Methyldopa

Generic name: Pronounced as (meth ill doe' pa)
Brand names
  • Aldomet®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 05/15/2017

Methyldopa is used to treat high blood pressure. Methyldopa is in a class of medications called antihypertensives. It works by relaxing the blood vessels so that blood can flow more easily through the body.

High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.

Methyldopa comes as a tablet and a liquid to take by mouth. It usually is taken two to four times a day. To help you remember to take methyldopa, take it around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take methyldopa exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Shake the liquid well before each dose to mix the medication evenly. Use a dose-measuring spoon or cup to measure the correct amount of liquid for each dose, not a regular household spoon.

Methyldopa controls high blood pressure but does not cure it. Continue to take methyldopa even if you feel well. Do not stop taking methyldopa without talking to your doctor. If you suddenly stop taking methyldopa, your blood pressure may increase and you may experience side effects. Your doctor will decrease your dose gradually.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Before taking methyldopa,

  • tell your doctor and pharmacist if you are allergic to methyldopa, any other medications, sulfites, or any of the ingredients in methyldopa tablets or liquid. Ask your doctor or pharmacist for a list of the ingredients.

  • tell your doctor if you are taking a monoamine oxidase (MAOs) inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate). Your doctor will probably tell you not to take methyldopa.

  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: haloperidol (Haldol), levodopa (in Sinemet, in Stalevo), lithium (Lithobid), other medications for high blood pressure, and tolbutamide. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • do not take with iron supplements or vitamins containing iron.

  • tell you doctor if you have or have ever had kidney or liver disease, including hepatitis or cirrhosis.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking methyldopa, call your doctor.

  • talk to your doctor about the risks of taking methyldopa if you are 65 years of age or older. Older adults should not usually take methyldopa because it is not as safe as other medications that can be used to treat the same condition.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking methyldopa.

  • you should know that this medication may make you drowsy. Do not drive a car or operate machinery for 48-72 hours after you begin to take methyldopa or after your dose is increased.

Your doctor may prescribe a low-salt or low-sodium diet. Follow these directions carefully.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Methyldopa may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • headache

    • muscle weakness

    • swollen ankles or feet

    • upset stomach

    • vomiting

    • diarrhea

    • gas

    • dry mouth

    • rash

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

    • unexplained fever

    • extreme tiredness

    • yellowing of the skin or eyes

  • Methyldopa may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store tablets at room temperature and away from excess heat and moisture (not in the bathroom). The liquid may be stored in the refrigerator or at room temperature.

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor and the laboratory. Your blood pressure should be checked regularly to determine your response to methyldopa. Your doctor may order certain lab tests to monitor your red blood cell count and liver function.

Methyldopa may cause your urine to darken when it is exposed to air. This effect is harmless.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

  • Aldochlor® (containing Chlorothiazide, Methyldopa)

Drug Interaction
Naratriptan Naratriptan Naratriptan may decrease the antihypertensive activities of Methyldopa.
Penbutolol Penbutolol The therapeutic efficacy of Methyldopa can be decreased when used in combination with Acebutolol.
Triamcinolone Triamcinolone The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Triamcinolone is combined with Methyldopa.
Zolmitriptan Zolmitriptan Zolmitriptan may decrease the antihypertensive activities of Methyldopa.
Pamidronate Injection Pamidronate Injection Pamidronic acid may decrease the excretion rate of Methyldopa which could result in a higher serum level.
Vancomycin Injection Vancomycin Injection Methyldopa may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Zidovudine Injection Zidovudine Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Zidovudine is combined with Methyldopa.
Trimipramine Trimipramine The therapeutic efficacy of Methyldopa can be decreased when used in combination with Trimipramine.
Tenofovir Tenofovir Tenofovir may decrease the excretion rate of Methyldopa which could result in a higher serum level.
Apomorphine Injection Apomorphine Injection The risk or severity of adverse effects can be increased when Apomorphine is combined with Methyldopa.
Tinidazole Tinidazole Tinidazole may decrease the excretion rate of Methyldopa which could result in a higher serum level.
Ibandronate Ibandronate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Ibandronate is combined with Methyldopa.
Rasagiline Rasagiline Rasagiline may decrease the hypotensive activities of Methyldopa.
Rituximab Injection Rituximab Injection Methyldopa may increase the hypotensive activities of Rituximab.
Azacitidine Injection Azacitidine Injection Azacitidine may decrease the excretion rate of Methyldopa which could result in a higher serum level.
Doripenem Injection Doripenem Injection Methyldopa may decrease the excretion rate of Doripenem which could result in a higher serum level.
Tretinoin Tretinoin The risk or severity of adverse effects can be increased when Tretinoin is combined with Methyldopa.
Betaxolol Betaxolol The therapeutic efficacy of Methyldopa can be decreased when used in combination with Betaxolol.
Fingolimod Fingolimod Methyldopa may increase the bradycardic activities of Fingolimod.
Ceftaroline Injection Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Methyldopa which could result in a higher serum level.
Lurasidone Lurasidone Lurasidone may decrease the antihypertensive activities of Methyldopa.
Vilazodone Vilazodone Vilazodone may decrease the antihypertensive activities of Methyldopa.
Ipilimumab Injection Ipilimumab Injection Methyldopa may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Terbutaline Injection Terbutaline Injection Terbutaline may decrease the excretion rate of Methyldopa which could result in a higher serum level.
Azilsartan Azilsartan The risk or severity of adverse effects can be increased when Azilsartan medoxomil is combined with Methyldopa.
Roflumilast Roflumilast Methyldopa may decrease the excretion rate of Roflumilast which could result in a higher serum level.
Rivaroxaban Rivaroxaban Methyldopa may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Ruxolitinib Ruxolitinib Ruxolitinib may increase the bradycardic activities of Methyldopa.
Deferiprone Deferiprone Methyldopa may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Crizotinib Crizotinib Methyldopa may increase the bradycardic activities of Crizotinib.
Enzalutamide Enzalutamide Methyldopa may decrease the excretion rate of Enzalutamide which could result in a higher serum level.
Mirabegron Mirabegron Methyldopa may decrease the excretion rate of Mirabegron which could result in a higher serum level.
Regorafenib Regorafenib Methyldopa may increase the bradycardic activities of Regorafenib.
Teduglutide Injection Teduglutide Injection Methyldopa may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Tofacitinib Tofacitinib Methyldopa may increase the bradycardic activities of Tofacitinib.
Alogliptin Alogliptin Methyldopa may decrease the excretion rate of Alogliptin which could result in a higher serum level.
Pomalidomide Pomalidomide Methyldopa may decrease the excretion rate of Pomalidomide which could result in a higher serum level.
Canagliflozin Canagliflozin Methyldopa may increase the excretion rate of Canagliflozin which could result in a lower serum level and potentially a reduction in efficacy.
Trametinib Trametinib Methyldopa may decrease the excretion rate of Trametinib which could result in a higher serum level.
Levomilnacipran Levomilnacipran Methyldopa may increase the tachycardic activities of Levomilnacipran.
Vortioxetine Vortioxetine Methyldopa may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Avanafil Avanafil Avanafil may increase the antihypertensive activities of Methyldopa.
Sofosbuvir Sofosbuvir Methyldopa may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin Dapagliflozin Dapagliflozin may increase the excretion rate of Methyldopa which could result in a lower serum level and potentially a reduction in efficacy.
Apremilast Apremilast Methyldopa may decrease the excretion rate of Apremilast which could result in a higher serum level.
Droxidopa Droxidopa Methyldopa may decrease the excretion rate of Droxidopa which could result in a higher serum level.
Ceritinib Ceritinib Methyldopa may increase the bradycardic activities of Ceritinib.
Ferric Carboxymaltose Injection Ferric Carboxymaltose Injection Ferric carboxymaltose can cause a decrease in the absorption of Methyldopa resulting in a reduced serum concentration and potentially a decrease in efficacy.
Testosterone Injection Testosterone Injection Testosterone may decrease the excretion rate of Methyldopa which could result in a higher serum level.
Empagliflozin Empagliflozin The risk or severity of adverse effects can be increased when Empagliflozin is combined with Methyldopa.
Tasimelteon Tasimelteon Methyldopa may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Riociguat Riociguat Methyldopa may increase the hypotensive activities of Riociguat.
Macitentan Macitentan Methyldopa may decrease the excretion rate of Macitentan which could result in a higher serum level.
Ziprasidone Injection Ziprasidone Injection Ziprasidone may increase the antihypertensive activities of Methyldopa.
Lixisenatide Injection Lixisenatide Injection Methyldopa may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives Drospirenone may increase the excretion rate of Methyldopa which could result in a lower serum level and potentially a reduction in efficacy.
Viloxazine Viloxazine Methyldopa may decrease the excretion rate of Viloxazine which could result in a higher serum level.
Tobramycin Injection Tobramycin Injection Tobramycin may decrease the excretion rate of Methyldopa which could result in a higher serum level.
Tolmetin Tolmetin The therapeutic efficacy of Methyldopa can be decreased when used in combination with Tolmetin.
Sulindac Sulindac The therapeutic efficacy of Methyldopa can be decreased when used in combination with Sulindac.
Trazodone Trazodone The therapeutic efficacy of Methyldopa can be decreased when used in combination with Trazodone.
Sucralfate Sucralfate Sucralfate may decrease the excretion rate of Methyldopa which could result in a higher serum level.
Tranylcypromine Tranylcypromine Tranylcypromine may decrease the hypotensive activities of Methyldopa.
Tetracycline Tetracycline Tetracycline may decrease the excretion rate of Methyldopa which could result in a higher serum level.
Thioridazine Thioridazine The therapeutic efficacy of Methyldopa can be decreased when used in combination with Thioridazine.
Trifluoperazine Trifluoperazine The therapeutic efficacy of Methyldopa can be decreased when used in combination with Trifluoperazine.
Sulfadiazine Sulfadiazine Sulfadiazine may decrease the excretion rate of Methyldopa which could result in a higher serum level.
Benztropine Benztropine Benzatropine may decrease the excretion rate of Methyldopa which could result in a higher serum level.
Azathioprine Azathioprine Methyldopa may decrease the excretion rate of Azathioprine which could result in a higher serum level.
Warfarin Warfarin Methyldopa may decrease the excretion rate of Warfarin which could result in a higher serum level.
Triamterene Triamterene Triamterene may decrease the excretion rate of Methyldopa which could result in a higher serum level.
Liothyronine Liothyronine Liothyronine may decrease the excretion rate of Methyldopa which could result in a higher serum level.
Tolbutamide Tolbutamide Methyldopa may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Tolazamide Tolazamide Tolazamide may decrease the excretion rate of Methyldopa which could result in a higher serum level.
Baclofen Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Methyldopa.
Vincristine Injection Vincristine Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Vincristine is combined with Methyldopa.
Aspirin Aspirin Acetylsalicylic acid may decrease the excretion rate of Methyldopa which could result in a higher serum level.
Temazepam Temazepam Temazepam may decrease the excretion rate of Methyldopa which could result in a higher serum level.
Triazolam Triazolam The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Triazolam is combined with Methyldopa.
Trimethoprim Trimethoprim The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Trimethoprim is combined with Methyldopa.
Timolol Timolol The therapeutic efficacy of Methyldopa can be decreased when used in combination with Timolol.
Verapamil Verapamil The therapeutic efficacy of Methyldopa can be decreased when used in combination with Verapamil.
Atenolol Atenolol The therapeutic efficacy of Methyldopa can be decreased when used in combination with Atenolol.
Auranofin Auranofin Methyldopa may decrease the excretion rate of Auranofin which could result in a higher serum level.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Methyldopa which could result in a higher serum level.
Aztreonam Injection Aztreonam Injection Aztreonam may decrease the excretion rate of Methyldopa which could result in a higher serum level.
Tramadol Tramadol Tramadol may decrease the excretion rate of Methyldopa which could result in a higher serum level.
Ticlopidine Ticlopidine Ticlopidine may decrease the excretion rate of Methyldopa which could result in a higher serum level.
Gemcitabine Injection Gemcitabine Injection Gemcitabine may decrease the excretion rate of Methyldopa which could result in a higher serum level.
Indinavir Indinavir The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Indinavir is combined with Methyldopa.
Donepezil Donepezil Donepezil may increase the bradycardic activities of Methyldopa.
Sildenafil Sildenafil The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Methyldopa.
Celecoxib Celecoxib The therapeutic efficacy of Methyldopa can be decreased when used in combination with Celecoxib.
Tolterodine Tolterodine Methyldopa may decrease the excretion rate of Tolterodine which could result in a higher serum level.
Thalidomide Thalidomide The risk or severity of adverse effects can be increased when Thalidomide is combined with Methyldopa.
Rabeprazole Rabeprazole Methyldopa may decrease the excretion rate of Rabeprazole which could result in a higher serum level.

* This branded product is no longer on the market. Generic alternatives may be available.

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