenadine Fexofenadine The serum concentration of Glasdegib can be increased when it is combined with Fexofenadine.
Azithromycin Azithromycin The risk or severity of QTc prolongation can be increased when Azithromycin is combined with Glasdegib.
Loratadine Loratadine The metabolism of Glasdegib can be decreased when combined with Loratadine.
Carvedilol Carvedilol The serum concentration of Glasdegib can be increased when it is combined with Carvedilol.
Nilutamide Nilutamide The metabolism of Glasdegib can be decreased when combined with Nilutamide.
Selegiline Selegiline The metabolism of Glasdegib can be decreased when combined with Selegiline.
Propafenone Propafenone The risk or severity of QTc prolongation can be increased when Propafenone is combined with Glasdegib.
Raloxifene Raloxifene Glasdegib may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Irbesartan Irbesartan The metabolism of Glasdegib can be decreased when combined with Irbesartan.
Quetiapine Quetiapine The risk or severity of QTc prolongation can be increased when Glasdegib is combined with Quetiapine.
Cetirizine Cetirizine The risk or severity of QTc prolongation can be increased when Cetirizine is combined with Glasdegib.
Citalopram Citalopram The risk or severity of QTc prolongation can be increased when Citalopram is combined with Glasdegib.
Efavirenz Efavirenz The risk or severity of QTc prolongation can be increased when Efavirenz is combined with Glasdegib.
Sildenafil Sildenafil The serum concentration of Sildenafil can be increased when it is combined with Glasdegib.
Pioglitazone Pioglitazone The metabolism of Glasdegib can be decreased when combined with Pioglitazone.
Celecoxib Celecoxib Glasdegib may decrease the excretion rate of Celecoxib which could result in a higher serum level.
Rosiglitazone Rosiglitazone The metabolism of Glasdegib can be decreased when combined with Rosiglitazone.
Tolterodine Tolterodine The risk or severity of QTc prolongation can be increased when Tolterodine is combined with Glasdegib.
Galantamine Galantamine The risk or severity of QTc prolongation can be increased when Galantamine is combined with Glasdegib.
Rabeprazole Rabeprazole The metabolism of Glasdegib can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Glasdegib can be decreased when combined with Terbinafine.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists

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