Drug & supplement interaction

Humann Superbeets Heart Chews + Benzhydrocodone, Acetaminophen

Benzhydrocodone, Acetaminophen brand name: Apadaz.

Minor Interaction
Medically reviewed by · Updated November 2023
The bottom line Minor

Benzhydrocodone, Acetaminophen falls into 4 drug categories that Humann Superbeets Heart Chews can interact with; the most serious is rated minor. Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Read the full interaction report
SeverityMinor
LikelihoodUnlikely
Interactions4
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Humann Superbeets Heart Chews and Benzhydrocodone, Acetaminophen

These two interact in 4 distinct ways. Each one is explained separately below.

Why Are There 4 Interactions?

Humann Superbeets Heart Chews interacts with whole categories of medication. Benzhydrocodone, Acetaminophen falls into 4 of those categories, so it can interact with Humann Superbeets Heart Chews in 4 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Minor).

Minor

Cytochrome P450 2D6 (Cyp2D6) Substrates

1 of 4

Why this applies to Benzhydrocodone, Acetaminophen

Benzhydrocodone, Acetaminophen falls under Cytochrome P450 2D6 (Cyp2D6) Substrates — the group Humann Superbeets Heart Chews interacts with.

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews). Laboratory studies suggest that grape seed extract might have inhibitory effects on the CYP2D6 metabolizing enzyme. If this enzyme is inhibited, drugs metabolized by it may undergo slower metabolism, potentially leading to (in many cases) higher-than-normal drug levels. Elevated drug levels can increase the risk of experiencing side effects. However, it's crucial to highlight that, as of now, there is no documented or reported instance of this specific interaction occurring in human studies.
Severity Minor Likelihood Unlikely Evidence D

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's something interesting about Apadaz: the benzhydrocodone part is actually a prodrug. Your body has to convert it into hydrocodone, and the CYP2D6 enzyme then turns hydrocodone into its more active pain-relieving form. The grape seed extract in SuperBeets Heart Chews may gently slow CYP2D6, at least in lab studies. So in theory, you might get a little less pain relief from this medicine, rather than too much.

That said, this is very weak, theory-only evidence, and there are no real human reports of it happening. I wouldn't lose sleep over it. If you ever feel your pain isn't being controlled the way it should be, mention these chews to your pharmacist or doctor so they can take a look.

Contact Dr. Brian directly if you have additional questions on this interaction
Minor

Cytochrome P450 3A4 (Cyp3A4) Substrates

2 of 4

Benzhydrocodone, Acetaminophen also falls under Cytochrome P450 3A4 (Cyp3A4) Substrates.

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews). Laboratory studies suggest that grape seed extract might have inhibitory effects on the CYP3A4 metabolizing enzyme. If this enzyme is inhibited, drugs metabolized by it may undergo slower metabolism, potentially leading to (in many cases) higher-than-normal drug levels. Elevated drug levels can increase the risk of experiencing side effects. However, it's important to point out that there is no documented or reported instance of this specific interaction occurring in human studies.
Severity Minor Likelihood Unlikely Evidence D

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist for Apadaz (benzhydrocodone with acetaminophen): the grape seed extract in these chews may gently slow down CYP3A4, one of the liver enzymes that helps process the opioid part of this medicine. If that enzyme works a bit slower, you could in theory end up with slightly higher opioid levels in your system. With an opioid, that might mean more pronounced drowsiness, dizziness, constipation, or slowed breathing.

That said, I don't want to alarm you. This is rated a minor, unlikely interaction based only on lab studies, with no real reports in people. Still, opioids deserve respect, so it's worth a quick chat with your pharmacist or doctor before pairing them, especially when you're first starting the medication.

Contact Dr. Brian directly if you have additional questions on this interaction
Minor

Cytochrome P450 2E1 (Cyp2E1) Substrates

3 of 4

Benzhydrocodone, Acetaminophen also falls under Cytochrome P450 2E1 (Cyp2E1) Substrates.

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews). Laboratory studies suggest that grape seed extract might have inhibitory effects on the CYP2E1 metabolizing enzyme. If this enzyme is inhibited, drugs metabolized by it may undergo slower metabolism, potentially leading to (in many cases) higher-than-normal drug levels. Elevated drug levels can increase the risk of experiencing side effects. However, it's important to point out that there is no documented or reported instance of this specific interaction occurring in human studies.
Severity Minor Likelihood Unlikely Evidence D

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the connection with Apadaz (benzhydrocodone with acetaminophen). The acetaminophen part is partly handled by a liver enzyme called CYP2E1. In lab studies only, the grape seed extract in these beet chews appears to slow that enzyme down a little. In theory, slower breakdown could let some byproducts shift around, but this has never actually been seen happen in real people, and the effect is rated minor and unlikely.

Practically speaking, taking these chews now and then is very unlikely to cause a problem with your pain medicine. The bigger thing to watch with any acetaminophen product is simply not going over the daily limit and avoiding extra alcohol. If you use Apadaz regularly, just run the supplement by your pharmacist or doctor first.

Contact Dr. Brian directly if you have additional questions on this interaction
Minor

Cytochrome P450 2E1 (Cyp2E1) Substrates

4 of 4

Benzhydrocodone, Acetaminophen also falls under Cytochrome P450 2E1 (Cyp2E1) Substrates.

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews). Laboratory studies suggest that grape seed extract might have inhibitory effects on the CYP2E1 metabolizing enzyme. If this enzyme is inhibited, drugs metabolized by it may undergo slower metabolism, potentially leading to (in many cases) higher-than-normal drug levels. Elevated drug levels can increase the risk of experiencing side effects. However, it's important to point out that there is no documented or reported instance of this specific interaction occurring in human studies.
Severity Minor Likelihood Unlikely Evidence D

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist with Apadaz (benzhydrocodone with acetaminophen). The grape seed extract in these chews may, at least in lab testing, gently slow down an enzyme called CYP2E1. That enzyme is one of the pathways your liver uses to handle the acetaminophen portion of this medicine. In theory, slower clearance could nudge levels a little higher.

Honestly though, this is a very low concern. The evidence is weak (lab studies only), there are no real human reports, and it's rated minor and unlikely. If anything, watch for the usual opioid effects like drowsiness, constipation, or nausea, but I wouldn't expect trouble at normal doses. Since this combo contains acetaminophen, just be mindful of your total daily acetaminophen. When in doubt, check with your pharmacist or doctor.

Contact Dr. Brian directly if you have additional questions on this interaction

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Humann Superbeets Heart Chews Also Interacts With Other Medications

Humann Superbeets Heart Chews has 893 minor known drug interactions in our database — the Benzhydrocodone, Acetaminophen one above is among them. If you take anything else, check it against the full list below.

Minor 893 No known interaction 1,937 (incl. Benzhydrocodone, Acetaminophen)
Taking anything else?

Check Another of Your Medications Against Humann Superbeets Heart Chews

Covers the 2,830 medications we’ve checked against Humann Superbeets Heart Chews. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Benzhydrocodone, Acetaminophen

This page covers Humann Superbeets Heart Chews only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Benzhydrocodone, Acetaminophen page lists 299 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Gamma-hydroxybutyrate (ghb) (major).

By severity: 14 major · 239 moderate · 46 minor.

Open the Benzhydrocodone, Acetaminophen interaction page

How much people look this up

Where Humann Superbeets Heart Chews and Benzhydrocodone, Acetaminophen Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Humann Superbeets Heart Chews
Top half

#623 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Benzhydrocodone, Acetaminophen
Top 25%

#515 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Humann Superbeets Heart Chews

What is Humann Superbeets Heart Chews?

Humann Superbeets Heart Chews
  • Heart and cardiovascular support
  • Healthy blood pressure support
  • Nitric oxide and blood flow support
  • Antioxidant support
  • Energy and circulation

SuperBeets Heart Chews are a beetroot- and grape-seed-based supplement marketed to support healthy blood flow, blood pressure, and nitric oxide production. Some research on dietary nitrate from beets and on grape seed extract suggests modest cardiovascular benefits, but evidence for this specific product is limited. It is generally well tolerated, but talk with your pharmacist or doctor before using it, especially if you have heart problems or take blood pressure medicine.

Read the full Humann Superbeets Heart Chews monograph & all interactions
Medication

About Benzhydrocodone and Acetaminophen

What Is Benzhydrocodone and Acetaminophen Used For?

Brand name: Apadaz

Apadaz is indicated for the short-term management of acute pain — specifically pain severe enough to require an opioid analgesic and for which other treatments are inadequate. It is approved for use for no more than 14 days.

Apadaz is reserved for patients who have not been able to tolerate non-opioid pain relievers, or for whom those options have not provided adequate pain relief. It should not be used long-term unless pain remains severe and alternative treatments continue to be insufficient.

See full Benzhydrocodone and Acetaminophen drug information
Keep checking

Other Drugs & Humann Superbeets Heart Chews

Browse every other medication we’ve checked against Humann Superbeets Heart Chews — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
893Minor
1,936No known interaction
893 Minor 1,936 No interaction
Minor

893 interactions

Showing 60 of 893 minor interactions — see all 893 on the Humann Superbeets Heart Chews page.

No interaction 1,936 drugs checked — show the list

We also checked Humann Superbeets Heart Chews against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,936 medications checked with no known interaction — see the full Humann Superbeets Heart Chews list.

See the full Humann Superbeets Heart Chews interactions page
See every supplement checked against Benzhydrocodone, Acetaminophen, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Humann Superbeets Heart Chews monograph › Uses, safety, and every drug interaction in one place Benzhydrocodone, Acetaminophen supplement interactions › Every supplement checked against Benzhydrocodone, Acetaminophen, ranked by severity Benzhydrocodone and Acetaminophen drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Humann Superbeets Heart Chews and Benzhydrocodone, Acetaminophen Together: Common Questions

Can you take Humann Superbeets Heart Chews with Benzhydrocodone, Acetaminophen?
There is only a minor interaction, which is usually not serious. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 4 interactions listed for Humann Superbeets Heart Chews and Benzhydrocodone, Acetaminophen?
Benzhydrocodone, Acetaminophen belongs to more than one drug category, and Humann Superbeets Heart Chews interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Humann Superbeets Heart Chews and Benzhydrocodone, Acetaminophen interaction?
We rate it Minor. This interaction is generally not clinically significant, but it remains worth noting and discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Benzhydrocodone, Acetaminophen and Humann Superbeets Heart Chews?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.