Lofexidine

Generic name: Pronounced as (loe fex' i deen)
Brand names
  • Lucemyra®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 08/15/2018

Lofexidine is used to manage opioid withdrawal symptoms (e.g., sick feeling, stomach cramps, muscle spasms or twitching, cold sensation, heart pounding, muscle tension, aches and pains, yawning, runny eyes, or difficulty falling asleep or staying asleep) that may occur after an opioid medication is suddenly stopped. Lofexidine is in a class of medications called central alpha adrenergic agonists. It works by relaxing blood vessels so that blood can flow more easily through the body.

Lofexidine comes as a tablet to take by mouth. It is usually taken with or without food four times a day (5 to 6 hours between each dose) to manage withdrawal symptoms after your last use of an opioid medication. It may be taken for up to 14 days depending on your symptoms and side effects. Take lofexidine at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take lofexidine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor may need to reduce, interrupt, or discontinue your treatment if you experience certain side effects. Talk to your doctor about how you are feeling during your treatment.

Lofexidine helps to reduce the severity of opioid withdrawal symptoms but may not completely prevent them. Do not stop taking lofexidine without talking to your doctor. If you suddenly stop taking lofexidine, your blood pressure may increase or you may experience withdrawal symptoms such as diarrhea, difficulty falling asleep or staying asleep, anxiety, chills, sweating, and leg or arm pain. Your doctor will probably tell you to decrease your dose gradually over 2 to 4 days.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking lofexidine,

  • tell your doctor and pharmacist if you are allergic to lofexidine, any other medications, or any of the ingredients in lofexidine tablets. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: amitriptyline; antidepressants; antifungals such as ketoconazole, itraconazole (Onmel, Sporanox), or voriconazole (Vfend); medications for anxiety; barbiturates such as phenobarbital (Luminal); benzodiazepines such as alprazolam (Xanax), lorazepam (Ativan), and triazolam (Halcion); clarithromycin (Biaxin, in Prevpac); erythromycin (E.E.S., E-Mycin, Erythrocin); granisetron (Kytril); haloperidol (Haldol); medications for high blood pressure; certain medications for human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) such as atazanavir (Reyataz), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), and saquinavir (Invirase); certain medications for irregular heartbeat such as amiodarone (Pacerone), disopyramide (Norpace), dofetilide (Tikosyn), procainamide, quinidine, and sotalol (Betapace, Betapace AF, Sotylize); medications for mental illness; methadone (Dolophine, Methadose); naltrexone (Vivitrol) when given by mouth; ondansetron (Zofran); pain medications; paroxetine (Brisdelle, Paxil, Pexeva); sedatives; sleeping pills; and tranquilizers. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you or anyone in your family has or has ever had long QT syndrome (condition that increases the risk of developing an irregular heartbeat that may cause fainting or sudden death), or another type of irregular heartbeat or heart rhythm problem, or if you have or have ever had low blood levels of magnesium or potassium in your blood, a heart attack, heart failure, low or high blood pressure, cerebrovascular disease (clogging or weakening of the blood vessels within the brain or leading to the brain), or heart, liver, or kidney disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking lofexidine, call your doctor.

  • you should know that lofexidine may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.

  • ask your doctor about the safe use of alcoholic beverages while you are taking lofexidine. Alcohol can make the side effects from lofexidine worse.

  • you should know that lofexidine may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up. If you experience these symptoms, sit or lie down. If these symptoms do not improve, call your doctor.

  • you should know that you may faint if you become dehydrated or overheated during your treatment with lofexidine. Be sure to drink plenty of liquids and stay cool while you are taking this medication.

  • you should know that after a period of not using opioid drugs, you may be more sensitive to the effects of opioids and are at a greater risk of overdosing if you were to take or use too much.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose as soon as you remember it. Then resume taking your next dose (5 to 6 hours later). Do not take a double dose to make up for a missed one.

  • Lofexidine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • difficulty falling asleep or staying asleep

    • dry mouth

    • ringing in the ears

  • Some side effects can be serious. If you experience any of these symptoms or those listed in the SPECIAL PRECAUTIONS section, call your doctor immediately or get emergency medical treatment:

    • fainting

    • dizziness or lightheadedness

  • Lofexidine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Do not remove the desiccant (drying agent) from the bottle.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

  • faintness

  • sedation

Keep all appointments with your doctor. Your doctor may order certain lab tests to check your body's response to lofexidine.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Moxifloxacin Moxifloxacin The metabolism of Lofexidine can be decreased when combined with Moxifloxacin.
Insulin Glargine (rDNA origin) Injection Insulin Glargine (rDNA origin) Injection The metabolism of Lofexidine can be increased when combined with Insulin glargine.
Leflunomide Leflunomide The serum concentration of Lofexidine can be decreased when it is combined with Leflunomide.
Delavirdine Delavirdine The metabolism of Lofexidine can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Lofexidine can be decreased when combined with Nevirapine.
Dolasetron Dolasetron The therapeutic efficacy of Dolasetron can be increased when used in combination with Lofexidine.
Aminophylline Aminophylline The metabolism of Lofexidine can be decreased when combined with Aminophylline.
Anagrelide Anagrelide The risk or severity of QTc prolongation can be increased when Lofexidine is combined with Anagrelide.
Candesartan Candesartan Lofexidine may decrease the antihypertensive activities of Candesartan.
Cilostazol Cilostazol The metabolism of Lofexidine can be decreased when combined with Cilostazol.
Clopidogrel Clopidogrel The metabolism of Lofexidine can be decreased when combined with Clopidogrel.
Diphenoxylate Diphenoxylate The therapeutic efficacy of Diphenoxylate can be increased when used in combination with Lofexidine.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The risk or severity of QTc prolongation can be increased when Erythromycin is combined with Lofexidine.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) The metabolism of Lofexidine can be decreased when combined with Conjugated estrogens.
Fenofibrate Fenofibrate Fenofibrate may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Guanfacine Guanfacine The therapeutic efficacy of Guanfacine can be increased when used in combination with Lofexidine.
Magnesium Hydroxide Magnesium Hydroxide Lofexidine may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Methylergonovine Methylergonovine Methylergometrine may increase the hypertensive and vasoconstricting activities of Lofexidine.
Mycophenolate Mycophenolate Mycophenolic acid may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Naratriptan Naratriptan The therapeutic efficacy of Naratriptan can be increased when used in combination with Lofexidine.
Olsalazine Olsalazine The therapeutic efficacy of Lofexidine can be decreased when used in combination with Olsalazine.
Paregoric Paregoric The therapeutic efficacy of Morphine can be increased when used in combination with Lofexidine.
Penbutolol Penbutolol The therapeutic efficacy of Lofexidine can be decreased when used in combination with Acebutolol.
Pentazocine Pentazocine The therapeutic efficacy of Pentazocine can be increased when used in combination with Lofexidine.
Potassium Potassium Potassium cation may increase the excretion rate of Lofexidine which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone Prednisone Prednisone may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Ranitidine Ranitidine The metabolism of Lofexidine can be decreased when combined with Ranitidine.
Reserpine Reserpine The therapeutic efficacy of Reserpine can be increased when used in combination with Lofexidine.
Rizatriptan Rizatriptan The therapeutic efficacy of Rizatriptan can be increased when used in combination with Lofexidine.
Sumatriptan Sumatriptan The therapeutic efficacy of Sumatriptan can be increased when used in combination with Lofexidine.
Tacrolimus Tacrolimus Tacrolimus may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Tizanidine Tizanidine The risk or severity of adverse effects can be increased when Tizanidine is combined with Lofexidine.
Zolmitriptan Zolmitriptan The therapeutic efficacy of Zolmitriptan can be increased when used in combination with Lofexidine.
Ampicillin Injection Ampicillin Injection Ampicillin may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Doxycycline Injection Doxycycline Injection Doxycycline may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Famotidine Injection Famotidine Injection The risk or severity of QTc prolongation can be increased when Famotidine is combined with Lofexidine.
Fluconazole Injection Fluconazole Injection The risk or severity of QTc prolongation can be increased when Fluconazole is combined with Lofexidine.
Foscarnet Injection Foscarnet Injection Foscarnet may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Hydromorphone Injection Hydromorphone Injection The therapeutic efficacy of Hydromorphone can be increased when used in combination with Lofexidine.
Interferon Beta-1b Injection Interferon Beta-1b Injection The metabolism of Lofexidine can be decreased when combined with Interferon beta-1b.
Interferon Gamma-1b Injection Interferon Gamma-1b Injection The metabolism of Lofexidine can be decreased when combined with Interferon gamma-1b.
Levofloxacin Injection Levofloxacin Injection The metabolism of Lofexidine can be decreased when combined with Levofloxacin.
Meperidine Injection Meperidine Injection The therapeutic efficacy of Meperidine can be increased when used in combination with Lofexidine.
Metoclopramide Injection Metoclopramide Injection The risk or severity of sedation can be increased when Metoclopramide is combined with Lofexidine.
Metronidazole Injection Metronidazole Injection The risk or severity of QTc prolongation can be increased when Metronidazole is combined with Lofexidine.
Morphine Injection Morphine Injection The therapeutic efficacy of Morphine can be increased when used in combination with Lofexidine.
Pamidronate Injection Pamidronate Injection Pamidronic acid may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Vancomycin Injection Vancomycin Injection Lofexidine may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Altretamine Altretamine The therapeutic efficacy of Amphetamine can be increased when used in combination with Lofexidine.
Cefuroxime Cefuroxime Cefuroxime may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Cyclosporine Cyclosporine The metabolism of Lofexidine can be decreased when combined with Cyclosporine.
Ondansetron Ondansetron The therapeutic efficacy of Ondansetron can be increased when used in combination with Lofexidine.
Granisetron Granisetron The therapeutic efficacy of Granisetron can be increased when used in combination with Lofexidine.
Torsemide Torsemide Torasemide may increase the excretion rate of Lofexidine which could result in a lower serum level and potentially a reduction in efficacy.
Olanzapine Olanzapine The therapeutic efficacy of Olanzapine can be increased when used in combination with Lofexidine.
Alosetron Alosetron The therapeutic efficacy of Alosetron can be increased when used in combination with Lofexidine.
Dofetilide Dofetilide The risk or severity of QTc prolongation can be increased when Lofexidine is combined with Dofetilide.
Entacapone Entacapone The therapeutic efficacy of Entacapone can be increased when used in combination with Lofexidine.
Eprosartan Eprosartan Eprosartan may decrease the antihypertensive activities of Lofexidine.
Hydroxychloroquine Hydroxychloroquine The metabolism of Lofexidine can be decreased when combined with Hydroxychloroquine.
Meloxicam Meloxicam The therapeutic efficacy of Lofexidine can be decreased when used in combination with Meloxicam.
Oxcarbazepine Oxcarbazepine The therapeutic efficacy of Oxcarbazepine can be increased when used in combination with Lofexidine.
Pantoprazole Pantoprazole Pantoprazole may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Telmisartan Telmisartan Telmisartan may decrease the antihypertensive activities of Lofexidine.
Temozolomide Temozolomide Temozolomide may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Zaleplon Zaleplon The therapeutic efficacy of Zaleplon can be increased when used in combination with Lofexidine.
Anakinra Anakinra The metabolism of Lofexidine can be increased when combined with Anakinra.
Desloratadine Desloratadine The therapeutic efficacy of Desloratadine can be increased when used in combination with Lofexidine.
Linezolid Linezolid The risk or severity of serotonin syndrome can be increased when Linezolid is combined with Lofexidine.
Trimipramine Trimipramine The therapeutic efficacy of Trimipramine can be increased when used in combination with Lofexidine.
Etanercept Injection Etanercept Injection The metabolism of Lofexidine can be increased when combined with Etanercept.
Glycopyrrolate Glycopyrrolate Lofexidine may increase the central nervous system depressant (CNS depressant) activities of Glycopyrronium.
Modafinil Modafinil The metabolism of Lofexidine can be increased when combined with Modafinil.
Perindopril Perindopril Perindopril may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Tenofovir Tenofovir Tenofovir may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate The therapeutic efficacy of Lofexidine can be decreased when used in combination with Choline magnesium trisalicylate.
Dutasteride Dutasteride The risk or severity of hypertension can be increased when Dutasteride is combined with Lofexidine.
Epinephrine Injection Epinephrine Injection The risk or severity of hypertension can be increased when Epinephrine is combined with Lofexidine.
Eplerenone Eplerenone Eplerenone may increase the excretion rate of Lofexidine which could result in a lower serum level and potentially a reduction in efficacy.
Escitalopram Escitalopram The therapeutic efficacy of Escitalopram can be increased when used in combination with Lofexidine.
Olmesartan Olmesartan Olmesartan may decrease the antihypertensive activities of Lofexidine.
Zonisamide Zonisamide The therapeutic efficacy of Zonisamide can be increased when used in combination with Lofexidine.
Adalimumab Injection Adalimumab Injection The metabolism of Lofexidine can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The therapeutic efficacy of Aripiprazole can be increased when used in combination with Lofexidine.
Atomoxetine Atomoxetine The therapeutic efficacy of Atomoxetine can be increased when used in combination with Lofexidine.
Dexmethylphenidate Dexmethylphenidate The therapeutic efficacy of Dexmethylphenidate can be increased when used in combination with Lofexidine.
Atazanavir Atazanavir Atazanavir may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Almotriptan Almotriptan The therapeutic efficacy of Almotriptan can be increased when used in combination with Lofexidine.
Eletriptan Eletriptan The therapeutic efficacy of Eletriptan can be increased when used in combination with Lofexidine.
Mefloquine Mefloquine The risk or severity of QTc prolongation can be increased when Mefloquine is combined with Lofexidine.
Vardenafil Vardenafil The risk or severity of QTc prolongation can be increased when Vardenafil is combined with Lofexidine.
Alfuzosin Alfuzosin Alfuzosin may increase the hypotensive activities of Lofexidine.
Emtricitabine Emtricitabine The excretion of Emtricitabine can be decreased when combined with Lofexidine.
Interferon Beta-1a Subcutaneous Injection Interferon Beta-1a Subcutaneous Injection The metabolism of Lofexidine can be decreased when combined with Interferon beta-1a.
Memantine Memantine Memantine may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Tegaserod Tegaserod The metabolism of Lofexidine can be decreased when combined with Tegaserod.
Tadalafil Tadalafil Tadalafil may increase the antihypertensive activities of Lofexidine.
Frovatriptan Frovatriptan The therapeutic efficacy of Frovatriptan can be increased when used in combination with Lofexidine.
Gemifloxacin Gemifloxacin The metabolism of Lofexidine can be decreased when combined with Gemifloxacin.
Progesterone Progesterone The metabolism of Lofexidine can be decreased when combined with Progesterone.
Apomorphine Injection Apomorphine Injection The therapeutic efficacy of Apomorphine can be increased when used in combination with Lofexidine.
Infliximab Injection Infliximab Injection The metabolism of Lofexidine can be increased when combined with Infliximab.
Protriptyline Protriptyline The therapeutic efficacy of Protriptyline can be increased when used in combination with Lofexidine.
Duloxetine Duloxetine The therapeutic efficacy of Duloxetine can be increased when used in combination with Lofexidine.
Tinidazole Tinidazole Tinidazole may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Trospium Trospium Lofexidine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Bosentan Bosentan Lofexidine may decrease the antihypertensive activities of Bosentan.
Cefditoren Cefditoren Cefdinir may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Cinacalcet Cinacalcet The metabolism of Lofexidine can be decreased when combined with Cinacalcet.
Cyanocobalamin Injection Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Erlotinib Erlotinib The metabolism of Erlotinib can be decreased when combined with Lofexidine.
Eszopiclone Eszopiclone The therapeutic efficacy of Eszopiclone can be increased when used in combination with Lofexidine.
Ganciclovir Ganciclovir The excretion of Ganciclovir can be decreased when combined with Lofexidine.
Ribavirin Ribavirin Ribavirin may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Solifenacin Solifenacin The risk or severity of QTc prolongation can be increased when Solifenacin is combined with Lofexidine.
Valganciclovir Valganciclovir Valganciclovir may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Voriconazole Voriconazole The risk or severity of QTc prolongation can be increased when Voriconazole is combined with Lofexidine.
Adefovir Adefovir Adefovir may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Dextroamphetamine Dextroamphetamine The therapeutic efficacy of Amphetamine can be increased when used in combination with Lofexidine.
Entecavir Entecavir The metabolism of Lofexidine can be decreased when combined with Entecavir.
Peginterferon Alfa-2a Injection Peginterferon Alfa-2a Injection The metabolism of Lofexidine can be decreased when combined with Peginterferon alfa-2a.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The serum concentration of Lofexidine can be increased when it is combined with Peginterferon alfa-2b.
Sodium Oxybate Sodium Oxybate The therapeutic efficacy of Sodium oxybate can be increased when used in combination with Lofexidine.
Ibandronate Ibandronate The risk or severity of QTc prolongation can be increased when Ibandronate is combined with Lofexidine.
Isocarboxazid Isocarboxazid The therapeutic efficacy of Isocarboxazid can be increased when used in combination with Lofexidine.
Ramelteon Ramelteon The therapeutic efficacy of Ramelteon can be increased when used in combination with Lofexidine.
Darifenacin Darifenacin The metabolism of Lofexidine can be decreased when combined with Darifenacin.
Fentanyl Fentanyl The therapeutic efficacy of Fentanyl can be increased when used in combination with Lofexidine.
Pregabalin Pregabalin The therapeutic efficacy of Pregabalin can be increased when used in combination with Lofexidine.
Deferasirox Deferasirox The serum concentration of Lofexidine can be increased when it is combined with Deferasirox.
Phenylephrine Phenylephrine The metabolism of Lofexidine can be increased when combined with Phenylephrine.
Tipranavir Tipranavir The metabolism of Lofexidine can be decreased when combined with Tipranavir.
Felbamate Felbamate The therapeutic efficacy of Felbamate can be increased when used in combination with Lofexidine.
Ranolazine Ranolazine The serum concentration of Lofexidine can be increased when it is combined with Ranolazine.
Abatacept Injection Abatacept Injection The metabolism of Lofexidine can be increased when combined with Abatacept.
Rasagiline Rasagiline The therapeutic efficacy of Rasagiline can be increased when used in combination with Lofexidine.
Imatinib Imatinib The risk or severity of QTc prolongation can be increased when Lofexidine is combined with Imatinib.
Sitagliptin Sitagliptin Sitagliptin may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Varenicline Varenicline Varenicline may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Gefitinib Gefitinib The metabolism of Lofexidine can be decreased when combined with Gefitinib.
Albuterol Albuterol The risk or severity of QTc prolongation can be increased when Salbutamol is combined with Lofexidine.
Paliperidone Paliperidone The therapeutic efficacy of Paliperidone can be increased when used in combination with Lofexidine.
Bortezomib Bortezomib The metabolism of Lofexidine can be decreased when combined with Bortezomib.
Clofarabine Injection Clofarabine Injection Clofarabine may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Insulin Glulisine (rDNA origin) Injection Insulin Glulisine (rDNA origin) Injection The metabolism of Lofexidine can be increased when combined with Insulin glulisine.
Lubiprostone Lubiprostone Lubiprostone may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Oxaliplatin Injection Oxaliplatin Injection The risk or severity of QTc prolongation can be increased when Oxaliplatin is combined with Lofexidine.
Posaconazole Posaconazole The risk or severity of QTc prolongation can be increased when Posaconazole is combined with Lofexidine.
Primaquine Primaquine The metabolism of Lofexidine can be decreased when combined with Primaquine.
Rituximab Injection Rituximab Injection Lofexidine may increase the hypotensive activities of Rituximab.
Aliskiren Aliskiren Lofexidine may decrease the antihypertensive activities of Aliskiren.
Pemetrexed Injection Pemetrexed Injection Lofexidine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Dimenhydrinate Dimenhydrinate The therapeutic efficacy of Dimenhydrinate can be increased when used in combination with Lofexidine.
Lisdexamfetamine Lisdexamfetamine The risk or severity of serotonin syndrome can be increased when Lisdexamfetamine is combined with Lofexidine.
Nabilone Nabilone The therapeutic efficacy of Nabilone can be increased when used in combination with Lofexidine.
Vorinostat Vorinostat The risk or severity of QTc prolongation can be increased when Vorinostat is combined with Lofexidine.
Sorafenib Sorafenib The metabolism of Lofexidine can be decreased when combined with Sorafenib.
Sunitinib Sunitinib The risk or severity of QTc prolongation can be increased when Sunitinib is combined with Lofexidine.
Dronabinol Dronabinol The therapeutic efficacy of Dronabinol can be increased when used in combination with Lofexidine.
Lapatinib Lapatinib The risk or severity of QTc prolongation can be increased when Lapatinib is combined with Lofexidine.
Levocetirizine Levocetirizine The therapeutic efficacy of Levocetirizine can be increased when used in combination with Lofexidine.
Pegaptanib Injection Pegaptanib Injection Pegaptanib may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Dasatinib Dasatinib The metabolism of Lofexidine can be decreased when combined with Dasatinib.
Mexiletine Mexiletine The metabolism of Lofexidine can be decreased when combined with Mexiletine.
Armodafinil Armodafinil The metabolism of Lofexidine can be increased when combined with Armodafinil.
Azacitidine Injection Azacitidine Injection Azacitidine may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Temsirolimus Temsirolimus The metabolism of Lofexidine can be decreased when combined with Temsirolimus.
Lenalidomide Lenalidomide Lenalidomide may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Nilotinib Nilotinib The metabolism of Nilotinib can be decreased when combined with Lofexidine.
Toremifene Toremifene The risk or severity of QTc prolongation can be increased when Lofexidine is combined with Toremifene.
Budesonide Budesonide Budesonide may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Desmopressin Desmopressin Desmopressin may decrease the excretion rate of Lofexidine which could result in a higher serum level.
OnabotulinumtoxinA Injection OnabotulinumtoxinA Injection The therapeutic efficacy of Botulinum toxin type A can be increased when used in combination with Lofexidine.
RimabotulinumtoxinB Injection RimabotulinumtoxinB Injection The therapeutic efficacy of Botulinum Toxin Type B can be increased when used in combination with Lofexidine.
Doripenem Injection Doripenem Injection Lofexidine may decrease the excretion rate of Doripenem which could result in a higher serum level.
Arsenic Trioxide Injection Arsenic Trioxide Injection The risk or severity of QTc prolongation can be increased when Lofexidine is combined with Arsenic trioxide.
Desvenlafaxine Desvenlafaxine The therapeutic efficacy of Desvenlafaxine can be increased when used in combination with Lofexidine.
Cevimeline Cevimeline Cevimeline may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Nebivolol Nebivolol The therapeutic efficacy of Lofexidine can be decreased when used in combination with Nebivolol.
Tretinoin Tretinoin The risk or severity of adverse effects can be increased when Tretinoin is combined with Lofexidine.
Bendamustine Injection Bendamustine Injection The metabolism of Bendamustine can be decreased when combined with Lofexidine.
Flecainide Flecainide The metabolism of Flecainide can be decreased when combined with Lofexidine.
Certolizumab Injection Certolizumab Injection The metabolism of Lofexidine can be increased when combined with Certolizumab pegol.
Daptomycin Injection Daptomycin Injection Daptomycin may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Praziquantel Praziquantel The metabolism of Lofexidine can be decreased when combined with Praziquantel.
Methylnaltrexone Injection Methylnaltrexone Injection Lofexidine may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level.
Rufinamide Rufinamide The therapeutic efficacy of Rufinamide can be increased when used in combination with Lofexidine.
Silodosin Silodosin The therapeutic efficacy of Lofexidine can be decreased when used in combination with Silodosin.
Midazolam Midazolam The therapeutic efficacy of Midazolam can be increased when used in combination with Lofexidine.
Naltrexone Injection Naltrexone Injection The bioavailability of Naltrexone can be decreased when combined with Lofexidine.
Dexrazoxane Injection Dexrazoxane Injection Dexrazoxane may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Eltrombopag Eltrombopag The metabolism of Eltrombopag can be decreased when combined with Lofexidine.
Milnacipran Milnacipran The therapeutic efficacy of Milnacipran can be increased when used in combination with Lofexidine.
Plerixafor Injection Plerixafor Injection Lofexidine may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Fesoterodine Fesoterodine Lofexidine may increase the central nervous system depressant (CNS depressant) activities of Fesoterodine.
Degarelix Injection Degarelix Injection The risk or severity of QTc prolongation can be increased when Degarelix is combined with Lofexidine.
Betaxolol Betaxolol The therapeutic efficacy of Lofexidine can be decreased when used in combination with Betaxolol.
Iloperidone Iloperidone The therapeutic efficacy of Iloperidone can be increased when used in combination with Lofexidine.
Prasugrel Prasugrel Lofexidine may decrease the excretion rate of Prasugrel which could result in a higher serum level.
Lacosamide Lacosamide The therapeutic efficacy of Lacosamide can be increased when used in combination with Lofexidine.
Everolimus Everolimus The metabolism of Lofexidine can be decreased when combined with Everolimus.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) Tolvaptan may increase the excretion rate of Lofexidine which could result in a lower serum level and potentially a reduction in efficacy.
Dronedarone Dronedarone The metabolism of Dronedarone can be decreased when combined with Lofexidine.
AbobotulinumtoxinA Injection AbobotulinumtoxinA Injection The therapeutic efficacy of Botulinum toxin type A can be increased when used in combination with Lofexidine.
Pralatrexate Injection Pralatrexate Injection Lofexidine may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Palonosetron Injection Palonosetron Injection The therapeutic efficacy of Palonosetron can be increased when used in combination with Lofexidine.
Saxagliptin Saxagliptin Lofexidine may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Telavancin Injection Telavancin Injection The risk or severity of QTc prolongation can be increased when Lofexidine is combined with Telavancin.
Romidepsin Injection Romidepsin Injection The risk or severity of QTc prolongation can be increased when Lofexidine is combined with Romidepsin.
Tapentadol Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Lofexidine.
Topotecan Topotecan The excretion of Topotecan can be decreased when combined with Lofexidine.
Golimumab Injection Golimumab Injection The metabolism of Lofexidine can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Pazopanib can be decreased when combined with Lofexidine.
Asenapine Asenapine The therapeutic efficacy of Asenapine can be increased when used in combination with Lofexidine.
Vigabatrin Vigabatrin The therapeutic efficacy of Vigabatrin can be increased when used in combination with Lofexidine.
Albendazole Albendazole The metabolism of Lofexidine can be decreased when combined with Albendazole.
Oxymorphone Oxymorphone The therapeutic efficacy of Oxymorphone can be increased when used in combination with Lofexidine.
Tocilizumab Injection Tocilizumab Injection The metabolism of Lofexidine can be increased when combined with Tocilizumab.
Dalfampridine Dalfampridine Lofexidine may decrease the excretion rate of Dalfampridine which could result in a higher serum level.
Eribulin Injection Eribulin Injection The risk or severity of QTc prolongation can be increased when Eribulin is combined with Lofexidine.
IncobotulinumtoxinA Injection IncobotulinumtoxinA Injection The therapeutic efficacy of Botulinum toxin type A can be increased when used in combination with Lofexidine.
Ceftaroline Injection Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Lurasidone Lurasidone The therapeutic efficacy of Lurasidone can be increased when used in combination with Lofexidine.
Acetaminophen Injection Acetaminophen Injection The metabolism of Lofexidine can be decreased when combined with Acetaminophen.
Vilazodone Vilazodone The therapeutic efficacy of Vilazodone can be increased when used in combination with Lofexidine.
Ipilimumab Injection Ipilimumab Injection Lofexidine may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Denileukin Diftitox Injection Denileukin Diftitox Injection Aldesleukin may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Terbutaline Injection Terbutaline Injection The risk or severity of QTc prolongation can be increased when Terbutaline is combined with Lofexidine.
Azilsartan Azilsartan The risk or severity of adverse effects can be increased when Azilsartan medoxomil is combined with Lofexidine.
Roflumilast Roflumilast Roflumilast may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Rilpivirine Rilpivirine The metabolism of Lofexidine can be decreased when combined with Rilpivirine.
Abiraterone Abiraterone The serum concentration of Lofexidine can be increased when it is combined with Abiraterone.
Triptorelin Injection Triptorelin Injection The risk or severity of QTc prolongation can be increased when Triptorelin is combined with Lofexidine.
Rivaroxaban Rivaroxaban Lofexidine may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Ruxolitinib Ruxolitinib Lofexidine may decrease the excretion rate of Ruxolitinib which could result in a higher serum level.
Vandetanib Vandetanib The risk or severity of QTc prolongation can be increased when Lofexidine is combined with Vandetanib.
Clobazam Clobazam The therapeutic efficacy of Clobazam can be increased when used in combination with Lofexidine.
Vemurafenib Vemurafenib The serum concentration of Lofexidine can be increased when it is combined with Vemurafenib.
Deferiprone Deferiprone Lofexidine may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Axitinib Axitinib The metabolism of Axitinib can be decreased when combined with Lofexidine.
Crizotinib Crizotinib The risk or severity of QTc prolongation can be increased when Lofexidine is combined with Crizotinib.
Cabergoline Cabergoline The therapeutic efficacy of Cabergoline can be increased when used in combination with Lofexidine.
Naloxone Injection Naloxone Injection Naloxone may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Ambrisentan Ambrisentan Lofexidine may decrease the antihypertensive activities of Ambrisentan.
Fondaparinux Injection Fondaparinux Injection Fondaparinux may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Ezogabine Ezogabine The therapeutic efficacy of Tiagabine can be increased when used in combination with Lofexidine.
Iloprost Iloprost Iloprost may increase the hypotensive activities of Lofexidine.
Enzalutamide Enzalutamide Lofexidine may decrease the excretion rate of Enzalutamide which could result in a higher serum level.
Mirabegron Mirabegron The metabolism of Mirabegron can be decreased when combined with Lofexidine.
Teriflunomide Teriflunomide The serum concentration of Lofexidine can be decreased when it is combined with Teriflunomide.
Teduglutide Injection Teduglutide Injection Lofexidine may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Bedaquiline Bedaquiline The risk or severity of QTc prolongation can be increased when Lofexidine is combined with Bedaquiline.
Alogliptin Alogliptin Lofexidine may decrease the excretion rate of Alogliptin which could result in a higher serum level.
Ponatinib Ponatinib The metabolism of Ponatinib can be decreased when combined with Lofexidine.
Pomalidomide Pomalidomide The therapeutic efficacy of Pomalidomide can be increased when used in combination with Lofexidine.
Canagliflozin Canagliflozin Lofexidine may increase the excretion rate of Canagliflozin which could result in a lower serum level and potentially a reduction in efficacy.
Methazolamide Methazolamide Methazolamide may increase the excretion rate of Lofexidine which could result in a lower serum level and potentially a reduction in efficacy.
Dabrafenib Dabrafenib The risk or severity of QTc prolongation can be increased when Dabrafenib is combined with Lofexidine.
Ospemifene Ospemifene The metabolism of Lofexidine can be decreased when combined with Ospemifene.
Trametinib Trametinib Lofexidine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Levomilnacipran Levomilnacipran The therapeutic efficacy of Levomilnacipran can be increased when used in combination with Lofexidine.
Ertapenem Injection Ertapenem Injection Ertapenem may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Vortioxetine Vortioxetine The therapeutic efficacy of Vortioxetine can be increased when used in combination with Lofexidine.
Perampanel Perampanel The therapeutic efficacy of Perampanel can be increased when used in combination with Lofexidine.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Lofexidine.
Avanafil Avanafil Avanafil may increase the antihypertensive activities of Lofexidine.
Ketorolac Injection Ketorolac Injection The therapeutic efficacy of Lofexidine can be decreased when used in combination with Ketorolac.
Obinutuzumab Injection Obinutuzumab Injection Lofexidine may increase the hypotensive activities of Obinutuzumab.
Simeprevir Simeprevir The metabolism of Lofexidine can be decreased when combined with Simeprevir.
Sofosbuvir Sofosbuvir Lofexidine may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin Dapagliflozin The metabolism of Lofexidine can be decreased when combined with Dapagliflozin.
Apremilast Apremilast The metabolism of Lofexidine can be increased when combined with Apremilast.
Droxidopa Droxidopa Lofexidine may decrease the excretion rate of Droxidopa which could result in a higher serum level.
Ceritinib Ceritinib The risk or severity of QTc prolongation can be increased when Lofexidine is combined with Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Lofexidine can be increased when combined with Siltuximab.
Eslicarbazepine Eslicarbazepine The therapeutic efficacy of Eslicarbazepine can be increased when used in combination with Lofexidine.
Belinostat Injection Belinostat Injection The metabolism of Lofexidine can be increased when combined with Belinostat.
Testosterone Injection Testosterone Injection Testosterone may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Oritavancin Injection Oritavancin Injection The metabolism of Lofexidine can be decreased when combined with Oritavancin.
Empagliflozin Empagliflozin The risk or severity of adverse effects can be increased when Empagliflozin is combined with Lofexidine.
Hydrocodone Hydrocodone The therapeutic efficacy of Hydrocodone can be increased when used in combination with Lofexidine.
Suvorexant Suvorexant The therapeutic efficacy of Suvorexant can be increased when used in combination with Lofexidine.
Edoxaban Edoxaban Lofexidine may decrease the excretion rate of Edoxaban which could result in a higher serum level.
Peginterferon Beta-1a Injection Peginterferon Beta-1a Injection The metabolism of Lofexidine can be decreased when combined with Peginterferon beta-1a.
Methamphetamine Methamphetamine The therapeutic efficacy of Metamfetamine can be increased when used in combination with Lofexidine.
Tasimelteon Tasimelteon The therapeutic efficacy of Tasimelteon can be increased when used in combination with Lofexidine.
Riociguat Riociguat Lofexidine may decrease the antihypertensive activities of Riociguat.
Pirfenidone Pirfenidone The metabolism of Pirfenidone can be decreased when combined with Lofexidine.
Secukinumab Injection Secukinumab Injection The metabolism of Lofexidine can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The therapeutic efficacy of Risperidone can be increased when used in combination with Lofexidine.
Insulin Human Inhalation Insulin Human Inhalation The metabolism of Lofexidine can be increased when combined with Insulin human.
Lenvatinib Lenvatinib The metabolism of Lofexidine can be decreased when combined with Lenvatinib.
Naloxegol Naloxegol The metabolism of Lofexidine can be decreased when combined with Naloxegol.
Panobinostat Panobinostat The metabolism of Lofexidine can be decreased when combined with Panobinostat.
Dinutuximab Injection Dinutuximab Injection The risk or severity of adverse effects can be increased when Dinutuximab is combined with Lofexidine.
Haloperidol Injection Haloperidol Injection The therapeutic efficacy of Haloperidol can be increased when used in combination with Lofexidine.
Ivabradine Ivabradine Ivabradine may increase the QTc-prolonging activities of Lofexidine.
Amiloride Amiloride Amiloride may increase the excretion rate of Lofexidine which could result in a lower serum level and potentially a reduction in efficacy.
Macitentan Macitentan Lofexidine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Flibanserin Flibanserin The therapeutic efficacy of Flibanserin can be increased when used in combination with Lofexidine.
Rolapitant Rolapitant The metabolism of Lofexidine can be decreased when combined with Rolapitant.
Brexpiprazole Brexpiprazole The therapeutic efficacy of Brexpiprazole can be increased when used in combination with Lofexidine.
Ziprasidone Injection Ziprasidone Injection The risk or severity of QTc prolongation can be increased when Lofexidine is combined with Ziprasidone.
Cariprazine Cariprazine The therapeutic efficacy of Cariprazine can be increased when used in combination with Lofexidine.
Penicillin G Procaine Injection Penicillin G Procaine Injection Lofexidine may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Eluxadoline Eluxadoline The risk or severity of serotonin syndrome can be increased when Lofexidine is combined with Eluxadoline.
Insulin Degludec (rDNA Origin) Injection Insulin Degludec (rDNA Origin) Injection The metabolism of Lofexidine can be increased when combined with Insulin degludec.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Lofexidine.
Osimertinib Osimertinib The serum concentration of Lofexidine can be decreased when it is combined with Osimertinib.
Ixazomib Ixazomib Lofexidine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Lesinurad Lesinurad Lofexidine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Brivaracetam Injection Brivaracetam Injection The therapeutic efficacy of Brivaracetam can be increased when used in combination with Lofexidine.
Cobicistat Cobicistat The metabolism of Lofexidine can be decreased when combined with Cobicistat.
Midodrine Midodrine Midodrine may decrease the antihypertensive activities of Lofexidine.
Selexipag Selexipag Lofexidine may decrease the antihypertensive activities of Selexipag.
Pimavanserin Pimavanserin The therapeutic efficacy of Pimavanserin can be increased when used in combination with Lofexidine.
Obeticholic Acid Obeticholic Acid The metabolism of Lofexidine can be decreased when combined with Obeticholic acid.
Diphenhydramine Injection Diphenhydramine Injection The therapeutic efficacy of Diphenhydramine can be increased when used in combination with Lofexidine.
Furosemide Injection Furosemide Injection Furosemide may increase the excretion rate of Lofexidine which could result in a lower serum level and potentially a reduction in efficacy.
Rucaparib Rucaparib The metabolism of Rucaparib can be decreased when combined with Lofexidine.
Lixisenatide Injection Lixisenatide Injection Lofexidine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Ribociclib Ribociclib The risk or severity of QTc prolongation can be increased when Lofexidine is combined with Ribociclib.
Doxepin (Insomnia) Doxepin (Insomnia) The therapeutic efficacy of Doxepin can be increased when used in combination with Lofexidine.
Deutetrabenazine Deutetrabenazine The risk or severity of QTc prolongation can be increased when Lofexidine is combined with Deutetrabenazine.
Valbenazine Valbenazine Lofexidine may decrease the excretion rate of Valbenazine which could result in a higher serum level.
Safinamide Safinamide The therapeutic efficacy of Safinamide can be increased when used in combination with Lofexidine.
Naldemedine Naldemedine Lofexidine may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Midostaurin Midostaurin The metabolism of Lofexidine can be decreased when combined with Midostaurin.
Enasidenib Enasidenib The metabolism of Lofexidine can be decreased when combined with Enasidenib.
Benznidazole Benznidazole Lofexidine may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Delafloxacin Delafloxacin The risk or severity of QTc prolongation can be increased when Delafloxacin is combined with Lofexidine.
Abemaciclib Abemaciclib The excretion of Abemaciclib can be decreased when combined with Lofexidine.
Letermovir Letermovir The metabolism of Letermovir can be decreased when combined with Lofexidine.
Tetrabenazine Tetrabenazine The risk or severity of QTc prolongation can be increased when Lofexidine is combined with Tetrabenazine.
Ertugliflozin Ertugliflozin Ertugliflozin may increase the excretion rate of Lofexidine which could result in a lower serum level and potentially a reduction in efficacy.
Buprenorphine Injection Buprenorphine Injection The therapeutic efficacy of Buprenorphine can be increased when used in combination with Lofexidine.
Apalutamide Apalutamide Lofexidine may decrease the excretion rate of Apalutamide which could result in a higher serum level.
Fostamatinib Fostamatinib Fostamatinib may increase the antihypertensive activities of Lofexidine.
Baricitinib Baricitinib Lofexidine may decrease the excretion rate of Baricitinib which could result in a higher serum level.
Plazomicin Injection Plazomicin Injection Lofexidine may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Eliglustat Eliglustat The risk or severity of QTc prolongation can be increased when Lofexidine is combined with Eliglustat.
Encorafenib Encorafenib The risk or severity of QTc prolongation can be increased when Lofexidine is combined with Encorafenib.
Binimetinib Binimetinib The metabolism of Binimetinib can be decreased when combined with Lofexidine.
Ivosidenib Ivosidenib The risk or severity of QTc prolongation can be increased when Lofexidine is combined with Ivosidenib.
Elagolix Elagolix The metabolism of Elagolix can be decreased when combined with Lofexidine.
Tafenoquine Tafenoquine The metabolism of Tafenoquine can be decreased when combined with Lofexidine.
Cannabidiol Cannabidiol The therapeutic efficacy of Cannabidiol can be increased when used in combination with Lofexidine.
Dacomitinib Dacomitinib The metabolism of Lofexidine can be decreased when combined with Dacomitinib.
Stiripentol Stiripentol The therapeutic efficacy of Stiripentol can be increased when used in combination with Lofexidine.
Gilteritinib Gilteritinib The therapeutic efficacy of Lofexidine can be decreased when used in combination with Gilteritinib.
Glasdegib Glasdegib The risk or severity of QTc prolongation can be increased when Lofexidine is combined with Glasdegib.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The risk or severity of adverse effects can be increased when Paclitaxel is combined with Lofexidine.
Rifamycin Rifamycin The metabolism of Lofexidine can be decreased when combined with Rifamycin.
Prucalopride Prucalopride Lofexidine may decrease the excretion rate of Prucalopride which could result in a higher serum level.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Lofexidine can be increased when combined with Emapalumab.
Siponimod Siponimod Siponimod may decrease the antihypertensive activities of Lofexidine.
Acyclovir Ophthalmic Acyclovir Ophthalmic Acyclovir may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Brexanolone Injection Brexanolone Injection The therapeutic efficacy of Brexanolone can be increased when used in combination with Lofexidine.
Solriamfetol Solriamfetol The therapeutic efficacy of Solriamfetol can be increased when used in combination with Lofexidine.
Triclabendazole Triclabendazole The risk or severity of QTc prolongation can be increased when Triclabendazole is combined with Lofexidine.
Entrectinib Entrectinib The risk or severity of QTc prolongation can be increased when Lofexidine is combined with Entrectinib.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Lofexidine.
Pitolisant Pitolisant Lofexidine may increase the QTc-prolonging activities of Pitolisant.
Fedratinib Fedratinib The metabolism of Lofexidine can be decreased when combined with Fedratinib.
Lefamulin Lefamulin Lefamulin may increase the QTc-prolonging activities of Lofexidine.
Phenytoin Injection Phenytoin Injection The therapeutic efficacy of Phenytoin can be increased when used in combination with Lofexidine.
Fosphenytoin Injection Fosphenytoin Injection The therapeutic efficacy of Fosphenytoin can be increased when used in combination with Lofexidine.
Lumateperone Lumateperone The therapeutic efficacy of Lumateperone can be increased when used in combination with Lofexidine.
Lasmiditan Lasmiditan The therapeutic efficacy of Lasmiditan can be increased when used in combination with Lofexidine.
Selumetinib Selumetinib The metabolism of Selumetinib can be decreased when combined with Lofexidine.
Selpercatinib Selpercatinib Selpercatinib may decrease the antihypertensive activities of Lofexidine.
Capmatinib Capmatinib The metabolism of Lofexidine can be decreased when combined with Capmatinib.
Lemborexant Lemborexant The therapeutic efficacy of Lemborexant can be increased when used in combination with Lofexidine.
Fenfluramine Fenfluramine The therapeutic efficacy of Fenfluramine can be increased when used in combination with Lofexidine.
Fostemsavir Fostemsavir The risk or severity of QTc prolongation can be increased when Fostemsavir is combined with Lofexidine.
Octreotide Octreotide The risk or severity of QTc prolongation can be increased when Octreotide is combined with Lofexidine.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Lofexidine can be decreased when it is combined with Satralizumab.
Naxitamab-gqgk Injection Naxitamab-gqgk Injection Naxitamab may decrease the antihypertensive activities of Lofexidine.
Relugolix Relugolix The risk or severity of QTc prolongation can be increased when Relugolix is combined with Lofexidine.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives Drospirenone may increase the excretion rate of Lofexidine which could result in a lower serum level and potentially a reduction in efficacy.
Viloxazine Viloxazine The therapeutic efficacy of Viloxazine can be increased when used in combination with Lofexidine.
Tobramycin Injection Tobramycin Injection Tobramycin may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Theophylline Theophylline The metabolism of Theophylline can be decreased when combined with Lofexidine.
Fenoprofen Fenoprofen The therapeutic efficacy of Lofexidine can be decreased when used in combination with Fenoprofen.
Indomethacin Indomethacin The therapeutic efficacy of Lofexidine can be decreased when used in combination with Indomethacin.
Mefenamic Acid Mefenamic Acid The therapeutic efficacy of Lofexidine can be decreased when used in combination with Mefenamic acid.
Naproxen Naproxen The therapeutic efficacy of Lofexidine can be decreased when used in combination with Naproxen.
Tolmetin Tolmetin The therapeutic efficacy of Lofexidine can be decreased when used in combination with Tolmetin.
Sulindac Sulindac The therapeutic efficacy of Lofexidine can be decreased when used in combination with Sulindac.
Trazodone Trazodone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Lofexidine.
Isotretinoin Isotretinoin Isotretinoin may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Sucralfate Sucralfate Sucralfate may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Hydroxyurea Hydroxyurea The metabolism of Lofexidine can be decreased when combined with Hydroxyurea.
Floxuridine Floxuridine Floxuridine may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Phenobarbital Phenobarbital The therapeutic efficacy of Phenobarbital can be increased when used in combination with Lofexidine.
Metaxalone Metaxalone The therapeutic efficacy of Metaxalone can be increased when used in combination with Lofexidine.
Methotrexate Injection Methotrexate Injection Methotrexate may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Levorphanol Levorphanol The therapeutic efficacy of Levorphanol can be increased when used in combination with Lofexidine.
Primidone Primidone The therapeutic efficacy of Primidone can be increased when used in combination with Lofexidine.
Methsuximide Methsuximide The therapeutic efficacy of Methsuximide can be increased when used in combination with Lofexidine.
Diethylpropion Diethylpropion The therapeutic efficacy of Diethylpropion can be increased when used in combination with Lofexidine.
Chlorpromazine Chlorpromazine The therapeutic efficacy of Chlorpromazine can be increased when used in combination with Lofexidine.
Diazepam Diazepam The therapeutic efficacy of Diazepam can be increased when used in combination with Lofexidine.
Oxazepam Oxazepam The therapeutic efficacy of Oxazepam can be increased when used in combination with Lofexidine.
Flurazepam Flurazepam The therapeutic efficacy of Flurazepam can be increased when used in combination with Lofexidine.
Clorazepate Clorazepate The therapeutic efficacy of Clorazepic acid can be increased when used in combination with Lofexidine.
Lorazepam Lorazepam The therapeutic efficacy of Lorazepam can be increased when used in combination with Lofexidine.
Phenoxybenzamine Phenoxybenzamine The therapeutic efficacy of Lofexidine can be decreased when used in combination with Phenoxybenzamine.
Carmustine Carmustine The metabolism of Lofexidine can be decreased when combined with Carmustine.
Amantadine Amantadine The risk or severity of QTc prolongation can be increased when Amantadine is combined with Lofexidine.
Codeine Codeine The therapeutic efficacy of Codeine can be increased when used in combination with Lofexidine.
Meprobamate Meprobamate The therapeutic efficacy of Meprobamate can be increased when used in combination with Lofexidine.
Chlordiazepoxide Chlordiazepoxide The therapeutic efficacy of Chlordiazepoxide can be increased when used in combination with Lofexidine.
Bromocriptine Bromocriptine The therapeutic efficacy of Bromocriptine can be increased when used in combination with Lofexidine.
Metaproterenol Metaproterenol The risk or severity of hypertension can be increased when Orciprenaline is combined with Lofexidine.
Tranylcypromine Tranylcypromine The therapeutic efficacy of Tranylcypromine can be increased when used in combination with Lofexidine.
Phenelzine Phenelzine The therapeutic efficacy of Phenelzine can be increased when used in combination with Lofexidine.
Procarbazine Procarbazine The therapeutic efficacy of Procarbazine can be increased when used in combination with Lofexidine.
Ergoloid Mesylates Ergoloid Mesylates The therapeutic efficacy of Ergoloid mesylate can be increased when used in combination with Lofexidine.
Tetracycline Tetracycline Tetracycline may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Minocycline Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Lofexidine.
Prochlorperazine Prochlorperazine The therapeutic efficacy of Prochlorperazine can be increased when used in combination with Lofexidine.
Thioridazine Thioridazine The therapeutic efficacy of Thioridazine can be increased when used in combination with Lofexidine.
Trifluoperazine Trifluoperazine The therapeutic efficacy of Trifluoperazine can be increased when used in combination with Lofexidine.
Bleomycin Bleomycin Bleomycin may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Sulfadiazine Sulfadiazine Sulfadiazine may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Oxycodone Oxycodone The therapeutic efficacy of Oxycodone can be increased when used in combination with Lofexidine.
Methadone Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Lofexidine.
Oxybutynin Oxybutynin Lofexidine may increase the central nervous system depressant (CNS depressant) activities of Oxybutynin.
Benztropine Benztropine The risk or severity of QTc prolongation can be increased when Benzatropine is combined with Lofexidine.
Maprotiline Maprotiline The therapeutic efficacy of Maprotiline can be increased when used in combination with Lofexidine.
Ibuprofen Ibuprofen The therapeutic efficacy of Lofexidine can be decreased when used in combination with Ibuprofen.
Trihexyphenidyl Trihexyphenidyl Lofexidine may increase the central nervous system depressant (CNS depressant) activities of Trihexyphenidyl.
Orphenadrine Orphenadrine The therapeutic efficacy of Orphenadrine can be increased when used in combination with Lofexidine.
Perphenazine Perphenazine The therapeutic efficacy of Perphenazine can be increased when used in combination with Lofexidine.
Azathioprine Azathioprine The metabolism of Lofexidine can be decreased when combined with Azathioprine.
Fluphenazine Fluphenazine The therapeutic efficacy of Fluphenazine can be increased when used in combination with Lofexidine.
Phentermine Phentermine The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Lofexidine.
Methylphenidate Methylphenidate Methylphenidate may decrease the antihypertensive activities of Lofexidine.
Amoxapine Amoxapine The therapeutic efficacy of Amoxapine can be increased when used in combination with Lofexidine.
Sulfasalazine Sulfasalazine The therapeutic efficacy of Lofexidine can be decreased when used in combination with Sulfasalazine.
Doxorubicin Doxorubicin The metabolism of Lofexidine can be decreased when combined with Doxorubicin.
Phenazopyridine Phenazopyridine Phenazopyridine may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Carbamazepine Carbamazepine The therapeutic efficacy of Carbamazepine can be increased when used in combination with Lofexidine.
Molindone Molindone The therapeutic efficacy of Molindone can be increased when used in combination with Lofexidine.
Methyldopa Methyldopa Methyldopa may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Clonidine Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Lofexidine.
Prazosin Prazosin The risk or severity of hypotension can be increased when Prazosin is combined with Lofexidine.
Hydralazine Hydralazine Hydralazine may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Cimetidine Cimetidine The metabolism of Lofexidine can be decreased when combined with Cimetidine.
Gentamicin Injection Gentamicin Injection Gentamicin may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Warfarin Warfarin Lofexidine may decrease the excretion rate of Warfarin which could result in a higher serum level.
Clonazepam Clonazepam The therapeutic efficacy of Clonazepam can be increased when used in combination with Lofexidine.
Loperamide Loperamide The risk or severity of QTc prolongation can be increased when Loperamide is combined with Lofexidine.
Promethazine Promethazine The therapeutic efficacy of Promethazine can be increased when used in combination with Lofexidine.
Meclofenamate Meclofenamate The therapeutic efficacy of Lofexidine can be decreased when used in combination with Meclofenamic acid.
Nitrofurantoin Nitrofurantoin Nitrofurantoin may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Griseofulvin Griseofulvin The metabolism of Lofexidine can be increased when combined with Griseofulvin.
Digoxin Digoxin Lofexidine may decrease the excretion rate of Digoxin which could result in a higher serum level.
Loxapine Loxapine The therapeutic efficacy of Loxapine can be increased when used in combination with Lofexidine.
Chloroquine Chloroquine The metabolism of Lofexidine can be decreased when combined with Chloroquine.
Quinine Quinine The therapeutic efficacy of Quinine can be increased when used in combination with Lofexidine.
Ethosuximide Ethosuximide The therapeutic efficacy of Ethosuximide can be increased when used in combination with Lofexidine.
Triamterene Triamterene The metabolism of Lofexidine can be decreased when combined with Triamterene.
Chlorothiazide Chlorothiazide The therapeutic efficacy of Lofexidine can be increased when used in combination with Chlorothiazide.
Chlorthalidone Chlorthalidone Chlorthalidone may increase the excretion rate of Lofexidine which could result in a lower serum level and potentially a reduction in efficacy.
Metolazone Metolazone Metolazone may increase the excretion rate of Lofexidine which could result in a lower serum level and potentially a reduction in efficacy.
Isosorbide Isosorbide Isosorbide may increase the excretion rate of Lofexidine which could result in a lower serum level and potentially a reduction in efficacy.
Secobarbital Secobarbital The therapeutic efficacy of Secobarbital can be increased when used in combination with Lofexidine.
Desipramine Desipramine The therapeutic efficacy of Desipramine can be increased when used in combination with Lofexidine.
Amitriptyline Amitriptyline The therapeutic efficacy of Amitriptyline can be increased when used in combination with Lofexidine.
Imipramine Imipramine The therapeutic efficacy of Imipramine can be increased when used in combination with Lofexidine.
Probenecid Probenecid Probenecid may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Quinidine Quinidine The risk or severity of QTc prolongation can be increased when Lofexidine is combined with Quinidine.
Procainamide Procainamide The metabolism of Procainamide can be decreased when combined with Lofexidine.
Isoniazid Isoniazid The metabolism of Lofexidine can be decreased when combined with Isoniazid.
Pyrazinamide Pyrazinamide Pyrazinamide may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Rifampin Rifampin The metabolism of Lofexidine can be increased when combined with Rifampicin.
Disopyramide Disopyramide The risk or severity of QTc prolongation can be increased when Lofexidine is combined with Disopyramide.
Valproic Acid Valproic Acid The therapeutic efficacy of Valproic acid can be increased when used in combination with Lofexidine.
Tamoxifen Tamoxifen The metabolism of Lofexidine can be decreased when combined with Tamoxifen.
Butabarbital Butabarbital The therapeutic efficacy of Butabarbital can be increased when used in combination with Lofexidine.
Liothyronine Liothyronine Liothyronine may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Methimazole Methimazole The metabolism of Lofexidine can be decreased when combined with Methimazole.
Chlorpropamide Chlorpropamide Chlorpropamide may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Tolbutamide Tolbutamide Tolbutamide may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Tolazamide Tolazamide Tolazamide may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Dextromethorphan Dextromethorphan The therapeutic efficacy of Dextromethorphan can be increased when used in combination with Lofexidine.
Cyclobenzaprine Cyclobenzaprine The therapeutic efficacy of Cyclobenzaprine can be increased when used in combination with Lofexidine.
Niacin Niacin The metabolism of Lofexidine can be decreased when combined with Niacin.
Baclofen Baclofen The therapeutic efficacy of Baclofen can be increased when used in combination with Lofexidine.
Doxylamine Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Lofexidine.
Cyproheptadine Cyproheptadine The therapeutic efficacy of Cyproheptadine can be increased when used in combination with Lofexidine.
Clemastine Clemastine The therapeutic efficacy of Clemastine can be increased when used in combination with Lofexidine.
Chlorpheniramine Chlorpheniramine The therapeutic efficacy of Chlorpheniramine can be increased when used in combination with Lofexidine.
Brompheniramine Brompheniramine The therapeutic efficacy of Dexbrompheniramine can be increased when used in combination with Lofexidine.
Meclizine Meclizine The therapeutic efficacy of Meclizine can be increased when used in combination with Lofexidine.
Ethambutol Ethambutol Ethambutol may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Methyclothiazide Methyclothiazide The therapeutic efficacy of Lofexidine can be increased when used in combination with Methyclothiazide.
Hydrochlorothiazide Hydrochlorothiazide The therapeutic efficacy of Lofexidine can be increased when used in combination with Hydrochlorothiazide.
Dantrolene Dantrolene The therapeutic efficacy of Dantrolene can be increased when used in combination with Lofexidine.
Chlorzoxazone Chlorzoxazone The therapeutic efficacy of Chlorzoxazone can be increased when used in combination with Lofexidine.
Carisoprodol Carisoprodol The therapeutic efficacy of Carisoprodol can be increased when used in combination with Lofexidine.
Methocarbamol Methocarbamol The therapeutic efficacy of Methocarbamol can be increased when used in combination with Lofexidine.
Pyridoxine Pyridoxine Pyridoxine may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Folic Acid Folic Acid Folic acid may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Disulfiram Disulfiram The risk or severity of QTc prolongation can be increased when Disulfiram is combined with Lofexidine.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The therapeutic efficacy of Lofexidine can be decreased when used in combination with Propranolol.
Minoxidil Minoxidil Minoxidil may decrease the antihypertensive activities of Lofexidine.
Pseudoephedrine Pseudoephedrine The risk or severity of serotonin syndrome can be increased when Pseudoephedrine is combined with Lofexidine.
Nortriptyline Nortriptyline The therapeutic efficacy of Nortriptyline can be increased when used in combination with Lofexidine.
Spironolactone Spironolactone The therapeutic efficacy of Lofexidine can be decreased when used in combination with Spironolactone.
Amphotericin B Injection Amphotericin B Injection Amphotericin B may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Phytonadione Phytonadione Phylloquinone may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Amikacin Injection Amikacin Injection Amikacin may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Nadolol Nadolol The therapeutic efficacy of Lofexidine can be decreased when used in combination with Nadolol.
Butorphanol Injection Butorphanol Injection The therapeutic efficacy of Butorphanol can be increased when used in combination with Lofexidine.
Nalbuphine Injection Nalbuphine Injection The therapeutic efficacy of Nalbuphine can be increased when used in combination with Lofexidine.
Allopurinol Allopurinol Allopurinol may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Oxytocin Injection Oxytocin Injection The risk or severity of QTc prolongation can be increased when Oxytocin is combined with Lofexidine.
Trimethobenzamide Trimethobenzamide The therapeutic efficacy of Trimethobenzamide can be increased when used in combination with Lofexidine.
Flavoxate Flavoxate Flavoxate may increase the central nervous system depressant (CNS depressant) activities of Lofexidine.
Papaverine Papaverine The risk or severity of QTc prolongation can be increased when Papaverine is combined with Lofexidine.
Fluorouracil Injection Fluorouracil Injection The metabolism of Lofexidine can be decreased when combined with Fluorouracil.
Colchicine Colchicine Colchicine may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Cefaclor Cefaclor Cefaclor may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Cefadroxil Cefadroxil Cefadroxil may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Cefazolin Injection Cefazolin Injection Cefazolin may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Cephalexin Cephalexin Cephalexin may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Cefoxitin Injection Cefoxitin Injection Cefoxitin may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Dacarbazine Dacarbazine The metabolism of Lofexidine can be decreased when combined with Dacarbazine.
Acetazolamide Acetazolamide The therapeutic efficacy of Acetazolamide can be increased when used in combination with Lofexidine.
Cefotaxime Injection Cefotaxime Injection Cefotaxime may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Calcitonin Salmon Injection Calcitonin Salmon Injection Salmon calcitonin may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Ketoconazole Ketoconazole The metabolism of Lofexidine can be decreased when combined with Ketoconazole.
Pyrantel Pyrantel The therapeutic efficacy of Pyrantel can be increased when used in combination with Lofexidine.
Captopril Captopril Captopril may decrease the antihypertensive activities of Lofexidine.
Dipyridamole Dipyridamole Dipyridamole may increase the antihypertensive activities of Lofexidine.
Isoxsuprine Isoxsuprine Isoxsuprine may decrease the antihypertensive activities of Lofexidine.
Vinblastine Vinblastine The metabolism of Lofexidine can be decreased when combined with Vinblastine.
Ethacrynic Acid Ethacrynic Acid Etacrynic acid may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Colistimethate Injection Colistimethate Injection Colistimethate may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Metoprolol Metoprolol The metabolism of Lofexidine can be decreased when combined with Metoprolol.
Hydroxyzine Hydroxyzine The risk or severity of QTc prolongation can be increased when Lofexidine is combined with Hydroxyzine.
Thiothixene Thiothixene The therapeutic efficacy of Thiothixene can be increased when used in combination with Lofexidine.
Aspirin Aspirin Acetylsalicylic acid may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Salsalate Salsalate The therapeutic efficacy of Lofexidine can be decreased when used in combination with Salsalate.
Alprazolam Alprazolam The therapeutic efficacy of Alprazolam can be increased when used in combination with Lofexidine.
Temazepam Temazepam The therapeutic efficacy of Temazepam can be increased when used in combination with Lofexidine.
Triazolam Triazolam The therapeutic efficacy of Triazolam can be increased when used in combination with Lofexidine.
Dicyclomine Dicyclomine Dicyclomine may increase the central nervous system depressant (CNS depressant) activities of Lofexidine.
Hyoscyamine Hyoscyamine The risk or severity of QTc prolongation can be increased when Hyoscyamine is combined with Lofexidine.
Propantheline Propantheline Propantheline may increase the central nervous system depressant (CNS depressant) activities of Lofexidine.
Trimethoprim Trimethoprim Trimethoprim may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Diltiazem Diltiazem The risk or severity of QTc prolongation can be increased when Diltiazem is combined with Lofexidine.
Nifedipine Nifedipine The metabolism of Lofexidine can be decreased when combined with Nifedipine.
Timolol Timolol The therapeutic efficacy of Lofexidine can be decreased when used in combination with Timolol.
Verapamil Verapamil The therapeutic efficacy of Lofexidine can be decreased when used in combination with Verapamil.
Atenolol Atenolol The therapeutic efficacy of Lofexidine can be decreased when used in combination with Atenolol.
Pindolol Pindolol The therapeutic efficacy of Pindolol can be increased when used in combination with Lofexidine.
Cisplatin Injection Cisplatin Injection Lofexidine may decrease the excretion rate of Cisplatin which could result in a higher serum level.
Diflunisal Diflunisal The therapeutic efficacy of Lofexidine can be decreased when used in combination with Diflunisal.
Piroxicam Piroxicam The therapeutic efficacy of Lofexidine can be decreased when used in combination with Piroxicam.
Bumetanide Bumetanide Bumetanide may increase the excretion rate of Lofexidine which could result in a lower serum level and potentially a reduction in efficacy.
Streptozocin Streptozocin The metabolism of Lofexidine can be increased when combined with Streptozocin.
Etoposide Etoposide The metabolism of Lofexidine can be decreased when combined with Etoposide.
Glipizide Glipizide Glipizide may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Indapamide Indapamide The therapeutic efficacy of Lofexidine can be increased when used in combination with Indapamide.
Amoxicillin Amoxicillin Amoxicillin may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Nafcillin Injection Nafcillin Injection The metabolism of Lofexidine can be increased when combined with Nafcillin.
Oxacillin Injection Oxacillin Injection Oxacillin may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Pentoxifylline Pentoxifylline Pentoxifylline may increase the hypotensive activities of Lofexidine.
Pentamidine Injection Pentamidine Injection Pentamidine may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Ceftriaxone Injection Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Labetalol Labetalol The therapeutic efficacy of Lofexidine can be decreased when used in combination with Labetalol.
Auranofin Auranofin Auranofin may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Leuprolide Injection Leuprolide Injection The risk or severity of QTc prolongation can be increased when Leuprolide is combined with Lofexidine.
Gemfibrozil Gemfibrozil The metabolism of Lofexidine can be decreased when combined with Gemfibrozil.
Guanabenz Guanabenz The metabolism of Lofexidine can be decreased when combined with Guanabenz.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Ceftazidime Injection Ceftazidime Injection Ceftazidime may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Ketoprofen Ketoprofen The therapeutic efficacy of Lofexidine can be decreased when used in combination with Ketoprofen.
Cefotetan Injection Cefotetan Injection Cefotetan may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Pimozide Pimozide The therapeutic efficacy of Pimozide can be increased when used in combination with Lofexidine.
Enalapril Enalapril Enalapril may decrease the antihypertensive activities of Lofexidine.
Flurbiprofen Flurbiprofen The therapeutic efficacy of Lofexidine can be decreased when used in combination with Flurbiprofen.
Amiodarone Amiodarone The risk or severity of QTc prolongation can be increased when Amiodarone is combined with Lofexidine.
Aztreonam Injection Aztreonam Injection Aztreonam may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Buspirone Buspirone The risk or severity of serotonin syndrome can be increased when Buspirone is combined with Lofexidine.
Lovastatin Lovastatin The metabolism of Lofexidine can be decreased when combined with Lovastatin.
Ciprofloxacin Ciprofloxacin The metabolism of Lofexidine can be decreased when combined with Ciprofloxacin.
Mesalamine Mesalamine The therapeutic efficacy of Lofexidine can be decreased when used in combination with Mesalazine.
Diclofenac Diclofenac The therapeutic efficacy of Lofexidine can be decreased when used in combination with Diclofenac.
Fluoxetine Fluoxetine The therapeutic efficacy of Fluoxetine can be increased when used in combination with Lofexidine.
Nimodipine Nimodipine The risk or severity of QTc prolongation can be increased when Nimodipine is combined with Lofexidine.
Interferon Alfa-2b Injection Interferon Alfa-2b Injection The metabolism of Lofexidine can be decreased when combined with Interferon alfa-2b.
Clozapine Clozapine The therapeutic efficacy of Clozapine can be increased when used in combination with Lofexidine.
Estazolam Estazolam The therapeutic efficacy of Estazolam can be increased when used in combination with Lofexidine.
Idarubicin Idarubicin The metabolism of Lofexidine can be decreased when combined with Idarubicin.
Ofloxacin Ofloxacin The metabolism of Lofexidine can be decreased when combined with Ofloxacin.
Didanosine Didanosine Didanosine may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Pentostatin Injection Pentostatin Injection Pentostatin may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Clarithromycin Clarithromycin The risk or severity of QTc prolongation can be increased when Clarithromycin is combined with Lofexidine.
Benazepril Benazepril Benazepril may decrease the antihypertensive activities of Lofexidine.
Etodolac Etodolac The therapeutic efficacy of Lofexidine can be decreased when used in combination with Etodolac.
Felodipine Felodipine The risk or severity of QTc prolongation can be increased when Felodipine is combined with Lofexidine.
Fosinopril Fosinopril Fosinopril may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Nabumetone Nabumetone The therapeutic efficacy of Lofexidine can be decreased when used in combination with Nabumetone.
Quinapril Quinapril Quinapril may decrease the antihypertensive activities of Lofexidine.
Ramipril Ramipril Ramipril may decrease the antihypertensive activities of Lofexidine.
Simvastatin Simvastatin The metabolism of Lofexidine can be decreased when combined with Simvastatin.
Amlodipine Amlodipine Amlodipine may decrease the antihypertensive activities of Lofexidine.
Itraconazole Itraconazole The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Lofexidine.
Lisinopril Lisinopril Lisinopril may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Oxaprozin Oxaprozin The therapeutic efficacy of Lofexidine can be decreased when used in combination with Oxaprozin.
Sotalol Sotalol The metabolism of Sotalol can be decreased when combined with Lofexidine.
Bisoprolol Bisoprolol The therapeutic efficacy of Lofexidine can be decreased when used in combination with Bisoprolol.
Zolpidem Zolpidem The therapeutic efficacy of Zolpidem can be increased when used in combination with Lofexidine.
Doxazosin Doxazosin The therapeutic efficacy of Lofexidine can be decreased when used in combination with Doxazosin.
Terazosin Terazosin The therapeutic efficacy of Lofexidine can be decreased when used in combination with Terazosin.
Isradipine Isradipine The risk or severity of QTc prolongation can be increased when Isradipine is combined with Lofexidine.
Omeprazole Omeprazole The metabolism of Lofexidine can be increased when combined with Omeprazole.
Cisapride Cisapride The therapeutic efficacy of Cisapride can be increased when used in combination with Lofexidine.
Gabapentin Gabapentin The therapeutic efficacy of Gabapentin can be increased when used in combination with Lofexidine.
Fluvastatin Fluvastatin The metabolism of Lofexidine can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine The therapeutic efficacy of Venlafaxine can be increased when used in combination with Lofexidine.
Fluvoxamine Fluvoxamine The therapeutic efficacy of Fluvoxamine can be increased when used in combination with Lofexidine.
Nefazodone Nefazodone The therapeutic efficacy of Nefazodone can be increased when used in combination with Lofexidine.
Lamotrigine Lamotrigine The therapeutic efficacy of Lamotrigine can be increased when used in combination with Lofexidine.
Losartan Losartan The risk or severity of QTc prolongation can be increased when Losartan is combined with Lofexidine.
Valacyclovir Valacyclovir Valaciclovir may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Tramadol Tramadol The risk or severity of serotonin syndrome can be increased when Lofexidine is combined with Tramadol.
Vinorelbine Injection Vinorelbine Injection The metabolism of Lofexidine can be decreased when combined with Vinorelbine.
Carboplatin Injection Carboplatin Injection Carboplatin may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Moexipril Moexipril The risk or severity of QTc prolongation can be increased when Moexipril is combined with Lofexidine.
Lansoprazole Lansoprazole The metabolism of Lofexidine can be decreased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection Ifosfamide may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Nicardipine Nicardipine The metabolism of Lofexidine can be decreased when combined with Nicardipine.
Bupropion Bupropion The therapeutic efficacy of Bupropion can be increased when used in combination with Lofexidine.
Ticlopidine Ticlopidine The metabolism of Lofexidine can be decreased when combined with Ticlopidine.
Saquinavir Saquinavir The risk or severity of QTc prolongation can be increased when Saquinavir is combined with Lofexidine.
Metformin Metformin The excretion of Metformin can be decreased when combined with Lofexidine.
Nisoldipine Nisoldipine Nisoldipine may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Lamivudine Lamivudine Lamivudine may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Riluzole Riluzole The therapeutic efficacy of Riluzole can be increased when used in combination with Lofexidine.
Amifostine Injection Amifostine Injection Lofexidine may increase the hypotensive activities of Amifostine.
Acarbose Acarbose Acarbose may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Gemcitabine Injection Gemcitabine Injection Gemcitabine may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Ritonavir Ritonavir The metabolism of Lofexidine can be decreased when combined with Ritonavir.
Cidofovir Injection Cidofovir Injection Cidofovir may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Meropenem Injection Meropenem Injection Meropenem may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Clomipramine Clomipramine The therapeutic efficacy of Clomipramine can be increased when used in combination with Lofexidine.
Zafirlukast Zafirlukast The metabolism of Lofexidine can be decreased when combined with Zafirlukast.
Fosfomycin Fosfomycin Fosfomycin may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Mirtazapine Mirtazapine Lofexidine may increase the serotonergic activities of Mirtazapine.
Trandolapril Trandolapril Trandolapril may decrease the antihypertensive activities of Lofexidine.
Topiramate Topiramate The therapeutic efficacy of Topiramate can be increased when used in combination with Lofexidine.
Zileuton Zileuton The metabolism of Lofexidine can be decreased when combined with Zileuton.
Valsartan Valsartan Valsartan may decrease the antihypertensive activities of Lofexidine.
Insulin Lispro Injection Insulin Lispro Injection The metabolism of Lofexidine can be increased when combined with Insulin lispro.
Pramipexole Pramipexole Lofexidine may increase the sedative activities of Pramipexole.
Donepezil Donepezil The therapeutic efficacy of Donepezil can be increased when used in combination with Lofexidine.
Nelfinavir Nelfinavir The metabolism of Lofexidine can be decreased when combined with Nelfinavir.
Azithromycin Azithromycin The risk or severity of QTc prolongation can be increased when Azithromycin is combined with Lofexidine.
Carvedilol Carvedilol The therapeutic efficacy of Lofexidine can be decreased when used in combination with Carvedilol.
Nilutamide Nilutamide Nilutamide may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Flutamide Flutamide The metabolism of Lofexidine can be decreased when combined with Flutamide.
Selegiline Selegiline The therapeutic efficacy of Selegiline can be increased when used in combination with Lofexidine.
Bicalutamide Bicalutamide The metabolism of Lofexidine can be decreased when combined with Bicalutamide.
Sertraline Sertraline The therapeutic efficacy of Sertraline can be increased when used in combination with Lofexidine.
Propafenone Propafenone The therapeutic efficacy of Lofexidine can be decreased when used in combination with Propafenone.
Irbesartan Irbesartan Irbesartan may decrease the antihypertensive activities of Lofexidine.
Tamsulosin Tamsulosin The therapeutic efficacy of Lofexidine can be decreased when used in combination with Tamsulosin.
Ropinirole Ropinirole The therapeutic efficacy of Ropinirole can be increased when used in combination with Lofexidine.
Finasteride Finasteride The risk or severity of hypertension can be increased when Finasteride is combined with Lofexidine.
Quetiapine Quetiapine The therapeutic efficacy of Quetiapine can be increased when used in combination with Lofexidine.
Cefepime Injection Cefepime Injection Cefepime may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Cefprozil Cefprozil Cefprozil may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Cefpodoxime Cefpodoxime Cefpodoxime may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Cetirizine Cetirizine The therapeutic efficacy of Cetirizine can be increased when used in combination with Lofexidine.
Paroxetine Paroxetine The therapeutic efficacy of Paroxetine can be increased when used in combination with Lofexidine.
Tolcapone Tolcapone The therapeutic efficacy of Tolcapone can be increased when used in combination with Lofexidine.
Citalopram Citalopram The therapeutic efficacy of Citalopram can be increased when used in combination with Lofexidine.
Capecitabine Capecitabine Capecitabine may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Efavirenz Efavirenz The therapeutic efficacy of Efavirenz can be increased when used in combination with Lofexidine.
Abacavir Abacavir Abacavir may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Sildenafil Sildenafil Sildenafil may increase the antihypertensive activities of Lofexidine.
Celecoxib Celecoxib The metabolism of Lofexidine can be decreased when combined with Celecoxib.
Rosiglitazone Rosiglitazone The metabolism of Lofexidine can be decreased when combined with Rosiglitazone.
Tolterodine Tolterodine The risk or severity of QTc prolongation can be increased when Tolterodine is combined with Lofexidine.
Thalidomide Thalidomide Lofexidine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Oseltamivir Oseltamivir Oseltamivir may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Balsalazide Balsalazide The therapeutic efficacy of Lofexidine can be decreased when used in combination with Balsalazide.
Nateglinide Nateglinide Nateglinide may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Galantamine Galantamine The risk or severity of QTc prolongation can be increased when Galantamine is combined with Lofexidine.
Levetiracetam Levetiracetam The therapeutic efficacy of Levetiracetam can be increased when used in combination with Lofexidine.
Rabeprazole Rabeprazole The metabolism of Lofexidine can be increased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Lofexidine can be decreased when combined with Terbinafine.

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