Medication interaction hub

What Supplements Interact with Lofexidine Hydrochloride?

Lofexidine Hydrochloride brand name: Lucemyra. Every interaction below applies to the brands too.

139 Interactions 3 Major 95 Moderate 41 Minor
Curated & coded by · Clinical Pharmacist · Updated September 25, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Lofexidine Hydrochloride? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Lofexidine Hydrochloride against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Grapefruit is the supplement risk I would flag first for anyone taking lofexidine (Lucemyra) for opioid withdrawal. It blocks the enzyme (CYP3A4) that clears lofexidine, and higher levels can deepen the low blood pressure and drowsiness this drug already causes. That makes it one of three major entries among 139 interacting ingredients, a list that warrants real vigilance. The other majors are St. John's wort, which speeds the drug's breakdown so withdrawal symptoms can break through, and activated charcoal, which can keep a dose from being absorbed at all.

The 95 moderate and 41 minor entries mostly echo that mechanism, since 121 of the 139 ingredients nudge the CYP3A4 pathway up or down, worth a pharmacist's check on a drug this sensitive to blood pressure swings. Another 17 can change how oral doses are absorbed, so take those well apart from your lofexidine and read their full entries below.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 95 Minor 41 No known interaction 1,313

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Lofexidine Hydrochloride: Top Interactions at a Glance

The Lofexidine Hydrochloride supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 139 interacting ingredients — plus 1,313 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Lofexidine Hydrochloride Combinations Today

The Lofexidine Hydrochloride + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible African Wild Potato + Lofexidine Hydrochloridei

In vitro evidence shows that African wild potato extract can inhibit cytochrome P450 3A4 (CYP3A4) enzyme activity by up to 86%.

Read the full interaction Major Likelihood Probable Activated Charcoal + Lofexidine Hydrochloridei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Moderate Likelihood Possible Acacia Rigidula + Lofexidine Hydrochloridei

Theoretically, Acacia rigidula products that are adulterated with beta-methylphenylethylamine (BMPEA) might increase the levels of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible Astaxanthin + Lofexidine Hydrochloridei

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Likely Grapefruit + Lofexidine Hydrochloridei

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible American Elder + Lofexidine Hydrochloridei

Theoretically, taking American elder might increase levels of CYP3A4 substrates.

Read the full interaction
The complete list

Every Supplement Checked Against Lofexidine Hydrochloride

All 1,452 ingredients in our database, ranked by severity — 139 with a Lofexidine Hydrochloride interaction on file and 1,313 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Lofexidine Hydrochloride?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take African Wild Potato with Lofexidine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence shows that African wild potato extract can inhibit cytochrome P450 3A4 (CYP3A4) enzyme activity by up to 86%.

Full African Wild Potato + Lofexidine Hydrochloride answer

Can you take Activated Charcoal with Lofexidine Hydrochloride?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Lofexidine Hydrochloride answer

Can you take Acacia Rigidula with Lofexidine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Acacia rigidula products that are adulterated with beta-methylphenylethylamine (BMPEA) might increase the levels of CYP3A4 su...

Full Acacia Rigidula + Lofexidine Hydrochloride answer

Can you take Astaxanthin with Lofexidine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.

Full Astaxanthin + Lofexidine Hydrochloride answer

Can you take Grapefruit with Lofexidine Hydrochloride?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Full Grapefruit + Lofexidine Hydrochloride answer

Can you take Yerba Mate with Lofexidine Hydrochloride?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, yerba mate might increase the levels and clinical effects of CYP3A4 substrates.

Full Yerba Mate + Lofexidine Hydrochloride answer

Can you take Yohimbe with Lofexidine Hydrochloride?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, yohimbe might decrease the levels and clinical effects of CYP3A4 substrates.

Full Yohimbe + Lofexidine Hydrochloride answer

Can you take Delta-9-tetrahydrocannabinol (thc) with Lofexidine Hydrochloride?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, THC may increase the levels and clinical effects of CYP3A4 substrates.

Full Delta-9-tetrahydrocannabinol (thc) + Lofexidine Hydrochloride answer

Can you take Eleuthero with Lofexidine Hydrochloride?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.

Full Eleuthero + Lofexidine Hydrochloride answer

Can you take Green Tea with Lofexidine Hydrochloride?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Green tea is unlikely to produce clinically significant changes in the levels and clinical effects of CYP3A4 substrates.

Full Green Tea + Lofexidine Hydrochloride answer

Can you take Gymnema with Lofexidine Hydrochloride?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.

Full Gymnema + Lofexidine Hydrochloride answer

Can you take Humann Superbeets Heart Chews with Lofexidine Hydrochloride?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Full Humann Superbeets Heart Chews + Lofexidine Hydrochloride answer

Can you take Jequirity with Lofexidine Hydrochloride?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. In vitro research shows that jequirity extract inhibits CYP3A4 enzymes.

Full Jequirity + Lofexidine Hydrochloride answer

Can you take Kava with Lofexidine Hydrochloride?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. It is unclear if kava inhibits CYP3AA; research is conflicting.

Full Kava + Lofexidine Hydrochloride answer

Can you take Milk Thistle with Lofexidine Hydrochloride?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. It is unclear if milk thistle inhibits CYP3A4; research is conflicting.

Full Milk Thistle + Lofexidine Hydrochloride answer

Can you take Mommy's Bliss Gripe Water with Lofexidine Hydrochloride?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Mommy's Bliss Gripe Water contains fennel seed.

Full Mommy's Bliss Gripe Water + Lofexidine Hydrochloride answer

Can you take Polypodium Leucotomos with Lofexidine Hydrochloride?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Polypodium leucotomos might increase levels of drugs metabolized by CYP3A4.

Full Polypodium Leucotomos + Lofexidine Hydrochloride answer

Can you take Pomegranate with Lofexidine Hydrochloride?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to...

Full Pomegranate + Lofexidine Hydrochloride answer

Can you take Red Clover with Lofexidine Hydrochloride?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, red clover might increase levels of drugs metabolized by CYP3A4; however, a small clinical study found no effect.

Full Red Clover + Lofexidine Hydrochloride answer

Can you take Tangerine with Lofexidine Hydrochloride?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).

Full Tangerine + Lofexidine Hydrochloride answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Lofexidine Hydrochloride is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Lofexidine Hydrochloride, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Lofexidine Hydrochloride sits in 3 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Lofexidine Hydrochloride through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Lofexidine Hydrochloride through this category.

Alpha-Adrenergic Agonists 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Lofexidine Hydrochloride through this category.

About Lofexidine Hydrochloride

Lofexidine is an oral medication used to ease opioid withdrawal symptoms in adults who are stopping opioids abruptly.

Generic name: Lofexidine Hydrochloride  ·  Brand name: Lucemyra.

See the full Lofexidine drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Lofexidine Hydrochloride

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Lofexidine Hydrochloride.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

Or scan the bottle

Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

Open the label scanner

Prefer typing? The interaction checker looks up products by name too.

Pharmacist Counseling Corner

Lofexidine Hydrochloride & Supplements: Common Questions

What supplements interact with Lofexidine Hydrochloride?
In our interaction database, 139 supplement and herbal ingredients have an interaction with Lofexidine Hydrochloride on file — 3 rated major, 95 moderate, and 41 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Grapefruit, Activated Charcoal, St. John's Wort.
Which Lofexidine Hydrochloride supplement interactions are the most serious?
Focus on the major group: Grapefruit, Activated Charcoal and St. John's Wort. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Lofexidine Hydrochloride?
That depends entirely on which supplement. The honest answer for Lofexidine Hydrochloride is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Lucemyra have the same supplement interactions as Lofexidine Hydrochloride?
Yes — Lucemyra all contain Lofexidine Hydrochloride, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Lofexidine Hydrochloride and my other medications?
This page covers Lofexidine Hydrochloride against supplements and herbal ingredients. Checking Lofexidine Hydrochloride against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Lofexidine drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

More Free Pharmacist Tools

Supplement interaction checker Check any supplement or product against your medications Supplement label scanner Photograph a Supplement Facts panel; we check every ingredient Browse medications A–Z Every drug we’ve checked against herbs & supplements Ingredient directory Every vitamin, herb & mineral we track, with interaction data Product directory Look up any bottle by name, brand, or barcode Ask a pharmacist Free, personal answer from our licensed team
Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 25, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.