Lofexidine

78 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

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78 Major
All (78) Major (78)

Major

Lofexidine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of CNS depressant effects Details Lofexidine Amitriptyline Elavil Explained Increased risk of QT interval prolongation Details Lofexidine Sertraline Explained Increased risk of QT interval prolongation and an increased CYP2D6 substrate exposure Details Lofexidine Buprenorphine Belbuca Explained Increased risk of CNS depressant effects and increased risk of QT interval prolongation Details Lofexidine Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Lofexidine Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Lofexidine Arsenic Trioxide Trisenox Increased risk of QT interval prolongation Details Lofexidine Aripiprazole Injection Abilify Increased risk of CNS depressant effects and increased risk of QT interval prolongation Details Lofexidine Arsenic Trioxide Injection Trisenox Increased risk of QT interval prolongation Details Lofexidine Asenapine Transdermal Patch Secuado Increased risk of CNS depressant effects and increased risk of QT interval prolongation Details Lofexidine Azithromycin AzaSite Increased risk of QT interval prolongation Details Lofexidine Abiraterone Abirtega Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects Details Lofexidine Alfuzosin UroXatral Increased risk of QT interval prolongation Details Lofexidine Anagrelide Agrylin Increased risk of QT interval prolongation Details Lofexidine Bedaquiline Sirturo Increased risk of QT interval prolongation Details Lofexidine Butorphanol Injection Butorphic Increased risk of CNS depressant effects Details Lofexidine Butorphanol Nasal Spray Stadol® NS Increased risk of CNS depressant effects Details Lofexidine Chloroquine Aralen® Increased risk of QT interval prolongation Details Lofexidine Dasatinib Phyrago Increased risk of QT interval prolongation Details Lofexidine Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Lofexidine Deutetrabenazine Austedo Increased risk of QT interval prolongation Details Lofexidine Diazepam Nasal Spray Valtoco Increased risk of CNS depressant effects Details Lofexidine Diazepam Rectal Diastat Increased risk of CNS depressant effects Details Lofexidine Diphenhydramine Injection Banophen Increased risk of CNS depressant effects Details Lofexidine Diphenhydramine Topical Afterbite with Antihistamine Increased risk of CNS depressant effects Details Lofexidine Disopyramide Norpace Increased risk of QT interval prolongation Details Lofexidine Dofetilide Tikosyn Increased risk of QT interval prolongation Details Lofexidine Dolasetron Anzemet Increased risk of QT interval prolongation Details Lofexidine Dolasetron Injection Anzemet Increased risk of QT interval prolongation Details Lofexidine Encorafenib Braftovi Increased risk of QT interval prolongation Details Lofexidine Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Lofexidine Eribulin Injection Halaven Increased risk of QT interval prolongation Details Lofexidine Famotidine Calmicid Increased risk of QT interval prolongation Details Lofexidine Famotidine Injection Calmicid Increased risk of QT interval prolongation Details Lofexidine Felbamate Felbatol Increased risk of QT interval prolongation Details Lofexidine Fentanyl Transdermal Patch Duragesic® Increased risk of CNS depressant effects Details Lofexidine Flecainide Tambocor® Increased risk of QT interval prolongation Details Lofexidine Foscarnet Injection Foscavir Increased risk of QT interval prolongation Details Lofexidine Fostemsavir Rukobia Increased risk of torsade de pointes Details Lofexidine Galantamine Razadyne Increased risk of QT interval prolongation Details

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