Drug & supplement interaction

Humann Superbeets Heart Chews + Acetaminophen, Hydrocodone

Acetaminophen, Hydrocodone brand names: Vicodin, Vicodin ES, Vicodin HP, Lortab, Norco 10/325, and others.

Minor Interaction
Medically reviewed by · Updated November 2023
The bottom line Minor

Acetaminophen, Hydrocodone falls into 4 drug categories that Humann Superbeets Heart Chews can interact with; the most serious is rated minor. Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Read the full interaction report
SeverityMinor
LikelihoodUnlikely
Interactions4
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Humann Superbeets Heart Chews and Acetaminophen, Hydrocodone

These two interact in 4 distinct ways. Each one is explained separately below.

Why Are There 4 Interactions?

Humann Superbeets Heart Chews interacts with whole categories of medication. Acetaminophen, Hydrocodone falls into 4 of those categories, so it can interact with Humann Superbeets Heart Chews in 4 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Minor).

Minor

Cytochrome P450 2D6 (Cyp2D6) Substrates

1 of 4

Why this applies to Acetaminophen, Hydrocodone

Acetaminophen, Hydrocodone falls under Cytochrome P450 2D6 (Cyp2D6) Substrates — the group Humann Superbeets Heart Chews interacts with.

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews). Laboratory studies suggest that grape seed extract might have inhibitory effects on the CYP2D6 metabolizing enzyme. If this enzyme is inhibited, drugs metabolized by it may undergo slower metabolism, potentially leading to (in many cases) higher-than-normal drug levels. Elevated drug levels can increase the risk of experiencing side effects. However, it's crucial to highlight that, as of now, there is no documented or reported instance of this specific interaction occurring in human studies.
Severity Minor Likelihood Unlikely Evidence D

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the interesting wrinkle with this combo. Hydrocodone is actually a prodrug for part of its pain relief. Your body uses the CYP2D6 enzyme to turn some of it into hydromorphone, a stronger painkiller. The grape seed extract in SuperBeets chews might mildly block CYP2D6 in lab tests, so in theory you could make a little less of that active form and get slightly less pain control.

In real life, this is very unlikely to matter. The evidence is weak (just lab studies, never reported in people), the amount of grape seed extract is small, and hydrocodone still works through other pathways. I wouldn't lose sleep over it. If you notice your pain medicine seems less effective, just mention it to your pharmacist or doctor rather than changing anything yourself.

Contact Dr. Brian directly if you have additional questions on this interaction
Minor

Cytochrome P450 3A4 (Cyp3A4) Substrates

2 of 4

Acetaminophen, Hydrocodone also falls under Cytochrome P450 3A4 (Cyp3A4) Substrates.

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews). Laboratory studies suggest that grape seed extract might have inhibitory effects on the CYP3A4 metabolizing enzyme. If this enzyme is inhibited, drugs metabolized by it may undergo slower metabolism, potentially leading to (in many cases) higher-than-normal drug levels. Elevated drug levels can increase the risk of experiencing side effects. However, it's important to point out that there is no documented or reported instance of this specific interaction occurring in human studies.
Severity Minor Likelihood Unlikely Evidence D

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist for your Norco or Vicodin (the acetaminophen and hydrocodone combo). The grape seed extract in these chews might gently slow down CYP3A4, one of the liver enzymes that helps break hydrocodone down. In theory, if that enzyme works a little slower, hydrocodone could hang around longer and feel a touch stronger, meaning more drowsiness, dizziness, constipation, or nausea.

That said, I want to keep this in perspective. This is based only on lab studies, not real people, and it's rated as a minor and unlikely interaction. For most folks, two chews a day won't cause a noticeable problem. Still, if you ever feel extra sleepy or foggy, mention it to your pharmacist or doctor before changing anything.

Contact Dr. Brian directly if you have additional questions on this interaction
Minor

Cytochrome P450 2E1 (Cyp2E1) Substrates

3 of 4

Acetaminophen, Hydrocodone also falls under Cytochrome P450 2E1 (Cyp2E1) Substrates.

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews). Laboratory studies suggest that grape seed extract might have inhibitory effects on the CYP2E1 metabolizing enzyme. If this enzyme is inhibited, drugs metabolized by it may undergo slower metabolism, potentially leading to (in many cases) higher-than-normal drug levels. Elevated drug levels can increase the risk of experiencing side effects. However, it's important to point out that there is no documented or reported instance of this specific interaction occurring in human studies.
Severity Minor Likelihood Unlikely Evidence D

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist for your Norco (acetaminophen and hydrocodone). The grape seed extract in SuperBeets chews may, in lab dishes, mildly block an enzyme called CYP2E1. That enzyme matters mostly for acetaminophen, because it helps create a toxic byproduct when acetaminophen is broken down. So in theory, slowing that pathway could actually shift how acetaminophen is processed, but this is test-tube science, not something seen in real people.

Practically, I wouldn't lose sleep over it. The evidence here is weak and no human cases have been reported. That said, keep your acetaminophen total under safe daily limits, and check in with your pharmacist or doctor before adding these chews, especially since hydrocodone causes drowsiness and constipation on its own.

Contact Dr. Brian directly if you have additional questions on this interaction
Minor

Cytochrome P450 2E1 (Cyp2E1) Substrates

4 of 4

Acetaminophen, Hydrocodone also falls under Cytochrome P450 2E1 (Cyp2E1) Substrates.

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews). Laboratory studies suggest that grape seed extract might have inhibitory effects on the CYP2E1 metabolizing enzyme. If this enzyme is inhibited, drugs metabolized by it may undergo slower metabolism, potentially leading to (in many cases) higher-than-normal drug levels. Elevated drug levels can increase the risk of experiencing side effects. However, it's important to point out that there is no documented or reported instance of this specific interaction occurring in human studies.
Severity Minor Likelihood Unlikely Evidence D

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist for your Norco (acetaminophen with hydrocodone). The grape seed extract in SuperBeets Heart Chews might gently slow down an enzyme called CYP2E1. That enzyme matters for acetaminophen mainly because it helps form a small toxic byproduct, so in theory, slowing it could actually mean slightly less of that harmful breakdown product, not more. The hydrocodone side is handled by different enzymes, so the chews aren't likely to change your pain relief.

The honest truth is this is a minor, theoretical concern built on lab studies, with no real-world cases reported. I wouldn't lose sleep over it. Just keep your acetaminophen under the daily limit, go easy on alcohol, and check with your pharmacist if you have questions.

Contact Dr. Brian directly if you have additional questions on this interaction

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Humann Superbeets Heart Chews Also Interacts With Other Medications

Humann Superbeets Heart Chews has 893 minor known drug interactions in our database — the Acetaminophen, Hydrocodone one above is among them. If you take anything else, check it against the full list below.

Minor 893 No known interaction 1,937 (incl. Acetaminophen, Hydrocodone)
Taking anything else?

Check Another of Your Medications Against Humann Superbeets Heart Chews

Covers the 2,830 medications we’ve checked against Humann Superbeets Heart Chews. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Acetaminophen, Hydrocodone

This page covers Humann Superbeets Heart Chews only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Acetaminophen, Hydrocodone page lists 270 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Gamma-hydroxybutyrate (ghb) (major).

By severity: 11 major · 215 moderate · 44 minor.

From our pharmacist’s overview on the Acetaminophen, Hydrocodone page

“Someone taking hydrocodone with acetaminophen (Vicodin, Norco) for post-surgical or dental pain often reaches for a sleep aid, kava, or a glass of wine at night, and that is exactly where the risk sits. This combination calls for genuine vigilance.”

Reviewed by 2 · Jul 18, 2026

Open the Acetaminophen, Hydrocodone interaction page

How much people look this up

Where Humann Superbeets Heart Chews and Acetaminophen, Hydrocodone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Humann Superbeets Heart Chews
Steady interest

#863 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Acetaminophen, Hydrocodone
Top 25%

#579 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Humann Superbeets Heart Chews

What is Humann Superbeets Heart Chews?

Humann Superbeets Heart Chews
  • Heart and cardiovascular support
  • Healthy blood pressure support
  • Nitric oxide and blood flow support
  • Antioxidant support
  • Energy and circulation

SuperBeets Heart Chews are a beetroot- and grape-seed-based supplement marketed to support healthy blood flow, blood pressure, and nitric oxide production. Some research on dietary nitrate from beets and on grape seed extract suggests modest cardiovascular benefits, but evidence for this specific product is limited. It is generally well tolerated, but talk with your pharmacist or doctor before using it, especially if you have heart problems or take blood pressure medicine.

Read the full Humann Superbeets Heart Chews monograph & all interactions
Keep checking

Other Drugs & Humann Superbeets Heart Chews

Browse every other medication we’ve checked against Humann Superbeets Heart Chews — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
893Minor
1,936No known interaction
893 Minor 1,936 No interaction
Minor

893 interactions

Showing 60 of 893 minor interactions — see all 893 on the Humann Superbeets Heart Chews page.

No interaction 1,936 drugs checked — show the list

We also checked Humann Superbeets Heart Chews against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,936 medications checked with no known interaction — see the full Humann Superbeets Heart Chews list.

See the full Humann Superbeets Heart Chews interactions page
See every supplement checked against Acetaminophen, Hydrocodone, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Humann Superbeets Heart Chews monograph › Uses, safety, and every drug interaction in one place Acetaminophen, Hydrocodone supplement interactions › Every supplement checked against Acetaminophen, Hydrocodone, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Humann Superbeets Heart Chews and Acetaminophen, Hydrocodone Together: Common Questions

Can you take Humann Superbeets Heart Chews with Acetaminophen, Hydrocodone?
There is only a minor interaction, which is usually not serious. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 4 interactions listed for Humann Superbeets Heart Chews and Acetaminophen, Hydrocodone?
Acetaminophen, Hydrocodone belongs to more than one drug category, and Humann Superbeets Heart Chews interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Humann Superbeets Heart Chews and Acetaminophen, Hydrocodone interaction?
We rate it Minor. This interaction is generally not clinically significant, but it remains worth noting and discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.