Crizotinib

Crizotinib is used to treat certain types of non-small cell lung cancer (NSCLC) that has spread to nearby tissues or to other parts of the body. It is also used to treat a certain type of anaplastic large cell lymphoma (ALCL) that has returned or is unresponsive to other treatment(s) in certain adults and children 1 year of age and older. Crizotinib is in a class of medications called kinase inhibitors. It works by blocking the action of a certain naturally occurring substance that may be needed to help cancer cells multiply.

Crizotinib comes as a capsule to take by mouth. It is usually taken with or without food twice a day. Take crizotinib at around the same times every day. Follow the directions on your prescription label carefully and ask your doctor or pharmacist to explain any part you do not understand. Take crizotinib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the capsules whole; do not split, chew, or crush them. Do not touch capsules that are broken or crushed.

Your doctor may temporarily or permanently stop your treatment, decrease the dose, or tell you take your medication less often if you experience serious side effects of crizotinib. Tell your doctor how you are feeling during your treatment.

Continue to take crizotinib even if you feel well. Do not stop taking crizotinib without talking to your doctor.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking crizotinib,

• tell your doctor and pharmacist if you are allergic to crizotinib, any other medications, or any of the ingredients in crizotinib capsules. Ask your pharmacist or check the manufacturer's patient information for a list of the ingredients.

• tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: amiodarone (Cordarone, Pacerone); certain antibiotics such as clarithromycin (Biaxin); certain antifungal medications such as itraconaozole (Sporanox), ketoconazole (Nizoral), and voriconazole (Vfend); certain blood pressure medications; chloroquine (Aralen); chlorpromazine (Thorazine); citalopram (Celexa); cyclosporine (Gengraf, Neoral, Sandimmune); digoxin (Lanoxin); dihydroergotamine (D.H.E. 45, Migranal); disopyramide (Norpace); dofetilide (Tikosyn); droperidol (Inapsine); ergotamine (Ergomar, in Cafergot, in Migergot); erythromycin (E.E.S., Erythrocin); fentanyl (Abstral, Actiq, Fentora, Lazanda, Onsolis); flecainide (Tambocor); certain medications for human immunodeficiency virus (HIV) such as atazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), and saquinavir (Invirase); certain medications for seizures such as carbamazepine (Carbatrol, Equetro, Tegretol), phenobarbital, and phenytoin (Dilantin); mesoridazine (Serentil); methadone (Dolophine); moxifloxacin (Avelox); nefazodone; pentamidine (NebuPent, Pentam); pimozide (Orap); procainamide (Pronestyl); quinidine (in Nuedexta); rifabutin (Mycobutin), rifampin (Rimactane, Rifadin, in Rifater); sirolimus (Rapamune); sotalol (Betapace); tacrolimus (Prograf); telithromycin (Ketek); thioridazine (Mellaril); and vandetanib (Caprelsa). Many other medications may also interact with crizotinib, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

• tell your doctor what herbal products you are taking, especially St. John's wort.

• tell your doctor if you have or have ever had long QT syndrome (a rare heart problem that may cause irregular heartbeat, fainting, or sudden death), a slow heartbeat, heart failure, vision problems, lung problems other than lung cancer, or liver or kidney disease.

• tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. You will need to have a pregnancy test before you start treatment with crizotinib. If you are female, you should use birth control during your treatment and for 45 days after your final dose. If you are male, you and your female partner should use birth control during your treatment and for 90 days after your final dose. Talk to your doctor about which method of birth control you should use. If you become pregnant while taking crizotinib, call your doctor immediately. Crizotinib may harm the fetus.

• tell your doctor if you are breastfeeding. Do not breastfeed during your treatment and for 45 days after your final dose.

• you should know that this medication may decrease fertility in men and women. Talk to your doctor about the risks of taking crizotinib.

• if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking crizotinib.

• you should know that crizotinib may cause vision problems, dizziness, and excessive tiredness. Do not drive a car or operate machinery until you know how this medication affects you.

Do not eat grapefruit or drink grapefruit juice while taking this medication.

Take the missed dose as soon as you remember it. However, if it is less than 6 hours before you are scheduled to take your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

• Crizotinib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • diarrhea

  • constipation

  • stomach pain

  • sores in the mouth

  • change in ability to taste food

  • heartburn

  • headache

  • numbness, burning, or tingling in the hands or feet

  • difficulty falling asleep or staying asleep

• Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

  • shortness of breath

  • cough

  • fever

  • swelling of the arms, hands, feet, ankles, or lower legs

  • chest pain

  • slow heartbeat

  • rash

  • weakness

  • excessive tiredness

  • pain in the right upper part of the stomach

  • nausea

  • vomiting

  • difficulty swallowing

  • yellowing of the skin or eyes

  • dark urine

  • itching

  • fever

  • unusual bleeding or bruising

  • double or blurred vision

  • changes in vision

  • sensitivity to light

  • seeing sudden flashes of light

  • seeing new or increased floaters (spots in your vision)

• Crizotinib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

• If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor and the laboratory. Your doctor will order a lab test before you begin your treatment to see whether your cancer can be treated with crizotinib and will also order certain lab tests during your treatment to check your body's response to crizotinib. Your doctor will also check your heart rate and blood pressure regularly during your treatment.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug	Interaction
Moxifloxacin	Moxifloxacin The risk or severity of QTc prolongation can be increased when Moxifloxacin is combined with Crizotinib.
Delavirdine	Delavirdine The metabolism of Crizotinib can be decreased when combined with Delavirdine.
Nevirapine	Nevirapine The metabolism of Nevirapine can be decreased when combined with Crizotinib.
Atorvastatin	Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Crizotinib.
Dolasetron	Dolasetron The risk or severity of QTc prolongation can be increased when Dolasetron is combined with Crizotinib.
Aminophylline	Aminophylline The metabolism of Aminophylline can be decreased when combined with Crizotinib.
Anagrelide	Anagrelide The risk or severity of QTc prolongation can be increased when Crizotinib is combined with Anagrelide.
Cilostazol	Cilostazol The metabolism of Cilostazol can be decreased when combined with Crizotinib.
Clopidogrel	Clopidogrel The metabolism of Clopidogrel can be decreased when combined with Crizotinib.
Erythromycin and Sulfisoxazole	Erythromycin and Sulfisoxazole The serum concentration of Crizotinib can be increased when it is combined with Erythromycin.
Fenofibrate	Fenofibrate The metabolism of Fenofibrate can be decreased when combined with Crizotinib.
Guanfacine	Guanfacine Guanfacine may increase the bradycardic activities of Crizotinib.
Methylergonovine	Methylergonovine The metabolism of Crizotinib can be decreased when combined with Methylergometrine.
Paregoric	Paregoric The serum concentration of Morphine can be increased when it is combined with Crizotinib.
Penbutolol	Penbutolol The risk or severity of QTc prolongation can be increased when Acebutolol is combined with Crizotinib.
Ranitidine	Ranitidine The serum concentration of Ranitidine can be increased when it is combined with Crizotinib.
Reserpine	Reserpine The serum concentration of Crizotinib can be increased when it is combined with Reserpine.
Tacrolimus	Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Crizotinib.
Tizanidine	Tizanidine The risk or severity of QTc prolongation can be increased when Tizanidine is combined with Crizotinib.
Triamcinolone	Triamcinolone The metabolism of Triamcinolone can be increased when combined with Crizotinib.
Doxycycline Injection	Doxycycline Injection The metabolism of Crizotinib can be decreased when combined with Doxycycline.
Famotidine Injection	Famotidine Injection The risk or severity of QTc prolongation can be increased when Famotidine is combined with Crizotinib.
Fluconazole Injection	Fluconazole Injection The serum concentration of Crizotinib can be increased when it is combined with Fluconazole.
Foscarnet Injection	Foscarnet Injection The risk or severity of QTc prolongation can be increased when Foscarnet is combined with Crizotinib.
Levofloxacin Injection	Levofloxacin Injection The risk or severity of QTc prolongation can be increased when Levofloxacin is combined with Crizotinib.
Meperidine Injection	Meperidine Injection The metabolism of Meperidine can be increased when combined with Crizotinib.
Methylprednisolone Injection	Methylprednisolone Injection The metabolism of Crizotinib can be increased when combined with Methylprednisolone.
Metoclopramide Injection	Metoclopramide Injection The risk or severity of QTc prolongation can be increased when Metoclopramide is combined with Crizotinib.
Metronidazole Injection	Metronidazole Injection The metabolism of Metronidazole can be decreased when combined with Crizotinib.
Morphine Injection	Morphine Injection The serum concentration of Morphine can be increased when it is combined with Crizotinib.
Cyclosporine	Cyclosporine The serum concentration of Cyclosporine can be increased when it is combined with Crizotinib.
Ondansetron	Ondansetron The metabolism of Ondansetron can be decreased when combined with Crizotinib.
Granisetron	Granisetron The risk or severity of QTc prolongation can be increased when Granisetron is combined with Crizotinib.
Olanzapine	Olanzapine The risk or severity of QTc prolongation can be increased when Olanzapine is combined with Crizotinib.
Dofetilide	Dofetilide The metabolism of Dofetilide can be decreased when combined with Crizotinib.
Hydroxychloroquine	Hydroxychloroquine The risk or severity of QTc prolongation can be increased when Hydroxychloroquine is combined with Crizotinib.
Orlistat	Orlistat The metabolism of Crizotinib can be increased when combined with Orlistat.
Oxcarbazepine	Oxcarbazepine The metabolism of Crizotinib can be increased when combined with Oxcarbazepine.
Zaleplon	Zaleplon The metabolism of Zaleplon can be decreased when combined with Crizotinib.
Anakinra	Anakinra The metabolism of Crizotinib can be increased when combined with Anakinra.
Desloratadine	Desloratadine The risk or severity of QTc prolongation can be increased when Desloratadine is combined with Crizotinib.
Rivastigmine	Rivastigmine Rivastigmine may increase the bradycardic activities of Crizotinib.
Trimipramine	Trimipramine The serum concentration of Crizotinib can be increased when it is combined with Trimipramine.
Etanercept Injection	Etanercept Injection The metabolism of Crizotinib can be increased when combined with Etanercept.
Modafinil	Modafinil The metabolism of Crizotinib can be increased when combined with Modafinil.
Tenofovir	Tenofovir The metabolism of Tenofovir can be decreased when combined with Crizotinib.
Sirolimus	Sirolimus The metabolism of Sirolimus can be decreased when combined with Crizotinib.
Dutasteride	Dutasteride The metabolism of Dutasteride can be decreased when combined with Crizotinib.
Epinephrine Injection	Epinephrine Injection The metabolism of Epinephrine can be decreased when combined with Crizotinib.
Eplerenone	Eplerenone The metabolism of Eplerenone can be decreased when combined with Crizotinib.
Escitalopram	Escitalopram The risk or severity of QTc prolongation can be increased when Crizotinib is combined with Escitalopram.
Zonisamide	Zonisamide The serum concentration of Crizotinib can be increased when it is combined with Zonisamide.
Adalimumab Injection	Adalimumab Injection The metabolism of Crizotinib can be increased when combined with Adalimumab.
Aripiprazole	Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Crizotinib.
Atomoxetine	Atomoxetine The risk or severity of QTc prolongation can be increased when Atomoxetine is combined with Crizotinib.
Teriparatide Injection	Teriparatide Injection The therapeutic efficacy of Teriparatide can be decreased when used in combination with Crizotinib.
Atazanavir	Atazanavir The metabolism of Crizotinib can be decreased when combined with Atazanavir.
Mefloquine	Mefloquine The metabolism of Crizotinib can be decreased when combined with Mefloquine.
Rosuvastatin	Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Crizotinib.
Vardenafil	Vardenafil The metabolism of Vardenafil can be decreased when combined with Crizotinib.
Alfuzosin	Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Crizotinib.
Aprepitant	Aprepitant The metabolism of Crizotinib can be decreased when combined with Aprepitant.
Memantine	Memantine The serum concentration of Memantine can be increased when it is combined with Crizotinib.
Tegaserod	Tegaserod The serum concentration of Tegaserod can be increased when it is combined with Crizotinib.
Tadalafil	Tadalafil The metabolism of Tadalafil can be decreased when combined with Crizotinib.
Gemifloxacin	Gemifloxacin The risk or severity of QTc prolongation can be increased when Gemifloxacin is combined with Crizotinib.
Progesterone	Progesterone The metabolism of Progesterone can be increased when combined with Crizotinib.
Apomorphine Injection	Apomorphine Injection The metabolism of Crizotinib can be decreased when combined with Apomorphine.
Darbepoetin Alfa Injection	Darbepoetin Alfa Injection The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Crizotinib.
Infliximab Injection	Infliximab Injection The metabolism of Crizotinib can be increased when combined with Infliximab.
Protriptyline	Protriptyline The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Crizotinib.
Rifaximin	Rifaximin The serum concentration of Rifaximin can be increased when it is combined with Crizotinib.
Duloxetine	Duloxetine The metabolism of Duloxetine can be decreased when combined with Crizotinib.
Norethindrone	Norethindrone The metabolism of Norethisterone can be decreased when combined with Crizotinib.
Bosentan	Bosentan The metabolism of Crizotinib can be increased when combined with Bosentan.
Erlotinib	Erlotinib The metabolism of Erlotinib can be decreased when combined with Crizotinib.
Eszopiclone	Eszopiclone The metabolism of Eszopiclone can be decreased when combined with Crizotinib.
Solifenacin	Solifenacin The risk or severity of QTc prolongation can be increased when Solifenacin is combined with Crizotinib.
Voriconazole	Voriconazole The metabolism of Crizotinib can be decreased when combined with Voriconazole.
Ibandronate	Ibandronate The risk or severity of QTc prolongation can be increased when Ibandronate is combined with Crizotinib.
Fentanyl	Fentanyl The metabolism of Fentanyl can be decreased when combined with Crizotinib.
Pregabalin	Pregabalin The risk or severity of QTc prolongation can be increased when Pregabalin is combined with Crizotinib.
Deferasirox	Deferasirox The metabolism of Crizotinib can be increased when combined with Deferasirox.
Tipranavir	Tipranavir The serum concentration of Crizotinib can be increased when it is combined with Tipranavir.
Felbamate	Felbamate The metabolism of Crizotinib can be increased when combined with Felbamate.
Ranolazine	Ranolazine The serum concentration of Crizotinib can be increased when it is combined with Ranolazine.
Abatacept Injection	Abatacept Injection The metabolism of Crizotinib can be increased when combined with Abatacept.
Imatinib	Imatinib The metabolism of Crizotinib can be decreased when combined with Imatinib.
Sitagliptin	Sitagliptin The serum concentration of Sitagliptin can be increased when it is combined with Crizotinib.
Varenicline	Varenicline The excretion of Varenicline can be decreased when combined with Crizotinib.
Gefitinib	Gefitinib The metabolism of Gefitinib can be decreased when combined with Crizotinib.
Albuterol	Albuterol The risk or severity of QTc prolongation can be increased when Salbutamol is combined with Crizotinib.
Paliperidone	Paliperidone The serum concentration of Paliperidone can be increased when it is combined with Crizotinib.
Bortezomib	Bortezomib The metabolism of Crizotinib can be decreased when combined with Bortezomib.
Clofarabine Injection	Clofarabine Injection The serum concentration of Clofarabine can be increased when it is combined with Crizotinib.
Oxaliplatin Injection	Oxaliplatin Injection The serum concentration of Oxaliplatin can be increased when it is combined with Crizotinib.
Posaconazole	Posaconazole The metabolism of Crizotinib can be decreased when combined with Posaconazole.
Primaquine	Primaquine The metabolism of Crizotinib can be decreased when combined with Primaquine.
Darunavir	Darunavir The serum concentration of Crizotinib can be increased when it is combined with Darunavir.
Dimenhydrinate	Dimenhydrinate The risk or severity of QTc prolongation can be increased when Dimenhydrinate is combined with Crizotinib.
Retapamulin	Retapamulin The metabolism of Retapamulin can be decreased when combined with Crizotinib.
Vorinostat	Vorinostat The risk or severity of QTc prolongation can be increased when Vorinostat is combined with Crizotinib.
Sorafenib	Sorafenib The metabolism of Crizotinib can be decreased when combined with Sorafenib.
Sunitinib	Sunitinib The metabolism of Sunitinib can be decreased when combined with Crizotinib.
Lapatinib	Lapatinib The serum concentration of Crizotinib can be increased when it is combined with Lapatinib.
Levocetirizine	Levocetirizine The risk or severity of QTc prolongation can be increased when Levocetirizine is combined with Crizotinib.
Dasatinib	Dasatinib The metabolism of Dasatinib can be decreased when combined with Crizotinib.
Armodafinil	Armodafinil The metabolism of Crizotinib can be increased when combined with Armodafinil.
Ivermectin	Ivermectin The metabolism of Crizotinib can be increased when combined with Ivermectin.
Temsirolimus	Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Crizotinib.
Nilotinib	Nilotinib The metabolism of Nilotinib can be decreased when combined with Crizotinib.
Toremifene	Toremifene The serum concentration of Toremifene can be increased when it is combined with Crizotinib.
Bexarotene	Bexarotene The metabolism of Crizotinib can be increased when combined with Bexarotene.
Budesonide	Budesonide The metabolism of Crizotinib can be increased when combined with Budesonide.
Chloramphenicol Injection	Chloramphenicol Injection The metabolism of Crizotinib can be decreased when combined with Chloramphenicol.
Etravirine	Etravirine The metabolism of Crizotinib can be increased when combined with Etravirine.
Arsenic Trioxide Injection	Arsenic Trioxide Injection The risk or severity of QTc prolongation can be increased when Crizotinib is combined with Arsenic trioxide.
Mitoxantrone Injection	Mitoxantrone Injection The metabolism of Crizotinib can be decreased when combined with Mitoxantrone.
Desvenlafaxine	Desvenlafaxine The metabolism of Crizotinib can be decreased when combined with Desvenlafaxine.
Nebivolol	Nebivolol Nebivolol may increase the bradycardic activities of Crizotinib.
Tretinoin	Tretinoin The metabolism of Tretinoin can be decreased when combined with Crizotinib.
Bendamustine Injection	Bendamustine Injection The serum concentration of Bendamustine can be increased when it is combined with Crizotinib.
Pilocarpine	Pilocarpine The metabolism of Crizotinib can be decreased when combined with Pilocarpine.
Flecainide	Flecainide The risk or severity of QTc prolongation can be increased when Flecainide is combined with Crizotinib.
Certolizumab Injection	Certolizumab Injection The metabolism of Crizotinib can be increased when combined with Certolizumab pegol.
Ixabepilone Injection	Ixabepilone Injection The metabolism of Ixabepilone can be decreased when combined with Crizotinib.
Irinotecan Injection	Irinotecan Injection The metabolism of Irinotecan can be decreased when combined with Crizotinib.
Praziquantel	Praziquantel The metabolism of Praziquantel can be decreased when combined with Crizotinib.
Mitotane	Mitotane The metabolism of Crizotinib can be increased when combined with Mitotane.
Rufinamide	Rufinamide The metabolism of Rufinamide can be increased when combined with Crizotinib.
Silodosin	Silodosin The serum concentration of Silodosin can be increased when it is combined with Crizotinib.
Midazolam	Midazolam The serum concentration of Midazolam can be increased when it is combined with Crizotinib.
Milnacipran	Milnacipran The metabolism of Crizotinib can be decreased when combined with Milnacipran.
Degarelix Injection	Degarelix Injection The risk or severity of QTc prolongation can be increased when Degarelix is combined with Crizotinib.
Betaxolol	Betaxolol The risk or severity of QTc prolongation can be increased when Betaxolol is combined with Crizotinib.
Iloperidone	Iloperidone The metabolism of Iloperidone can be decreased when combined with Crizotinib.
Lacosamide	Lacosamide The metabolism of Lacosamide can be decreased when combined with Crizotinib.
Everolimus	Everolimus The metabolism of Everolimus can be decreased when combined with Crizotinib.
Tolvaptan (low blood sodium)	Tolvaptan (low blood sodium) The metabolism of Tolvaptan can be decreased when combined with Crizotinib.
Dronedarone	Dronedarone The metabolism of Dronedarone can be decreased when combined with Crizotinib.
Saxagliptin	Saxagliptin The metabolism of Saxagliptin can be decreased when combined with Crizotinib.
Telavancin Injection	Telavancin Injection The risk or severity of QTc prolongation can be increased when Telavancin is combined with Crizotinib.
Romidepsin Injection	Romidepsin Injection The metabolism of Romidepsin can be decreased when combined with Crizotinib.
Topotecan	Topotecan The serum concentration of Topotecan can be increased when it is combined with Crizotinib.
Golimumab Injection	Golimumab Injection The metabolism of Crizotinib can be increased when combined with Golimumab.
Pazopanib	Pazopanib The serum concentration of Pazopanib can be increased when it is combined with Crizotinib.
Asenapine	Asenapine The risk or severity of QTc prolongation can be increased when Crizotinib is combined with Asenapine.
Albendazole	Albendazole The metabolism of Albendazole can be decreased when combined with Crizotinib.
Levonorgestrel	Levonorgestrel The metabolism of Levonorgestrel can be decreased when combined with Crizotinib.
Tocilizumab Injection	Tocilizumab Injection The metabolism of Crizotinib can be increased when combined with Tocilizumab.
Dalfampridine	Dalfampridine The serum concentration of Dalfampridine can be increased when it is combined with Crizotinib.
Fingolimod	Fingolimod Crizotinib may increase the bradycardic activities of Fingolimod.
Eribulin Injection	Eribulin Injection The risk or severity of QTc prolongation can be increased when Eribulin is combined with Crizotinib.
Cabazitaxel Injection	Cabazitaxel Injection The metabolism of Crizotinib can be decreased when combined with Cabazitaxel.
Lurasidone	Lurasidone The metabolism of Lurasidone can be decreased when combined with Crizotinib.
Acetaminophen Injection	Acetaminophen Injection The metabolism of Acetaminophen can be increased when combined with Crizotinib.
Denileukin Diftitox Injection	Denileukin Diftitox Injection The metabolism of Crizotinib can be decreased when combined with Aldesleukin.
Terbutaline Injection	Terbutaline Injection The risk or severity of QTc prolongation can be increased when Terbutaline is combined with Crizotinib.
Busulfan Injection	Busulfan Injection The metabolism of Busulfan can be decreased when combined with Crizotinib.
Roflumilast	Roflumilast The metabolism of Roflumilast can be decreased when combined with Crizotinib.
Linagliptin	Linagliptin The serum concentration of Linagliptin can be increased when it is combined with Crizotinib.
Rilpivirine	Rilpivirine The metabolism of Crizotinib can be decreased when combined with Rilpivirine.
Telaprevir	Telaprevir The serum concentration of Glecaprevir can be increased when it is combined with Crizotinib.
Potassium Iodide	Potassium Iodide The therapeutic efficacy of Potassium Iodide can be decreased when used in combination with Crizotinib.
Cyclophosphamide Injection	Cyclophosphamide Injection The metabolism of Cyclophosphamide can be decreased when combined with Crizotinib.
Triptorelin Injection	Triptorelin Injection The risk or severity of QTc prolongation can be increased when Triptorelin is combined with Crizotinib.
Rivaroxaban	Rivaroxaban The metabolism of Rivaroxaban can be decreased when combined with Crizotinib.
Ticagrelor	Ticagrelor The serum concentration of Crizotinib can be increased when it is combined with Ticagrelor.
Brentuximab Vedotin Injection	Brentuximab Vedotin Injection The metabolism of Brentuximab vedotin can be decreased when combined with Crizotinib.
Ruxolitinib	Ruxolitinib The metabolism of Crizotinib can be decreased when combined with Ruxolitinib.
Vandetanib	Vandetanib The metabolism of Vandetanib can be decreased when combined with Crizotinib.
Clobazam	Clobazam The metabolism of Clobazam can be increased when combined with Crizotinib.
Vemurafenib	Vemurafenib The serum concentration of Crizotinib can be increased when it is combined with Vemurafenib.
Ivacaftor	Ivacaftor The metabolism of Crizotinib can be decreased when combined with Ivacaftor.
Axitinib	Axitinib The metabolism of Axitinib can be decreased when combined with Crizotinib.
Cabergoline	Cabergoline The metabolism of Cabergoline can be decreased when combined with Crizotinib.
Naloxone Injection	Naloxone Injection The metabolism of Crizotinib can be decreased when combined with Naloxone.
Ambrisentan	Ambrisentan The metabolism of Ambrisentan can be decreased when combined with Crizotinib.
Carfilzomib Injection	Carfilzomib Injection The serum concentration of Carfilzomib can be increased when it is combined with Crizotinib.
Enzalutamide	Enzalutamide The serum concentration of Crizotinib can be increased when it is combined with Enzalutamide.
Mirabegron	Mirabegron The serum concentration of Mirabegron can be increased when it is combined with Crizotinib.
Regorafenib	Regorafenib The metabolism of Regorafenib can be decreased when combined with Crizotinib.
Bosutinib	Bosutinib The serum concentration of Bosutinib can be increased when it is combined with Crizotinib.
Corticotropin, Repository Injection	Corticotropin, Repository Injection The metabolism of Crizotinib can be increased when combined with Corticotropin.
Bedaquiline	Bedaquiline The risk or severity of QTc prolongation can be increased when Crizotinib is combined with Bedaquiline.
Tofacitinib	Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Crizotinib.
Ponatinib	Ponatinib The metabolism of Ponatinib can be decreased when combined with Crizotinib.
Pomalidomide	Pomalidomide The metabolism of Pomalidomide can be decreased when combined with Crizotinib.
Ado-trastuzumab Emtansine Injection	Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be decreased when combined with Crizotinib.
Apixaban	Apixaban The metabolism of Apixaban can be decreased when combined with Crizotinib.
Canagliflozin	Canagliflozin The serum concentration of Canagliflozin can be increased when it is combined with Crizotinib.
Dabrafenib	Dabrafenib The metabolism of Dabrafenib can be decreased when combined with Crizotinib.
Trametinib	Trametinib The metabolism of Crizotinib can be increased when combined with Trametinib.
Dolutegravir	Dolutegravir The serum concentration of Dolutegravir can be increased when it is combined with Crizotinib.
Afatinib	Afatinib The serum concentration of Afatinib can be increased when it is combined with Crizotinib.
Vortioxetine	Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Crizotinib.
Perampanel	Perampanel The metabolism of Perampanel can be increased when combined with Crizotinib.
Ibrutinib	Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Crizotinib.
Lomitapide	Lomitapide The metabolism of Lomitapide can be decreased when combined with Crizotinib.
Avanafil	Avanafil The metabolism of Avanafil can be decreased when combined with Crizotinib.
Simeprevir	Simeprevir The serum concentration of Crizotinib can be increased when it is combined with Simeprevir.
Sofosbuvir	Sofosbuvir The serum concentration of Sofosbuvir can be increased when it is combined with Crizotinib.
Apremilast	Apremilast The metabolism of Crizotinib can be increased when combined with Apremilast.
Ceritinib	Ceritinib Crizotinib may increase the bradycardic activities of Ceritinib.
Siltuximab Injection	Siltuximab Injection The metabolism of Crizotinib can be increased when combined with Siltuximab.
Eslicarbazepine	Eslicarbazepine The metabolism of Crizotinib can be increased when combined with Eslicarbazepine.
Belinostat Injection	Belinostat Injection The serum concentration of Belinostat can be increased when it is combined with Crizotinib.
Idelalisib	Idelalisib The metabolism of Crizotinib can be decreased when combined with Idelalisib.
Testosterone Injection	Testosterone Injection The metabolism of Testosterone can be increased when combined with Crizotinib.
Oritavancin Injection	Oritavancin Injection The metabolism of Crizotinib can be increased when combined with Oritavancin.
Vorapaxar	Vorapaxar The serum concentration of Crizotinib can be increased when it is combined with Vorapaxar.
Suvorexant	Suvorexant The serum concentration of Crizotinib can be increased when it is combined with Suvorexant.
Edoxaban	Edoxaban The serum concentration of Edoxaban can be increased when it is combined with Crizotinib.
Olaparib	Olaparib The metabolism of Olaparib can be decreased when combined with Crizotinib.
Tasimelteon	Tasimelteon The metabolism of Tasimelteon can be decreased when combined with Crizotinib.
Lanreotide Injection	Lanreotide Injection The metabolism of Crizotinib can be decreased when combined with Lanreotide.
Nintedanib	Nintedanib The metabolism of Nintedanib can be decreased when combined with Crizotinib.
Secukinumab Injection	Secukinumab Injection The metabolism of Crizotinib can be increased when combined with Secukinumab.
Risperidone Injection	Risperidone Injection The metabolism of Risperidone can be decreased when combined with Crizotinib.
Palbociclib	Palbociclib The metabolism of Palbociclib can be decreased when combined with Crizotinib.
Lenvatinib	Lenvatinib The metabolism of Lenvatinib can be increased when combined with Crizotinib.
Naloxegol	Naloxegol The serum concentration of Naloxegol can be increased when it is combined with Crizotinib.
Panobinostat	Panobinostat The metabolism of Panobinostat can be decreased when combined with Crizotinib.
Haloperidol Injection	Haloperidol Injection The risk or severity of QTc prolongation can be increased when Crizotinib is combined with Haloperidol.
Ivabradine	Ivabradine The metabolism of Ivabradine can be decreased when combined with Crizotinib.
Isavuconazonium Injection	Isavuconazonium Injection The serum concentration of Crizotinib can be increased when it is combined with Isavuconazonium.
Sonidegib	Sonidegib The metabolism of Sonidegib can be decreased when combined with Crizotinib.
Flibanserin	Flibanserin The metabolism of Crizotinib can be decreased when combined with Flibanserin.
Rolapitant	Rolapitant The serum concentration of Crizotinib can be increased when it is combined with Rolapitant.
Prednisolone	Prednisolone The metabolism of Crizotinib can be increased when combined with Prednisolone.
Daclatasvir	Daclatasvir The serum concentration of Crizotinib can be increased when it is combined with Daclatasvir.
Brexpiprazole	Brexpiprazole The metabolism of Brexpiprazole can be decreased when combined with Crizotinib.
Ziprasidone Injection	Ziprasidone Injection The risk or severity of QTc prolongation can be increased when Crizotinib is combined with Ziprasidone.
Cobimetinib	Cobimetinib The metabolism of Cobimetinib can be decreased when combined with Crizotinib.
Trabectedin Injection	Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Crizotinib.
Osimertinib	Osimertinib The metabolism of Osimertinib can be decreased when combined with Crizotinib.
Alectinib	Alectinib The metabolism of Alectinib can be decreased when combined with Crizotinib.
Ixazomib	Ixazomib The metabolism of Ixazomib can be decreased when combined with Crizotinib.
Rifapentine	Rifapentine The metabolism of Crizotinib can be increased when combined with Rifapentine.
Lesinurad	Lesinurad The metabolism of Crizotinib can be increased when combined with Lesinurad.
Amphotericin B Liposomal Injection	Amphotericin B Liposomal Injection The metabolism of Crizotinib can be decreased when combined with Amphotericin B.
Dexamethasone Injection	Dexamethasone Injection The metabolism of Dexamethasone can be increased when combined with Crizotinib.
Venetoclax	Venetoclax The metabolism of Venetoclax can be decreased when combined with Crizotinib.
Cobicistat	Cobicistat The serum concentration of Crizotinib can be increased when it is combined with Cobicistat.
Midodrine	Midodrine Midodrine may increase the bradycardic activities of Crizotinib.
Selexipag	Selexipag The serum concentration of Selexipag can be increased when it is combined with Crizotinib.
Diphenhydramine Injection	Diphenhydramine Injection The risk or severity of QTc prolongation can be increased when Diphenhydramine is combined with Crizotinib.
Rucaparib	Rucaparib The serum concentration of Rucaparib can be increased when it is combined with Crizotinib.
Ribociclib	Ribociclib The metabolism of Ribociclib can be decreased when combined with Crizotinib.
Parathyroid Hormone Injection	Parathyroid Hormone Injection The therapeutic efficacy of Parathyroid hormone can be decreased when used in combination with Crizotinib.
Brigatinib	Brigatinib The metabolism of Brigatinib can be decreased when combined with Crizotinib.
Doxepin (Insomnia)	Doxepin (Insomnia) The risk or severity of QTc prolongation can be increased when Doxepin is combined with Crizotinib.
Deutetrabenazine	Deutetrabenazine The metabolism of Deutetrabenazine can be decreased when combined with Crizotinib.
Valbenazine	Valbenazine The metabolism of Valbenazine can be decreased when combined with Crizotinib.
Deflazacort	Deflazacort The serum concentration of Crizotinib can be increased when it is combined with Deflazacort.
Safinamide	Safinamide The metabolism of Crizotinib can be decreased when combined with Safinamide.
Sarilumab Injection	Sarilumab Injection The metabolism of Crizotinib can be increased when combined with Sarilumab.
Midostaurin	Midostaurin The metabolism of Crizotinib can be decreased when combined with Midostaurin.
Neratinib	Neratinib The metabolism of Crizotinib can be decreased when combined with Neratinib.
Abaloparatide Injection	Abaloparatide Injection The therapeutic efficacy of Abaloparatide can be decreased when used in combination with Crizotinib.
Enasidenib	Enasidenib The metabolism of Crizotinib can be decreased when combined with Enasidenib.
Inotuzumab Ozogamicin Injection	Inotuzumab Ozogamicin Injection The serum concentration of Inotuzumab ozogamicin can be increased when it is combined with Crizotinib.
Aprepitant/Fosaprepitant Injection	Aprepitant/Fosaprepitant Injection The metabolism of Fosaprepitant can be increased when combined with Crizotinib.
Copanlisib Injection	Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Crizotinib.
Delafloxacin	Delafloxacin The risk or severity of QTc prolongation can be increased when Delafloxacin is combined with Crizotinib.
Abemaciclib	Abemaciclib The metabolism of Abemaciclib can be decreased when combined with Crizotinib.
Betrixaban	Betrixaban The serum concentration of Betrixaban can be increased when it is combined with Crizotinib.
Acalabrutinib	Acalabrutinib The metabolism of Crizotinib can be decreased when combined with Acalabrutinib.
Letermovir	Letermovir The metabolism of Crizotinib can be decreased when combined with Letermovir.
Tetrabenazine	Tetrabenazine The risk or severity of QTc prolongation can be increased when Crizotinib is combined with Tetrabenazine.
Ertugliflozin	Ertugliflozin The serum concentration of Ertugliflozin can be increased when it is combined with Crizotinib.
Buprenorphine Injection	Buprenorphine Injection The metabolism of Buprenorphine can be decreased when combined with Crizotinib.
Apalutamide	Apalutamide The serum concentration of Crizotinib can be decreased when it is combined with Apalutamide.
Fostamatinib	Fostamatinib The metabolism of Crizotinib can be decreased when combined with Fostamatinib.
Avatrombopag	Avatrombopag The serum concentration of Avatrombopag can be increased when it is combined with Crizotinib.
Baricitinib	Baricitinib The metabolism of Baricitinib can be decreased when combined with Crizotinib.
Lofexidine	Lofexidine The risk or severity of QTc prolongation can be increased when Lofexidine is combined with Crizotinib.
Eliglustat	Eliglustat The metabolism of Eliglustat can be decreased when combined with Crizotinib.
Encorafenib	Encorafenib The risk or severity of QTc prolongation can be increased when Crizotinib is combined with Encorafenib.
Binimetinib	Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Crizotinib.
Ivosidenib	Ivosidenib The metabolism of Ivosidenib can be decreased when combined with Crizotinib.
Lusutrombopag	Lusutrombopag The serum concentration of Lusutrombopag can be increased when it is combined with Crizotinib.
Elagolix	Elagolix The serum concentration of Elagolix can be increased when it is combined with Crizotinib.
Doravirine	Doravirine The metabolism of Doravirine can be decreased when combined with Crizotinib.
Cannabidiol	Cannabidiol The metabolism of Cannabidiol can be decreased when combined with Crizotinib.
Dacomitinib	Dacomitinib The metabolism of Dacomitinib can be decreased when combined with Crizotinib.
Duvelisib	Duvelisib The metabolism of Duvelisib can be decreased when combined with Crizotinib.
Omadacycline	Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Crizotinib.
Sarecycline	Sarecycline The serum concentration of Crizotinib can be increased when it is combined with Sarecycline.
Stiripentol	Stiripentol The metabolism of Crizotinib can be decreased when combined with Stiripentol.
Talazoparib	Talazoparib The serum concentration of Talazoparib can be increased when it is combined with Crizotinib.
Gilteritinib	Gilteritinib The metabolism of Gilteritinib can be decreased when combined with Crizotinib.
Glasdegib	Glasdegib The serum concentration of Glasdegib can be increased when it is combined with Crizotinib.
Lorlatinib	Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Crizotinib.
Larotrectinib	Larotrectinib The serum concentration of Larotrectinib can be increased when it is combined with Crizotinib.
Methoxy Polyethylene Glycol-Epoetin Beta Injection	Methoxy Polyethylene Glycol-Epoetin Beta Injection The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Crizotinib.
Paclitaxel (with albumin) Injection	Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Crizotinib.
Rifamycin	Rifamycin The serum concentration of Rifamycin can be increased when it is combined with Crizotinib.
Prucalopride	Prucalopride The serum concentration of Prucalopride can be increased when it is combined with Crizotinib.
Emapalumab-lzsg Injection	Emapalumab-lzsg Injection The metabolism of Crizotinib can be increased when combined with Emapalumab.
Siponimod	Siponimod The risk or severity of adverse effects can be increased when Crizotinib is combined with Siponimod.
Erdafitinib	Erdafitinib The metabolism of Crizotinib can be decreased when combined with Erdafitinib.
Alpelisib	Alpelisib The metabolism of Alpelisib can be decreased when combined with Crizotinib.
Solriamfetol	Solriamfetol The serum concentration of Solriamfetol can be increased when it is combined with Crizotinib.
Darolutamide	Darolutamide The serum concentration of Darolutamide can be increased when it is combined with Crizotinib.
Triclabendazole	Triclabendazole The metabolism of Crizotinib can be decreased when combined with Triclabendazole.
Entrectinib	Entrectinib The metabolism of Entrectinib can be decreased when combined with Crizotinib.
Pexidartinib	Pexidartinib The metabolism of Pexidartinib can be decreased when combined with Crizotinib.
Istradefylline	Istradefylline The serum concentration of Istradefylline can be increased when it is combined with Crizotinib.
Pitolisant	Pitolisant The serum concentration of Crizotinib can be decreased when it is combined with Pitolisant.
Pretomanid	Pretomanid The serum concentration of Pretomanid can be increased when it is combined with Crizotinib.
Fedratinib	Fedratinib The serum concentration of Fedratinib can be increased when it is combined with Crizotinib.
Lefamulin	Lefamulin Crizotinib may increase the QTc-prolonging activities of Lefamulin.
Phenytoin Injection	Phenytoin Injection The metabolism of Phenytoin can be increased when combined with Crizotinib.
Fosphenytoin Injection	Fosphenytoin Injection The metabolism of Crizotinib can be decreased when combined with Fosphenytoin.
Enfortumab vedotin-ejfv Injection	Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be increased when it is combined with Crizotinib.
Zanubrutinib	Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Crizotinib.
Voxelotor	Voxelotor The serum concentration of Voxelotor can be increased when it is combined with Crizotinib.
Lumateperone	Lumateperone The serum concentration of Lumateperone can be increased when it is combined with Crizotinib.
Lasmiditan	Lasmiditan The serum concentration of Crizotinib can be increased when it is combined with Lasmiditan.
Ubrogepant	Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Crizotinib.
Tazemetostat	Tazemetostat The metabolism of Tazemetostat can be decreased when combined with Crizotinib.
Cenobamate	Cenobamate The serum concentration of Crizotinib can be decreased when it is combined with Cenobamate.
Pemigatinib	Pemigatinib The metabolism of Pemigatinib can be decreased when combined with Crizotinib.
Selumetinib	Selumetinib The serum concentration of Selumetinib can be increased when it is combined with Crizotinib.
Rimegepant	Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Crizotinib.
Tucatinib	Tucatinib Crizotinib may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Remdesivir Injection	Remdesivir Injection The serum concentration of Remdesivir can be increased when it is combined with Crizotinib.
Ripretinib	Ripretinib The serum concentration of Ripretinib can be increased when it is combined with Crizotinib.
Selpercatinib	Selpercatinib The serum concentration of Selpercatinib can be increased when it is combined with Crizotinib.
Capmatinib	Capmatinib The serum concentration of Crizotinib can be increased when it is combined with Capmatinib.
Lemborexant	Lemborexant The serum concentration of Lemborexant can be increased when it is combined with Crizotinib.
Fostemsavir	Fostemsavir The risk or severity of QTc prolongation can be increased when Fostemsavir is combined with Crizotinib.
Lurbinectedin Injection	Lurbinectedin Injection The serum concentration of Lurbinectedin can be increased when it is combined with Crizotinib.
Octreotide	Octreotide The serum concentration of the active metabolites of Crizotinib can be increased when Crizotinib is used in combination with Octreotide.
Belantamab Mafodotin-blmf Injection	Belantamab Mafodotin-blmf Injection The serum concentration of Belantamab mafodotin can be increased when it is combined with Crizotinib.
Pralsetinib	Pralsetinib The serum concentration of Pralsetinib can be increased when it is combined with Crizotinib.
Satralizumab-mwge Injection	Satralizumab-mwge Injection The serum concentration of Crizotinib can be decreased when it is combined with Satralizumab.
Relugolix	Relugolix The serum concentration of Relugolix can be increased when it is combined with Crizotinib.
Progestin-Only (drospirenone) Oral Contraceptives	Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Crizotinib can be decreased when combined with Drospirenone.
Vitamin E (Alpha-Tocopherol)	Vitamin E (Alpha-Tocopherol) The metabolism of Crizotinib can be increased when combined with Vitamin E.
Theophylline	Theophylline The metabolism of Theophylline can be decreased when combined with Crizotinib.
Trazodone	Trazodone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Crizotinib.
Phenobarbital	Phenobarbital The metabolism of Crizotinib can be increased when combined with Phenobarbital.
Methotrexate Injection	Methotrexate Injection The metabolism of Methotrexate can be decreased when combined with Crizotinib.
Primidone	Primidone The metabolism of Crizotinib can be increased when combined with Primidone.
Methsuximide	Methsuximide The risk or severity of QTc prolongation can be increased when Methsuximide is combined with Crizotinib.
Chlorpromazine	Chlorpromazine The metabolism of Chlorpromazine can be increased when combined with Crizotinib.
Diazepam	Diazepam The metabolism of Diazepam can be decreased when combined with Crizotinib.
Lorazepam	Lorazepam The metabolism of Lorazepam can be decreased when combined with Crizotinib.
Amantadine	Amantadine The risk or severity of QTc prolongation can be increased when Amantadine is combined with Crizotinib.
Bromocriptine	Bromocriptine The metabolism of Crizotinib can be decreased when combined with Bromocriptine.
Tranylcypromine	Tranylcypromine The metabolism of Crizotinib can be decreased when combined with Tranylcypromine.
Phenelzine	Phenelzine The metabolism of Crizotinib can be decreased when combined with Phenelzine.
Tetracycline	Tetracycline The metabolism of Crizotinib can be decreased when combined with Tetracycline.
Prochlorperazine	Prochlorperazine The metabolism of Crizotinib can be decreased when combined with Prochlorperazine.
Thioridazine	Thioridazine The risk or severity of QTc prolongation can be increased when Crizotinib is combined with Thioridazine.
Dapsone	Dapsone The metabolism of Dapsone can be decreased when combined with Crizotinib.
Oxycodone	Oxycodone The metabolism of Oxycodone can be decreased when combined with Crizotinib.
Methadone	Methadone The metabolism of Methadone can be increased when combined with Crizotinib.
Oxybutynin	Oxybutynin The metabolism of Oxybutynin can be decreased when combined with Crizotinib.
Benztropine	Benztropine The risk or severity of QTc prolongation can be increased when Benzatropine is combined with Crizotinib.
Maprotiline	Maprotiline The risk or severity of QTc prolongation can be increased when Maprotiline is combined with Crizotinib.
Orphenadrine	Orphenadrine The metabolism of Crizotinib can be decreased when combined with Orphenadrine.
Phentermine	Phentermine The metabolism of Phentermine can be decreased when combined with Crizotinib.
Amoxapine	Amoxapine The risk or severity of QTc prolongation can be increased when Amoxapine is combined with Crizotinib.
Hydrocortisone	Hydrocortisone The metabolism of Hydrocortisone can be increased when combined with Crizotinib.
Doxorubicin	Doxorubicin The metabolism of Doxorubicin can be decreased when combined with Crizotinib.
Dactinomycin	Dactinomycin The serum concentration of Crizotinib can be increased when it is combined with Dactinomycin.
Carbamazepine	Carbamazepine The metabolism of Carbamazepine can be decreased when combined with Crizotinib.
Methyldopa	Methyldopa Methyldopa may increase the bradycardic activities of Crizotinib.
Clonidine	Clonidine The metabolism of Clonidine can be decreased when combined with Crizotinib.
Prazosin	Prazosin The serum concentration of Prazosin can be increased when it is combined with Crizotinib.
Hydralazine	Hydralazine The metabolism of Crizotinib can be decreased when combined with Hydralazine.
Cimetidine	Cimetidine The metabolism of Cimetidine can be decreased when combined with Crizotinib.
Warfarin	Warfarin The metabolism of Warfarin can be decreased when combined with Crizotinib.
Loperamide	Loperamide The metabolism of Crizotinib can be decreased when combined with Loperamide.
Promethazine	Promethazine The risk or severity of QTc prolongation can be increased when Promethazine is combined with Crizotinib.
Daunorubicin	Daunorubicin The metabolism of Crizotinib can be decreased when combined with Daunorubicin.
Griseofulvin	Griseofulvin The metabolism of Crizotinib can be increased when combined with Griseofulvin.
Digoxin	Digoxin Crizotinib may decrease the excretion rate of Digoxin which could result in a higher serum level.
Loxapine	Loxapine The serum concentration of Crizotinib can be increased when it is combined with Loxapine.
Chloroquine	Chloroquine The metabolism of Chloroquine can be decreased when combined with Crizotinib.
Quinine	Quinine The serum concentration of Quinine can be increased when it is combined with Crizotinib.
Ethosuximide	Ethosuximide The risk or severity of QTc prolongation can be increased when Ethosuximide is combined with Crizotinib.
Calcitriol	Calcitriol The metabolism of Crizotinib can be increased when combined with Calcitriol.
Sulfinpyrazone	Sulfinpyrazone The metabolism of Crizotinib can be increased when combined with Sulfinpyrazone.
Clindamycin Injection	Clindamycin Injection The metabolism of Clindamycin can be decreased when combined with Crizotinib.
Secobarbital	Secobarbital The metabolism of Crizotinib can be increased when combined with Secobarbital.
Desipramine	Desipramine The metabolism of Crizotinib can be decreased when combined with Desipramine.
Amitriptyline	Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Crizotinib.
Imipramine	Imipramine The serum concentration of Imipramine can be increased when it is combined with Crizotinib.
Probenecid	Probenecid The metabolism of Crizotinib can be increased when combined with Probenecid.
Quinidine	Quinidine The metabolism of Quinidine can be decreased when combined with Crizotinib.
Procainamide	Procainamide The risk or severity of QTc prolongation can be increased when Crizotinib is combined with Procainamide.
Isoniazid	Isoniazid The metabolism of Crizotinib can be decreased when combined with Isoniazid.
Rifampin	Rifampin The metabolism of Crizotinib can be increased when combined with Rifampicin.
Disopyramide	Disopyramide The risk or severity of QTc prolongation can be increased when Crizotinib is combined with Disopyramide.
Valproic Acid	Valproic Acid The metabolism of Valproic acid can be decreased when combined with Crizotinib.
Tamoxifen	Tamoxifen The metabolism of Crizotinib can be decreased when combined with Tamoxifen.
Levothyroxine	Levothyroxine The therapeutic efficacy of Crizotinib can be decreased when used in combination with Levothyroxine.
Liothyronine	Liothyronine The therapeutic efficacy of Liothyronine can be decreased when used in combination with Crizotinib.
Methimazole	Methimazole The therapeutic efficacy of Methimazole can be decreased when used in combination with Crizotinib.
Propylthiouracil	Propylthiouracil The therapeutic efficacy of Propylthiouracil can be decreased when used in combination with Crizotinib.
Dextromethorphan	Dextromethorphan The metabolism of Dextromethorphan can be decreased when combined with Crizotinib.
Niacin	Niacin The metabolism of Crizotinib can be decreased when combined with Niacin.
Doxylamine	Doxylamine The risk or severity of QTc prolongation can be increased when Doxylamine is combined with Crizotinib.
Cyproheptadine	Cyproheptadine The risk or severity of QTc prolongation can be increased when Cyproheptadine is combined with Crizotinib.
Clemastine	Clemastine The risk or severity of QTc prolongation can be increased when Crizotinib is combined with Clemastine.
Chlorpheniramine	Chlorpheniramine The metabolism of Crizotinib can be decreased when combined with Chlorpheniramine.
Brompheniramine	Brompheniramine The risk or severity of QTc prolongation can be increased when Dexbrompheniramine is combined with Crizotinib.
Hydrochlorothiazide	Hydrochlorothiazide The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Crizotinib.
Danazol	Danazol The metabolism of Crizotinib can be decreased when combined with Danazol.
Disulfiram	Disulfiram The metabolism of Crizotinib can be decreased when combined with Disulfiram.
Propranolol (Cardiovascular)	Propranolol (Cardiovascular) The metabolism of Propranolol can be decreased when combined with Crizotinib.
Nortriptyline	Nortriptyline The metabolism of Nortriptyline can be decreased when combined with Crizotinib.
Amphotericin B Injection	Amphotericin B Injection The metabolism of Crizotinib can be decreased when combined with Amphotericin B.
Nadolol	Nadolol Nadolol may increase the bradycardic activities of Crizotinib.
Oxytocin Injection	Oxytocin Injection The risk or severity of QTc prolongation can be increased when Oxytocin is combined with Crizotinib.
Clomiphene	Clomiphene The serum concentration of Clomifene can be increased when it is combined with Crizotinib.
Papaverine	Papaverine The risk or severity of QTc prolongation can be increased when Papaverine is combined with Crizotinib.
Fluorouracil Injection	Fluorouracil Injection The risk or severity of QTc prolongation can be increased when Fluorouracil is combined with Crizotinib.
Colchicine	Colchicine The metabolism of Colchicine can be decreased when combined with Crizotinib.
Cephalexin	Cephalexin The metabolism of Cephalexin can be decreased when combined with Crizotinib.
Acetazolamide	Acetazolamide The metabolism of Crizotinib can be decreased when combined with Acetazolamide.
Calcitonin Salmon Injection	Calcitonin Salmon Injection The therapeutic efficacy of Salmon calcitonin can be decreased when used in combination with Crizotinib.
Ketoconazole	Ketoconazole The serum concentration of Crizotinib can be increased when it is combined with Ketoconazole.
Thiotepa Injection	Thiotepa Injection The metabolism of Thiotepa can be decreased when combined with Crizotinib.
Vincristine Injection	Vincristine Injection The metabolism of Vincristine can be decreased when combined with Crizotinib.
Vinblastine	Vinblastine The metabolism of Crizotinib can be decreased when combined with Vinblastine.
Metoprolol	Metoprolol The metabolism of Metoprolol can be decreased when combined with Crizotinib.
Hydroxyzine	Hydroxyzine The risk or severity of QTc prolongation can be increased when Hydroxyzine is combined with Crizotinib.
Thiothixene	Thiothixene The risk or severity of QTc prolongation can be increased when Thiothixene is combined with Crizotinib.
Alprazolam	Alprazolam The metabolism of Alprazolam can be decreased when combined with Crizotinib.
Triazolam	Triazolam The metabolism of Triazolam can be decreased when combined with Crizotinib.
Hyoscyamine	Hyoscyamine The risk or severity of QTc prolongation can be increased when Hyoscyamine is combined with Crizotinib.
Diltiazem	Diltiazem The metabolism of Crizotinib can be decreased when combined with Diltiazem.
Nifedipine	Nifedipine The metabolism of Nifedipine can be increased when combined with Crizotinib.
Timolol	Timolol The risk or severity of QTc prolongation can be increased when Timolol is combined with Crizotinib.
Verapamil	Verapamil The serum concentration of Crizotinib can be increased when it is combined with Verapamil.
Atenolol	Atenolol Atenolol may increase the bradycardic activities of Crizotinib.
Pindolol	Pindolol Pindolol may increase the bradycardic activities of Crizotinib.
Cisplatin Injection	Cisplatin Injection The serum concentration of Cisplatin can be increased when it is combined with Crizotinib.
Etoposide	Etoposide The metabolism of Crizotinib can be decreased when combined with Etoposide.
Glyburide	Glyburide The metabolism of Glyburide can be decreased when combined with Crizotinib.
Indapamide	Indapamide The risk or severity of QTc prolongation can be increased when Indapamide is combined with Crizotinib.
Dicloxacillin	Dicloxacillin The metabolism of Crizotinib can be increased when combined with Dicloxacillin.
Nafcillin Injection	Nafcillin Injection The metabolism of Crizotinib can be increased when combined with Nafcillin.
Pentamidine Injection	Pentamidine Injection The metabolism of Crizotinib can be decreased when combined with Pentamidine.
Labetalol	Labetalol Labetalol may increase the bradycardic activities of Crizotinib.
Leuprolide Injection	Leuprolide Injection The risk or severity of QTc prolongation can be increased when Leuprolide is combined with Crizotinib.
Pimozide	Pimozide The metabolism of Pimozide can be decreased when combined with Crizotinib.
Amiodarone	Amiodarone The metabolism of Amiodarone can be decreased when combined with Crizotinib.
Buspirone	Buspirone The metabolism of Buspirone can be decreased when combined with Crizotinib.
Lovastatin	Lovastatin The metabolism of Lovastatin can be decreased when combined with Crizotinib.
Ciprofloxacin	Ciprofloxacin The metabolism of Crizotinib can be decreased when combined with Ciprofloxacin.
Fluoxetine	Fluoxetine The risk or severity of QTc prolongation can be increased when Crizotinib is combined with Fluoxetine.
Nimodipine	Nimodipine The risk or severity of QTc prolongation can be increased when Nimodipine is combined with Crizotinib.
Clozapine	Clozapine The metabolism of Crizotinib can be increased when combined with Clozapine.
Ofloxacin	Ofloxacin The risk or severity of QTc prolongation can be increased when Ofloxacin is combined with Crizotinib.
Clarithromycin	Clarithromycin The serum concentration of Crizotinib can be increased when it is combined with Clarithromycin.
Felodipine	Felodipine The metabolism of Felodipine can be decreased when combined with Crizotinib.
Pravastatin	Pravastatin The serum concentration of Pravastatin can be increased when it is combined with Crizotinib.
Simvastatin	Simvastatin The serum concentration of Simvastatin can be increased when it is combined with Crizotinib.
Epoetin Alfa, Injection	Epoetin Alfa, Injection The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Crizotinib.
Amlodipine	Amlodipine Amlodipine may increase the bradycardic activities of Crizotinib.
Teniposide Injection	Teniposide Injection The metabolism of Teniposide can be decreased when combined with Crizotinib.
Itraconazole	Itraconazole The serum concentration of Crizotinib can be increased when it is combined with Itraconazole.
Rifabutin	Rifabutin The metabolism of Crizotinib can be increased when combined with Rifabutin.
Sotalol	Sotalol The risk or severity of QTc prolongation can be increased when Crizotinib is combined with Sotalol.
Bisoprolol	Bisoprolol The serum concentration of Crizotinib can be increased when it is combined with Bisoprolol.
Doxazosin	Doxazosin The metabolism of Doxazosin can be decreased when combined with Crizotinib.
Isradipine	Isradipine The metabolism of Crizotinib can be decreased when combined with Isradipine.
Omeprazole	Omeprazole The metabolism of Crizotinib can be increased when combined with Omeprazole.
Cisapride	Cisapride The metabolism of Crizotinib can be decreased when combined with Cisapride.
Fluvastatin	Fluvastatin The metabolism of Fluvastatin can be decreased when combined with Crizotinib.
Venlafaxine	Venlafaxine The risk or severity of QTc prolongation can be increased when Venlafaxine is combined with Crizotinib.
Famciclovir	Famciclovir The metabolism of Famciclovir can be decreased when combined with Crizotinib.
Fluvoxamine	Fluvoxamine The metabolism of Crizotinib can be decreased when combined with Fluvoxamine.
Nefazodone	Nefazodone The metabolism of Crizotinib can be decreased when combined with Nefazodone.
Lamotrigine	Lamotrigine The risk or severity of QTc prolongation can be increased when Lamotrigine is combined with Crizotinib.
Losartan	Losartan The metabolism of Crizotinib can be decreased when combined with Losartan.
Tramadol	Tramadol The metabolism of Tramadol can be decreased when combined with Crizotinib.
Vinorelbine Injection	Vinorelbine Injection The metabolism of Vinorelbine can be decreased when combined with Crizotinib.
Moexipril	Moexipril The risk or severity of QTc prolongation can be increased when Moexipril is combined with Crizotinib.
Lansoprazole	Lansoprazole The metabolism of Crizotinib can be increased when combined with Lansoprazole.
Ifosfamide Injection	Ifosfamide Injection The metabolism of Ifosfamide can be decreased when combined with Crizotinib.
Nicardipine	Nicardipine The metabolism of Crizotinib can be decreased when combined with Nicardipine.
Ticlopidine	Ticlopidine The metabolism of Ticlopidine can be decreased when combined with Crizotinib.
Saquinavir	Saquinavir The serum concentration of Crizotinib can be increased when it is combined with Saquinavir.
Metformin	Metformin The serum concentration of Metformin can be increased when it is combined with Crizotinib.
Nisoldipine	Nisoldipine The metabolism of Nisoldipine can be decreased when combined with Crizotinib.
Lamivudine	Lamivudine The serum concentration of Lamivudine can be increased when it is combined with Crizotinib.
Gemcitabine Injection	Gemcitabine Injection The serum concentration of Gemcitabine can be increased when it is combined with Crizotinib.
Indinavir	Indinavir The metabolism of Indinavir can be decreased when combined with Crizotinib.
Ritonavir	Ritonavir The serum concentration of Crizotinib can be increased when it is combined with Ritonavir.
Docetaxel Injection	Docetaxel Injection The metabolism of Docetaxel can be decreased when combined with Crizotinib.
Clomipramine	Clomipramine The metabolism of Crizotinib can be decreased when combined with Clomipramine.
Zafirlukast	Zafirlukast The metabolism of Crizotinib can be decreased when combined with Zafirlukast.
Mirtazapine	Mirtazapine The metabolism of Crizotinib can be decreased when combined with Mirtazapine.
Topiramate	Topiramate The metabolism of Crizotinib can be increased when combined with Topiramate.
Pramipexole	Pramipexole The serum concentration of Pramipexole can be increased when it is combined with Crizotinib.
Donepezil	Donepezil Donepezil may increase the bradycardic activities of Crizotinib.
Nelfinavir	Nelfinavir The metabolism of Crizotinib can be decreased when combined with Nelfinavir.
Fexofenadine	Fexofenadine The serum concentration of Crizotinib can be increased when it is combined with Fexofenadine.
Azithromycin	Azithromycin The metabolism of Azithromycin can be decreased when combined with Crizotinib.
Carvedilol	Carvedilol The serum concentration of Crizotinib can be increased when it is combined with Carvedilol.
Flutamide	Flutamide The metabolism of Flutamide can be decreased when combined with Crizotinib.
Bicalutamide	Bicalutamide The metabolism of Crizotinib can be decreased when combined with Bicalutamide.
Propafenone	Propafenone The serum concentration of Crizotinib can be increased when it is combined with Propafenone.
Raloxifene	Raloxifene The metabolism of Crizotinib can be decreased when combined with Raloxifene.
Irbesartan	Irbesartan The metabolism of Crizotinib can be decreased when combined with Irbesartan.
Finasteride	Finasteride The metabolism of Finasteride can be decreased when combined with Crizotinib.
Quetiapine	Quetiapine The metabolism of Quetiapine can be decreased when combined with Crizotinib.
Cetirizine	Cetirizine The risk or severity of QTc prolongation can be increased when Cetirizine is combined with Crizotinib.
Paroxetine	Paroxetine The metabolism of Crizotinib can be decreased when combined with Paroxetine.
Citalopram	Citalopram The metabolism of Citalopram can be decreased when combined with Crizotinib.
Efavirenz	Efavirenz The metabolism of Crizotinib can be increased when combined with Efavirenz.
Sildenafil	Sildenafil The serum concentration of Sildenafil can be increased when it is combined with Crizotinib.
Tolterodine	Tolterodine The risk or severity of QTc prolongation can be increased when Tolterodine is combined with Crizotinib.
Thalidomide	Thalidomide The metabolism of Crizotinib can be increased when combined with Thalidomide.
Nateglinide	Nateglinide The metabolism of Nateglinide can be decreased when combined with Crizotinib.
Galantamine	Galantamine The risk or severity of QTc prolongation can be increased when Galantamine is combined with Crizotinib.
Rabeprazole	Rabeprazole The metabolism of Crizotinib can be decreased when combined with Rabeprazole.
Terbinafine	Terbinafine The metabolism of Crizotinib can be increased when combined with Terbinafine.