Crizotinib
Generic name: Pronounced as (kriz oh' ti nib)
Medical Content Reviewed By HelloPharmacist Staff
Last Revised - 04/15/2021
On this page
- Why is this medication prescribed?
- How should this medicine be used?
- Other uses for this medicine
- What special precautions should I follow?
- What special dietary instructions should I follow?
- What should I do if I forget a dose?
- What side effects can this medication cause?
- What should I know about STORAGE and DISPOSAL of this medication?
- What should I do in case of OVERDOSE?
- What OTHER INFORMATION should I know?
- Drug interactions
Why is this medication prescribed?
Crizotinib is used to treat certain types of non-small cell lung cancer (NSCLC) that has spread to nearby tissues or to other parts of the body. It is also used to treat a certain type of anaplastic large cell lymphoma (ALCL) that has returned or is unresponsive to other treatment(s) in certain adults and children 1 year of age and older. Crizotinib is in a class of medications called kinase inhibitors. It works by blocking the action of a certain naturally occurring substance that may be needed to help cancer cells multiply.
How should this medicine be used?
Crizotinib comes as a capsule to take by mouth. It is usually taken with or without food twice a day. Take crizotinib at around the same times every day. Follow the directions on your prescription label carefully and ask your doctor or pharmacist to explain any part you do not understand. Take crizotinib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Swallow the capsules whole; do not split, chew, or crush them. Do not touch capsules that are broken or crushed.
Your doctor may temporarily or permanently stop your treatment, decrease the dose, or tell you take your medication less often if you experience serious side effects of crizotinib. Tell your doctor how you are feeling during your treatment.
Continue to take crizotinib even if you feel well. Do not stop taking crizotinib without talking to your doctor.
Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.
Other uses for this medicine
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What special precautions should I follow?
Before taking crizotinib,
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tell your doctor and pharmacist if you are allergic to crizotinib, any other medications, or any of the ingredients in crizotinib capsules. Ask your pharmacist or check the manufacturer's patient information for a list of the ingredients.
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tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: amiodarone (Cordarone, Pacerone); certain antibiotics such as clarithromycin (Biaxin); certain antifungal medications such as itraconaozole (Sporanox), ketoconazole (Nizoral), and voriconazole (Vfend); certain blood pressure medications; chloroquine (Aralen); chlorpromazine (Thorazine); citalopram (Celexa); cyclosporine (Gengraf, Neoral, Sandimmune); digoxin (Lanoxin); dihydroergotamine (D.H.E. 45, Migranal); disopyramide (Norpace); dofetilide (Tikosyn); droperidol (Inapsine); ergotamine (Ergomar, in Cafergot, in Migergot); erythromycin (E.E.S., Erythrocin); fentanyl (Abstral, Actiq, Fentora, Lazanda, Onsolis); flecainide (Tambocor); certain medications for human immunodeficiency virus (HIV) such as atazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), and saquinavir (Invirase); certain medications for seizures such as carbamazepine (Carbatrol, Equetro, Tegretol), phenobarbital, and phenytoin (Dilantin); mesoridazine (Serentil); methadone (Dolophine); moxifloxacin (Avelox); nefazodone; pentamidine (NebuPent, Pentam); pimozide (Orap); procainamide (Pronestyl); quinidine (in Nuedexta); rifabutin (Mycobutin), rifampin (Rimactane, Rifadin, in Rifater); sirolimus (Rapamune); sotalol (Betapace); tacrolimus (Prograf); telithromycin (Ketek); thioridazine (Mellaril); and vandetanib (Caprelsa). Many other medications may also interact with crizotinib, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
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tell your doctor what herbal products you are taking, especially St. John's wort.
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tell your doctor if you have or have ever had long QT syndrome (a rare heart problem that may cause irregular heartbeat, fainting, or sudden death), a slow heartbeat, heart failure, vision problems, lung problems other than lung cancer, or liver or kidney disease.
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tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. You will need to have a pregnancy test before you start treatment with crizotinib. If you are female, you should use birth control during your treatment and for 45 days after your final dose. If you are male, you and your female partner should use birth control during your treatment and for 90 days after your final dose. Talk to your doctor about which method of birth control you should use. If you become pregnant while taking crizotinib, call your doctor immediately. Crizotinib may harm the fetus.
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tell your doctor if you are breastfeeding. Do not breastfeed during your treatment and for 45 days after your final dose.
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you should know that this medication may decrease fertility in men and women. Talk to your doctor about the risks of taking crizotinib.
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if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking crizotinib.
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you should know that crizotinib may cause vision problems, dizziness, and excessive tiredness. Do not drive a car or operate machinery until you know how this medication affects you.
What special dietary instructions should I follow?
Do not eat grapefruit or drink grapefruit juice while taking this medication.
What should I do if I forget a dose?
Take the missed dose as soon as you remember it. However, if it is less than 6 hours before you are scheduled to take your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can this medication cause?
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Crizotinib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
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diarrhea
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constipation
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stomach pain
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sores in the mouth
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change in ability to taste food
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heartburn
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headache
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numbness, burning, or tingling in the hands or feet
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difficulty falling asleep or staying asleep
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Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:
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shortness of breath
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cough
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fever
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swelling of the arms, hands, feet, ankles, or lower legs
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chest pain
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slow heartbeat
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rash
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weakness
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excessive tiredness
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pain in the right upper part of the stomach
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nausea
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vomiting
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difficulty swallowing
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yellowing of the skin or eyes
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dark urine
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itching
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fever
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unusual bleeding or bruising
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double or blurred vision
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changes in vision
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sensitivity to light
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seeing sudden flashes of light
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seeing new or increased floaters (spots in your vision)
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Crizotinib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
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If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
What should I know about STORAGE and DISPOSAL of this medication?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).
It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.
What should I do in case of OVERDOSE?
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
What OTHER INFORMATION should I know?
Keep all appointments with your doctor and the laboratory. Your doctor will order a lab test before you begin your treatment to see whether your cancer can be treated with crizotinib and will also order certain lab tests during your treatment to check your body's response to crizotinib. Your doctor will also check your heart rate and blood pressure regularly during your treatment.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Drug interactions
Drug | Interaction |
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Moxifloxacin | Moxifloxacin The risk or severity of QTc prolongation can be increased when Moxifloxacin is combined with Crizotinib. |
Delavirdine | Delavirdine The metabolism of Crizotinib can be decreased when combined with Delavirdine. |
Nevirapine | Nevirapine The metabolism of Nevirapine can be decreased when combined with Crizotinib. |
Atorvastatin | Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Crizotinib. |
Dolasetron | Dolasetron The risk or severity of QTc prolongation can be increased when Dolasetron is combined with Crizotinib. |
Aminophylline | Aminophylline The metabolism of Aminophylline can be decreased when combined with Crizotinib. |
Anagrelide | Anagrelide The risk or severity of QTc prolongation can be increased when Crizotinib is combined with Anagrelide. |
Cilostazol | Cilostazol The metabolism of Cilostazol can be decreased when combined with Crizotinib. |
Clopidogrel | Clopidogrel The metabolism of Clopidogrel can be decreased when combined with Crizotinib. |
Erythromycin and Sulfisoxazole | Erythromycin and Sulfisoxazole The serum concentration of Crizotinib can be increased when it is combined with Erythromycin. |
Fenofibrate | Fenofibrate The metabolism of Fenofibrate can be decreased when combined with Crizotinib. |
Guanfacine | Guanfacine Guanfacine may increase the bradycardic activities of Crizotinib. |
Methylergonovine | Methylergonovine The metabolism of Crizotinib can be decreased when combined with Methylergometrine. |
Paregoric | Paregoric The serum concentration of Morphine can be increased when it is combined with Crizotinib. |
Penbutolol | Penbutolol The risk or severity of QTc prolongation can be increased when Acebutolol is combined with Crizotinib. |
Ranitidine | Ranitidine The serum concentration of Ranitidine can be increased when it is combined with Crizotinib. |
Reserpine | Reserpine The serum concentration of Crizotinib can be increased when it is combined with Reserpine. |
Tacrolimus | Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Crizotinib. |
Tizanidine | Tizanidine The risk or severity of QTc prolongation can be increased when Tizanidine is combined with Crizotinib. |
Triamcinolone | Triamcinolone The metabolism of Triamcinolone can be increased when combined with Crizotinib. |
Doxycycline Injection | Doxycycline Injection The metabolism of Crizotinib can be decreased when combined with Doxycycline. |
Famotidine Injection | Famotidine Injection The risk or severity of QTc prolongation can be increased when Famotidine is combined with Crizotinib. |
Fluconazole Injection | Fluconazole Injection The serum concentration of Crizotinib can be increased when it is combined with Fluconazole. |
Foscarnet Injection | Foscarnet Injection The risk or severity of QTc prolongation can be increased when Foscarnet is combined with Crizotinib. |
Levofloxacin Injection | Levofloxacin Injection The risk or severity of QTc prolongation can be increased when Levofloxacin is combined with Crizotinib. |
Meperidine Injection | Meperidine Injection The metabolism of Meperidine can be increased when combined with Crizotinib. |
Methylprednisolone Injection | Methylprednisolone Injection The metabolism of Crizotinib can be increased when combined with Methylprednisolone. |
Metoclopramide Injection | Metoclopramide Injection The risk or severity of QTc prolongation can be increased when Metoclopramide is combined with Crizotinib. |
Metronidazole Injection | Metronidazole Injection The metabolism of Metronidazole can be decreased when combined with Crizotinib. |
Morphine Injection | Morphine Injection The serum concentration of Morphine can be increased when it is combined with Crizotinib. |
Cyclosporine | Cyclosporine The serum concentration of Cyclosporine can be increased when it is combined with Crizotinib. |
Ondansetron | Ondansetron The metabolism of Ondansetron can be decreased when combined with Crizotinib. |
Granisetron | Granisetron The risk or severity of QTc prolongation can be increased when Granisetron is combined with Crizotinib. |
Olanzapine | Olanzapine The risk or severity of QTc prolongation can be increased when Olanzapine is combined with Crizotinib. |
Dofetilide | Dofetilide The metabolism of Dofetilide can be decreased when combined with Crizotinib. |
Hydroxychloroquine | Hydroxychloroquine The risk or severity of QTc prolongation can be increased when Hydroxychloroquine is combined with Crizotinib. |
Orlistat | Orlistat The metabolism of Crizotinib can be increased when combined with Orlistat. |
Oxcarbazepine | Oxcarbazepine The metabolism of Crizotinib can be increased when combined with Oxcarbazepine. |
Zaleplon | Zaleplon The metabolism of Zaleplon can be decreased when combined with Crizotinib. |
Anakinra | Anakinra The metabolism of Crizotinib can be increased when combined with Anakinra. |
Desloratadine | Desloratadine The risk or severity of QTc prolongation can be increased when Desloratadine is combined with Crizotinib. |
Rivastigmine | Rivastigmine Rivastigmine may increase the bradycardic activities of Crizotinib. |
Trimipramine | Trimipramine The serum concentration of Crizotinib can be increased when it is combined with Trimipramine. |
Etanercept Injection | Etanercept Injection The metabolism of Crizotinib can be increased when combined with Etanercept. |
Modafinil | Modafinil The metabolism of Crizotinib can be increased when combined with Modafinil. |
Tenofovir | Tenofovir The metabolism of Tenofovir can be decreased when combined with Crizotinib. |
Sirolimus | Sirolimus The metabolism of Sirolimus can be decreased when combined with Crizotinib. |
Dutasteride | Dutasteride The metabolism of Dutasteride can be decreased when combined with Crizotinib. |
Epinephrine Injection | Epinephrine Injection The metabolism of Epinephrine can be decreased when combined with Crizotinib. |
Eplerenone | Eplerenone The metabolism of Eplerenone can be decreased when combined with Crizotinib. |
Escitalopram | Escitalopram The risk or severity of QTc prolongation can be increased when Crizotinib is combined with Escitalopram. |
Zonisamide | Zonisamide The serum concentration of Crizotinib can be increased when it is combined with Zonisamide. |
Adalimumab Injection | Adalimumab Injection The metabolism of Crizotinib can be increased when combined with Adalimumab. |
Aripiprazole | Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Crizotinib. |
Atomoxetine | Atomoxetine The risk or severity of QTc prolongation can be increased when Atomoxetine is combined with Crizotinib. |
Teriparatide Injection | Teriparatide Injection The therapeutic efficacy of Teriparatide can be decreased when used in combination with Crizotinib. |
Atazanavir | Atazanavir The metabolism of Crizotinib can be decreased when combined with Atazanavir. |
Mefloquine | Mefloquine The metabolism of Crizotinib can be decreased when combined with Mefloquine. |
Rosuvastatin | Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Crizotinib. |
Vardenafil | Vardenafil The metabolism of Vardenafil can be decreased when combined with Crizotinib. |
Alfuzosin | Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Crizotinib. |
Aprepitant | Aprepitant The metabolism of Crizotinib can be decreased when combined with Aprepitant. |
Memantine | Memantine The serum concentration of Memantine can be increased when it is combined with Crizotinib. |
Tegaserod | Tegaserod The serum concentration of Tegaserod can be increased when it is combined with Crizotinib. |
Tadalafil | Tadalafil The metabolism of Tadalafil can be decreased when combined with Crizotinib. |
Gemifloxacin | Gemifloxacin The risk or severity of QTc prolongation can be increased when Gemifloxacin is combined with Crizotinib. |
Progesterone | Progesterone The metabolism of Progesterone can be increased when combined with Crizotinib. |
Apomorphine Injection | Apomorphine Injection The metabolism of Crizotinib can be decreased when combined with Apomorphine. |
Darbepoetin Alfa Injection | Darbepoetin Alfa Injection The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Crizotinib. |
Infliximab Injection | Infliximab Injection The metabolism of Crizotinib can be increased when combined with Infliximab. |
Protriptyline | Protriptyline The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Crizotinib. |
Rifaximin | Rifaximin The serum concentration of Rifaximin can be increased when it is combined with Crizotinib. |
Duloxetine | Duloxetine The metabolism of Duloxetine can be decreased when combined with Crizotinib. |
Norethindrone | Norethindrone The metabolism of Norethisterone can be decreased when combined with Crizotinib. |
Bosentan | Bosentan The metabolism of Crizotinib can be increased when combined with Bosentan. |
Erlotinib | Erlotinib The metabolism of Erlotinib can be decreased when combined with Crizotinib. |
Eszopiclone | Eszopiclone The metabolism of Eszopiclone can be decreased when combined with Crizotinib. |
Solifenacin | Solifenacin The risk or severity of QTc prolongation can be increased when Solifenacin is combined with Crizotinib. |
Voriconazole | Voriconazole The metabolism of Crizotinib can be decreased when combined with Voriconazole. |
Ibandronate | Ibandronate The risk or severity of QTc prolongation can be increased when Ibandronate is combined with Crizotinib. |
Fentanyl | Fentanyl The metabolism of Fentanyl can be decreased when combined with Crizotinib. |
Pregabalin | Pregabalin The risk or severity of QTc prolongation can be increased when Pregabalin is combined with Crizotinib. |
Deferasirox | Deferasirox The metabolism of Crizotinib can be increased when combined with Deferasirox. |
Tipranavir | Tipranavir The serum concentration of Crizotinib can be increased when it is combined with Tipranavir. |
Felbamate | Felbamate The metabolism of Crizotinib can be increased when combined with Felbamate. |
Ranolazine | Ranolazine The serum concentration of Crizotinib can be increased when it is combined with Ranolazine. |
Abatacept Injection | Abatacept Injection The metabolism of Crizotinib can be increased when combined with Abatacept. |
Imatinib | Imatinib The metabolism of Crizotinib can be decreased when combined with Imatinib. |
Sitagliptin | Sitagliptin The serum concentration of Sitagliptin can be increased when it is combined with Crizotinib. |
Varenicline | Varenicline The excretion of Varenicline can be decreased when combined with Crizotinib. |
Gefitinib | Gefitinib The metabolism of Gefitinib can be decreased when combined with Crizotinib. |
Albuterol | Albuterol The risk or severity of QTc prolongation can be increased when Salbutamol is combined with Crizotinib. |
Paliperidone | Paliperidone The serum concentration of Paliperidone can be increased when it is combined with Crizotinib. |
Bortezomib | Bortezomib The metabolism of Crizotinib can be decreased when combined with Bortezomib. |
Clofarabine Injection | Clofarabine Injection The serum concentration of Clofarabine can be increased when it is combined with Crizotinib. |
Oxaliplatin Injection | Oxaliplatin Injection The serum concentration of Oxaliplatin can be increased when it is combined with Crizotinib. |
Posaconazole | Posaconazole The metabolism of Crizotinib can be decreased when combined with Posaconazole. |
Primaquine | Primaquine The metabolism of Crizotinib can be decreased when combined with Primaquine. |
Darunavir | Darunavir The serum concentration of Crizotinib can be increased when it is combined with Darunavir. |
Dimenhydrinate | Dimenhydrinate The risk or severity of QTc prolongation can be increased when Dimenhydrinate is combined with Crizotinib. |
Retapamulin | Retapamulin The metabolism of Retapamulin can be decreased when combined with Crizotinib. |
Vorinostat | Vorinostat The risk or severity of QTc prolongation can be increased when Vorinostat is combined with Crizotinib. |
Sorafenib | Sorafenib The metabolism of Crizotinib can be decreased when combined with Sorafenib. |
Sunitinib | Sunitinib The metabolism of Sunitinib can be decreased when combined with Crizotinib. |
Lapatinib | Lapatinib The serum concentration of Crizotinib can be increased when it is combined with Lapatinib. |
Levocetirizine | Levocetirizine The risk or severity of QTc prolongation can be increased when Levocetirizine is combined with Crizotinib. |
Dasatinib | Dasatinib The metabolism of Dasatinib can be decreased when combined with Crizotinib. |
Armodafinil | Armodafinil The metabolism of Crizotinib can be increased when combined with Armodafinil. |
Ivermectin | Ivermectin The metabolism of Crizotinib can be increased when combined with Ivermectin. |
Temsirolimus | Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Crizotinib. |
Nilotinib | Nilotinib The metabolism of Nilotinib can be decreased when combined with Crizotinib. |
Toremifene | Toremifene The serum concentration of Toremifene can be increased when it is combined with Crizotinib. |
Bexarotene | Bexarotene The metabolism of Crizotinib can be increased when combined with Bexarotene. |
Budesonide | Budesonide The metabolism of Crizotinib can be increased when combined with Budesonide. |
Chloramphenicol Injection | Chloramphenicol Injection The metabolism of Crizotinib can be decreased when combined with Chloramphenicol. |
Etravirine | Etravirine The metabolism of Crizotinib can be increased when combined with Etravirine. |
Arsenic Trioxide Injection | Arsenic Trioxide Injection The risk or severity of QTc prolongation can be increased when Crizotinib is combined with Arsenic trioxide. |
Mitoxantrone Injection | Mitoxantrone Injection The metabolism of Crizotinib can be decreased when combined with Mitoxantrone. |
Desvenlafaxine | Desvenlafaxine The metabolism of Crizotinib can be decreased when combined with Desvenlafaxine. |
Nebivolol | Nebivolol Nebivolol may increase the bradycardic activities of Crizotinib. |
Tretinoin | Tretinoin The metabolism of Tretinoin can be decreased when combined with Crizotinib. |
Bendamustine Injection | Bendamustine Injection The serum concentration of Bendamustine can be increased when it is combined with Crizotinib. |
Pilocarpine | Pilocarpine The metabolism of Crizotinib can be decreased when combined with Pilocarpine. |
Flecainide | Flecainide The risk or severity of QTc prolongation can be increased when Flecainide is combined with Crizotinib. |
Certolizumab Injection | Certolizumab Injection The metabolism of Crizotinib can be increased when combined with Certolizumab pegol. |
Ixabepilone Injection | Ixabepilone Injection The metabolism of Ixabepilone can be decreased when combined with Crizotinib. |
Irinotecan Injection | Irinotecan Injection The metabolism of Irinotecan can be decreased when combined with Crizotinib. |
Praziquantel | Praziquantel The metabolism of Praziquantel can be decreased when combined with Crizotinib. |
Mitotane | Mitotane The metabolism of Crizotinib can be increased when combined with Mitotane. |
Rufinamide | Rufinamide The metabolism of Rufinamide can be increased when combined with Crizotinib. |
Silodosin | Silodosin The serum concentration of Silodosin can be increased when it is combined with Crizotinib. |
Midazolam | Midazolam The serum concentration of Midazolam can be increased when it is combined with Crizotinib. |
Milnacipran | Milnacipran The metabolism of Crizotinib can be decreased when combined with Milnacipran. |
Degarelix Injection | Degarelix Injection The risk or severity of QTc prolongation can be increased when Degarelix is combined with Crizotinib. |
Betaxolol | Betaxolol The risk or severity of QTc prolongation can be increased when Betaxolol is combined with Crizotinib. |
Iloperidone | Iloperidone The metabolism of Iloperidone can be decreased when combined with Crizotinib. |
Lacosamide | Lacosamide The metabolism of Lacosamide can be decreased when combined with Crizotinib. |
Everolimus | Everolimus The metabolism of Everolimus can be decreased when combined with Crizotinib. |
Tolvaptan (low blood sodium) | Tolvaptan (low blood sodium) The metabolism of Tolvaptan can be decreased when combined with Crizotinib. |
Dronedarone | Dronedarone The metabolism of Dronedarone can be decreased when combined with Crizotinib. |
Saxagliptin | Saxagliptin The metabolism of Saxagliptin can be decreased when combined with Crizotinib. |
Telavancin Injection | Telavancin Injection The risk or severity of QTc prolongation can be increased when Telavancin is combined with Crizotinib. |
Romidepsin Injection | Romidepsin Injection The metabolism of Romidepsin can be decreased when combined with Crizotinib. |
Topotecan | Topotecan The serum concentration of Topotecan can be increased when it is combined with Crizotinib. |
Golimumab Injection | Golimumab Injection The metabolism of Crizotinib can be increased when combined with Golimumab. |
Pazopanib | Pazopanib The serum concentration of Pazopanib can be increased when it is combined with Crizotinib. |
Asenapine | Asenapine The risk or severity of QTc prolongation can be increased when Crizotinib is combined with Asenapine. |
Albendazole | Albendazole The metabolism of Albendazole can be decreased when combined with Crizotinib. |
Levonorgestrel | Levonorgestrel The metabolism of Levonorgestrel can be decreased when combined with Crizotinib. |
Tocilizumab Injection | Tocilizumab Injection The metabolism of Crizotinib can be increased when combined with Tocilizumab. |
Dalfampridine | Dalfampridine The serum concentration of Dalfampridine can be increased when it is combined with Crizotinib. |
Fingolimod | Fingolimod Crizotinib may increase the bradycardic activities of Fingolimod. |
Eribulin Injection | Eribulin Injection The risk or severity of QTc prolongation can be increased when Eribulin is combined with Crizotinib. |
Cabazitaxel Injection | Cabazitaxel Injection The metabolism of Crizotinib can be decreased when combined with Cabazitaxel. |
Lurasidone | Lurasidone The metabolism of Lurasidone can be decreased when combined with Crizotinib. |
Acetaminophen Injection | Acetaminophen Injection The metabolism of Acetaminophen can be increased when combined with Crizotinib. |
Denileukin Diftitox Injection | Denileukin Diftitox Injection The metabolism of Crizotinib can be decreased when combined with Aldesleukin. |
Terbutaline Injection | Terbutaline Injection The risk or severity of QTc prolongation can be increased when Terbutaline is combined with Crizotinib. |
Busulfan Injection | Busulfan Injection The metabolism of Busulfan can be decreased when combined with Crizotinib. |
Roflumilast | Roflumilast The metabolism of Roflumilast can be decreased when combined with Crizotinib. |
Linagliptin | Linagliptin The serum concentration of Linagliptin can be increased when it is combined with Crizotinib. |
Rilpivirine | Rilpivirine The metabolism of Crizotinib can be decreased when combined with Rilpivirine. |
Telaprevir | Telaprevir The serum concentration of Glecaprevir can be increased when it is combined with Crizotinib. |
Potassium Iodide | Potassium Iodide The therapeutic efficacy of Potassium Iodide can be decreased when used in combination with Crizotinib. |
Cyclophosphamide Injection | Cyclophosphamide Injection The metabolism of Cyclophosphamide can be decreased when combined with Crizotinib. |
Triptorelin Injection | Triptorelin Injection The risk or severity of QTc prolongation can be increased when Triptorelin is combined with Crizotinib. |
Rivaroxaban | Rivaroxaban The metabolism of Rivaroxaban can be decreased when combined with Crizotinib. |
Ticagrelor | Ticagrelor The serum concentration of Crizotinib can be increased when it is combined with Ticagrelor. |
Brentuximab Vedotin Injection | Brentuximab Vedotin Injection The metabolism of Brentuximab vedotin can be decreased when combined with Crizotinib. |
Ruxolitinib | Ruxolitinib The metabolism of Crizotinib can be decreased when combined with Ruxolitinib. |
Vandetanib | Vandetanib The metabolism of Vandetanib can be decreased when combined with Crizotinib. |
Clobazam | Clobazam The metabolism of Clobazam can be increased when combined with Crizotinib. |
Vemurafenib | Vemurafenib The serum concentration of Crizotinib can be increased when it is combined with Vemurafenib. |
Ivacaftor | Ivacaftor The metabolism of Crizotinib can be decreased when combined with Ivacaftor. |
Axitinib | Axitinib The metabolism of Axitinib can be decreased when combined with Crizotinib. |
Cabergoline | Cabergoline The metabolism of Cabergoline can be decreased when combined with Crizotinib. |
Naloxone Injection | Naloxone Injection The metabolism of Crizotinib can be decreased when combined with Naloxone. |
Ambrisentan | Ambrisentan The metabolism of Ambrisentan can be decreased when combined with Crizotinib. |
Carfilzomib Injection | Carfilzomib Injection The serum concentration of Carfilzomib can be increased when it is combined with Crizotinib. |
Enzalutamide | Enzalutamide The serum concentration of Crizotinib can be increased when it is combined with Enzalutamide. |
Mirabegron | Mirabegron The serum concentration of Mirabegron can be increased when it is combined with Crizotinib. |
Regorafenib | Regorafenib The metabolism of Regorafenib can be decreased when combined with Crizotinib. |
Bosutinib | Bosutinib The serum concentration of Bosutinib can be increased when it is combined with Crizotinib. |
Corticotropin, Repository Injection | Corticotropin, Repository Injection The metabolism of Crizotinib can be increased when combined with Corticotropin. |
Bedaquiline | Bedaquiline The risk or severity of QTc prolongation can be increased when Crizotinib is combined with Bedaquiline. |
Tofacitinib | Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Crizotinib. |
Ponatinib | Ponatinib The metabolism of Ponatinib can be decreased when combined with Crizotinib. |
Pomalidomide | Pomalidomide The metabolism of Pomalidomide can be decreased when combined with Crizotinib. |
Ado-trastuzumab Emtansine Injection | Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be decreased when combined with Crizotinib. |
Apixaban | Apixaban The metabolism of Apixaban can be decreased when combined with Crizotinib. |
Canagliflozin | Canagliflozin The serum concentration of Canagliflozin can be increased when it is combined with Crizotinib. |
Dabrafenib | Dabrafenib The metabolism of Dabrafenib can be decreased when combined with Crizotinib. |
Trametinib | Trametinib The metabolism of Crizotinib can be increased when combined with Trametinib. |
Dolutegravir | Dolutegravir The serum concentration of Dolutegravir can be increased when it is combined with Crizotinib. |
Afatinib | Afatinib The serum concentration of Afatinib can be increased when it is combined with Crizotinib. |
Vortioxetine | Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Crizotinib. |
Perampanel | Perampanel The metabolism of Perampanel can be increased when combined with Crizotinib. |
Ibrutinib | Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Crizotinib. |
Lomitapide | Lomitapide The metabolism of Lomitapide can be decreased when combined with Crizotinib. |
Avanafil | Avanafil The metabolism of Avanafil can be decreased when combined with Crizotinib. |
Simeprevir | Simeprevir The serum concentration of Crizotinib can be increased when it is combined with Simeprevir. |
Sofosbuvir | Sofosbuvir The serum concentration of Sofosbuvir can be increased when it is combined with Crizotinib. |
Apremilast | Apremilast The metabolism of Crizotinib can be increased when combined with Apremilast. |
Ceritinib | Ceritinib Crizotinib may increase the bradycardic activities of Ceritinib. |
Siltuximab Injection | Siltuximab Injection The metabolism of Crizotinib can be increased when combined with Siltuximab. |
Eslicarbazepine | Eslicarbazepine The metabolism of Crizotinib can be increased when combined with Eslicarbazepine. |
Belinostat Injection | Belinostat Injection The serum concentration of Belinostat can be increased when it is combined with Crizotinib. |
Idelalisib | Idelalisib The metabolism of Crizotinib can be decreased when combined with Idelalisib. |
Testosterone Injection | Testosterone Injection The metabolism of Testosterone can be increased when combined with Crizotinib. |
Oritavancin Injection | Oritavancin Injection The metabolism of Crizotinib can be increased when combined with Oritavancin. |
Vorapaxar | Vorapaxar The serum concentration of Crizotinib can be increased when it is combined with Vorapaxar. |
Suvorexant | Suvorexant The serum concentration of Crizotinib can be increased when it is combined with Suvorexant. |
Edoxaban | Edoxaban The serum concentration of Edoxaban can be increased when it is combined with Crizotinib. |
Olaparib | Olaparib The metabolism of Olaparib can be decreased when combined with Crizotinib. |
Tasimelteon | Tasimelteon The metabolism of Tasimelteon can be decreased when combined with Crizotinib. |
Lanreotide Injection | Lanreotide Injection The metabolism of Crizotinib can be decreased when combined with Lanreotide. |
Nintedanib | Nintedanib The metabolism of Nintedanib can be decreased when combined with Crizotinib. |
Secukinumab Injection | Secukinumab Injection The metabolism of Crizotinib can be increased when combined with Secukinumab. |
Risperidone Injection | Risperidone Injection The metabolism of Risperidone can be decreased when combined with Crizotinib. |
Palbociclib | Palbociclib The metabolism of Palbociclib can be decreased when combined with Crizotinib. |
Lenvatinib | Lenvatinib The metabolism of Lenvatinib can be increased when combined with Crizotinib. |
Naloxegol | Naloxegol The serum concentration of Naloxegol can be increased when it is combined with Crizotinib. |
Panobinostat | Panobinostat The metabolism of Panobinostat can be decreased when combined with Crizotinib. |
Haloperidol Injection | Haloperidol Injection The risk or severity of QTc prolongation can be increased when Crizotinib is combined with Haloperidol. |
Ivabradine | Ivabradine The metabolism of Ivabradine can be decreased when combined with Crizotinib. |
Isavuconazonium Injection | Isavuconazonium Injection The serum concentration of Crizotinib can be increased when it is combined with Isavuconazonium. |
Sonidegib | Sonidegib The metabolism of Sonidegib can be decreased when combined with Crizotinib. |
Flibanserin | Flibanserin The metabolism of Crizotinib can be decreased when combined with Flibanserin. |
Rolapitant | Rolapitant The serum concentration of Crizotinib can be increased when it is combined with Rolapitant. |
Prednisolone | Prednisolone The metabolism of Crizotinib can be increased when combined with Prednisolone. |
Daclatasvir | Daclatasvir The serum concentration of Crizotinib can be increased when it is combined with Daclatasvir. |
Brexpiprazole | Brexpiprazole The metabolism of Brexpiprazole can be decreased when combined with Crizotinib. |
Ziprasidone Injection | Ziprasidone Injection The risk or severity of QTc prolongation can be increased when Crizotinib is combined with Ziprasidone. |
Cobimetinib | Cobimetinib The metabolism of Cobimetinib can be decreased when combined with Crizotinib. |
Trabectedin Injection | Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Crizotinib. |
Osimertinib | Osimertinib The metabolism of Osimertinib can be decreased when combined with Crizotinib. |
Alectinib | Alectinib The metabolism of Alectinib can be decreased when combined with Crizotinib. |
Ixazomib | Ixazomib The metabolism of Ixazomib can be decreased when combined with Crizotinib. |
Rifapentine | Rifapentine The metabolism of Crizotinib can be increased when combined with Rifapentine. |
Lesinurad | Lesinurad The metabolism of Crizotinib can be increased when combined with Lesinurad. |
Amphotericin B Liposomal Injection | Amphotericin B Liposomal Injection The metabolism of Crizotinib can be decreased when combined with Amphotericin B. |
Dexamethasone Injection | Dexamethasone Injection The metabolism of Dexamethasone can be increased when combined with Crizotinib. |
Venetoclax | Venetoclax The metabolism of Venetoclax can be decreased when combined with Crizotinib. |
Cobicistat | Cobicistat The serum concentration of Crizotinib can be increased when it is combined with Cobicistat. |
Midodrine | Midodrine Midodrine may increase the bradycardic activities of Crizotinib. |
Selexipag | Selexipag The serum concentration of Selexipag can be increased when it is combined with Crizotinib. |
Diphenhydramine Injection | Diphenhydramine Injection The risk or severity of QTc prolongation can be increased when Diphenhydramine is combined with Crizotinib. |
Rucaparib | Rucaparib The serum concentration of Rucaparib can be increased when it is combined with Crizotinib. |
Ribociclib | Ribociclib The metabolism of Ribociclib can be decreased when combined with Crizotinib. |
Parathyroid Hormone Injection | Parathyroid Hormone Injection The therapeutic efficacy of Parathyroid hormone can be decreased when used in combination with Crizotinib. |
Brigatinib | Brigatinib The metabolism of Brigatinib can be decreased when combined with Crizotinib. |
Doxepin (Insomnia) | Doxepin (Insomnia) The risk or severity of QTc prolongation can be increased when Doxepin is combined with Crizotinib. |
Deutetrabenazine | Deutetrabenazine The metabolism of Deutetrabenazine can be decreased when combined with Crizotinib. |
Valbenazine | Valbenazine The metabolism of Valbenazine can be decreased when combined with Crizotinib. |
Deflazacort | Deflazacort The serum concentration of Crizotinib can be increased when it is combined with Deflazacort. |
Safinamide | Safinamide The metabolism of Crizotinib can be decreased when combined with Safinamide. |
Sarilumab Injection | Sarilumab Injection The metabolism of Crizotinib can be increased when combined with Sarilumab. |
Midostaurin | Midostaurin The metabolism of Crizotinib can be decreased when combined with Midostaurin. |
Neratinib | Neratinib The metabolism of Crizotinib can be decreased when combined with Neratinib. |
Abaloparatide Injection | Abaloparatide Injection The therapeutic efficacy of Abaloparatide can be decreased when used in combination with Crizotinib. |
Enasidenib | Enasidenib The metabolism of Crizotinib can be decreased when combined with Enasidenib. |
Inotuzumab Ozogamicin Injection | Inotuzumab Ozogamicin Injection The serum concentration of Inotuzumab ozogamicin can be increased when it is combined with Crizotinib. |
Aprepitant/Fosaprepitant Injection | Aprepitant/Fosaprepitant Injection The metabolism of Fosaprepitant can be increased when combined with Crizotinib. |
Copanlisib Injection | Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Crizotinib. |
Delafloxacin | Delafloxacin The risk or severity of QTc prolongation can be increased when Delafloxacin is combined with Crizotinib. |
Abemaciclib | Abemaciclib The metabolism of Abemaciclib can be decreased when combined with Crizotinib. |
Betrixaban | Betrixaban The serum concentration of Betrixaban can be increased when it is combined with Crizotinib. |
Acalabrutinib | Acalabrutinib The metabolism of Crizotinib can be decreased when combined with Acalabrutinib. |
Letermovir | Letermovir The metabolism of Crizotinib can be decreased when combined with Letermovir. |
Tetrabenazine | Tetrabenazine The risk or severity of QTc prolongation can be increased when Crizotinib is combined with Tetrabenazine. |
Ertugliflozin | Ertugliflozin The serum concentration of Ertugliflozin can be increased when it is combined with Crizotinib. |
Buprenorphine Injection | Buprenorphine Injection The metabolism of Buprenorphine can be decreased when combined with Crizotinib. |
Apalutamide | Apalutamide The serum concentration of Crizotinib can be decreased when it is combined with Apalutamide. |
Fostamatinib | Fostamatinib The metabolism of Crizotinib can be decreased when combined with Fostamatinib. |
Avatrombopag | Avatrombopag The serum concentration of Avatrombopag can be increased when it is combined with Crizotinib. |
Baricitinib | Baricitinib The metabolism of Baricitinib can be decreased when combined with Crizotinib. |
Lofexidine | Lofexidine The risk or severity of QTc prolongation can be increased when Lofexidine is combined with Crizotinib. |
Eliglustat | Eliglustat The metabolism of Eliglustat can be decreased when combined with Crizotinib. |
Encorafenib | Encorafenib The risk or severity of QTc prolongation can be increased when Crizotinib is combined with Encorafenib. |
Binimetinib | Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Crizotinib. |
Ivosidenib | Ivosidenib The metabolism of Ivosidenib can be decreased when combined with Crizotinib. |
Lusutrombopag | Lusutrombopag The serum concentration of Lusutrombopag can be increased when it is combined with Crizotinib. |
Elagolix | Elagolix The serum concentration of Elagolix can be increased when it is combined with Crizotinib. |
Doravirine | Doravirine The metabolism of Doravirine can be decreased when combined with Crizotinib. |
Cannabidiol | Cannabidiol The metabolism of Cannabidiol can be decreased when combined with Crizotinib. |
Dacomitinib | Dacomitinib The metabolism of Dacomitinib can be decreased when combined with Crizotinib. |
Duvelisib | Duvelisib The metabolism of Duvelisib can be decreased when combined with Crizotinib. |
Omadacycline | Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Crizotinib. |
Sarecycline | Sarecycline The serum concentration of Crizotinib can be increased when it is combined with Sarecycline. |
Stiripentol | Stiripentol The metabolism of Crizotinib can be decreased when combined with Stiripentol. |
Talazoparib | Talazoparib The serum concentration of Talazoparib can be increased when it is combined with Crizotinib. |
Gilteritinib | Gilteritinib The metabolism of Gilteritinib can be decreased when combined with Crizotinib. |
Glasdegib | Glasdegib The serum concentration of Glasdegib can be increased when it is combined with Crizotinib. |
Lorlatinib | Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Crizotinib. |
Larotrectinib | Larotrectinib The serum concentration of Larotrectinib can be increased when it is combined with Crizotinib. |
Methoxy Polyethylene Glycol-Epoetin Beta Injection | Methoxy Polyethylene Glycol-Epoetin Beta Injection The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Crizotinib. |
Paclitaxel (with albumin) Injection | Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Crizotinib. |
Rifamycin | Rifamycin The serum concentration of Rifamycin can be increased when it is combined with Crizotinib. |
Prucalopride | Prucalopride The serum concentration of Prucalopride can be increased when it is combined with Crizotinib. |
Emapalumab-lzsg Injection | Emapalumab-lzsg Injection The metabolism of Crizotinib can be increased when combined with Emapalumab. |
Siponimod | Siponimod The risk or severity of adverse effects can be increased when Crizotinib is combined with Siponimod. |
Erdafitinib | Erdafitinib The metabolism of Crizotinib can be decreased when combined with Erdafitinib. |
Alpelisib | Alpelisib The metabolism of Alpelisib can be decreased when combined with Crizotinib. |
Solriamfetol | Solriamfetol The serum concentration of Solriamfetol can be increased when it is combined with Crizotinib. |
Darolutamide | Darolutamide The serum concentration of Darolutamide can be increased when it is combined with Crizotinib. |
Triclabendazole | Triclabendazole The metabolism of Crizotinib can be decreased when combined with Triclabendazole. |
Entrectinib | Entrectinib The metabolism of Entrectinib can be decreased when combined with Crizotinib. |
Pexidartinib | Pexidartinib The metabolism of Pexidartinib can be decreased when combined with Crizotinib. |
Istradefylline | Istradefylline The serum concentration of Istradefylline can be increased when it is combined with Crizotinib. |
Pitolisant | Pitolisant The serum concentration of Crizotinib can be decreased when it is combined with Pitolisant. |
Pretomanid | Pretomanid The serum concentration of Pretomanid can be increased when it is combined with Crizotinib. |
Fedratinib | Fedratinib The serum concentration of Fedratinib can be increased when it is combined with Crizotinib. |
Lefamulin | Lefamulin Crizotinib may increase the QTc-prolonging activities of Lefamulin. |
Phenytoin Injection | Phenytoin Injection The metabolism of Phenytoin can be increased when combined with Crizotinib. |
Fosphenytoin Injection | Fosphenytoin Injection The metabolism of Crizotinib can be decreased when combined with Fosphenytoin. |
Enfortumab vedotin-ejfv Injection | Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be increased when it is combined with Crizotinib. |
Zanubrutinib | Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Crizotinib. |
Voxelotor | Voxelotor The serum concentration of Voxelotor can be increased when it is combined with Crizotinib. |
Lumateperone | Lumateperone The serum concentration of Lumateperone can be increased when it is combined with Crizotinib. |
Lasmiditan | Lasmiditan The serum concentration of Crizotinib can be increased when it is combined with Lasmiditan. |
Ubrogepant | Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Crizotinib. |
Tazemetostat | Tazemetostat The metabolism of Tazemetostat can be decreased when combined with Crizotinib. |
Cenobamate | Cenobamate The serum concentration of Crizotinib can be decreased when it is combined with Cenobamate. |
Pemigatinib | Pemigatinib The metabolism of Pemigatinib can be decreased when combined with Crizotinib. |
Selumetinib | Selumetinib The serum concentration of Selumetinib can be increased when it is combined with Crizotinib. |
Rimegepant | Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Crizotinib. |
Tucatinib | Tucatinib Crizotinib may decrease the excretion rate of Tucatinib which could result in a higher serum level. |
Remdesivir Injection | Remdesivir Injection The serum concentration of Remdesivir can be increased when it is combined with Crizotinib. |
Ripretinib | Ripretinib The serum concentration of Ripretinib can be increased when it is combined with Crizotinib. |
Selpercatinib | Selpercatinib The serum concentration of Selpercatinib can be increased when it is combined with Crizotinib. |
Capmatinib | Capmatinib The serum concentration of Crizotinib can be increased when it is combined with Capmatinib. |
Lemborexant | Lemborexant The serum concentration of Lemborexant can be increased when it is combined with Crizotinib. |
Fostemsavir | Fostemsavir The risk or severity of QTc prolongation can be increased when Fostemsavir is combined with Crizotinib. |
Lurbinectedin Injection | Lurbinectedin Injection The serum concentration of Lurbinectedin can be increased when it is combined with Crizotinib. |
Octreotide | Octreotide The serum concentration of the active metabolites of Crizotinib can be increased when Crizotinib is used in combination with Octreotide. |
Belantamab Mafodotin-blmf Injection | Belantamab Mafodotin-blmf Injection The serum concentration of Belantamab mafodotin can be increased when it is combined with Crizotinib. |
Pralsetinib | Pralsetinib The serum concentration of Pralsetinib can be increased when it is combined with Crizotinib. |
Satralizumab-mwge Injection | Satralizumab-mwge Injection The serum concentration of Crizotinib can be decreased when it is combined with Satralizumab. |
Relugolix | Relugolix The serum concentration of Relugolix can be increased when it is combined with Crizotinib. |
Progestin-Only (drospirenone) Oral Contraceptives | Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Crizotinib can be decreased when combined with Drospirenone. |
Vitamin E (Alpha-Tocopherol) | Vitamin E (Alpha-Tocopherol) The metabolism of Crizotinib can be increased when combined with Vitamin E. |
Theophylline | Theophylline The metabolism of Theophylline can be decreased when combined with Crizotinib. |
Trazodone | Trazodone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Crizotinib. |
Phenobarbital | Phenobarbital The metabolism of Crizotinib can be increased when combined with Phenobarbital. |
Methotrexate Injection | Methotrexate Injection The metabolism of Methotrexate can be decreased when combined with Crizotinib. |
Primidone | Primidone The metabolism of Crizotinib can be increased when combined with Primidone. |
Methsuximide | Methsuximide The risk or severity of QTc prolongation can be increased when Methsuximide is combined with Crizotinib. |
Chlorpromazine | Chlorpromazine The metabolism of Chlorpromazine can be increased when combined with Crizotinib. |
Diazepam | Diazepam The metabolism of Diazepam can be decreased when combined with Crizotinib. |
Lorazepam | Lorazepam The metabolism of Lorazepam can be decreased when combined with Crizotinib. |
Amantadine | Amantadine The risk or severity of QTc prolongation can be increased when Amantadine is combined with Crizotinib. |
Bromocriptine | Bromocriptine The metabolism of Crizotinib can be decreased when combined with Bromocriptine. |
Tranylcypromine | Tranylcypromine The metabolism of Crizotinib can be decreased when combined with Tranylcypromine. |
Phenelzine | Phenelzine The metabolism of Crizotinib can be decreased when combined with Phenelzine. |
Tetracycline | Tetracycline The metabolism of Crizotinib can be decreased when combined with Tetracycline. |
Prochlorperazine | Prochlorperazine The metabolism of Crizotinib can be decreased when combined with Prochlorperazine. |
Thioridazine | Thioridazine The risk or severity of QTc prolongation can be increased when Crizotinib is combined with Thioridazine. |
Dapsone | Dapsone The metabolism of Dapsone can be decreased when combined with Crizotinib. |
Oxycodone | Oxycodone The metabolism of Oxycodone can be decreased when combined with Crizotinib. |
Methadone | Methadone The metabolism of Methadone can be increased when combined with Crizotinib. |
Oxybutynin | Oxybutynin The metabolism of Oxybutynin can be decreased when combined with Crizotinib. |
Benztropine | Benztropine The risk or severity of QTc prolongation can be increased when Benzatropine is combined with Crizotinib. |
Maprotiline | Maprotiline The risk or severity of QTc prolongation can be increased when Maprotiline is combined with Crizotinib. |
Orphenadrine | Orphenadrine The metabolism of Crizotinib can be decreased when combined with Orphenadrine. |
Phentermine | Phentermine The metabolism of Phentermine can be decreased when combined with Crizotinib. |
Amoxapine | Amoxapine The risk or severity of QTc prolongation can be increased when Amoxapine is combined with Crizotinib. |
Hydrocortisone | Hydrocortisone The metabolism of Hydrocortisone can be increased when combined with Crizotinib. |
Doxorubicin | Doxorubicin The metabolism of Doxorubicin can be decreased when combined with Crizotinib. |
Dactinomycin | Dactinomycin The serum concentration of Crizotinib can be increased when it is combined with Dactinomycin. |
Carbamazepine | Carbamazepine The metabolism of Carbamazepine can be decreased when combined with Crizotinib. |
Methyldopa | Methyldopa Methyldopa may increase the bradycardic activities of Crizotinib. |
Clonidine | Clonidine The metabolism of Clonidine can be decreased when combined with Crizotinib. |
Prazosin | Prazosin The serum concentration of Prazosin can be increased when it is combined with Crizotinib. |
Hydralazine | Hydralazine The metabolism of Crizotinib can be decreased when combined with Hydralazine. |
Cimetidine | Cimetidine The metabolism of Cimetidine can be decreased when combined with Crizotinib. |
Warfarin | Warfarin The metabolism of Warfarin can be decreased when combined with Crizotinib. |
Loperamide | Loperamide The metabolism of Crizotinib can be decreased when combined with Loperamide. |
Promethazine | Promethazine The risk or severity of QTc prolongation can be increased when Promethazine is combined with Crizotinib. |
Daunorubicin | Daunorubicin The metabolism of Crizotinib can be decreased when combined with Daunorubicin. |
Griseofulvin | Griseofulvin The metabolism of Crizotinib can be increased when combined with Griseofulvin. |
Digoxin | Digoxin Crizotinib may decrease the excretion rate of Digoxin which could result in a higher serum level. |
Loxapine | Loxapine The serum concentration of Crizotinib can be increased when it is combined with Loxapine. |
Chloroquine | Chloroquine The metabolism of Chloroquine can be decreased when combined with Crizotinib. |
Quinine | Quinine The serum concentration of Quinine can be increased when it is combined with Crizotinib. |
Ethosuximide | Ethosuximide The risk or severity of QTc prolongation can be increased when Ethosuximide is combined with Crizotinib. |
Calcitriol | Calcitriol The metabolism of Crizotinib can be increased when combined with Calcitriol. |
Sulfinpyrazone | Sulfinpyrazone The metabolism of Crizotinib can be increased when combined with Sulfinpyrazone. |
Clindamycin Injection | Clindamycin Injection The metabolism of Clindamycin can be decreased when combined with Crizotinib. |
Secobarbital | Secobarbital The metabolism of Crizotinib can be increased when combined with Secobarbital. |
Desipramine | Desipramine The metabolism of Crizotinib can be decreased when combined with Desipramine. |
Amitriptyline | Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Crizotinib. |
Imipramine | Imipramine The serum concentration of Imipramine can be increased when it is combined with Crizotinib. |
Probenecid | Probenecid The metabolism of Crizotinib can be increased when combined with Probenecid. |
Quinidine | Quinidine The metabolism of Quinidine can be decreased when combined with Crizotinib. |
Procainamide | Procainamide The risk or severity of QTc prolongation can be increased when Crizotinib is combined with Procainamide. |
Isoniazid | Isoniazid The metabolism of Crizotinib can be decreased when combined with Isoniazid. |
Rifampin | Rifampin The metabolism of Crizotinib can be increased when combined with Rifampicin. |
Disopyramide | Disopyramide The risk or severity of QTc prolongation can be increased when Crizotinib is combined with Disopyramide. |
Valproic Acid | Valproic Acid The metabolism of Valproic acid can be decreased when combined with Crizotinib. |
Tamoxifen | Tamoxifen The metabolism of Crizotinib can be decreased when combined with Tamoxifen. |
Levothyroxine | Levothyroxine The therapeutic efficacy of Crizotinib can be decreased when used in combination with Levothyroxine. |
Liothyronine | Liothyronine The therapeutic efficacy of Liothyronine can be decreased when used in combination with Crizotinib. |
Methimazole | Methimazole The therapeutic efficacy of Methimazole can be decreased when used in combination with Crizotinib. |
Propylthiouracil | Propylthiouracil The therapeutic efficacy of Propylthiouracil can be decreased when used in combination with Crizotinib. |
Dextromethorphan | Dextromethorphan The metabolism of Dextromethorphan can be decreased when combined with Crizotinib. |
Niacin | Niacin The metabolism of Crizotinib can be decreased when combined with Niacin. |
Doxylamine | Doxylamine The risk or severity of QTc prolongation can be increased when Doxylamine is combined with Crizotinib. |
Cyproheptadine | Cyproheptadine The risk or severity of QTc prolongation can be increased when Cyproheptadine is combined with Crizotinib. |
Clemastine | Clemastine The risk or severity of QTc prolongation can be increased when Crizotinib is combined with Clemastine. |
Chlorpheniramine | Chlorpheniramine The metabolism of Crizotinib can be decreased when combined with Chlorpheniramine. |
Brompheniramine | Brompheniramine The risk or severity of QTc prolongation can be increased when Dexbrompheniramine is combined with Crizotinib. |
Hydrochlorothiazide | Hydrochlorothiazide The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Crizotinib. |
Danazol | Danazol The metabolism of Crizotinib can be decreased when combined with Danazol. |
Disulfiram | Disulfiram The metabolism of Crizotinib can be decreased when combined with Disulfiram. |
Propranolol (Cardiovascular) | Propranolol (Cardiovascular) The metabolism of Propranolol can be decreased when combined with Crizotinib. |
Nortriptyline | Nortriptyline The metabolism of Nortriptyline can be decreased when combined with Crizotinib. |
Amphotericin B Injection | Amphotericin B Injection The metabolism of Crizotinib can be decreased when combined with Amphotericin B. |
Nadolol | Nadolol Nadolol may increase the bradycardic activities of Crizotinib. |
Oxytocin Injection | Oxytocin Injection The risk or severity of QTc prolongation can be increased when Oxytocin is combined with Crizotinib. |
Clomiphene | Clomiphene The serum concentration of Clomifene can be increased when it is combined with Crizotinib. |
Papaverine | Papaverine The risk or severity of QTc prolongation can be increased when Papaverine is combined with Crizotinib. |
Fluorouracil Injection | Fluorouracil Injection The risk or severity of QTc prolongation can be increased when Fluorouracil is combined with Crizotinib. |
Colchicine | Colchicine The metabolism of Colchicine can be decreased when combined with Crizotinib. |
Cephalexin | Cephalexin The metabolism of Cephalexin can be decreased when combined with Crizotinib. |
Acetazolamide | Acetazolamide The metabolism of Crizotinib can be decreased when combined with Acetazolamide. |
Calcitonin Salmon Injection | Calcitonin Salmon Injection The therapeutic efficacy of Salmon calcitonin can be decreased when used in combination with Crizotinib. |
Ketoconazole | Ketoconazole The serum concentration of Crizotinib can be increased when it is combined with Ketoconazole. |
Thiotepa Injection | Thiotepa Injection The metabolism of Thiotepa can be decreased when combined with Crizotinib. |
Vincristine Injection | Vincristine Injection The metabolism of Vincristine can be decreased when combined with Crizotinib. |
Vinblastine | Vinblastine The metabolism of Crizotinib can be decreased when combined with Vinblastine. |
Metoprolol | Metoprolol The metabolism of Metoprolol can be decreased when combined with Crizotinib. |
Hydroxyzine | Hydroxyzine The risk or severity of QTc prolongation can be increased when Hydroxyzine is combined with Crizotinib. |
Thiothixene | Thiothixene The risk or severity of QTc prolongation can be increased when Thiothixene is combined with Crizotinib. |
Alprazolam | Alprazolam The metabolism of Alprazolam can be decreased when combined with Crizotinib. |
Triazolam | Triazolam The metabolism of Triazolam can be decreased when combined with Crizotinib. |
Hyoscyamine | Hyoscyamine The risk or severity of QTc prolongation can be increased when Hyoscyamine is combined with Crizotinib. |
Diltiazem | Diltiazem The metabolism of Crizotinib can be decreased when combined with Diltiazem. |
Nifedipine | Nifedipine The metabolism of Nifedipine can be increased when combined with Crizotinib. |
Timolol | Timolol The risk or severity of QTc prolongation can be increased when Timolol is combined with Crizotinib. |
Verapamil | Verapamil The serum concentration of Crizotinib can be increased when it is combined with Verapamil. |
Atenolol | Atenolol Atenolol may increase the bradycardic activities of Crizotinib. |
Pindolol | Pindolol Pindolol may increase the bradycardic activities of Crizotinib. |
Cisplatin Injection | Cisplatin Injection The serum concentration of Cisplatin can be increased when it is combined with Crizotinib. |
Etoposide | Etoposide The metabolism of Crizotinib can be decreased when combined with Etoposide. |
Glyburide | Glyburide The metabolism of Glyburide can be decreased when combined with Crizotinib. |
Indapamide | Indapamide The risk or severity of QTc prolongation can be increased when Indapamide is combined with Crizotinib. |
Dicloxacillin | Dicloxacillin The metabolism of Crizotinib can be increased when combined with Dicloxacillin. |
Nafcillin Injection | Nafcillin Injection The metabolism of Crizotinib can be increased when combined with Nafcillin. |
Pentamidine Injection | Pentamidine Injection The metabolism of Crizotinib can be decreased when combined with Pentamidine. |
Labetalol | Labetalol Labetalol may increase the bradycardic activities of Crizotinib. |
Leuprolide Injection | Leuprolide Injection The risk or severity of QTc prolongation can be increased when Leuprolide is combined with Crizotinib. |
Pimozide | Pimozide The metabolism of Pimozide can be decreased when combined with Crizotinib. |
Amiodarone | Amiodarone The metabolism of Amiodarone can be decreased when combined with Crizotinib. |
Buspirone | Buspirone The metabolism of Buspirone can be decreased when combined with Crizotinib. |
Lovastatin | Lovastatin The metabolism of Lovastatin can be decreased when combined with Crizotinib. |
Ciprofloxacin | Ciprofloxacin The metabolism of Crizotinib can be decreased when combined with Ciprofloxacin. |
Fluoxetine | Fluoxetine The risk or severity of QTc prolongation can be increased when Crizotinib is combined with Fluoxetine. |
Nimodipine | Nimodipine The risk or severity of QTc prolongation can be increased when Nimodipine is combined with Crizotinib. |
Clozapine | Clozapine The metabolism of Crizotinib can be increased when combined with Clozapine. |
Ofloxacin | Ofloxacin The risk or severity of QTc prolongation can be increased when Ofloxacin is combined with Crizotinib. |
Clarithromycin | Clarithromycin The serum concentration of Crizotinib can be increased when it is combined with Clarithromycin. |
Felodipine | Felodipine The metabolism of Felodipine can be decreased when combined with Crizotinib. |
Pravastatin | Pravastatin The serum concentration of Pravastatin can be increased when it is combined with Crizotinib. |
Simvastatin | Simvastatin The serum concentration of Simvastatin can be increased when it is combined with Crizotinib. |
Epoetin Alfa, Injection | Epoetin Alfa, Injection The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Crizotinib. |
Amlodipine | Amlodipine Amlodipine may increase the bradycardic activities of Crizotinib. |
Teniposide Injection | Teniposide Injection The metabolism of Teniposide can be decreased when combined with Crizotinib. |
Itraconazole | Itraconazole The serum concentration of Crizotinib can be increased when it is combined with Itraconazole. |
Rifabutin | Rifabutin The metabolism of Crizotinib can be increased when combined with Rifabutin. |
Sotalol | Sotalol The risk or severity of QTc prolongation can be increased when Crizotinib is combined with Sotalol. |
Bisoprolol | Bisoprolol The serum concentration of Crizotinib can be increased when it is combined with Bisoprolol. |
Doxazosin | Doxazosin The metabolism of Doxazosin can be decreased when combined with Crizotinib. |
Isradipine | Isradipine The metabolism of Crizotinib can be decreased when combined with Isradipine. |
Omeprazole | Omeprazole The metabolism of Crizotinib can be increased when combined with Omeprazole. |
Cisapride | Cisapride The metabolism of Crizotinib can be decreased when combined with Cisapride. |
Fluvastatin | Fluvastatin The metabolism of Fluvastatin can be decreased when combined with Crizotinib. |
Venlafaxine | Venlafaxine The risk or severity of QTc prolongation can be increased when Venlafaxine is combined with Crizotinib. |
Famciclovir | Famciclovir The metabolism of Famciclovir can be decreased when combined with Crizotinib. |
Fluvoxamine | Fluvoxamine The metabolism of Crizotinib can be decreased when combined with Fluvoxamine. |
Nefazodone | Nefazodone The metabolism of Crizotinib can be decreased when combined with Nefazodone. |
Lamotrigine | Lamotrigine The risk or severity of QTc prolongation can be increased when Lamotrigine is combined with Crizotinib. |
Losartan | Losartan The metabolism of Crizotinib can be decreased when combined with Losartan. |
Tramadol | Tramadol The metabolism of Tramadol can be decreased when combined with Crizotinib. |
Vinorelbine Injection | Vinorelbine Injection The metabolism of Vinorelbine can be decreased when combined with Crizotinib. |
Moexipril | Moexipril The risk or severity of QTc prolongation can be increased when Moexipril is combined with Crizotinib. |
Lansoprazole | Lansoprazole The metabolism of Crizotinib can be increased when combined with Lansoprazole. |
Ifosfamide Injection | Ifosfamide Injection The metabolism of Ifosfamide can be decreased when combined with Crizotinib. |
Nicardipine | Nicardipine The metabolism of Crizotinib can be decreased when combined with Nicardipine. |
Ticlopidine | Ticlopidine The metabolism of Ticlopidine can be decreased when combined with Crizotinib. |
Saquinavir | Saquinavir The serum concentration of Crizotinib can be increased when it is combined with Saquinavir. |
Metformin | Metformin The serum concentration of Metformin can be increased when it is combined with Crizotinib. |
Nisoldipine | Nisoldipine The metabolism of Nisoldipine can be decreased when combined with Crizotinib. |
Lamivudine | Lamivudine The serum concentration of Lamivudine can be increased when it is combined with Crizotinib. |
Gemcitabine Injection | Gemcitabine Injection The serum concentration of Gemcitabine can be increased when it is combined with Crizotinib. |
Indinavir | Indinavir The metabolism of Indinavir can be decreased when combined with Crizotinib. |
Ritonavir | Ritonavir The serum concentration of Crizotinib can be increased when it is combined with Ritonavir. |
Docetaxel Injection | Docetaxel Injection The metabolism of Docetaxel can be decreased when combined with Crizotinib. |
Clomipramine | Clomipramine The metabolism of Crizotinib can be decreased when combined with Clomipramine. |
Zafirlukast | Zafirlukast The metabolism of Crizotinib can be decreased when combined with Zafirlukast. |
Mirtazapine | Mirtazapine The metabolism of Crizotinib can be decreased when combined with Mirtazapine. |
Topiramate | Topiramate The metabolism of Crizotinib can be increased when combined with Topiramate. |
Pramipexole | Pramipexole The serum concentration of Pramipexole can be increased when it is combined with Crizotinib. |
Donepezil | Donepezil Donepezil may increase the bradycardic activities of Crizotinib. |
Nelfinavir | Nelfinavir The metabolism of Crizotinib can be decreased when combined with Nelfinavir. |
Fexofenadine | Fexofenadine The serum concentration of Crizotinib can be increased when it is combined with Fexofenadine. |
Azithromycin | Azithromycin The metabolism of Azithromycin can be decreased when combined with Crizotinib. |
Carvedilol | Carvedilol The serum concentration of Crizotinib can be increased when it is combined with Carvedilol. |
Flutamide | Flutamide The metabolism of Flutamide can be decreased when combined with Crizotinib. |
Bicalutamide | Bicalutamide The metabolism of Crizotinib can be decreased when combined with Bicalutamide. |
Propafenone | Propafenone The serum concentration of Crizotinib can be increased when it is combined with Propafenone. |
Raloxifene | Raloxifene The metabolism of Crizotinib can be decreased when combined with Raloxifene. |
Irbesartan | Irbesartan The metabolism of Crizotinib can be decreased when combined with Irbesartan. |
Finasteride | Finasteride The metabolism of Finasteride can be decreased when combined with Crizotinib. |
Quetiapine | Quetiapine The metabolism of Quetiapine can be decreased when combined with Crizotinib. |
Cetirizine | Cetirizine The risk or severity of QTc prolongation can be increased when Cetirizine is combined with Crizotinib. |
Paroxetine | Paroxetine The metabolism of Crizotinib can be decreased when combined with Paroxetine. |
Citalopram | Citalopram The metabolism of Citalopram can be decreased when combined with Crizotinib. |
Efavirenz | Efavirenz The metabolism of Crizotinib can be increased when combined with Efavirenz. |
Sildenafil | Sildenafil The serum concentration of Sildenafil can be increased when it is combined with Crizotinib. |
Tolterodine | Tolterodine The risk or severity of QTc prolongation can be increased when Tolterodine is combined with Crizotinib. |
Thalidomide | Thalidomide The metabolism of Crizotinib can be increased when combined with Thalidomide. |
Nateglinide | Nateglinide The metabolism of Nateglinide can be decreased when combined with Crizotinib. |
Galantamine | Galantamine The risk or severity of QTc prolongation can be increased when Galantamine is combined with Crizotinib. |
Rabeprazole | Rabeprazole The metabolism of Crizotinib can be decreased when combined with Rabeprazole. |
Terbinafine | Terbinafine The metabolism of Crizotinib can be increased when combined with Terbinafine. |
Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists