Fostamatinib

Generic name: Pronounced as (fos" ta ma' ti nib)
Brand names
  • Tavalisse®
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Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 05/15/2018

Fostamatinib is used to treat thrombocytopenia (less than normal number of platelets) in adults with chronic immune thrombocytopenia (ITP; an ongoing condition that may cause unusual bruising or bleeding due to an abnormally low number of platelets in the blood) who were not helped with another treatment. Fostamatinib is in a class of medications called kinase inhibitors. It works by reducing platelet destruction.

Fostamatinib comes as a tablet to take by mouth. It is usually taken with or without food twice daily. Take fostamatinib at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take fostamatinib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor may need to reduce, interrupt, or discontinue your treatment if you experience certain side effects or depending on your treatment response. If your number of platelets (platelet count) does not increase to a certain level after 12 weeks of treatment, your doctor may have to discontinue your treatment. Talk to your doctor about how you are feeling during your treatment.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking fostamatinib,

  • tell your doctor and pharmacist if you are allergic to fostamatinib, any other medications, or any of the ingredients in fostamatinib tablets. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: clarithromycin (Biaxin, in Prevpac), digoxin (Lanoxin), itraconazole (Onmel, Sporanox), ketoconazole, rifampin (Rifadin, Rimactane, in Rifamate, in Rifater), and rosuvastatin (Crestor). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with fostamatinib, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

  • tell your doctor if you have or have ever had high blood pressure or liver disease.

  • tell your doctor if you are pregnant or plan to become pregnant. You will need to have a pregnancy test before you start treatment, and you should use birth control to prevent pregnancy during your fostamatinib treatment and for at least 1 month after your final dose. Talk to your doctor about birth control methods that you can use. If you become pregnant, call your doctor immediately. Fostamatinib may harm the fetus.

  • tell your doctor if you are breastfeeding. You should not breastfeed during your treatment with fostamatinib and for at least 1 month after your final dose.

Unless your doctor tells you otherwise, continue your normal diet.

Skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Fostamatinib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • diarrhea

    • nausea

    • dizziness

    • rash

    • abdominal pain

    • fatigue

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

    • severe diarrhea

    • headache, confusion, dizziness, chest pain, or shortness of breath

    • pain in the upper right part of the stomach

    • yellowing of the skin or eyes

    • dark colored urine

    • nausea

    • vomiting

  • Fostamatinib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Do not remove the desiccant canisters (a small canister that contains a substance that absorbs moisture to keep the medication dry).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to fostamatinib. Your doctor will also check your blood pressure regularly during your treatment with fostamatinib.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Leflunomide Leflunomide Fostamatinib may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Atorvastatin Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Fostamatinib.
Aminophylline Aminophylline The metabolism of Aminophylline can be decreased when combined with Fostamatinib.
Candesartan Candesartan Fostamatinib may increase the antihypertensive activities of Candesartan.
Cilostazol Cilostazol The metabolism of Cilostazol can be decreased when combined with Fostamatinib.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Fostamatinib may decrease the excretion rate of Conjugated estrogens which could result in a higher serum level.
Fenofibrate Fenofibrate The metabolism of Fenofibrate can be decreased when combined with Fostamatinib.
Guanfacine Guanfacine Fostamatinib may increase the antihypertensive activities of Guanfacine.
Mycophenolate Mycophenolate The metabolism of Mycophenolic acid can be decreased when combined with Fostamatinib.
Paregoric Paregoric The metabolism of Morphine can be decreased when combined with Fostamatinib.
Penbutolol Penbutolol Fostamatinib may increase the antihypertensive activities of Acebutolol.
Reserpine Reserpine Fostamatinib may increase the antihypertensive activities of Reserpine.
Sumatriptan Sumatriptan Fostamatinib may decrease the excretion rate of Sumatriptan which could result in a higher serum level.
Tacrolimus Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Fostamatinib.
Tizanidine Tizanidine The risk or severity of hypotension can be increased when Fostamatinib is combined with Tizanidine.
Meperidine Injection Meperidine Injection The metabolism of Meperidine can be decreased when combined with Fostamatinib.
Metronidazole Injection Metronidazole Injection The metabolism of Metronidazole can be decreased when combined with Fostamatinib.
Morphine Injection Morphine Injection The metabolism of Morphine can be decreased when combined with Fostamatinib.
Zidovudine Injection Zidovudine Injection The metabolism of Zidovudine can be decreased when combined with Fostamatinib.
Cyclosporine Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Fostamatinib.
Torsemide Torsemide Fostamatinib may increase the antihypertensive activities of Torasemide.
Olanzapine Olanzapine The risk or severity of hypotension, dyspepsia, and headache can be increased when Fostamatinib is combined with Olanzapine.
Dofetilide Dofetilide The metabolism of Dofetilide can be decreased when combined with Fostamatinib.
Eprosartan Eprosartan Fostamatinib may increase the antihypertensive activities of Eprosartan.
Telmisartan Telmisartan Fostamatinib may increase the antihypertensive activities of Telmisartan.
Trimipramine Trimipramine The risk or severity of hypotension, dyspepsia, and headache can be increased when Fostamatinib is combined with Trimipramine.
Perindopril Perindopril Fostamatinib may increase the antihypertensive activities of Perindopril.
Tenofovir Tenofovir The metabolism of Tenofovir can be decreased when combined with Fostamatinib.
Sirolimus Sirolimus The metabolism of Sirolimus can be decreased when combined with Fostamatinib.
Eplerenone Eplerenone Fostamatinib may increase the antihypertensive activities of Eplerenone.
Olmesartan Olmesartan Fostamatinib may increase the antihypertensive activities of Olmesartan.
Zonisamide Zonisamide The metabolism of Zonisamide can be decreased when combined with Fostamatinib.
Aripiprazole Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Fostamatinib.
Ezetimibe Ezetimibe The metabolism of Ezetimibe can be decreased when combined with Fostamatinib.
Teriparatide Injection Teriparatide Injection The therapeutic efficacy of Teriparatide can be decreased when used in combination with Fostamatinib.
Atazanavir Atazanavir The metabolism of Atazanavir can be decreased when combined with Fostamatinib.
Rosuvastatin Rosuvastatin Fostamatinib may decrease the excretion rate of Rosuvastatin which could result in a higher serum level.
Vardenafil Vardenafil The metabolism of Vardenafil can be decreased when combined with Fostamatinib.
Alfuzosin Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Fostamatinib.
Tegaserod Tegaserod Fostamatinib may decrease the excretion rate of Tegaserod which could result in a higher serum level.
Tadalafil Tadalafil The risk or severity of adverse effects can be increased when Fostamatinib is combined with Tadalafil.
Apomorphine Injection Apomorphine Injection The risk or severity of hypotension can be increased when Fostamatinib is combined with Apomorphine.
Duloxetine Duloxetine The metabolism of Duloxetine can be decreased when combined with Fostamatinib.
Norethindrone Norethindrone The metabolism of Norethisterone can be decreased when combined with Fostamatinib.
Bosentan Bosentan Fostamatinib may increase the antihypertensive activities of Bosentan.
Erlotinib Erlotinib The metabolism of Erlotinib can be decreased when combined with Fostamatinib.
Eszopiclone Eszopiclone The metabolism of Eszopiclone can be decreased when combined with Fostamatinib.
Isocarboxazid Isocarboxazid The risk or severity of hypotension can be increased when Fostamatinib is combined with Isocarboxazid.
Fentanyl Fentanyl The metabolism of Fentanyl can be decreased when combined with Fostamatinib.
Deferasirox Deferasirox The metabolism of Fostamatinib can be decreased when combined with Deferasirox.
Phenylephrine Phenylephrine The risk or severity of hypertension can be decreased when Fostamatinib is combined with Phenylephrine.
Rasagiline Rasagiline The risk or severity of hypotension can be increased when Fostamatinib is combined with Rasagiline.
Imatinib Imatinib Fostamatinib may decrease the excretion rate of Imatinib which could result in a higher serum level.
Gefitinib Gefitinib Fostamatinib may decrease the excretion rate of Gefitinib which could result in a higher serum level.
Paliperidone Paliperidone The risk or severity of hypotension, dyspepsia, and headache can be increased when Fostamatinib is combined with Paliperidone.
Bortezomib Bortezomib The metabolism of Bortezomib can be decreased when combined with Fostamatinib.
Clofarabine Injection Clofarabine Injection Fostamatinib may decrease the excretion rate of Clofarabine which could result in a higher serum level.
Fulvestrant Injection Fulvestrant Injection The metabolism of Fulvestrant can be decreased when combined with Fostamatinib.
Oxaliplatin Injection Oxaliplatin Injection Fostamatinib may decrease the excretion rate of Oxaliplatin which could result in a higher serum level.
Aliskiren Aliskiren Fostamatinib may increase the antihypertensive activities of Aliskiren.
Nabilone Nabilone The risk or severity of hypotension can be increased when Fostamatinib is combined with Nabilone.
Retapamulin Retapamulin The metabolism of Retapamulin can be decreased when combined with Fostamatinib.
Sorafenib Sorafenib The metabolism of Fostamatinib can be decreased when combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Sunitinib can be decreased when combined with Fostamatinib.
Dasatinib Dasatinib The metabolism of Dasatinib can be decreased when combined with Fostamatinib.
Ivermectin Ivermectin Fostamatinib may decrease the excretion rate of Ivermectin which could result in a higher serum level.
Temsirolimus Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Fostamatinib.
Nilotinib Nilotinib The metabolism of Nilotinib can be decreased when combined with Fostamatinib.
Raltegravir Raltegravir The metabolism of Raltegravir can be decreased when combined with Fostamatinib.
Arsenic Trioxide Injection Arsenic Trioxide Injection The risk or severity of hypotension can be increased when Fostamatinib is combined with Arsenic trioxide.
Mitoxantrone Injection Mitoxantrone Injection Fostamatinib may decrease the excretion rate of Mitoxantrone which could result in a higher serum level.
Sapropterin Sapropterin Sapropterin may increase the hypotensive activities of Fostamatinib.
Nebivolol Nebivolol Fostamatinib may increase the antihypertensive activities of Nebivolol.
Tretinoin Tretinoin The risk or severity of hypotension can be increased when Fostamatinib is combined with Tretinoin.
Ixabepilone Injection Ixabepilone Injection The metabolism of Ixabepilone can be decreased when combined with Fostamatinib.
Irinotecan Injection Irinotecan Injection The risk or severity of neutropenia can be increased when Fostamatinib is combined with Irinotecan.
Rufinamide Rufinamide The metabolism of Rufinamide can be decreased when combined with Fostamatinib.
Silodosin Silodosin The risk or severity of hypotension, dyspepsia, and headache can be increased when Fostamatinib is combined with Silodosin.
Midazolam Midazolam The serum concentration of Midazolam can be increased when it is combined with Fostamatinib.
Naltrexone Injection Naltrexone Injection The metabolism of Naltrexone can be decreased when combined with Fostamatinib.
Eltrombopag Eltrombopag The metabolism of Eltrombopag can be decreased when combined with Fostamatinib.
Betaxolol Betaxolol Fostamatinib may increase the antihypertensive activities of Betaxolol.
Iloperidone Iloperidone The metabolism of Iloperidone can be decreased when combined with Fostamatinib.
Lacosamide Lacosamide The metabolism of Lacosamide can be decreased when combined with Fostamatinib.
Everolimus Everolimus The metabolism of Everolimus can be decreased when combined with Fostamatinib.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The metabolism of Tolvaptan can be decreased when combined with Fostamatinib.
Dronedarone Dronedarone The metabolism of Dronedarone can be decreased when combined with Fostamatinib.
Pralatrexate Injection Pralatrexate Injection Fostamatinib may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Romidepsin Injection Romidepsin Injection The metabolism of Romidepsin can be decreased when combined with Fostamatinib.
Topotecan Topotecan Fostamatinib may decrease the excretion rate of Topotecan which could result in a higher serum level.
Pazopanib Pazopanib The metabolism of Pazopanib can be decreased when combined with Fostamatinib.
Asenapine Asenapine The risk or severity of hypotension, dyspepsia, and headache can be increased when Fostamatinib is combined with Asenapine.
Pitavastatin Pitavastatin Fostamatinib may decrease the excretion rate of Pitavastatin which could result in a higher serum level.
Albendazole Albendazole The metabolism of Albendazole can be decreased when combined with Fostamatinib.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Cabazitaxel can be decreased when combined with Fostamatinib.
Acetaminophen Injection Acetaminophen Injection The metabolism of Acetaminophen can be decreased when combined with Fostamatinib.
Denileukin Diftitox Injection Denileukin Diftitox Injection The risk or severity of hypotension can be increased when Fostamatinib is combined with Aldesleukin.
Azilsartan Azilsartan The risk or severity of hypotension can be increased when Fostamatinib is combined with Azilsartan medoxomil.
Busulfan Injection Busulfan Injection The metabolism of Busulfan can be decreased when combined with Fostamatinib.
Roflumilast Roflumilast The metabolism of Roflumilast can be decreased when combined with Fostamatinib.
Linagliptin Linagliptin The metabolism of Linagliptin can be decreased when combined with Fostamatinib.
Telaprevir Telaprevir Fostamatinib may decrease the excretion rate of Glecaprevir which could result in a higher serum level.
Potassium Iodide Potassium Iodide The therapeutic efficacy of Potassium Iodide can be decreased when used in combination with Fostamatinib.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Cyclophosphamide can be decreased when combined with Fostamatinib.
Rivaroxaban Rivaroxaban Fostamatinib may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Brentuximab vedotin can be decreased when combined with Fostamatinib.
Ruxolitinib Ruxolitinib The metabolism of Ruxolitinib can be decreased when combined with Fostamatinib.
Vandetanib Vandetanib The metabolism of Vandetanib can be decreased when combined with Fostamatinib.
Vemurafenib Vemurafenib The metabolism of Vemurafenib can be decreased when combined with Fostamatinib.
Axitinib Axitinib The metabolism of Axitinib can be decreased when combined with Fostamatinib.
Crizotinib Crizotinib The metabolism of Crizotinib can be decreased when combined with Fostamatinib.
Cabergoline Cabergoline The metabolism of Cabergoline can be decreased when combined with Fostamatinib.
Naloxone Injection Naloxone Injection The metabolism of Naloxone can be decreased when combined with Fostamatinib.
Ambrisentan Ambrisentan Fostamatinib may increase the antihypertensive activities of Ambrisentan.
Ezogabine Ezogabine The metabolism of Tiagabine can be decreased when combined with Fostamatinib.
Iloprost Iloprost The risk or severity of hypotension can be increased when Fostamatinib is combined with Iloprost.
Regorafenib Regorafenib The metabolism of Fostamatinib can be decreased when combined with Regorafenib.
Bosutinib Bosutinib The metabolism of Bosutinib can be decreased when combined with Fostamatinib.
Teriflunomide Teriflunomide Fostamatinib may decrease the excretion rate of Teriflunomide which could result in a higher serum level.
Tofacitinib Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Fostamatinib.
Ponatinib Ponatinib The metabolism of Ponatinib can be decreased when combined with Fostamatinib.
Pomalidomide Pomalidomide The metabolism of Pomalidomide can be decreased when combined with Fostamatinib.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be decreased when combined with Fostamatinib.
Apixaban Apixaban Fostamatinib may decrease the excretion rate of Apixaban which could result in a higher serum level.
Canagliflozin Canagliflozin The risk or severity of hypotension can be increased when Fostamatinib is combined with Canagliflozin.
Methazolamide Methazolamide The risk or severity of hypotension can be increased when Fostamatinib is combined with Methazolamide.
Dabrafenib Dabrafenib The metabolism of Dabrafenib can be decreased when combined with Fostamatinib.
Dolutegravir Dolutegravir The metabolism of Dolutegravir can be decreased when combined with Fostamatinib.
Afatinib Afatinib Fostamatinib may decrease the excretion rate of Afatinib which could result in a higher serum level.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Fostamatinib.
Lomitapide Lomitapide The metabolism of Lomitapide can be decreased when combined with Fostamatinib.
Avanafil Avanafil The risk or severity of adverse effects can be increased when Avanafil is combined with Fostamatinib.
Obinutuzumab Injection Obinutuzumab Injection The risk or severity of hypotension can be increased when Fostamatinib is combined with Obinutuzumab.
Simeprevir Simeprevir Fostamatinib may decrease the excretion rate of Simeprevir which could result in a higher serum level.
Sofosbuvir Sofosbuvir Fostamatinib may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin Dapagliflozin The risk or severity of hypotension can be increased when Fostamatinib is combined with Dapagliflozin.
Ceritinib Ceritinib The metabolism of Ceritinib can be decreased when combined with Fostamatinib.
Eslicarbazepine Eslicarbazepine The metabolism of Eslicarbazepine can be decreased when combined with Fostamatinib.
Belinostat Injection Belinostat Injection The metabolism of Belinostat can be decreased when combined with Fostamatinib.
Idelalisib Idelalisib The metabolism of Idelalisib can be decreased when combined with Fostamatinib.
Testosterone Injection Testosterone Injection Fostamatinib may decrease the excretion rate of Testosterone which could result in a higher serum level.
Empagliflozin Empagliflozin The risk or severity of hypotension can be increased when Fostamatinib is combined with Empagliflozin.
Vorapaxar Vorapaxar The metabolism of Vorapaxar can be decreased when combined with Fostamatinib.
Suvorexant Suvorexant The metabolism of Suvorexant can be decreased when combined with Fostamatinib.
Olaparib Olaparib The metabolism of Olaparib can be decreased when combined with Fostamatinib.
Tasimelteon Tasimelteon The metabolism of Tasimelteon can be decreased when combined with Fostamatinib.
Riociguat Riociguat Fostamatinib may increase the hypotensive activities of Riociguat.
Nintedanib Nintedanib The metabolism of Nintedanib can be decreased when combined with Fostamatinib.
Risperidone Injection Risperidone Injection The risk or severity of hypotension, dyspepsia, and headache can be increased when Fostamatinib is combined with Risperidone.
Palbociclib Palbociclib The metabolism of Palbociclib can be decreased when combined with Fostamatinib.
Lenvatinib Lenvatinib Fostamatinib may decrease the excretion rate of Lenvatinib which could result in a higher serum level.
Panobinostat Panobinostat The metabolism of Panobinostat can be decreased when combined with Fostamatinib.
Dinutuximab Injection Dinutuximab Injection The risk or severity of hypotension can be increased when Fostamatinib is combined with Dinutuximab.
Haloperidol Injection Haloperidol Injection The serum concentration of Haloperidol can be increased when it is combined with Fostamatinib.
Amiloride Amiloride The risk or severity of hypotension can be increased when Fostamatinib is combined with Amiloride.
Macitentan Macitentan Fostamatinib may increase the antihypertensive activities of Macitentan.
Sonidegib Sonidegib The metabolism of Sonidegib can be decreased when combined with Fostamatinib.
Brexpiprazole Brexpiprazole The risk or severity of hypotension, dyspepsia, and headache can be increased when Fostamatinib is combined with Brexpiprazole.
Ziprasidone Injection Ziprasidone Injection The risk or severity of hypotension, dyspepsia, and headache can be increased when Fostamatinib is combined with Ziprasidone.
Cobimetinib Cobimetinib The metabolism of Cobimetinib can be decreased when combined with Fostamatinib.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Fostamatinib.
Osimertinib Osimertinib The metabolism of Osimertinib can be decreased when combined with Fostamatinib.
Alectinib Alectinib The metabolism of Alectinib can be decreased when combined with Fostamatinib.
Ixazomib Ixazomib The metabolism of Ixazomib can be decreased when combined with Fostamatinib.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The risk or severity of hypotension can be increased when Fostamatinib is combined with Amphotericin B.
Venetoclax Venetoclax The metabolism of Venetoclax can be decreased when combined with Fostamatinib.
Selexipag Selexipag Fostamatinib may increase the antihypertensive activities of Selexipag.
Furosemide Injection Furosemide Injection The metabolism of Furosemide can be decreased when combined with Fostamatinib.
Rucaparib Rucaparib Fostamatinib may decrease the excretion rate of Rucaparib which could result in a higher serum level.
Ribociclib Ribociclib The metabolism of Ribociclib can be decreased when combined with Fostamatinib.
Parathyroid Hormone Injection Parathyroid Hormone Injection The therapeutic efficacy of Parathyroid hormone can be decreased when used in combination with Fostamatinib.
Brigatinib Brigatinib The metabolism of Brigatinib can be decreased when combined with Fostamatinib.
Doxepin (Insomnia) Doxepin (Insomnia) The risk or severity of hypotension, dyspepsia, and headache can be increased when Fostamatinib is combined with Doxepin.
Midostaurin Midostaurin The metabolism of Midostaurin can be decreased when combined with Fostamatinib.
Neratinib Neratinib The metabolism of Neratinib can be decreased when combined with Fostamatinib.
Abaloparatide Injection Abaloparatide Injection The therapeutic efficacy of Abaloparatide can be decreased when used in combination with Fostamatinib.
Enasidenib Enasidenib The metabolism of Enasidenib can be decreased when combined with Fostamatinib.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Fosaprepitant can be decreased when combined with Fostamatinib.
Copanlisib Injection Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Fostamatinib.
Delafloxacin Delafloxacin The metabolism of Delafloxacin can be decreased when combined with Fostamatinib.
Abemaciclib Abemaciclib The metabolism of Abemaciclib can be decreased when combined with Fostamatinib.
Acalabrutinib Acalabrutinib The metabolism of Acalabrutinib can be decreased when combined with Fostamatinib.
Letermovir Letermovir The metabolism of Letermovir can be decreased when combined with Fostamatinib.
Ertugliflozin Ertugliflozin Fostamatinib may decrease the excretion rate of Ertugliflozin which could result in a higher serum level.
Buprenorphine Injection Buprenorphine Injection The metabolism of Buprenorphine can be decreased when combined with Fostamatinib.
Baricitinib Baricitinib The metabolism of Baricitinib can be decreased when combined with Fostamatinib.
Lofexidine Lofexidine Fostamatinib may increase the antihypertensive activities of Lofexidine.
Eliglustat Eliglustat The metabolism of Eliglustat can be decreased when combined with Fostamatinib.
Binimetinib Binimetinib The metabolism of Binimetinib can be decreased when combined with Fostamatinib.
Ivosidenib Ivosidenib The metabolism of Ivosidenib can be decreased when combined with Fostamatinib.
Lusutrombopag Lusutrombopag Fostamatinib may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Elagolix Elagolix The metabolism of Elagolix can be decreased when combined with Fostamatinib.
Dacomitinib Dacomitinib The metabolism of Dacomitinib can be decreased when combined with Fostamatinib.
Duvelisib Duvelisib Fostamatinib may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Talazoparib Talazoparib Fostamatinib may decrease the excretion rate of Talazoparib which could result in a higher serum level.
Gilteritinib Gilteritinib The metabolism of Gilteritinib can be decreased when combined with Fostamatinib.
Glasdegib Glasdegib Fostamatinib may decrease the excretion rate of Glasdegib which could result in a higher serum level.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Fostamatinib.
Prucalopride Prucalopride The metabolism of Prucalopride can be decreased when combined with Fostamatinib.
Siponimod Siponimod The metabolism of Siponimod can be decreased when combined with Fostamatinib.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Fostamatinib.
Alpelisib Alpelisib The serum concentration of Alpelisib can be increased when it is combined with Fostamatinib.
Cladribine Cladribine Fostamatinib may decrease the excretion rate of Cladribine which could result in a higher serum level.
Darolutamide Darolutamide Fostamatinib may decrease the excretion rate of Darolutamide which could result in a higher serum level.
Entrectinib Entrectinib The metabolism of Entrectinib can be decreased when combined with Fostamatinib.
Pexidartinib Pexidartinib The metabolism of Pexidartinib can be decreased when combined with Fostamatinib.
Pitolisant Pitolisant The serum concentration of Fostamatinib can be decreased when it is combined with Pitolisant.
Lefamulin Lefamulin The metabolism of Lefamulin can be decreased when combined with Fostamatinib.
Phenytoin Injection Phenytoin Injection The metabolism of Fostamatinib can be decreased when combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Fosphenytoin can be decreased when combined with Fostamatinib.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Fostamatinib.
Voxelotor Voxelotor The serum concentration of Voxelotor can be increased when it is combined with Fostamatinib.
Lumateperone Lumateperone The serum concentration of Lumateperone can be increased when it is combined with Fostamatinib.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Fostamatinib.
Tazemetostat Tazemetostat Fostamatinib may decrease the excretion rate of Tazemetostat which could result in a higher serum level.
Cenobamate Cenobamate The serum concentration of Fostamatinib can be decreased when it is combined with Cenobamate.
Ozanimod Ozanimod Fostamatinib may decrease the excretion rate of Ozanimod which could result in a higher serum level.
Selumetinib Selumetinib Fostamatinib may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Rimegepant Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Fostamatinib.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Fostamatinib.
Sacituzumab govitecan-hziy Injection Sacituzumab govitecan-hziy Injection The serum concentration of Sacituzumab govitecan can be increased when it is combined with Fostamatinib.
Ripretinib Ripretinib Fostamatinib may decrease the excretion rate of Ripretinib which could result in a higher serum level.
Fostemsavir Fostemsavir Fostamatinib may decrease the excretion rate of Fostemsavir which could result in a higher serum level.
Pralsetinib Pralsetinib Fostamatinib may decrease the excretion rate of Pralsetinib which could result in a higher serum level.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Fostamatinib can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Drospirenone can be decreased when combined with Fostamatinib.
Theophylline Theophylline The metabolism of Theophylline can be decreased when combined with Fostamatinib.
Indomethacin Indomethacin The metabolism of Indomethacin can be decreased when combined with Fostamatinib.
Mefenamic Acid Mefenamic Acid The metabolism of Fostamatinib can be decreased when combined with Mefenamic acid.
Naproxen Naproxen The metabolism of Naproxen can be decreased when combined with Fostamatinib.
Trazodone Trazodone The risk or severity of hypotension, dyspepsia, and headache can be increased when Fostamatinib is combined with Trazodone.
Methotrexate Injection Methotrexate Injection The metabolism of Methotrexate can be decreased when combined with Fostamatinib.
Chlorpromazine Chlorpromazine The risk or severity of hypotension, dyspepsia, and headache can be increased when Fostamatinib is combined with Chlorpromazine.
Lorazepam Lorazepam The metabolism of Lorazepam can be decreased when combined with Fostamatinib.
Phenoxybenzamine Phenoxybenzamine The risk or severity of hypotension, dyspepsia, and headache can be increased when Fostamatinib is combined with Phenoxybenzamine.
Bromocriptine Bromocriptine The risk or severity of hypotension, dyspepsia, and headache can be increased when Fostamatinib is combined with Bromocriptine.
Tranylcypromine Tranylcypromine The risk or severity of hypotension can be increased when Fostamatinib is combined with Tranylcypromine.
Phenelzine Phenelzine The risk or severity of hypotension can be increased when Fostamatinib is combined with Phenelzine.
Prochlorperazine Prochlorperazine The metabolism of Prochlorperazine can be decreased when combined with Fostamatinib.
Thioridazine Thioridazine The risk or severity of hypotension, dyspepsia, and headache can be increased when Fostamatinib is combined with Thioridazine.
Trifluoperazine Trifluoperazine The risk or severity of hypotension, dyspepsia, and headache can be increased when Fostamatinib is combined with Trifluoperazine.
Ibuprofen Ibuprofen The metabolism of Ibuprofen can be decreased when combined with Fostamatinib.
Phentermine Phentermine The metabolism of Phentermine can be decreased when combined with Fostamatinib.
Amoxapine Amoxapine The risk or severity of hypotension, dyspepsia, and headache can be increased when Fostamatinib is combined with Amoxapine.
Sulfasalazine Sulfasalazine Fostamatinib may decrease the excretion rate of Sulfasalazine which could result in a higher serum level.
Doxorubicin Doxorubicin The metabolism of Doxorubicin can be decreased when combined with Fostamatinib.
Dactinomycin Dactinomycin Fostamatinib may decrease the excretion rate of Dactinomycin which could result in a higher serum level.
Carbamazepine Carbamazepine The metabolism of Carbamazepine can be decreased when combined with Fostamatinib.
Methyldopa Methyldopa Fostamatinib may increase the antihypertensive activities of Methyldopa.
Clonidine Clonidine The metabolism of Clonidine can be decreased when combined with Fostamatinib.
Prazosin Prazosin Fostamatinib may decrease the excretion rate of Prazosin which could result in a higher serum level.
Hydralazine Hydralazine Fostamatinib may increase the antihypertensive activities of Hydralazine.
Warfarin Warfarin The serum concentration of Warfarin can be increased when it is combined with Fostamatinib.
Daunorubicin Daunorubicin Fostamatinib may decrease the excretion rate of Daunorubicin which could result in a higher serum level.
Nitrofurantoin Nitrofurantoin Fostamatinib may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Triamterene Triamterene The risk or severity of hypotension can be increased when Fostamatinib is combined with Triamterene.
Chlorothiazide Chlorothiazide Fostamatinib may increase the antihypertensive activities of Chlorothiazide.
Chlorthalidone Chlorthalidone Fostamatinib may increase the antihypertensive activities of Chlorthalidone.
Metolazone Metolazone Fostamatinib may increase the antihypertensive activities of Metolazone.
Isosorbide Isosorbide The risk or severity of hypotension can be increased when Fostamatinib is combined with Isosorbide.
Amitriptyline Amitriptyline The risk or severity of hypotension, dyspepsia, and headache can be increased when Fostamatinib is combined with Amitriptyline.
Imipramine Imipramine The risk or severity of hypotension, dyspepsia, and headache can be increased when Fostamatinib is combined with Imipramine.
Quinidine Quinidine The metabolism of Quinidine can be decreased when combined with Fostamatinib.
Rifampin Rifampin The metabolism of Fostamatinib can be decreased when combined with Rifampicin.
Valproic Acid Valproic Acid The metabolism of Valproic acid can be decreased when combined with Fostamatinib.
Tamoxifen Tamoxifen The metabolism of Tamoxifen can be decreased when combined with Fostamatinib.
Levothyroxine Levothyroxine The therapeutic efficacy of Levothyroxine can be decreased when used in combination with Fostamatinib.
Liothyronine Liothyronine The therapeutic efficacy of Liothyronine can be decreased when used in combination with Fostamatinib.
Methimazole Methimazole The therapeutic efficacy of Methimazole can be decreased when used in combination with Fostamatinib.
Propylthiouracil Propylthiouracil The therapeutic efficacy of Propylthiouracil can be decreased when used in combination with Fostamatinib.
Methyclothiazide Methyclothiazide The risk or severity of hypotension can be increased when Fostamatinib is combined with Methyclothiazide.
Hydrochlorothiazide Hydrochlorothiazide Fostamatinib may increase the antihypertensive activities of Hydrochlorothiazide.
Folic Acid Folic Acid Fostamatinib may decrease the excretion rate of Folic acid which could result in a higher serum level.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) Fostamatinib may increase the antihypertensive activities of Propranolol.
Minoxidil Minoxidil The metabolism of Minoxidil can be decreased when combined with Fostamatinib.
Nortriptyline Nortriptyline The metabolism of Nortriptyline can be decreased when combined with Fostamatinib.
Spironolactone Spironolactone The risk or severity of hypotension can be increased when Fostamatinib is combined with Spironolactone.
Amphotericin B Injection Amphotericin B Injection The risk or severity of hypotension can be increased when Fostamatinib is combined with Amphotericin B.
Nadolol Nadolol Fostamatinib may increase the antihypertensive activities of Nadolol.
Allopurinol Allopurinol Fostamatinib may decrease the excretion rate of Allopurinol which could result in a higher serum level.
Papaverine Papaverine The risk or severity of hypotension can be increased when Fostamatinib is combined with Papaverine.
Fluorouracil Injection Fluorouracil Injection Fostamatinib may decrease the excretion rate of Fluorouracil which could result in a higher serum level.
Colchicine Colchicine The metabolism of Colchicine can be decreased when combined with Fostamatinib.
Cephalexin Cephalexin The metabolism of Cephalexin can be decreased when combined with Fostamatinib.
Calcitonin Salmon Injection Calcitonin Salmon Injection The therapeutic efficacy of Salmon calcitonin can be decreased when used in combination with Fostamatinib.
Thiotepa Injection Thiotepa Injection The metabolism of Thiotepa can be decreased when combined with Fostamatinib.
Vincristine Injection Vincristine Injection The metabolism of Vincristine can be decreased when combined with Fostamatinib.
Captopril Captopril Fostamatinib may increase the antihypertensive activities of Captopril.
Dipyridamole Dipyridamole The risk or severity of adverse effects can be increased when Dipyridamole is combined with Fostamatinib.
Isoxsuprine Isoxsuprine The risk or severity of hypotension can be increased when Fostamatinib is combined with Isoxsuprine.
Vinblastine Vinblastine The metabolism of Vinblastine can be decreased when combined with Fostamatinib.
Ethacrynic Acid Ethacrynic Acid The risk or severity of hypotension can be increased when Fostamatinib is combined with Etacrynic acid.
Metoprolol Metoprolol The metabolism of Metoprolol can be decreased when combined with Fostamatinib.
Alprazolam Alprazolam The metabolism of Alprazolam can be decreased when combined with Fostamatinib.
Diltiazem Diltiazem Fostamatinib may increase the antihypertensive activities of Diltiazem.
Nifedipine Nifedipine The risk or severity of hypotension can be increased when Fostamatinib is combined with Nifedipine.
Timolol Timolol Fostamatinib may increase the antihypertensive activities of Timolol.
Verapamil Verapamil The risk or severity of hypotension, dyspepsia, and headache can be increased when Fostamatinib is combined with Verapamil.
Atenolol Atenolol Fostamatinib may increase the antihypertensive activities of Atenolol.
Pindolol Pindolol Fostamatinib may increase the antihypertensive activities of Pindolol.
Diflunisal Diflunisal The metabolism of Fostamatinib can be decreased when combined with Diflunisal.
Bumetanide Bumetanide The risk or severity of hypotension can be increased when Fostamatinib is combined with Bumetanide.
Etoposide Etoposide The metabolism of Etoposide can be decreased when combined with Fostamatinib.
Glyburide Glyburide Fostamatinib may decrease the excretion rate of Glyburide which could result in a higher serum level.
Glipizide Glipizide The metabolism of Glipizide can be decreased when combined with Fostamatinib.
Indapamide Indapamide Fostamatinib may increase the antihypertensive activities of Indapamide.
Pentoxifylline Pentoxifylline The risk or severity of adverse effects can be increased when Pentoxifylline is combined with Fostamatinib.
Labetalol Labetalol The metabolism of Labetalol can be decreased when combined with Fostamatinib.
Gemfibrozil Gemfibrozil The metabolism of Gemfibrozil can be decreased when combined with Fostamatinib.
Guanabenz Guanabenz Fostamatinib may increase the antihypertensive activities of Guanabenz.
Ketoprofen Ketoprofen The metabolism of Ketoprofen can be decreased when combined with Fostamatinib.
Pimozide Pimozide The metabolism of Pimozide can be decreased when combined with Fostamatinib.
Enalapril Enalapril Fostamatinib may increase the antihypertensive activities of Enalapril.
Flurbiprofen Flurbiprofen The metabolism of Flurbiprofen can be decreased when combined with Fostamatinib.
Amiodarone Amiodarone The metabolism of Amiodarone can be decreased when combined with Fostamatinib.
Lovastatin Lovastatin The metabolism of Lovastatin can be decreased when combined with Fostamatinib.
Diclofenac Diclofenac The metabolism of Diclofenac can be decreased when combined with Fostamatinib.
Nimodipine Nimodipine Fostamatinib may increase the antihypertensive activities of Nimodipine.
Clozapine Clozapine The risk or severity of hypotension, dyspepsia, and headache can be increased when Fostamatinib is combined with Clozapine.
Benazepril Benazepril Fostamatinib may increase the antihypertensive activities of Benazepril.
Felodipine Felodipine Fostamatinib may increase the antihypertensive activities of Felodipine.
Fosinopril Fosinopril Fostamatinib may increase the antihypertensive activities of Fosinopril.
Pravastatin Pravastatin Fostamatinib may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Quinapril Quinapril Fostamatinib may increase the antihypertensive activities of Quinapril.
Ramipril Ramipril Fostamatinib may increase the antihypertensive activities of Ramipril.
Simvastatin Simvastatin The metabolism of Simvastatin can be decreased when combined with Fostamatinib.
Amlodipine Amlodipine Fostamatinib may increase the antihypertensive activities of Amlodipine.
Teniposide Injection Teniposide Injection The metabolism of Teniposide can be decreased when combined with Fostamatinib.
Lisinopril Lisinopril Fostamatinib may increase the antihypertensive activities of Lisinopril.
Sotalol Sotalol The risk or severity of hypotension can be increased when Fostamatinib is combined with Sotalol.
Bisoprolol Bisoprolol Fostamatinib may increase the antihypertensive activities of Bisoprolol.
Doxazosin Doxazosin The risk or severity of hypotension can be increased when Fostamatinib is combined with Doxazosin.
Terazosin Terazosin The risk or severity of hypotension, dyspepsia, and headache can be increased when Fostamatinib is combined with Terazosin.
Isradipine Isradipine Fostamatinib may increase the antihypertensive activities of Isradipine.
Cisapride Cisapride The metabolism of Cisapride can be decreased when combined with Fostamatinib.
Fluvastatin Fluvastatin The metabolism of Fluvastatin can be decreased when combined with Fostamatinib.
Famciclovir Famciclovir The metabolism of Famciclovir can be decreased when combined with Fostamatinib.
Nefazodone Nefazodone The risk or severity of hypotension, dyspepsia, and headache can be increased when Fostamatinib is combined with Nefazodone.
Lamotrigine Lamotrigine The metabolism of Lamotrigine can be decreased when combined with Fostamatinib.
Losartan Losartan The metabolism of Losartan can be decreased when combined with Fostamatinib.
Tramadol Tramadol The metabolism of Tramadol can be decreased when combined with Fostamatinib.
Vinorelbine Injection Vinorelbine Injection The metabolism of Vinorelbine can be decreased when combined with Fostamatinib.
Moexipril Moexipril Fostamatinib may increase the antihypertensive activities of Moexipril.
Alprostadil Urogenital Alprostadil Urogenital The risk or severity of hypotension and priapism can be increased when Fostamatinib is combined with Alprostadil.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ifosfamide can be decreased when combined with Fostamatinib.
Nicardipine Nicardipine The risk or severity of hypotension, dyspepsia, and headache can be increased when Fostamatinib is combined with Nicardipine.
Ticlopidine Ticlopidine The metabolism of Ticlopidine can be decreased when combined with Fostamatinib.
Nisoldipine Nisoldipine Fostamatinib may increase the antihypertensive activities of Nisoldipine.
Lamivudine Lamivudine Fostamatinib may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Riluzole Riluzole Fostamatinib may decrease the excretion rate of Riluzole which could result in a higher serum level.
Amifostine Injection Amifostine Injection The risk or severity of hypotension can be increased when Fostamatinib is combined with Amifostine.
Ritonavir Ritonavir The serum concentration of R406, an active metabolite of Ritonavir, can be increased when used in combination with Fostamatinib.
Docetaxel Injection Docetaxel Injection The metabolism of Docetaxel can be decreased when combined with Fostamatinib.
Clomipramine Clomipramine The metabolism of Clomipramine can be decreased when combined with Fostamatinib.
Zafirlukast Zafirlukast The metabolism of Fostamatinib can be decreased when combined with Zafirlukast.
Trandolapril Trandolapril Fostamatinib may increase the antihypertensive activities of Trandolapril.
Valsartan Valsartan Fostamatinib may increase the antihypertensive activities of Valsartan.
Pramipexole Pramipexole The risk or severity of hypotension can be increased when Fostamatinib is combined with Pramipexole.
Donepezil Donepezil Fostamatinib may decrease the excretion rate of Donepezil which could result in a higher serum level.
Azithromycin Azithromycin The metabolism of Azithromycin can be decreased when combined with Fostamatinib.
Carvedilol Carvedilol The metabolism of Carvedilol can be decreased when combined with Fostamatinib.
Selegiline Selegiline The risk or severity of hypotension can be increased when Fostamatinib is combined with Selegiline.
Bicalutamide Bicalutamide The metabolism of Bicalutamide can be decreased when combined with Fostamatinib.
Raloxifene Raloxifene The metabolism of Raloxifene can be decreased when combined with Fostamatinib.
Irbesartan Irbesartan Fostamatinib may increase the antihypertensive activities of Irbesartan.
Tamsulosin Tamsulosin The risk or severity of hypotension, dyspepsia, and headache can be increased when Fostamatinib is combined with Tamsulosin.
Ropinirole Ropinirole The risk or severity of hypotension can be increased when Fostamatinib is combined with Ropinirole.
Quetiapine Quetiapine The risk or severity of hypotension, dyspepsia, and headache can be increased when Fostamatinib is combined with Quetiapine.
Tolcapone Tolcapone The risk or severity of hypotension can be increased when Fostamatinib is combined with Tolcapone.
Abacavir Abacavir The metabolism of Abacavir can be decreased when combined with Fostamatinib.
Sildenafil Sildenafil The risk or severity of adverse effects can be increased when Sildenafil is combined with Fostamatinib.
Celecoxib Celecoxib Fostamatinib may decrease the excretion rate of Celecoxib which could result in a higher serum level.
Thalidomide Thalidomide The risk or severity of hypotension can be increased when Fostamatinib is combined with Thalidomide.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists

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