Drug & supplement interaction

Brickellia + Lofexidine Hydrochloride

Lofexidine Hydrochloride brand name: Lucemyra.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Brickellia and Lofexidine Hydrochloride in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Brickellia and Lofexidine Hydrochloride

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Lofexidine Hydrochloride and Brickellia in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Brickellia safety at a glance

Brickellia overall Not established Human safety data are very limited, so use cautiously and under professional guidance.
Pregnancy Avoid Not enough safety information exists, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so it is best avoided.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Lofexidine Hydrochloride and Brickellia? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Lofexidine Hydrochloride

Interactions in our licensed database are recorded against drug classes, not just single drug names. Lofexidine Hydrochloride is filed under 3 classifications — alpha-adrenergic agonists, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Brickellia has documented interactions with 1 drug class — the most serious being antidiabetes drugs (moderate) — and none of Lofexidine Hydrochloride’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Brickellia Does Interact With Other Medications

Brickellia has 86 moderate known drug interactions in our database — Lofexidine Hydrochloride isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Lofexidine Hydrochloride)
Taking anything else?

Check Another of Your Medications Against Brickellia

Covers the 2,830 medications we’ve checked against Brickellia. Pick one to open its full report.

What to actually watch for

What Lofexidine Hydrochloride’s Own FDA Label Lists

This is not an interaction — none of it involves Brickellia. These are the most notable effects listed in the ADVERSE REACTIONS section of Lofexidine Hydrochloride’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 3 of them are worth acting on rather than waiting out — marked below.

  • A slow heartbeat Worth acting on
  • Fainting Worth acting on
  • An irregular heartbeat Worth acting on
  • Low blood pressure mentioned in 10.6% of FDA reports for Lofexidine Hydrochloride
  • Dry mouth mentioned in 6.8% of FDA reports for Lofexidine Hydrochloride
  • Drowsiness mentioned in 9.3% of FDA reports for Lofexidine Hydrochloride
  • Dizziness mentioned in 14.9% of FDA reports for Lofexidine Hydrochloride
  • Trouble sleeping

From the ADVERSE REACTIONS section of the FDA label for Lofexidine Hydrochloride. Read the label on DailyMed › Where a percentage is shown, it is the share of 161 voluntary FDA FAERS reports for Lofexidine Hydrochloride that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Brickellia’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Brickellia side to compare — that is a limit of the record, not a statement that Brickellia has no side effects.

Everything else you take

See Every Supplement That Interacts With Lofexidine Hydrochloride

This page covers Brickellia only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Lofexidine Hydrochloride page lists 139 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 95 moderate · 41 minor.

From our pharmacist’s overview on the Lofexidine Hydrochloride page

“Grapefruit is the supplement risk I would flag first for anyone taking lofexidine (Lucemyra) for opioid withdrawal. It blocks the enzyme (CYP3A4) that clears lofexidine, and higher levels can deepen the low blood pressure and drowsiness this drug already causes.”

Reviewed by 2 · Jul 18, 2026

Open the Lofexidine Hydrochloride interaction page

How much people look this up

Where Brickellia and Lofexidine Hydrochloride Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Brickellia
Steady interest

#752 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Lofexidine Hydrochloride
Steady interest

#2,420 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Brickellia reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Brickellia and Lofexidine Hydrochloride records this page draws on were last updated June 20, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Brickellia

What is Brickellia?

  • Blood sugar support (diabetes)
  • Digestive complaints
  • Gallbladder and bile flow
  • Colds and fever

Brickellia, often sold under names like 'prodigiosa' or as a Mexican folk remedy for diabetes, is a plant in the daisy family traditionally brewed as a tea. Scientific evidence in humans is very limited, so its effectiveness and long-term safety are not well established. Talk with your pharmacist or doctor before using it, especially if you take medicines for blood sugar.

Brickellia grandiflora · Asteraceae · Leaves and flowering tops · Tea (infusion), dried herb, tincture, capsules

An interaction check asks whether these two react with each other — it does not ask whether Brickellia is a good idea for someone in your situation. Here is what our Brickellia record says about it on its own.

Brickellia: dosing

There is no established standardized dose for Brickellia. Traditional use is usually as a tea made from the dried leaves and flowering tops, but the strength of homemade preparations varies widely.If you choose to use a commercial product, follow the directions on the label and do not exceed them.

From our Brickellia monograph — the full record covers uses, side effects and every documented interaction.

Read the full Brickellia monograph & all interactions
Medication

About Lofexidine

What Is Lofexidine Used For?

Brand name: Lucemyra

Lofexidine tablets — sold under the brand name Lucemyra, as well as under the generic names lofexidine and lofexidine hydrochloride — are approved for adults to help manage the physical symptoms of opioid withdrawal when opioids are stopped suddenly.

It is not a treatment for opioid use disorder on its own. It is meant to be used as part of a broader, comprehensive treatment program.

Most-Reported Side Effects for Lofexidine Hydrochloride

From FAERS, the FDA’s public side-effect reporting system (161 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dizziness 24 reports
Hypotension 17 reports
Somnolence 15 reports
Dyspnea 14 reports
Diarrhea 12 reports
See full Lofexidine drug information
Keep checking

Other Drugs & Brickellia

Browse every other medication we’ve checked against Brickellia — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
0Minor
2,743No known interaction
86 Moderate 2,743 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Brickellia page.

No interaction 2,743 drugs checked — show the list

We also checked Brickellia against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Brickellia list.

See the full Brickellia interactions page
See every supplement checked against Lofexidine Hydrochloride, ranked by severity
Evidence & sources

Brickellia References

The 5 references that drive our Brickellia monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Rosler KH, Goodwin RS, Mabry TJ, et al. Flavonoids with anti-cataract activity from Brickellia arguta. J Nat Prod 1984;47:316-9. PubMed
  2. Andrade-Cetto A, Heinrich M. Mexican plants with hypoglycaemic effect used in the treatment of diabetes. J Ethnopharmacol 2005;99:325-48. PubMed
  3. Perez RM, Cervantes H, Zavala MA, et al. Isolation and hypoglycemic activity of 5, 7,3'-trihydroxy-3,6,4'-trimethoxyflavone from Brickellia veronicaefolia. Phytomedicine 2000;7:25-9.
  4. Escandón-Rivera S, González-Andrade M, Bye R, Linares E, Navarrete A, Mata R. α-glucosidase inhibitors from Brickellia cavanillesii. J Nat Prod. 2012;75(5):968-74.
  5. Palacios-Espinosa F, Déciga-Campos M, Mata R. Antinociceptive, hypoglycemic and spasmolytic effects of Brickellia veronicifolia. J Ethnopharmacol. 2008;118(3):448-54. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Brickellia and Lofexidine Hydrochloride Together: Common Questions

Is it safe to take Brickellia with Lofexidine Hydrochloride?
We do not list a known interaction between Brickellia and Lofexidine Hydrochloride. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Brickellia and Lofexidine Hydrochloride combination checked?
Interactions in our licensed database are recorded against drug classes. Lofexidine Hydrochloride is filed under 3 classifications, and Brickellia has documented interactions with 1 drug class — none of Lofexidine Hydrochloride's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Brickellia interact with any other medications?
Yes. Brickellia has 86 documented drug interactions in our database — Lofexidine Hydrochloride is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Lofexidine Hydrochloride interact with any supplements?
Yes. Lofexidine Hydrochloride has documented interactions with 139 supplements in our database — Brickellia is not one of them. The Lofexidine Hydrochloride interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Brickellia monograph Uses, safety profile, and every drug interaction in one place Lofexidine drug information The full plain-English guide to this medication Lofexidine Hydrochloride supplement interactions Every supplement checked against Lofexidine Hydrochloride, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 5 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Lofexidine Hydrochloride and Brickellia?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.