Xanthoparmelia + Lofexidine Hydrochloride
Lofexidine Hydrochloride brand name: Lucemyra.
We found no known interaction between Xanthoparmelia and Lofexidine Hydrochloride in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Xanthoparmelia and Lofexidine Hydrochloride
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Lofexidine Hydrochloride and Xanthoparmelia in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Xanthoparmelia at all — not against Lofexidine Hydrochloride, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Xanthoparmelia safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Xanthoparmelia in Pregnancy & Breastfeeding
When used orally. Scabrosin esters contained in xanthoparmelia are considered toxic.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
See Every Supplement That Interacts With Lofexidine Hydrochloride
This page covers Xanthoparmelia only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Lofexidine Hydrochloride page lists 139 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).
By severity: 3 major · 95 moderate · 41 minor.
From our pharmacist’s overview on the Lofexidine Hydrochloride page
“Grapefruit is the supplement risk I would flag first for anyone taking lofexidine (Lucemyra) for opioid withdrawal. It blocks the enzyme (CYP3A4) that clears lofexidine, and higher levels can deepen the low blood pressure and drowsiness this drug already causes.”
Reviewed by 2 · Jul 18, 2026
Taking Xanthoparmelia as Part of a Dietary Supplement Product? Check It for Interactions
We hold 75 real supplement products containing Xanthoparmelia, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Xanthoparmelia. Even though Xanthoparmelia itself has no known interaction with Lofexidine Hydrochloride, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Xanthoparmelia and Lofexidine Hydrochloride Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#639 of 1,452 supplements looked up here in the last 7 days
#2,578 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Xanthoparmelia reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Xanthoparmelia and Lofexidine Hydrochloride records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Xanthoparmelia
What is Xanthoparmelia?
- Erectile dysfunction
- Sexual performance
- Libido support
- General 'male enhancement'
Xanthoparmelia is a type of lichen marketed mainly in supplements promoted for erectile dysfunction and sexual performance, but there is very little reliable human research to support these uses. Some 'male enhancement' products containing it have been found spiked with hidden prescription drugs, which is a real safety concern. Talk with your pharmacist or doctor before using it.
Xanthoparmelia scabrosa · Parmeliaceae · Whole lichen (thallus) · Capsules, tablets, powders (often in 'male enhancement' supplement blends)
An interaction check asks whether these two react with each other — it does not ask whether Xanthoparmelia is a good idea for someone in your situation. Here is what our Xanthoparmelia record says about it on its own.
Xanthoparmelia: dosing
There is no established or standardized dose of Xanthoparmelia. Amounts vary widely between products, and many are proprietary blends that do not clearly list how much lichen they contain.If you choose to use a product containing Xanthoparmelia, follow the label directions and do not exceed them.
From our Xanthoparmelia monograph — the full record covers uses, side effects and every documented interaction.
About Lofexidine
What Is Lofexidine Used For?
Brand name: Lucemyra
Lofexidine tablets — sold under the brand name Lucemyra, as well as under the generic names lofexidine and lofexidine hydrochloride — are approved for adults to help manage the physical symptoms of opioid withdrawal when opioids are stopped suddenly.
It is not a treatment for opioid use disorder on its own. It is meant to be used as part of a broader, comprehensive treatment program.
Most-Reported Side Effects for Lofexidine Hydrochloride
From FAERS, the FDA’s public side-effect reporting system (161 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Xanthoparmelia
Browse every other medication we’ve checked against Xanthoparmelia — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Xanthoparmelia against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Warfarin ›
- Methylphenidate ›
- Sertraline ›
- Abemaciclib ›
- Testosterone ›
- Ivermectin ›
- Acetaminophen ›
- Losartan Potassium ›
- Aspirin ›
- Metoprolol ›
- Rosuvastatin ›
- Clopidogrel ›
- Escitalopram ›
- Rivaroxaban ›
- Atorvastatin ›
- Docusate ›
- Ibuprofen ›
- Tirzepatide ›
- Methamphetamine ›
- Warfarin Sodium ›
- Tadalafil ›
- Valacyclovir ›
- Sumatriptan ›
- Hydroxyurea ›
- Prednisone ›
- Semaglutide ›
- Metformin ›
- Amitriptyline ›
- Propranolol ›
- Methotrexate ›
- Lisdexamfetamine ›
- Isotretinoin ›
- Amoxicillin ›
- Lisinopril ›
- Amlodipine Besylate ›
- Amphetamine ›
- Bupropion ›
- Bendamustine ›
- Fluoxetine ›
- Doxycycline ›
- Azithromycin ›
- Pregabalin ›
- Acyclovir ›
- Gabapentin ›
- Lamotrigine ›
- Dextroamphetamine ›
- Levothyroxine, Liothyronine ›
- Naproxen ›
- Acetaminophen, Codeine ›
- Clonazepam ›
- Quetiapine ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Citalopram ›
- Buspirone ›
- Methylene Blue ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Xanthoparmelia list.
Xanthoparmelia References
The 1 references that drive our Xanthoparmelia monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Moerman KL, Chai CL, Waring P. Evidence that the lichen-derived scabrosin esters target mitochondrial ATP synthase in P388D1 cells. Toxicol Appl Pharmacol 2003;190:232-40. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Xanthoparmelia and Lofexidine Hydrochloride Together: Common Questions
Is it safe to take Xanthoparmelia with Lofexidine Hydrochloride?
Does Lofexidine Hydrochloride interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Lofexidine Hydrochloride and Xanthoparmelia?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.