Drug & supplement interaction

Cannabichromene (cbc) + Lofexidine Hydrochloride

Lofexidine Hydrochloride brand name: Lucemyra.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Cannabichromene (cbc) and Lofexidine Hydrochloride in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Cannabichromene (cbc) and Lofexidine Hydrochloride

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Lofexidine Hydrochloride and Cannabichromene (cbc) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Cannabichromene (cbc) safety at a glance

Cannabichromene (c... overall Not established Human safety data are very limited, so its long-term safety is not established.
Pregnancy Avoid Not enough safety data; cannabinoids are best avoided during pregnancy.
Breastfeeding Avoid Cannabinoids can pass into breast milk, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Lofexidine Hydrochloride and Cannabichromene (cbc)? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Lofexidine Hydrochloride

Interactions in our licensed database are recorded against drug classes, not just single drug names. Lofexidine Hydrochloride is filed under 3 classifications — alpha-adrenergic agonists, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Cannabichromene (cbc) has documented interactions with 1 drug class — the most serious being cns depressants (moderate) — and none of Lofexidine Hydrochloride’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Cannabichromene (cbc) Does Interact With Other Medications

Cannabichromene (cbc) has 248 moderate known drug interactions in our database — Lofexidine Hydrochloride isn’t one of them. If you take anything else, check it against the full list below.

Moderate 248 No known interaction 2,582 (incl. Lofexidine Hydrochloride)
Taking anything else?

Check Another of Your Medications Against Cannabichromene (cbc)

Covers the 2,830 medications we’ve checked against Cannabichromene (cbc). Pick one to open its full report.

What to actually watch for

What Lofexidine Hydrochloride’s Own FDA Label Lists

This is not an interaction — none of it involves Cannabichromene (cbc). These are the most notable effects listed in the ADVERSE REACTIONS section of Lofexidine Hydrochloride’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 3 of them are worth acting on rather than waiting out — marked below.

  • A slow heartbeat Worth acting on
  • Fainting Worth acting on
  • An irregular heartbeat Worth acting on
  • Low blood pressure mentioned in 10.6% of FDA reports for Lofexidine Hydrochloride
  • Dry mouth mentioned in 6.8% of FDA reports for Lofexidine Hydrochloride
  • Drowsiness mentioned in 9.3% of FDA reports for Lofexidine Hydrochloride
  • Dizziness mentioned in 14.9% of FDA reports for Lofexidine Hydrochloride
  • Trouble sleeping

From the ADVERSE REACTIONS section of the FDA label for Lofexidine Hydrochloride. Read the label on DailyMed › Where a percentage is shown, it is the share of 161 voluntary FDA FAERS reports for Lofexidine Hydrochloride that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Cannabichromene (cbc)’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Cannabichromene (cbc) side to compare — that is a limit of the record, not a statement that Cannabichromene (cbc) has no side effects.

Everything else you take

See Every Supplement That Interacts With Lofexidine Hydrochloride

This page covers Cannabichromene (cbc) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Lofexidine Hydrochloride page lists 139 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 95 moderate · 41 minor.

From our pharmacist’s overview on the Lofexidine Hydrochloride page

“Grapefruit is the supplement risk I would flag first for anyone taking lofexidine (Lucemyra) for opioid withdrawal. It blocks the enzyme (CYP3A4) that clears lofexidine, and higher levels can deepen the low blood pressure and drowsiness this drug already causes.”

Reviewed by 2 · Jul 18, 2026

Open the Lofexidine Hydrochloride interaction page

How much people look this up

Where Cannabichromene (cbc) and Lofexidine Hydrochloride Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cannabichromene (cbc)
Steady interest

#1,151 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Lofexidine Hydrochloride
Steady interest

#2,730 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Cannabichromene (cbc) reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Cannabichromene (cbc) and Lofexidine Hydrochloride records this page draws on were last updated June 20, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Cannabichromene (cbc)

What is Cannabichromene (cbc)?

Cannabichromene (cbc)
  • Pain relief
  • Inflammation
  • Mood and anxiety
  • Skin and acne concerns
  • Brain and nerve health

Cannabichromene (CBC) is a non-intoxicating cannabinoid found in the cannabis plant that is being studied for possible pain, anti-inflammatory, and nervous-system effects. Almost all current evidence comes from laboratory and animal research, so we do not yet know how well it works or how safe it is in people. Talk with your pharmacist or doctor before using any CBC product, and avoid it during pregnancy and breastfeeding.

Cannabaceae · Flowers and resin of the cannabis plant (where the cannabinoid is concentrated) · Oils and tinctures, capsules, edibles, full-spectrum hemp extracts, vape products

An interaction check asks whether these two react with each other — it does not ask whether Cannabichromene (cbc) is a good idea for someone in your situation. Here is what our Cannabichromene (cbc) record says about it on its own.

Cannabichromene (cbc): dosing

There is no established or standardized dose for CBC. Because human research is so limited, experts cannot recommend a specific amount that is known to be safe or effective.If you choose to try a CBC product, follow the directions on the product label and consider starting low. Look for products that have been tested by an independent lab and provide a certificate of analysis.

From our Cannabichromene (cbc) monograph — the full record covers uses, side effects and every documented interaction.

Read the full Cannabichromene (cbc) monograph & all interactions
Medication

About Lofexidine

What Is Lofexidine Used For?

Brand name: Lucemyra

Lofexidine tablets — sold under the brand name Lucemyra, as well as under the generic names lofexidine and lofexidine hydrochloride — are approved for adults to help manage the physical symptoms of opioid withdrawal when opioids are stopped suddenly.

It is not a treatment for opioid use disorder on its own. It is meant to be used as part of a broader, comprehensive treatment program.

Most-Reported Side Effects for Lofexidine Hydrochloride

From FAERS, the FDA’s public side-effect reporting system (161 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dizziness 24 reports
Hypotension 17 reports
Somnolence 15 reports
Dyspnea 14 reports
Diarrhea 12 reports
See full Lofexidine drug information
Keep checking

Other Drugs & Cannabichromene (cbc)

Browse every other medication we’ve checked against Cannabichromene (cbc) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
248Moderate
0Minor
2,581No known interaction
248 Moderate 2,581 No interaction
Moderate

248 interactions

Showing 60 of 248 moderate interactions — see all 248 on the Cannabichromene (cbc) page.

No interaction 2,581 drugs checked — show the list

We also checked Cannabichromene (cbc) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,581 medications checked with no known interaction — see the full Cannabichromene (cbc) list.

See the full Cannabichromene (cbc) interactions page
See every supplement checked against Lofexidine Hydrochloride, ranked by severity
Evidence & sources

Cannabichromene (cbc) References

The 1 references that drive our Cannabichromene (cbc) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Hatoum NS, Davis WM, Waters IW, Elsohly MA, Turner CE. Synergism of cannabichromene and CNS depressants in mice. Gen Pharmacol. 1981;12(5):351-6. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Cannabichromene (cbc) and Lofexidine Hydrochloride Together: Common Questions

Is it safe to take Cannabichromene (cbc) with Lofexidine Hydrochloride?
We do not list a known interaction between Cannabichromene (cbc) and Lofexidine Hydrochloride. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Cannabichromene (cbc) and Lofexidine Hydrochloride combination checked?
Interactions in our licensed database are recorded against drug classes. Lofexidine Hydrochloride is filed under 3 classifications, and Cannabichromene (cbc) has documented interactions with 1 drug class — none of Lofexidine Hydrochloride's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Cannabichromene (cbc) interact with any other medications?
Yes. Cannabichromene (cbc) has 248 documented drug interactions in our database — Lofexidine Hydrochloride is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Lofexidine Hydrochloride interact with any supplements?
Yes. Lofexidine Hydrochloride has documented interactions with 139 supplements in our database — Cannabichromene (cbc) is not one of them. The Lofexidine Hydrochloride interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Cannabichromene (cbc) monograph Uses, safety profile, and every drug interaction in one place Lofexidine drug information The full plain-English guide to this medication Lofexidine Hydrochloride supplement interactions Every supplement checked against Lofexidine Hydrochloride, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Lofexidine Hydrochloride and Cannabichromene (cbc)?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.